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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
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            <taxon>Sordariomycetes</taxon>
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                <person name="Untereiner W.A."/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="747"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="759"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ83043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="829" mass="91739" checksum="B18BE9B426C1470C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN57</accession>
    <name>Q2GN57_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_10597</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228524.1">
        <property type="nucleotide sequence ID" value="XM_001228523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN57"/>
    <dbReference type="STRING" id="306901.Q2GN57"/>
    <dbReference type="GeneID" id="4396152"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10597"/>
    <dbReference type="eggNOG" id="ENOG502SMNP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045148_0_2_1"/>
    <dbReference type="InParanoid" id="Q2GN57"/>
    <dbReference type="OMA" id="HHYESEG"/>
    <dbReference type="OrthoDB" id="405906at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="3">
        <location>
            <begin position="20"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ84193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="395" mass="42826" checksum="76A212823F35F91B" modified="2006-03-21" version="1">MAPKDNGISRESVPTGTTLTIIVVFISVALYNVGELAFIIMATFKRRSGLYFWSFVVATGGIVPYAVGFLIKALQSPCPNWLYVTMIVVGWCCMVTGQSVVLYSRLHLVLRNERRLRMVLIMIITNAIICHIPITVMVYGANSSNPDPFVAPYSVYERVQVTLFFIQEAIISALYIHETVELMRTRSGGGMDGGARGSAARWLMTHLIAVNIIVVMLDVTILALEYAGLYDVQTSCKALAYSIKLKLEFSVLNRLVEITRGGTSGHDSSYDRTPVDRSGVRMGTLDGEQRRNWKSQAGGGGSGMGNRVHVRSCARPSVELAEPAGASVMMTTEVTVQRVRRGSISGVEGDGDGGSDLVSIGEASGMTLESTTEGTAGQSRAPSHSSERQIIERVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN88</accession>
    <name>Q2GN88_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228493.1">
        <property type="nucleotide sequence ID" value="XM_001228492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN88"/>
    <dbReference type="GeneID" id="4396445"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10566"/>
    <dbReference type="HOGENOM" id="CLU_792264_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GN88"/>
    <dbReference type="OrthoDB" id="4588914at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="350" mass="38667" checksum="E04C160DFF920666" modified="2006-03-21" version="1">MAHDNGPSTPSGSQVPDHITRSAPGSADATPKPRSLHPSASSSPSQQLPSRPTNESLPKSLLPAAELYESTPKLKSSESTLLQAFYEPLHSLDMAADFKPGSDGDSSARVGQTIPPEYWVPININHYLVIANAHLSKNSVKQALSARHTPTLEPTFRVRREADIVTYSSTHLTYAVSHALGATLAQPVEVTNEYQYSNLARVDRVWRSWGATTGSFAMLEIKNYGIIDAEEFQRAMYREPGVKNSTLFANLSILSIIKQITNYVQIPTYGTRYASLYDGKYLFLGVFETPPQPTDRPILKGTLVPCTGAENTQARRALLGWLIEAWEKKQRGENENIAETQRPPRPPRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNB6</accession>
    <name>Q2GNB6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_10538</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228465.1">
        <property type="nucleotide sequence ID" value="XM_001228464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNB6"/>
    <dbReference type="FunCoup" id="Q2GNB6">
        <property type="interactions" value="273"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GNB6"/>
    <dbReference type="GeneID" id="4396393"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10538"/>
    <dbReference type="eggNOG" id="KOG0998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002006_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNB6"/>
    <dbReference type="OMA" id="AMYLVRQ"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd14270">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF170">
        <property type="entry name" value="DYNAMIN ASSOCIATED PROTEIN 160, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="14">
        <location>
            <begin position="60"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="14">
        <location>
            <begin position="212"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="245"/>
            <end position="280"/>
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    <sequence length="1210" mass="126772" checksum="6DCC429E340678AE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNC0</accession>
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                <person name="Untereiner W.A."/>
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            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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</entry>
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            <taxon>Sordariomycetes</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
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        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
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    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="5">
        <location>
            <begin position="51"/>
            <end position="253"/>
        </location>
    </feature>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ84087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="313" mass="34577" checksum="41F66F0472C0A7B7" modified="2006-03-21" version="1">MHEADALLVWGPGCRPCVLAGDERQLTPTVMRHGESRQGRIVNVYSHQSKASVLEKLRRSGWQRFILTTQYRIVRGSFDLAQSIIYPDIKNLFEYGETTALEHHPITTKIETWVTTEYKVSASPAGTILPLFFHYHDSHCEVDKDMGSRYNKPQNALVVKLVRDLVNLGVTTSDIVVITPYRANLDRLEKTLKAAGCDVAVSTIDSRQGREGLVVVLALVVDRTTNPLFVVDPHRICVATTRHVGALFVVGDINSAGDARDRAEGRLFQHRLVLLFSSYLVTDIAGWQAESSSISPPGAMLGLAAQAASRRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNG6</accession>
    <name>Q2GNG6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10488</name>
    </gene>
    <organism evidence="3 4">
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
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            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
            <begin position="31"/>
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            <end position="306"/>
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        <location>
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            <end position="52"/>
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        <location>
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            <end position="233"/>
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            <end position="303"/>
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    </feature>
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        <location>
            <begin position="391"/>
            <end position="406"/>
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    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ84084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="439" mass="48901" checksum="C8F4ADAC0D377AAB" modified="2006-03-21" version="1">MAGSQQGNGFDLDPLEFMDFSQYDNTTTDTTSNALSFHPSSLSPSTSISLKSETPEGSSLFPTNQGFAAPSHQYNLYKQQTGLVPGALTTTLSMNEPQGYFQEYLDLQQQHDMLAGIGESDDVFDFNAPLPTGLDTSGMDLGFESSDAGLYLGSTINPSAIGGHEPDGLTSPLPTTPALSSTPGRVWPGMHQQQAAIARAQQQQKQQEMQRQQQQQQQLQRQRVQAKQAQKARSPQTSSSIAEQNVQNILSSMRSEPVQYTPIKSVPTANFPKKQKSEAEMDEDEKFLASEEGKKLSSQERRQLRNKVSARAFRGRRKEYIGWLEGELTDRHNDSGLLRAQNKALIEENARLTNLTKMLLSSDHFRDLLSDLSSNPEKLDDLHSAGEPHVQAHARQQAQQEAEMQARLQAEKDANPHLAEQQHLRYQEHFRLHMMSGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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            <taxon>Sordariomycetes</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
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        <text evidence="2">Belongs to the RRP12 family.</text>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_003753_1_0_1"/>
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    <dbReference type="Proteomes" id="UP000001056">
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    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="15"/>
            <end position="245"/>
        </location>
    </feature>
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        <location>
            <begin position="335"/>
            <end position="626"/>
        </location>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        </location>
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        <location>
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        <location>
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        <location>
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        <location>
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        <location>
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        <location>
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        <location>
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            <end position="1243"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF25772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ83918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1268" mass="137561" checksum="5F57BCD6EFE5F10E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPE2</accession>
    <name>Q2GPE2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTPase-activating protein GYP5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_10162</name>
    </gene>
    <organism evidence="13 14">
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GYP5 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001228088.1"/>
    </dbReference>
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    <dbReference type="STRING" id="306901.Q2GPE2"/>
    <dbReference type="GeneID" id="4396709"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10162"/>
    <dbReference type="eggNOG" id="KOG1102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008177_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPE2"/>
    <dbReference type="OMA" id="HDMPGLH"/>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
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    <dbReference type="Gene3D" id="1.10.472.80">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="12">
        <location>
            <begin position="385"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="419"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="754"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ83758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="889" mass="98078" checksum="36D60B5218303B43" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQ20</accession>
    <name>Q2GQ20_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_09934</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227861.1">
        <property type="nucleotide sequence ID" value="XM_001227860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQ20"/>
    <dbReference type="STRING" id="306901.Q2GQ20"/>
    <dbReference type="GeneID" id="4396853"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09934"/>
    <dbReference type="eggNOG" id="KOG1679">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_370878_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQ20"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF171">
        <property type="entry name" value="SD19268P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="5">
        <location>
            <begin position="15"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="113"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="460"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ83530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="750" mass="80800" checksum="94F5DFD247BFF5EC" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQ71</accession>
    <name>Q2GQ71_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_09883</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-lactamase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227810.1">
        <property type="nucleotide sequence ID" value="XM_001227809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQ71"/>
    <dbReference type="STRING" id="306901.Q2GQ71"/>
    <dbReference type="GeneID" id="4396883"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09883"/>
    <dbReference type="eggNOG" id="ENOG502T7EC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_563828_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQ71"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058664">
        <property type="entry name" value="ARB_00930-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF95">
        <property type="entry name" value="BETA-LACTAMASE-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935">
        <property type="entry name" value="PENICILLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26335">
        <property type="entry name" value="ARB_00930_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="50"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-like ARB-00930-like C-terminal" evidence="3">
        <location>
            <begin position="179"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ83479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="52666" checksum="CAA6D1DB2B5D097A" modified="2006-03-21" version="1">MKQYRWPWPPSRISLNQMTSTYNTTAVAIGVKSIHEPDLLFEYTYTPPNKDKKGVQKVDLDTIFRLGSLTKVFPVLALLKLKDQGVSLDDPITNSNFLGCSGFFGMPGCNKTVFFEHFGQRPPAQVPFSPQTVYSNIAFPILSFAVEAITNQSFTEYVTNEIWKPTNIPLLPAIEAAGKSETAAAYAGTYTDKRTNSTLTLSLTAAADDDDDDGPGIAITRYIMRGVDVPRTDPGSTLPPATAPVLDPPMRYRLYPASTGAEGETSWRAVGTRATAEQVREQDGLFAWGMNSPLSAAKPVKVLGSDILQGCAPVCLANDDSDQLGVRDDAEPHGVIHEIEQVMLADAALGPFYNAQLVLDPFDAMTIKLVAASLMFPFSPVKNQERTRAAFSLNLALVHHVQFDLCSVHPGPLQANEEEGVHKSHKSNLASPSLAIDQDIPWVDVTASVRHTPVTSFGIARCSLITLDALLIDRSTVYAEHSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQ75</accession>
    <name>Q2GQ75_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_09879</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227806.1">
        <property type="nucleotide sequence ID" value="XM_001227805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQ75"/>
    <dbReference type="FunCoup" id="Q2GQ75">
        <property type="interactions" value="1214"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GQ75"/>
    <dbReference type="GeneID" id="4396022"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09879"/>
    <dbReference type="eggNOG" id="KOG2573">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015495_4_0_1"/>
    <dbReference type="InParanoid" id="Q2GQ75"/>
    <dbReference type="OMA" id="PDNYMFA"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000001">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="7">
        <location>
            <begin position="302"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="446"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ83475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="511" mass="56237" checksum="2A2701531F05131F" modified="2006-03-21" version="1">MVVVNYLLFESAVGFSLFEVVHQADTVGLELPEVKDAMKSLDKFGKMIQLRSFNPWTSAAHGLEAINLISEGIMPDHLKNTLELNLPQTSGKKSKIVLGVVDKRLAGEISAAFPGVQCEAADTSEVVAALLRGIRLHANKLLKGLQEGDINRAQLGLGHAYSRAKVKFSVHKNDNHIIQGIATLDALDKGINQSAMRVREWYGWHFPELIRIVSDNGTYAKLVLAIGNKGTLSDESVDDLANVLNQDQDKAEAIIQAAKISMGQDISDTDLAMVKDLASNVSKMADFRRILAESLDKKMGDVAPNLQVILGTPVAARLISHAGSLTNLAKYPASTLQILGAEKALFRALKTKGATPKYGLLYQSSFIGRAGPKVKGRISRYLANKCSIASRIDNFSEKPTKRFGEVMRDQLEQRLEWYAKGTKPMKNIDAMGKAMQAIMDDGDDMDIDEEMIDHPPAKEKKDKKEKKEKKEKKEKKDKKRKSVGGEDVEMADVNGDGEKKKKKKRKSVAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQ80</accession>
    <name>Q2GQ80_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227801.1">
        <property type="nucleotide sequence ID" value="XM_001227800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQ80"/>
    <dbReference type="STRING" id="306901.Q2GQ80"/>
    <dbReference type="GeneID" id="4396186"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09874"/>
    <dbReference type="eggNOG" id="ENOG502T0H9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_711724_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQ80"/>
    <dbReference type="OMA" id="FLEIHNT"/>
    <dbReference type="OrthoDB" id="4586997at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="388" mass="43528" checksum="61B7481A0DD771CA" modified="2006-03-21" version="1">MPEFCRLGRESVFPNLLLDAPFRNRQLATQVQHNHTQRPNVPRRASALAGILQEFRRDSPGRACALRYPGVSSVLGAESEVDQHGAAGGTEENIAGLDIIVTNAALMNKIERRDHVTQHLAGIRERAREDDSPWRWEWWKFGMTAEDLFTTLDEKYNTAPYRIQSYEAFHHDVNEIAHEASDLADFHARLALRRDKRLQEMMEAWDSVSRTIIWKTDVLNDNPPRWKAFRNFPWNRSLDSIVQFFQSLLPPPTPPAPRLHEAPSSSGSAAIKPTQTGSPPPLQDTVRSNPAIKTSEASLQPETKPAYPPPPNDARDTRGRKEFKDGQGGNGGHESPTPQPPRHTGAPPSPSTSIPKAKAKTLTRSAGVTKNRHNRLPRQRTPAVRHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQL2</accession>
    <name>Q2GQL2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Redoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_09742</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227669.1">
        <property type="nucleotide sequence ID" value="XM_001227668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQL2"/>
    <dbReference type="STRING" id="306901.Q2GQL2"/>
    <dbReference type="GeneID" id="4396902"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09742"/>
    <dbReference type="eggNOG" id="KOG0541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072440_3_0_1"/>
    <dbReference type="InParanoid" id="Q2GQL2"/>
    <dbReference type="OMA" id="SAWGKQH"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF39">
        <property type="entry name" value="PEROXISOMAL MEMBRANE ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Redoxin" evidence="9">
        <location>
            <begin position="102"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ83338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="184" mass="19529" checksum="8FC29A4E62E50109" modified="2006-03-21" version="1">MFRSTLRPLASMATATTSRRTTTTPLLTTLRPAAAAQSQFHTSPRLLIKPGDPLPDTDALMENTPGQRVNLAEEAQRVNNMLLIGVPAAFSPACSATHVPGMKAWGETLDPAGDQGIRFFADPTGRFTKMLDMAFDGSAIFGGDRSKRYAIVVEQGKVKSVAVEPDNTGTSVSLAEQVLGAVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQP2</accession>
    <name>Q2GQP2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_09712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227639.1">
        <property type="nucleotide sequence ID" value="XM_001227638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQP2"/>
    <dbReference type="GeneID" id="4396099"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09712"/>
    <dbReference type="eggNOG" id="ENOG502RJKT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_188547_3_1_1"/>
    <dbReference type="InParanoid" id="Q2GQP2"/>
    <dbReference type="OrthoDB" id="4835952at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ83308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="53" mass="5596" checksum="BD4B8BBAC94FFC28" modified="2006-03-21" version="1">MALAYPAVDRDAPVKRQNAVTVDVSQPAMSDQTGNVIAFDSTKVYQDAAAKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQR5</accession>
    <name>Q2GQR5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Microbial-type PARG catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_09689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227616.1">
        <property type="nucleotide sequence ID" value="XM_001227615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQR5"/>
    <dbReference type="STRING" id="306901.Q2GQR5"/>
    <dbReference type="GeneID" id="4396688"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09689"/>
    <dbReference type="eggNOG" id="ENOG502S1YN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024412_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GQR5"/>
    <dbReference type="OMA" id="MPWNAQL"/>
    <dbReference type="OrthoDB" id="2440523at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019261">
        <property type="entry name" value="PARG_cat_microbial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596">
        <property type="entry name" value="DUF2263 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596:SF2">
        <property type="entry name" value="MICROBIAL-TYPE PARG CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10021">
        <property type="entry name" value="PARG_cat_microb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microbial-type PARG catalytic" evidence="2">
        <location>
            <begin position="62"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="337" mass="37201" checksum="AF886C4791B56818" modified="2006-03-21" version="1">MPSSSSKSKPKPSEVASEAKRIYIPTIREKYAATWSTCSYIYHQPLLQINFDERPLDLSPPLFYVSSGDPVNVALEWVDSAQCAIPFICAANDKRPGGDWETGVVGYEERLCRRSTLAACLGTPADGSPANSHYPLPICAGVLSQHVVVFRGPHDKYEKLPTDQWRALPVVSVPPPRWPKLTQNGTKYSFADEREMVKEKMRGALRICAYNNYSTVVIGDFGLGNGYRNPPQELAELWREVCLYDPDLRGRIRCVAFVFEDPNQSTTQLILDDIAKKAKGGSGSSRSKTKGSSSSSSSPPGTSPADVDIFSRVFDNTEIQRFLAQPDARYGLSNLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQT4</accession>
    <name>Q2GQT4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NAT10</name>
        <name evidence="15" type="ORF">CHGG_09670</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with TAN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227597.1">
        <property type="nucleotide sequence ID" value="XM_001227596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQT4"/>
    <dbReference type="FunCoup" id="Q2GQT4">
        <property type="interactions" value="994"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GQT4"/>
    <dbReference type="GeneID" id="4396304"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09670"/>
    <dbReference type="eggNOG" id="KOG2036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004652_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQT4"/>
    <dbReference type="OMA" id="HLHYIMS"/>
    <dbReference type="OrthoDB" id="10067491at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA cytidine N4-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11040:FF:000002">
        <property type="entry name" value="RNA cytidine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="12">
        <location>
            <begin position="10"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="11">
        <location>
            <begin position="283"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="539"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="14">
        <location>
            <begin position="774"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="942"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="971"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="971"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="981"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1004"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1035"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1052"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="638"/>
            <end position="640"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="645"/>
            <end position="651"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="739"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ83266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1063" mass="117643" checksum="F55A1A833F4C1076" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQZ2</accession>
    <name>Q2GQZ2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH-ubiquinone oxidoreductase 21.3 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_09612</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227539.1">
        <property type="nucleotide sequence ID" value="XM_001227538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQZ2"/>
    <dbReference type="STRING" id="306901.Q2GQZ2"/>
    <dbReference type="GeneID" id="4396747"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09612"/>
    <dbReference type="eggNOG" id="ENOG502S81D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088319_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQZ2"/>
    <dbReference type="OMA" id="TMMNLRE"/>
    <dbReference type="OrthoDB" id="1913277at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039205">
        <property type="entry name" value="NDUFA11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT"/>
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    </dbReference>
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        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ83208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="21814" checksum="02EABC0F959D31E4" modified="2006-03-21" version="1">MAPTGDDHYHPKDTIHLSLYQGAGFGGIGLLFAAVRNSLSKTNVGPWTTFTKHGGIAATFAVAGTAYEFTRCASANLREKDDYWNHTLGGFVAGAALGLRTGRMPRILGYGVFAAVVTGTYDYAGGTLKGYWNRPEADEYERKETLRKTRRRPIEETIAEIGEGRGIKPPGYEERRRERIKERYGIEINPVNADPDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GR35</accession>
    <name>Q2GR35_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227496.1">
        <property type="nucleotide sequence ID" value="XM_001227495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GR35"/>
    <dbReference type="STRING" id="306901.Q2GR35"/>
    <dbReference type="GeneID" id="4395091"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09569"/>
    <dbReference type="eggNOG" id="ENOG502TDZ6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087355_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GR35"/>
    <dbReference type="OMA" id="EETHHTC"/>
    <dbReference type="OrthoDB" id="3499003at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="23062" checksum="CC07C9B5FF7E5EAC" modified="2006-03-21" version="1">MDQHQAAQQPAQYYALPDAQQEKTGQFQYQQAYELQQHHNTNSPASGPTMLSVTRGVALSVVGVIVFLLVTVIGLSAGLGVSQRDLQQVKGDLEAAQAVLSVTSAPTTAVVLPTSTTASIPAVASPTAKADVQCPRVNGTIYTASSGGKRFRRLCGVDYGGEGEAVDIGNVKTINLDACIDACASETNCTGAGWGVIEGDKGPTHSCWMKTNLTKSHKANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRJ0</accession>
    <name>Q2GRJ0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_09414</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227341.1">
        <property type="nucleotide sequence ID" value="XM_001227340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRJ0"/>
    <dbReference type="FunCoup" id="Q2GRJ0">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GRJ0"/>
    <dbReference type="GeneID" id="4394899"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09414"/>
    <dbReference type="eggNOG" id="KOG3030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021458_6_1_1"/>
    <dbReference type="InParanoid" id="Q2GRJ0"/>
    <dbReference type="OMA" id="WFSYRRY"/>
    <dbReference type="OrthoDB" id="10030083at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000017">
        <property type="entry name" value="Diacylglycerol pyrophosphate phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="127"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ85400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="339" mass="36972" checksum="A8B6D40030E0E7F8" modified="2006-03-21" version="1">MNAKAAAACSLAGKKTYASDYIGFVLLFVSYLLVRLSFTCACLPHLHTRTTSTTSNKPPQFQIQFFVEPFHRMFSLNDLRIAFPHAEVERVPLLHDFIYALFIPLGLVTLTNFLTHAPRHKHHVTLLGLAISLILASLLTDIIKNAVGRPRPDLLARCLPAPNTPRDELVTIAVCTQTHHHTLHDGWRSFPSGHSSFAFAGLGYLALFLAGQMRIFAHAAPGSVGDHAQKLVRGDLVRALVCGAPLLGATMIAISRCQDYRHDVYDVGVGGLLGYTVGYWSYRRYWPRLSSGRCEEPYAGPPAAGEDGVGGGYGRLGDEEEGLGRGRNVGIGLGMLSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRV2</accession>
    <name>Q2GRV2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227229.1">
        <property type="nucleotide sequence ID" value="XM_001227228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRV2"/>
    <dbReference type="GeneID" id="4394854"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09302"/>
    <dbReference type="HOGENOM" id="CLU_672685_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRV2"/>
    <dbReference type="OrthoDB" id="10279690at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="66"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="409" mass="47656" checksum="E5DDDC42994D8C48" modified="2006-03-21" version="1">MNYSAFTPEDDPIPLEKIQPWIDMMRELLLESHLSGDTIMKLMRMYAPKKHHHAIKPIGPTKRRTFHYFSKLPSKVRFTIWRMAAARPPKVLFWQNDYDEGGPPPNSPADGPLAAMACKEAWNVIQHMGFYFDMQGVDPDSSTERARPVQFAHHDLVFTPYGVSTKPCDSEPEFRAHDLLRIRKALAVDYDDFVISMAEGYHPARYNFLAETKQLETLVCIMAAPEVCIWTENDNKDASPGLTGQQLQRTKICQKIVLLQDMEEVRKVDVLWRNVKPEWRWLSRPNCDHFRVNAAAYAPKLQSRCYNCAVRHWKETCVPQLRRTCVRALYTEGFDRLCDEGVREKDPYPEEEIYPHGLTGEPNPNHPWVKKALARMPKFRPAMLLMFKKRAPRYDEMGRCINRMNRKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSI9</accession>
    <name>Q2GSI9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_09065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226992.1">
        <property type="nucleotide sequence ID" value="XM_001226991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSI9"/>
    <dbReference type="GeneID" id="4395704"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09065"/>
    <dbReference type="HOGENOM" id="CLU_1283129_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSI9"/>
    <dbReference type="OrthoDB" id="4757858at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ85051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="215" mass="23818" checksum="3FC8BC4C2AD653F0" modified="2006-03-21" version="1">MGAADWWFRSQTLDMLSSLCANVQELAARGDVVYKILIWDAPGSLMGLKHVTLVQARSRRALDLTVLSQVATTAPNLPTVKFHPVRHTSVFDPPVSLPSMAKLVKLNLPDAYVCHEALLFRPWNPSNTNAPATKLPCFKCHNFQHFSYAQAAEYGPDLEFTPSKAERALVRSTPNLTSLTLYMGQSKHCLRRADVLQSLAGLSKLEDLSLTLLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSL4</accession>
    <name>Q2GSL4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_09040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226967.1">
        <property type="nucleotide sequence ID" value="XM_001226966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSL4"/>
    <dbReference type="FunCoup" id="Q2GSL4">
        <property type="interactions" value="834"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GSL4"/>
    <dbReference type="GeneID" id="4394729"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09040"/>
    <dbReference type="eggNOG" id="KOG0062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_6_1"/>
    <dbReference type="InParanoid" id="Q2GSL4"/>
    <dbReference type="OMA" id="CTHIADI"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071232">
        <property type="term" value="P:cellular response to histidine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042327">
        <property type="term" value="P:positive regulation of phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071264">
        <property type="term" value="P:positive regulation of translational initiation in response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006448">
        <property type="term" value="P:regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000882">
        <property type="entry name" value="Translation initiation regulator (Gcn20)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF117">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="197"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="529"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ85026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="749" mass="82580" checksum="B32A919E54E7FC5F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GST7</accession>
    <name>Q2GST7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TATA-box-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_08967</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226894.1">
        <property type="nucleotide sequence ID" value="XM_001226893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GST7"/>
    <dbReference type="STRING" id="306901.Q2GST7"/>
    <dbReference type="GeneID" id="4395556"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08967"/>
    <dbReference type="eggNOG" id="KOG3302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172174_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GST7"/>
    <dbReference type="OMA" id="CTRSKRI"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000120">
        <property type="term" value="C:RNA polymerase I transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097718">
        <property type="term" value="F:disordered domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001179">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000979">
        <property type="term" value="F:RNA polymerase II core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001092">
        <property type="term" value="F:TFIIA-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001188">
        <property type="term" value="P:RNA polymerase I preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ84953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="84" mass="9687" checksum="0D2CAEEF6D17884C" modified="2006-03-21" version="1">MVNIVGSCDIKFPIRLEGLASKHHNFSSYEPELFPGLIYRMIKPKIVLLIFVSGKIVLTGAKVREEIYQAFEMIYPVLQDFRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSX3</accession>
    <name>Q2GSX3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peroxisomal biogenesis factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_08931</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226858.1">
        <property type="nucleotide sequence ID" value="XM_001226857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSX3"/>
    <dbReference type="FunCoup" id="Q2GSX3">
        <property type="interactions" value="199"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GSX3"/>
    <dbReference type="GeneID" id="4394927"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08931"/>
    <dbReference type="eggNOG" id="KOG4186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049216_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSX3"/>
    <dbReference type="OMA" id="AYHPTVA"/>
    <dbReference type="OrthoDB" id="411017at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF50">
        <property type="entry name" value="PEROXIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ84917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26382" checksum="8AE7855372EFFA1E" modified="2006-03-21" version="1">MVADTLIYHPAVSHYLKFVATTVGRDKLLRTLQYFARFYAWYLLRTNKTQASIQPWETMKKQFGLIRKVLRAGKNVEHFKAAAVAADASKTADPVLRYTAVGRQLGYAGYLTMDLGTVLDATGIRKSPRAKRLQQEAYRFWAFGIACSVIAQMYTLRQLRLREATVDRKEGEGVLEGKRIAMERAASRLQLTSDLCDLTVPLSALSWVHFDDGIVGLAGTLSSLIGVYLQWKKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTC8</accession>
    <name>Q2GTC8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_08776</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226703.1">
        <property type="nucleotide sequence ID" value="XM_001226702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTC8"/>
    <dbReference type="STRING" id="306901.Q2GTC8"/>
    <dbReference type="GeneID" id="4395716"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08776"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_5_1"/>
    <dbReference type="InParanoid" id="Q2GTC8"/>
    <dbReference type="OMA" id="QITFNFP"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="11"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ84762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="335" mass="35485" checksum="FC4B102E9406F8E1" modified="2006-03-21" version="1">MHSAAVLLKEGGPLVVDERITPEPGPTDVLIEVKAVALNPMDYLQRDTNFPPIPFYPAVIGCDAAGVIAKVGSEVTTVVPGTRVLAFVTPFYQNGSPDYGAFQKYALAPFETAVPLPDALSFEEGAVLPVAAVTALTAWTTIGIPISTRHTPQDKQGVLIWGGASSIGSFSVQTARILGFTVYTTASPKHHAYLKGLGADAVFDYKDSDVVAQIVAAVKKDGVKLHTAHCAVPDSLQPTLDVLKETKGDAPARVAHSPVLLPDHPTLDNTEIKFNFPSGDKAERDRHMYGCFHEWLQENLKSGAVVPSPGIQVEGGGLDGLNAALDKLKAGDYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTS0</accession>
    <name>Q2GTS0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_08634</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226561.1">
        <property type="nucleotide sequence ID" value="XM_001226560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTS0"/>
    <dbReference type="STRING" id="306901.Q2GTS0"/>
    <dbReference type="GeneID" id="4395604"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08634"/>
    <dbReference type="eggNOG" id="ENOG502S4TA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078549_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GTS0"/>
    <dbReference type="OMA" id="PLIRCDV"/>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12467">
        <property type="entry name" value="RRM_Srp1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000123">
        <property type="entry name" value="Pre-mRNA splicing factor (Srp1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034403">
        <property type="entry name" value="Srp1p_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952:SF5">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="6"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ84620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="195" mass="23456" checksum="A95DBB0E8AC91EB1" modified="2006-03-21" version="1">MSRNGTTLYVSGFSHGTRARDLAYEFERYGRLVRCDIPAPRSASSRLFAFVEYEDRRDADDAYHDMHNKRIGRDDVLKIEWARTPPSASWRFDRSERERGPRRSSPRRRSPSPRRRDYSPRKDDRRDRDRDRDYDRDRRDTRDRSRSPDRDRDRDTKDDRDRDERDRRENGANGDDRKPIDSPDRPAHDDLDVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU39</accession>
    <name>Q2GU39_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226442.1">
        <property type="nucleotide sequence ID" value="XM_001226441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GU39"/>
    <dbReference type="GeneID" id="4395121"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08515"/>
    <dbReference type="HOGENOM" id="CLU_676145_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GU39"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="407" mass="45101" checksum="AC72D9FE154EEDED" modified="2006-03-21" version="1">MPSVLCACPSPRPSLLPLEGRLGQKLDRFWSASGELRRSCQMEPKLSTPLRMRWPTGSLPLELQHLFPSFPTPVLQSSSSPQQSSRSLATGLGHGAHGCPGRRSVLRNSRFQDPTAMVGASGVWGDAGRSRDQLHPVFPVSIQYKMWSLKTWPDGLIGFGDGLKGSDPDKRCANEELLVSVAAVKGPDCPTRRSVIELYDLQERTGRICCHSSPSQCSSPHQSPISRDARRDFIRDLRQGARIFVTGSTPEALSLSERLSICRFRFFPLSPQPPPTVARDFRSGLSQGMRAGQPPPSSYRPARCQLRGRLPNGRATPASEMSWFSSHSCSQTFLTLELFELLCILVRLLEGTLRGTQSSNRGQVRANHSERQTLPWWVIEAGQALPHIVVEFETDMVDEGKHKSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUB6</accession>
    <name>Q2GUB6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">L-rhamnose-1-dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_08438</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226365.1">
        <property type="nucleotide sequence ID" value="XM_001226364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUB6"/>
    <dbReference type="STRING" id="306901.Q2GUB6"/>
    <dbReference type="GeneID" id="4395884"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08438"/>
    <dbReference type="eggNOG" id="KOG1200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GUB6"/>
    <dbReference type="OMA" id="WEVANVI"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000417">
        <property type="entry name" value="Glucose 1-dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF83">
        <property type="entry name" value="(3R)-3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0684">Rhamnose metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ84424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="28000" checksum="D8497712C4DC9A9C" modified="2006-03-21" version="1">MPATNLLAGKTAIITGGTTGIGRAIALAFLAQGCNVAVNHLDLPTDKPHLTSLLAEASALHTANPTTTGRLAHLPGDVRDPSTGPALVAFALAHFATTRLDICVSNAGVCTFADLLDLSPDLFATTVRTNLDGAFYVVQAAARQMARDNVPLGGGSIIAVSSISALVGGGQQVHYTPTKAGVLSLMQSAAVALGKYGVRCNALLPGTVRTQLNEADLADEGKRRYMEGRIPLGRTGVPTDVAGPAVFLACDELSGYVTGAQLLVDGGLFVNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUH4</accession>
    <name>Q2GUH4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_08380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226307.1">
        <property type="nucleotide sequence ID" value="XM_001226306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUH4"/>
    <dbReference type="STRING" id="306901.Q2GUH4"/>
    <dbReference type="GeneID" id="4394710"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08380"/>
    <dbReference type="eggNOG" id="KOG1304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009646_3_2_1"/>
    <dbReference type="InParanoid" id="Q2GUH4"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF332">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="204"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="336"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ84366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="490" mass="53080" checksum="A13BA1E5A6D444B2" modified="2006-03-21" version="1">MSDLRGTSRDRRDTEALAQVVAEHLPSGYTAEFDSTAGSTDGATPASAEGSDVVPIPEEESSLKLQGGDMHRDLFRLPSAATRVPMHRRAATFHSPRDLHPDDDAPPLTVGDQLAPGGFRRAFLHQRHGNDFMAARLPITRNFVEFLDLYGSFAGEDLVDTDEEAVTEEEEEQGEGVEEEMVGERRPLLRQRISSVRTPRSANAGTVKTFFTLLKAFIGTGIMFLPKAFRNGGILFSTVSMLSVSAVTMVAFHLLLQCKLHHGGGYGDIGNAIAGPRMRTLILFSIALSQLGFVCAGIVFVAENLETFFHAVTGGQNPFTSAGLIAMQLIILDSPLVNSVQLLYAIAVLVGTPVQLFPALRILEGKIFGHMRSGKGSLRTKWVKNLFRVGVVVFCGLVSVAGTGNLDRFVALIGSVACVPLVYVYPAFLHYRGVATQRTFACVSMMMICATLVVGYPWISAGQSTPDPPPQLHKGELIENVRFMGSSVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUQ4</accession>
    <name>Q2GUQ4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycosyl hydrolase family 30 beta sandwich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_08300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ87047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225956.1">
        <property type="nucleotide sequence ID" value="XM_001225955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUQ4"/>
    <dbReference type="STRING" id="306901.Q2GUQ4"/>
    <dbReference type="GeneID" id="4394463"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08300"/>
    <dbReference type="eggNOG" id="KOG2566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031530_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GUQ4"/>
    <dbReference type="OMA" id="SKRFWAF"/>
    <dbReference type="OrthoDB" id="2012278at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039514">
        <property type="entry name" value="6GAL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14587">
        <property type="entry name" value="Glyco_hydr_30_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208650" description="Glycosyl hydrolase family 30 beta sandwich domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Endo-beta-1,6-galactanase-like" evidence="5">
        <location>
            <begin position="28"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="6">
        <location>
            <begin position="378"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ87047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="50731" checksum="73FB232B4865A965" modified="2006-03-21" version="1">MHSLYLVTILGLALGMKAMIIEPRQATGITVDLGKTYQTMDGFGTSEAFQRALTMKRLSETEQRKFLDLMFSMDKGAGLSILRNGIGSSPDMSDDHMVSIQPRNPGGPNAEPKYVWDESDNGQLWVSTEAAHTYGVKTFYANAWSAPGYMKTNGNDANGGSLCGVSGASCSSGDWKQAFANYLVQYIKYYAAANVSITHLGFLNEPDYTTSYASMRSSGSQAADFIQVLRPTLDRNGLASVIINCCDTMGWTVMNSMLSQMGSTQSILGTVTGHSYTSSPTSQLSTKLKTWMTEGADNNGAWTSAWYSNGGAGEGMTWANNIYSAITGGNVSAYLYWIGGQDRSSNTNSKMIRVVNRQVDPSKRLWAMANWSRFVRPGAVRVGASGSGVRTTAFRNVDGMVSVQVINSGGERAVTITVGGGDFVATNATAWVTDNTRDCNPIAATVDATGKVSGSVPSRSMVTFVLRPASAAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUT1</accession>
    <name>Q2GUT1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ87020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225929.1">
        <property type="nucleotide sequence ID" value="XM_001225928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUT1"/>
    <dbReference type="STRING" id="306901.Q2GUT1"/>
    <dbReference type="GeneID" id="4394505"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08273"/>
    <dbReference type="eggNOG" id="ENOG502SQE7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031973_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUT1"/>
    <dbReference type="OMA" id="KRFREWN"/>
    <dbReference type="OrthoDB" id="5308957at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="653" mass="71529" checksum="08B1298FF3F86099" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVA6</accession>
    <name>Q2GVA6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_08098</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ATX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225754.1">
        <property type="nucleotide sequence ID" value="XM_001225753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVA6"/>
    <dbReference type="FunCoup" id="Q2GVA6">
        <property type="interactions" value="510"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GVA6"/>
    <dbReference type="GeneID" id="4394515"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08098"/>
    <dbReference type="eggNOG" id="KOG1603">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134973_3_1_1"/>
    <dbReference type="InParanoid" id="Q2GVA6"/>
    <dbReference type="OMA" id="MTHTYKF"/>
    <dbReference type="OrthoDB" id="689350at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000008">
        <property type="entry name" value="Copper transport protein ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051881">
        <property type="entry name" value="Copper_transport_ATOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365:SF1">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="HMA" evidence="9">
        <location>
            <begin position="13"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ86845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="96" mass="10267" checksum="EDADB878DA28B267" modified="2006-03-21" version="1">MADVVAASPDAVEHKYQFNVSMSCGGCSGAVDRVLKKLEGVKSYEVSLESQTATVVAEESLTYEKVLRTIKKTGKKVNSGEADGVEKSVELPAEEQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-24" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVT8</accession>
    <name>SEC31_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Protein transport protein SEC31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SEC31</name>
        <name type="ORF">CHGG_07916</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225572.1">
        <property type="nucleotide sequence ID" value="XM_001225571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVT8"/>
    <dbReference type="SMR" id="Q2GVT8"/>
    <dbReference type="FunCoup" id="Q2GVT8">
        <property type="interactions" value="681"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GVT8"/>
    <dbReference type="GeneID" id="4394267"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07916"/>
    <dbReference type="eggNOG" id="KOG0307">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003033_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GVT8"/>
    <dbReference type="OMA" id="WLERPCG"/>
    <dbReference type="OrthoDB" id="542917at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000193">
        <property type="entry name" value="Protein transport protein SEC31, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0931">ER-Golgi transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000295434" description="Protein transport protein SEC31">
        <location>
            <begin position="1"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="6"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="65"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3">
        <location>
            <begin position="117"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4">
        <location>
            <begin position="161"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5">
        <location>
            <begin position="204"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 6">
        <location>
            <begin position="251"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 7">
        <location>
            <begin position="294"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 8; interaction with SEC13" evidence="2">
        <location>
            <begin position="375"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="470"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="792"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="792"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="845"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="896"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="963"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1035"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1061"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1083"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1135"/>
            <end position="1144"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="1258" mass="134167" checksum="01A7F0982C5C4321" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWA7</accession>
    <name>Q2GWA7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225403.1">
        <property type="nucleotide sequence ID" value="XM_001225402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWA7"/>
    <dbReference type="STRING" id="306901.Q2GWA7"/>
    <dbReference type="GeneID" id="4393421"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07747"/>
    <dbReference type="eggNOG" id="ENOG502SSMU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020691_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWA7"/>
    <dbReference type="OMA" id="YESTCAL"/>
    <dbReference type="OrthoDB" id="5339332at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="505"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="655" mass="68272" checksum="7E69E981C9D31377" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWJ8</accession>
    <name>Q2GWJ8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_07656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225312.1">
        <property type="nucleotide sequence ID" value="XM_001225311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWJ8"/>
    <dbReference type="GeneID" id="4393922"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07656"/>
    <dbReference type="HOGENOM" id="CLU_2573670_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWJ8"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ86403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="81" mass="9368" checksum="136089753DC5E0AD" modified="2006-03-21" version="1">MYYSAQFREQCLFQLNPPRPVGDTKLQILRCQAGGNELTDHWCNQTRRAADDIGCRAVISFKDGTIQRMTCKAKVNQRFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWR7</accession>
    <name>Q2GWR7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_07587</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225243.1">
        <property type="nucleotide sequence ID" value="XM_001225242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWR7"/>
    <dbReference type="STRING" id="306901.Q2GWR7"/>
    <dbReference type="GeneID" id="4394648"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07587"/>
    <dbReference type="eggNOG" id="ENOG502RXMI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031730_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWR7"/>
    <dbReference type="OMA" id="YIDSPPN"/>
    <dbReference type="OrthoDB" id="2525337at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF17">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208685" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="20"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="20"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ86334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="243" mass="26703" checksum="735214A9F992203D" modified="2006-03-21" version="1">MLVLTLTTALLALAHHASAHATVFRVSVNGKDQGDGVNKYIRTPATNDPVRDLADPSLVCNTAGGKEVGSSVKAASGDKLTFHWWHYNPDDPADYPLDPSHKGAILTWIANYTAEGGTGALWTKLAEEGFDGGKWATIKMIENKGAVDFQLPKALAKGKYLIRQEIIALHMADGRGDDPARPDRGAEFYPNCVQFEVTGDGNAVPDQEFDFNKDYKYDDKGLFFNIYIPFDKYTPPGPRPWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWX0</accession>
    <name>Q2GWX0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CHGG_07534</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225190.1">
        <property type="nucleotide sequence ID" value="XM_001225189.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2GWX0">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="GeneID" id="4393622"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07534"/>
    <dbReference type="eggNOG" id="KOG0342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004419_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWX0"/>
    <dbReference type="OMA" id="VAKSVPY"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17964">
        <property type="entry name" value="DEADc_MSS116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="420"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="494"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="607"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="690"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="722"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="756"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="808"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="876"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="907"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="1114"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1356"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="876"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="1362"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1408"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="1426"/>
            <end position="1453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAQ86281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1481" mass="163482" checksum="D5E13D7BBA3D2640" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX13</accession>
    <name>Q2GX13_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_07491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225147.1">
        <property type="nucleotide sequence ID" value="XM_001225146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX13"/>
    <dbReference type="GeneID" id="4394619"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07491"/>
    <dbReference type="HOGENOM" id="CLU_2346501_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GX13"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ86238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="97" mass="10501" checksum="7528DBE5FFCE9DEE" modified="2006-03-21" version="1">MAGPTLEIRLSSQRQQAVDPLSLAQVAPRPCHGLGLDQALQPIHPTMVAARATGEMVRREAGDSRGSLAVNIDGWAPNWAYRCHIPPFSGANGYRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX64</accession>
    <name>Q2GX64_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_07440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="protein sequence ID" value="EAQ86187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_001225095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX64"/>
    <dbReference type="STRING" id="306901.Q2GX64"/>
    <dbReference type="GeneID" id="4393781"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07440"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="InParanoid" id="Q2GX64"/>
    <dbReference type="OMA" id="WWASWLY"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209097" description="Major facilitator superfamily (MFS) profile domain-containing protein" evidence="7">
        <location>
            <begin position="31"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="21"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ86187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="505" mass="55062" checksum="295D893DDFCE1EFC" modified="2006-03-21" version="1">MTTPPPAARSRLLAEKRVVLLSFLIALGQFQYGYDSAAVAGFQSLPGFLEVYGYVDASNPIGLNISTDVQRLIQSLMNVGGFVAAVAIYFAHARVSRRVGLWVGCGFAFLSISLQLGLHSLGGLYAGRLLLGVSNGFLVPYCVTYMTEAAPSMLRGPIVGMSTFQTSLGALFGILVDNYCQPYGGTASWKIPLGVMYIVPAFLTVLLLFLPDTPRFYVTQGREDKAMRAIRRLRGIKDEELLRAEVEDIKSAFLMEQEIHAGVHLTDMFRGSDLRRTLLSYGANIAGIATGVTFMAGFSVYLFVQARVGSPFAWVMISLAIALTGNMLAFPAMRYFGRRELLVVTSVLSSAMMFGMAIVYTASGGHSSAASKALVALSIVYTWVYGVGQGPVLWALGTEIPSQRLRSQTVGTASGLNFIVGWLVSFFTPYFINPDHLGWGPKYGYIWGGSNLVVAVWAFFFVPETKGRSLEQLDELFEKRTRHLELAKLWGKGLAGASLQNCPWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX96</accession>
    <name>Q2GX96_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225064.1">
        <property type="nucleotide sequence ID" value="XM_001225063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX96"/>
    <dbReference type="GeneID" id="4394118"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07408"/>
    <dbReference type="HOGENOM" id="CLU_3335509_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GX96"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="38" mass="3811" checksum="E385C04610F69840" modified="2006-03-21" version="1">MVGSGGADDAARSADPIPADDSGAGAEPERNIPREEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXC5</accession>
    <name>Q2GXC5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225035.1">
        <property type="nucleotide sequence ID" value="XM_001225034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXC5"/>
    <dbReference type="GeneID" id="4393528"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07379"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_23_6_1"/>
    <dbReference type="InParanoid" id="Q2GXC5"/>
    <dbReference type="OrthoDB" id="416454at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="231"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="712" mass="79411" checksum="15FCDDC7AF156B9B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXL9</accession>
    <name>Q2GXL9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224941.1">
        <property type="nucleotide sequence ID" value="XM_001224940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXL9"/>
    <dbReference type="GeneID" id="4394277"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07285"/>
    <dbReference type="HOGENOM" id="CLU_1777213_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GXL9"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="146" mass="16466" checksum="5E75BA53210469C6" modified="2006-03-21" version="1">MTTACPKHDQICHLISAEPRPSPMDHAPHLIRELAAVHPHDLYLHTYIQGAAAGGQISDGPPCFRICQIRRLASRPGVPDPQLFSGQENRALPGRVKNPYQQSRNDAFCYVKDPRTRKDVKGYLDEKATYNYPTNCPTPTRFDNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXW3</accession>
    <name>Q2GXW3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_07191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224847.1">
        <property type="nucleotide sequence ID" value="XM_001224846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXW3"/>
    <dbReference type="GeneID" id="4394542"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07191"/>
    <dbReference type="HOGENOM" id="CLU_1669182_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GXW3"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ85938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="158" mass="17573" checksum="EDB316CFBE279B0F" modified="2006-03-21" version="1">MSIRINSTHRVAWRGERARDPFEDHAHALAALAKLILRLGRCERLDAALDAPGAQSCKEPAAAFVHGRFCLCLCLPQPVPDTLAQPGAEHHPGLDICVVCCRLRLGHGIELSLNYREHANKVEVPAFRRHPSLAHVHDARLKDVRCLVRRAPRQGRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYM8</accession>
    <name>Q2GYM8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_06926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224582.1">
        <property type="nucleotide sequence ID" value="XM_001224581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYM8"/>
    <dbReference type="STRING" id="306901.Q2GYM8"/>
    <dbReference type="GeneID" id="4393980"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06926"/>
    <dbReference type="eggNOG" id="ENOG502SS6E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_442785_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYM8"/>
    <dbReference type="OrthoDB" id="5430750at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ85673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="617" mass="70151" checksum="E08A31C52B3508E0" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYQ7</accession>
    <name>Q2GYQ7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_06897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224553.1">
        <property type="nucleotide sequence ID" value="XM_001224552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYQ7"/>
    <dbReference type="STRING" id="306901.Q2GYQ7"/>
    <dbReference type="GeneID" id="4393135"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06897"/>
    <dbReference type="eggNOG" id="ENOG502RXTA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014722_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYQ7"/>
    <dbReference type="OMA" id="RIYSSHR"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF6">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208298" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="61"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ85644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="387" mass="42016" checksum="A562623D9A3B2678" modified="2006-03-21" version="1">MALTIATLAVAGLAAAAHAADPPQPTPSEPPFSYPGIPPYNGTGPTLLRFGCHQVVVDRIDPLVNPGSIPSPHQHQIVGGDAFNASMPVSDISDLSTCTTCSYSDDFSNYWTSNLYFRARNGSYKRVPQIPNRLFFDDEFTTRINGGMIAYYVSPGKGEVKAFEPGFRMFVGDAALRSEPQGRWNLSTQSCFRCYTGPNWEGDDYAPCQDANVDTQHLPNRPCHGIRTNVIFPTCWDGKNLDSPDHTAHVAYPVEGPHVFDGIGTAETCPDSHPVKIPQVMYEIVWDTSGFNDPNEWPEDGSQPFVLSTGDRTGYSQHADYVFGWKGDALQRAMDAGCIAANCPGIATQTVEKAAKCKVAEVVGENYDGWLDTLPGNPPQPSATTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYU3</accession>
    <name>Q2GYU3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ornithine decarboxylase antizyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_06861</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with ODC and thereby sterically blocks ODC homodimerization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ODC antizyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224517.1">
        <property type="nucleotide sequence ID" value="XM_001224516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYU3"/>
    <dbReference type="STRING" id="306901.Q2GYU3"/>
    <dbReference type="GeneID" id="4394086"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06861"/>
    <dbReference type="eggNOG" id="ENOG502S3W3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086393_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GYU3"/>
    <dbReference type="OMA" id="RLFCETM"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008073">
        <property type="term" value="F:ornithine decarboxylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279:SF10">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0688">Ribosomal frameshifting</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ85608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="311" mass="33459" checksum="BFD65A6C26E33ED3" modified="2006-03-21" version="1">MAPMKSPKSNSSSNYGEDVARQANILASCYGPSGIPEVPSTGLPSPPSSPPLAALTSTNQLALTPKARSSSARGHSVGRHGSDTTNDTSSSAWHRRRGGATLRIREECERFFCETLRAMLLGERNAALQGSGLASVHSNNNYYSNGSYNDSISNNASRNDGRAQAVGHYGQLTPPTDFPIMDETMMGRRRLGAAGGVLGWLEIWDYAGGASFRGFVAEDSTGETKSLFVFFDEHSITGDLKQALVALIELAEGPLDCSHMVICIERSIPAEEINGLAKGLQWAGFSLTTLDFWSPGFDVLSNRWLFMGMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYY1</accession>
    <name>Q2GYY1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Two-component system protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_06823</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224479.1">
        <property type="nucleotide sequence ID" value="XM_001224478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYY1"/>
    <dbReference type="STRING" id="306901.Q2GYY1"/>
    <dbReference type="GeneID" id="4393585"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06823"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_15_1"/>
    <dbReference type="InParanoid" id="Q2GYY1"/>
    <dbReference type="OMA" id="VGFHANP"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000136">
        <property type="entry name" value="Sensor histidine kinase/response regulator Fos-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="153"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="228"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="294"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="559"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ85570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="747" mass="82288" checksum="F507DEF261E3E7C0" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZ41</accession>
    <name>Q2GZ41_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_05205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224419.1">
        <property type="nucleotide sequence ID" value="XM_001224418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZ41"/>
    <dbReference type="FunCoup" id="Q2GZ41">
        <property type="interactions" value="78"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GZ41"/>
    <dbReference type="GeneID" id="4391856"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05205"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="InParanoid" id="Q2GZ41"/>
    <dbReference type="OMA" id="RTHDKGR"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="46"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ88586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="317" mass="35253" checksum="4A62FA5FA614E485" modified="2006-03-21" version="1">MSTNDTQPPSKGKVLLTGGTGFIASHVLDCLLDHGFDVVVTVVVSSPPIDYVVHTASPYRMRWEDPKKECLDPAINGISGLLNSLYRYAPGVKRVVFTSSSAAMLDPPNHPKVYDESCWCKVTSQEAMDPANTYRASKTFAERYAWDFYKRHPDKFTLATINCTYTFGPLPRSLDSLDNLNTSNHRIRNLVQGRMREGMPPTAPVFTFVDVRDVALAHVRAMTVPDAAEKRFYVVGGFFSNYLIASIVRCRFPQLETLLPPAENVKDDFPEEHWAFDNSRSKEVLGLEYTGLEKTVVDTVESILAFNGAGGKSTGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZE9</accession>
    <name>Q2GZE9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224311.1">
        <property type="nucleotide sequence ID" value="XM_001224310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZE9"/>
    <dbReference type="STRING" id="306901.Q2GZE9"/>
    <dbReference type="GeneID" id="4391965"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05097"/>
    <dbReference type="eggNOG" id="ENOG502S5KH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_268135_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZE9"/>
    <dbReference type="OrthoDB" id="5421041at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF40">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="431"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1091"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1165"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="523"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1174"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1191"/>
            <end position="1217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1226" mass="136379" checksum="EDDF891595A15CFD" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZL8</accession>
    <name>Q2GZL8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Survival factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_05028</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224242.1">
        <property type="nucleotide sequence ID" value="XM_001224241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZL8"/>
    <dbReference type="FunCoup" id="Q2GZL8">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GZL8"/>
    <dbReference type="GeneID" id="4392429"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05028"/>
    <dbReference type="eggNOG" id="ENOG502QQY3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030205_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GZL8"/>
    <dbReference type="OMA" id="AFWPRCV"/>
    <dbReference type="OrthoDB" id="2590239at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051385">
        <property type="entry name" value="Ceramide-binding_SVF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033394">
        <property type="entry name" value="Svf1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013931">
        <property type="entry name" value="Svf1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107:SF1">
        <property type="entry name" value="CERAMIDE-BINDING PROTEIN SVF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107">
        <property type="entry name" value="SVF1-LIKE PROTEIN YDR222W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08622">
        <property type="entry name" value="Svf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17187">
        <property type="entry name" value="Svf1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Svf1-like N-terminal" evidence="4">
        <location>
            <begin position="55"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Svf1-like C-terminal" evidence="5">
        <location>
            <begin position="216"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ88409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="42020" checksum="2BFBB9250ACB8D47" modified="2006-03-21" version="1">MFKWAQQQLANVAGTQEPIYGASAIKSVAEEAETTPYSELTRDDLKWQAMESTSVETQTFYFMSDSGQLAFAQVIYSNVAGIRTTCQFNCKVFSLDGSKPHLWSTTQLSNHDFSEDRTGFYADDCAVELSEDGTTYTIKSMNDDKAIVNLTVKRTAPGFKAGKTGNTLFGTDLSNPWGSMRHIFWPRCTAEGTVTTKEGPIDFKGKAFFSYALQGMKPHHAAAKWNFCNFQGPKYSAILMQFTTPPSYASTVVNVGVIAKDGEIIVGGCKSNVTHIQTKSDSENDWPEPTTIKYTWAGTTKDGKPVEAFIEGGLEEKLDRIDVMAEVPGFVKKIVAGAAGTKPYIYQYSPQKTKLSLKLKIGDEEFSEEGFVFSEATFISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZW1</accession>
    <name>Q2GZW1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224149.1">
        <property type="nucleotide sequence ID" value="XM_001224148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZW1"/>
    <dbReference type="GeneID" id="4391764"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04935"/>
    <dbReference type="eggNOG" id="ENOG502S0M4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_812743_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZW1"/>
    <dbReference type="OMA" id="YATNAKQ"/>
    <dbReference type="OrthoDB" id="4762260at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208652" evidence="2">
        <location>
            <begin position="19"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="386" mass="40861" checksum="2114E3BE8964AEC7" modified="2006-03-21" version="1">MVGSTLALSLIGLSAVQALPTAKTVEERQIWIGPGSGTFIPGQGELPPCLTDQPLQGQPPCLLPPIVGPINPSTKREVGKRQIWIGPGSGTFIPGPGELPPCLVDQPLQGQPPCLLPPIVGPIVPSTKAKRQISIGDGTGVFIPGQGEVPICLTDVPLNEQPPCMLPPIVGGIEPSTKKRGFVLPPDATTNPKKVIITLEKELIRLQNKKNKTQQDRDDIAAIKAALKFLAGITNISAPPGTGSTFTPGKRSFTLPPDALTNTKEVIKTLERELIRLQNKRNKSAEDIDDIEAIKGALYYLAGITNISAPPGTGSTFTPGKRDGGSVIQCPNLNGAQIALETLMHKDKHTPEEAIIMEKLAAFLKSCGIIIVKSPDGTFTTIKPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H040</accession>
    <name>Q2H040_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224070.1">
        <property type="nucleotide sequence ID" value="XM_001224069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H040"/>
    <dbReference type="GeneID" id="4392801"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04856"/>
    <dbReference type="eggNOG" id="ENOG502SNEF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_785270_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H040"/>
    <dbReference type="OrthoDB" id="4566274at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="353" mass="41408" checksum="9734CE450325A34A" modified="2006-03-21" version="1">MSAISSSSRTLRNGFLSIQPTKFATPLDYAYYQYRLLDESLRLPPEKLSQQVAELEVFALQDLKNRLPNIVENQHPFVLTHTDLRPTNIIVDENMQIQGIIDWEWARTVPRQFFLPPTWIAGCPPDMVSGVEFRIEYRWLRDVLWADTSEHCRQLASEWNRKLPRRIDMSLAVIFGHHSSFVNAYYRGVFPMFYESSWGQEVKQFYECDGPDGKFSLDVQQRLRESKRYAQYLEKLGPLLVLLKLFKFIQRHIIQVPLQFLKLDPPQFKLLFRLIHLFIDLHDPFPGVYDRVGDVDGRTPMTLFCRPRCTSRDHIEDIWVDGCDESILPNQLVLQLSAQLPLLFDRLDFGSNL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-05" modified="2025-04-09" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H080</accession>
    <name>RM04_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL29m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>54S ribosomal protein L4, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MRPL4</name>
        <name type="ORF">CHGG_04816</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial large ribosomal subunit. Mature mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S subunit contains at least 33 different proteins and 1 molecule of RNA (15S). The 54S subunit contains at least 45 different proteins and 1 molecule of RNA (21S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224030.1">
        <property type="nucleotide sequence ID" value="XM_001224029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H080"/>
    <dbReference type="SMR" id="Q2H080"/>
    <dbReference type="STRING" id="306901.Q2H080"/>
    <dbReference type="GeneID" id="4392928"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04816"/>
    <dbReference type="eggNOG" id="KOG3331">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063281_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H080"/>
    <dbReference type="OMA" id="YAHGRAW"/>
    <dbReference type="OrthoDB" id="270763at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038340">
        <property type="entry name" value="MRP-L47_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010729">
        <property type="entry name" value="Ribosomal_uL29_mit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183:SF18">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183">
        <property type="entry name" value="RIBOSOMAL PROTEIN L47, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06984">
        <property type="entry name" value="MRP-L47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end status="unknown"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000372398" description="Large ribosomal subunit protein uL29m">
        <location>
            <begin status="unknown"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="227"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="272" mass="30552" checksum="AADC2693D75AD29E" modified="2006-03-21" version="1" precursor="true">MAAAAMRPSMGALGRISSSTPSPLRPLTQTASLSTTAALLKRHKYREARVYRDNSKHRGESAIHRSGTRWRLSMSDEPLPRPVPRNKLPAIETDPDHGLWEFFQNRTMVVNSPPEIAKHGRSWTAEELRHKSWDDLHRLWWVCAKERNRIATANWERNKSGLGFGEAEMRERDNAVRQTMRSIKHVLTERFYTWEDAVKVAEKDPEVDLTGNGPAFTPSNFLEDSDAAATEGEQQAAEATEEAVEKAEPATAATPESATIPSSQQQTDTPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H110</accession>
    <name>Q2H110_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF292-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223750.1">
        <property type="nucleotide sequence ID" value="XM_001223749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H110"/>
    <dbReference type="FunCoup" id="Q2H110">
        <property type="interactions" value="686"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H110"/>
    <dbReference type="GeneID" id="4392474"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04536"/>
    <dbReference type="eggNOG" id="KOG2027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037652_4_1_1"/>
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    <dbReference type="OrthoDB" id="29853at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099638">
        <property type="term" value="P:endosome to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.60:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein IST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.60">
        <property type="entry name" value="Vacuolar protein sorting-associated protein Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005061">
        <property type="entry name" value="Ist1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042277">
        <property type="entry name" value="IST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161">
        <property type="entry name" value="IST1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161:SF5">
        <property type="entry name" value="IST1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22379" checksum="BF6DBB053EEFA064" modified="2006-03-21" version="1">MPPSSPTLVPKIKVQLKLSIARLRMVQKRDEALAKTQRRAMATLLEQGKTDSARIRVENIIRSDIITELHEVLELYCELLLARAGLLDAPPPCDPGLEEAIKSVIYAAPKTEIKELGAVRALLAEKFGKEFVLQAMENEDGRVSERVVRKLSVAPPREELVQGYLEEIAKAYGVDWPPGRRAEEALGEPPGFVDGEDGEDDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H124</accession>
    <name>Q2H124_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ87903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001223735.1"/>
    </dbReference>
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    <dbReference type="STRING" id="306901.Q2H124"/>
    <dbReference type="GeneID" id="4392842"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04522"/>
    <dbReference type="eggNOG" id="KOG0274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009186_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H124"/>
    <dbReference type="OMA" id="GPHPTYE"/>
    <dbReference type="OrthoDB" id="2095648at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF2">
        <property type="entry name" value="F-BOX AND WD DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11400)"/>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="881"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="971"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="884"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="895"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="975"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1117" mass="118523" checksum="EFB3382565106A78" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1N6</accession>
    <name>Q2H1N6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_04310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223524.1">
        <property type="nucleotide sequence ID" value="XM_001223523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1N6"/>
    <dbReference type="GeneID" id="4392039"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04310"/>
    <dbReference type="HOGENOM" id="CLU_1586274_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H1N6"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ87691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="168" mass="19054" checksum="5388279A4F03530D" modified="2006-03-21" version="1">MEMCLPWARAHWTTSCHVQVLPVLVQGRDDSQTVYEGRLARRCIKALTEPLEVQLGLLAVAQAPEEAPKPWGNHAARNLLLEDDNGCELEEQPVRCEMLRQAFRSLSATVPGRRQEEAGLQDGVELEEVPEEQDHWDPAKRVITLSGANQKQEVYSGKKRGRDYTIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2C0</accession>
    <name>Q2H2C0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_04076</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223290.1">
        <property type="nucleotide sequence ID" value="XM_001223289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2C0"/>
    <dbReference type="STRING" id="306901.Q2H2C0"/>
    <dbReference type="GeneID" id="4392618"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04076"/>
    <dbReference type="eggNOG" id="KOG1121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009123_10_1_1"/>
    <dbReference type="InParanoid" id="Q2H2C0"/>
    <dbReference type="OMA" id="CECERVF"/>
    <dbReference type="OrthoDB" id="5245157at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="757"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="607"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="614"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ87457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="831" mass="95309" checksum="0C25A989889372B4" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2M5</accession>
    <name>Q2H2M5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CSC1/OSCA1-like 7TM region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_03971</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223185.1">
        <property type="nucleotide sequence ID" value="XM_001223184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2M5"/>
    <dbReference type="FunCoup" id="Q2H2M5">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="GeneID" id="4392060"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03971"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002458_2_1_1"/>
    <dbReference type="InParanoid" id="Q2H2M5"/>
    <dbReference type="OMA" id="DPTQVIW"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF26">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="536"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="584"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="611"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="676"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="15"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="189"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="395"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="774"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ87352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="874" mass="97038" checksum="5CEECE9A187A91EC" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2X2</accession>
    <name>Q2H2X2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_03874</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223088.1">
        <property type="nucleotide sequence ID" value="XM_001223087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2X2"/>
    <dbReference type="STRING" id="306901.Q2H2X2"/>
    <dbReference type="GeneID" id="4392013"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03874"/>
    <dbReference type="HOGENOM" id="CLU_1805959_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2X2"/>
    <dbReference type="OrthoDB" id="4589670at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ87255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="143" mass="15298" checksum="367C68764F694DE4" modified="2006-03-21" version="1">MVDEQPNNIQVIVGHCNVEGCSFAPRGSTIHLGPLPQKPSADLVMASLIPASNMLSSEGNLEGNQASGLALSSKIQALVHRLNHMKHGSKRPALSAANYVHIVEPQWNPSVEEQAIAGAVRMGQTRAVTIIRYVVKNSVEEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3Y5</accession>
    <name>Q2H3Y5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_06630</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Prevacuolar compartment membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222725.1">
        <property type="nucleotide sequence ID" value="XM_001222724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3Y5"/>
    <dbReference type="SMR" id="Q2H3Y5"/>
    <dbReference type="FunCoup" id="Q2H3Y5">
        <property type="interactions" value="397"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H3Y5"/>
    <dbReference type="GeneID" id="4390137"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06630"/>
    <dbReference type="eggNOG" id="KOG2527">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057172_2_1_1"/>
    <dbReference type="InParanoid" id="Q2H3Y5"/>
    <dbReference type="OMA" id="NMYTDYE"/>
    <dbReference type="OrthoDB" id="5227681at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034499">
        <property type="term" value="P:late endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07295">
        <property type="entry name" value="PX_Grd19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000030">
        <property type="entry name" value="Sorting nexin-3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042138">
        <property type="entry name" value="PX_Grd19_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051074">
        <property type="entry name" value="Sorting_Nexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963:SF2">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="21"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ90011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="142" mass="16642" checksum="7500A8A54BED4E0E" modified="2006-03-21" version="1">MQSLPDTRQQSFDEIYGPPENFLEIEVRNPRTHGIGRHMYTDYEIVCRTNIPAFKLRQSTVRRRYSDFEYFRDILERESARVTIPPLPGKVFTNRFSDDVIEGRRAGLEKFLKIVVGHPLLQTGSKVLAAFVQDPNWDRNAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H402</accession>
    <name>Q2H402_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_06613</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222708.1">
        <property type="nucleotide sequence ID" value="XM_001222707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H402"/>
    <dbReference type="FunCoup" id="Q2H402">
        <property type="interactions" value="675"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H402"/>
    <dbReference type="GeneID" id="4391124"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06613"/>
    <dbReference type="eggNOG" id="KOG1781">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_3_0_1"/>
    <dbReference type="InParanoid" id="Q2H402"/>
    <dbReference type="OMA" id="PFVQQEE"/>
    <dbReference type="OrthoDB" id="274944at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01729">
        <property type="entry name" value="LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000043">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017132">
        <property type="entry name" value="Lsm7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="50"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ89994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="139" mass="14608" checksum="93F031424BAA5052" modified="2006-03-21" version="1">MADRPHRGGHGGGSRGGRGGRGGGGRGGGGGGGQGQGQGQGQDKERPKKENILDLKKYMDKRITVKFNGGREATGVLKGYDALMNLVLDEVEELLRDDEGNEMTRPLGLVVVRGTLLVVLSPVDGSEVIANPFLQAEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H409</accession>
    <name>Q2H409_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222701.1">
        <property type="nucleotide sequence ID" value="XM_001222700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H409"/>
    <dbReference type="GeneID" id="4390819"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06606"/>
    <dbReference type="HOGENOM" id="CLU_3124904_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H409"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="50" mass="5568" checksum="26D0AE04FC3F6342" modified="2006-03-21" version="1">MSENLAASRDILHPKLSVESREQEWPGGAGHQSKVEGRVAEPSSFQKHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4G5</accession>
    <name>Q2H4G5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_06450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222545.1">
        <property type="nucleotide sequence ID" value="XM_001222544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4G5"/>
    <dbReference type="GeneID" id="4391152"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06450"/>
    <dbReference type="eggNOG" id="KOG2913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040201_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H4G5"/>
    <dbReference type="OrthoDB" id="407617at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="298" mass="32868" checksum="FA58B80F9D68F2B6" modified="2006-03-21" version="1">MDQLANKKDRRLAGFDDVSLGSMCVPIGPSKRRTCYLWPLSLTRFAGGLPFGVYAIAQNFNIPLQVQPQIFMALCLVSWAQILLYHRYGTFWGSHPRGQSLMLHDSNWPAWKASLLGLAVAIIFAGVEAALILTLKPIYDRGNEVPIMVVGIIAAVLLAAGLLPPYGELWKRRGRVIGINWGSFIDELTNAVTQNTFDVLGGVLYIVCCILEIGIFSSHLIWLARTRKIRKAAAAEGKTFDDVAAEHEMHGTPFKFAERKGQGLRLWGSGTSNKPSGKTQRIPTDSGEAQMQDVKRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5E7</accession>
    <name>Q2H5E7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Brl1/Brr6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_06118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222213.1">
        <property type="nucleotide sequence ID" value="XM_001222212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5E7"/>
    <dbReference type="STRING" id="306901.Q2H5E7"/>
    <dbReference type="GeneID" id="4390470"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06118"/>
    <dbReference type="eggNOG" id="KOG4503">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040960_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5E7"/>
    <dbReference type="OMA" id="HPHIPRI"/>
    <dbReference type="OrthoDB" id="5961at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040202">
        <property type="entry name" value="Brl1/Brr6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018767">
        <property type="entry name" value="Brl1/Brr6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136:SF1">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10104">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01042">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Brl1/Brr6" evidence="3">
        <location>
            <begin position="212"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ89499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="449" mass="49047" checksum="525B064650E7AF76" modified="2006-03-21" version="1">MSVSTFSSPTKQRSSNSNPFALAGTPKGSPLKPQDQPRPPHASFFNPQLPRKPSAPAFRNPAFTTPQKRVEELAYPDYSGAESSPALTDTSEMPAETPEFEREEEVGKLTLTPSAGRTLFSKTLLRNHASGRGEITRSSRDKIRKRKRLHGDRDVGSGRSRLPHDSDDSDSDWEDALGHGAKRSKDGKKPSRGWVNNFLSAVSDHPSAPAILSKWLQLGVNVILLSLVLFGMFAIFSQVRSDLSQAGEKARAAIVNEMSVCTENYRKNGCAPRSSRAPALDGPCNEWEACMNQDPSAIMHVQISAKNIAEIMNEFVGVLTFKTWGFILSLFLVAVVASNVGFGFLRESTLTHAPKPAEPLHSPPVVPPMLGSAVAHNPQQAYIWAPLSQTPRHVRKNFFANDVTDSEASPDMKMIMPPQTPSGRRSPSKGDRGRSPTKGTRVRSPSKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5H5</accession>
    <name>Q2H5H5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222185.1">
        <property type="nucleotide sequence ID" value="XM_001222184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5H5"/>
    <dbReference type="GeneID" id="4390947"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06090"/>
    <dbReference type="HOGENOM" id="CLU_3032190_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5H5"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="55" mass="6376" checksum="78613A345138152E" modified="2006-03-21" version="1">MTKSKSKDKKSDSKHKDKGKEKDRDDDRDRDNKDASSKGRDNEPRRYPYCISAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5T0</accession>
    <name>Q2H5T0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_05985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222080.1">
        <property type="nucleotide sequence ID" value="XM_001222079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5T0"/>
    <dbReference type="GeneID" id="4391045"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05985"/>
    <dbReference type="HOGENOM" id="CLU_2687600_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5T0"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="74" mass="7926" checksum="692B241F23AC788C" modified="2006-03-21" version="1">MPAFKVVICTIRPIAAIITFGNAIFAPQPGKLGNAVNQLHGAMRRHVAPIYARSCGFARTREYLAGGFANIVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6T5</accession>
    <name>Q2H6T5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trafficking protein particle complex subunit 6B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221725.1">
        <property type="nucleotide sequence ID" value="XM_001221724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6T5"/>
    <dbReference type="STRING" id="306901.Q2H6T5"/>
    <dbReference type="GeneID" id="4390084"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05630"/>
    <dbReference type="eggNOG" id="KOG3316">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076409_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H6T5"/>
    <dbReference type="OMA" id="CKEFWTA"/>
    <dbReference type="OrthoDB" id="941624at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="22988" checksum="D2D47E8760398DA4" modified="2006-03-21" version="1">MSFDPVMPPYNASDPTARFLSASCLDLLLIELVPMAYRLTNELELVARQQENEVAAAAAAAAAAAAEGVEGGEGGAAGRLSSGLGSGSGAVAGGGPGGTGAETETVMDEEEERGAVFWRLERIGYRVGQGLAERFSRDRPRFNDTLDVIKFLCKDIWTLVFRKQVDNLKTNHRFLWFPCGIVRGALAGLGITATVHAETTQMPTAIFQIKTVPAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6X8</accession>
    <name>Q2H6X8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_05587</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221682.1">
        <property type="nucleotide sequence ID" value="XM_001221681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6X8"/>
    <dbReference type="STRING" id="306901.Q2H6X8"/>
    <dbReference type="GeneID" id="4390542"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05587"/>
    <dbReference type="eggNOG" id="KOG0663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="Q2H6X8"/>
    <dbReference type="OMA" id="WVARATN"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07843">
        <property type="entry name" value="STKc_CDC2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000124">
        <property type="entry name" value="Cyclin-dependent kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000211">
        <property type="entry name" value="Cyclin-dependent kinase G-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045267">
        <property type="entry name" value="CDK11/PITSLRE_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="110"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="25"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="408"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ88968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="474" mass="52527" checksum="B4D7287791DB65A5" modified="2006-03-21" version="1">MSSKTKSRWADDEADAALEAQLKKEKEEKKRLKAAKARKLEAEKQAREAAAAAAQQEGDSTNGPPAKRRRISPEREAAQATGQSNESNDAPKLLRFYGGAFGRSRSVENYNKLNDIEEGAYGWVSRAKEVATGKVVALKRLKIDPRDRGGLPITGLREIQILKDCDHRNVVKLQEVVVGDDTSKIENIFLVLEFLEHDLKSILEDMPEPFLASEVKTLLQQLASGVAYLHDNWILHRDLKTSNLLLNNRGQLKIADFGMARYVGDPAPKLTQLVVTLWYRAPELLLGAARYGGAVDMWSVGCIFGELLTREPLLQGRNEVDELAKIFELCGTPTDDTWPGFRRLPNARALRLPSATTMTNGRAVGSAIRAKFPLLTAAGVGLLNGLLALDPDRRPTAKEMLAHEYFGQDPKPKQEAMFPTFPSKAGQERRRRRETPNAPIRGQQAADFGAVDFSGIFSGREREERGGGFSLRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7B6</accession>
    <name>Q2H7B6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221544.1">
        <property type="nucleotide sequence ID" value="XM_001221543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7B6"/>
    <dbReference type="GeneID" id="4391181"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05449"/>
    <dbReference type="HOGENOM" id="CLU_545115_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7B6"/>
    <dbReference type="OrthoDB" id="5571888at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="57"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="500" mass="57011" checksum="9DF1C1EC21AA1690" modified="2006-03-21" version="1">MAEDLTPHRTIPNDYNSYHPLRSEHHEIRLLRVLPGGDDDELAVVLVRSNRSNHPEYRALSYCWGSLNELAPVTVVFEDDRDVDSSSILDVDEPCGVLGPRAVTFQITTNLHDALASFRRTREHGYLWIDMLCINQGDVESGRGSWPIGNWPGESWPGESWQDSFLGKERLRRFYDFLSNPRLHVSVEDAPPGFDHALHTYRSRIATSSSEVWDWSTTVLTRGKWMVAALPRDMFRRMAVIAKAPWFRRVWVIQEVAAANRVRVRVADAEGSWEIIRSLRNFVSELFARIVAEEPTALASLDFGGHDLIPALWQDLVTWQDANTMTIVKLVEALRTFFATDPRDLDAGRETYARFTSSVIRSTGHLDILSMAKFYTRPERPAGLPGWTPDFSYRPPKDWDPMYNRGRWDQPFGRTLARMKDTNSWKTLQVAGIYEARVATIIDAQVVVDSRDGKGLDSKKLRDVPLQSLWACVNEAYAKTFLARGRNDHQPARPSSLTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H818</accession>
    <name>Q2H818_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </feature>
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        <location>
            <begin position="662"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
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    </evidence>
    <sequence length="711" mass="78170" checksum="90DABF22E84B1AB8" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H857</accession>
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        <dbReference type="NCBI Taxonomy" id="306901"/>
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <location>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ91662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="382" mass="43002" checksum="3979464453A0FBF5" modified="2006-03-21" version="1">MPYSDASYNYYSGPSEVLTDDSRKCQVEGCNKKHAFSRPDGDKKVYSKYCSNHTCEKTYPGEVDYHCKNPRSSNERYCSLHLTCGEPGCKKMGEHYGVREHVRWFCASHRCTSSECRLRATDRTQQRCTAHIILCNVPNCTRPAHQHRDGRLDATCAAHYGTQLCEWAAGCTRRASAGRSSSPSTSSSSKSPQYCASHQCRTPLCERPRAISRSSPSPSSRDILDHCELHTCRTSGCRGEVHTLVDYCARHACAGVGCGRGGRGADPATAAGSLLAVGLDRDLCAVHAQAGQRRAVSLNAGEIGLDWDELRGRFEMGEGGRRERERKRLSDDLERMRRRERELEEDLERAERRRGLDREAMDRLQRDFQAWNGVSEWDSRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9W4</accession>
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    </protein>
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        <name evidence="6" type="ORF">CHGG_02990</name>
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    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
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        <lineage>
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    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="476" last="476">
            <title>High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Ruppert T."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="35079002"/>
            <dbReference type="DOI" id="10.1038/s41467-022-27967-9"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS)</scope>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e57984" last="e57984">
            <title>Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.</title>
            <authorList>
                <person name="Thoms M."/>
                <person name="Lau B."/>
                <person name="Cheng J."/>
                <person name="Fromm L."/>
                <person name="Denk T."/>
                <person name="Kellner N."/>
                <person name="Flemming D."/>
                <person name="Fischer P."/>
                <person name="Falquet L."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="37921038"/>
            <dbReference type="DOI" id="10.15252/embr.202357984"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.91 ANGSTROMS)</scope>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2024" name="Nat. Commun." volume="15" first="716" last="716">
            <title>Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.</title>
            <authorList>
                <person name="Klein M.A."/>
                <person name="Wild K."/>
                <person name="Kisonaite M."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="38267453"/>
            <dbReference type="DOI" id="10.1038/s41467-024-44862-7"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL29 family.</text>
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        <property type="protein sequence ID" value="EAQ91055.1"/>
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    </dbReference>
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        <property type="resolution" value="2.94 A"/>
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        <property type="method" value="EM"/>
        <property type="resolution" value="2.91 A"/>
        <property type="chains" value="Lb=1-65"/>
    </dbReference>
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    <dbReference type="EMDB" id="EMD-17957"/>
    <dbReference type="SMR" id="Q2H9W4"/>
    <dbReference type="FunCoup" id="Q2H9W4">
        <property type="interactions" value="482"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H9W4"/>
    <dbReference type="GeneID" id="4388903"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02990"/>
    <dbReference type="eggNOG" id="KOG3504">
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    <dbReference type="OMA" id="PRTNKYP"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002673">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01779">
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        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="47"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
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        </location>
    </feature>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PDB" id="7OLC"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PDB" id="7OLD"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="8OO0"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="8PV6"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="8PV8"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HA25</accession>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
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    <dbReference type="RefSeq" id="XP_001229445.1">
        <property type="nucleotide sequence ID" value="XM_001229444.1"/>
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    <dbReference type="STRING" id="306901.Q2HA25"/>
    <dbReference type="GeneID" id="4388404"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02929"/>
    <dbReference type="eggNOG" id="ENOG502S0P1">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046457_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HA25"/>
    <dbReference type="OMA" id="QWEYAHE"/>
    <dbReference type="OrthoDB" id="3981028at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="453" mass="49465" checksum="F37511F90CB18E30" modified="2006-03-21" version="1">MATNHTSYMAAESLAQARGLSSSISSLSASNTSGRNNAASHISKTYRQASTLFLTRRLPEALSTVLPLVSPPQSDDPNNESTEPAPVIRASRSSRVKVWSLYLTVLNAIAELDPEDGKDAFGGQDWRALCYKVRSGDIWEEVIRNGYHGVEADVDAEVVINLATLLLAHSKTQNLNQKRLENYLAAARTPSLDISADRFSESPARRHESPSPSPAASRKTRRPAPSGADTPRDLNARVKILELYTLHVLPRNDQWEYAHEFISVSPVLDDERREAFLQALDTLREEQAEAGRREEEERAAREEAIRRDIEEARRLRAENEAREKKRLEEERLKRDAEAREREREKEREKERLETAKAKAKAKATVDDFGVESNASSSSSTPAAPASPALKKGGSSGSQASGSGGMARSRGPLPRRGAGNAGGGGGSNAVAAPTLMSRASMVWSAHAAQPEEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAD6</accession>
    <name>Q2HAD6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_02818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229334.1">
        <property type="nucleotide sequence ID" value="XM_001229333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAD6"/>
    <dbReference type="STRING" id="306901.Q2HAD6"/>
    <dbReference type="GeneID" id="4388622"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02818"/>
    <dbReference type="eggNOG" id="ENOG502S7U4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_969775_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HAD6"/>
    <dbReference type="OrthoDB" id="5395975at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ90883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="287" mass="31222" checksum="F2C25B6AC7A0A642" modified="2006-03-21" version="1">MATNNPKRHTRTWALSSPDPPGENRNAADHHQHQQHQGSWKSRDWSPPTQVEPSSAPRPSFVAESEPPLPQRGPEHRPKTPSPDKPLTRRSGHIGPPTTTTTANNNPTPTPTTPPFPASPSLPLTTPLTLHSPPPPTSDTPLHPEDLITDVLARLASSLNLAQRFQPTSQTRPLRPFERGYWLVDCRGWDAALKRSAWGFLASYLAKGAAGWGTSCTRDAGFAWLRVYCWGGVVGHMYLVLYLMSRRRVLETGAEWVGAEGTAVVVVAARAAKAPAAEGRWEVGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAN3</accession>
    <name>Q2HAN3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_02721</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229237.1">
        <property type="nucleotide sequence ID" value="XM_001229236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAN3"/>
    <dbReference type="GeneID" id="4389424"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02721"/>
    <dbReference type="eggNOG" id="ENOG502S6I1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_377654_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HAN3"/>
    <dbReference type="OrthoDB" id="2150604at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="entry name" value="Ribosomal protein L9, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_bL9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_bL9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein L9" evidence="4">
        <location>
            <begin position="480"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ90786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="734" mass="80740" checksum="DF39596634D9E921" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBP0</accession>
    <name>Q2HBP0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_02364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228880.1">
        <property type="nucleotide sequence ID" value="XM_001228879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBP0"/>
    <dbReference type="GeneID" id="4389527"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02364"/>
    <dbReference type="eggNOG" id="ENOG502SX08">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038480_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HBP0"/>
    <dbReference type="OMA" id="WAWETSE"/>
    <dbReference type="OrthoDB" id="1430630at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="419"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="507"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="508"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ90429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="60813" checksum="DEA91B614FD7C728" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCF3</accession>
    <name>Q2HCF3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221322.1">
        <property type="nucleotide sequence ID" value="XM_001221321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCF3"/>
    <dbReference type="STRING" id="306901.Q2HCF3"/>
    <dbReference type="GeneID" id="4386935"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02101"/>
    <dbReference type="eggNOG" id="ENOG502S3UT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052209_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HCF3"/>
    <dbReference type="OMA" id="MDIDYPY"/>
    <dbReference type="OrthoDB" id="5316527at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="294" mass="32643" checksum="7EF835E72AD92BB3" modified="2006-03-21" version="1">MGPEWQAFVNLANDPHVAQLVLDSASRNAVFTSRLGKATKITRYWMDIDYPYAAPPVYERTGILVTDDAMSLVTVPYDSWVAKQMQRVLWPKPMALGFWALGTAAVKQTSFEVAKYFGFGSEEPGRAQPPNPATPPPLPSGPGPEMQKALQQIRQQSTRRPEEVNDPGSMSSSANAPSAASSTPRDKPMPMPEKPTLGQNNQDTPVQKTWLQEMVLSVATSQPWKQLKQTYSKEQRPFRADPPRGCVCVSGLVELETPKAFVLLDVMTWYDPKTNSRAPGTTAIYFRKIRSKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCJ0</accession>
    <name>Q2HCJ0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_02064</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221285.1">
        <property type="nucleotide sequence ID" value="XM_001221284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCJ0"/>
    <dbReference type="FunCoup" id="Q2HCJ0">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="GeneID" id="4387360"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02064"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="InParanoid" id="Q2HCJ0"/>
    <dbReference type="OMA" id="LFMGLNM"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF155">
        <property type="entry name" value="EFFLUX PUMP AFOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="53"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ93829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="558" mass="59649" checksum="85B979EA8F9CCA72" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDS7</accession>
    <name>Q2HDS7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220848.1">
        <property type="nucleotide sequence ID" value="XM_001220847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDS7"/>
    <dbReference type="GeneID" id="4387073"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01627"/>
    <dbReference type="eggNOG" id="ENOG502RJBV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1397202_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HDS7"/>
    <dbReference type="OMA" id="RNCVCAR"/>
    <dbReference type="OrthoDB" id="4588525at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="194" mass="22233" checksum="064A298A9E43DC50" modified="2006-03-21" version="1">MCLIGLLLPLKPKKQTRTHRSKGSSHRHSSHGHSGHRRSERPHRERSHRREKEEPRNSAAVAEDALARLCLSLEQSLLDEQQRWREQDRLDTSERRRLGLERDRTPFEEAPPYSVRDTMRQPTPEPQSQNGIADRPRSRERESDSTGSAHCCRNCVCARCGHGSVKCPTTPELDDTARVRAFTNDGADSRRRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDZ8</accession>
    <name>Q2HDZ8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_01556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220777.1">
        <property type="nucleotide sequence ID" value="XM_001220776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDZ8"/>
    <dbReference type="STRING" id="306901.Q2HDZ8"/>
    <dbReference type="GeneID" id="4387556"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01556"/>
    <dbReference type="eggNOG" id="ENOG502SCYV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072332_0_2_1"/>
    <dbReference type="InParanoid" id="Q2HDZ8"/>
    <dbReference type="OrthoDB" id="4089664at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ93321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="223" mass="25509" checksum="542517F4FAA5C866" modified="2006-03-21" version="1">MRGDHSYSSYPYLADQEFVEVCHHFDRQYRQADLGETRRRWRVDVISAVEPAIVFSFGPERYTWLQITRPLENPDDGDLSSYLDGFSFNEHRTNREMDLDLNERDSEMLSTEEADQAVIVKQLPAQRIPVGQHGHVGTSHIHRTYDAGCGQLIRLPADEDPLSIDTVFRRLVPDHFKAGMRASTGTLDGISLGVGPFFLSFGPEFLGDARYWWLTEILFDGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HE47</accession>
    <name>Q2HE47_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
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            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="114" mass="12452" checksum="E507ACF64F625DBF" modified="2006-03-21" version="1">MPRRHATLELDSSRLPRQVAVIVEDRVIYSRQDAGWQTLASATWKLFQVASSIPPEPPPCAAGHQLSRCQVERHGTLTEAPRSPSKLGPDLGDPLLNKTRKATSCTQPNATGTK</sequence>
</entry>
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        </source>
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    <dbReference type="Pfam" id="PF10551">
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            <end position="121"/>
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        <location>
            <begin position="735"/>
            <end position="761"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ93217.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
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    </evidence>
    <sequence length="898" mass="98990" checksum="39F248A6646A1AE6" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEG9</accession>
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                <person name="Untereiner W.A."/>
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            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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        <location>
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            <end position="17"/>
        </location>
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            <end position="1770"/>
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            <end position="215"/>
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    </feature>
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            <end position="65"/>
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    </feature>
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        <location>
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            <end position="1395"/>
        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
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            <end position="427"/>
        </location>
    </feature>
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    </feature>
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        <location>
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        <location>
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            <end position="1365"/>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ93150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1770" mass="195949" checksum="1317566F06D41D04" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEP8</accession>
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        <recommendedName>
            <fullName evidence="13">Isotrichodermin C-15 hydroxylase</fullName>
        </recommendedName>
    </protein>
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    <organism evidence="11 12">
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
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    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220527.1">
        <property type="nucleotide sequence ID" value="XM_001220526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEP8"/>
    <dbReference type="STRING" id="306901.Q2HEP8"/>
    <dbReference type="GeneID" id="4388332"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01306"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="InParanoid" id="Q2HEP8"/>
    <dbReference type="OMA" id="KNIAGHY"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF230">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ93071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="46673" checksum="1752DDD4F944742F" modified="2006-03-21" version="1">MINTQHLIIEATSNPTLLIGSVAILLLTYPFLTLTYNLLLHPLRHIPGPLLDRASPLPWAIRHALGTSAFHTERLHVRYGAVVRIAPNHLSFTSPRAWRDIYGSLPRDGSYTSVWPEVSKSKTFTSATDDQEESVIQAGFHEHARLRRALAPGFTDAALRVQERVFRGYVERLVGKIGEKCGGGGGGGEKGAVMDVEKWYNWTTFDIAGELVFGSAFGCLEKEEYHPMDCVPDGHADGGGGDGVDYLSWGKVVEHLLRKVFSNGLVLTLGGSETIATTLCGATYLLLDNPETMKRLSQEVRGSFNNADEITVKALSQLPYLTAAINETLRMYPPVTSDLIRVIPPEGKNIAGHYVTGGTYVEIQQWSINHSPDNWVDPWTFNPDRFLLEDDKAREAGNILEASQPFSWGPRNCLGRKNGVGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HF83</accession>
    <name>Q2HF83_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220342.1">
        <property type="nucleotide sequence ID" value="XM_001220341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HF83"/>
    <dbReference type="STRING" id="306901.Q2HF83"/>
    <dbReference type="GeneID" id="4388327"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01121"/>
    <dbReference type="eggNOG" id="ENOG502S130">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_25_3_1"/>
    <dbReference type="InParanoid" id="Q2HF83"/>
    <dbReference type="OrthoDB" id="4842715at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="43344" checksum="D84752B5C5C98DFB" modified="2006-03-21" version="1">MSPQPDSSPFRDSRTRTINNMRKTTRTPGVQEIVYGESTVRDVPRAEVHPASGHAKVNLANPGGGTSPVKPEGSAGFLGVWLDWKLNWKAHLVAVEKKPRTQSYALSRIVAKTWGMGLAKAREVYTKCIRSALAYGASSFHIPTDVGGEPVKKGITKALGKAQNKSLRIVAGAFKSTPIRNLETETWVPPLDLYLNKRLADYENRLQRPDLDDGQGGKKTAASVVLTACRKIQQRLSSRRGNRGRPRTLGPQGPMAVERAAGTETLFRNGTLRRHDGLSKAKSSLLIQIRTGAIGLRDFLFTRGVPEVLTPACECGEGRETAEHLVVWCLAPPLTRRWERTGIRTRRDFYSVLHGINPTTARLARRVLDWLMDSAKLPMYNLARRLELEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFB3</accession>
    <name>Q2HFB3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220312.1">
        <property type="nucleotide sequence ID" value="XM_001220311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFB3"/>
    <dbReference type="STRING" id="306901.Q2HFB3"/>
    <dbReference type="GeneID" id="4386597"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01091"/>
    <dbReference type="eggNOG" id="ENOG502RJMB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_435592_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HFB3"/>
    <dbReference type="OMA" id="YNDAIPE"/>
    <dbReference type="OrthoDB" id="3438093at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026736">
        <property type="entry name" value="Virilizer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23185">
        <property type="entry name" value="PROTEIN VIRILIZER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23185:SF0">
        <property type="entry name" value="PROTEIN VIRILIZER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="645"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="667" mass="72382" checksum="C418D506A0B2E6EA" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFQ2</accession>
    <name>Q2HFQ2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 15">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="5 15">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_00952</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="5 15"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220173.1">
        <property type="nucleotide sequence ID" value="XM_001220172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFQ2"/>
    <dbReference type="FunCoup" id="Q2HFQ2">
        <property type="interactions" value="713"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HFQ2"/>
    <dbReference type="GeneID" id="4387202"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00952"/>
    <dbReference type="eggNOG" id="KOG0190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025879_5_0_1"/>
    <dbReference type="InParanoid" id="Q2HFQ2"/>
    <dbReference type="OMA" id="FFGMKKD"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
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    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 15 18" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005142955" description="Protein disulfide-isomerase" evidence="15">
        <location>
            <begin position="21"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="17">
        <location>
            <begin position="7"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="17">
        <location>
            <begin position="335"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="470"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="488"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="50"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="385"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00002692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ92717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="503" mass="54855" checksum="2FD4E3CFE74E2370" modified="2006-03-21" version="1">MHKAHKFALGLLAAAAVATASDVVQLKKDTFDEFVKANDLVLAEFFAPWCGHCKALAPEYEEAATSLKEKDIKVVKVDCTEEADLCQQHGVEGYPTLKVFRGLDNVSPYKGQRKAAAITSYMVKQSLPAVSEVTKDTLEEFKKADKVVLVAYLDAADKASSEVFTAAAEKLRDNYPFGLSTDAALAEAEGVTAPAVVLYKDFDEGKSVFSEKFDAEEIEKFAKTAATPLIGEVGPETYSDYMSAGLPLAYIFAETAEERKEISELLKPIAEAQRGVVNFGTIDAKSFGAHAGNLNLKTDKFPAFAIQEVAKNQKFPFDQEKEITFDAIKAFVDDFVAGKVEPSIKSEPIPETQEGPVTVVVAKNYNDIVLDDTKDVLIEFYAPWCGHCKSLAPKYEELAALYGKSEFKDQVVIAKVDATANDVPDEIQGFPTIKLYPAGNKAEAVTYSGSRTVEDLIKFIAENGKYKASVSEEVEEPSSAETEAASETETKAEEAKETEHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFQ3</accession>
    <name>Q2HFQ3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220172.1">
        <property type="nucleotide sequence ID" value="XM_001220171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFQ3"/>
    <dbReference type="STRING" id="306901.Q2HFQ3"/>
    <dbReference type="GeneID" id="4387540"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00951"/>
    <dbReference type="eggNOG" id="ENOG502RJYD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_773863_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HFQ3"/>
    <dbReference type="OrthoDB" id="4585112at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="358" mass="39258" checksum="047DED1955DB2C89" modified="2006-03-21" version="1">MSETVSVEEYDGIYSQSQSRPSNQGTRSGSPTISMEERAEQLSPIEHVFRGYSTSEETLDGLGDEPVPGPPPATPTSLSKTRQIRLSDLFEPSVLGSGVAPEVIEIDTKGKINETTTELVTKQLSRREAGPGVPSVESSSPLIPLSASRLPEGWVRRSWELADEAERPNSRERKLKLKVSRGALSKSRRQTGGTSGASFDSHRLSSELSRSDDASPNNVEGLEGLERHSFITNTPPAPPPSQCCGEFANQASRTTQKPAVPNEILTLLSSRSRVNGKALRRLQKRFPDLESRLGELHLQMLEHSTTTHASEGGRAVGVADANPVRKRRHGRLRGRVARWMSKARQAITRSRSRPRSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGA9</accession>
    <name>Q2HGA9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="3">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_00745</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="3"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219966.1">
        <property type="nucleotide sequence ID" value="XM_001219965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGA9"/>
    <dbReference type="GeneID" id="4386950"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00745"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001248_0_2_1"/>
    <dbReference type="InParanoid" id="Q2HGA9"/>
    <dbReference type="OMA" id="INTHCKI"/>
    <dbReference type="OrthoDB" id="5095382at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="52"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="503"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="505"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ92510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1103" mass="122713" checksum="58F4ED5071CCA521" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGC9</accession>
    <name>Q2HGC9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endonuclease III homolog</fullName>
            <ecNumber evidence="8">3.2.2.-</ecNumber>
            <ecNumber evidence="8">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="8">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NTH1</name>
        <name evidence="12" type="ORF">CHGG_00725</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="8"/>
    <dbReference type="EC" id="4.2.99.18" evidence="8"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219946.1">
        <property type="nucleotide sequence ID" value="XM_001219945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGC9"/>
    <dbReference type="STRING" id="306901.Q2HGC9"/>
    <dbReference type="ESTHER" id="chagb-q2hgc9">
        <property type="family name" value="Duf_676"/>
    </dbReference>
    <dbReference type="GeneID" id="4386803"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00725"/>
    <dbReference type="eggNOG" id="KOG1921">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_304196_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGC9"/>
    <dbReference type="OrthoDB" id="273452at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000003">
        <property type="entry name" value="Endonuclease III homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="HhH-GPD" evidence="11">
        <location>
            <begin position="612"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="343"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="474"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="887"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="936"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="474"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="527"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="557"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="894"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="905"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="915"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ92490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="977" mass="107481" checksum="52064B2AF2192B17" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGD1</accession>
    <name>Q2HGD1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219944.1">
        <property type="nucleotide sequence ID" value="XM_001219943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGD1"/>
    <dbReference type="GeneID" id="4386764"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00723"/>
    <dbReference type="HOGENOM" id="CLU_933833_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGD1"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="298" mass="32362" checksum="FB77F329C13F08C5" modified="2006-03-21" version="1">MTSWRFSAIKAACYAVISARPVVPETDQPTKDKGHDGPQLPASATWDNRSPKLHIELAARLPNDGAQKRGGNSSRGRCDAKRLPPLLSTVSGRHNQVSQSPAAYVPNPAKTARRERRQTCMKAQNHPKRMRAMPKPSFKVVIQPSRNLFKPKPKISPHHRHRNIALAGVAAPRRTLPPDLTAYRGRVMGGHTGLSPPCSSLSTRARGGGSAAALRLGYCERPLQGGGDDPSSKVLQPARGREHVAVAEPSRKPGASMGPTSSGRRQPTNYEREQNPSRPPGSDRCRSHLSESAHQDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGF9</accession>
    <name>Q2HGF9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 11">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_00695</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 11"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219916.1">
        <property type="nucleotide sequence ID" value="XM_001219915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGF9"/>
    <dbReference type="FunCoup" id="Q2HGF9">
        <property type="interactions" value="343"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HGF9"/>
    <dbReference type="GeneID" id="4386920"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00695"/>
    <dbReference type="eggNOG" id="KOG3754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010467_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGF9"/>
    <dbReference type="OMA" id="IAHMFIR"/>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000001">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000004">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208934" description="Glutamate--cysteine ligase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="523"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="523"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ92460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="694" mass="77566" checksum="A9C8C93EA5C7EA77" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGH1</accession>
    <name>Q2HGH1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CHGG_00683</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219904.1">
        <property type="nucleotide sequence ID" value="XM_001219903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGH1"/>
    <dbReference type="SMR" id="Q2HGH1"/>
    <dbReference type="STRING" id="306901.Q2HGH1"/>
    <dbReference type="GeneID" id="4386839"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00683"/>
    <dbReference type="eggNOG" id="ENOG502RAK7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031730_0_2_1"/>
    <dbReference type="InParanoid" id="Q2HGH1"/>
    <dbReference type="OMA" id="SGLQWFK"/>
    <dbReference type="OrthoDB" id="2525337at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF13">
        <property type="entry name" value="ENDOGLUCANASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209164" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="17">
        <location>
            <begin position="18"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="18">
        <location>
            <begin position="18"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAQ92448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="246" mass="25848" checksum="727CD33A1BB38E29" modified="2006-03-21" version="1">MKLSLVSLLGAALSVEGHAIFQKVSVNGADQGSLTGLRAPNNNNPVQDVSSQNMICGQPGSTSQTVIQVKAGDRIGAWYQHVIGGAQFPNDPDNPIASSHKGPVMAYLAKVDNAASASLNGLKWFKIWEDTFDTGSRVWGVDNLLKNNGWVYFNLPQCVASGQYLLRVEVLALHSAGKQGQAQFYQSCAQINVSGSGSLSPSDTVSFPGAYSASDPGILTSIYGSTGKPDNDGKAYTAPGPRPISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH39</accession>
    <name>Q2HH39_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SQS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_00465</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SQS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219686.1">
        <property type="nucleotide sequence ID" value="XM_001219685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH39"/>
    <dbReference type="STRING" id="306901.Q2HH39"/>
    <dbReference type="GeneID" id="4387938"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00465"/>
    <dbReference type="eggNOG" id="KOG0154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007254_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HH39"/>
    <dbReference type="OMA" id="QTSQHDH"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02646">
        <property type="entry name" value="R3H_G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034082">
        <property type="entry name" value="R3H_G-patch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051189">
        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="11">
        <location>
            <begin position="526"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="10">
        <location>
            <begin position="660"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="247"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ92230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="703" mass="77188" checksum="B089A2AA72C5BE91" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHI3</accession>
    <name>Q2HHI3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219542.1">
        <property type="nucleotide sequence ID" value="XM_001219541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHI3"/>
    <dbReference type="GeneID" id="4388208"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00321"/>
    <dbReference type="eggNOG" id="ENOG502RZ22">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_891377_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHI3"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054464">
        <property type="entry name" value="ULD_fung"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22893">
        <property type="entry name" value="ULD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="174"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ92086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="312" mass="34578" checksum="498881648246E74B" modified="2006-03-21" version="1">MILYIMTLAAQTRMLAGRFPSPSGTPFDGDDQDQEAEKDLLRQQAENLFQVSYQSLRDVMDGAGNHVESFETDQTDEVFEDPDKTQSTQLQLWKEASERDNTTHWLYELVFLSYVESRSGLPTTAKSSDDEAEAEGVVQIDGFPNEERALLAGNPPEVAGVGEKRPSGSKGTEVPTIKFKDAVGRRFSFPYHLVQTWAGTEKLIKEAFLHVEDIGPQVQDGRYDIIGPSGDIILPSVWEHVIQPGDAFTMHMWPRDKVQLQGAPQHTPKLVLSVQKQSGPSPGGVGTVLGAHGSRRHSHVEFDKTSQQHPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI12</accession>
    <name>Q2HI12_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219363.1">
        <property type="nucleotide sequence ID" value="XM_001219362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HI12"/>
    <dbReference type="STRING" id="306901.Q2HI12"/>
    <dbReference type="GeneID" id="4387871"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00142"/>
    <dbReference type="eggNOG" id="ENOG502S791">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1209693_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HI12"/>
    <dbReference type="OrthoDB" id="2148716at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="2">
        <location>
            <begin position="11"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="229" mass="25030" checksum="48A28D1BD82C97EE" modified="2006-03-21" version="1">MSDMYPQYLPSLSERDAIADALYRVAIGCDRNDVQLFNSGWAGEDVSFKIHRDDETVMSSLAVIRENILDIVGPMDTTHNVTMVRVNLRDGADTATMTAMSTAYHSSAGMGRDPTGPEYIAGGEYLANLIKDGSGVWRIKKLCRPQCDAHLPPATSASSRYKTRRLSLAREIHAVVRTSNDFRRGLRSPQRAGEPYGARGAEGGNRGAGEESGVGDKRRARRQGSARIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI47</accession>
    <name>Q2HI47_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219328.1">
        <property type="nucleotide sequence ID" value="XM_001219327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HI47"/>
    <dbReference type="STRING" id="306901.Q2HI47"/>
    <dbReference type="GeneID" id="4387907"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00107"/>
    <dbReference type="eggNOG" id="KOG1437">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067857_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HI47"/>
    <dbReference type="OMA" id="YATNNTQ"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209200" description="FAS1 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="186"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="351" mass="36774" checksum="855BFE0D8247D789" modified="2006-03-21" version="1">MLGQHVISVVAIFAALTSGQTLVSVLEDNGFSEYAALIQGDPSIEAASDLIVYAPTDAALVANNETLNRRVTAEGRKNIRASLACVRRSAFRPRPPPKRAQTWGNSTRPVRYRKEVPSGSAFMSLLSDPEFVNLGPGVNQSIVEKHPGSSELPVVFSGLGETIKVTGNDIAFDRGVIRPTDGLPTLPETASKTLPFLGVSTFFDALNQTGVLAELDTRRGPITILAPDDNAFKGKAFTHDQLTALVRRHVLVDYFAYTPLLEDHQVYPTLGGGEVVVAVNNKGAASLGGAGILAGDAIITNGVVHTIDKIIDAAGSPPPLVTGGANSMTGQSWKALVASAVGVVLAAGFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GLX6</accession>
    <name>Q2GLX6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_11080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408038">
        <property type="protein sequence ID" value="EAQ82904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230256.1">
        <property type="nucleotide sequence ID" value="XM_001230255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GLX6"/>
    <dbReference type="GeneID" id="4397395"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_11080"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GLX6"/>
    <dbReference type="OMA" id="QWMATIT"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208362" description="Peptidase A1 domain-containing protein" evidence="4">
        <location>
            <begin position="17"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="67"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ82904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="339" mass="36604" checksum="AA19A7AC436B4385" modified="2006-03-21" version="1">MKMLLWIALQLGPAWGAALPETKPSLDPIPQHMSPFQLGGHTKPEDYGRPVNIDLEVWTRGQTQLQWYGEITVDTPPQKFKLIFDTGASLMLIAHKNCTTCGNHPLYDPTASQTFSAQPGYKLEVTFGSQGGGTTSTPEVQGANCTVVTDTVRMGGRGPPASEFLICDNYSSGLRDQPPDGIFGLGSTPYALPAPEFSFSFARVPRRAGVLTLGGTDRSQYVPGTLRTIPLNWPLSESRWRWVVDVRGARVGDGPMLANSTDAVTLVDTGGATIITPDREMTAELYGRMSSEIRPLDERGAWGAPCGVLDRAARDVLGQRKCLKRIEVVAAKAAAAETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMI2</accession>
    <name>Q2GMI2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription activator GCR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_10822</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226089.1">
        <property type="nucleotide sequence ID" value="XM_001226088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMI2"/>
    <dbReference type="GeneID" id="4397181"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10822"/>
    <dbReference type="HOGENOM" id="CLU_009209_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GMI2"/>
    <dbReference type="OMA" id="HARPRAY"/>
    <dbReference type="OrthoDB" id="5103085at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060963">
        <property type="term" value="P:positive regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.20">
        <property type="entry name" value="Centromere DNA-binding protein complex CBF3 subunit, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052146">
        <property type="entry name" value="HOT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038279">
        <property type="entry name" value="Ndc10_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031872">
        <property type="entry name" value="NDC10_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022210">
        <property type="entry name" value="TF_GCR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37784:SF2">
        <property type="entry name" value="HIGH-OSMOLARITY-INDUCED TRANSCRIPTION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37784">
        <property type="entry name" value="PROTEIN MSN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12550">
        <property type="entry name" value="GCR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16787">
        <property type="entry name" value="NDC10_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ndc10" evidence="3">
        <location>
            <begin position="366"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription activator GCR1-like" evidence="2">
        <location>
            <begin position="684"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ83004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="782" mass="87294" checksum="1936E34FDC327536" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMP0</accession>
    <name>Q2GMP0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ82946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226031.1">
        <property type="nucleotide sequence ID" value="XM_001226030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMP0"/>
    <dbReference type="STRING" id="306901.Q2GMP0"/>
    <dbReference type="GeneID" id="4397256"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10764"/>
    <dbReference type="eggNOG" id="ENOG502S62N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_8_3_1"/>
    <dbReference type="InParanoid" id="Q2GMP0"/>
    <dbReference type="OMA" id="HESHMSA"/>
    <dbReference type="OrthoDB" id="5231586at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="107"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ82946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="220" mass="25339" checksum="4BDA606C8581CBE1" modified="2006-03-21" version="1">MANLLLAQRDGGRVGKHWAEKFVKRQPKLKTRFNRAYDFQRALCEDPELTGAWFKLVHNMRAKYGIHDCDFYNFDETGFMMGVICASMVVTRADRRGRGKAVQPGNREWATAIECINGEGWCLPPFLIVQGMYRLANWYTESNLPLDWAIKPTSNGWTDNETGVEWIKHFDKHTKSRTKGEYRLILLDAHESHMSAKFEAFCKQNNIVTISLPAHSSHIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNA2</accession>
    <name>Q2GNA2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit</fullName>
            <ecNumber evidence="3">2.4.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GlcNAc-PI synthesis protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_10552</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.198" evidence="3"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228479.1">
        <property type="nucleotide sequence ID" value="XM_001228478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNA2"/>
    <dbReference type="FunCoup" id="Q2GNA2">
        <property type="interactions" value="411"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GNA2"/>
    <dbReference type="GeneID" id="4396407"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10552"/>
    <dbReference type="eggNOG" id="KOG1111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_19_2_1"/>
    <dbReference type="InParanoid" id="Q2GNA2"/>
    <dbReference type="OMA" id="SHFWMSG"/>
    <dbReference type="OrthoDB" id="734129at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03796">
        <property type="entry name" value="GT4_PIG-A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000053">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000026">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039507">
        <property type="entry name" value="PIG-A/GPI3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="10">
        <location>
            <begin position="44"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="9">
        <location>
            <begin position="214"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ84148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="486" mass="54383" checksum="6ACFA325C897D5CA" modified="2006-03-21" version="1">MAPTYNIAMVSDFFFPQPGGVESHIYQLSSKLRDRGHKVIIITHAYKGRTGVRYLTNGLKVYHVPFFVLYRSASFPTVFSFFPIFRNIILRERIDIVHGHASLSSLCHEAILHARTMGLRTVYTDHSLFGFADAASIFANKLLKFSLSDVDHVICVSHTCKENTVLRASLDPLMVSVIPNAVVAENFRPLDYTEPSPRSFAPHHPPPARPLGPHDMITIVVISRLFYNKGTDLLTAAIPRILHNHPHTRFIIAGDGPKAIDLEQMIEQNVLQDRVEMLGPIRHEEVRDVMVRGHIYLHPSLTEAFGTVIVEAASCGLYVVCTQVGGIPEVLPSHMTVFAKPEEDDLVTATGKAIAALRANKVRTELFHEQVKSMYSWTNVAMRAERVYNGISGAISEAEFYGYDAANGAGSWSATRGRSGVQSFALIDRLKRYYGCGTWAGKLFCLCVIVDYLIFLALELWFPRDRIDICPDWPRKERKVDGKDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNJ3</accession>
    <name>Q2GNJ3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228388.1">
        <property type="nucleotide sequence ID" value="XM_001228387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNJ3"/>
    <dbReference type="GeneID" id="4396664"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10461"/>
    <dbReference type="HOGENOM" id="CLU_1677670_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNJ3"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004207981" description="GPI anchored protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="15627" checksum="21B940872FF5FEC0" modified="2006-03-21" version="1">MQLQSSLLLTALLTSLAGAATTTTTTTTGDALASPTPDTSSTPTPPSDSDSANDTTQSVTRSISTIPSNFPSSLSSTLTVTGTRASSNATLTTSATRTATSPADDGDDDEEDRDRTRTRTSTRAPSTPTAINAAAAAGAPAVMGLGMGMALMAVVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNL1</accession>
    <name>Q2GNL1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_10443</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84039.1"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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            <end position="87"/>
        </location>
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        <location>
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        </location>
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        </location>
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        </location>
    </feature>
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            <begin position="656"/>
            <end position="679"/>
        </location>
    </feature>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ84039.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="703" mass="76453" checksum="E6D7E2B7DB18BF69" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNT7</accession>
    <name>Q2GNT7_CHAGB</name>
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        <recommendedName>
            <fullName evidence="6">IPT/TIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_10367</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1336"/>
            <end position="1355"/>
        </location>
    </feature>
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        <location>
            <begin position="732"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="934"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="967"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="550"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="1297"/>
        </location>
    </feature>
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        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
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            <end position="579"/>
        </location>
    </feature>
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        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="633"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
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            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="686"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1057"/>
            <end position="1072"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ83963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1400" mass="150433" checksum="CAE01B115A43FABD" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNU8</accession>
    <name>Q2GNU8_CHAGB</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228283.1">
        <property type="nucleotide sequence ID" value="XM_001228282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNU8"/>
    <dbReference type="GeneID" id="4396943"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10356"/>
    <dbReference type="HOGENOM" id="CLU_2049420_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNU8"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="120" mass="13113" checksum="B4245CF0D8D444ED" modified="2006-03-21" version="1">MVKIELAEHTQPPLTNTAVGARMSGETAFQGGTEPQHGTGGCWFCAVTQRPRYGSREYVDSMTSSGPTQSTGRRGGDGRAIRDRDSGKKPSDEPGDRLDRALSKRAGVRVSHCWLFYDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPN9</accession>
    <name>Q2GPN9_CHAGB</name>
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        <recommendedName>
            <fullName evidence="8">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_10065</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EAQ83661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227992.1">
        <property type="nucleotide sequence ID" value="XM_001227991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPN9"/>
    <dbReference type="STRING" id="306901.Q2GPN9"/>
    <dbReference type="GeneID" id="4396585"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10065"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPN9"/>
    <dbReference type="OMA" id="SHAGKCH"/>
    <dbReference type="OrthoDB" id="4564677at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF185">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="8">
        <location>
            <begin position="73"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="47"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="92"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ83661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="367" mass="40299" checksum="34C87BFB1D3968EA" modified="2006-03-21" version="1">MSHAGKCHHDTTEEFSSIHDDYGYKKLQECILGAVTEKTANYIKQTAEKASKKRAEDAQKQGEEGAQLALQKHRWVPVKLVDRREISDDTRTYTFELPPGRARTWPRDMPAPPKRRDERKPRKNPPTPPESPTTRFHTQPQPQQPPTPNPSSSSTPPPNNHSLHLRPNPSKPTSPRPPKPGGALSNLLDCMPLGEEVEIRGPTGDIVYLGNSEFLITGAFVPQPRRLRFPRVSLVLGGSGITPGYALMAAVMQGMRGGGGEGDGDGTEVRAVDANKSEGDILLKGELDRFERESEGRVKVTHVLSDAGEGWEGERGLVDADLLKKVLFPPEEGSAVFLCGPPGLVRMVALPALKEWGYVEDENLFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPP6</accession>
    <name>Q2GPP6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase lid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227985.1">
        <property type="nucleotide sequence ID" value="XM_001227984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPP6"/>
    <dbReference type="GeneID" id="4396039"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10058"/>
    <dbReference type="eggNOG" id="KOG0742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_306089_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPP6"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF2">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase lid" evidence="2">
        <location>
            <begin position="866"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="968" mass="108813" checksum="FC4BAFCAA122C84E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPU1</accession>
    <name>Q2GPU1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_10013</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227940.1">
        <property type="nucleotide sequence ID" value="XM_001227939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPU1"/>
    <dbReference type="STRING" id="306901.Q2GPU1"/>
    <dbReference type="GeneID" id="4395924"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10013"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_18_2_1"/>
    <dbReference type="InParanoid" id="Q2GPU1"/>
    <dbReference type="OMA" id="AFIWIYI"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF6">
        <property type="entry name" value="MSTA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208864" description="Major facilitator superfamily (MFS) profile domain-containing protein" evidence="8">
        <location>
            <begin position="17"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ83609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="180" mass="19754" checksum="15CD133B8B3096F9" modified="2006-03-21" version="1">MLICQFLVAIIGVTVGFNHTHPDPLDPKGSIANNISAVNAQIAFIAIFIFFFASTWGPGAWIVIGEIFPLPIRSRGVGLSTASNWLWNTIIAVITPYMVGETRGNMKSSVFFVWGGLCTCAFVYTYFLVPETKGLSLEQVDKMMEETTPRTSAKWKPTTTFAGHQASEDAFLKQHGDTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQ28</accession>
    <name>Q2GQ28_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_09926</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227853.1">
        <property type="nucleotide sequence ID" value="XM_001227852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQ28"/>
    <dbReference type="STRING" id="306901.Q2GQ28"/>
    <dbReference type="GeneID" id="4396477"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09926"/>
    <dbReference type="eggNOG" id="ENOG502RM4B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035914_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GQ28"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF125">
        <property type="entry name" value="N-ACETYL-6-HYDROXYTRYPTOPHAN OXIDASE IVOB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208877" description="Tyrosinase copper-binding domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ83522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="376" mass="40649" checksum="838C3F29E1D38D4A" modified="2006-03-21" version="1">MKLSASIALAAAMGASATFNLPAFEQLAIDSGLALSGLNGLALLQSATKYGGSCNIGNVKIRREWRTLSKAQRKSYIKAVQCLQKSPSLLPAGVSAGSKTLFDDFVYVHLQSTPFIHFTGNFLIWHRNYIHEYEEEGSMPVVTRWSFDASAPHLSPIFDESDTSMSGDGEFIPGPDLSLEIPGNAEPVVLKKGTGGGCVKTGPFADMTVRLGPITQPDPTADNPRCLKRDLNADAGSRFSSFRNTTDLIINSPNIEIFRTTMEADPNYIPNSLGVHGGGHFMISGDPGSDAFISSGDPAFYLHHAQIDRVYWIWQMLDFQNRQGVFGTNTLLNAPPSANTTVEDTVDVGHIGAPIKIKNLMSTTGQNGSPLCYIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQH9</accession>
    <name>Q2GQH9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-(3-amino-3-carboxypropyl)histidine synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227702.1">
        <property type="nucleotide sequence ID" value="XM_001227701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQH9"/>
    <dbReference type="FunCoup" id="Q2GQH9">
        <property type="interactions" value="852"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GQH9"/>
    <dbReference type="GeneID" id="4396650"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09775"/>
    <dbReference type="eggNOG" id="KOG2648">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015210_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GQH9"/>
    <dbReference type="OrthoDB" id="449241at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="50279" checksum="4E0F0C8012D83970" modified="2006-03-21" version="1">MATELSAAPVLSTPAEQGFEYAVVPSETEAQLPPRDDEELLIRYDIAGTAIRARQKGWKRFSECISRLLEKITILADTSYSACCVDEIAAEHADADVVVHYGRSCLSPTSRLPVIYVFTYHNLDRDETVAAFEKQYPDKDTAVVLMADVTYQEHIRTLASKLHIRRGYTNLLSTDVIHDPTGLIPNRRLVIPRETPELDPFPTTLSADALKTHSIFHISQPPTALLLALASRVHSLHIHPTPSSPTTSLATNPQQFSTPRLLRRRYARLLTLASAGIVGILVIRSRSPLPVLGRHDPQADRRVPNASWWGGIERVGEGVGGAGGVDEGEQGLQEEEGVGSGVEAGLDEDDDEEESAPPEFDLRTGKLVSHSRPMRNGAGKANGKSKAEGVAAGTEAKSSSALALRPKAELATVNGVVSPGAEYLRAQRTWQGLGSDYVAEESTAIEEGRSGIARGYTVGSEERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQZ4</accession>
    <name>Q2GQZ4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Flap endonuclease 1</fullName>
            <shortName evidence="15">FEN-1</shortName>
            <ecNumber evidence="15">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CHGG_09610</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleoplasm</location>
        </subcellularLocation>
        <text evidence="15">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="15"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227537.1">
        <property type="nucleotide sequence ID" value="XM_001227536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQZ4"/>
    <dbReference type="FunCoup" id="Q2GQZ4">
        <property type="interactions" value="933"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GQZ4"/>
    <dbReference type="GeneID" id="4396745"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09610"/>
    <dbReference type="eggNOG" id="KOG2519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032444_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GQZ4"/>
    <dbReference type="OMA" id="IQEVHID"/>
    <dbReference type="OrthoDB" id="1937206at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000009">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000003">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 15" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 15" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="18">
        <location>
            <begin position="9"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="17">
        <location>
            <begin position="129"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="342"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAQ83206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="378" mass="43047" checksum="9F173B18313495D9" modified="2006-03-21" version="1">MPSRKATSKVNSAARLQFSMSIYSFLIAVRSDGQQLMNESGETTSHLMGMFYRTLRMVDNGIKPLYVFDGAPPKLKSGELAKRFQRKQEANEGLEEAKETGTAEDVEKFSRRTVRVTREHNEECQRLLKLMGIPYILAPTEAEAQCAVLARAGKVYAAASEDMDTLCFNTPILLRHLTFSEQRKEPIQEIHVEKVLEGLNMERKQFVDLCILLGCDYLDPIPKVGPSTALKLIREHGSLEKVVEFMKNDPKSRYTVPDDWPFEDARDLFFSPDVRQADDPLCDFKWDKPDMEGLVKFLVQEKGFSEDRVRSGGARLEKNLKSSQQSRIEGFFKVVPKTEAERAAHKRKLEEQNEAKKKKIKEEKKEKAKAKAKPRGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRF7</accession>
    <name>Q2GRF7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227374.1">
        <property type="nucleotide sequence ID" value="XM_001227373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRF7"/>
    <dbReference type="GeneID" id="4395552"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09447"/>
    <dbReference type="eggNOG" id="ENOG502SYRM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_670893_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRF7"/>
    <dbReference type="OrthoDB" id="4571402at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="402" mass="47073" checksum="7D3F145397AEE43A" modified="2006-03-21" version="1">MFGSLLDLPPPLRRLLWWGFLITLPFHFAPFLNGLIEGVIYSNFLTETYFASLDHFSFNVQTAQWADPWSDPSSVIGHEPFYVVQLHDPQRWWEKLGLKRFDIDITDDVAMANIPIDSFASLEALYRRAPKQEQAQPWHHFIYASPSVIHIEDIWLDKWDRAFNELLQYHYANPTPTGAGFHYLSCWRSFLCDIWATRGPALLHFTTESPDPSNKLDELNQRQQIPGYLPVVVRIIEFPLTEPDKLGLPPSQFPSHFNQLRSVTSQPQMWQLYKPFNKMAQVMKRLADRCSKAEKKYAQTYGRLYKLEIWIQNMLGLESSPWPGLARIPAIALSSGVSQVLGRAWEFVEPQARALHKRYWDKKKNQEPLERLDERTKWKRDDDEETRGKRDGDEETRWKRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRH4</accession>
    <name>Q2GRH4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Terpene synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227357.1">
        <property type="nucleotide sequence ID" value="XM_001227356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRH4"/>
    <dbReference type="STRING" id="306901.Q2GRH4"/>
    <dbReference type="GeneID" id="4395070"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09430"/>
    <dbReference type="eggNOG" id="ENOG502SPMF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042677_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRH4"/>
    <dbReference type="OMA" id="IYCPRYH"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="42757" checksum="CBA939FEA8F63827" modified="2006-03-21" version="1">MADDHHNDNHHDHSQPPPTAEPTSPTAEPLSLAHYNTHGFCQHQSPTFPLARHRHEALANAGCQAARRDWARLIGPGAPHEFGACNPVNGNFVALLFPLCRVERLGVVGYVVEYSFLHDSVVEGLGEESSAQPDKFGLGELETTRPNIKAGRKQMQAKIVSLLSDIDKAGAARIMAVWKAMLSRTLRDKTKDFANLEEYIEFRSIDTGGAFGEALMLFGLGMTLTAEEDALLAHITQPCYASFALVNDYFSFDREWGDTQSKPGASKPIINAVWLYMQWRGVSVAVAKRLVAAASNRYEARFLELCERFRNEHKPISPKLDLYLRGLSYQVSGNVVWSLNCPRYYPGFRYDPNAGLEDTITLGLRAKKRLAGERDAESSVVLHCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRS4</accession>
    <name>Q2GRS4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit tim-17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_09330</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227257.1">
        <property type="nucleotide sequence ID" value="XM_001227256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRS4"/>
    <dbReference type="FunCoup" id="Q2GRS4">
        <property type="interactions" value="1003"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GRS4"/>
    <dbReference type="GeneID" id="4395525"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09330"/>
    <dbReference type="eggNOG" id="KOG1652">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087811_3_0_1"/>
    <dbReference type="InParanoid" id="Q2GRS4"/>
    <dbReference type="OMA" id="FDCTFQY"/>
    <dbReference type="OrthoDB" id="2261329at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF0">
        <property type="entry name" value="AT05822P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ85316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="151" mass="15857" checksum="132E294E81BFDFEF" modified="2006-03-21" version="1">MDHTRDPCPWVILNDFGGAFCMGAVGGTIWHGVKGFRNSPYGERRLGAITAIKMRAPVLGGNFGVWGGLFSTFDCAVKGVRKKEDAYIAGFFTGGSLAIRGGYKAARNGAISCAILLAVIEGVGIGFQKMFAGSTKLEAPQPPPSGEQMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSB4</accession>
    <name>Q2GSB4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="12">DHBP synthase</shortName>
            <ecNumber evidence="3 12">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_09140</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3 12"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227067.1">
        <property type="nucleotide sequence ID" value="XM_001227066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSB4"/>
    <dbReference type="FunCoup" id="Q2GSB4">
        <property type="interactions" value="111"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GSB4"/>
    <dbReference type="GeneID" id="4395823"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09140"/>
    <dbReference type="eggNOG" id="KOG1284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020273_3_1_1"/>
    <dbReference type="InParanoid" id="Q2GSB4"/>
    <dbReference type="OMA" id="DAGGLIC"/>
    <dbReference type="OrthoDB" id="60371at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000002">
        <property type="entry name" value="3,4-dihydroxy-2-butanone 4-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF18">
        <property type="entry name" value="3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0318">Glutathionylation</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0686">Riboflavin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ85126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="235" mass="24617" checksum="EEEB0F11232C2424" modified="2006-03-21" version="1">MPSTAPADQIPASQFDSIPDTIQAFAAGEFVVVLDDPSRENEADLIIAAESVTTEQMAFMVRYSSGLICAPVPASRAAALALPPMVAVSQDPRGTAYTVSVDAADPSVTTGISARDRALVCRALADDKAGPGDFRRPGHVFPLQAQAGGVRQRPGHTEAAVDLCRLAGKKPAAVICELVDDGAEVPGRAIREEPGMLRGEACVAFARKWGLKVCTIADMVAYLEKVEGKIEVNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSL8</accession>
    <name>Q2GSL8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226963.1">
        <property type="nucleotide sequence ID" value="XM_001226962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSL8"/>
    <dbReference type="GeneID" id="4394861"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09036"/>
    <dbReference type="HOGENOM" id="CLU_1777216_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSL8"/>
    <dbReference type="OrthoDB" id="10476286at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="146" mass="16049" checksum="6654EB1E406B07E3" modified="2006-03-21" version="1">MIMVLTWHDFETCFSRREGHRGSLLGLCSLRFLQIIGAYLFIHGVFPSGGEIYAQVYIRAKNVHPSRSGRSSYDYFDDEPMRHAPAGPREGLGMPGTAGDDLHSPAQNANARSGLPEQKRARESFAAAALSEEGSKHAAVCISVWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GT27</accession>
    <name>Q2GT27_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226804.1">
        <property type="nucleotide sequence ID" value="XM_001226803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GT27"/>
    <dbReference type="GeneID" id="4395607"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08877"/>
    <dbReference type="eggNOG" id="ENOG502SQZA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038508_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GT27"/>
    <dbReference type="OMA" id="RYEETAY"/>
    <dbReference type="OrthoDB" id="5401654at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="410" mass="42515" checksum="DB84AF5171788C7A" modified="2006-03-21" version="1">MPDLNSVPPSPHALAGLSRRASSQQMPPPPAPGSPSLNILPSNQSTVNASIPPSLPSPGFQASTSFPGPTMNDNTGVGPGPGPLRHPRPLTAADLHLELEKEQEAVVNRLTRELSILRAAQNASVVSNASSTSASASGTEPGQWGDMSQPSLGTSHYQPVRHQRTSSSASARSLTANAGSVSTTSLAGISSPVPVRPTAQTPIAIGGIALSRQNSSASRRSRTGSPSPAAHRSSSSSHPYHHHHATPGSEPGSLPGYFTSRMPMPMRSQSGTGTGTTPTSAAITPITTTTASELSPGILPATSRYEETALRRAELDEYKRENEALRRRVRELERLVRDAAALKEQSQQSQPQQAQSLPQQQQQVARQRAVSTASAAGSAVGVGVPEEEVGVGESAASGGAGRGRRVGRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GT49</accession>
    <name>Q2GT49_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_08855</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226782.1">
        <property type="nucleotide sequence ID" value="XM_001226781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GT49"/>
    <dbReference type="FunCoup" id="Q2GT49">
        <property type="interactions" value="886"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GT49"/>
    <dbReference type="GeneID" id="4395813"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08855"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005210_4_0_1"/>
    <dbReference type="InParanoid" id="Q2GT49"/>
    <dbReference type="OMA" id="RPAKLTY"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00625">
        <property type="entry name" value="RCC1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="183"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="185"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="319"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="372"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="429"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="486"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="551"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="254"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="39"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ84841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="607" mass="64213" checksum="39F0B557C324EB01" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GT86</accession>
    <name>Q2GT86_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226745.1">
        <property type="nucleotide sequence ID" value="XM_001226744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GT86"/>
    <dbReference type="GeneID" id="4394868"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08818"/>
    <dbReference type="HOGENOM" id="CLU_2145583_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GT86"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="112" mass="11521" checksum="6A2038452698A452" modified="2006-03-21" version="1">MRKSTTATPRYSSSGSNSRTSASHSRSSGSGSSSRNARAPTAHGSTARSGGGSGGGGGPVNQRYPLNCWHCKMNLDVSTYVCPGVDCGVRPFMACGYPGCSPNAPRHVPHSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTE7</accession>
    <name>Q2GTE7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_08757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226684.1">
        <property type="nucleotide sequence ID" value="XM_001226683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTE7"/>
    <dbReference type="GeneID" id="4395336"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08757"/>
    <dbReference type="HOGENOM" id="CLU_2209732_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTE7"/>
    <dbReference type="OrthoDB" id="10383677at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="107" mass="12148" checksum="0B4A7431445B4BFE" modified="2006-03-21" version="1">MPTFRQQRQTHLRMLEVPDPPSLGRYVCDEIVPRFLDSSYEGEEKAIRKLKTQASMLRIEPSFSTNTRVAAGAGTTSRDGFVDFAEVMKVDTQVNNGKVLAFPKRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUR9</accession>
    <name>Q2GUR9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_08285</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a component of both the DNA-binding general transcription initiation factor complex TFIID and the transcription coactivator SAGA complex. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TAF10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ87032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225941.1">
        <property type="nucleotide sequence ID" value="XM_001225940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUR9"/>
    <dbReference type="FunCoup" id="Q2GUR9">
        <property type="interactions" value="376"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GUR9"/>
    <dbReference type="GeneID" id="4394499"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08285"/>
    <dbReference type="eggNOG" id="KOG3423">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064104_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GUR9"/>
    <dbReference type="OMA" id="QNGSQEH"/>
    <dbReference type="OrthoDB" id="154356at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017246">
        <property type="entry name" value="TFIID_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="137"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ87032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="202" mass="21368" checksum="4505DC663FBEF06D" modified="2006-03-21" version="1">MATNPSMDNAEQMTATAANPNGAQPSEATEVNADDAPAPTVTEPKLPTRKDASLKEFLNKMDDYAPIIPDAVTNYYMTRAGLPPPPQTDQRLARLLALATQKFIADIAADAYQYSRIRASNTNANNPMGNLGAAAGFPIPGQPTNQPGNKDQGRGGPLGIQRPGYGGGGQGGSQNRTVLTMEDLGMAVGEFGVNVKRSEFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUU1</accession>
    <name>Q2GUU1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Early meiotic induction protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ87010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225919.1">
        <property type="nucleotide sequence ID" value="XM_001225918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUU1"/>
    <dbReference type="STRING" id="306901.Q2GUU1"/>
    <dbReference type="GeneID" id="4393341"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08263"/>
    <dbReference type="eggNOG" id="ENOG502S4MN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074897_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUU1"/>
    <dbReference type="OMA" id="FGGQWVN"/>
    <dbReference type="OrthoDB" id="2017405at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="33037" checksum="4A51DF09FE363830" modified="2006-03-21" version="1">MGWFWQAPSSPKPAGSRDSASPTPNTPTPPAPTAPTQTPPAEAESNSTDREMAMFMNMLLKDTQSSSSQSKTQQPTSPPSPPSKSSSSWLPWSSTKPDTTPTTEQQTTPPKQTRSPQSLAMSEHLLPTTMSCRDAFDYAWHCHTPGAQWNAVYRYGSVRPCTELWDDFWFCMRTKSYSPELKAEAIREHYRAKEEAKYGGGRPSSEDVWASRTERVAPGTAFQQSFEPPVIDDAAFQRMDAERRRRIREMAGSEGNNSDNNTQPHNLHDRTPSIDLVTDGEFPTDGSIVVHERKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUV6</accession>
    <name>Q2GUV6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225904.1">
        <property type="nucleotide sequence ID" value="XM_001225903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUV6"/>
    <dbReference type="GeneID" id="4393639"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08248"/>
    <dbReference type="eggNOG" id="ENOG502RJNJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_774297_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUV6"/>
    <dbReference type="OMA" id="RYLECDE"/>
    <dbReference type="OrthoDB" id="3437607at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="349" mass="38704" checksum="F69C953874C1DEEB" modified="2006-03-21" version="1">MLRPRPSVISLTRADVTDVVHRRRFRRYLECDEGNVCVDFAPVEIDTTFKLDRHATPPSRTAQRKTTPTTYDNTQNSSPIINGGAHHWVTDVPLLLLSDKETGEDVSPPHEVSASQVRRLRTRGKSQQGSEWTLQLCLRPKPGLPNATTPAKDDGSTDSQDSRENPAPFLEDSTDFRLKSDAGPSTPRRGLPPGSPGNPPTAPIASSRVSRRSFDTSDIRRDDRSSSEISSPSPTFMNRGRLRIYNDFLPVSSQPQTPQNLPRARRQNRLQGSYTAPARRISPQPDLATATIRPRRTRQRRREPSPLGLRTSRLPGSDADTENMDDAALLEGVAGDMARSWASPSRSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV17</accession>
    <name>Q2GV17_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RuvB-like helicase</fullName>
            <ecNumber evidence="16">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_08187</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="function">
        <text evidence="15">DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="16"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225843.1">
        <property type="nucleotide sequence ID" value="XM_001225842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV17"/>
    <dbReference type="FunCoup" id="Q2GV17">
        <property type="interactions" value="1282"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GV17"/>
    <dbReference type="GeneID" id="4393348"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08187"/>
    <dbReference type="eggNOG" id="KOG1942">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028311_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GV17"/>
    <dbReference type="OMA" id="RTLPYNK"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="36"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00055509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ86934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="389" mass="42543" checksum="F8399A2E273CE1BF" modified="2006-03-21" version="1">MFPLIQLHLAVSHTSVNIEISKAAGFVGQSSAREMAGRGVLLAGGPGTGKTALALAISQELGTKIPFCPITGSEVYSTEVKKTEMLMENFRRAIGLKVRETKDVYEGEVTELTPEEAENPLGGYGKTISTLLVGLKSARGQKKLRLDPSIYEAIQKERVQVGDVIYIETNTGACKRVGRSDAYATEFDLEAEEYVPIPKGEVHKKKEIVQDVSLHDLDVANARPQGGQDIMSMMGQLMKPKMTEITDKLRGEINKVVSKYINQGVAELVPGVLFIDERRTACPPDFLTRLLIIPTHPYEPEEIKRIVRIRATTEGVQITDAAIDKIAEHGVRISLRYCLQLLTPASILARVNGRAQIDVPDVAECEDLFLDARRSANVLASESGAGFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVD0</accession>
    <name>Q2GVD0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_08074</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225730.1">
        <property type="nucleotide sequence ID" value="XM_001225729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVD0"/>
    <dbReference type="STRING" id="306901.Q2GVD0"/>
    <dbReference type="GeneID" id="4394510"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08074"/>
    <dbReference type="eggNOG" id="KOG0297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019709_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GVD0"/>
    <dbReference type="OMA" id="PLTTICG"/>
    <dbReference type="OrthoDB" id="1630758at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF94">
        <property type="entry name" value="TNF RECEPTOR-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02176">
        <property type="entry name" value="zf-TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="7">
        <location>
            <begin position="172"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="4">
        <location>
            <begin position="172"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="273"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="390"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="432"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ86821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="49597" checksum="D5EC789F8EA87E35" modified="2006-03-21" version="1">MPPPNTPEEGVAATTLRPADDDNFRASSPSSAMAHASQEDATPFHSPITTPCGHTFCAGCINRALETQPRCPIDRQPINKTCDYGRLPLIIKEQLDRLQVRCPNKGCDYQCPREHLEGHYERRCEYTQVRCPDSTCSRLTPRRDSAVENGCLHKDAICEFCHKTVAFVELSTHYNFDCEGAMAECPECKEQVVRHCLVKHRAQDCAEETTSCKWHTGGCKVVDKRRIVQDHEQSGCPSEAVGRLIQQQVEDRKIIDELVRRLNKFELAQGKNPERRFTQRARVGSSMASSSRNPTSANVPDITLNNNMPPLFPDSTDDGAVGGSPEDYLLAQFERLETEVELLRKQALEMDAHRSHIIHQQATHFNEHLAEIGNKVGVVNMHMSWLMSLQRQSHAQQRAGSTAGSANSGMSHGSATSGARPGSSGEGSSTGESRRSSEGRSETLHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVX7</accession>
    <name>Q2GVX7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-end rule aminoacyl transferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_07877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001225532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVX7"/>
    <dbReference type="STRING" id="306901.Q2GVX7"/>
    <dbReference type="GeneID" id="4394531"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07877"/>
    <dbReference type="eggNOG" id="KOG1193">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020349_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GVX7"/>
    <dbReference type="OMA" id="KMQYKND"/>
    <dbReference type="OrthoDB" id="74183at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="2">
        <location>
            <begin position="99"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ86624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="415" mass="47110" checksum="B1A0EADCBC2D1E63" modified="2006-03-21" version="1">MQKHSCCPHYTLRLDSTQFKPTKDQRQAVNRFNRHIIGDTYAREAARLHPRSRAEVRRRHNVFDLVERIHEPEAEVLKSPPSPDHAFTVTLEPDTFTEEKYEIFENYQRIVHREPQDKVSRHGFKRFLCNSPLSRGSMVGPDGKERKLGSFHQCYRIDGKLVAVGVLDLLPDCVSAVYFLYHESIHWLNPGKLGALREIALAREAGYRWWYPGYYVHNCAKMRYKIEYKPQYVLDPEDLQWYLLDKEALDKFDKEHYVCFSRTEQAVGHADTKEHGVNGANGIDKAVDTVATGNHNATEGSQKADEASPSPSSAEQAATEEAEAEAEEEEDGFLLASNMPGIPTLAEMEEVDMDGLVLRSDFSDTFIVASHLVIWDTEHVSQFGSLKSRIAELVAAVGPDLIGDICIDFRKRSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GW15</accession>
    <name>Q2GW15_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225495.1">
        <property type="nucleotide sequence ID" value="XM_001225494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GW15"/>
    <dbReference type="STRING" id="306901.Q2GW15"/>
    <dbReference type="GeneID" id="4393166"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07839"/>
    <dbReference type="eggNOG" id="KOG0274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2621814_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GW15"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="78" mass="8418" checksum="1705A957FFA40F3C" modified="2006-03-21" version="1">MQSVNPEHFFKTNAAQEKRHRRAAKAGNKYGNPISLKSKILAAVPDPRSPSSAILVAESAGAVRLVKLNVVCLTDYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXP3</accession>
    <name>Q2GXP3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sacsin/Nov domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_07261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224917.1">
        <property type="nucleotide sequence ID" value="XM_001224916.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4394627"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07261"/>
    <dbReference type="eggNOG" id="ENOG502QPMA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001744_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GXP3"/>
    <dbReference type="OMA" id="VYWWVIL"/>
    <dbReference type="OrthoDB" id="10031156at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022155">
        <property type="entry name" value="DUF3684"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12449">
        <property type="entry name" value="DUF3684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacsin/Nov" evidence="2">
        <location>
            <begin position="26"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1403"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1415"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1437"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1486"/>
            <end position="1500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ86008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1704" mass="187727" checksum="B149D8C20DB27D8D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXS4</accession>
    <name>Q2GXS4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1754-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224886.1">
        <property type="nucleotide sequence ID" value="XM_001224885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXS4"/>
    <dbReference type="STRING" id="306901.Q2GXS4"/>
    <dbReference type="GeneID" id="4393154"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07230"/>
    <dbReference type="eggNOG" id="KOG3410">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098435_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GXS4"/>
    <dbReference type="OMA" id="QLSEHHD"/>
    <dbReference type="OrthoDB" id="205403at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013865">
        <property type="entry name" value="FAM32A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282:SF6">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08555">
        <property type="entry name" value="FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="17613" checksum="AA642CAA6897759D" modified="2006-03-21" version="1">MPADEYAPVARGPLRLKGAAGVTKKKKKKSAKSSTSSSTTDLAKNLATGDVGAGDGGRSGALVLVGEEGDELEREKGKGEGRRDKEGGDGDGEEGEGEEEEEENKTETERRFAEAKRKRLKELTESGRIRPELLKTHKQRVEELNAHLARLSEHHDMPKIGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXZ1</accession>
    <name>Q2GXZ1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224819.1">
        <property type="nucleotide sequence ID" value="XM_001224818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXZ1"/>
    <dbReference type="GeneID" id="4393563"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07163"/>
    <dbReference type="HOGENOM" id="CLU_1042074_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GXZ1"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="267" mass="28619" checksum="CA96D4EAF3109DE4" modified="2006-03-21" version="1">MAPRVESSRDSKTPIQTSSRQRTRHVSSGGCRKGRQRLAAQLCKPQRAREEMLNHLHLLRGQSRQPSAALGSLVLSPVSFFVFPQLLPCAPLAESRARYEVSQAYPGCSIHSRAAMALMSLNDGGMPPPLSRVVSGHTSPVGGVEMIHSQEMISRVQRLGPFSPLSPFVYAHSTLASSSFEPALLNSVSSAAQLPSIWRAGGCPELCSADLAGPPAVTLQAPPSSQTCSDAEDLTDSEDVPLFWLGFALFCLPTLLSIVREETQTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GY95</accession>
    <name>Q2GY95_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224715.1">
        <property type="nucleotide sequence ID" value="XM_001224714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GY95"/>
    <dbReference type="GeneID" id="4393749"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07059"/>
    <dbReference type="eggNOG" id="ENOG502T426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_796933_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GY95"/>
    <dbReference type="OrthoDB" id="3993201at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="348" mass="37799" checksum="5771995E0C4C7F39" modified="2006-03-21" version="1">MYEVHTRLLSALEKGEEDEVTSSTPRHVLVSILPARRYSFARGSLRLWGLGMALSWLYGPRESRSNSIPTDVSHRQPHGVGEPRSLEAEEKRGLPGVTGTRSETVRDSVCWTRDLLTKPGTRAKLDEAAPQLIALKVDRLSLGGTLDGPSSLNNSKSKTEQASLTLLSPQRQHSTHATTTTTPHRPVITAPTTRTIPFMQTFHHSAPKPIAPTFSTIDRAILPDLSFDTSTPIDPYAHIRVPLLPDNTSPSPLHPRQPEAADEPLRQPEILVVAADPSRVLPAALTEVEGMGVDGVELGFVHLLGREKEAEESYEMGPGMIRDLWRGMVEDVLGPVGRSSGGKGAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZ75</accession>
    <name>Q2GZ75_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_05171</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224385.1">
        <property type="nucleotide sequence ID" value="XM_001224384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZ75"/>
    <dbReference type="STRING" id="306901.Q2GZ75"/>
    <dbReference type="GeneID" id="4392609"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05171"/>
    <dbReference type="eggNOG" id="ENOG502RYSN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031730_4_2_1"/>
    <dbReference type="InParanoid" id="Q2GZ75"/>
    <dbReference type="OMA" id="PVQFYMA"/>
    <dbReference type="OrthoDB" id="5271017at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208767" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="17"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="16"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ88552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="213" mass="22641" checksum="1315F83699793AFE" modified="2006-03-21" version="1">MKVLPSLLLMAATADAHFRQTKNYQGNFGVTDVNSQDIRCFQMKPGTSTATVKAGEKLGFVAMSSITHFGPVSFYMARVPEGANINTWEAAGNVWFKVAEISAVAGAGGLTSGEATWPAYNKQTVEFTVPKSVPSGKYLVRVESIALHQAQNPGGAQIYLSCAQIELTNGGNGSPGPLVSFPGAYGTNDPGLLWSYYPVRTSYKAPGPNVWQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H073</accession>
    <name>Q2H073_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_04823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224037.1">
        <property type="nucleotide sequence ID" value="XM_001224036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H073"/>
    <dbReference type="GeneID" id="4392671"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04823"/>
    <dbReference type="HOGENOM" id="CLU_946647_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H073"/>
    <dbReference type="OrthoDB" id="4590459at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ88204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="294" mass="33392" checksum="A6524E5E2F88A776" modified="2006-03-21" version="1">MSTAAKNRASLTQCAQSRYFISLGSPSADELIESIPAQVAGHSPGLPLRIDFCWPEDEVEILDERLAQVSDISNHMSRFQYDYNSKTVSLTMGKSQGHAYLAGNFCVLIQEKLRNFTLTSGWERVPEELAVRVRRVRPFFTASVQVKGLGKARVSVLAADNNDGNGDSSADGFYWGKRGEVFHSEFNPLFHRPPQFSISYRELGALFRIARHLARPDQFDVREEDEDIVDETFQQHDLKLQRQLREAEERSAQAVLGAEERIARERHRRLEAEERFARLLAALAPQNQPDSEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0D8</accession>
    <name>Q2H0D8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Squalene monooxygenase</fullName>
            <ecNumber evidence="16">1.14.14.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CHGG_04758</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>squalene + reduced [NADPH--hemoprotein reductase] + O2 = (S)-2,3-epoxysqualene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25282"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Endoplasmic reticulum membrane</location>
            <topology evidence="3 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the squalene monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.17" evidence="16"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223972.1">
        <property type="nucleotide sequence ID" value="XM_001223971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0D8"/>
    <dbReference type="FunCoup" id="Q2H0D8">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H0D8"/>
    <dbReference type="GeneID" id="4392083"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04758"/>
    <dbReference type="eggNOG" id="KOG1298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026390_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H0D8"/>
    <dbReference type="OMA" id="AKRTFYW"/>
    <dbReference type="OrthoDB" id="1678617at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004506">
        <property type="term" value="F:squalene monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000166">
        <property type="entry name" value="Squalene monooxygenase Erg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013698">
        <property type="entry name" value="Squalene_epoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040125">
        <property type="entry name" value="Squalene_monox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835:SF0">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08491">
        <property type="entry name" value="SE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 16" id="KW-0274">FAD</keyword>
    <keyword evidence="5 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="456"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="17">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene epoxidase" evidence="18">
        <location>
            <begin position="204"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAQ88139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="509" mass="55642" checksum="D82F75C8F09C2DD0" modified="2006-03-21" version="1">MAGVADSEAARNVERREQHHEADIVVVGAGIFGCAAAFALANQGRSVILLERWMHEPDRIVGELLQPGGVDALRKLGLEHCLEDIDAVPCQGYHVILRGQETSFLYPPLTGDGEVIVGAGQRKEVNEYANGDVKEPVRPEGKCFHHGRFIMQLRKACIAHPNISVFETEVTATIKGEHSDAVLGVRTRTKDPATGNKTPDCFFGQLTIIADGYNSIFREELLGTTPRVRSKFYALELIDCPFPPAYHGHVVIGEQSLALLYQIGTHETRALIDIPTNHPAATPKAGGARGFIENIVLPSLPPHVQPSVRAALADGKIPKSMPNSWLPSTKQTHHDGVIILGDAHNMRHPLTGGGMTVAFNDAVLLSSLLSPTQIPTLTHHAAVHRAMATFYWRRKSLTGIINVLAQALYSLFAADDWQLRALQRGCFRYFQDGVTDEPVAMLGGVLRRPLTLARHFFTVAFLSIRLHTVALCGGSVLGWLKLPLAMVHAVMILWTACVVFLPVLWAESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0E4</accession>
    <name>Q2H0E4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223966.1">
        <property type="nucleotide sequence ID" value="XM_001223965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0E4"/>
    <dbReference type="GeneID" id="4392262"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04752"/>
    <dbReference type="eggNOG" id="ENOG502RJJ2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_576434_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H0E4"/>
    <dbReference type="OMA" id="NAIPIWI"/>
    <dbReference type="OrthoDB" id="5332316at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="488" mass="51463" checksum="48471882FE259E01" modified="2006-03-21" version="1">MLGPSAAAQVAREEPKPEPELEPELPSGKPVLVLSSMSRSLVASDFYRWAPQGRHVAGWAGGISKVVQSVSPVTREPRGQYFLFFDTWDAAYRCRDQFRKAYQLTNKNESPGQLKTPPALKGPTSFSTCAARLRSSMARGETMVTVFLSFLDCSGEACGGGSKLALDGDGRYAGEVLERVRPRGGASDVWEAIPIPVAAMLPDCRLGVCGKRVNAGDFMGCGEVALRGFVLSCSSRCSILSLMVLSFSSVAWRRSNNDDLVPFGFNTPLNMTLYRSSLMSGMSMLSNPAPPVDVEGMGAETTGMFGCGTTASACDIVMDLMTMGLCFGVFLPATVLLLAGVDESLDTYGVESWVGLPNAIPIWISPEAEDWGVGSMAGGDMADDGDAIRDLWGLGSGAMSSLDSLLSSLDFVAPDLLEPGPEDVLGLAGMLSGAVLLGAPAMFLDGGGGRGRVEIRVPPSGKRDGGDVGILKWVSVPSAGILWMQGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0G3</accession>
    <name>Q2H0G3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="4">1.4.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_04733</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="4"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223947.1">
        <property type="nucleotide sequence ID" value="XM_001223946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0G3"/>
    <dbReference type="FunCoup" id="Q2H0G3">
        <property type="interactions" value="374"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H0G3"/>
    <dbReference type="GeneID" id="4392481"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04733"/>
    <dbReference type="eggNOG" id="KOG2586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032263_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H0G3"/>
    <dbReference type="OMA" id="AYFRTRP"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
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<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
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    <sequence length="581" mass="62421" checksum="8D3E31D39651A705" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223639.1">
        <property type="nucleotide sequence ID" value="XM_001223638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1C1"/>
    <dbReference type="STRING" id="306901.Q2H1C1"/>
    <dbReference type="GeneID" id="4392517"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04425"/>
    <dbReference type="eggNOG" id="ENOG502S130">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_789884_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H1C1"/>
    <dbReference type="OMA" id="WRTLTED"/>
    <dbReference type="OrthoDB" id="4842715at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ87806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="38586" checksum="991A064059A17082" modified="2006-03-21" version="1">MDRKRVKAESALLCKIMGLADPGPDGLPTRTRTVEGLDKALDSLASCGYSSPWWTVEVQQAAREARRAERLTKETRAEYCWEELSERLKDLARTTREARTRAWRNSLQEASEAKKPDQMWSLERWARLRSFLPPEPPRLPEFKDSSGQVTAETHDRKASALAERFFPDPPANPTDVEDQAFLGSWNPGFDVVQAVTPTEITEAIGRASPWKAPGEDLLPMGLLKACGAPLAEVLALLATRCLELGWFPNRFKRAKTVVLPKPVKAPPAYQTPGGYRPIALLPTLGKVIESVVARKVTQAAEVNGLLPDEQMGNRAHRSTELAVRRVGSLGPGGVETEGCGIPIATGHLRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1Q3</accession>
    <name>Q2H1Q3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_04293</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223507.1">
        <property type="nucleotide sequence ID" value="XM_001223506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1Q3"/>
    <dbReference type="STRING" id="306901.Q2H1Q3"/>
    <dbReference type="GeneID" id="4392646"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04293"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H1Q3"/>
    <dbReference type="OMA" id="TWHHRVQ"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="101"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ87674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="274" mass="30031" checksum="9E573CB680062035" modified="2006-03-21" version="1">MAETKNTSKTFQLNTGKTIPAIGLGTWQSQPGEGDRRGASAASGRAARGDLPDQPSSTTPGTSGPLKRSSARSKTWAWITSTYTSCTGPSSTTPEDLKKHYPDWDFVDTWREMQKLMDTNKIRNLGVSNFGIKNLERLLNDPSCKIVPAVNQIELHPGNPSPKLIAYCAEKGIHCSGYSPLGSSDSPLYKNETIASIAKAKNRSVQQVLLMWGVKKGWSVLPKSVNPDRVKANFDLDGWDLTDEEVAKIDSIPDRFKVCGDAWLPIKVFFGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H274</accession>
    <name>Q2H274_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223336.1">
        <property type="nucleotide sequence ID" value="XM_001223335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H274"/>
    <dbReference type="GeneID" id="4391974"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04122"/>
    <dbReference type="eggNOG" id="ENOG502SKGQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027514_2_2_1"/>
    <dbReference type="InParanoid" id="Q2H274"/>
    <dbReference type="OMA" id="FEMILAF"/>
    <dbReference type="OrthoDB" id="3251507at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="453" mass="48900" checksum="E0F0B1C50B41B702" modified="2006-03-21" version="1">MSDPVPLPPSLGRRFYEPIILLSALKGVYGQDKSLVEPDLEGSTGKSPKQVYFCFLNKLSQICDSQKKQDLGKTVSAIVALEPGSIEYRLASNRRDSRELAATTEYLTDILNVLGHVTDGQINDKAFMATVSSDILRKVLGFNRPRIEVYLNELVEANQLGFCIESATTSETPDVLIVTSRQSTAPGTTSATPSAASSPTSSPSKSSSPPASSGHASSSTSRSPTSPPANPNLTRPASGATRKGIIRRMSRSKEIADAYQSHAKHLQAFKLDDRIRKRAKSDSFRPIVHAEVNLLASVLASQAAAEREGEDPLRFFHEADFGAYIGSSKPTCLLCSQYFAAHPGQGRLSRVARQPLPQLARAGRDAGAGPAAAKERCDILEAMVKECARRPRARSGTARIRGGSMIRGVNLDTSSMRAWSDESRETTPRARRIIEEDEEDDDEGGEDGGGVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2L0</accession>
    <name>Q2H2L0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223200.1">
        <property type="nucleotide sequence ID" value="XM_001223199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2L0"/>
    <dbReference type="GeneID" id="4392291"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03986"/>
    <dbReference type="HOGENOM" id="CLU_1981402_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2L0"/>
    <dbReference type="OrthoDB" id="10520706at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="126" mass="13503" checksum="AC7FE708DD8DECA8" modified="2006-03-21" version="1">MKVSSLLSIEKGIGIIITLILQPTIPPTIGNSNRPLQRLESTPQLPQCIPAHLEALRRRQPPVVESTHTQTLQPTPPSPSLTRSAAPCNRCGPLRARSAPPSIRSRAHSPRCDSAAPIIAACPSWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2L6</accession>
    <name>Q2H2L6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GED domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223194.1">
        <property type="nucleotide sequence ID" value="XM_001223193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2L6"/>
    <dbReference type="STRING" id="306901.Q2H2L6"/>
    <dbReference type="GeneID" id="4392076"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03980"/>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008964_7_2_1"/>
    <dbReference type="InParanoid" id="Q2H2L6"/>
    <dbReference type="OMA" id="RMREELW"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF215">
        <property type="entry name" value="DYNAMIN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GED" evidence="1">
        <location>
            <begin position="528"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="616" mass="69902" checksum="B76A3627F9E5A37B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2V9</accession>
    <name>Q2H2V9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_03887</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223101.1">
        <property type="nucleotide sequence ID" value="XM_001223100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2V9"/>
    <dbReference type="FunCoup" id="Q2H2V9">
        <property type="interactions" value="339"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H2V9"/>
    <dbReference type="GeneID" id="4391613"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03887"/>
    <dbReference type="eggNOG" id="KOG2495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019845_6_2_1"/>
    <dbReference type="InParanoid" id="Q2H2V9"/>
    <dbReference type="OMA" id="MAVTHQL"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="4"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ87268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="380" mass="39930" checksum="8D5A8DFF1C392E2E" modified="2006-03-21" version="1">MSKTVVILGGSIGGLHVAHALLKKNIKDTKVILVSKNSHFYWNLASVRAIIPGQIKDEQLFQPLQAALSRYPTESWELVIGSASAADFDAKTVEITLPDGTTRTLPYHQLVLATGARSPSPDTPWKAPGTYEQTLASLHDTAARVASAQHIIVGGAGSTGIEVAGELGYEYGKTKEIVLLCSGDKVAGGSALADAAANELKKLNVTIKYGAHVAEARPAAAAGEGQASKTEVVLASGETLTTDLYLPTTGLIPNTEYIPAQYLVDGAVVRPVQVDEYLRVPGTQEVWACGDIVSKPRAGFFYTQKQAVSVAKNVEAALAGLKPAVAKGPPVDVFACAVGRDRGVGRINNSIKMPSFAVWAAKGRTLALPMVKTYIDGSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3F0</accession>
    <name>Q2H3F0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_06815</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222910.1">
        <property type="nucleotide sequence ID" value="XM_001222909.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H3F0"/>
    <dbReference type="GeneID" id="4391324"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06815"/>
    <dbReference type="eggNOG" id="ENOG502QUFK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000211_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H3F0"/>
    <dbReference type="OMA" id="CIIPMVA"/>
    <dbReference type="OrthoDB" id="3182339at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022099">
        <property type="entry name" value="DUF3638"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022105">
        <property type="entry name" value="DUF3645"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046541">
        <property type="entry name" value="DUF6606"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF32">
        <property type="entry name" value="DUF6606 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12340">
        <property type="entry name" value="DUF3638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12359">
        <property type="entry name" value="DUF3645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20255">
        <property type="entry name" value="DUF6606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUF6606" evidence="11">
        <location>
            <begin position="12"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3638" evidence="9">
        <location>
            <begin position="2074"/>
            <end position="2297"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3645" evidence="10">
        <location>
            <begin position="2394"/>
            <end position="2422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3097"/>
            <end position="3134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3230"/>
            <end position="3262"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="574"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="3099"/>
            <end position="3114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="3243"/>
            <end position="3262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ90196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="3262" mass="367859" checksum="24D86859E5261403" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3R8</accession>
    <name>Q2H3R8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Short-chain dehydrogenase/reductase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_06697</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222792.1">
        <property type="nucleotide sequence ID" value="XM_001222791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3R8"/>
    <dbReference type="GeneID" id="4391203"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06697"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H3R8"/>
    <dbReference type="OMA" id="YMTGTDF"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF63">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ90078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="30237" checksum="4D3A916A371199DD" modified="2006-03-21" version="1">MASSGRGRLAGKNAVITGAAGGIGLETSILFAKEGANVLMTDISQEALDKALAKVKQLVPNAGRLETKRCDVSKEADVQASVEHLDSWGGLDVIFNNAGIMHARDDDALNTPEEIWDLTHNINVKGVWFGCKHAVLALRRNKKARGSIINTASVVALVGSATPQLAYTASKGAVLALTRELAIVHAREGFRFNSLCPAPLNTPLLQDWLGDDAAKRHRREVHFPTGRFGEAIEQAQAVVFLASDESSFVNGSDFVVDGGMSKAYVTPEGPAAAAPVNNALKDSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3S3</accession>
    <name>Q2H3S3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_06692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222787.1">
        <property type="nucleotide sequence ID" value="XM_001222786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3S3"/>
    <dbReference type="GeneID" id="4391198"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06692"/>
    <dbReference type="HOGENOM" id="CLU_2670857_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3S3"/>
    <dbReference type="OrthoDB" id="10288163at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ90073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="75" mass="8536" checksum="BBEB08C40F1CA7DC" modified="2006-03-21" version="1">MPDGRQFKLRVHATQIWGSMGLGIFSLIAATEKFAQHSTPFRCKLRAFWTGRVVATGMNQTTCSIKRRGHIPYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3U7</accession>
    <name>Q2H3U7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222763.1">
        <property type="nucleotide sequence ID" value="XM_001222762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3U7"/>
    <dbReference type="GeneID" id="4391478"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06668"/>
    <dbReference type="HOGENOM" id="CLU_647224_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3U7"/>
    <dbReference type="OrthoDB" id="4586534at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="424" mass="46262" checksum="D2621AE08695EA74" modified="2006-03-21" version="1">MGDPARLWERQNGVRVTLAHDVLQRALGTSLTVPTATPILGSPSNDVSPAAGGHTPTPSSTLGSPFAYRGTYGRTTPSSTLPRYEHRTTTASPRPSTLGGSSAPASTIQRYPTRRPSPSGWYSRPPGANDHSTEPSPAAPRPARIATTHHSPSPSRTFRLRPSPVLAARHLRTPPPFRPRPVPALPSQHGSPTSDPFRLRPSPTLPRAFVFTTSNTTAYESDSDRAFARSQLRSRLPPRRVPHTPQRQITGAAQRGWSSGYTGYGHGHGYGGPTYSYGGGDGSIIHFGPHQCSLTGHLGRDMASSPSQVPPPQLWPDFSLSWLNNQIRPRKSEIRRFTEIGIHDSDSDDYRHLSIAVATKAMKEMGQHIVVHSRVNADETEFIGSEAYEEYIRLDNELLRASYKKPVPARTPLILGDDETVLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H445</accession>
    <name>Q2H445_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_06570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222665.1">
        <property type="nucleotide sequence ID" value="XM_001222664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H445"/>
    <dbReference type="GeneID" id="4391238"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06570"/>
    <dbReference type="HOGENOM" id="CLU_1539835_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H445"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="174" mass="19428" checksum="092FBD48AA33D0EC" modified="2006-03-21" version="1">MQDLNASLRPLSDPASQPTLLCCFLTVAMPKSSKADPPVLLLSPAELAHKQAGHAEPSSGISLRKSTTTGTPFRSCSVIRRRLHPSLQRGQCLSECWQTPPELGLSGLKHEVVRHRQLLRVLKSPSYTFLPSPNIKHPPLFQFLFDFFPNYHTIPSNTEPDSRSSILDQVDRHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4X5</accession>
    <name>Q2H4X5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222385.1">
        <property type="nucleotide sequence ID" value="XM_001222384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4X5"/>
    <dbReference type="STRING" id="306901.Q2H4X5"/>
    <dbReference type="GeneID" id="4390649"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06290"/>
    <dbReference type="HOGENOM" id="CLU_2183647_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4X5"/>
    <dbReference type="OMA" id="EIWNGEH"/>
    <dbReference type="OrthoDB" id="14527at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009783">
        <property type="entry name" value="DUF1348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757">
        <property type="entry name" value="SLL0781 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757:SF0">
        <property type="entry name" value="SLL0781 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07080">
        <property type="entry name" value="DUF1348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="109" mass="12783" checksum="4B541EF173A01AE2" modified="2006-03-21" version="1">MASYLTTYPKTDSSSFLNSESGWLTRPPFTPETAYQKVKTGQEIWNGEHLQSIFTYNSTWREGNSLLQGRAEIVRFLAQKWKRQKERRITEDLIAFTDNRVCFLKLLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5Y0</accession>
    <name>Q2H5Y0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_05935</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
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                <person name="Untereiner W.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        </source>
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</entry>
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            <dbReference type="PubMed" id="25720678"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6J1</accession>
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            <taxon>Sordariomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Untereiner W.A."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
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    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="5"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221819.1">
        <property type="nucleotide sequence ID" value="XM_001221818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6J1"/>
    <dbReference type="FunCoup" id="Q2H6J1">
        <property type="interactions" value="543"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H6J1"/>
    <dbReference type="GeneID" id="4390374"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05724"/>
    <dbReference type="eggNOG" id="KOG0225">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029393_5_2_1"/>
    <dbReference type="InParanoid" id="Q2H6J1"/>
    <dbReference type="OMA" id="LGYEMPC"/>
    <dbReference type="OrthoDB" id="10256198at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000013">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="6">
        <location>
            <begin position="86"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ89105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="412" mass="45758" checksum="7E0BA6100D47A37B" modified="2006-03-21" version="1">MFSRAVRISRVAPLRAAPRAQAVSIVARRTVTTNAASAEVDKSSIPQAEEEPFHIKLNDESFETYELDPPPYTLEVTKKQLKDMYRDMVVVRQMEMAADRLYKEKKIRGFCHLSTGQEAVAVGIEHAINKDDDVITSYRCHGFAYMRGGTVRSIIGELLGRREGIAYGKGGSMHMFAKGFYGGNGIVGAQVPVGAGLAFAQKYTDSKKATVILYGDGASNQGQVFEAFNMAKLWKLPALFGCENNKYGMGTSAARSSALTDYYKRGQYIPGLKVNGMDILAVKAAVQYGKQWTEEGNGPLVLEYVTYRYGGHSMSDPGTTYRTREEIQRMRSTNDPIAGLKQHILDWGVAQEDELKTIDKEARSHVNEEVAAAEAMAHPEPTPKILFEDIYVRGTEPQFIRGRTPDEAFYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6J2</accession>
    <name>Q2H6J2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA ligase</fullName>
            <ecNumber evidence="12">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_05723</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="12"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221818.1">
        <property type="nucleotide sequence ID" value="XM_001221817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6J2"/>
    <dbReference type="FunCoup" id="Q2H6J2">
        <property type="interactions" value="629"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H6J2"/>
    <dbReference type="GeneID" id="4390373"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05723"/>
    <dbReference type="eggNOG" id="KOG0967">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005138_4_2_1"/>
    <dbReference type="InParanoid" id="Q2H6J2"/>
    <dbReference type="OMA" id="WIKYKRD"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000004">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000016">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="15">
        <location>
            <begin position="596"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="826"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAQ89104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="862" mass="94879" checksum="B9313AA8B2C1608F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6K1</accession>
    <name>Q2H6K1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitochondrial ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_05714</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221809.1">
        <property type="nucleotide sequence ID" value="XM_001221808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6K1"/>
    <dbReference type="FunCoup" id="Q2H6K1">
        <property type="interactions" value="206"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H6K1"/>
    <dbReference type="GeneID" id="4390529"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05714"/>
    <dbReference type="eggNOG" id="KOG1698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076387_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H6K1"/>
    <dbReference type="OMA" id="VCLNIRQ"/>
    <dbReference type="OrthoDB" id="432645at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.790:FF:000007">
        <property type="entry name" value="Mitochondrial ribosomal protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_bL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="Ribosomal_bL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680:SF9">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ89095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="26828" checksum="9FC25979A1AC5DE1" modified="2006-03-21" version="1">MNVAPLARRPLGCLKASLRRTRQQKSMFTRHMASEAAQTTTTTATKTPPPEHGFFRLTDRKTKTLRSAFAVYPSTTVAGANTLAPPPVNALQALHEAQIKRMDPTGARTALFAKTREAAKVGDVLMVTHRRGGEPFAGVCLSIRRRGIDTAILLRNHLAKVGVEMWFKIYNKNVAGIEVVKRQRKRARRARLTYMRKPKHDFGSVEDLVFAWKRSRKVFSTGKPAAGAAKAKAKGKGAAAKKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6N9</accession>
    <name>CAF17_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Iron-sulfur cluster assembly factor IBA57 homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CAF17</name>
        <name type="ORF">CHGG_05676</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GcvT family. CAF17/IBA57 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221771.1">
        <property type="nucleotide sequence ID" value="XM_001221770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6N9"/>
    <dbReference type="SMR" id="Q2H6N9"/>
    <dbReference type="FunCoup" id="Q2H6N9">
        <property type="interactions" value="239"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H6N9"/>
    <dbReference type="GeneID" id="4390748"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05676"/>
    <dbReference type="eggNOG" id="KOG2929">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_7_0_1"/>
    <dbReference type="InParanoid" id="Q2H6N9"/>
    <dbReference type="OMA" id="NMLVAND"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057460">
        <property type="entry name" value="CAF17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25455">
        <property type="entry name" value="Beta-barrel_CAF17_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000301696" description="Iron-sulfur cluster assembly factor IBA57 homolog, mitochondrial">
        <location>
            <begin position="15"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P47158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="437" mass="46753" checksum="BD84262CA8BAF6A4" modified="2006-03-21" version="1" precursor="true">MQPARRVVTSTVRLRARGGVSGVFTCRGCLTRPRLPLPASAPQQRRGLSGSAPRNAAPPGLYPAGIAELSSRKLISVSGPDAAKYLQGVITANLTPGYAGPNPTSEHLRSDAGFYAAFLTAQGRILHDVFIYRDVRDTTHPAGHSWLVEVDAAEADRLQKHIKRYKLRAKFDVRLLNEGEGRVWHAWDDANPSSLTTTQPSFPSSSPTIITTPDHRAPNLGHRLLTFSTPTPSLPLPTLPETAYRLRRYRHGIAEGQAELLYNTALPHESNLDATGAVDFRKGCYVGQELTIRTEHRGVVRKRVLPCVLYPDGQAEGGGVVVVPGEVGFRSDVGAEGVTAEMVPAEASIGRVGKKGRSAGKWLSGVGNLGLALCRLEIMTDVVLPGETGGTGFVEGDEFVVGLGGGSGEEGGEGKKVRIKAFVPDWLRTALASKEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6U7</accession>
    <name>Q2H6U7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221713.1">
        <property type="nucleotide sequence ID" value="XM_001221712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6U7"/>
    <dbReference type="GeneID" id="4390321"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05618"/>
    <dbReference type="eggNOG" id="ENOG502RS60">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_637773_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6U7"/>
    <dbReference type="OMA" id="EPCDYPQ"/>
    <dbReference type="OrthoDB" id="3561626at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209313" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="42361" checksum="629E1FB8426AB610" modified="2006-03-21" version="1">MRAVFSILALAATALTANIPHRGDRGLVGRTYGHGSGGGGGGGGYSGGGGGGHGGGGGGGGYNGGGGKGGGGKGGKDDDCETITTKVIVTYTTVCPVTETHTKPGHTYTTTYTTTSTVKTTVPTTIVITKTAPPVTKSTDQVVYTTLTELCPVTETKVVDGSTVEITWTSTSTVVTKVQQTETIYTTSVATEYETTDVYTTVTCPVTTYTTVIEGSTVKVTQTDTITLTNTDVHTVTDIVPVTITEHVPVTVNVPVTEQETVTGYSTVIVEATETVWTSTPLPPTTIIIPTMVTVPGSGGPGPSSPGTVPGGPGPSSPGGPGPSSPGTSPGSPGPSPSPSPSSPGTAPSSPSTLPGGPGTLPGGPRPSSYGGTPEPTPEPTPEPTPTPTPTPTNGSGTPIPTAGADSLLVARGGKGVALLAGLVAAVVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7H6</accession>
    <name>Q2H7H6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_05389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221484.1">
        <property type="nucleotide sequence ID" value="XM_001221483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7H6"/>
    <dbReference type="GeneID" id="4389992"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05389"/>
    <dbReference type="HOGENOM" id="CLU_762902_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7H6"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ88770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="363" mass="40567" checksum="C1CEB94E73AC3FCD" modified="2006-03-21" version="1">MPYLGTYIYMYLLYMYFPAVCEAPLRGTSVISYCFVNGLGNAEGPPVSVPLLSDQAHLQPTVLGTADHDENWGRDANSFQGDQLALIKLALLGDDELQGDPQHLRAVRQELSKIAATGFDGATVLAEYMRRMWVCAKTKIQSDVADRLKGQSSKLMTAGFTFGIPATWGERAAERMEKAIADSKITDGATFSDLILEPEAAGLAEFPHLDLGVGAFAPLPALSRRSDPSPTVSWIWTQQIPLARAANPLRHDRPLYRDQWQWNQDVGSCQTPITLPFAAFQARTDRDQPCIPIYSCEREVNGCRSIVKDIKVYKNPCQIRCMRPDQLGGSQSLQLRPRLNARQEIEFEVQADLEWMFKVEKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7H8</accession>
    <name>Q2H7H8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221482.1">
        <property type="nucleotide sequence ID" value="XM_001221481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7H8"/>
    <dbReference type="STRING" id="306901.Q2H7H8"/>
    <dbReference type="GeneID" id="4390002"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05387"/>
    <dbReference type="eggNOG" id="ENOG502T4C8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_439404_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7H8"/>
    <dbReference type="OMA" id="QTGHPQI"/>
    <dbReference type="OrthoDB" id="4590776at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="622" mass="67800" checksum="EF1880B96538D5BB" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7I5</accession>
    <name>Q2H7I5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221475.1">
        <property type="nucleotide sequence ID" value="XM_001221474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7I5"/>
    <dbReference type="GeneID" id="4390037"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05380"/>
    <dbReference type="eggNOG" id="ENOG502S808">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001248_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7I5"/>
    <dbReference type="OrthoDB" id="5095382at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="63"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="676" mass="75244" checksum="19D82D65D49EAA65" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7T6</accession>
    <name>Q2H7T6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221374.1">
        <property type="nucleotide sequence ID" value="XM_001221373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7T6"/>
    <dbReference type="GeneID" id="4391362"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05279"/>
    <dbReference type="eggNOG" id="ENOG502S0B1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019613_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H7T6"/>
    <dbReference type="OMA" id="CTHAYPH"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099:SF7">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="49711" checksum="670B4F59F4575271" modified="2006-03-21" version="1">MESAPSETANSKITSLLETVSHALADQADLSVFALGGKINLSTVTEALSNASETSSLVIRWDSGDTNHCRKVSLPVVESDADSQAAFAKLLEDSEPATYGVGSEAVLDETYRKAGKMNAARFSTNFNPYEHGVIDAIAQALTHSDHRGIKAELYNLNLAVRHGGREVMFDWASETASAVQWGAFFSDCEHEVLEVTGGHRLTLAYNLYWTPFGPASMADGLNILEPESLHFFGAIRELLQCPDFLPKGGLLGFTCTHSYPHTSDSSTTTLQHTLKGLDMLVYQALKRFTSSVKVTHALDDHLFQDEWEGYLDDKRDRTATGATQPSYASLATIGTSIRGPIALDGLGDGYPDPEELHYTDYSGGDYYGADYSCDHIDRTGDMAFTRDHVTWLNHHPQKTTPRELAVAFLVYGNEPGINVYYSTAVIVADFRKSSTPEVNEAIESNEPTEATEAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7Y4</accession>
    <name>Q2H7Y4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_03670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230186.1">
        <property type="nucleotide sequence ID" value="XM_001230185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7Y4"/>
    <dbReference type="STRING" id="306901.Q2H7Y4"/>
    <dbReference type="GeneID" id="4388390"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03670"/>
    <dbReference type="eggNOG" id="ENOG502QVGN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_10_1_1"/>
    <dbReference type="InParanoid" id="Q2H7Y4"/>
    <dbReference type="OMA" id="QPDEIWS"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF17">
        <property type="entry name" value="OXIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="44"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ91735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="471" mass="51217" checksum="C013D6D8772B3F33" modified="2006-03-21" version="1">MGTAHSALQQCIEGVGNGRTDFAGFPSSPVTYQSFWVRPYNLDISVNPAGVVRPQTASEVSGIIKCAAAHNVKVQARSGGHSYGNYGIGGADGALVIDLVNFQQFSMDNSTWQATVGAGTRLGQMSENLHNAGGRAITHAVCPGVGVGGHATIGGLGPTSRMWGSTLDHVVEVEVVTADGEIRRANSSQNSDLFWALRGAASGFGVITEFVFKTHPEPGDIVQYEYNVKFGNPAEIAPFYSKWQDMIADPELDRRLGTIFIMLPFGAIITGDFYGTKEELKATGILDMFPQPSESTLVVKSWLGALANSAQKENLYLSDLPVPFYSKSIGFKREDLPTADKIQDLFQWVNDQDKGTVAWAIIFDATGGAVGDVPTNATSFVHRDKILYYQSYAVGLPLSQKSKDFITNFHNEVVGKCSPKAYGTYPGYVDPKLLSAQQQYWESNLPRLREVKKIWDPTDLFHNPQSVKGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8G3</accession>
    <name>Q2H8G3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_03491</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230007.1">
        <property type="nucleotide sequence ID" value="XM_001230006.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H8G3"/>
    <dbReference type="GeneID" id="4388947"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03491"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_0_12_1"/>
    <dbReference type="InParanoid" id="Q2H8G3"/>
    <dbReference type="OMA" id="LFDFWSH"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.980:FF:000001">
        <property type="entry name" value="Non-ribosomal peptide synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="1957"/>
            <end position="2031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ91556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="2499" mass="271561" checksum="BF5AE72F2475DAA7" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9K1</accession>
    <name>Q2H9K1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_03103</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229619.1">
        <property type="nucleotide sequence ID" value="XM_001229618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9K1"/>
    <dbReference type="STRING" id="306901.Q2H9K1"/>
    <dbReference type="GeneID" id="4388958"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03103"/>
    <dbReference type="eggNOG" id="KOG1285">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_281043_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9K1"/>
    <dbReference type="OrthoDB" id="407010at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF24">
        <property type="entry name" value="CAROTENOID ISOMEROOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="19"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="59"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="384"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="767"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="816"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="886"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="1109"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ91168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1116" mass="121482" checksum="517CE218D4B94AB6" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9N3</accession>
    <name>Q2H9N3_CHAGB</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CHGG_03071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001229586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9N3"/>
    <dbReference type="GeneID" id="4388788"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03071"/>
    <dbReference type="eggNOG" id="ENOG502T36D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_990451_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9N3"/>
    <dbReference type="OrthoDB" id="5151015at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="281" mass="30571" checksum="5526B37F5AAB3363" modified="2006-03-21" version="1">MAKVIDNVVRLTSSSPAAKSPDSDVSPGTKVSSIPADYFSPESRTNGDFGRNGLSRPFVSVSTDASTITLASISEEGHLESSRQSSNDSSRPSVGHRKSSTASVTFQQPRNPSLPQGHPRKTDNRRLRESSPSPVRPHGSLVLAPHVVPARYAFCVRGKCQTGAGGRYWENMDGRPSTHRRIPVHSHPGRAAHGKSMQRFSIFPACARPTHGRGAPDLRVQSGCMKKNGTEGPHRHITAMQSERREAWLSFSRELQVHHGKQAKPSLADNQSSELSTPQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HA23</accession>
    <name>Q2HA23_CHAGB</name>
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        <recommendedName>
            <fullName evidence="2">Pinin/SDK/MemA protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229447.1">
        <property type="nucleotide sequence ID" value="XM_001229446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HA23"/>
    <dbReference type="STRING" id="306901.Q2HA23"/>
    <dbReference type="GeneID" id="4388406"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02931"/>
    <dbReference type="eggNOG" id="KOG3756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049352_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HA23"/>
    <dbReference type="OMA" id="MHRRHEK"/>
    <dbReference type="OrthoDB" id="330772at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pinin/SDK/MemA protein" evidence="2">
        <location>
            <begin position="106"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ90996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="310" mass="35357" checksum="E666265305CE8DB3" modified="2006-03-21" version="1">MAETEHYSANKRKASPEVNTEDAIGKRMRLEDGDANTPPSNGVKAEAEDILDGHAPTRNERNGSIIEGSPTRTRRGDREPESRRSPEARRPSATAGPPVRRNVSLEEKKRGQRLFGGLVSTLSRTASSTQQQRRLEIERRQHEKAQQRRAEDEKRRAEKLEQLKRVRQIEQVKLDERAYYVPWEPTKEQEDIISDQVHAVQEAIDRERRDFKTRREQRLRALGVTPSPRSPSPPPREQPRHRPEREEDSGPKAGSHPEEATVGEPNPPPQDTNPGALAPTPPKARDSHPDKDHDEHGDEMMQDKEDIVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAC6</accession>
    <name>Q2HAC6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_02828</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229344.1">
        <property type="nucleotide sequence ID" value="XM_001229343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAC6"/>
    <dbReference type="STRING" id="306901.Q2HAC6"/>
    <dbReference type="GeneID" id="4388505"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02828"/>
    <dbReference type="eggNOG" id="KOG2538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015257_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HAC6"/>
    <dbReference type="OMA" id="YCLMEHY"/>
    <dbReference type="OrthoDB" id="10265211at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20704">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020795">
        <property type="entry name" value="ORC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045667">
        <property type="entry name" value="ORC3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040855">
        <property type="entry name" value="ORC_WH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07034">
        <property type="entry name" value="ORC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18137">
        <property type="entry name" value="WHD_ORC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 N-terminal" evidence="7">
        <location>
            <begin position="62"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 winged helix C-terminal" evidence="8">
        <location>
            <begin position="606"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010977"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ90893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="887" mass="98152" checksum="3D1A62C794ADF7CD" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HB11</accession>
    <name>Q2HB11_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Presequence protease, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Pitrilysin metalloproteinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CHGG_02593</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running. Preferentially cleaves the N-terminal side of paired basic amino acid residues. Also degrades other unstructured peptides. May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer and homodimer; homodimerization is induced by binding of the substrate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M16 family. PreP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229109.1">
        <property type="nucleotide sequence ID" value="XM_001229108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HB11"/>
    <dbReference type="FunCoup" id="Q2HB11">
        <property type="interactions" value="600"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HB11"/>
    <dbReference type="GeneID" id="4389922"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02593"/>
    <dbReference type="eggNOG" id="KOG2019">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009165_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HB11"/>
    <dbReference type="OMA" id="NYLYYIR"/>
    <dbReference type="OrthoDB" id="10250783at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000013">
        <property type="entry name" value="Mitochondrial presequence protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000009">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000011">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055130">
        <property type="entry name" value="PreP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF13">
        <property type="entry name" value="PRESEQUENCE PROTEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22516">
        <property type="entry name" value="PreP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16C associated" evidence="16">
        <location>
            <begin position="463"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAQ90658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="986" mass="109672" checksum="20869056A2EFFCAD" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBB3</accession>
    <name>Q2HBB3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_02491</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229007.1">
        <property type="nucleotide sequence ID" value="XM_001229006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBB3"/>
    <dbReference type="FunCoup" id="Q2HBB3">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="GeneID" id="4389354"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02491"/>
    <dbReference type="eggNOG" id="KOG4472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024327_4_3_1"/>
    <dbReference type="InParanoid" id="Q2HBB3"/>
    <dbReference type="OMA" id="WCFFLYQ"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF7">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ90556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="366" mass="42949" checksum="B8AF9E22C696320F" modified="2006-03-21" version="1">MAIARPVRALGLTAVVLWCFFVWQLFRPIAAPAGPGANSFLPKERDPNLDPTGEPEGVLTYASGERCAISRGHGTTNSTTRGHFSTTYRFSEEFKKKTQAETKAECRYELIPKEHWDVPSWINNDLFLESTKILKEQEVQYADKVSYHQMCRWNSGLFYKHPALANTQYYWRVEPNVHFFCDVDYDVFRYMQDNNKTYGFTINLYDSPESIPTLWPETEKFIAEHPEHVHENNAMNWLTDSKRRPEHNRKANGYSTCHFWSNFEIADMNFWRSKPYEDYFNHLDRAGGFFYERWGDAPVHSIALGLLEDKNRIHWFRDIGYQHIPFFNCPNSPKCKGCVTGRFTDGEAWLHREDCRPNWFQFVGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBM2</accession>
    <name>Q2HBM2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_02382</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228898.1">
        <property type="nucleotide sequence ID" value="XM_001228897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBM2"/>
    <dbReference type="STRING" id="306901.Q2HBM2"/>
    <dbReference type="GeneID" id="4388845"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02382"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_23_2_1"/>
    <dbReference type="InParanoid" id="Q2HBM2"/>
    <dbReference type="OMA" id="CVECALV"/>
    <dbReference type="OrthoDB" id="5244787at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
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        <location>
            <begin position="194"/>
            <end position="320"/>
        </location>
    </feature>
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        <location>
            <begin position="596"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1197"/>
            <end position="1219"/>
        </location>
    </feature>
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        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ90447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1236" mass="138042" checksum="F134109FB57C9863" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCJ4</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">CHGG_02060</name>
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        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    <dbReference type="HOGENOM" id="CLU_2589542_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCJ4"/>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ93825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="80" mass="8763" checksum="5E40BCEA5D9BE36F" modified="2006-03-21" version="1">MPKHMPTTRIELVTLSLRVTRSTPEPCGPKLACLFAELKFQVCKSYPLLVPFVRTGVTVPAARGHAKGSLEELAGCSIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HD62</accession>
    <name>Q2HD62_CHAGB</name>
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        </submittedName>
    </protein>
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    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:coenzyme A catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CoAse"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="767"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="937"/>
        </location>
    </feature>
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        <location>
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            <end position="1020"/>
        </location>
    </feature>
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            <end position="1113"/>
        </location>
    </feature>
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        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
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        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
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        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="452"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
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            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
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            <end position="809"/>
        </location>
    </feature>
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        <location>
            <begin position="814"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="826"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="998"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1085"/>
            <end position="1113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ93607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1113" mass="120855" checksum="E1AED65F63334691" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDM4</accession>
    <name>Q2HDM4_CHAGB</name>
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        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
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        </recommendedName>
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            <fullName evidence="10">Type III PIP kinase</fullName>
        </alternativeName>
    </protein>
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        <name evidence="17" type="ORF">CHGG_01680</name>
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        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57923"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.150"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.1.150" evidence="2"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220901.1">
        <property type="nucleotide sequence ID" value="XM_001220900.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2HDM4">
        <property type="interactions" value="728"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HDM4"/>
    <dbReference type="GeneID" id="4387765"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01680"/>
    <dbReference type="eggNOG" id="KOG0230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000480_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HDM4"/>
    <dbReference type="OMA" id="QSVWNDT"/>
    <dbReference type="OrthoDB" id="158357at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Fab1_TCP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PIPKc_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.810.10:FF:000001">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase FAB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000007">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000283">
        <property type="entry name" value="1-phosphatidylinositol-3-phosphate 5-kinase (Fab1)"/>
        <property type="match status" value="1"/>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDS5</accession>
    <name>Q2HDS5_CHAGB</name>
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            <fullName evidence="8">Peroxisomal ATPase PEX6</fullName>
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        <alternativeName>
            <fullName evidence="9">Peroxin-6</fullName>
        </alternativeName>
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        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
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            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
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    <comment type="subunit">
        <text evidence="11">Interacts with PEX1; forming the PEX1-PEX6 AAA ATPase complex, which is composed of a heterohexamer formed by a trimer of PEX1-PEX6 dimers.</text>
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    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1336"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1379"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="1410"/>
            <end position="1421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ93394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1421" mass="152049" checksum="E43E58FECC852041" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDT1</accession>
    <name>Q2HDT1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_01623</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220844.1">
        <property type="nucleotide sequence ID" value="XM_001220843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDT1"/>
    <dbReference type="STRING" id="306901.Q2HDT1"/>
    <dbReference type="GeneID" id="4387093"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01623"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_17_2_1"/>
    <dbReference type="InParanoid" id="Q2HDT1"/>
    <dbReference type="OMA" id="TYFPEYV"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="630"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="659"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="740"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="77"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="335"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="621"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="790"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ93388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1032" mass="112921" checksum="7AF11BB10ACE6D5B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDW7</accession>
    <name>Q2HDW7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220808.1">
        <property type="nucleotide sequence ID" value="XM_001220807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDW7"/>
    <dbReference type="STRING" id="306901.Q2HDW7"/>
    <dbReference type="GeneID" id="4386287"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01587"/>
    <dbReference type="eggNOG" id="KOG0440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038321_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HDW7"/>
    <dbReference type="OMA" id="EDWVANI"/>
    <dbReference type="OrthoDB" id="10261121at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="349" mass="38301" checksum="956F8E648AF906B8" modified="2006-03-21" version="1">MSNLFSGINARFRGQRSPNSPGTSSPTPEHQSLPQAQAQAPPQAQAQTHSPATPTQGHQGHQGSHSSSSNLAVKLPPLPTSPSLAETIGMDQASGMVPSAEDVLASYHLPQAKPLWLNANYAKHIVKGNFLTLSAKPKTVEMGEWIAHQGIGDSSGVLKHAANRPRQRRRWLFDLQLEEMFQDVSGRIPAYEYLTLVQRYISGKIDDGTIFPTDPAGVSYADNLAFCTPAPESGQDWVGKRSGFPQNFMETCQTIFRQMFRVYAHLYWSHFDDMFSLNLEKSMNSCFSHFILTATTLNLLKKSDLEPMQPLIDLWAALGTFPQGSKAFEIANLQVGQLLVQKAGGPPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HE34</accession>
    <name>Q2HE34_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_01520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220741.1">
        <property type="nucleotide sequence ID" value="XM_001220740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HE34"/>
    <dbReference type="GeneID" id="4386208"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01520"/>
    <dbReference type="eggNOG" id="ENOG502RR30">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196968_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HE34"/>
    <dbReference type="OMA" id="NKAQKCD"/>
    <dbReference type="OrthoDB" id="5170782at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ93285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="83" mass="9344" checksum="09652016221DE565" modified="2006-03-21" version="1">MGRSYQKNPSTTSNTPVQWKDQIRHKYCGALDHGREGKPNKVHRCEACLAVKARQSKFRDGPGDIKLGRKQKMNLKFGGGEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HE75</accession>
    <name>Q2HE75_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_01479</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220700.1">
        <property type="nucleotide sequence ID" value="XM_001220699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HE75"/>
    <dbReference type="GeneID" id="4386190"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01479"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_9_3_1"/>
    <dbReference type="InParanoid" id="Q2HE75"/>
    <dbReference type="OMA" id="IYDIAFW"/>
    <dbReference type="OrthoDB" id="5325318at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF4">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="40"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="428"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ93244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="653" mass="73496" checksum="EBC187B6F85B42E6" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HE83</accession>
    <name>Q2HE83_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_01471</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220692.1">
        <property type="nucleotide sequence ID" value="XM_001220691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HE83"/>
    <dbReference type="STRING" id="306901.Q2HE83"/>
    <dbReference type="GeneID" id="4388201"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01471"/>
    <dbReference type="eggNOG" id="KOG0598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_327879_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HE83"/>
    <dbReference type="OrthoDB" id="1278353at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="56"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="8">
        <location>
            <begin position="348"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="398"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="751"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="753"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ93236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="877" mass="97674" checksum="E3A974B6FC7DD7B4" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEP3</accession>
    <name>Q2HEP3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Efflux pump dotC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Dothistromin biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_01311</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Efflux pump; part of the gene cluster that mediates the biosynthesis of dothistromin (DOTH), a polyketide toxin very similar in structure to the aflatoxin precursor, versicolorin B. One function of dotC may be to transport early-stage dothistromin biosynthetic intermediates from the cytoplasm into vacuoles, thereby affecting the rate of dothistromin production.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="178"/>
            <end position="199"/>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <end position="327"/>
        </location>
    </feature>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
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        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
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            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="556"/>
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            <begin position="88"/>
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            <begin position="1"/>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="648" mass="68895" checksum="5711ACD59465F88A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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        </location>
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            <begin position="1"/>
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        </location>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF25545"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ92844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="303" mass="33376" checksum="D686DFB7AB89B555" modified="2006-03-21" version="1">MGKTGKTTDDATTLGASTIDTEELGPVRQDGNVQGAGNEATVIDYMGGPMKKDHSEGYRQAFNRAFTNLPGDLGFNNGLSAPQPDFVEGLEAEEYRPLPVDDRTPGTAVFRDEPRSITLPQIAGEWEGPAGDTREARMQSAYNGAAMVHARNQALAYMGKADPAGHAEVSTFTTDGDSLNLFAHYAAETEDGMLEYHQYPISSINLTHTYQGHKDGRKSFRNAQDHAREQSYALRDQLKEHYKQQRRGTLRPTDETVPPLPILDVESWARAQTYANEDGYEVVEPQAVYQLTLPTSSTHKHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFF8</accession>
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            <taxon>Sordariomycetes</taxon>
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        </lineage>
    </organism>
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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    </dbReference>
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        <property type="entry name" value="Pericyclase_pydY-like"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ92811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="21953" checksum="EEAF45A722F2163B" modified="2006-03-21" version="1">MAAPTTKTIADLNGKWTMNKTLSSDVGPGLALQGISWMTRKLVNMATLTLEVKQFEGPPSPAEQPTEGVTSCTHIEIEQTGTAGMKGSTEKRCLDFAFREHKDWLFGHVKGQTKFVKAEEVTDAFLKEGWLDGEEEKTGPEGALHVLSYVESMTDGWTATQIWGFQIVEGVRRHVRHVVIAKGAERVELKLVYDYLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFJ3</accession>
    <name>Q2HFJ3_CHAGB</name>
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        <recommendedName>
            <fullName evidence="5">Anaphase-promoting complex subunit CDC26</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">CHGG_01011</name>
    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
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        <property type="nucleotide sequence ID" value="XM_001220231.1"/>
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    <dbReference type="AlphaFoldDB" id="Q2HFJ3"/>
    <dbReference type="GeneID" id="4388048"/>
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    <dbReference type="eggNOG" id="ENOG502R9KK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1209695_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HFJ3"/>
    <dbReference type="OrthoDB" id="4590083at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018860">
        <property type="entry name" value="APC_suCDC26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10471">
        <property type="entry name" value="ANAPC_CDC26"/>
        <property type="match status" value="1"/>
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    </evidence>
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</entry>
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                <person name="Untereiner W.A."/>
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        </source>
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    </dbReference>
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            <end position="208"/>
        </location>
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    <sequence length="726" mass="79450" checksum="36FC47B2827175C7" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
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                <person name="Untereiner W.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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        <subcellularLocation>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00042096"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00808"/>
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    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ92582.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG39</accession>
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            <taxon>Sordariomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG39"/>
    <dbReference type="GeneID" id="4386257"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00815"/>
    <dbReference type="HOGENOM" id="CLU_1532360_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HG39"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ92580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="175" mass="19400" checksum="16103EB41F13D867" modified="2006-03-21" version="1">MAPNMTRGCHLRFPSCLGNDPSYLPCLVDVPDNELVGLIRRTPQNPAAAVQAGGLEITPASVVGCLQAGKYLQRVFSAHAESIKRLTWSHAQALSHRMPFKMRSRRSEPDCELADDATAETARFLALGQRRETRSMRVTTTRISRGDWILTEQTALKCQAYSRLVPNLPVPSQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG68</accession>
    <name>Q2HG68_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_00786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220007.1">
        <property type="nucleotide sequence ID" value="XM_001220006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG68"/>
    <dbReference type="GeneID" id="4386885"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00786"/>
    <dbReference type="HOGENOM" id="CLU_2589540_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HG68"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ92551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="80" mass="9055" checksum="44956477D5D26152" modified="2006-03-21" version="1">MSWHRMGQQWLASLRPASRTQQAAPARDKFGNVGEERFWCPCLNFFFLSKAASVLFLSGHRLLCATGQGWISKIARLGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGC5</accession>
    <name>Q2HGC5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219950.1">
        <property type="nucleotide sequence ID" value="XM_001219949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGC5"/>
    <dbReference type="STRING" id="306901.Q2HGC5"/>
    <dbReference type="GeneID" id="4386765"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00729"/>
    <dbReference type="eggNOG" id="KOG1337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044629_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGC5"/>
    <dbReference type="OMA" id="AWYRSRC"/>
    <dbReference type="OrthoDB" id="441812at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF76">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="23"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ92494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="510" mass="55572" checksum="3DE8D62932F52DB1" modified="2006-03-21" version="1">MYRPTLSIQSLPAWAHLNDVSFHNIKVINTEDKGYGVVSDEDLKATSQANDTSALITVPHGLVLNAAAVEEYAKEDKGFRLLLDAIGHRSTRADVLLFLLVQMVLGSRPSHANVGLSNPWTEYLKFLPETVLVPTLWTEDERLLLRGTSLEAAVDAKISALDAEFDLVREKSSDIIAWNDLLWMEGVPVSFTDWIRLDALYRSRCLELPTSGESMVPCIDMINHSATPSAYYDENTKDEVVLLPRPGVGISKDDEITISYGDAKSAAEMLFSYGFIDPASSAESLVLPLNPFPDDPLAKAKLVAFGEAPKIHVARQGRDKAKEAEEEGGNSNSAKGPVGWTSPFAHLMCVNEEDGLEFRVLQQTDGARQLRVFWQEEDVTDRTGDFEALVRTHPLAAVLRLRVVTVVQGALQAQLERLVSSTVPDAAVAAAATGGAADPAVQQRREDCVRTATVLREIETKILEDAIEGLEGEKNALLADENVVAYLGLTEATESGLAGDEASNEPDDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGD4</accession>
    <name>Q2HGD4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_00720</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the nucleoporin Nup85 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219941.1">
        <property type="nucleotide sequence ID" value="XM_001219940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGD4"/>
    <dbReference type="STRING" id="306901.Q2HGD4"/>
    <dbReference type="GeneID" id="4386761"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00720"/>
    <dbReference type="eggNOG" id="ENOG502SIA5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002336_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HGD4"/>
    <dbReference type="OMA" id="YKPSPAC"/>
    <dbReference type="OrthoDB" id="5422384at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011502">
        <property type="entry name" value="Nucleoporin_Nup85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373">
        <property type="entry name" value="FROUNT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373:SF21">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07575">
        <property type="entry name" value="Nucleopor_Nup85"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="200"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ92485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1206" mass="129647" checksum="ED41F7CE5D6C7D57" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGV4</accession>
    <name>Q2HGV4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_00550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219771.1">
        <property type="nucleotide sequence ID" value="XM_001219770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGV4"/>
    <dbReference type="STRING" id="306901.Q2HGV4"/>
    <dbReference type="GeneID" id="4387969"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00550"/>
    <dbReference type="eggNOG" id="ENOG502SEJJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_17_2_1"/>
    <dbReference type="InParanoid" id="Q2HGV4"/>
    <dbReference type="OMA" id="QPRVTCY"/>
    <dbReference type="OrthoDB" id="5390at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06185">
        <property type="entry name" value="PDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.20">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052353">
        <property type="entry name" value="Benzoxazolinone_Detox_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30212">
        <property type="entry name" value="PROTEIN YIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30212:SF2">
        <property type="entry name" value="PROTEIN YIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00409">
        <property type="entry name" value="PHDIOXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="4">
        <location>
            <begin position="48"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="5">
        <location>
            <begin position="268"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="449"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ92315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="58919" checksum="D40A2963BA5CAFAD" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH05</accession>
    <name>Q2HH05_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAM1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219720.1">
        <property type="nucleotide sequence ID" value="XM_001219719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH05"/>
    <dbReference type="STRING" id="306901.Q2HH05"/>
    <dbReference type="GeneID" id="4387924"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00499"/>
    <dbReference type="eggNOG" id="ENOG502SIPH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013290_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HH05"/>
    <dbReference type="OMA" id="PRYEDDT"/>
    <dbReference type="OrthoDB" id="5407957at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF4">
        <property type="entry name" value="DUF5923 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAM1-like N-terminal" evidence="1">
        <location>
            <begin position="28"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="HAM1-like N-terminal" evidence="1">
        <location>
            <begin position="242"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="745" mass="84985" checksum="07CAF3F5E474C4BE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH07</accession>
    <name>Q2HH07_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_00497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219718.1">
        <property type="nucleotide sequence ID" value="XM_001219717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH07"/>
    <dbReference type="GeneID" id="4387922"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00497"/>
    <dbReference type="HOGENOM" id="CLU_1875198_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HH07"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ92262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="136" mass="14906" checksum="16922991BFA0810B" modified="2006-03-21" version="1">MDPKFRADLQRRERGNDQKAKLISWPHADLETHCRKLLVILVRGKVTALVSEAVPLVRPPLERCGVEMVLGLGGRERWDPAGNFLERPDSQMLCAKYLGGAANGPMDIEAMPATSSVRPAGVLRLAQRAEDCGGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH51</accession>
    <name>Q2HH51_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 19">Autophagy-related protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CHGG_00453</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(out)</text>
            <dbReference type="Rhea" id="RHEA:67920"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 19">Preautophagosomal structure membrane</location>
            <topology evidence="3 19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">Belongs to the ATG9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219674.1">
        <property type="nucleotide sequence ID" value="XM_001219673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH51"/>
    <dbReference type="FunCoup" id="Q2HH51">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HH51"/>
    <dbReference type="GeneID" id="4387545"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00453"/>
    <dbReference type="eggNOG" id="KOG2173">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006200_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HH51"/>
    <dbReference type="OMA" id="MMHYFFR"/>
    <dbReference type="OrthoDB" id="2020634at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007241">
        <property type="entry name" value="Autophagy-rel_prot_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038">
        <property type="entry name" value="APG9 AUTOPHAGY 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038:SF10">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04109">
        <property type="entry name" value="ATG9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 19" id="KW-0072">Autophagy</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 19" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 19" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="589"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="649"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="710"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="602"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="719"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU364027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EAQ92218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="765" mass="87104" checksum="682BF891638D23B2" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHT4</accession>
    <name>Q2HHT4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219441.1">
        <property type="nucleotide sequence ID" value="XM_001219440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHT4"/>
    <dbReference type="SMR" id="Q2HHT4"/>
    <dbReference type="STRING" id="306901.Q2HHT4"/>
    <dbReference type="GeneID" id="4387235"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00220"/>
    <dbReference type="eggNOG" id="ENOG502S46I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_44_8_1"/>
    <dbReference type="InParanoid" id="Q2HHT4"/>
    <dbReference type="OMA" id="SICTGSW"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03139">
        <property type="entry name" value="GATase1_PfpI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF15">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="20"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="200" mass="21733" checksum="0D6A61D41D1E585B" modified="2006-03-21" version="1">MVPAMPGGPVMDLGYMLQPKLVATHSFSDAPALDVLLVPGGFGPVTLEQNNDTSIETFLRRRFDQLEYLLSVCTGSAILASSGLLNGHRATSNKALWSWVTTHGENVTWVPSARWTEDGKIWTSSGVASDAAGIDMMYAFLKHLYGEDDPNLVATMNAIEYTPHTDPHWDPFSIVHDVPGHANGNLESCVKPVGTHSRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHZ1</accession>
    <name>Q2HHZ1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219384.1">
        <property type="nucleotide sequence ID" value="XM_001219383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHZ1"/>
    <dbReference type="GeneID" id="4387224"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00163"/>
    <dbReference type="HOGENOM" id="CLU_2775727_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHZ1"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="69" mass="7172" checksum="5F68BA1C1800654B" modified="2006-03-21" version="1">MSARGRDEGNSRTGSVPPKGRGVTTGIAPHKISPSGWLPSLTRLSKALFDGDWRGVQEGIKVGAIGAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI25</accession>
    <name>Q2HI25_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11 12">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4 11 12">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_00129</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11 12">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4 11 12"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219350.1">
        <property type="nucleotide sequence ID" value="XM_001219349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HI25"/>
    <dbReference type="GeneID" id="4387952"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00129"/>
    <dbReference type="eggNOG" id="ENOG502SMP5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052631_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HI25"/>
    <dbReference type="OMA" id="YSFWSEG"/>
    <dbReference type="OrthoDB" id="2115822at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018208">
        <property type="entry name" value="GH11_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF2">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00776">
        <property type="entry name" value="GH11_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11 12" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209278" description="Endo-1,4-beta-xylanase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="14">
        <location>
            <begin position="27"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ91894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="221" mass="23967" checksum="3D5B25E3E676D47C" modified="2006-03-21" version="1">MVKFSLLAASLVAPSVLAGPLPGPQTQTENALNPRQGGYYFQNWSEGGSNIRCNNGNGGSYTANWNSKGGFVCGKGWSYGGNRAIKYTGTYNATGPGYMAVYGWTRNPLIEYYIIEAHADLAPNEPWTSKGNFSSAEGDYEIFTSTRVNKPSIEGTRTFQQYWSVRKEQRVGGTVTTQNHFNEWAKLGMRLGNHDYVIMATEGYTANGGPGSSGSAAITLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GLZ6</accession>
    <name>Q2GLZ6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_11060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408038">
        <property type="protein sequence ID" value="EAQ82884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230236.1">
        <property type="nucleotide sequence ID" value="XM_001230235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GLZ6"/>
    <dbReference type="STRING" id="306901.Q2GLZ6"/>
    <dbReference type="GeneID" id="4397367"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_11060"/>
    <dbReference type="eggNOG" id="ENOG502S52G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_818902_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GLZ6"/>
    <dbReference type="OMA" id="DTHEHTV"/>
    <dbReference type="OrthoDB" id="2014058at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008699">
        <property type="entry name" value="NDUFB8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE ASHI SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05821">
        <property type="entry name" value="NDUF_B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ82884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="339" mass="38385" checksum="A3B8C0412FE42DFF" modified="2006-03-21" version="1">MLSRHIVRASPFRAAALPAARRLPLIQQRTFLPESMVGRKKMDEKYPDSDYPKLTAAEDPDMNGGFINPPRIKRQFRDPHADWWDKQERRNFGEPVHEDHDILGIFSTWEYTWVSPGKGLFQIGVFVAAFLAVCYGVKLTYADRKSYPREFEGGLERELGGAGAMRVDAEFTKTGELERLRFPHFRRELLFQNHWRPGDDIGRIKIVISEGFPRDSLSAPIERVKNVVAFSFQHAPLEILENNAIAWPNQSMWQCAAFNPAVPVPAYHLDDGPSSHAHSPRRKPAPLRHLKNQGFSGPALTNVVFPGHAGGLLDDSALQMSYLDDNVDTHEHTVSRPVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM28</accession>
    <name>Q2GM28_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226243.1">
        <property type="nucleotide sequence ID" value="XM_001226242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GM28"/>
    <dbReference type="STRING" id="306901.Q2GM28"/>
    <dbReference type="GeneID" id="4397267"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10976"/>
    <dbReference type="eggNOG" id="ENOG502SQFB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_674387_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GM28"/>
    <dbReference type="OMA" id="MWANETY"/>
    <dbReference type="OrthoDB" id="4585870at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="408" mass="45443" checksum="8659301EB7D2111A" modified="2006-03-21" version="1">MAFPTLASAMTGYVARTAAYVKDAPGSDGNYILFNEFDVVAYVIHDAWRINKTGDLLVSYGPTSWDPITGKEAPLLSEDGGIPSNKCGANVSWPGCELFVDTSHYVTEYGFYGLTQEPSVWAGKTQLRAPALNITAFFLGNEVHPTMAGRDWVHPITKEKPFLDPAKVTYMVSNRTYNLSYVQQYGACQPDSDVYQWGFSYIQLFILLVLLLAWTLGIWAIWLKAHINLPLASNKHAGEVPRGRIALLHLAFAMQRDLSVAGIDPTPMTDGQLGREIHQRVKGGGMVWLASADGLDTDPLDGTITTAITDTRKPDVLLGGFLWQKTKELKWVLLAFISYFSATVYGATCLYALAWPLFVVSWLCCFGLYGFFFAGRMRWLLWVYVPCTCILGTVVTFMARRALFMKSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM34</accession>
    <name>Q2GM34_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_10970</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ZNF598/HEL2 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226237.1">
        <property type="nucleotide sequence ID" value="XM_001226236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GM34"/>
    <dbReference type="FunCoup" id="Q2GM34">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GM34"/>
    <dbReference type="GeneID" id="4397237"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10970"/>
    <dbReference type="eggNOG" id="KOG2231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008515_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GM34"/>
    <dbReference type="OMA" id="VFTHEHT"/>
    <dbReference type="OrthoDB" id="3838338at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16615">
        <property type="entry name" value="RING-HC_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057634">
        <property type="entry name" value="PAH_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041888">
        <property type="entry name" value="RING-HC_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056437">
        <property type="entry name" value="Znf-C2H2_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23202">
        <property type="entry name" value="PAH_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23230">
        <property type="entry name" value="zf-C2H2_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="99"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="392"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="567"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="589"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="613"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="685"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="739"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00035113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ83152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="801" mass="84780" checksum="FC02CAE0E6CAC0D3" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM96</accession>
    <name>Q2GM96_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10908</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ83090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GM96"/>
    <dbReference type="GeneID" id="4397145"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10908"/>
    <dbReference type="HOGENOM" id="CLU_182415_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GM96"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ83090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="98" mass="10253" checksum="2FAC0AAD6FC84BF6" modified="2006-03-21" version="1">MEAKEFTTTSYSFKCLKCVPNTNASPVTVRQRNVHAAPVWFALAVFYGAIIRELPTDSTASGLGGRLGGATAGLDRRGVAAIAATGGGLRQSLILSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GML1</accession>
    <name>Q2GML1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ82975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226060.1">
        <property type="nucleotide sequence ID" value="XM_001226059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GML1"/>
    <dbReference type="GeneID" id="4397174"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10793"/>
    <dbReference type="HOGENOM" id="CLU_2145585_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GML1"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ82975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="112" mass="12530" checksum="91EF46F18AA8B054" modified="2006-03-21" version="1">MERDLSDELRPLTRGKENRVLTMLQGDAYGEHGAMPGHTRAQSLEEDVEDRRSKTILDAPESFHVGQLSQQIAYLMPVLPKVFARQQQSRPYLVAGDHAPYCRVDGLIVGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN24</accession>
    <name>Q2GN24_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228557.1">
        <property type="nucleotide sequence ID" value="XM_001228556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN24"/>
    <dbReference type="GeneID" id="4396426"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10630"/>
    <dbReference type="eggNOG" id="ENOG502STSG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156724_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GN24"/>
    <dbReference type="OMA" id="KRACSYN"/>
    <dbReference type="OrthoDB" id="5394791at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208405" evidence="1">
        <location>
            <begin position="20"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="122" mass="13042" checksum="CB434CB683C5DC68" modified="2006-03-21" version="1">MRLTLALTLLTATLGVANPTPDTDATTSPHEVSIPMEVRDVLTPNADAPLHLEKRACRKTGCKCVKGLRQGQYCGACKWKGSYVITAKRNLKHVYECSSNGACCDYGTGSDCNTGSGRCGPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNW6</accession>
    <name>Q2GNW6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_10338</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228265.1">
        <property type="nucleotide sequence ID" value="XM_001228264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNW6"/>
    <dbReference type="STRING" id="306901.Q2GNW6"/>
    <dbReference type="GeneID" id="4396503"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10338"/>
    <dbReference type="eggNOG" id="ENOG502RZG9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_375515_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNW6"/>
    <dbReference type="OrthoDB" id="10248252at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF2">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G04300)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="620"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="700"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="707"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ83934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="739" mass="81399" checksum="908195A6A870EB13" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GP04</accession>
    <name>Q2GP04_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228227.1">
        <property type="nucleotide sequence ID" value="XM_001228226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GP04"/>
    <dbReference type="GeneID" id="4396312"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10300"/>
    <dbReference type="HOGENOM" id="CLU_2573671_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GP04"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="81" mass="8610" checksum="D61942E5ADA0A4A3" modified="2006-03-21" version="1">MEKESAKRRGAPWSRRGQRAGAMGALETGPTESGGSEFMVAPSTRRRRTLTSPTSLGASIVKLSTLDLRITAVAACHRKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQE6</accession>
    <name>Q2GQE6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227735.1">
        <property type="nucleotide sequence ID" value="XM_001227734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQE6"/>
    <dbReference type="GeneID" id="4395998"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09808"/>
    <dbReference type="HOGENOM" id="CLU_1895960_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQE6"/>
    <dbReference type="OrthoDB" id="4559433at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="134" mass="14408" checksum="E0D891DFE559F0E0" modified="2006-03-21" version="1">MASSSAFNNYIVDSAMGPTCSRQVPPGSFGVPAARGHGTTRLHTSYKGPGSRQRASHLPPNPRTNTTTATTSQVQNVHHRLQHLSAAAAARPTSSTFQKCEYAQLKGHICPDFQISEDPSRSKTYDLLACMAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQK7</accession>
    <name>Q2GQK7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,3-beta-D-glucan-UDP glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_09747</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227674.1">
        <property type="nucleotide sequence ID" value="XM_001227673.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2GQK7">
        <property type="interactions" value="475"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GQK7"/>
    <dbReference type="GeneID" id="4396896"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09747"/>
    <dbReference type="eggNOG" id="KOG0916">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000844_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GQK7"/>
    <dbReference type="OMA" id="AWTDFFI"/>
    <dbReference type="OrthoDB" id="1880850at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056261">
        <property type="entry name" value="FKS1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23605">
        <property type="entry name" value="FKS1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="613"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="674"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="738"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1239"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1291"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1408"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1497"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1539"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1575"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1606"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1732"/>
            <end position="1756"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="13">
        <location>
            <begin position="345"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="145"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1778"/>
            <end position="1825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1788"/>
            <end position="1816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ83343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1825" mass="208371" checksum="76CC812A11031FE4" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQV3</accession>
    <name>Q2GQV3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_09651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227578.1">
        <property type="nucleotide sequence ID" value="XM_001227577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQV3"/>
    <dbReference type="GeneID" id="4396418"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09651"/>
    <dbReference type="HOGENOM" id="CLU_3279405_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQV3"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ83247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="41" mass="4288" checksum="AB814882EB582FFF" modified="2006-03-21" version="1">MGTSVILPAEWQGRLATIGSPSLLDVNQATFMAQLSELAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQV4</accession>
    <name>Q2GQV4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Right handed beta helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227577.1">
        <property type="nucleotide sequence ID" value="XM_001227576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQV4"/>
    <dbReference type="GeneID" id="4396417"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09650"/>
    <dbReference type="eggNOG" id="ENOG502R351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041546_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQV4"/>
    <dbReference type="OrthoDB" id="5576103at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="39579" checksum="949267D75DBC5EED" modified="2006-03-21" version="1">MTKSRLFWIYRMPSSPSSNSDVSAPTGPSSEPRRVMSGGSTCPGPMRLRIARRHPGNSFTAKKGSSNVYSGSDYRAAIQAALDSISSGQRVAVMASGSIGASTLTISSGKIFEGCGTINVGNKSGRGAIESTDTTNVQIPYLTMTGNPYFGLRFSGTSGLSLGKITMNLSGGLGIRFDPDRAANSNVKMDVISVTGAGSHAVEVWNIDGLEINQVIARNVGESGLLLQATRNAHVRLVDGNNVATGTGYATFRMANNNGQNANGNYNTNVYIDKVVSRGGGRGIFCVSQSGGVVIEEIDLADNGNNSILIENCYNLSIRGGKVNGGGEVRISARSEFPNTRDIWITLQVDGTSVRESPCADNSNWTLSGNGQRNIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRY7</accession>
    <name>Q2GRY7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_09267</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227194.1">
        <property type="nucleotide sequence ID" value="XM_001227193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRY7"/>
    <dbReference type="GeneID" id="4395415"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09267"/>
    <dbReference type="eggNOG" id="ENOG502SKHG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021916_2_1_1"/>
    <dbReference type="InParanoid" id="Q2GRY7"/>
    <dbReference type="OrthoDB" id="5386330at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ85253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="53668" checksum="BC02A450A3E0F1D7" modified="2006-03-21" version="1">MGEKPETPKRHCWECLRRCVVCDSTRPACNRCAAAGSVCPGYGDVKPTRLVWLAPGKVKSRVRRRKGSPASSADPAELRGHTHPVAAPHAYPKHTVYESIPRFGVNTDADAMVHAAEYCKFYPLQIIPAFTKTLSLSESSGTTPEYIGYRRPSFRSRFLALITCDWGCFVLPQLQQGASLNWRPHVEGAIKLIQLRGGFAALADFKTLEPQLLFLCFMAVLGNTTCPASDLSMTPAHLAALDVILKSTLAPFQMCPAPLFGEIIRINHLRLRATQPTTHPNPKPKPDQLTHEAHQIHSRIRAFSPSHWAGTKPRAREDWTLAGRIYHAAVALYWASALQSAGVLAPTAALRAECAEHARLLQSLLARGVVSPRIWLCTLWPLVVLGVQAAVIGDGDGGGGHDDGGGDGCGEGVGVMPLRDFVAAQLPVLARQGGTYAPLVAKGVLERFWASGETRWDACFDRPYAFVMQIAVDVSRITSPPSQGPAPPPRAVPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GS36</accession>
    <name>Q2GS36_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227145.1">
        <property type="nucleotide sequence ID" value="XM_001227144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GS36"/>
    <dbReference type="STRING" id="306901.Q2GS36"/>
    <dbReference type="GeneID" id="4394660"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09218"/>
    <dbReference type="eggNOG" id="ENOG502SNQY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027371_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GS36"/>
    <dbReference type="OMA" id="IAPANHV"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="28604" checksum="FB9796B337496E8C" modified="2006-03-21" version="1">MLGLAASHLDIYGANVSSHALTHRVKAITLLNQALSTRPTSTAEADARFAAIFALAFQASCMPEGMTEFMSMIKGCHVIAKTSLLEYQDSLFKVFTRDGYGNSVRKILGTAPIVLQRKDEDLLSGFLESLRALGPLCTSSLEVRFLASTEHVVKIARVSAAEAFAHFSEHYGLVLHAAPEEYAPFVDPNHYPAQLLLIHFVLIEFAIGYIALGEVGRRFAYREKSCIAWMNQLAANLPERYKKYAEWPMNYVRTELGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSI5</accession>
    <name>Q2GSI5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
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                <person name="Grabherr M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="ph1033 like domains"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
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            <end position="375"/>
        </location>
    </feature>
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        <location>
            <begin position="468"/>
            <end position="496"/>
        </location>
    </feature>
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            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
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        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
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            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
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        <location>
            <begin position="127"/>
            <end position="147"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="207"/>
            <end position="216"/>
        </location>
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            <begin position="232"/>
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    </feature>
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            <begin position="350"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ85055.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="55792" checksum="3628E08C72963482" modified="2006-03-21" version="1">MSLQNQSKQPDRGPIVPTRSPVEKGESTGKRVGSLAPLEPLVLKESALETARKVADRDDTKNGNSSKDTSAFDRDISKLPKTSSFNSHQEASRERTDPTSTSLSTRDQANSRKNPELMGPRPVLSGQGLQITPTKDSGTTRAAANNKHTARSEEASSDDVFARLLNQVPDLKDFLEMSDYYDVEARTRKLTRFRRLKALAAEKLKLEEEERKLRQEEELDMGPPRSTVALFASTASSAAPSATPDLETASLPTPVTPVPSSMGTREIKESAPANGTKRAREEDASQDRQEKAPRLEEPMPPRVKERDDRPRHDDRHREDDRRDERDYRRDSWSRHDDHSFRSSPPRRRHRDEDDYDGRYRPNGYKGDDRHHRDLESRSKYPIHVDLGSKGDSRFFIVKSFNHENVRICMEEGPMTSGPSPDNPRPSFVKVLRWDTRAPFGVQWLSKTSVHFFRIGHLKNAYNEVPARLGRQGTGKRSMGECGSSAAAGDGRNCGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSZ4</accession>
    <name>Q2GSZ4_CHAGB</name>
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        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="8" type="ORF">CHGG_08910</name>
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        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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    <dbReference type="GeneID" id="4395456"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="232"/>
            <end position="266"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ84896.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="912" mass="99706" checksum="09B0E6B98882CB3E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GT21</accession>
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        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001226809.1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08883"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004471_2_3_1"/>
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    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AAA_lid_13"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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        </location>
    </feature>
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    </feature>
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        <location>
            <begin position="958"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="992" mass="112804" checksum="8FB578AF8789C6B3" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GT75</accession>
    <name>Q2GT75_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_08829</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <text evidence="2">Belongs to the major facilitator superfamily.</text>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08829"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_362895_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GT75"/>
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    <dbReference type="OrthoDB" id="4088837at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:siderophore-iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
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        <property type="entry name" value="GLUTATHIONE EXCHANGER 1-RELATED"/>
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    </dbReference>
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            <end position="74"/>
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            <end position="144"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="171"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="200"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="237"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="323"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="368"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="393"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="465"/>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ84815.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="770" mass="83245" checksum="A8F3C71FBE02D7B9" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTA8</accession>
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        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
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                <person name="Untereiner W.A."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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            <end position="107"/>
        </location>
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        <location>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="39497" checksum="F728682D07969882" modified="2006-03-21" version="1">MEGAPTSCGTETQNPRFRLIEDCSKDVGPEPIQGSGGLPPRATGPKGPAKVLSKAQNRSLRIVVGAYKSAPIRCLETEAWVPPLDLYLNKRLADFEGRLQKQALQSGAGPEAERITTGHLITKACNKVYRRFNKRRKTRGRRPRQGPQSPTPTELAASVVAQWVNYKWKIGGKDRGSNTKEVVEYQGGGRTGLAGPVGTQRASQQSTTRQRVLNRSIADEDPPALLFTDKALMRHEGLTKAQSSLLSQARIGDIGLRDYLFRVKVPEVRTPYCECGRGRETVEHLVVWCPDPPSQRPWDGREIRSHRDLQTVLRGVGARSRRFVRKVLGWLMDSGRLLEYSLARRLELETVDGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUX0</accession>
    <name>Q2GUX0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08234</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225890.1">
        <property type="nucleotide sequence ID" value="XM_001225889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUX0"/>
    <dbReference type="STRING" id="306901.Q2GUX0"/>
    <dbReference type="GeneID" id="4393684"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08234"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_711725_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUX0"/>
    <dbReference type="OMA" id="FMMTPTH"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="39318" checksum="1B87AAE1AFA18170" modified="2006-03-21" version="1">MMEFTEAPVLNISLDFGNDAEFEFNNLGAGWPLGSASGSSCASSSFGPHTPTSGRSSPHYSGSFDFGSSFASSTGVVPFDHSPPSSATSTYFPMTPKTSNVSSFVYPVFPTTPSRGQLVFSCDPLSSYAVQLTPSQNMDCSFPVNHLDSHPYMDAPPALGRYDHLSMGASHWAYPDSPISFDQQHSPVGVAQPVQSIKQEFDEDTKTPMTPMTPSITAKKRVLMDQTRHKTMALQQQMQQFSPSRTRTRAKRGKKCGTAAVGDDNFSMGAVEPATKCECPVEGCDKQYRRSEHMKRHIQRMDNLTTHIKLHWAPREHPGSKPRVKYCPAAKLQWEKMVQNQRRGGGGARRKARAGSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV99</accession>
    <name>Q2GV99_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_08105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CENP-W/WIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225761.1">
        <property type="nucleotide sequence ID" value="XM_001225760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV99"/>
    <dbReference type="STRING" id="306901.Q2GV99"/>
    <dbReference type="GeneID" id="4393475"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08105"/>
    <dbReference type="eggNOG" id="ENOG502SEGJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159428_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GV99"/>
    <dbReference type="OMA" id="YILFMQE"/>
    <dbReference type="OrthoDB" id="2543597at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13732">
        <property type="entry name" value="HFD_CENP-W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052484">
        <property type="entry name" value="CENP-W/WIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34832">
        <property type="entry name" value="CENTROMERE PROTEIN W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34832:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ86852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10547" checksum="BAA472AF0D4E254E" modified="2006-03-21" version="1">MAGQKLYPRATVKKIVKAHSNCNVSKNADVMVPLTPTSNASAELLTQRNQMFLDYMLFMQTLMKEAAIEAKQGGERGITARSVKKATVDSLAKFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVC1</accession>
    <name>Q2GVC1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">UDP-N-acetylglucosamine transferase subunit ALG14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Asparagine-linked glycosylation protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ALG14</name>
        <name evidence="12" type="ORF">CHGG_08083</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterodimer with ALG13 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALG14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225739.1">
        <property type="nucleotide sequence ID" value="XM_001225738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVC1"/>
    <dbReference type="STRING" id="306901.Q2GVC1"/>
    <dbReference type="GeneID" id="4394552"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08083"/>
    <dbReference type="eggNOG" id="KOG3339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064541_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GVC1"/>
    <dbReference type="OMA" id="HTHEMLC"/>
    <dbReference type="OrthoDB" id="17098at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154:SF4">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ86830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="293" mass="32749" checksum="5A6BCA098CBC945A" modified="2006-03-21" version="1">MEKFIRDMIEDFGPDRFAFFVYLGLVCIGMISIAGLFLLPWSSITTIITGLVTFVIGPRQETGRRWISRRDPSTPNTTGLPAVYFLYILGSGGHTSEMLETIKRKFVTQTKEHHNYLVTTGDKDSLNRVIKLECLISAASQTTTTARSKLPVPRARRVHQPFWTAPFTCLQTAIHAINALTREPDVRYAERHPGNPFKYPHVIITNGPATGFIVCLVAHLLKLFYLVPRDRLKMVYVESWARCRSLSLTGPPVPVVGRRRHVLRAARGAGPEDPRCRLCRPGCGSPRPAGLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVK7</accession>
    <name>Q2GVK7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HOOK N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_07997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225653.1">
        <property type="nucleotide sequence ID" value="XM_001225652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVK7"/>
    <dbReference type="STRING" id="306901.Q2GVK7"/>
    <dbReference type="GeneID" id="4393285"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07997"/>
    <dbReference type="eggNOG" id="ENOG502RS64">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013811_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GVK7"/>
    <dbReference type="OMA" id="DAKYRKC"/>
    <dbReference type="OrthoDB" id="49395at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22211">
        <property type="entry name" value="HkD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116907">
        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="658"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="185"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="448"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ86744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="789" mass="90240" checksum="DC72D9BE8DAF965D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GW03</accession>
    <name>Q2GW03_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_07851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225507.1">
        <property type="nucleotide sequence ID" value="XM_001225506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GW03"/>
    <dbReference type="STRING" id="306901.Q2GW03"/>
    <dbReference type="GeneID" id="4393702"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07851"/>
    <dbReference type="eggNOG" id="ENOG502SQVK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076634_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GW03"/>
    <dbReference type="OMA" id="CDFDSAR"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ86598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="315" mass="34272" checksum="4B4B52F09FFF83CC" modified="2006-03-21" version="1">MGTGTGNLEPRLEPAVEESFDGAKDRAAPGQKSEGAGHPLLEEKGPETGAATKRVPLALPRVPSLGLPQTITTGHGMLIPQHLEVLGVGGSSYVYKCHGDLAYKVNVTEREVDLMTAAGDCAITPLCHVLAKIDGAWWRRGLIMELATPFDFKLVPAKERMAVKDEMVGLVERLHSSGIGIANGDIKPDNFLRCRGGKLRLCDFDSARLLTDDEVEDWEGGVSDRYLAPSRRYPETHGPPTVVDDNYALAISVWELFTGKDALIDEDMEDALMEGKTVDLDELEDEDVRTFVWKRLRDGGAKVPDPVPAWDGGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GW45</accession>
    <name>Q2GW45_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_07809</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225465.1">
        <property type="nucleotide sequence ID" value="XM_001225464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GW45"/>
    <dbReference type="GeneID" id="4393777"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07809"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="InParanoid" id="Q2GW45"/>
    <dbReference type="OMA" id="NHRATAM"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF302">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="274"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ86556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="478" mass="49554" checksum="026091953931354F" modified="2006-03-21" version="1">MTCTSSYPSSEHIEFPIPKPAMAARNPTIPLTAREAGPESPTPAAAVTLPPISRKKQAAVVSSAFGAIALTIGYNQCFGVFQEYYLSPDQDVLVPSPASQASPPTALLAFVGTLCYGLTWAGGILVNPVISRIEHGIWGPATPASRVWRRRMLRLLTTRTITVSGVLMMSVGFALASILAGGGAGGLVLSPAFSTLLNSLGGRRTLQIYALFNLVAGLPIAWSVPRSRFANIGTPTPNPDPDPTTNTNTNSQPIHVDTSRPSTHLPFPLFTTPTLLLSAAAAFLQAAGAQLPLAFIPSYSVVLGLGASRGASLLAASSAVNAVARVLTGYVGDRWGRQNMLVVTMAVAGSSVLGLWLGSAGGDGGGEGSGLGVGLWVAFVVLYSFAVGGYYALFPALVADVFGIRQYAAVNAFILMVRGLGTMFGSPVGGQLLGAPDEGARAYVSVAYWDGALLMAATVCCAGVRWADAKGKGWRWIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWD9</accession>
    <name>Q2GWD9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">DNA polymerase</fullName>
            <ecNumber evidence="22">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">CHGG_07715</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 22">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="22"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225371.1">
        <property type="nucleotide sequence ID" value="XM_001225370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWD9"/>
    <dbReference type="FunCoup" id="Q2GWD9">
        <property type="interactions" value="678"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GWD9"/>
    <dbReference type="GeneID" id="4393143"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07715"/>
    <dbReference type="eggNOG" id="KOG0969">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000203_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GWD9"/>
    <dbReference type="OMA" id="CNNCRPR"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="1104" mass="124770" checksum="FB4DD6F26C232F20" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWE7</accession>
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        <recommendedName>
            <fullName evidence="10">t-SNARE affecting a late Golgi compartment protein 1</fullName>
        </recommendedName>
    </protein>
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        <name evidence="15" type="ORF">CHGG_07707</name>
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        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Single-pass type IV membrane protein</topology>
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        <text evidence="2">Belongs to the syntaxin family.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="SNARE_NTD_Tlg1p-like"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="14">
        <location>
            <begin position="165"/>
            <end position="227"/>
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    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="110"/>
            <end position="154"/>
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    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="186"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="111"/>
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    <evidence type="ECO:0000256" key="1">
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ86454.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="257" mass="28025" checksum="6EFD3F5B5FF047F5" modified="2006-03-21" version="1">MSSTNEEDPFLQVQQDVLTQLQTARSLFTSYLRIRSLATASTSPELASARSDLESSLTSLADDLADLVESVRAVETNPAQYGLSVPEVGRRKRLVQEVGGEVDDMREELVKVSSSASSGARRGQKGGGGDLPDPSSFAIADGETDGGAGAGGNDYAAEFEREQQVVMMREQDQHLDGVFQTVGNLRRQADDMGRELEEQVEMLQETERVADRVQGRLQTGMGKLNYVLRRTEDKYSGCCIGLLIVVLIILLILLLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWJ6</accession>
    <name>Q2GWJ6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_07658</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225314.1">
        <property type="nucleotide sequence ID" value="XM_001225313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWJ6"/>
    <dbReference type="FunCoup" id="Q2GWJ6">
        <property type="interactions" value="1088"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GWJ6"/>
    <dbReference type="GeneID" id="4393924"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07658"/>
    <dbReference type="eggNOG" id="KOG2636">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027160_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GWJ6"/>
    <dbReference type="OMA" id="GPKAFQK"/>
    <dbReference type="OrthoDB" id="2160351at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021966">
        <property type="entry name" value="SF3a60_bindingd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12108">
        <property type="entry name" value="SF3a60_bindingd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="9">
        <location>
            <begin position="401"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="332"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ86405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="496" mass="57933" checksum="A9CEC53ADC17B73F" modified="2006-03-21" version="1">MLLEDQRYIHEDLERLEQGIADRMSEEPKHIRDRLNRDHEVAQLLDQIQSQSAELLPLYDDKAGLRSKEILQISTGDPFEEFYRQVTGVRDHHARYPNEQAENSEQWYRPQKGGDDQPYIVESMFSGEEAYGRFFDLHNCHDAYLNLPNAKRLGYMQYLEVFDNFQPGYGGVKRVDKLTDPYFKYLGGLMGYLESFMRRTRPLENIDQVLEGWQRDFEAAWEKRELQGWQTDKAVQGGAAERTLSTPEAVWCDACEKEFKNDNVYKGHLKGRKHIKAAELLAQQEDGNTNGNRVDSAQELKERAVAEREFRVKKLTGAMNIEKDDTRVNVERRQGMTERERAQELENLYNMTSGARNREEEEDEQDEGDDKLYNPLKLPLAWDGKPIPFWLYRLHGLGQEFPCEICGNFVYRGRRAFDKHFNETNHITNLKRLGITDTYLFRDITSIAEAVRLWDKIQRDQNRGQIDDGAVVQMEDAEGNVMPEKVYLDLQKQGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWK8</accession>
    <name>Q2GWK8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_07646</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225302.1">
        <property type="nucleotide sequence ID" value="XM_001225301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWK8"/>
    <dbReference type="STRING" id="306901.Q2GWK8"/>
    <dbReference type="GeneID" id="4393871"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07646"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005712_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWK8"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041068">
        <property type="entry name" value="HTH_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050444">
        <property type="entry name" value="Polyketide_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681:SF6">
        <property type="entry name" value="POLYKETIDE SYNTHASE 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681">
        <property type="entry name" value="POLYKETIDE SYNTHASE 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18558">
        <property type="entry name" value="HTH_51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS/mFAS DH" evidence="7">
        <location>
            <begin position="38"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="422"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="4">
        <location>
            <begin position="38"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="4">
        <location>
            <begin position="203"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="369"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="501"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="961"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="503"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="540"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="4">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="4">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ86393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="988" mass="107844" checksum="24C7B6F63CE5FD0E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWU3</accession>
    <name>Q2GWU3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA-intron lyase</fullName>
            <ecNumber evidence="2">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_07561</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.</text>
            <dbReference type="EC" id="4.6.1.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225217.1">
        <property type="nucleotide sequence ID" value="XM_001225216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWU3"/>
    <dbReference type="FunCoup" id="Q2GWU3">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GWU3"/>
    <dbReference type="GeneID" id="4393270"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07561"/>
    <dbReference type="eggNOG" id="KOG4685">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012847_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GWU3"/>
    <dbReference type="OMA" id="MKWERAK"/>
    <dbReference type="OrthoDB" id="10249562at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000007">
        <property type="entry name" value="tRNA-splicing endonuclease subunit Sen2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="6">
        <location>
            <begin position="582"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="189"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="371"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ86308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="710" mass="77373" checksum="029AF0AE46EE73BC" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWV3</accession>
    <name>Q2GWV3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225207.1">
        <property type="nucleotide sequence ID" value="XM_001225206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWV3"/>
    <dbReference type="STRING" id="306901.Q2GWV3"/>
    <dbReference type="GeneID" id="4393272"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07551"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_23_5_1"/>
    <dbReference type="InParanoid" id="Q2GWV3"/>
    <dbReference type="OMA" id="ACEWASS"/>
    <dbReference type="OrthoDB" id="5244787at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="665" mass="73046" checksum="57F12E18A600E2BD" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXI0</accession>
    <name>Q2GXI0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224980.1">
        <property type="nucleotide sequence ID" value="XM_001224979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXI0"/>
    <dbReference type="STRING" id="306901.Q2GXI0"/>
    <dbReference type="GeneID" id="4394078"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07324"/>
    <dbReference type="eggNOG" id="ENOG502QR62">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030508_0_2_1"/>
    <dbReference type="InParanoid" id="Q2GXI0"/>
    <dbReference type="OMA" id="FYRPAVW"/>
    <dbReference type="OrthoDB" id="276515at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09083">
        <property type="entry name" value="EEP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF36">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="261" mass="28960" checksum="60A45ABD00FCDEAB" modified="2006-03-21" version="1">MVGPLPKAVCTVKVITSGQDSPFVCLQEVLHSQLTDIQARLGPSWGRIGQGREDGKEAGEYSSIFFRADHWECDRSRTYWLSPTPEVSSKGWDAAFERVVTIGSFRHKRTGAVVVVMSTHFDHEGEVAREQSAHLLLKLARTWCGEGAFDLSAPVFFGGDFNSTPTGRAYKVLTEPGIGMKDIFNILPADAKYGNEEITFTSFGDDPNQHPARIDFLFVRDLGSLRFLSFSILPNRFDEGVYLSDHRPVVADVEVSVQVAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXX8</accession>
    <name>Q2GXX8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224832.1">
        <property type="nucleotide sequence ID" value="XM_001224831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXX8"/>
    <dbReference type="GeneID" id="4393210"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07176"/>
    <dbReference type="eggNOG" id="ENOG502QTNX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023475_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GXX8"/>
    <dbReference type="OMA" id="HVPYTKR"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000233">
        <property type="entry name" value="Uncharacterized protein 9G6.260"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="191"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="458" mass="50701" checksum="B0DDFF2F7BB746D7" modified="2006-03-21" version="1">MELTRRRGVVSLQDSQSCIPLSDHLKDGDIILLLTPGIAPDVNPSPSDLDNPPSDPFEPLGKALAKHHPWVRHVPYLPRNGITGTHVVHIRLAAAVIFVISGPPRHGQPSQLALAEITKALCETRPQIILTCCNLQELGPLEQSFPTILEVPGFAPPDLEAAADVLFEPRKPSPKASKVQNITIPPKAWAVEVWDDDRELSDILDLWCQCFPETFHLDPYRFRSLLRRDGYAMHYVVRKPGAAQILGFCATYTTYADSGGERLLGSLAALLVHPSYRQQGIGLSLHTHARRQLTKIRGVCRLQLGSTFPRLLYGLPVTHRMRIGFWNSRVADKTALLKLGLWATSVRLGFSSSRIGDNWFDVSHLSFVPCEFAEFDMVLEFVEKESMKKDTMGWYDQYAKLANTMNIQDIVLGLEGGTIIAAALTYVKNTGSPAADDLPWASTIADDVGECQLTGVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYB0</accession>
    <name>Q2GYB0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="2">6.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_07044</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="2"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224700.1">
        <property type="nucleotide sequence ID" value="XM_001224699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYB0"/>
    <dbReference type="FunCoup" id="Q2GYB0">
        <property type="interactions" value="510"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GYB0"/>
    <dbReference type="GeneID" id="4393145"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07044"/>
    <dbReference type="eggNOG" id="KOG0571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014658_2_2_1"/>
    <dbReference type="InParanoid" id="Q2GYB0"/>
    <dbReference type="OMA" id="GIVCAFD"/>
    <dbReference type="OrthoDB" id="409189at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070981">
        <property type="term" value="P:L-asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000031">
        <property type="entry name" value="Asparagine synthase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000050">
        <property type="entry name" value="Asparagine synthetase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF2">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="6 10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="14">
        <location>
            <begin position="2"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="11">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="376"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="13">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ85791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="579" mass="65304" checksum="FD9F1310B5FB1F57" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYP2</accession>
    <name>Q2GYP2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prion-inhibition and propagation HeLo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_06912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224568.1">
        <property type="nucleotide sequence ID" value="XM_001224567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYP2"/>
    <dbReference type="GeneID" id="4394233"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06912"/>
    <dbReference type="eggNOG" id="ENOG502RUYU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_314747_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYP2"/>
    <dbReference type="OMA" id="IFWTFRT"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF2">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prion-inhibition and propagation HeLo" evidence="2">
        <location>
            <begin position="5"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ85659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="960" mass="108916" checksum="CB519E57C5CCF549" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZ76</accession>
    <name>Q2GZ76_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224384.1">
        <property type="nucleotide sequence ID" value="XM_001224383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZ76"/>
    <dbReference type="GeneID" id="4392608"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05170"/>
    <dbReference type="eggNOG" id="ENOG502RW27">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051050_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GZ76"/>
    <dbReference type="OMA" id="DCILLSH"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050114">
        <property type="entry name" value="UPF0173_UPF0282_UlaG_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546:SF7">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546">
        <property type="entry name" value="UPF0173 METAL-DEPENDENT HYDROLASE MJ1163-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="103"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="367" mass="40402" checksum="066F3AB7B18815BE" modified="2006-03-21" version="1">MNSPKPLRQTTQPPLVLNPLKRVPLLQTSTHHPSPEPTLPITHSKHHPQHPQHHPPNTTSDPASASIYFIGTATTLISHPPLRLLTDPNFLHSGSHIHLGPGVHATRLTDPAVPDLASLPPVDALLVSHYHEDHFDREVQRVLGRDVPIVTTRHAKGCLEREGVEGGAFRAVVGVGEWEGVFMPVAEEVSSIDGRVAAVRVTGLPGKHVPPGVVGVANEWLGAVPPTNGWLVELGWTRGEERTEERFETGYRVYISGDTLMVDELKEIPERLRGEKIDLMLVHLGGTTIPGPKMPLLMVTMDGEQGVQLMQLIHPDVTVPIHFDDYDVFCSPLDDFKKEVDAAGLGDKVVYLNRGDEYRFAVRRGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZB2</accession>
    <name>Q2GZB2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11 12">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4 11 12">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_05134</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11 12">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4 11 12"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224348.1">
        <property type="nucleotide sequence ID" value="XM_001224347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZB2"/>
    <dbReference type="GeneID" id="4393109"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05134"/>
    <dbReference type="eggNOG" id="ENOG502RXA7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052631_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZB2"/>
    <dbReference type="OMA" id="VDWTNCG"/>
    <dbReference type="OrthoDB" id="2115822at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.180:FF:000001">
        <property type="entry name" value="Endo-1,4-beta-xylanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018208">
        <property type="entry name" value="GH11_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033119">
        <property type="entry name" value="GH11_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF2">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00776">
        <property type="entry name" value="GH11_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00777">
        <property type="entry name" value="GH11_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11 12" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209141" description="Endo-1,4-beta-xylanase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="14">
        <location>
            <begin position="45"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ88515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="233" mass="25297" checksum="BBF23DB6B45FB700" modified="2006-03-21" version="1">MVSFKSLLVGALGAVGALAFPLNTTELTEAHARGENVTALLMARGGTPSQTGYHGGYYFSFWTDNGGTVNYWNGDNGNYGVNWQNCGNFVGGKGWNPGASRTINYSGQFNPSGNGYLAVYGWTTNPLIEYYIVESFGTYDPSSQAQNLGTTYIDGSNYKIAKTTRYNQPSILGTSTFDQFWSVRQNKRSSGSVNVGAHFSRWAQSGLRLGQHNYQIVATEGYQSSGSSSITVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZG0</accession>
    <name>Q2GZG0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_05086</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224300.1">
        <property type="nucleotide sequence ID" value="XM_001224299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZG0"/>
    <dbReference type="GeneID" id="4392228"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05086"/>
    <dbReference type="eggNOG" id="KOG1121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009123_10_1_1"/>
    <dbReference type="InParanoid" id="Q2GZG0"/>
    <dbReference type="OMA" id="PRVRWHY"/>
    <dbReference type="OrthoDB" id="5245157at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="546"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="421"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ88467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="630" mass="71618" checksum="F9C799777E20A360" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZI0</accession>
    <name>Q2GZI0_CHAGB</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224280.1">
        <property type="nucleotide sequence ID" value="XM_001224279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZI0"/>
    <dbReference type="GeneID" id="4392295"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05066"/>
    <dbReference type="HOGENOM" id="CLU_789885_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZI0"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="351" mass="37609" checksum="B90E27B6F272E79C" modified="2006-03-21" version="1">MARKGKMEDDIYNGPNPLHDESDEVLAGTIVHLAKEPNEAVSQVVADEIMTRLRRLRRLESGKAPETGSVGIDVTRIQESIVDAVVDGVGQGTGRAMEDSEKTDAGGPEGVARGPEGTAGSEKEASTCTSNNGSPVVGFSGGWGRGAPEENHTGAAQQENTAQEEAARSSRQGKLTFARKVDTDLTGDRGDGVEGLGVTTPEAAETLEAEGQDVGMQGAGFRKPTPTTRSGRRSRRQEDGGERCPTACRKIQQRLSSRKGNRGRPRTLGPQGPTAVERAAGTVMRWTGGTVDTNRVVEEAWKARWLKERDGRAITRPADDFDHQQETLFRDFLFTRGVPEVLTPACECGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZM0</accession>
    <name>Q2GZM0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_05026</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224240.1">
        <property type="nucleotide sequence ID" value="XM_001224239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZM0"/>
    <dbReference type="FunCoup" id="Q2GZM0">
        <property type="interactions" value="189"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GZM0"/>
    <dbReference type="GeneID" id="4392427"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05026"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_82_1_1"/>
    <dbReference type="InParanoid" id="Q2GZM0"/>
    <dbReference type="OMA" id="PWKVPRM"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13994">
        <property type="entry name" value="STKc_HAL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000595">
        <property type="entry name" value="Protein kinase, putative (AFU_orthologue AFUA_5G11840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF137">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="381"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="89"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="640"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="226"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="642"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="655"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ88407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="750" mass="81974" checksum="DFACF94D57249EE9" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2025-06-18" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZU7</accession>
    <name>DBP7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent RNA helicase DBP7</fullName>
            <ecNumber>3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DBP7</name>
        <name type="ORF">CHGG_04949</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family. DDX31/DBP7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224163.1">
        <property type="nucleotide sequence ID" value="XM_001224162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZU7"/>
    <dbReference type="SMR" id="Q2GZU7"/>
    <dbReference type="FunCoup" id="Q2GZU7">
        <property type="interactions" value="658"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GZU7"/>
    <dbReference type="GeneID" id="4392137"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04949"/>
    <dbReference type="eggNOG" id="KOG0348">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_26_2_1"/>
    <dbReference type="InParanoid" id="Q2GZU7"/>
    <dbReference type="OMA" id="AVHIKAD"/>
    <dbReference type="OrthoDB" id="422663at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000464">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17949">
        <property type="entry name" value="DEADc_DDX31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000256024" description="ATP-dependent RNA helicase DBP7">
        <location>
            <begin position="1"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="174"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="413"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="642"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="741"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box">
        <location>
            <begin position="309"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="755"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="187"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="806" mass="87023" checksum="BE971C4BC071D7C0" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZV5</accession>
    <name>Q2GZV5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_04941</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224155.1">
        <property type="nucleotide sequence ID" value="XM_001224154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZV5"/>
    <dbReference type="FunCoup" id="Q2GZV5">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="GeneID" id="4392380"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04941"/>
    <dbReference type="eggNOG" id="ENOG502QT05">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036005_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZV5"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000907">
        <property type="term" value="F:sulfonate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044273">
        <property type="term" value="P:sulfur compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="76"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ88322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="287" mass="31075" checksum="7CE048C30E071B3E" modified="2006-03-21" version="1">MAPSAVEVETVTVPDVTTLKLQAAGPYKELAATKYDAEGEAGLKGHKAAKPFEHTEHGKDADPSYPNLLPEGAVTVTNLTPTIGTEVRGIQLSTLTKAGKDELARFVAERKVVAFRDQDFADLPIDEALEYGSYFGRHHIHPTSGAPEGYPEIHLVHRGAGDTSAEAFFAKRTSSVAWHSDVSYEQQPPGTTFLYVLDRPATGGDTLFADAAEAYRRLSPLFQQRLHGLRATHSAVEQAAASLARGGVQRREPVINEHPIVRTHPVTGEKAIYVNPQCAFPFPSIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H023</accession>
    <name>Q2H023_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_04873</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224087.1">
        <property type="nucleotide sequence ID" value="XM_001224086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H023"/>
    <dbReference type="STRING" id="306901.Q2H023"/>
    <dbReference type="GeneID" id="4392454"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04873"/>
    <dbReference type="eggNOG" id="ENOG502QYWX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004083_5_3_1"/>
    <dbReference type="InParanoid" id="Q2H023"/>
    <dbReference type="OMA" id="HNPMHMA"/>
    <dbReference type="OrthoDB" id="2269373at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF45">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ88254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="801" mass="88873" checksum="F8913B440B976BA4" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H170</accession>
    <name>Q2H170_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trichothecene 3-O-acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_04476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223690.1">
        <property type="nucleotide sequence ID" value="XM_001223689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H170"/>
    <dbReference type="STRING" id="306901.Q2H170"/>
    <dbReference type="GeneID" id="4392408"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04476"/>
    <dbReference type="eggNOG" id="ENOG502RS7Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026450_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H170"/>
    <dbReference type="OMA" id="WGKPESV"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF315">
        <property type="entry name" value="ACYLTRANSFERASE EASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ87857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="52026" checksum="8EA3F5D03989331E" modified="2006-03-21" version="1">MATTTVKPSVPVGEEVIHLSALDQQAQRHYAKPLLFFELDHEGPNDPVLEHLKKSLSVALSEAPDFASTVAPLPGSTRKELQLQLNPKSGASWRVFDHTAEVNKGAWSYGSFQELAAKHFSLSDVPTELLVDSTLVDIPEDVQELPALSIQLNLIKGGIILAICWHHTVSDARGFNVLLNSWARHTKESMLRGEPDDAIIPAEEARDRWRLDHGAANATIAQIPEYVVDANARSPRSAASLHLLDREDPLGAPFQISTWYLSSESLQSLRDSLGADGNSGAFTPVEAVSALFWKHISRARGLLDRSEEGATSLFTTRLEFRARLLPPLSGDYIGNICEPNAHARLPLSELCSPATGTSLAKVASAIRAATEAVDDAAVRTYIGLINTLPAVTDLTWNYNGFPGPDFGVTDVSGLDICRTDWGPSLGAPVCLRLAYREGGLLYLFPIDPQGGLEVQALCEPDALEKLKADEGLAKFATFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H185</accession>
    <name>Q2H185_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vesicle-mediated transport protein Vid24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223675.1">
        <property type="nucleotide sequence ID" value="XM_001223674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H185"/>
    <dbReference type="FunCoup" id="Q2H185">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H185"/>
    <dbReference type="GeneID" id="4391708"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04461"/>
    <dbReference type="eggNOG" id="KOG4635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028759_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H185"/>
    <dbReference type="OrthoDB" id="62at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33968" checksum="A8F1325204AA1F6B" modified="2006-03-21" version="1">MSPGPQPDGDSRDVHMRHVPGRTTTTRDGAAEERQKPTDVDEDMRLAAAELSHGGAVGGSGGVASGSRERTRTTACEPPSETKSRAEQLLPIPVETHEADVWGPLDKGPRWVEDSGLMGMGLEYSHMRVMTPAPSLYLQAGSRFVGTQQSKRQRYEVEVEIKHVDMRESFMCGHLTIQGLADDHPTLTTYFEGEIIGSKHGFVTQHQEWGASEKVDFQHWSKFTAFRPYQKQMRKGTQTLIKDLDQRENIFMRWKEHFLVPDHRIRTIRNASFEGFYYVCFNQVKGEISGIYFHRKSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1G4</accession>
    <name>Q2H1G4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">diphthine methyl ester synthase</fullName>
            <ecNumber evidence="4">2.1.1.314</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_04382</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diphthine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="4"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223596.1">
        <property type="nucleotide sequence ID" value="XM_001223595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1G4"/>
    <dbReference type="FunCoup" id="Q2H1G4">
        <property type="interactions" value="834"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H1G4"/>
    <dbReference type="GeneID" id="4393069"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04382"/>
    <dbReference type="eggNOG" id="KOG3123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066040_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H1G4"/>
    <dbReference type="OMA" id="HNASIMS"/>
    <dbReference type="OrthoDB" id="2516at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000004">
        <property type="entry name" value="Putative diphthine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ87763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="250" mass="27695" checksum="2680141A39544C46" modified="2006-03-21" version="1">MLYLVGLGLSDETDITVKGLEVVKKASRVYLEAYTSILLVDQSVLESYYGRSIVVADREMVESNSDEILRDAQNVDVAFLVVGDPFGATTHTDMVLRARELGIQVRTVPNASIMSGIGAAGLQLYNFGQTVSMVLENMARGRKIYEPPRYMSVGTCAQQMLEIEEEKGLGAYGPESLAIGAARVGGKTEKFVAGTLKELCDADEELGPPLHSMVLLGRRTHELEHDFVREFAINKENWDRIWKAEYEGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1H4</accession>
    <name>Q2H1H4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">16 kDa allergen</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223586.1">
        <property type="nucleotide sequence ID" value="XM_001223585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1H4"/>
    <dbReference type="GeneID" id="4392712"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04372"/>
    <dbReference type="eggNOG" id="ENOG502SP7Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144311_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H1H4"/>
    <dbReference type="OMA" id="ANDAGCY"/>
    <dbReference type="OrthoDB" id="3682664at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195:SF4">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208392" description="16 kDa allergen" evidence="1">
        <location>
            <begin position="20"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="16329" checksum="A58346797CBC0B6E" modified="2006-03-21" version="1">MKFFTTALTAALVATGASAQQAVVKNNCQTTVYVQSFPYDGSAAGPLTTLAPGKSFTEDLRQSGSTVKVAKTKTLSTPLFFGYSFSSNPDYAYYELSTQWGNPFADKHNVLTPGDGCEFFDCAANDANCYSKPGASKVYGCPQPVNLELDLCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1M8</accession>
    <name>Q2H1M8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7025 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_04318</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223532.1">
        <property type="nucleotide sequence ID" value="XM_001223531.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4391835"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04318"/>
    <dbReference type="eggNOG" id="ENOG502QQ9D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_249918_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H1M8"/>
    <dbReference type="OrthoDB" id="37730at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19357">
        <property type="entry name" value="TenA_E_At3g16990-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053261">
        <property type="entry name" value="Polyketide-peptide_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41813">
        <property type="entry name" value="REGULATOR PAB1642, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11955)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41813:SF2">
        <property type="entry name" value="REGULATOR PAB1642, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11955)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1561"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1587"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7025" evidence="3">
        <location>
            <begin position="668"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1520"/>
            <end position="1551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ87699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1692" mass="189595" checksum="65F4089255C0024B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-12-16" modified="2025-06-18" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1V7</accession>
    <name>MKAR_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Very-long-chain 3-oxoacyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.1.1.330</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">3-ketoacyl-CoA reductase</fullName>
            <shortName evidence="4">3-ketoreductase</shortName>
            <shortName evidence="4">KAR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Microsomal beta-keto-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">CHGG_04239</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="EC" id="1.1.1.330"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.330" evidence="4"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223453.1">
        <property type="nucleotide sequence ID" value="XM_001223452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1V7"/>
    <dbReference type="SMR" id="Q2H1V7"/>
    <dbReference type="FunCoup" id="Q2H1V7">
        <property type="interactions" value="618"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H1V7"/>
    <dbReference type="GeneID" id="4391738"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04239"/>
    <dbReference type="eggNOG" id="KOG1014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_38_0_1"/>
    <dbReference type="InParanoid" id="Q2H1V7"/>
    <dbReference type="OMA" id="LVAPGMM"/>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045703">
        <property type="term" value="F:ketoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141040">
        <property type="term" value="F:very-long-chain 3-oxoacyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:sphingolipid biosynthetic process"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000317">
        <property type="entry name" value="Very-long-chain 3-oxoacyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03107">
        <property type="entry name" value="3_ketoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027533">
        <property type="entry name" value="3_ketoreductase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000357304" description="Very-long-chain 3-oxoacyl-CoA reductase">
        <location>
            <begin position="1"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Lowers pKa of active site Tyr" evidence="2">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="L0E2Z4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="O93868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P38286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03107"/>
        </source>
    </evidence>
    <sequence length="342" mass="37736" checksum="418462DF062E0E4B" modified="2006-03-21" version="1">MAFNFDAQEILDRALDLWNSIPQAGQWALAGLGALYVAQPVLSFIQLFLNCFILSGTNLRKYGKKGTWAVVTGASDGLGKEFASQLAAKGFNLVLVSRTQSKLDTLARHLELRWSGLQTKTLAMDYSQDNDADYERLAELISGLDIGILVNNVGRSHSIPVPFLETAREELQDIITINCLGTLKTTQVVAPILAKRKKGLILTMGSFAGVMPTPYLATYSGSKAFLQHWSSSLASELKPHGVDVQLVVSYLVTTAMSKIRRTSLLIPNPKQFVSSALSKVGLTGNEMFPNTYTPWWSHAAFKWVIESTVGATSGVTIWFNRKMHVDIRTRALRKAEREAKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H222</accession>
    <name>Q2H222_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_04174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ87555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H222"/>
    <dbReference type="GeneID" id="4392880"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04174"/>
    <dbReference type="HOGENOM" id="CLU_2739803_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H222"/>
    <dbReference type="OrthoDB" id="10365792at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ87555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="71" mass="7794" checksum="BE9116239FC9EDC3" modified="2006-03-21" version="1">MPLRTAPSTAQKTGWWRSGRIKLSVGLDLKAVLVAMATRTAKLLTPTVFKLLKRVLPATPSSVFQRMKGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H223</accession>
    <name>Q2H223_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP synthase subunit K, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_04173</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001223386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H223"/>
    <dbReference type="STRING" id="306901.Q2H223"/>
    <dbReference type="GeneID" id="4392879"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04173"/>
    <dbReference type="eggNOG" id="ENOG502SCBN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172736_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H223"/>
    <dbReference type="OMA" id="RQVGSHY"/>
    <dbReference type="OrthoDB" id="2094445at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021278">
        <property type="entry name" value="ATP19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11022">
        <property type="entry name" value="ATP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ87554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="7440" checksum="4DA45670B36E08A6" modified="2006-03-21" version="1">MVQTYKLFGANVGSHYLAMGVLGTLFVGSYAAMGGSKAKPATPPINASSSDEADFIKCAHIPPAVHMVISLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2H5</accession>
    <name>Q2H2H5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_04021</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223235.1">
        <property type="nucleotide sequence ID" value="XM_001223234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2H5"/>
    <dbReference type="STRING" id="306901.Q2H2H5"/>
    <dbReference type="GeneID" id="4391652"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04021"/>
    <dbReference type="eggNOG" id="KOG1121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_410481_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2H5"/>
    <dbReference type="OrthoDB" id="2639200at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="591"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="592"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ87402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="673" mass="75602" checksum="FA6F3B4E83D21DAA" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H475</accession>
    <name>Q2H475_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MICOS complex subunit mic19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222635.1">
        <property type="nucleotide sequence ID" value="XM_001222634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H475"/>
    <dbReference type="FunCoup" id="Q2H475">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="GeneID" id="4390310"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06540"/>
    <dbReference type="eggNOG" id="ENOG502SDJV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093897_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H475"/>
    <dbReference type="OMA" id="GKSLNCW"/>
    <dbReference type="OrthoDB" id="5544375at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012471">
        <property type="entry name" value="DUF1690"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07956">
        <property type="entry name" value="DUF1690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="19388" checksum="521D329F9B6D7A9B" modified="2006-03-21" version="1">MGSNTSKPSNPAPHVWRGSSQAGVSQSLVESLETSNETDVSRLQALELHIQERVAAELKRLRAQESETLREAQQKLSAGPATDQQGSEHQQQQLAGPSRQEVSKAIGDLRAKLEERKKVRQVPETLEKARDEVVRCLRENDRRPLDCWREVEAFKEEVRRLEKGWVDKVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H588</accession>
    <name>Q2H588_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222272.1">
        <property type="nucleotide sequence ID" value="XM_001222271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H588"/>
    <dbReference type="GeneID" id="4390685"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06177"/>
    <dbReference type="HOGENOM" id="CLU_2096598_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H588"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="116" mass="11933" checksum="A04AF9DEB418F102" modified="2006-03-21" version="1">MTVHPTMASFNNGLCRFGGSFADPDRPRSCESPGVATDGRSVPASQRSSSRSGLAPGVVIDSQARREEVKVRSNPGTGPVIQLSPLGCLGSVPSHPSSRSSGCPATSDIRQEGGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5C7</accession>
    <name>Q2H5C7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_06138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222233.1">
        <property type="nucleotide sequence ID" value="XM_001222232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5C7"/>
    <dbReference type="GeneID" id="4391112"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06138"/>
    <dbReference type="HOGENOM" id="CLU_1758587_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5C7"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="148" mass="16976" checksum="DCEE387C1FA20458" modified="2006-03-21" version="1">MTNLNEGGWYTCVVAEVEETQEIVGYCVWEWYEYDEKYKRIDEAYRPTKVQAIWDLMGAEEPTHRPPRSYGPEAYRDPFLQARWHAEGPGSNYGLSHEALLVTSGSTGFSQFWQIDHVAVDPRSEYSDVWEKLKWASTTGSGSDIGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5D6</accession>
    <name>Q2H5D6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">pectate lyase</fullName>
            <ecNumber evidence="5">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_06129</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="5"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222224.1">
        <property type="nucleotide sequence ID" value="XM_001222223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5D6"/>
    <dbReference type="STRING" id="306901.Q2H5D6"/>
    <dbReference type="GeneID" id="4390381"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06129"/>
    <dbReference type="eggNOG" id="ENOG502S66G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021894_2_1_1"/>
    <dbReference type="InParanoid" id="Q2H5D6"/>
    <dbReference type="OMA" id="FHDHHKA"/>
    <dbReference type="OrthoDB" id="1637350at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000036">
        <property type="entry name" value="Pectate lyase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF18">
        <property type="entry name" value="PECTATE LYASE 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208522" description="pectate lyase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="13">
        <location>
            <begin position="48"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ89510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="317" mass="32760" checksum="B57DF9A6FEDBEA8C" modified="2006-03-21" version="1">MKFLFTATIATLASFVAATPTQVVKRASPEDKCDIGYASINGGTTGGAGGTTTTVSNLSDLTAAVKGDAKKIVLVSGSISGTGSIKVGANTSLLGKSGASITGVGLTIKEANNVIIRNLKLSKVKGGDCVAVQEASNIWLDHLDISGDLSADKDYYDGLLDITHAGDYVTVSNSHFHDHWKASLVGHSDSNAAEDTGKLRVTYANNKWTNINSRTPSIRFGTGHIYNNYFDTITTSGVNTRMGAIVFVESSTFVNAKRAITSIDSDVDGKAAVKDVDLGGSTNDAPAGSLSVPYSYSVVGSANAKSSNANSGATLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5H7</accession>
    <name>Q2H5H7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_06088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222183.1">
        <property type="nucleotide sequence ID" value="XM_001222182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5H7"/>
    <dbReference type="STRING" id="306901.Q2H5H7"/>
    <dbReference type="GeneID" id="4390945"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06088"/>
    <dbReference type="eggNOG" id="ENOG502SC31">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048152_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5H7"/>
    <dbReference type="OrthoDB" id="5318346at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080">
        <property type="entry name" value="SRR1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080:SF1">
        <property type="entry name" value="SRR1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="2">
        <location>
            <begin position="83"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="269" mass="29765" checksum="3A59A3392534EAAD" modified="2006-03-21" version="1">MAGQDGDAGEWNQVKRRGGRLRNIPAPTNEAADSLVDGIRPNTKPELSVNDLWNYHESVTQDSQTTEWWDQVRQLLDSILNKPGCPTITRAVCLGPGPYEPSNGSSIARRTAHMQTAAFCCLVGCLSRGPSDIGTESPIADHHTESQDGRDIHCVVQEPRFTETDKEFCAKLGVEAVESPAGFSLVDESTLLFGIHMELDIYNQAMVIPPAIYVGASLEEWEKVVDGGSETEGPLAAYGKMDKTYDRYPFPDLDYMFSSTVMYWRRAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5M0</accession>
    <name>Q2H5M0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_06045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222140.1">
        <property type="nucleotide sequence ID" value="XM_001222139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5M0"/>
    <dbReference type="GeneID" id="4389948"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06045"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_8_0_1"/>
    <dbReference type="InParanoid" id="Q2H5M0"/>
    <dbReference type="OMA" id="WLCQEKA"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="300" mass="32142" checksum="75D9A4230E04A18C" modified="2006-03-21" version="1">MENLPTDHFVTSLQFTKNVYQDVYPSIDPTKPELSLAGKVVIITGASRGIGARGIAPAFAKAGAKAIVLVATNAEKLAAVEAEIKAINPSVQLLSVATNMADAASVANLFAKVKANFGHADILVNNAGVSNANGVIHEQNIDEWWSNFEVNTKGTFLLAQSFITSLPTPTTPATLINLTTAAAWLVLPFMVGYSTSKLASQQLIAHIAAAYPNITAVSLHPGLVDTDMTHESFRRFDLDTPELVGGVAVWLASERARFLSGRAVAAQWSVDDLVEREREIVEGGLLRMEMKGELGVDQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6A7</accession>
    <name>Q2H6A7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221903.1">
        <property type="nucleotide sequence ID" value="XM_001221902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6A7"/>
    <dbReference type="GeneID" id="4391413"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05808"/>
    <dbReference type="eggNOG" id="ENOG502SDVM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053554_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6A7"/>
    <dbReference type="OMA" id="CISGTNI"/>
    <dbReference type="OrthoDB" id="5222339at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="37566" checksum="B18A68DBC1458F63" modified="2006-03-21" version="1">MAANTTQITSSILDQPVDYRDLKEWIEEQERNPKPLTPHQQRAISDLRRSIEPDIGVRDWVSLMNRYTQAHGGTPAFIDEPAPDERWTYRCIFKPTADTEQMSFPNPEAGFTPNEHGVPAAPSFGRKKDAKQYAAKCCVEWLMKGGYMPSNGTDVEFPKPPKTSRHASNTPTPAPAAKKPRGDNNNNNNHPDAPPNRPKKRAANSDNDDEDDEDDDPPATKRVATLCQLLGLAIPQYKITPAVLLPTPHLSDTDPSSPSTIAAAPLTPSNPQFFDGCADFGADAIKVPEGLGRVSSVYGRRNAREKVAEEVLAWLVAEEGRRMAEVEEMMAQVGESPTEVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6W7</accession>
    <name>Q2H6W7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221693.1">
        <property type="nucleotide sequence ID" value="XM_001221692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6W7"/>
    <dbReference type="STRING" id="306901.Q2H6W7"/>
    <dbReference type="GeneID" id="4390494"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05598"/>
    <dbReference type="eggNOG" id="ENOG502SIP4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072658_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6W7"/>
    <dbReference type="OMA" id="KPYRYIR"/>
    <dbReference type="OrthoDB" id="5358886at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208872" description="NlpC/P60 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="24161" checksum="A1E0506C4E2297E4" modified="2006-03-21" version="1">MQLTSLVLTLAAAISTVAAYPITGNDVNCRSGPDTSYKSVKTYKKGADVKLTCQTYGESINGNAIWDKTSDGCYVSDYYVKTGSNSMVTKECPIAGGGGGSQYNGPINRTEIISRGRYWVSRKVPYSMSKTYPDQQGRKYRTDCSGFWADLKPGDFVGTLGEGTAGAAGHVTLFLSWADSAHKAYNTLECRGTYGCVQYKRNVGWKSGGFTAKPYRYTRVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6Y0</accession>
    <name>Q2H6Y0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221680.1">
        <property type="nucleotide sequence ID" value="XM_001221679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6Y0"/>
    <dbReference type="STRING" id="306901.Q2H6Y0"/>
    <dbReference type="GeneID" id="4390540"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05585"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043434_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6Y0"/>
    <dbReference type="OMA" id="NIREYAM"/>
    <dbReference type="OrthoDB" id="2935572at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12261">
        <property type="entry name" value="RRM1_3_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="38751" checksum="A221CA54764712D5" modified="2006-03-21" version="1">MLLSKDDEAIQGGAKTPMAPKADPNEDGGARLYTPAPPGACSPPKEVPHNGHHNRYQDRSTWADGNVDDDEDDENGASDTESPIEGPLGANYAKPQGQRQHFERQCVRTLQLSHLAEGTTHADIVNAVRGGMLVDIFLRSHDRCAMVSFLRSVDAKEFYDHVRRHDLYIRNKRIEVKWNDRQFVLAGHVANKIGTGASRNLVIQGYDNRHTEEIIREDLDHIHNLVVVKIEFIGRNCHIGLNSVHNAISARQCMLSRLYVSLQPSHRLEADRNNSRYKGKKINYDVDECAQPYPQPAPRARKEMAPLKKGFPAVHNRFQLLNLDDDDDDEIAATFQTKNSVGITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7I6</accession>
    <name>Q2H7I6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_05379</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221474.1">
        <property type="nucleotide sequence ID" value="XM_001221473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7I6"/>
    <dbReference type="STRING" id="306901.Q2H7I6"/>
    <dbReference type="GeneID" id="4390036"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05379"/>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_125_8_1"/>
    <dbReference type="InParanoid" id="Q2H7I6"/>
    <dbReference type="OMA" id="KDYTHEN"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031469">
        <property type="entry name" value="SesB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17046">
        <property type="entry name" value="Ses_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal death-pathway protein SesB" evidence="3">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="2">
        <location>
            <begin position="81"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ88760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="823" mass="92229" checksum="F62DC42DE618DD17" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7N8</accession>
    <name>Q2H7N8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_05327</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221422.1">
        <property type="nucleotide sequence ID" value="XM_001221421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7N8"/>
    <dbReference type="GeneID" id="4390753"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05327"/>
    <dbReference type="eggNOG" id="ENOG502S098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006016_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H7N8"/>
    <dbReference type="OrthoDB" id="4590034at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07491">
        <property type="entry name" value="Peptidases_S8_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="843"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="364"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="675"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="849"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="887"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ88708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1118" mass="125013" checksum="1E237A4C462D566F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7Z9</accession>
    <name>Q2H7Z9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230171.1">
        <property type="nucleotide sequence ID" value="XM_001230170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7Z9"/>
    <dbReference type="GeneID" id="4388506"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03655"/>
    <dbReference type="HOGENOM" id="CLU_1815576_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7Z9"/>
    <dbReference type="OrthoDB" id="10563788at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="142" mass="14910" checksum="081DAC7C7CE21A56" modified="2006-03-21" version="1">MAIPRPSRTCKAVSVPLNAPTMPEKTKGVKGRKSHGKRPAKSKASSPNEKQHLAAMAGQLDTPLPGAVPGTADSDEGVISEGNLGRGDGQNKTTAQIRLDAWNDGLLDGFLNPGTQDGVCEGFTTLHRCISNFARSMTEAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H811</accession>
    <name>Q2H811_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_03643</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230159.1">
        <property type="nucleotide sequence ID" value="XM_001230158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H811"/>
    <dbReference type="GeneID" id="4388889"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03643"/>
    <dbReference type="eggNOG" id="ENOG502QR0G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047601_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H811"/>
    <dbReference type="OMA" id="HQPDPKC"/>
    <dbReference type="OrthoDB" id="10248513at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000039">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.13, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF874">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ91708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="42680" checksum="5CEA4A958AA9741C" modified="2006-03-21" version="1">MLAQELSMDLPVIDLDVFLNQPRDSSAVQAECVKAAEALITYGALVLHDSRVADQDNETFLDLLEDYFAQPEADLRKDERPELAYQIGVTLENTEKPKCAVDEPCLQVIERLAPSERPLDISAHSPDPKCRFFWRMVESPPYTSKFPTLNADNIIPDAPHIRERWEPTMNQWGTSMKNAVEDLTQMTAVGLGLEADTFKEAGRYGSHLLAPTASDLAKYGQVDTILAGFHTDLNFLTIHGRSRYPGLHIWARNTGKRIPVKIPAGGNYLLVQAGKQLEHATGGLVKAGYHEVVVNDATVRAIEDRRARLPDRPLVRISSTFFWHLASDHDLVPIPALAEKARAVRAQQFDLGKDEGEEVQYPPMKVGEQVQSELKHIALMATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8A2</accession>
    <name>Q2H8A2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">laccase</fullName>
            <ecNumber evidence="4">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_03552</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="4"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230068.1">
        <property type="nucleotide sequence ID" value="XM_001230067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8A2"/>
    <dbReference type="GeneID" id="4388402"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03552"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_3_2_1"/>
    <dbReference type="InParanoid" id="Q2H8A2"/>
    <dbReference type="OMA" id="CHIIEHQ"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000046">
        <property type="entry name" value="Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF87">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209345" description="laccase" evidence="10">
        <location>
            <begin position="25"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="13">
        <location>
            <begin position="84"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="190"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="12">
        <location>
            <begin position="413"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ91617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="588" mass="65012" checksum="F41E0444B3AB3166" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8S4</accession>
    <name>Q2H8S4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_03380</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229896.1">
        <property type="nucleotide sequence ID" value="XM_001229895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8S4"/>
    <dbReference type="GeneID" id="4388773"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03380"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011025_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8S4"/>
    <dbReference type="OMA" id="IGYLQCA"/>
    <dbReference type="OrthoDB" id="413885at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.10">
        <property type="entry name" value="Cholesterol Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053208">
        <property type="entry name" value="GMC_Oxidoreductase_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190:SF2">
        <property type="entry name" value="CELLOBIOSE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G17620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="2 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208642" description="CBM1 domain-containing protein" evidence="8">
        <location>
            <begin position="24"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="9">
        <location>
            <begin position="768"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ91445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="804" mass="85564" checksum="6F763220068EDFA4" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8X0</accession>
    <name>Q2H8X0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229850.1">
        <property type="nucleotide sequence ID" value="XM_001229849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8X0"/>
    <dbReference type="GeneID" id="4389637"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03334"/>
    <dbReference type="eggNOG" id="ENOG502RIZ9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_903147_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8X0"/>
    <dbReference type="OMA" id="WESDPAP"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="33201" checksum="C14E8D19BB3A6B6E" modified="2006-03-21" version="1">MYQYNGCPPAAQKAVLSISEMLNPAAPVSHHSARYGAASSPGAWSPSDAAPSPSNYTYSSQPERTGWEYHPSAAAWESDPAPRRYPATPTTRLPPISVPPSEGPAGGYAGDGHRNSHSSWGGGSGASSPRVFGSFTPVEGARQQHLPTGGGLARGERETSLSTLDGSEGPAKASGKTRQNFPGPVTKVFNEWAEKRILVNDDRCRFTKSEMVTIASVTDVELKQVENWYTNHRRRGFPQQMIDVLHREAKAVERKYREADQLAAQQQQEGTATPGEVLRAQAEAVRAAGAPGRSPGSGNRRRGKGWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H918</accession>
    <name>Q2H918_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229802.1">
        <property type="nucleotide sequence ID" value="XM_001229801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H918"/>
    <dbReference type="GeneID" id="4388836"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03286"/>
    <dbReference type="eggNOG" id="ENOG502T94U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1015675_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H918"/>
    <dbReference type="OMA" id="MHTCHES"/>
    <dbReference type="OrthoDB" id="4555925at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209064" description="2EXR domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="5"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="276" mass="32270" checksum="31645E326BACF483" modified="2006-03-21" version="1">MSATFTVFSLLPLELRQLIWHLALPGDEPEVFVIQAAHIDQKAQNAPPEPKTVDTAFPVLMHTCHESRAYVRNHSGIRFRFSIEADCEVPFRPFRPELDTVFWDENRVFHLWGPFYTAAHHRWLWQVRHLAIPSANTYVGQHMTECVFAYCPAVQSLSVVFADSTDYNRLQTTFDEPGRRRKLRNIQLDHAKRMKFVFDPWHADLHHQITLYDFLVLFCDELNHHGGNMDDAHEDCVGWGIQGDSSERRLCLAQTFVQWRRGEWAEVCAQKRLAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H996</accession>
    <name>Q2H996_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like 1-activating enzyme E1A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_03208</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229724.1">
        <property type="nucleotide sequence ID" value="XM_001229723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H996"/>
    <dbReference type="FunCoup" id="Q2H996">
        <property type="interactions" value="1045"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H996"/>
    <dbReference type="GeneID" id="4388361"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03208"/>
    <dbReference type="eggNOG" id="KOG2014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002556_4_1_1"/>
    <dbReference type="InParanoid" id="Q2H996"/>
    <dbReference type="OMA" id="EFFGQFD"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01492">
        <property type="entry name" value="Aos1_SUMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="8">
        <location>
            <begin position="48"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="342"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ91273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="464" mass="48316" checksum="5D1E19BD16A2468A" modified="2006-03-21" version="1">MDHQQAQAPEPAVIFGNQTAATPTMPTDNNGSVPAPGNAISADEIALYDRQIRLWGMKAQEKIRNANILLITMKALANEIAKNLVLAGIGSLTILDPDPVTPSDLGAQFLLSEETTPLGTNRAAAAAAALQRLNPRVRIHIDTVDVRFKPPSFFAPFDIIIATDLDSPTLNIINTATRLHSRPFYAANSHGLYGFLFADLIEHTFVISRAKSNLPTPLGPESRTRSVLAVAPKPGAEATTELVTKRELYSTWYLASGASQLPADILRSPRRRRAVTPLLSCFRAAWEFAANHAGAAPQTADRSHLAEFTRLCSDQHKALGLPSETLRSDVLRAFLQNVAPSSASASVGNGNGGVNGGGDGSGNGGGGGRGGASEVAPVAAVLGGQLAQDVINVLGCTQQPIQNFVVFDGEVMEAGVYALHPEGELGRGLLVSAGPVVGLEEGVGGVDAHGSVLGAGEGGALMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAB8</accession>
    <name>Q2HAB8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type transcription factor MSN2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_02836</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229352.1">
        <property type="nucleotide sequence ID" value="XM_001229351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAB8"/>
    <dbReference type="STRING" id="306901.Q2HAB8"/>
    <dbReference type="GeneID" id="4388866"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02836"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030977_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HAB8"/>
    <dbReference type="OMA" id="PFFYYNP"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000141">
        <property type="entry name" value="C2H2 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000243">
        <property type="entry name" value="Probable transcription factor steA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF13">
        <property type="entry name" value="RESPIRATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0843">Virulence</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="454"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="364"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="554"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="559"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAQ90901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="581" mass="62169" checksum="EFAF3D57D86919AC" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAF3</accession>
    <name>Q2HAF3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_02801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229317.1">
        <property type="nucleotide sequence ID" value="XM_001229316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAF3"/>
    <dbReference type="GeneID" id="4389662"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02801"/>
    <dbReference type="eggNOG" id="KOG1379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029404_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HAF3"/>
    <dbReference type="OMA" id="FKTEGQW"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000118">
        <property type="entry name" value="Phosphatase 2C-like domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF24">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ90866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="417" mass="44642" checksum="FE59F3BB02EB2345" modified="2006-03-21" version="1">MAERRGAAAAETPDIPDNAVVTRPVIINPTHGVVITKGKLDPSVFSNLPFRFDTGIALFAKRTPRPFPPPYLSPPSGSFSDPLSTHDRSRDRRRAYVDGHLIQGYTNGDDAVFASDYFICANDGVGAWSARPRGHAGLWARLILHFWATAVFEDAARQGASYRPDPVGDLQRAYEQTIEATGPPNDWQGTTTVAGAQLHYRRVTKFPTPNNNPANDPDPNEQRNIDTDADAFEPILHVTNLGDSQVMVIRPSTRQTVYKSTEQWHWFDCPRQLGTNSPDTPRGSAVVDEVALREGDVVLAMSDGVIDNLWAHEIVATVCDALERWRAGGGHSAPSAAGAGGDGAVATPGVGLPGDGDDSGMGFVAEELKEAARVIAVDPFAESPFMEHAIEEGLASGGGKLDDISVVAAICKRNGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAG1</accession>
    <name>Q2HAG1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_02793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229309.1">
        <property type="nucleotide sequence ID" value="XM_001229308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAG1"/>
    <dbReference type="FunCoup" id="Q2HAG1">
        <property type="interactions" value="758"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HAG1"/>
    <dbReference type="GeneID" id="4389380"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02793"/>
    <dbReference type="eggNOG" id="KOG3063">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031077_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HAG1"/>
    <dbReference type="OMA" id="FKWKFSS"/>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170071">
        <property type="term" value="C:CROP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030906">
        <property type="term" value="C:retromer, cargo-selective complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140318">
        <property type="term" value="F:protein transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000004">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000010">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ90858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="37422" checksum="966B50F561490043" modified="2006-03-21" version="1">MSYFFATPVDIDIVLDNADERSMVDVKLDKNRREKAPLYMDGESVRGAVTVRPKDGKRLEHTGIKVQFIGTIEMFFDRGNHYEFLSLVQELAAPGELQHPQTFDFNFKNVEKQYESYNGINVKLRYFVRVTVSRRMADVIREKDIWVYSYRIPPEMNSSIKMDVGIEDCLHIEFEYSKSKYHLKDVIVGRIYFLLVRLKIKHMELSIIRRETTGAAPNQYNESETLVRFEIMDGSPSRGETIPIRLFLGGFDLTPTFRDVNKKFSTRYYLSLVLIDEDARRYFKQSEIILYRQAPELANSQDQGALPAPPPENKQIMAGTSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAK0</accession>
    <name>Q2HAK0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229270.1">
        <property type="nucleotide sequence ID" value="XM_001229269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAK0"/>
    <dbReference type="STRING" id="306901.Q2HAK0"/>
    <dbReference type="GeneID" id="4388661"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02754"/>
    <dbReference type="eggNOG" id="KOG0406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_7_2_1"/>
    <dbReference type="InParanoid" id="Q2HAK0"/>
    <dbReference type="OMA" id="WADHINR"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="53985" checksum="762282C17894EB72" modified="2006-03-21" version="1">MLGYLRCSTPQNSMGSQALTRAYLRGAWSALPIPSRAIGTALPPLNQFGTPSQSPAADPAVTGVPRDGSTDLAKADPANGSGSLGLARGGQLPANIVENPPDLHLWRQKLFDLQSPVILTNEEYDMYFPWVDNIYSHRTSQTASKRGLVTRYFDCRLKGRPSGTPKSQDPNKKKRKRTVRPLDLCDVRIKITEYPASSVGELTAICNSIGLNSEQVEAAASRIRDRPFRVIQRNGMIGNGDDRLATHKHDLQKSDETKKSTALRYLAGREKEAKRTQKPPAWKPRGNAAATARDHSGDADIKFYSACFCHGLRVRQYWRDRSSSAMPKPHITLLEARPEQGLSPPDTGQGGWACAESSVILEYLEDTNNTVPLHPTIPKLKANCRLWIDFINTRIVPSFSSVLLATVDEGPYFLGDHMCLVDVHLAPFALRLSRLAPFSGLSLSALPTRWKGWLDALEQNPHVCSTMSTDALYAESIDDLIKGFQRISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCC9</accession>
    <name>Q2HCC9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2'-phosphotransferase</fullName>
            <ecNumber evidence="2">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_02125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="2"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221346.1">
        <property type="nucleotide sequence ID" value="XM_001221345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCC9"/>
    <dbReference type="STRING" id="306901.Q2HCC9"/>
    <dbReference type="GeneID" id="4386379"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02125"/>
    <dbReference type="eggNOG" id="ENOG502RVN8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_852584_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCC9"/>
    <dbReference type="OMA" id="WANCEDI"/>
    <dbReference type="OrthoDB" id="419694at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="296"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ93890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="326" mass="35108" checksum="94F7678559F4E78B" modified="2006-03-21" version="1">MAAAVAVPLSTINGALGGVLPPSALTQHSPRHGRSRAMSMKGKGGRQRGYSVVEERDVTIAKALMFVVKRAIQKEDVEEDEDGEYLVADPEGWISLADVLTHSRISALGATIEDIQRVVGTAAKSRFDLRLVSDTEGNAEEPASWQISRIASKETVTSPTPVGDKLTAESPNIPEFVVYETSYQRYPLILALGAITRAPGASEYRTFVPVTVDNEGNESRQSPAGETAEVSVWVHLRTALQAEPSITWYRSDSGTIITTDNIPKGLWKKAIARRPDLGIVFEDGETRKEIPVNLRGKGAKGRARKGKVVGVKEEGSGDDSGSASEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCJ5</accession>
    <name>Q2HCJ5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221280.1">
        <property type="nucleotide sequence ID" value="XM_001221279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCJ5"/>
    <dbReference type="GeneID" id="4387348"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02059"/>
    <dbReference type="eggNOG" id="ENOG502RAC5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1461141_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCJ5"/>
    <dbReference type="OMA" id="SSHFTRP"/>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="185" mass="19644" checksum="6AF5EAC5F038C6F2" modified="2006-03-21" version="1">MRTLQKITYALPRATAPSNPGLFGTDWSSHFTRPDDPQHRDHHTRASSNSTQIYHGQARPSHRRGIHSVGQDRVTTTPTPPGHIAPNPSPYPNSGPATGAGTGVFVSAQMFGTEVKGNPTESEADVAADRSDLDPLPPGLHHTIRLGAGDAAPLPTESEADVVADRGAADADAEPLWAGEKKRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCS1</accession>
    <name>Q2HCS1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221204.1">
        <property type="nucleotide sequence ID" value="XM_001221203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCS1"/>
    <dbReference type="GeneID" id="4386230"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01983"/>
    <dbReference type="HOGENOM" id="CLU_831546_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCS1"/>
    <dbReference type="OrthoDB" id="10461049at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="334" mass="38113" checksum="C64D658B46750E9F" modified="2006-03-21" version="1">MSDMLAKKKQETRQKIAARRAKVLDTTSRVFWRRDQEWLRRRMNLQQQATFKTLFEKRGYNDPNVGIGIDFIAWNIDYGLWDGLRHSPEDYEALQPIFEEAPRPTDTPWCAQFRDYQRSRLGQKAEKDPLNQANTETKSLKRRSDAEDNKANDLHPQPKKLRQQELKFTTIEPQTSNYPGPYPHRHHRHQQTPPAHVLSQSHAFIYQGFNPRTTRKQIAGAAKHSEGRCTAGHRRRRADGDFFTVRLREAVAATRINQRPGAHPMPCWTGPFGWRCARREEPVTVGVDGEGAGAGVKEGPVTVWLLAVAVADRAEVTSLRGLGHLAETDPVLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCZ7</accession>
    <name>Q2HCZ7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221128.1">
        <property type="nucleotide sequence ID" value="XM_001221127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCZ7"/>
    <dbReference type="STRING" id="306901.Q2HCZ7"/>
    <dbReference type="GeneID" id="4386245"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01907"/>
    <dbReference type="eggNOG" id="ENOG502TCM7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010785_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HCZ7"/>
    <dbReference type="OMA" id="DIEPFHL"/>
    <dbReference type="OrthoDB" id="5244857at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="836" mass="90945" checksum="1D9C2807F3B71D39" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2025-04-09" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDD6</accession>
    <name>MED8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Mediator of RNA polymerase II transcription subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Mediator complex subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MED8</name>
        <name type="ORF">CHGG_01768</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Mediator complex subunit 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220989.1">
        <property type="nucleotide sequence ID" value="XM_001220988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDD6"/>
    <dbReference type="SMR" id="Q2HDD6"/>
    <dbReference type="STRING" id="306901.Q2HDD6"/>
    <dbReference type="GeneID" id="4386751"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01768"/>
    <dbReference type="eggNOG" id="ENOG502S8U1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074399_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HDD6"/>
    <dbReference type="OMA" id="WAPIEAN"/>
    <dbReference type="OrthoDB" id="5329317at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019364">
        <property type="entry name" value="Mediatior_Med8_fun/met"/>
    </dbReference>
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        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074:SF9">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10232">
        <property type="entry name" value="Med8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000304540" description="Mediator of RNA polymerase II transcription subunit 8">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="191"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="180"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="288" mass="31560" checksum="CCA9B516155B8E79" modified="2006-03-21" version="1">MSPEELKQLELLRNRFAQLTSNLGSLRTSVSNSNPLPTYESLQASVNILQANIRSIQDIATENAGLFQRLAIHPSTNFPGRTQEHILTQLLRKKLEPNVESWVEEARATARGVGVDASKLAGGVHRRGEHDYDDEGTYGMDEDGDDAPQDPFSEQWADMLDNFQQTLQQYVTVQVKKKYTAEERAAGIENVRTGLRQTLEESEDDDEDEEEEEEDEEEDEAAAAAGNAGGLATGAGGSAAAGGGMFGAIEPEHIFYLQAQGNLQLPGNVPIESKRIQTVPTRRVAPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDH1</accession>
    <name>Q2HDH1_CHAGB</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CHGG_01733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="4386753"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01733"/>
    <dbReference type="eggNOG" id="ENOG502S91F">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_434738_0_0_1"/>
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    <dbReference type="OMA" id="DMWDSIQ"/>
    <dbReference type="OrthoDB" id="5421421at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="629" mass="68940" checksum="DF998D7C221EA691" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDL2</accession>
    <name>Q2HDL2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01692</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220913.1">
        <property type="nucleotide sequence ID" value="XM_001220912.1"/>
    </dbReference>
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    <dbReference type="STRING" id="306901.Q2HDL2"/>
    <dbReference type="GeneID" id="4387547"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01692"/>
    <dbReference type="HOGENOM" id="CLU_818894_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HDL2"/>
    <dbReference type="OrthoDB" id="4585883at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="36918" checksum="89144364A99F2D52" modified="2006-03-21" version="1">MELINLRNEHTTKVTHGLGLQLAEFGKIDPPTCCSTANEPDGIDNQSSLSSTTDYLDEGNIASIGSYAIEKLPGPGIEATHHRQQLEEAVENFVEELVALKLKAEGTSLHLTSSSTGPQGVGSFGSSSGDSSLKRKTSGGGGGGSRFRRPRKDDDHGDNGDASRRNSGGDGPPGNSKSPDPEKSHPLEFMCPYRLKDPIRFNVREWYDCATKVYICEGSGSKRNELHELRRHIKQRHSGPGILSLHYCSTCKEEFPSPTLLDEHAKQGACVYRELPSSNDPLDGRSPEAERTLRSKQGRQGDSALCQYKKICQIALGDSSDVPSPGKLPPRRCEDSEWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HED8</accession>
    <name>Q2HED8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_01416</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220637.1">
        <property type="nucleotide sequence ID" value="XM_001220636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HED8"/>
    <dbReference type="STRING" id="306901.Q2HED8"/>
    <dbReference type="GeneID" id="4387424"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01416"/>
    <dbReference type="eggNOG" id="KOG3106">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041571_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HED8"/>
    <dbReference type="OMA" id="FIYPRTR"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="209"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ93181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="37264" checksum="214FE06D34E133CF" modified="2006-03-21" version="1">MSHITAKCILIFSIHRNKSSEGVSLLTQLFYALVFVTRYTDLFRESYAWNYFFKVFYLLSSFYTIGIIRFIYPRTREREVAWKLSAIILAACLFLSPFVMLIFDDWWSFQEYLWVFSQVLESVCVLPQLLLLRQTTIPTVITSFYIVFLGSYRGLYLLNWILKELDTNMKKPNPISVIFGVIQTALYLDFAWVSPAILTATAPTTRRVPPALGRNGFNHHQQQNGGNNNGGGGVRPKWGSRGISISADEGVLEHERERGQALDEDDDEDGGVAGAVDPDAKMRDPDELALALDEDEDLDAPGASSASSAQQKKDTHTQPSGVRGGDEWNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEU1</accession>
    <name>Q2HEU1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Allergen Asp f 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220484.1">
        <property type="nucleotide sequence ID" value="XM_001220483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEU1"/>
    <dbReference type="GeneID" id="4386405"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01263"/>
    <dbReference type="eggNOG" id="ENOG502SN6Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043430_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HEU1"/>
    <dbReference type="OMA" id="TTESWNI"/>
    <dbReference type="OrthoDB" id="118256at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019863">
        <property type="term" value="F:IgE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038903">
        <property type="entry name" value="Allergen_Asp_f_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25312">
        <property type="entry name" value="Allergen_Asp_f_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208862" description="Allergen Asp f 4" evidence="2">
        <location>
            <begin position="18"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="30960" checksum="4B4CA87382D73599" modified="2006-03-21" version="1">MQLTHFLLLAGALGAVAHPSGHAHLHRSVQARGNGPAHVKNVHNKPIPKSAAAKVAEPAASVAPSPSPKPKPSEPTESDEFIPFCGGTSSKSKRVTYEQVMYTGNLGTNGGCKWNSNLMLVPNKIAKKYKYVQEYTNVAKEPYQVICGNKMGADKQLTGMFKVEGQEQLIFTLQPGETKTVVADSNTQGVCAFAPNKVELTIHGQYAGVWAEFDFENTSNEGWSGADCSSLVAQAYDLDVPGCRMSEGGVDSTILAGGIGDNAYTKGMEKLDGIGLNIVPGATVIKVYVGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEY2</accession>
    <name>Q2HEY2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_01222</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220443.1">
        <property type="nucleotide sequence ID" value="XM_001220442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEY2"/>
    <dbReference type="STRING" id="306901.Q2HEY2"/>
    <dbReference type="GeneID" id="4388196"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01222"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_498732_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HEY2"/>
    <dbReference type="OrthoDB" id="5296112at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="272"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="428"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ92987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="464" mass="50395" checksum="91C73CE7E96B5267" modified="2006-03-21" version="1">MDVDANAVYAAGDHEPKLPGSTALHILACGVAFWHVEALEYLLSKRPNIEARNKMGLTPLLAAIHGDMPYGPWREETVRVLLRHGADVNAIMETTEDVWGGSSALEMSNHAGITKLLLENGASVKSCPGILTRVIREWMDPEIAKLLLDAGLDPDELPSLQEQTRVDFALQGIVRGPRPGIPRFYDRGIPSELQPREAITGRTLLASACIPMIPMAHVLLNVGADPLIVDDEGRTPLHWLCTFQGPFDVPHRNAFTALTRNGPGALTIRDKQGRTPLHLALATHANVSQHSLFAVQHLLAAGADPAEPDPTTGNSALHSIAPRLLGKSEASAAAATLFRELATRVEALDVFVELGADLQAVDGRRRTLLHAVAEGWDLPGWDVTGLFKRLMELGVDPRAEDEALRTAIDVAVARELRGVVMLFTEEGKMEEAERQVRADNESNSDKSSSDSDSEDEDDLGILWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HF27</accession>
    <name>Q2HF27_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220398.1">
        <property type="nucleotide sequence ID" value="XM_001220397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HF27"/>
    <dbReference type="GeneID" id="4386349"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01177"/>
    <dbReference type="HOGENOM" id="CLU_906136_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HF27"/>
    <dbReference type="OrthoDB" id="10355767at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209210" evidence="2">
        <location>
            <begin position="23"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ92942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="307" mass="32827" checksum="AE0239FDCF73D96F" modified="2006-03-21" version="1">MSAWLACCCSWWMLGSWMLAGKLQENASCRRLRAEEAGDGDLLLGQTGLSTSGHITEFLCSVPSHVPAQNAGLQASSATCGPGGPGQPRPHLGGAGLRTAVFSDQWQSPATHRICVPCQTGEMDVASNVGATPGPGACCPTTPPTFLGMIARIFWVQATVAVVFGNLLSALASPTAELLSDGIPSAEIELLPACRISGNHQQRVPSIDGRLRPNNRAKLGLDRPASERRGPHRGRPLSSVTVRGAPRKTPTDGDLRLIFSSGRRFARIASPDGRCRREPSRELPLSFCSYMYASHSALRTRRTRHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFC0</accession>
    <name>Q2HFC0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_01084</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Endoplasmic reticulum membrane</location>
            <topology evidence="2 10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the OST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220305.1">
        <property type="nucleotide sequence ID" value="XM_001220304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFC0"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="UniPathway" id="UPA00378"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="InterPro" id="IPR007676">
        <property type="entry name" value="Ribophorin_I"/>
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        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1"/>
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    </dbReference>
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        <property type="entry name" value="RIBOPHORIN I"/>
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        <property type="entry name" value="Ribophorin_I"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
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            <begin position="466"/>
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        </location>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="494" mass="55317" checksum="AB2DC7D4313E2300" modified="2006-03-21" version="1">MKTSAVFSALLSLLSLASAASADSKSSSTSTTLPATFKPPQVFKNANLVHVISVEKNYVKENINVLVQNIDKAAQDEYFVPFTADQLSRLGGVEVKDRKDSNAGPFVAEAVEFDQESDIQYLRIRLPKPLAPGAQQTLGISYYLLKAYKPLPASIKQEEPQFLSFSFSAYCPSAYTTTKQKTEVKFPSSTIPDYTKIPGSGEISEFPQVQGSKLTYGPFDEKPTGATQPVSVRFEFNKPVTHVSHLERDIEVSHWGGNVAFEERYTLYHRGANLSSLFNRVKWQQSQYYQPNTFALKELKFPLRVGSADPYYTDVIGNVSTSRFRSNKREALLEVKPRYPVFGGWKYPFTIGWNSDAKNFLRQTAAGGFVLNVPFLEGPRQPEGVEYEQVQVRVILPEGAENVKYHTSVPSQSISQVSVELHRTFLDTLGRTALVIKGRNLVDDFRDRELVITYDYPLVAALRKPLIIFGSAVTVFVGAWLVGNLELKFDTRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFZ0</accession>
    <name>Q2HFZ0_CHAGB</name>
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        <recommendedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
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            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
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        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ92629.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="810" mass="88379" checksum="B6156BD8AB70DD83" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG03</accession>
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        <submittedName>
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        </submittedName>
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        <name evidence="2" type="ORF">CHGG_00851</name>
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    <organism evidence="2 3">
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG03"/>
    <dbReference type="STRING" id="306901.Q2HG03"/>
    <dbReference type="GeneID" id="4388099"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00851"/>
    <dbReference type="eggNOG" id="ENOG502SA5E">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086075_1_0_1"/>
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    <dbReference type="OMA" id="ISEADMF"/>
    <dbReference type="OrthoDB" id="5422320at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF3807"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12720">
        <property type="entry name" value="DUF3807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="195" mass="21966" checksum="CE934D2A1A4D8491" modified="2006-03-21" version="1">MAGTSLKVPQISQAEMIAFHEAHFSRLATDQFQAQFLRPNHPPAEEITYNAADDEEYYEEEDDGLGYYPDGVKRTLTDEQIAIFRHSELEALRRARESSSSGKTTTVKPEEDAAYDMSEDGEVSSALSTTAKQSKKRKRGKSKKNKTTNGGEPIDLRKRTWDVVDKGLATLDYGEENNQPVKASAIQRRRISYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG20</accession>
    <name>Q2HG20_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220055.1">
        <property type="nucleotide sequence ID" value="XM_001220054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG20"/>
    <dbReference type="STRING" id="306901.Q2HG20"/>
    <dbReference type="GeneID" id="4387757"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00834"/>
    <dbReference type="eggNOG" id="ENOG502SIH3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036233_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HG20"/>
    <dbReference type="OMA" id="NMISPSY"/>
    <dbReference type="OrthoDB" id="5413188at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ92599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="485" mass="50102" checksum="9164E0564A90BD61" modified="2006-03-21" version="1">MAPSDTYRPRQAGLRNVSSAETTGRTDAPSAQRRNDGQLSAAASTFNQELMPVNSESWVEVTSQPSSSSSLSSIGDEIVTTGLRVGGISYPPRRRRTHQQHAMPASFIVGHPATQGGTTSSQEEYDETESEEDRVMTSSTEAVHPSASLPRHQTAMRASAVVDIDSESDDDENATALGRPSNSPVFRPQPNAFSHPPSHLAHRHSTGSAAYNHPSHSRPPMPNRPHARSHRGQSYMSPPNEADNDAALRASLTTLLSCAAAARGLPKNEERRTAPGAGAGVVPSSQPMELRLVPESELMATNSPPAPPTATPASGARAKTARTASNSSAPSAPSSSSGREHQQQQQQRDSKRGLPSTTQGRPARAAKKKRTSTTLLDGDSATDAAPFFSVSPTLLTWVVSAGVVVLVSVVGFGAGYVIGREVGRQEGGGSSVAAAASSSLVGSGGAAANASSAGAAGCGGELVRAGAGGTLRRFRWGGVGKSVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG62</accession>
    <name>Q2HG62_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyldiphosphate specific]</fullName>
            <ecNumber evidence="5">2.5.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_00792</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate</text>
            <dbReference type="Rhea" id="RHEA:53008"/>
            <dbReference type="Rhea" id="RHEA-COMP:19494"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:136960"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.87" evidence="5"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220013.1">
        <property type="nucleotide sequence ID" value="XM_001220012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG62"/>
    <dbReference type="FunCoup" id="Q2HG62">
        <property type="interactions" value="239"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HG62"/>
    <dbReference type="GeneID" id="4386843"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00792"/>
    <dbReference type="eggNOG" id="KOG2818">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051870_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HG62"/>
    <dbReference type="OMA" id="IYSHLPF"/>
    <dbReference type="OrthoDB" id="19639at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038887">
        <property type="entry name" value="Nus1/NgBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528:SF0">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ92557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="258" mass="29519" checksum="CD78A618D287B18F" modified="2006-03-21" version="1">MPFASELEAYRRDERLGHKLLTPEERLRLIRAYHAVANRIHLVYYHHHRTPELIRRDVKGLRRLPKHLSVILTLEDQRRSANQETGILKGYLKDTHQAISQEMHAYFGPNHPTVSLGAPHIPPLESDALPEGNDHHGSGSSDEDEEPRKHISIVLISAEDGRDSMVDLTKTLAEMSQRKKLNPADITPELVDAELTESVMSEPDLLILFSPHVELAGYPPWQIRLTEIFHVRDNQGVGYQVFYKGLRNFAEAQMRKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG87</accession>
    <name>Q2HG87_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_00767</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219988.1">
        <property type="nucleotide sequence ID" value="XM_001219987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG87"/>
    <dbReference type="STRING" id="306901.Q2HG87"/>
    <dbReference type="GeneID" id="4386872"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00767"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_33_1"/>
    <dbReference type="InParanoid" id="Q2HG87"/>
    <dbReference type="OMA" id="TKTGICE"/>
    <dbReference type="OrthoDB" id="4577091at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="74"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="116"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="156"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="197"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="242"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ92532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="302" mass="31677" checksum="F2706591BD92182D" modified="2006-03-21" version="1">MAQTTASAGEGTDNGNVQEPISHAVHESAGLPAPDEHSDDLHSADSDLGQLASASADGTVKIWDPATHQCSATLEGHGGSVFSVVWSPDGTQLASGSADRTIKIWNPATGQCTATLESHAGSVLSVAWSPDGTQLASASRDGPIEIWDLATAQMILEAFRELVLSVAWSPDGYKFASGPDDTIIKIWGWACTNSLTLEGHTRSVGSVAWSPDGARLASGSDDRTVKVWDLWDLDHGQCTATLSGHDKFVQSVTWSPNGARLASGSDDETVKIWDPITSECVATLGGHEDTVYSVAWSPGPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGR4</accession>
    <name>Q2HGR4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">INO80 complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219811.1">
        <property type="nucleotide sequence ID" value="XM_001219810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGR4"/>
    <dbReference type="STRING" id="306901.Q2HGR4"/>
    <dbReference type="GeneID" id="4387163"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00590"/>
    <dbReference type="eggNOG" id="ENOG502SECK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058488_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGR4"/>
    <dbReference type="OMA" id="KPCRRWA"/>
    <dbReference type="OrthoDB" id="4093188at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013175">
        <property type="entry name" value="INO80_su_Ies4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28061">
        <property type="entry name" value="INO EIGHTY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28061:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08193">
        <property type="entry name" value="INO80_Ies4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="27143" checksum="A1B69FDBB52BAA82" modified="2006-03-21" version="1">MAPSSKNAAVAKDRRKSANSTAPTVVSAGSPKPTQIVTLKVPAQKLRAILDPDFIKEDTPAKQSPAAAAASGTENASDSTPNSPPAGTPAAQSVTMGPPTEGLKKKGVKRSATAAANGNGEPKVRGKPGPKKKQRLEDGTIEGGRGSLAAHKLGPKANQGAINAGLRALDRSGKPCRKWSRGGFTLKTFTGVVWEIPRWTAPPKPRPEESADGSTAASESSNKENKEDNSQVKSEASNNGGDVEMQGTPSFAADNSPAPVPIAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHB9</accession>
    <name>Q2HHB9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219606.1">
        <property type="nucleotide sequence ID" value="XM_001219605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHB9"/>
    <dbReference type="GeneID" id="4387929"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00385"/>
    <dbReference type="HOGENOM" id="CLU_2014984_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHB9"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="123" mass="12822" checksum="7D881744805E817A" modified="2006-03-21" version="1">MPPLPIHIPQHVLQPVQREPERKDPRLGPVHDACQPARGGVDQEIHLAEVAVREGEGEGGEDGGEVVEEGGELGGESRGEGGGERGEGLGELGEERWGGRWGWGGWLLGAVPGLGEEPVGGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHF1</accession>
    <name>Q2HHF1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_00353</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219574.1">
        <property type="nucleotide sequence ID" value="XM_001219573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHF1"/>
    <dbReference type="STRING" id="306901.Q2HHF1"/>
    <dbReference type="GeneID" id="4387842"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00353"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="InParanoid" id="Q2HHF1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF168">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ92118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="491" mass="55126" checksum="4B0850228D96635B" modified="2006-03-21" version="1">MLHPTRIPPVLPSVGVQPNFNPTKLATPPPSSATVTTMIEKMSHLHELLGSLQAFVATPGTAIFAATAICSLIAAIHVFRAWWRLRHIPGPFLNSITPLVMTYHCFKEDVTTYTYNLTRKYGPLVRVQPNVVVYNDPETFRRICSVKADYTKGLWFEFSRWNLERYSCIAMRDNESRKERKTKLLPAASGPTPLSCGSPLLTMQQNQWAGQGLSVMEGRVDNQFYTLDVATSATFGKPFGFLKKDGDVEKYLEITESMTPMFGILGTLPWLVYVMHAWPLNRMMPGEGDKVGFGRMMNVAGSETTSVALRMALLSILTTPSAYRKLQAEIDNFHADKAAEADDKSVITYADARTLPYLQAVIREALRLWPPSAGLFTKEVPKAGDSIHGYYLPPGTEVGQCLSSVGKLPRIWGADADLFYPERWLEATPEKFEEMQAAVDLVFSSGKYVCLGKHIAWMELLKFFAEVIGSLAWDPITWLTTDFWIRFTRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHS2</accession>
    <name>Q2HHS2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7025 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_00232</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219453.1">
        <property type="nucleotide sequence ID" value="XM_001219452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHS2"/>
    <dbReference type="STRING" id="306901.Q2HHS2"/>
    <dbReference type="GeneID" id="4388260"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00232"/>
    <dbReference type="eggNOG" id="KOG0742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_445484_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHS2"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF2">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7025" evidence="3">
        <location>
            <begin position="322"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ91997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="613" mass="69510" checksum="6F54CB553058466A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHS5</accession>
    <name>Q2HHS5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219450.1">
        <property type="nucleotide sequence ID" value="XM_001219449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHS5"/>
    <dbReference type="GeneID" id="4388257"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00229"/>
    <dbReference type="eggNOG" id="ENOG502SIX4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072640_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHS5"/>
    <dbReference type="OMA" id="WEGGVYE"/>
    <dbReference type="OrthoDB" id="5175824at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="235" mass="27421" checksum="CF54E6C04ECCE1BE" modified="2006-03-21" version="1">MFSDHPDAYVEFLGSRYRGKEGIKRLYQGRFQNTFVKGRNGPVYGWLLDHIMMQDIVDVDESGTHAWCRMRALMQAGTHQSIEEYYPRGHRQWWEGGLYENEYIKENGAWKLFRYRYFPFWHAEFEKGWSHTKKNYIPWPTVTYPEDPLGPDEIFEQKMLWPDTRVVPFHYPHPVTGKPTAPDDLRAPVYGTDVDTSDPPLTLALPEGQSRPGATARESKPGEKVLPELVENKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHW1</accession>
    <name>Q2HHW1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219414.1">
        <property type="nucleotide sequence ID" value="XM_001219413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHW1"/>
    <dbReference type="STRING" id="306901.Q2HHW1"/>
    <dbReference type="GeneID" id="4387600"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00193"/>
    <dbReference type="HOGENOM" id="CLU_2222959_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHW1"/>
    <dbReference type="OrthoDB" id="2441380at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209272" description="Cyanovirin-N domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Cyanovirin-N" evidence="2">
        <location>
            <begin position="21"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="106" mass="11703" checksum="DCFB9593CBAD272D" modified="2006-03-21" version="1">MKISLLVVAVASLATQAAASYASSCRNCRLEKWNNDWLSGNEYGPILLCDCKQKDGKWHSSRLDLNHCIANNDGRMTSRKEGNLGRSCHGYGLSNSKIFGAHCKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI75</accession>
    <name>Q2HI75_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219300.1">
        <property type="nucleotide sequence ID" value="XM_001219299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HI75"/>
    <dbReference type="GeneID" id="4388285"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00079"/>
    <dbReference type="eggNOG" id="ENOG502T4YT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_767264_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HI75"/>
    <dbReference type="OrthoDB" id="5242458at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="361" mass="41276" checksum="21FAE903A0E3AB41" modified="2006-03-21" version="1">MSETIDSQTIEQIIPGTQPGVDDNTSNPVISLTDQNEHTILTVPVSQVQKQDALQRIAELSHKSATLATQGRSQEASASREGGADSTPSQDAANPRKRKYNKVLSKETHEAVWDRLKTVKFIFRISYLLELRPRNEEDLVEYYFGDVNGPSADFVKKYVHNRIVGISGTWQYRCLERLIHTQEMPIFATFKTGEQLHTYLKTLYTHDLFVELFDFCNGHIDIAGSERDVHKWCRALFVELLTCAKKHVDWLQLGPSRPMETLADGTPVCNRAWLINRWKSIAGAKSWQKIRFDPKNVKRVPKALAKRYQPKKKPEFQSVNDDPETYIPSDTEDKNDHCLLQHHSGGDYDLAFGEEDGIYQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HID0</accession>
    <name>Q2HID0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_00024</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219245.1">
        <property type="nucleotide sequence ID" value="XM_001219244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HID0"/>
    <dbReference type="ESTHER" id="chagb-q2hid0">
        <property type="family name" value="Acetylxylan_esterase"/>
    </dbReference>
    <dbReference type="GeneID" id="4387729"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00024"/>
    <dbReference type="eggNOG" id="ENOG502QUMZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040058_4_1_1"/>
    <dbReference type="InParanoid" id="Q2HID0"/>
    <dbReference type="OMA" id="CPNTREV"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF13">
        <property type="entry name" value="ACETYLXYLAN ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208996" description="CBM1 domain-containing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="8">
        <location>
            <begin position="262"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ91789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="298" mass="30222" checksum="EDA32AA0594D284C" modified="2006-03-21" version="1">MWPTPKVASLLLAAHALLVSGSPVDADAVDAAVLAKRQCPQIHVFGARETTVSPGYGTAGQVVNLILGAYPGATAEPISYPAYGDSARQGTSAVASAVNSFNQRCPNAQIVLVGYSQGGQIMDNAVCGGPDSGSGITSTAPPISAAALNQIKAVIMMGNPRYVAGLSYNVGTCSAQGFAPRPRGYVCGSNSADKMKSYCDSTDPYCCTGNDANSHQQYGTKYGQQALTFVKSKLSTSGGGGSQTTPSTPTPTGGNGGGNTGNCAAKWGQCGGSGWQGPTCCQSGSTCQASNQWYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMB4</accession>
    <name>Q2GMB4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226157.1">
        <property type="nucleotide sequence ID" value="XM_001226156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMB4"/>
    <dbReference type="GeneID" id="4397208"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10890"/>
    <dbReference type="HOGENOM" id="CLU_2922436_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GMB4"/>
    <dbReference type="OrthoDB" id="5598852at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ83072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="61" mass="6883" checksum="3D5EE5E966A2268C" modified="2006-03-21" version="1">MIGPLLTQIPRAMPGRFHRVFRDVLASPPDVLALPMVLLHKDLGDCNIMVRQEDRCLMAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMH5</accession>
    <name>Q2GMH5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226096.1">
        <property type="nucleotide sequence ID" value="XM_001226095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMH5"/>
    <dbReference type="GeneID" id="4397200"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10829"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_25_2_1"/>
    <dbReference type="InParanoid" id="Q2GMH5"/>
    <dbReference type="OrthoDB" id="3230070at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="505" mass="56768" checksum="24F6049154B7A384" modified="2006-03-21" version="1">MSVQTQEAGIILVVETGINILSKVDIPVIAGVPQSSPLSPILFILYIASLYQALKTAHPLVSIVGFADDTNLLAFGKNPETNTQQLEKAWKTCLQWAGRRQWENPVALAHPGASGYSTVKPVESARFLGVWLDWKLSWRAHQQAVERKLKTQDFALSRIAAKTWGPSLSRAREVYVKCIRSAIAYGASSFHQPTAPRATGPKGPAKVLSKAQNRSLRIVVGAYKSAPIRCLETEAWVPPLDLYLNKRLADFEGRLQKQALQSGAGPEAERITTGHLITEACNKVYRTFNKRRKTRGRRPRQGPQSPTPTELAASVVAQWVNYKWKIGGKDRGSNTKEVVELAWQARWEQQRASQQSATRQRVLNRRIADEDPPALLFTDKALMRHEGLTKAQSSLLSQARIGDIGLRDYLFRVKVPEVRTPYCECGRGRETVEHLVVWCPDPPLQRPWDGREIRSHRDLQTVLRGVGARSRRFVRKVLGWLMDSGRLLEYRLARRLELETVDGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN05</accession>
    <name>Q2GN05_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_10649</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228576.1">
        <property type="nucleotide sequence ID" value="XM_001228575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN05"/>
    <dbReference type="STRING" id="306901.Q2GN05"/>
    <dbReference type="GeneID" id="4397009"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10649"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025001_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GN05"/>
    <dbReference type="OMA" id="EFRVWCA"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ84245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="59867" checksum="4C562170E4D8BBA9" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN86</accession>
    <name>Q2GN86_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228495.1">
        <property type="nucleotide sequence ID" value="XM_001228494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN86"/>
    <dbReference type="STRING" id="306901.Q2GN86"/>
    <dbReference type="GeneID" id="4396447"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10568"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009958_6_1_1"/>
    <dbReference type="InParanoid" id="Q2GN86"/>
    <dbReference type="OMA" id="EWRTKYD"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF82">
        <property type="entry name" value="FAMILY CHAPERONE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G08575)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="594" mass="66200" checksum="474E2A293A0DE5A0" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN98</accession>
    <name>Q2GN98_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228483.1">
        <property type="nucleotide sequence ID" value="XM_001228482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN98"/>
    <dbReference type="GeneID" id="4396411"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10556"/>
    <dbReference type="eggNOG" id="ENOG502SCEJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076635_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GN98"/>
    <dbReference type="OMA" id="RDWKPNG"/>
    <dbReference type="OrthoDB" id="5408734at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14724">
        <property type="entry name" value="ZIP_Gal4-like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="217" mass="23151" checksum="DF76E1558126DD40" modified="2006-03-21" version="1">MSDQEMDREWQPNARRPQSTVAQMFSQELMDIFRIDNSVADLDEKVDKRKQQINSQASELEALEARIREMEARLKGQGSPIASSSSAKTGNAPPLPAKDYPVREQQKHAGSRPGTARQGQPAVRGALPPTPAGSEGEFAPSLLPPSRTAPRPPGPQAKTHLAASNVGTGARPASASRANEPSAPGGDADSIKSLSESASFADYVFVPEPDGDRERDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNH3</accession>
    <name>Q2GNH3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_10481</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228408.1">
        <property type="nucleotide sequence ID" value="XM_001228407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNH3"/>
    <dbReference type="STRING" id="306901.Q2GNH3"/>
    <dbReference type="GeneID" id="4396062"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10481"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_23_2_1"/>
    <dbReference type="InParanoid" id="Q2GNH3"/>
    <dbReference type="OMA" id="KWINAFC"/>
    <dbReference type="OrthoDB" id="5244787at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="4">
        <location>
            <begin position="309"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1074"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1080"/>
            <end position="1098"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ84077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1098" mass="122666" checksum="7689A0E7C43A19F7" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNJ5</accession>
    <name>Q2GNJ5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228386.1">
        <property type="nucleotide sequence ID" value="XM_001228385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNJ5"/>
    <dbReference type="GeneID" id="4396681"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10459"/>
    <dbReference type="HOGENOM" id="CLU_2015000_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNJ5"/>
    <dbReference type="OrthoDB" id="10463409at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="123" mass="13698" checksum="1339C4BF6EE2450C" modified="2006-03-21" version="1">MSDAAAHMGRLLVKTRRLASWQTARTLCCVRLFLRASSPADSPARLDLSGLNKKWANPQKAPCHVPCPCPCPWLVRRTPGPDQRRQAIQRTTTALALIVETASRALMHTSQPQRLSIEESNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPP3</accession>
    <name>Q2GPP3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pectate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_10061</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227988.1">
        <property type="nucleotide sequence ID" value="XM_001227987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPP3"/>
    <dbReference type="STRING" id="306901.Q2GPP3"/>
    <dbReference type="GeneID" id="4396581"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10061"/>
    <dbReference type="eggNOG" id="ENOG502QR5B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021894_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GPP3"/>
    <dbReference type="OMA" id="ATWGVEG"/>
    <dbReference type="OrthoDB" id="1637350at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF18">
        <property type="entry name" value="PECTATE LYASE 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="337"/>
        </location>
    </feature>
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        <location>
            <begin position="47"/>
            <end position="259"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ83657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="337" mass="36600" checksum="7B1C555078801215" modified="2006-03-21" version="1">MRLNFITVLSTLAPLAAASPLGSLGLASWGVEGFAKDNPIGTTTGGKGGATVVVDNAADLAAAVSGDKPKIVRVKGEIKLPARAKIGPNTSVIGVGGSAHITGSGLDVVDSTNVIIQNLKISFIEDNDCITIRNSTRVWVDHNEFKSDISKGPDFFDGQVDIIRASDWITVSWNYFHDHWKSSLVGNDDTFRDIDFGHLHVSYHHNYWRNMGTRGPAGRFGHQHIYNNLYVDFNYQAIHSRSDNQVLVEGNVFRGKTREALSTYGLVIPDDSPNTCTCGDEELDGYANLGAKNDWGKATVNITQVGDFKKAPYKFKLTPLPLVEPIVKLGAGVGRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPQ7</accession>
    <name>Q2GPQ7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227974.1">
        <property type="nucleotide sequence ID" value="XM_001227973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPQ7"/>
    <dbReference type="STRING" id="306901.Q2GPQ7"/>
    <dbReference type="GeneID" id="4396174"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10047"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006096_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPQ7"/>
    <dbReference type="OMA" id="WVEDAIA"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050829">
        <property type="entry name" value="CorA_MIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47685">
        <property type="entry name" value="MAGNESIUM TRANSPORT PROTEIN CORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47685:SF1">
        <property type="entry name" value="MAGNESIUM TRANSPORT PROTEIN CORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="669"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="883" mass="101568" checksum="EE8A2666D6E75DA7" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQ55</accession>
    <name>Q2GQ55_CHAGB</name>
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        <recommendedName>
            <fullName evidence="10">3'(2'),5'-bisphosphate nucleotidase</fullName>
        </recommendedName>
    </protein>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
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        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
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    </dbReference>
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    <dbReference type="GeneID" id="4396262"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="411145at2759"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF2">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="205"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="140"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="509"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ83495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="61726" checksum="3CD1F8F8E8425A6E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQR2</accession>
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        <recommendedName>
            <fullName evidence="4">cAMP-independent regulatory protein pac2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227619.1">
        <property type="nucleotide sequence ID" value="XM_001227618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQR2"/>
    <dbReference type="GeneID" id="4396432"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09692"/>
    <dbReference type="eggNOG" id="KOG4476">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027883_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GQR2"/>
    <dbReference type="OMA" id="RIMGKFL"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF1">
        <property type="entry name" value="CAMP INDEPENDENT REGULATORY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="56088" checksum="6F00DC8D3AAE52FF" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRD5</accession>
    <name>Q2GRD5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_09469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227396.1">
        <property type="nucleotide sequence ID" value="XM_001227395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRD5"/>
    <dbReference type="GeneID" id="4395688"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09469"/>
    <dbReference type="eggNOG" id="ENOG502RN5P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1224628_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRD5"/>
    <dbReference type="OMA" id="VTQHWEC"/>
    <dbReference type="OrthoDB" id="4729605at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208526" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ85455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="23958" checksum="110EAD42309F4C46" modified="2006-03-21" version="1">MRNHLVSFALATADAIYLPSGVNAARPCGGSNGGNFQYRLGDVRYDGPDPSKKNDLATIAASLQGSNGTPLYECVGQWPRRLGPGGTQGETDDSSHCVPKSTDSGTRPSLNIATALVPGSENASPTCVDTSKEYQSWRMENWQRSFKMEPGASPIDPKLSEDSGPSFTLKSSANGNTFNCSPSEGEDGAFAGSCTSSEGTSTTADFRFDPLLNMLEITEHWACEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRL4</accession>
    <name>Q2GRL4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227317.1">
        <property type="nucleotide sequence ID" value="XM_001227316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRL4"/>
    <dbReference type="GeneID" id="4395356"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09390"/>
    <dbReference type="HOGENOM" id="CLU_997491_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRL4"/>
    <dbReference type="OrthoDB" id="4589291at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="279" mass="31149" checksum="450FF7347E7CC813" modified="2006-03-21" version="1">MTSKSLPNFGPWGDNGNGSGSQTENASRNSDVLSPKESLANFSPPATPTPAISTPPSTTGSYDVKGDNRELVQPERSQIFRKYFSAESSEGQGWAVLCLRMTPDPGARCYKKAPWAALLEVRTADMPRLMRDGFFWSAENILPEEGHVSRETSPLWADFGFYHKRTWVLADRSNDEVPRWVGCLHILTPSFEILPSFQVQQLKPENAGGRGQEKKRWTVWVSDLRTSASVALSLARLRKPFPYPRNLNIFNILINGRRVVSFCNIGRPSYSQGPAAYNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRT0</accession>
    <name>Q2GRT0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227251.1">
        <property type="nucleotide sequence ID" value="XM_001227250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRT0"/>
    <dbReference type="GeneID" id="4395662"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09324"/>
    <dbReference type="HOGENOM" id="CLU_1069577_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRT0"/>
    <dbReference type="OrthoDB" id="440424at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="260" mass="24534" checksum="7769F286AE81BF93" modified="2006-03-21" version="1">MDAFRFIQDAVPFAQAALKTVEQAAAPALENLGASAAGLAQGAADAVAQAAPIAHAAIQSTGEAIAPALKVAAEQGVPFAHGVVQSAGEAIAPAFKIAAEQGVPFAHNAVQSVGEAIAPALQIAAEAGANGYTFAAANPAAVACGAVALGGLAIVAAPGILTGPALSAAGFTPLGPGAGRSFPLDRVKKGVTLTCLLLVVGTIAAMVQTPNVVAGGVFATLQSAGMGGYGAAVVAAAGQAVGGTVAAAGGAGVVLSNMAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-26" modified="2025-06-18" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GS33</accession>
    <name>VPS27_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Vacuolar protein sorting-associated protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">VPS27</name>
        <name type="ORF">CHGG_09221</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text>Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The FYVE domain is involved in the binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) which is required for the association to endosomal membranes.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Both IUM domains are necessary for efficient binding to ubiquitin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the VPS27 family.</text>
    </comment>
    <comment type="sequence caution" evidence="6">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAQ85207" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="6">
        <conflict type="frameshift">
            <sequence resource="EMBL-CDS" id="EAQ85207" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85207.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227148.1">
        <property type="nucleotide sequence ID" value="XM_001227147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GS33"/>
    <dbReference type="SMR" id="Q2GS33"/>
    <dbReference type="FunCoup" id="Q2GS33">
        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GS33"/>
    <dbReference type="GeneID" id="4394663"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09221"/>
    <dbReference type="HOGENOM" id="CLU_011862_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GS33"/>
    <dbReference type="OrthoDB" id="957735at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15735">
        <property type="entry name" value="FYVE_spVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21385">
        <property type="entry name" value="GAT_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16979">
        <property type="entry name" value="VHS_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1940:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000031">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000161">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017073">
        <property type="entry name" value="HGS/VPS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049425">
        <property type="entry name" value="Vps27_GAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
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        <property type="entry name" value="Vps27_GAT-like"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0967">Endosome</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000292513" description="Vacuolar protein sorting-associated protein 27">
        <location>
            <begin position="1"/>
            <end position="737"/>
        </location>
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        <location>
            <begin position="18"/>
            <end position="150"/>
        </location>
    </feature>
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        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
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        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="FYVE-type; degenerate" evidence="2">
        <location>
            <begin position="168"/>
            <end position="228"/>
        </location>
    </feature>
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        <location>
            <begin position="229"/>
            <end position="265"/>
        </location>
    </feature>
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        <location>
            <begin position="285"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="332"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="461"/>
            <end position="737"/>
        </location>
    </feature>
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        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
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        <location>
            <begin position="528"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="592"/>
            <end position="609"/>
        </location>
    </feature>
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        <location>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="686"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00218"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="737" mass="80463" checksum="A49F9DD9BEDE4624" modified="2007-06-26" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSD6</accession>
    <name>Q2GSD6_CHAGB</name>
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        <recommendedName>
            <fullName evidence="3">CST complex subunit STN1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Suppressor of cdc thirteen homolog</fullName>
        </alternativeName>
    </protein>
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        <name evidence="11" type="ORF">CHGG_09118</name>
    </gene>
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        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="77828at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:chromosome, telomeric region"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NA-bd_OB-fold"/>
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        <property type="entry name" value="RFA2-like"/>
    </dbReference>
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        <property type="entry name" value="Stn1_N"/>
    </dbReference>
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        <property type="entry name" value="CST COMPLEX SUBUNIT STN1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="CST complex subunit Stn1 N-terminal" evidence="10">
        <location>
            <begin position="44"/>
            <end position="90"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="189"/>
            <end position="271"/>
        </location>
    </feature>
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        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
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            <end position="263"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ85104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="284" mass="32764" checksum="72933B1ADE005FA6" modified="2006-03-21" version="1">MTDSTKPELYPQYCFHLSPTINRWCHFWITDIWALRSHPGFRGQDVYFHLNHPIKWVRISGVVVAVEEREKMHFYTIDDGSGETLECIVNVAPRARPGTATAATAAEPDSKSDKTSNSLPVVDAPIDVGHVLDIKGSVGTYRKNKQIRAEKVVHLRTTEQEVIFWEKVTQLKTDVLSKPWVLDRREVRKCRKEEEGRSSNSRQHRETRESHSRKRVIKTGLEKTETLRREKDRARTGERESKNRQESKPPVRLPKRETGLEKRRPAKPVTRLIPVTGNYDALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSF4</accession>
    <name>Q2GSF4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-keto-steroid reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_09100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227027.1">
        <property type="nucleotide sequence ID" value="XM_001227026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSF4"/>
    <dbReference type="FunCoup" id="Q2GSF4">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GSF4"/>
    <dbReference type="GeneID" id="4395235"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09100"/>
    <dbReference type="eggNOG" id="KOG1478">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029944_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSF4"/>
    <dbReference type="OMA" id="WTGINWP"/>
    <dbReference type="OrthoDB" id="9989144at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000253">
        <property type="term" value="F:3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051593">
        <property type="entry name" value="Ergosterol_Biosynth_ERG27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647:SF1">
        <property type="entry name" value="3-KETO-STEROID REDUCTASE ERG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647">
        <property type="entry name" value="DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0752">Steroid biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ85086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="51623" checksum="0AF0BA41CBF64F05" modified="2006-03-21" version="1">MAPAPWDAVPAENTLFVLVTGGNSGIGFGIGERLIDEYLTTRSLSSHLVVIPTTRSIKKSQETIDGLRKHAREFAETSTALRARAGPNYDPKQTTRRVHILSVQLDLCNLPSVRRCANQLVSGTVSSPSDDNDFVSISDAKIPRLDSIIFNAGMGGWYGLNWPKVFHNILTKGLVNATTWPTFKGGLSGHKIDPIKGTKGEKGTEQMGEVFCANVFGHYVFAQRLVPLLTRATDSTLPPGRIIWESSVEGDWESLSQDDFEAVKTEAAYESTKRLTDLMALTATLPTSQPSVAKYLNTTSTTPKTRPPKIYLVHPGVVQTTLFPLNAFMFFWYNIVLYVARWLGSPWHPITAYNGACAPVWVALQEQGWLDGARAERVKWGTSTDRAGECRVKKTEVDGWGWEGRVEEVRALKQEHKLTGRRPGAVDATAETLAGFEELGAECWRKMEELRERWEKRADAAEAGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSV0</accession>
    <name>Q2GSV0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_08954</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226881.1">
        <property type="nucleotide sequence ID" value="XM_001226880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSV0"/>
    <dbReference type="STRING" id="306901.Q2GSV0"/>
    <dbReference type="GeneID" id="4395016"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08954"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_12_1_1"/>
    <dbReference type="InParanoid" id="Q2GSV0"/>
    <dbReference type="OMA" id="PWKIRAN"/>
    <dbReference type="OrthoDB" id="2898618at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ84940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="351" mass="36644" checksum="02D39ECE5407E665" modified="2006-03-21" version="1">MEAPVPNPAPPKSVEDLFSVKGIVALITGGGTGIGLMMARALALAGAKRVYIVGRRVDVLQAAASSINRPSVVVPLYCDVTSRVSLESVVSVVETDVGHLHLLVCNAGVGGPQVRPPVPGLTALEEWRDEQMAVRCEDFNATFAVNSTSVWFTAMAFLKLLDEGNKREGWGGKGEGVSSQVVVTSSIAGFNKSAPGGWAYGPSKAAATHIAKSLSVVLPTWGIRANCICPGLFPSEMAAPIVQASGGSMTGENSTIRLDKSMVPLGRMGDETDMTGQILYLASRAGAYLNGNTIVVDGGRLGFGGSYFGSPSFTAMMRLLRLGSCPLLAPLRLGDVGQTGPHRRLSPCEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTB4</accession>
    <name>Q2GTB4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_08790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226717.1">
        <property type="nucleotide sequence ID" value="XM_001226716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTB4"/>
    <dbReference type="STRING" id="306901.Q2GTB4"/>
    <dbReference type="GeneID" id="4395427"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08790"/>
    <dbReference type="eggNOG" id="ENOG502S3II">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052684_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTB4"/>
    <dbReference type="OMA" id="VSVYSVW"/>
    <dbReference type="OrthoDB" id="4205486at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029208">
        <property type="entry name" value="COX14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14880">
        <property type="entry name" value="COX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="132"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ84776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="280" mass="30119" checksum="11F9A199DD51F5B2" modified="2006-03-21" version="1">MFETPEQKVARLRAAHERAKAAKVSKFDKVVDASRKVFDSAHKVTVAGLIGFTVLAGLVTAYTAVDMIMYNKKRSAEWAEAQMKLEADSLEAARIAYMTGKADEEQIALVEEQLERERVSGRKTSFFKDMSTNNHNNNNNNNKNKTHPSSPGSPPTSNAKKTPTPTPTPPPAPSAPMSPQSRLGYESLSDDDGAAGGAVRDSDLARAVERRQATLQAKAAAALERERENQRRGGLLDRVGVVEEEEGGKGKDGAGEGGDGKGIGGGAVGEGEKKKKGWWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTH9</accession>
    <name>Q2GTH9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226652.1">
        <property type="nucleotide sequence ID" value="XM_001226651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTH9"/>
    <dbReference type="STRING" id="306901.Q2GTH9"/>
    <dbReference type="GeneID" id="4394719"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08725"/>
    <dbReference type="eggNOG" id="ENOG502SKB6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024590_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTH9"/>
    <dbReference type="OMA" id="AKWFWEN"/>
    <dbReference type="OrthoDB" id="3595585at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="542" mass="59644" checksum="EDDB0180B5DC35F2" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTN6</accession>
    <name>Q2GTN6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA/RNA-binding protein Alba-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226595.1">
        <property type="nucleotide sequence ID" value="XM_001226594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTN6"/>
    <dbReference type="GeneID" id="4395459"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08668"/>
    <dbReference type="eggNOG" id="ENOG502SW4P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057902_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTN6"/>
    <dbReference type="OMA" id="CKMITVA"/>
    <dbReference type="OrthoDB" id="424402at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA-binding protein Alba-like" evidence="2">
        <location>
            <begin position="76"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="247" mass="27679" checksum="0797C62F819D590A" modified="2006-03-21" version="1">MAARDSTQSSFPNPHAAKRKFDNDSHDPSPKKRRAADAQLPNRTPNRTHNPAQTTSNYGQIHNPLLAKLSGKFEIKTMSVLPSTSIRKHVDRALGHLGRFSIWDKSVLPGVVLLCAKSSASTKLITIAEIIRRRIGESEQKWFQYNVPKETVIEEPPPSEDPSVVEDTYMDVDKEGGDDTDGEYFETRQPTIHEQAVQPAKVRYEAHVVILLSRLPLDELAAEPNVSSQTNERSIEHLRKKKMGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTT8</accession>
    <name>Q2GTT8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226543.1">
        <property type="nucleotide sequence ID" value="XM_001226542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTT8"/>
    <dbReference type="GeneID" id="4395848"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08616"/>
    <dbReference type="eggNOG" id="ENOG502RIVS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_520732_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTT8"/>
    <dbReference type="OMA" id="IRDCTMR"/>
    <dbReference type="OrthoDB" id="3561681at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="287"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="523" mass="59261" checksum="47AEC54FCE0111F8" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUQ8</accession>
    <name>Q2GUQ8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_08296</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ87043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225952.1">
        <property type="nucleotide sequence ID" value="XM_001225951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUQ8"/>
    <dbReference type="GeneID" id="4394476"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08296"/>
    <dbReference type="HOGENOM" id="CLU_013929_4_1_1"/>
    <dbReference type="InParanoid" id="Q2GUQ8"/>
    <dbReference type="OMA" id="YHLANCT"/>
    <dbReference type="OrthoDB" id="4589250at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="202"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ87043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="51004" checksum="D7C028B8127A4333" modified="2006-03-21" version="1">MAVEAIGKNKSLSIRAAARLYNVPEATIRHRRTGPSARRDLPANSHCVVLKIWPNHLLRERDAPPVGKLWAHNFVKRQPQLRTRRTRRYDYQRAKCKDPKVIGEWFTLVQNTRAKYGIVDDDVYNFDETGFMMGIIFAGMVVTTSDGRSKAKLAQPGNREWATVTQGVNALGWTIPPFIILAAQYHLANCTLTTIRRPGQRVYRLLILDGHESHHSTEFELYCRDNKIITLCIPPHSSHKCQPLDVGCFGPLKQAYGRLIEELMRAHINHITKFEFLGAFREAFFASMTEKNIQGTTAVMHQVALLQSEVSSLRKANEALSKQRRAKETRVQLGGSLTVQDAQDPLDQRAVGKGVVQETQPDGSGTGGGSFSPVCRCGMARKTFEHLVLECSGAADKSQPWPDDGAELLEWLDDVEKAAIVVRWVLGLGRLNEFRLAVELENEENNEEARGGAGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV53</accession>
    <name>Q2GV53_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CobW C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225807.1">
        <property type="nucleotide sequence ID" value="XM_001225806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV53"/>
    <dbReference type="STRING" id="306901.Q2GV53"/>
    <dbReference type="GeneID" id="4393770"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08151"/>
    <dbReference type="eggNOG" id="KOG2743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017452_2_1_1"/>
    <dbReference type="InParanoid" id="Q2GV53"/>
    <dbReference type="OMA" id="WSQAGPN"/>
    <dbReference type="OrthoDB" id="272672at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051927">
        <property type="entry name" value="Zn_Chap_cDPG_Synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43603">
        <property type="entry name" value="COBW DOMAIN-CONTAINING PROTEIN DDB_G0274527"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43603:SF1">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="2">
        <location>
            <begin position="283"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ86898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="536" mass="60236" checksum="A40D3F518715D885" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVE4</accession>
    <name>Q2GVE4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_08060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type 2 lipid phosphate phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225716.1">
        <property type="nucleotide sequence ID" value="XM_001225715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVE4"/>
    <dbReference type="FunCoup" id="Q2GVE4">
        <property type="interactions" value="324"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GVE4"/>
    <dbReference type="GeneID" id="4394618"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08060"/>
    <dbReference type="eggNOG" id="KOG2822">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019266_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GVE4"/>
    <dbReference type="OMA" id="ADDCPCY"/>
    <dbReference type="OrthoDB" id="301434at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF28">
        <property type="entry name" value="DIHYDROSPHINGOSINE 1-PHOSPHATE PHOSPHATASE LCB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="9">
        <location>
            <begin position="8"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ86807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="410" mass="44309" checksum="DE51B7AB0E7A4F61" modified="2006-03-21" version="1">MSGSAALEYGFPSTHSANAVSVAVYAVLMLHRETNPFSPSTTLALEGLAYFYALSIVIGRLYCGMHGFADVIIGSLMGAAISLVEFYYAPGLEAWLYNSEYLAPLIIALVIIVLVRVHPEPADDCPCFDDSVAFAGVMIGLELGMWRFARYSSIAPVYNGPDATFDLAALGWQRAVARLVFGVGMIFAWREVMKPALLRFLPHLYRVIETHGLSLPRRFFVPASEYKDVPLHVRDDNVLPNVSDLPKLVRSFRGPGRGRSVSIGPQSAADAYETLAYRERRRRESLGSDAGGGLKGRESVNGLREKAVVDGECSQASGVQSSSGGRLAEFEKMMGTGKVVTADPAAADGAPGTDLYLGQQDELGEKEVFSKLVKPRVRYDVEVVTKLVVYAGIAWLAVDGGLLAFEAVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVU9</accession>
    <name>Q2GVU9_CHAGB</name>
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        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_07905</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225561.1">
        <property type="nucleotide sequence ID" value="XM_001225560.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GVU9"/>
    <dbReference type="GeneID" id="4394367"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07905"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000263_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GVU9"/>
    <dbReference type="OMA" id="WGQKATF"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000050">
        <property type="entry name" value="Related to histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF74">
        <property type="entry name" value="HISTIDINE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAC" evidence="11">
        <location>
            <begin position="982"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="1041"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="1238"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1774"/>
            <end position="1901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="275"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="437"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="494"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="686"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="745"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="888"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1135"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1461"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1559"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="456"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
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            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="896"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1157"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1495"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1576"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ86652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1901" mass="207591" checksum="65629AEBB9856D7F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVX4</accession>
    <name>Q2GVX4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_07880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225536.1">
        <property type="nucleotide sequence ID" value="XM_001225535.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4394534"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07880"/>
    <dbReference type="eggNOG" id="KOG2029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_243369_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GVX4"/>
    <dbReference type="OrthoDB" id="5428055at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1454"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1485"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7025" evidence="5">
        <location>
            <begin position="106"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="569"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="966"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1143"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1398"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1524"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="966"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1004"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1039"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1078"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1161"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1187"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1406"/>
            <end position="1421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ86627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1625" mass="180431" checksum="329D3FDA39E9871A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWY4</accession>
    <name>Q2GWY4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_07520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225176.1">
        <property type="nucleotide sequence ID" value="XM_001225175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWY4"/>
    <dbReference type="FunCoup" id="Q2GWY4">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="GeneID" id="4394331"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07520"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_3_1"/>
    <dbReference type="InParanoid" id="Q2GWY4"/>
    <dbReference type="OMA" id="GPLECES"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000670">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF81">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="37"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ86267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="517" mass="55255" checksum="52AD5732FBCE654B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXP8</accession>
    <name>Q2GXP8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="14">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CHGG_07256</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="14"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224912.1">
        <property type="nucleotide sequence ID" value="XM_001224911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXP8"/>
    <dbReference type="FunCoup" id="Q2GXP8">
        <property type="interactions" value="455"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GXP8"/>
    <dbReference type="GeneID" id="4394633"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07256"/>
    <dbReference type="eggNOG" id="KOG0375">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_6_0_1"/>
    <dbReference type="InParanoid" id="Q2GXP8"/>
    <dbReference type="OMA" id="YPAACNF"/>
    <dbReference type="OrthoDB" id="5593063at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="16">
        <location>
            <begin position="145"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="375"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="476"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="485"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAQ86003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="520" mass="59755" checksum="916FF25C440424AA" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXX5</accession>
    <name>Q2GXX5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224835.1">
        <property type="nucleotide sequence ID" value="XM_001224834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXX5"/>
    <dbReference type="STRING" id="306901.Q2GXX5"/>
    <dbReference type="GeneID" id="4393407"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07179"/>
    <dbReference type="eggNOG" id="ENOG502SFQA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021365_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GXX5"/>
    <dbReference type="OMA" id="WFRTPPD"/>
    <dbReference type="OrthoDB" id="5379885at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="617" mass="67487" checksum="961F7CFE8D6704B4" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXY8</accession>
    <name>Q2GXY8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_07166</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224822.1">
        <property type="nucleotide sequence ID" value="XM_001224821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXY8"/>
    <dbReference type="FunCoup" id="Q2GXY8">
        <property type="interactions" value="855"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GXY8"/>
    <dbReference type="GeneID" id="4393566"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07166"/>
    <dbReference type="eggNOG" id="KOG0658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_20_1"/>
    <dbReference type="InParanoid" id="Q2GXY8"/>
    <dbReference type="OMA" id="MKTTMPM"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000055">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000009">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="35"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ85913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="394" mass="45166" checksum="6D0C376261C95D60" modified="2006-03-21" version="1">MASNRPAAFNNLRMGEVIREKVQDGITGETRDLQYTQCKIVGNGSFGVVFQTKLSPSNEDAAIKRVLQDKRFKNRELQIMRIVRHPNIVQLKAFYYSNGERKDEVYLNLVQEFVPETVYRASRFFNKMKTTMPTLEVKLYIYQLFRALAYIHSQGICHRDIKPQNLLLDPTTGVLKLCDFGSAKILVENEPNVSYICSRYYRAPELIFGATNYTTKIDVWSTGCVMAELMLGQPLFPGESGIDQLVEIIKVLGTPTREQIRTMNPNYMEHKFPQIKPHPFNKVFRKADANAIDLIGRLLEYTPTERLAAVNAMVHPFFDELRDPNTRLPDSRHGTGQVRDLPALFDFSRHELSIAPHLNDQLVPPHMIPVLMERGLDISNFTPMAKQEMMAKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GY67</accession>
    <name>Q2GY67_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homoserine kinase</fullName>
            <ecNumber evidence="3">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_07087</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Commits homoserine to the threonine biosynthesis pathway by catalyzing its O-phosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-homoserine + ATP = O-phospho-L-homoserine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:13986"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="3"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224743.1">
        <property type="nucleotide sequence ID" value="XM_001224742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GY67"/>
    <dbReference type="FunCoup" id="Q2GY67">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GY67"/>
    <dbReference type="GeneID" id="4393828"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07087"/>
    <dbReference type="eggNOG" id="KOG1537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041243_2_1_1"/>
    <dbReference type="InParanoid" id="Q2GY67"/>
    <dbReference type="OMA" id="CANRIPH"/>
    <dbReference type="OrthoDB" id="195231at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000068">
        <property type="entry name" value="Homoserine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF1">
        <property type="entry name" value="HOMOSERINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861">
        <property type="entry name" value="HOMOSERINE/4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00958">
        <property type="entry name" value="HOMSERKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="11" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="16">
        <location>
            <begin position="73"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="17">
        <location>
            <begin position="271"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00054121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ85834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="357" mass="38352" checksum="B3A70C0BF2A3DF88" modified="2006-03-21" version="1">MAQAESFVIKTPCSSANIGPGFDVIGLALSMYLELHVAIDRSKAQSEHPLNCRITYEGEGEGTDEISLDPQVNLITRVALYVLRCHGQRSFPAETHVHIKNPIPLGRGLGSSGAAVVAGVMLGKECGELHDLTPERLFDFCLMIERHPDNVGAALFGGFVGTYLKPLTPEDVARVEIPLSEVLPAPAGGVDTGAKPPSPPHGIGHHIKFPWAPEIKAVAIIPEFEVPTAKAREVLPSQYPRPDVTFNLQRIALLPVALGQSPPDPELIYLAMQDKLHQPYRQTLIPGLTEIVESMTPGTQPGLLGVCLSGAGPTILALATSNFAEIADRIIAKFKENKIVCNWKLLEPADGTTVTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GY90</accession>
    <name>Q2GY90_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_07064</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224720.1">
        <property type="nucleotide sequence ID" value="XM_001224719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GY90"/>
    <dbReference type="STRING" id="306901.Q2GY90"/>
    <dbReference type="GeneID" id="4394384"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07064"/>
    <dbReference type="eggNOG" id="KOG0975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031922_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GY90"/>
    <dbReference type="OMA" id="ICTDHMV"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000012">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF69">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ85811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="425" mass="46753" checksum="2E4117C0E02C9EAD" modified="2006-03-21" version="1">MGSRPPKSGNLRHSEPESRYCRYRISAFVYRGHVSTAPPGHINGNDTSTLPGLDASKLTITRADPTARAVPDEVAACSGNETICTDHMITVSWNAATGWAAPELKPYGPLSLMPTASVLHYATECFEGLKAYRGHDGGLRLFRPDLNAKRMLMSSLRISLPGFSPAELEKLILALMAVDGPKWLPRDRPGSYLYLRPAVIGTQPQLGVQASKEALLFITASFMPRMDAPAGGMRLHTNPEDMIRAWVGGFGYAKVGANYGPSLLATNEARSRGFGQILWLYGPEGYCTEAGASNFFVVWRTKEGGLEMVTAPLDDKLILDGVTRRSVVELARERLKGEVDVVERKYTIDEVIEADKEGRLVESFAAGTAFFICPVSQIRHREHDIHIPMAKGESGQYTAKIKGWMTDIMYGNEQHPWGVVVEEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYL5</accession>
    <name>Q2GYL5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ricin B lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224595.1">
        <property type="nucleotide sequence ID" value="XM_001224594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYL5"/>
    <dbReference type="STRING" id="306901.Q2GYL5"/>
    <dbReference type="GeneID" id="4394204"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06939"/>
    <dbReference type="eggNOG" id="ENOG502SH6C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103467_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYL5"/>
    <dbReference type="OMA" id="FDRKCAA"/>
    <dbReference type="OrthoDB" id="4426724at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208735" description="Ricin B lectin" evidence="1">
        <location>
            <begin position="18"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="19350" checksum="6AFBA57F81BA36FD" modified="2006-03-21" version="1">MRVLLTLLWAFAALTSATLTFTLQRAGNPTSDQNDAYQRIQSAMSAAVARYNRLAPRANKALTAQYVPSVATADGNFNGNIRFGSNRAYMNERTALHEISHTLGIGQTRAFDERCAANNWPGATRLLQSWDGQGAKINCGGGHIWPYGLNYDNEWSETNAERHCLLIDAMLADGLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZ20</accession>
    <name>Q2GZ20_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_05226</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224440.1">
        <property type="nucleotide sequence ID" value="XM_001224439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZ20"/>
    <dbReference type="GeneID" id="4391812"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05226"/>
    <dbReference type="eggNOG" id="ENOG502SMK9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_25_4_1"/>
    <dbReference type="InParanoid" id="Q2GZ20"/>
    <dbReference type="OMA" id="HIWDFKF"/>
    <dbReference type="OrthoDB" id="3934549at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="44"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="235"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ88607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="407" mass="45009" checksum="F5B3923BB6BC541F" modified="2006-03-21" version="1">MRLPPPEVVASWPVPNYINPEKQGPTLLIVELTTLSIALICLGLRLYARKQRLGVLAADDWLMIAAAPFGIGVTTCVVLAFVRYGWDVHVWDLTFEKILSGRKVSFAAQALFVPATALAKLSILYSYLRLAQTKPRFRRAIYGAMVFVVALNVCFIFVLFFQCRPSRLCVGSGDAAEPSQHNSRRRLCRVGVADTGILLHADGTAETARRHRPLQLRHVRRHRGLYPCYWIHYVVQETYDVTWYGFHLWLWTALEVHLGIICGCVPWMRSLSTLRRDKRNARAQKGTIGNVSSVAELINMDSSRRRSLGQAAKVTEGGPVVRVGSIASTSTRRGGGSQRLGGVVRGYLEDIERGSIYSIPPPPVPVEPATAVPVNKSVRPAHAELRTDRPVGLAVDHVPPNTPGLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZF1</accession>
    <name>Q2GZF1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_05095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05095"/>
    <dbReference type="eggNOG" id="KOG1075">
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    <dbReference type="HOGENOM" id="CLU_000680_23_2_1"/>
    <dbReference type="InParanoid" id="Q2GZF1"/>
    <dbReference type="OrthoDB" id="4368687at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="1240"/>
        </location>
    </feature>
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        <location>
            <begin position="143"/>
            <end position="188"/>
        </location>
    </feature>
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            <begin position="283"/>
            <end position="321"/>
        </location>
    </feature>
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        <location>
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            <end position="282"/>
        </location>
    </feature>
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        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
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        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ88476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1740" mass="193645" checksum="90A19C02C45BAA76" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZI3</accession>
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    </protein>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001224276.1"/>
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    <dbReference type="AlphaFoldDB" id="Q2GZI3"/>
    <dbReference type="GeneID" id="4392644"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05063"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_298592_0_0_1"/>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
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    </dbReference>
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        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF10551">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="233"/>
            <end position="328"/>
        </location>
    </feature>
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        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1006" mass="114416" checksum="220219A4407A2570" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H046</accession>
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        <recommendedName>
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    </protein>
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    <organism evidence="17 18">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
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            <location evidence="2">Microtubule organizing center</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SPC24 family.</text>
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    </dbReference>
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    <dbReference type="STRING" id="306901.Q2H046"/>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013252">
        <property type="entry name" value="Ndc80_Spc24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038066">
        <property type="entry name" value="Spc24_Fungi_globular_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08286">
        <property type="entry name" value="Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143026">
        <property type="entry name" value="Kinetochore globular domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-0132">Cell division</keyword>
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    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="305"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="410"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="367"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAQ88231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="453" mass="50497" checksum="E212B865001883DB" modified="2006-03-21" version="1">MLLEEDPSTLIRHTISNFNIAPDKTAVSRVSESLSTLQQARELRVRDAEESLRQLGRTLGKLSSQHAELTASHSSTQHASEIARLDTQKFRVAKAASDLEMETERLQAQLADLNARLQELELQGVDGGGVGIGEGSGGAGAGSGGALEDELLLRLKVYRSLGIEIERDSKDGEFNRVVVRNDRKGDVHVVNIDRKFSRFFYANYFWQTMANHIENTIMGRIVLAAIKFSVWTFIIVGIFPVVLVTAAISGTSVFLFLPLTLLYIYCKGMCSYIYDNTIGGPNPNSPNCPEFQQAMARYSRFWQDNAPPITPPNTPPPITPPPTPQETDDESDSDHYLSVHHPYTLLSRRLHFLNLYPANQRRGTLAGREHHAQTFQDEHASDDSPGAIGRRFDDEAVARWLDDYEDDGYFEDDGYFEDDGGYEDDGDYEDDGGDERSGLVTRAVVGLMPCRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H051</accession>
    <name>Q2H051_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_04845</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224059.1">
        <property type="nucleotide sequence ID" value="XM_001224058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H051"/>
    <dbReference type="FunCoup" id="Q2H051">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H051"/>
    <dbReference type="GeneID" id="4391876"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04845"/>
    <dbReference type="eggNOG" id="KOG4150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000809_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H051"/>
    <dbReference type="OMA" id="GAVHLHQ"/>
    <dbReference type="OrthoDB" id="18781at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17923">
        <property type="entry name" value="DEXHc_Hrq1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18797">
        <property type="entry name" value="SF2_C_Hrq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055227">
        <property type="entry name" value="HRQ1_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957:SF3">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="MZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22982">
        <property type="entry name" value="WHD_HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="411"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="588"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="992"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1100"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="992"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1002"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1117"/>
            <end position="1137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ88226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1137" mass="124332" checksum="C4CF6E14C4454A59" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0A0</accession>
    <name>Q2H0A0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">AIM41</name>
        <name evidence="2" type="ORF">CHGG_04796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM41 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224010.1">
        <property type="nucleotide sequence ID" value="XM_001224009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0A0"/>
    <dbReference type="GeneID" id="4392436"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04796"/>
    <dbReference type="eggNOG" id="ENOG502SDB7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079430_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H0A0"/>
    <dbReference type="OMA" id="RWNSTGP"/>
    <dbReference type="OrthoDB" id="538640at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="entry name" value="Uncharacterised protein YqeY/AIM41 PF09424, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="198" mass="21132" checksum="8D15E6E3766A97A0" modified="2006-03-21" version="1">MASKLPMLLRSFGRPTLPRTAALRVSRAAYSTEPPAPPPPLLAKLKDDLKAAMRAKDANRLAVLRAVLAETLNASKTDKPIKTDVQLVGLLQKSARKSQEAAAEARQAGREDLAEKEEAQQRILEEYAAGSGVKEMGEAELRQVIESAKAALVAQGVKGAALHGEIIKNIFKPGGLLDGASFDKKRAVTLIKEACQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0Q8</accession>
    <name>Q2H0Q8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_04638</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223852.1">
        <property type="nucleotide sequence ID" value="XM_001223851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0Q8"/>
    <dbReference type="GeneID" id="4392281"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04638"/>
    <dbReference type="eggNOG" id="ENOG502S23D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120561_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H0Q8"/>
    <dbReference type="OMA" id="ESPRSYC"/>
    <dbReference type="OrthoDB" id="5525680at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF3">
        <property type="entry name" value="DUF DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11150)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="66"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ88019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="142" mass="15852" checksum="6B535F7886DC8F3A" modified="2006-03-21" version="1">MPASTMPPLDEEESPRSYCDCCGPLTSLARPVDVSELDDHGIVQNAFCFPPIFGPLLFDNEQSDCRDHCANERTFLSYLRLSMYMSIVAVAIVLSFHLRKTASDVELRMAKPLGAIFWVLSKRSISTVGGRLLCRVGGRRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0X0</accession>
    <name>Q2H0X0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Poly A polymerase head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_04576</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223790.1">
        <property type="nucleotide sequence ID" value="XM_001223789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0X0"/>
    <dbReference type="FunCoup" id="Q2H0X0">
        <property type="interactions" value="111"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H0X0"/>
    <dbReference type="GeneID" id="4391775"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04576"/>
    <dbReference type="eggNOG" id="KOG2159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019592_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H0X0"/>
    <dbReference type="OMA" id="WQKFLDH"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CC tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:CCA tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734:SF5">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734">
        <property type="entry name" value="TRNA-NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="6">
        <location>
            <begin position="48"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="7">
        <location>
            <begin position="220"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ87957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="59139" checksum="008DD6446F799970" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0Y7</accession>
    <name>Q2H0Y7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_04559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223773.1">
        <property type="nucleotide sequence ID" value="XM_001223772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0Y7"/>
    <dbReference type="GeneID" id="4391642"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04559"/>
    <dbReference type="HOGENOM" id="CLU_2867480_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H0Y7"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ87940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="64" mass="7196" checksum="14DCF54EB4EC1204" modified="2006-03-21" version="1">MAVKEPACFPQQHKARSAGLGVLHATPPDAAQAQQHHARRAAMQRIFSPVEQALLWRWHIYSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H167</accession>
    <name>Q2H167_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_04479</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="domain">
        <text evidence="6">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223693.1">
        <property type="nucleotide sequence ID" value="XM_001223692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H167"/>
    <dbReference type="STRING" id="306901.Q2H167"/>
    <dbReference type="GeneID" id="4392411"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04479"/>
    <dbReference type="eggNOG" id="KOG0819">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025300_4_1_1"/>
    <dbReference type="InParanoid" id="Q2H167"/>
    <dbReference type="OMA" id="VRGPLMQ"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000002">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000005">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009117">
        <property type="entry name" value="ANX14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01813">
        <property type="entry name" value="ANNEXINFUNGI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0041">Annexin</keyword>
    <keyword evidence="3 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 6" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ87860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="483" mass="53663" checksum="B606C7C079671837" modified="2006-03-21" version="1">MSYSGYPPYGQPPPQQQGGYYQQPPPHQPYGAPPPPAQGQYYQQSPQPPQGYGQPPPSQPYGAPSPQPYGAPPPPQPYGAAPPPGQYYPPPQQGGYGAPPPPPQQPYGAPPPPPQQPYGAPQGHGQPPPQQPYGQPPYGQPPYGQPPPQQYQPYGQQYPPTPPSAGYGPPQIIAWNGDEDARGLRSAMKGFGTDEKALIRILATKDPLQANTMRDAYARLHRRDLIADIKSETSSWFEAGLVALARGPLLNDVHLLREAMSGPGTKEKALNDVLLSRSNADINAIKGEYHRVFHRRLEDDVRGDLSMKTERHFMIVLQAQRAEDSAPIVKAEIDRDVNDLYNATEAKMGTDEMKVCSILTTRNDNQIRAIAYEYQQKFARNLEDVIRKEFSGHMEDALLFQLRSGADKYMHQATLLEDAMAGAGTKDYLLVSRIVRFHWDRNHMANVRGAYEKRYHRNLASRIKGETSGDYERLMLACIGERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H183</accession>
    <name>Q2H183_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_04463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223677.1">
        <property type="nucleotide sequence ID" value="XM_001223676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H183"/>
    <dbReference type="STRING" id="306901.Q2H183"/>
    <dbReference type="GeneID" id="4393079"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04463"/>
    <dbReference type="eggNOG" id="ENOG502S4BQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048755_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H183"/>
    <dbReference type="OMA" id="DVDPYLC"/>
    <dbReference type="OrthoDB" id="63112at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030681">
        <property type="term" value="C:multimeric ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013893">
        <property type="entry name" value="RNase_P_Rpp40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15396">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15396:SF1">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08584">
        <property type="entry name" value="Ribonuc_P_40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ87844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="234" mass="26216" checksum="4A8700466D3E8694" modified="2006-03-21" version="1">MYLEREAYERAGLMGKPHGVKGKRGAKPRWIVEFDLTAPSMVPGKKGFDRLVYASKNALAQPITWLFCNSSTTPDPDPMSQHALTDCTSKPEISESINAVIPELTPDVGFLSSTSREDFEDFATSLYEWLSLVRLQSPRIQAGDQIDPYLSRYQVLDGGSEGRLCKISWQGFLAPSWTRQALIDIVTTLPHKAWFSFSTTTFSKGLAGDNAECIILRPPNSSGEYLMWEVKYHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1U2</accession>
    <name>Q2H1U2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_04254</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223468.1">
        <property type="nucleotide sequence ID" value="XM_001223467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1U2"/>
    <dbReference type="FunCoup" id="Q2H1U2">
        <property type="interactions" value="1181"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H1U2"/>
    <dbReference type="GeneID" id="4391782"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04254"/>
    <dbReference type="eggNOG" id="KOG0360">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_5_1_1"/>
    <dbReference type="InParanoid" id="Q2H1U2"/>
    <dbReference type="OMA" id="RGPNDYQ"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03335">
        <property type="entry name" value="TCP1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000009">
        <property type="entry name" value="T-complex protein 1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02340">
        <property type="entry name" value="chap_CCT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ87635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="566" mass="61711" checksum="0EF27BC764C0DC43" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1W9</accession>
    <name>Q2H1W9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223441.1">
        <property type="nucleotide sequence ID" value="XM_001223440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1W9"/>
    <dbReference type="GeneID" id="4392032"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04227"/>
    <dbReference type="eggNOG" id="ENOG502TFFI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_654136_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H1W9"/>
    <dbReference type="OrthoDB" id="3863715at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="431" mass="47220" checksum="FC9B77C73BC3AAC9" modified="2006-03-21" version="1">MRIDLASGNCTAVYDEPQTSKKDPTAPSKVPVTKNENPVDLDKPLEMPAKHKTVKTTRADETVASATNNKAGNPGGDREVAKTTTAGNTSEKNNEKPVREGDVFFRRLTRALPRSSRKTRPGLTHSTRRSQMRALLENDATNHPLFREMLARSCCPQHTVSSANAGPFGPICGNPVCGAFGHTLAVCPIPTTLDGDMSGCFFCNVVDHDADDCAMMEWVSPATLVTHLITNRAGMPPWNTRIDWVTLAIGEWDIGVSPITDPLFERADLKSLKALAKPELGGLHSRPPLMEASRSLCYCRHGCLDGLEHVIFKNKAIRKYIAEVKVTYKVKGPLLSDRERVLAVCQAQMAKKTPKQVTKERKGRRAMKKEAMAATASEKHPTSPNEPKDQAVKEHSAPSEAENPVPLSQRLMELADTVGDVLENIQKTMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H245</accession>
    <name>Q2H245_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223365.1">
        <property type="nucleotide sequence ID" value="XM_001223364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H245"/>
    <dbReference type="GeneID" id="4393100"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04151"/>
    <dbReference type="HOGENOM" id="CLU_2483158_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H245"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="87" mass="10016" checksum="DF5AF4814068C15D" modified="2006-03-21" version="1">MKLRGPQPKPGDCRRRLGMGMNRESGRDRLSRNYIDFTPFPPATTPSPLFLLPQPLRNLHMTPKTGNLPWSPPLISRRLEHIRTTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2K7</accession>
    <name>Q2H2K7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223203.1">
        <property type="nucleotide sequence ID" value="XM_001223202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2K7"/>
    <dbReference type="STRING" id="306901.Q2H2K7"/>
    <dbReference type="GeneID" id="4392092"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03989"/>
    <dbReference type="eggNOG" id="ENOG502QUFM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020613_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2K7"/>
    <dbReference type="OMA" id="EWKINRT"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.10">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32303:SF10">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN ASSEMBLY FACTOR BAMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32303">
        <property type="entry name" value="QUINOPROTEIN ALCOHOL DEHYDROGENASE (CYTOCHROME C)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208718" evidence="2">
        <location>
            <begin position="20"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="483" mass="51571" checksum="62C08F77FD0BE5E7" modified="2006-03-21" version="1">MKAFPKLSLVLSLSSLVAASGGINSWAGWGGSHLNNHWAEGNRDLSSRSIASLSLHCKIPDPVGQSAPPAIRGSYAYYPTYNGSFIALNYKTCEIKWNLNVTQVIADYAPITPLQLLVSVAVSRTSPQIDAANKILFFGTQIHALVVAADLDTGTVLGVQQVNPHELATITSSPTLYDNTLFVGVSSAEENAAYFTNGTYPCCSFIGNAAAFHFTRTHTSGTTTTMGTTPHRLQFTTLWNITTIPTNLPPPPLTPGEAGPPLRWSGAGIWGSQPPIDVARHQIIFATGNTYTVPQAFFHCAEAGADEHCFPSYVWQESVFALDLRSGRANWVRRLDALDAWTLVCGTGDLPRNETLCPFTPGPDADFGMAPAIVRGGARGYGEGGGRRDLLTVGQKSGVLYGLAADTGAVLWVGADEPGGYARGFVVGGWRRMMSGCIIPGVNSGQQEWVLQPQNKTAVNNSVIGAASGERDRSDTFRRARAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2P5</accession>
    <name>Q2H2P5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fatty acid synthase subunit alpha</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
            <ecNumber evidence="3">2.3.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_03951</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EC" id="2.3.1.41" evidence="3"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223165.1">
        <property type="nucleotide sequence ID" value="XM_001223164.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2H2P5">
        <property type="interactions" value="297"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H2P5"/>
    <dbReference type="GeneID" id="4392810"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03951"/>
    <dbReference type="eggNOG" id="ENOG502QQJX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000114_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2P5"/>
    <dbReference type="OMA" id="FPTLPDW"/>
    <dbReference type="OrthoDB" id="4251012at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101026">
        <property type="term" value="P:mitotic nuclear membrane biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900535">
        <property type="term" value="P:palmitic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00828">
        <property type="entry name" value="elong_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08950">
        <property type="entry name" value="KR_fFAS_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2490:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.25.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040899">
        <property type="entry name" value="Fas_alpha_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047224">
        <property type="entry name" value="FAS_alpha_su_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026025">
        <property type="entry name" value="FAS_alpha_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041550">
        <property type="entry name" value="FASI_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18325">
        <property type="entry name" value="Fas_alpha_ACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18314">
        <property type="entry name" value="FAS_I_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000454">
        <property type="entry name" value="FAS_yeast_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 13 14" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="16">
        <location>
            <begin position="138"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="17">
        <location>
            <begin position="1088"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="14">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ87332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1513" mass="166530" checksum="30A50A393380AA25" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-05-29" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H332</accession>
    <name>HOG1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Mitogen-activated protein kinase HOG1</fullName>
            <shortName>MAP kinase HOG1</shortName>
            <ecNumber evidence="2">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">HOG1</name>
        <name type="ORF">CHGG_03814</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Proline-directed serine/threonine-protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Activated by tyrosine and threonine phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Dually phosphorylated on Thr-171 and Tyr-173, which activates the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223028.1">
        <property type="nucleotide sequence ID" value="XM_001223027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H332"/>
    <dbReference type="SMR" id="Q2H332"/>
    <dbReference type="FunCoup" id="Q2H332">
        <property type="interactions" value="508"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H332"/>
    <dbReference type="GeneID" id="4392981"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03814"/>
    <dbReference type="eggNOG" id="KOG0660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="Q2H332"/>
    <dbReference type="OMA" id="NRYTDLN"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07856">
        <property type="entry name" value="STKc_Sty1_Hog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000049">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000050">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038783">
        <property type="entry name" value="MAPK_Sty1/HOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000289680" description="Mitogen-activated protein kinase HOG1">
        <location>
            <begin position="1"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="TXY">
        <location>
            <begin position="171"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4 5">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="26"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphothreonine" evidence="1">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine" evidence="1">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P32485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q16539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <sequence length="360" mass="41388" checksum="DBE6851C8C428791" modified="2006-03-21" version="1">MAEFVRAQIFGTTFEITSRYSDLQPVGMGAFGLVCSAKDQLTSQNVAIKKIMKPFSTPVLAKRTYRELKLLKHLKHENVISLSDIFISPLEDIYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQIMRGLKYVHSAGVVHRDLKPSNILVNENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMLEGKPLFPGKDHVNQFSIITELLGTPPDDVINTIASENTLRFVKSLPMRERQPLKNKFKNADPTAIDLLERMLVFDPKKRITATEALAHEYLAPYHDPTDEPTAELKFDWSFNDADLPVDTWKIMMYSEILDYHNVEAASVGEMENQQQYLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H351</accession>
    <name>Q2H351_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223009.1">
        <property type="nucleotide sequence ID" value="XM_001223008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H351"/>
    <dbReference type="STRING" id="306901.Q2H351"/>
    <dbReference type="GeneID" id="4393043"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03795"/>
    <dbReference type="eggNOG" id="ENOG502QSMW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026434_0_2_1"/>
    <dbReference type="InParanoid" id="Q2H351"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050723">
        <property type="entry name" value="CFA/CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667">
        <property type="entry name" value="CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667:SF2">
        <property type="entry name" value="FATTY ACID C-METHYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="348" mass="38173" checksum="78BFA14867C2102F" modified="2006-03-21" version="1">MAPLFSPIGLVGFFLRHLYSCTAYSLNNLRCLIFGKAITIARSSILCLLSSIEIGTLILVDEPFGECHVFGQLRDSDDDLDVDGDGELDLDAKVNTHGPASLTNSIVTLAVSPPLFYTRLLPHADMGFAESYLLEEVTCDDLTAFFRLFIINRARLNNGSTWWSAFLGTVVSRLTRLITCLGTTPNTAEAALRNAAAHYDLGNDLFAAFFSPRHDLLVPDLAYQRQFHVWAGERVRREGLVGYREVPGPFGEFWVGEDAGRGGEGGEGGEGGEGEDRGEDVGGGQGEDDAGRYDRIVSVEMIEAVGKDFLATYLRTVDRLLKKNGGIAVFQCITMPEGRQAAYEWREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H489</accession>
    <name>Q2H489_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_06526</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222621.1">
        <property type="nucleotide sequence ID" value="XM_001222620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H489"/>
    <dbReference type="GeneID" id="4390163"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06526"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_25_3_1"/>
    <dbReference type="InParanoid" id="Q2H489"/>
    <dbReference type="OMA" id="GHDPVQV"/>
    <dbReference type="OrthoDB" id="4161376at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ89907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="525" mass="55342" checksum="3E2A68B9AA75EE5D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H511</accession>
    <name>Q2H511_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_06254</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DIF1/spd1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222349.1">
        <property type="nucleotide sequence ID" value="XM_001222348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H511"/>
    <dbReference type="GeneID" id="4390303"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06254"/>
    <dbReference type="eggNOG" id="ENOG502S8VH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050885_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H511"/>
    <dbReference type="OMA" id="PFCGINR"/>
    <dbReference type="OrthoDB" id="4072855at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990846">
        <property type="term" value="F:ribonucleoside-diphosphate reductase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013900">
        <property type="entry name" value="RNR_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28081:SF1">
        <property type="entry name" value="DAMAGE-REGULATED IMPORT FACILITATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28081">
        <property type="entry name" value="DAMAGE-REGULATED IMPORT FACILITATOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08591">
        <property type="entry name" value="RNR_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="141"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="162"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ89635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="330" mass="34920" checksum="43CAB380755D8D5A" modified="2006-03-21" version="1">MAGPRTKRQFAGAASDPAQRSITSFFNKTTNTTTSANAASKTTSEPPLNGPHIPGQVQTDLLNVGMRVRKAIPEGYKTGSAYSGFTLWAEDNAVRKPTPTEDTYAIKTTTNPTTAPTSYLRELEPFCGINRVGGLAFQPSHNNGSSAMNDMDDMDAMPGLASSQDTISSTPSSFPSSFPTTTTTTIITTPTPTRKRIFTSDEDDAATTTTPNNSSTTTLPYRGPVRLSSDSPEAWLLELEEEISPRSAAPPPGLWESARVLAVPRSRARAQQVGLGLGSGGGGKGSSVGGVGGQEENVMVVVRREDGNDFEEASFLDYGLTAADGRMDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5F7</accession>
    <name>Q2H5F7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_06108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222203.1">
        <property type="nucleotide sequence ID" value="XM_001222202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5F7"/>
    <dbReference type="STRING" id="306901.Q2H5F7"/>
    <dbReference type="GeneID" id="4390703"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06108"/>
    <dbReference type="eggNOG" id="ENOG502T6VZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_7_5_1"/>
    <dbReference type="InParanoid" id="Q2H5F7"/>
    <dbReference type="OMA" id="LAPWNAQ"/>
    <dbReference type="OrthoDB" id="4589375at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="46"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="572" mass="63222" checksum="730F58C15874819B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5H1</accession>
    <name>Q2H5H1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_06094</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222189.1">
        <property type="nucleotide sequence ID" value="XM_001222188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5H1"/>
    <dbReference type="STRING" id="306901.Q2H5H1"/>
    <dbReference type="GeneID" id="4391005"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06094"/>
    <dbReference type="eggNOG" id="ENOG502QRET">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035914_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H5H1"/>
    <dbReference type="OMA" id="IYWIWQA"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF125">
        <property type="entry name" value="N-ACETYL-6-HYDROXYTRYPTOPHAN OXIDASE IVOB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ89475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="404" mass="44121" checksum="9A36274994E9617C" modified="2006-03-21" version="1">MRFSLLVPAIGTFVFGATFIVAARPNDAAAILQDLQRKVEAKLHETNKTAPGSLPGHGGQTCTLANAAVRKDWYLYPLFFSSNILRRLGTKALVGAVPLFAARLPTSVLPSVDPDFSAAQNHFDDFVAVHMNQTNFIHGTANFLTWHRYLIWLWEQKLRNDCGYTGYLPYWNWFKYQDDLSKSPVFDGSDTSLGGDGEYFAHNGSVVGAGRVWLPSGEGGGCVKSGPFVGYTINIGPVQPAMQGYTPVFTDVKHLNPRCQRRDLTTAASTSTFTAANLLNLTTGPASATVGHFQDELQGPYGTLRIHGAGHYAMGGDGSDVFTSLNDPAFYLHHAMVDRLYWIWQVLHPAEAHKVNGTVTFRNNPPSREGTVDDLLDVGKLGPAVPIRDVLDTLGGSPLCYIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5L9</accession>
    <name>Q2H5L9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_06046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222141.1">
        <property type="nucleotide sequence ID" value="XM_001222140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5L9"/>
    <dbReference type="STRING" id="306901.Q2H5L9"/>
    <dbReference type="GeneID" id="4389949"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06046"/>
    <dbReference type="eggNOG" id="ENOG502T3TZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029366_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5L9"/>
    <dbReference type="OrthoDB" id="2564527at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="527"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="632" mass="69472" checksum="4D8E2B8E9C4D5FFB" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5M4</accession>
    <name>Q2H5M4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_06041</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222136.1">
        <property type="nucleotide sequence ID" value="XM_001222135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5M4"/>
    <dbReference type="GeneID" id="4389955"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06041"/>
    <dbReference type="eggNOG" id="ENOG502SD7F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_818898_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5M4"/>
    <dbReference type="OMA" id="RWRWWCE"/>
    <dbReference type="OrthoDB" id="4581967at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ89422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="38149" checksum="66956556EA6F6749" modified="2006-03-21" version="1">MPPPMFQVAGRLLRFSARTFLSSLPFVRLGNTNACRLLSITNGPRARNCMVHPMERRGISHSAPYGHACMSCFKAKCRCVPRQNGDGCERLGLRCLRLKKPCTPSNSTRRRVHPDQKPNSDGRLTPFEDLVSLFHSRHNYKANAAAQQQQWAQSGFPSVEGICRLEALLDPFLEIPSNTTSANTPEPLDASTAACLETFRFHMLPNFPFIHFPAETTIQQLQYQRPFLFRAITCVASSTACEKRVRVAELKHLLSETVFGEKAENISQRNAMGHTMDLLLGLLVYVAWGWDHQFSGRLMTVAMSLVDEDHRHESWFQEWDVMAESAQIEAADEEAGASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5N5</accession>
    <name>Q2H5N5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_06030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222125.1">
        <property type="nucleotide sequence ID" value="XM_001222124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5N5"/>
    <dbReference type="STRING" id="306901.Q2H5N5"/>
    <dbReference type="GeneID" id="4390430"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06030"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_3_0_1"/>
    <dbReference type="InParanoid" id="Q2H5N5"/>
    <dbReference type="OrthoDB" id="4842715at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ89411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="230" mass="25695" checksum="474F395BFF16146B" modified="2006-03-21" version="1">MGNRAHRSTELAVRLVVAQVQEAWRQKGAASLLQLDISGAFDTANHTRLLATLREMGYPRWLVLWIRDWLTGREATLLFDGKAATPTAIWAGVPQGSPLSPVLFILYIASLYKQLKDEHPHLAIVGFADDTNLLAFGRNPRGGGTSPVKPEGSARFLGVWLDWKLNWKAHLVAVERKLRTQSYALSRIVAKTWGMGLAKAREVYTKCIRSAAGPMAHHRFTSPRMWEASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5U0</accession>
    <name>Q2H5U0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSm2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_05975</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222070.1">
        <property type="nucleotide sequence ID" value="XM_001222069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5U0"/>
    <dbReference type="FunCoup" id="Q2H5U0">
        <property type="interactions" value="901"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H5U0"/>
    <dbReference type="GeneID" id="4391383"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05975"/>
    <dbReference type="eggNOG" id="KOG3448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130474_3_0_1"/>
    <dbReference type="InParanoid" id="Q2H5U0"/>
    <dbReference type="OMA" id="DNISCTD"/>
    <dbReference type="OrthoDB" id="10256176at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01725">
        <property type="entry name" value="LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000009">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016394">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ89356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="98" mass="11168" checksum="1B9703AE4FACBC1B" modified="2006-03-21" version="1">MLFFSFFKTLIDHEVTVELKNDIQIRGVLKSVDQYLNIKLDNIQVLEEIKYPHMSAVKNVFIRGSVVRYVHLPANAVDVPLLEDATRREAANQAGKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6C1</accession>
    <name>Q2H6C1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sin3 binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221889.1">
        <property type="nucleotide sequence ID" value="XM_001221888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6C1"/>
    <dbReference type="STRING" id="306901.Q2H6C1"/>
    <dbReference type="GeneID" id="4391171"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05794"/>
    <dbReference type="eggNOG" id="ENOG502QW7S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037235_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6C1"/>
    <dbReference type="OMA" id="EDWATMG"/>
    <dbReference type="OrthoDB" id="5391991at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000432">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018818">
        <property type="entry name" value="Stb3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28164">
        <property type="entry name" value="PROTEIN STB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28164:SF1">
        <property type="entry name" value="PROTEIN STB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10330">
        <property type="entry name" value="Stb3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="38906" checksum="BBA3A770E5069FE5" modified="2006-03-21" version="1">MATMASAVRDIAMTSGRDNLTAVAARSVPVTNNPTNPTDLPTPPNSISPSLPPHGLKAQLQRARLDSIDSDLDLLEAGGGHAAGLGSPPYDSSGAITPAMLAKFHLPEILLSHGPLPIRHLMGYLTTSVPGFAGIAPAKARRLVVGALEGKGTGNEGGGLDGDVEFMKVGWGRWDAKRRGQPARGSLSRHASPGAHPNSIPIIKTPGWSTDRLRLGANLGTSQGGYSAAFSHDDRFLDTDMDMMDHEADKMSLDGSGSASCSEAPDDDDEMRRHNDDPEDATDDEDWAAVGAAALRASSYQAQSNQQQFPFNNVHTFGGGIRSVSTGMARPPQLSPSPRNFNFPSSTLGVVAADAQEREAVEALLRLGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6I7</accession>
    <name>Q2H6I7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="4">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_05728</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="4"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221823.1">
        <property type="nucleotide sequence ID" value="XM_001221822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6I7"/>
    <dbReference type="FunCoup" id="Q2H6I7">
        <property type="interactions" value="397"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H6I7"/>
    <dbReference type="GeneID" id="4390099"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05728"/>
    <dbReference type="eggNOG" id="KOG3124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042344_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H6I7"/>
    <dbReference type="OMA" id="VWAVKPQ"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="6">
        <location>
            <begin position="13"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="7">
        <location>
            <begin position="212"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ89109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="332" mass="34373" checksum="58E3C9A674D72A54" modified="2006-03-21" version="1">MSASQDGSSSELTVAVLGCGTMGIAILSGILASISEMQDANIKPSVSGTSTPLYETTTTTRLPSRFIACVRRPESVKKLKATFAAHLSAVTIAQNNNVASVRKADVVILACKPYMVQEVLSEAGLAAALDGKLLISILAGVTESQIESTLAAANDQKPVPCRVVRAMPNTASLIRESMTVIGISNPPLDPDTLGLVTWIFKRIGEVVYLPPSTMDVCTSLCGSGPAFFALMLEAAIDGAVAMGLPRAEAQRMAAQTMKGAAGLVLNGDHPALLRDKVSTPGGCTIGGLLVLEEGRVRGTVARAVREATVVASQLGQGVQGVNGTRFPGSQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7M0</accession>
    <name>Q2H7M0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative gamma-glutamylcyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_05345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221440.1">
        <property type="nucleotide sequence ID" value="XM_001221439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7M0"/>
    <dbReference type="GeneID" id="4390563"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05345"/>
    <dbReference type="eggNOG" id="ENOG502S2U6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092543_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H7M0"/>
    <dbReference type="OMA" id="YAIAKWG"/>
    <dbReference type="OrthoDB" id="4586421at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045038">
        <property type="entry name" value="AIG2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544:SF4">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="5">
        <location>
            <begin position="69"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ88726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="213" mass="23365" checksum="AF40F1C3F0E6A7B3" modified="2006-03-21" version="1">MEESNEPCLGVDKPAPPPPPPPPPPPLPPAPLSQKPPTRKVAAVPNQPTIQAAPPSDGPNPPPFQPTYYFFYGTLTKPHILQGVLGLDSAPTPLHPAQIHHHELTAWGNYRMLIDSSNPEAVVDGYAYHVQFAEEAHKLGYYEPNAYVLTDCTIHFTDPSQGSSSSPPVVEGKTFKYAGDAAALREGRFDRVLWERQMGRPWPLRRQQGGTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7R8</accession>
    <name>Q2H7R8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl transferase family 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221392.1">
        <property type="nucleotide sequence ID" value="XM_001221391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7R8"/>
    <dbReference type="STRING" id="306901.Q2H7R8"/>
    <dbReference type="GeneID" id="4390488"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05297"/>
    <dbReference type="eggNOG" id="ENOG502RYA1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054222_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7R8"/>
    <dbReference type="OMA" id="EEQTHEM"/>
    <dbReference type="OrthoDB" id="512920at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12526:SF510">
        <property type="entry name" value="D-INOSITOL 3-PHOSPHATE GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12526">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="49955" checksum="4333BFA717CDC265" modified="2006-03-21" version="1">MRVFLVQTAHGLNAPSGGYRSNLGFIRQLGAYGHAVAQTCYAWDDEVEAGVAKAKTKGVNPEVQRLPNVDLGQDPKTGIKRRLRVTKFVDENRILNIVISRALWELYPHAEQVADHRAYLEHNLASPRLAALVNLWSSQIAAFKPSHVVFNDGLTMRITQHMLQPGSPYSHMKFKRVCIVHSAEQLPFGPFCGSLSGHCLSAPAENKMLRGLDGIWTVSRGIQDYAMKHGNLKTTFFVHATWTYLEGGNIPMRRNNVDKTEVGLVNACALKGLPIFIELAKRMPHIKFVTWKSWGTKQWHLDQLQQLPNVKVEPSTTDTERDIWDRIKVLLVPSVWNEAWGAVITEAQLRGIPVMASDAGGIPEAKIDLPYLVPVKMVTGEVDAKTGDYVVPPQDIAPWEHALARLMARDTTEYEELSDYTARKTVQWIRGLDQRAQEKWLLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7X9</accession>
    <name>Q2H7X9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_03675</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230191.1">
        <property type="nucleotide sequence ID" value="XM_001230190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7X9"/>
    <dbReference type="GeneID" id="4388721"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03675"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002763_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H7X9"/>
    <dbReference type="OMA" id="WATTERS"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="591"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1063"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="246"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1026"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1038"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ91740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1193" mass="129070" checksum="60E47099775E6AED" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H804</accession>
    <name>Q2H804_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine amidotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230166.1">
        <property type="nucleotide sequence ID" value="XM_001230165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H804"/>
    <dbReference type="STRING" id="306901.Q2H804"/>
    <dbReference type="GeneID" id="4389046"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03650"/>
    <dbReference type="eggNOG" id="KOG3179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054974_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H804"/>
    <dbReference type="OMA" id="NEFWNDV"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="60"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="255" mass="28744" checksum="C4D085D17C80D063" modified="2006-03-21" version="1">MSPTRIQPPLRVAVLLNSYRSPFIAEIRDSYVRSTGAVASDDAELTFFLPAEKPDDFPDPDAFDLIVVGGGNADPRKKHPWILRVHKFILDVVANYPRTKLCGICWGHQTISMLFGAELVDMETPELGVTDAELTPAGSRFFGRENGNGIVRLQQHHRRGVGTPPRGFHELLVGNQAFLSHDRTILTMQGHPEKDAQCAKLRVRDATRWFGLNEDDKVALLRIEKAMDREDDGPEVWARIFEWAREEHPGYGVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H846</accession>
    <name>Q2H846_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="8">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_03608</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Alpha-L-arabinofuranosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the glycosyl hydrolase 62 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="8"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230124.1">
        <property type="nucleotide sequence ID" value="XM_001230123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H846"/>
    <dbReference type="GeneID" id="4389453"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03608"/>
    <dbReference type="eggNOG" id="ENOG502QR18">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041805_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H846"/>
    <dbReference type="OMA" id="WTAPKTF"/>
    <dbReference type="OrthoDB" id="3156236at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08987">
        <property type="entry name" value="GH62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005193">
        <property type="entry name" value="GH62_arabinosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631:SF2">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03664">
        <property type="entry name" value="Glyco_hydro_62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 8 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209037" description="Alpha-L-arabinofuranosidase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ91673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="370" mass="41309" checksum="0F08FB51E79AAB93" modified="2006-03-21" version="1">MRSLSVAVAAFWAGVVCAMPTSDSSTSALAARKPAKPAVLPNKFKWTSTGPLIGPKDDGRDLAGLKDPTIIEIDGTYHVFASTAKAEGYNMMYLNFTSFDEAGSADYYYLDQAPLGVGYRAAPQVFYFAPQKLWYLVYQNDNAAYSTNPDISNPAGWTAPKTFYTARPQIINDNIGPYYWVDMWVICDKKRCHLFSSDDNGHLYRSDTAIADFPEGMSEPVIAMEDPDRYKLFEAACVYAVKGGKGKQQYLMLIEAIGTDSQRYFRSWTSDKIDGKWEPLADTEENPFARANNVEFENGEAWTRSISHGEVIRSLTDQTLTIDVSEPLRFLYQGLDPAKDEGEYNALPWRLALLTQQVEPKPGPGCKPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H891</accession>
    <name>Q2H891_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_03563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230079.1">
        <property type="nucleotide sequence ID" value="XM_001230078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H891"/>
    <dbReference type="GeneID" id="4388765"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03563"/>
    <dbReference type="HOGENOM" id="CLU_3335507_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H891"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ91628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="38" mass="4079" checksum="57249F4D1D65C5E1" modified="2006-03-21" version="1">MGWIIPGVASGNGWTYNVSYNPLFVSYTEGGTQGLELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8C4</accession>
    <name>Q2H8C4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cystathionine gamma-synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_03530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230046.1">
        <property type="nucleotide sequence ID" value="XM_001230045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8C4"/>
    <dbReference type="STRING" id="306901.Q2H8C4"/>
    <dbReference type="GeneID" id="4388523"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03530"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_299754_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8C4"/>
    <dbReference type="OrthoDB" id="441890at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="852"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="645"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ91595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1000" mass="111279" checksum="9B18F6C9667A309C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8Q2</accession>
    <name>Q2H8Q2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229918.1">
        <property type="nucleotide sequence ID" value="XM_001229917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8Q2"/>
    <dbReference type="STRING" id="306901.Q2H8Q2"/>
    <dbReference type="GeneID" id="4389578"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03402"/>
    <dbReference type="eggNOG" id="ENOG502SQ4R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_270324_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8Q2"/>
    <dbReference type="OMA" id="FGDQWAS"/>
    <dbReference type="OrthoDB" id="2426273at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596:SF2">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G17550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="777"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="807"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="969"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="983"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="995" mass="110961" checksum="5B916241BE9A2823" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H931</accession>
    <name>Q2H931_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Probable aspartic-type endopeptidase OPSB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Probable aspartic-type endopeptidase opsB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_03273</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229789.1">
        <property type="nucleotide sequence ID" value="XM_001229788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H931"/>
    <dbReference type="FunCoup" id="Q2H931">
        <property type="interactions" value="277"/>
    </dbReference>
    <dbReference type="GeneID" id="4389522"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03273"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_9_3_1"/>
    <dbReference type="InParanoid" id="Q2H931"/>
    <dbReference type="OMA" id="CNVTLGT"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000011">
        <property type="entry name" value="Aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965:SF12">
        <property type="entry name" value="ASPARTIC PROTEINASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965">
        <property type="entry name" value="ASPARTYL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 12" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase A1" evidence="13">
        <location>
            <begin position="69"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ91338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="492" mass="51825" checksum="653074DD8B4BD709" modified="2006-03-21" version="1">MKPVSLLAIAATLIQRVAVYALLLPRNNDAPRVLSLETQRRTPRNPAHRDKLRKRDTLEVGLDNEETLYFINGTIGTPPRPVRLHIDTGSSDLWVNTPASKLCASGGNPCAYAGTYEANSSSTYEYIASNFNISYVDGSGATGDYVADTVTIGSQRLNRLQFGIGYSSTNAQGILGVGYPLNEVQVNRARLQPYSNLPAQLVAEGVIQSNAYSLWLNDLDANTGNILFGGVDTDKYIPPLQSLPIESTTGVHGEFIITLTNLHLGNRTIGRNSELANPAATGGGNGNSHSNNPLALAVLLDTGSSLTYLPDDLVSELYTLLGAVYNATANAAYIACSAARSPPPNATHLTFTFSAPAIAVPLDELVLDLVTAAGVRPTFADGTPACLFGIAPAGAGTYVLGDTFLRSAYVVYDLENHEIALAPTLFNSTSTRVMEIGRGKGAVPGVTRVANPVKATAGLRGWNASGAVGRRVEGVWKGVVVGVVGVVVLGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H936</accession>
    <name>Q2H936_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_03268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229784.1">
        <property type="nucleotide sequence ID" value="XM_001229783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H936"/>
    <dbReference type="GeneID" id="4389517"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03268"/>
    <dbReference type="HOGENOM" id="CLU_1320758_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H936"/>
    <dbReference type="OrthoDB" id="3797690at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ91333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="208" mass="23763" checksum="CC34924F2CEF8D28" modified="2006-03-21" version="1">MAKDAKFQTDHLFELQIVKMLLRTAYTGGLPKVDKKAATQPIEAPKITEENILTGWHKRYPSNIDLNPVHDPSVKGMPENYRPPENTPADRVMTALGDWGNLQNLVATTGMLSGAPENHKVAAEKIEATFQGIFLVFEYINNPRLEPVWRQAYKGFNQEVVNMDLHMPELKGMKAIWEELWPAYQRVVAQRAYDWVLTTSDMIERDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HA07</accession>
    <name>Q2HA07_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_02947</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229463.1">
        <property type="nucleotide sequence ID" value="XM_001229462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HA07"/>
    <dbReference type="STRING" id="306901.Q2HA07"/>
    <dbReference type="GeneID" id="4388814"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02947"/>
    <dbReference type="eggNOG" id="KOG2808">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039675_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HA07"/>
    <dbReference type="OMA" id="SFAQVRW"/>
    <dbReference type="OrthoDB" id="10261918at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000008">
        <property type="entry name" value="Related to potassium channel regulatory factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="10">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Prp18" evidence="9">
        <location>
            <begin position="246"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="86"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ91012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="393" mass="43407" checksum="0F6D3799E8107001" modified="2006-03-21" version="1">MDFAALMSQEISKSKGDSSSSSSNNKKDPKPTSSSSTTTTDTTTTTTPAHPKYISRREAEAARRAAYLAEQAALEEARAGKAAAKRQREEEAAQEARARDEKRRRLAEESRARRGAREAEEERKRRKRLGLPELPPPSAGAADAATGEGEVSEDGDEDEEAGDVPEEELVKRLRGLGEPAVLFGEGHAARLRRYRKVVRGGALAAASGPIATTLLPVEEKDMKVPDTVPPASDKKARRLLFRQLASYFNMILREWELALAREDNADTFAGQAAHSAMVSSKETMRPLFRKFEQGDLDESILEAVIEIVKAAQERRYVDANDGYLRLSIGKAAWPIGVTMVGIHERSAREKLHGGERGHIMGSEVTRKYLQSIKRCLTFAQVRWPPEDVRQLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HB33</accession>
    <name>Q2HB33_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_02571</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229087.1">
        <property type="nucleotide sequence ID" value="XM_001229086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HB33"/>
    <dbReference type="FunCoup" id="Q2HB33">
        <property type="interactions" value="309"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HB33"/>
    <dbReference type="GeneID" id="4389340"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02571"/>
    <dbReference type="eggNOG" id="KOG3080">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036007_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HB33"/>
    <dbReference type="OMA" id="DAHKGRD"/>
    <dbReference type="OrthoDB" id="443772at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000280">
        <property type="term" value="P:nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="413"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ90636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="427" mass="46416" checksum="DC09F0435073D9A8" modified="2006-03-21" version="1">MAKKGAAQSPKTGPKSKSQITNSKSNKQKGNRRKSNEPAVEKVVDEEWEDESDEEEFEVNGSSANKRKAEGEVDEDSDSDESGDDLHGGIDLAGIDDSDSESELDSDGGPENRDDDDDDDDDEEEEDIDVDELSELDEEDEEQIAAGTRVRQTINNKEGLLAALRRFALNTNPKTVPFAFHQSVVSSKITEESIPSVEDDLQRELAFMNQSLEAARQARTLLRKEGVPFTRPTDFFAETVRSDETMQKVKAKMVEEATAKKASAEARKQRDLKKFGKQVQVQKQQERAKQKRDTLEKINLLKRKRQEGGSSALGATEADDLFDVAVDNELKSAGNSKKRSAGGDSRGPPNAKRQKKDAKFGFGGKKRHAKSGDAMSSGDLSGFNAKRMKSGGRSGGPGGRPGGGGGSGGPKGSKPRLGKSRRQAGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HB51</accession>
    <name>Q2HB51_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_02553</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229069.1">
        <property type="nucleotide sequence ID" value="XM_001229068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HB51"/>
    <dbReference type="FunCoup" id="Q2HB51">
        <property type="interactions" value="961"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HB51"/>
    <dbReference type="GeneID" id="4389098"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02553"/>
    <dbReference type="eggNOG" id="KOG1098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009422_8_1_1"/>
    <dbReference type="InParanoid" id="Q2HB51"/>
    <dbReference type="OMA" id="QRKDKYY"/>
    <dbReference type="OrthoDB" id="1287559at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000004">
        <property type="entry name" value="AdoMet-dependent rRNA methyltransferase SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03163">
        <property type="entry name" value="RNA_methyltr_E_SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028589">
        <property type="entry name" value="SPB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="24"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3381" evidence="12">
        <location>
            <begin position="234"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase SPB1-like C-terminal" evidence="11">
        <location>
            <begin position="533"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="433"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="699"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="513"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="558"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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</entry>
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                <person name="Untereiner W.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
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            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <dbReference type="Proteomes" id="UP000001056">
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    </dbReference>
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        <location>
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        <location>
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        <location>
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        <location>
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    </feature>
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        <location>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50030"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ90550.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBH2</accession>
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        <lineage>
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            <taxon>Sordariomycetes</taxon>
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            <taxon>Sordariales</taxon>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228948.1">
        <property type="nucleotide sequence ID" value="XM_001228947.1"/>
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    <dbReference type="AlphaFoldDB" id="Q2HBH2"/>
    <dbReference type="GeneID" id="4389228"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02432"/>
    <dbReference type="eggNOG" id="ENOG502S4AX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012074_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HBH2"/>
    <dbReference type="OMA" id="FHMCDTG"/>
    <dbReference type="OrthoDB" id="3431704at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000010">
        <property type="entry name" value="Fungal transcriptional regulatory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF28">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="328"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="434"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="621"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="723"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="822"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="726"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ90497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="845" mass="92862" checksum="B5F505BDA6EAEBC9" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBW4</accession>
    <name>Q2HBW4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">laccase</fullName>
            <ecNumber evidence="5">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CHGG_02290</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Lignin degradation and detoxification of lignin-derived products.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="5"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228806.1">
        <property type="nucleotide sequence ID" value="XM_001228805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBW4"/>
    <dbReference type="SMR" id="Q2HBW4"/>
    <dbReference type="GeneID" id="4388576"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02290"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_3_2_1"/>
    <dbReference type="InParanoid" id="Q2HBW4"/>
    <dbReference type="OMA" id="HNGTGIH"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000078">
        <property type="entry name" value="Laccase-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000046">
        <property type="entry name" value="Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF87">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209392" description="laccase" evidence="13">
        <location>
            <begin position="22"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="94"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="215"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="438"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAQ90355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="619" mass="68515" checksum="C7090A133944636C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HC26</accession>
    <name>Q2HC26_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228744.1">
        <property type="nucleotide sequence ID" value="XM_001228743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HC26"/>
    <dbReference type="GeneID" id="4389158"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02228"/>
    <dbReference type="eggNOG" id="ENOG502RMRV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052872_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HC26"/>
    <dbReference type="OMA" id="ATIPQFF"/>
    <dbReference type="OrthoDB" id="5334363at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="376" mass="41848" checksum="AD7EFE99B315FAB9" modified="2006-03-21" version="1">MGKIAVLVVVVATPNSPNFSSTGRPLTETTLSAEKERPGGLALDRIFLPLRSVGAGLPGISVDGLGGIIESAHGVFHSVRRLDFMEAERTMYFMPSPGIEMPQTLHQRDFERYENELFDLSKYNGTSGYLTAMAWTEEALSGSITLYRVLFGEEGETVGIRPVAAMRDVPSPVLARMRTDERIKRKAVVTLIDDDDRTFDWKSNPSTKPRYVRLPSPFQPPSRSHSRHGGGRLADGDGVCATIPQFFALLHARGSILEHVNSAQITETRTEDGSIKPMVFLTQPPRSSPHEGNRVHVAILVPNDALWAEEEIIWTGQNGLAEFRQRQYWDLIKRASRRATSKNRGQGGESNQDRRYSSGSRSRSQTRGRSGSRSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HC53</accession>
    <name>Q2HC53_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_02201</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228717.1">
        <property type="nucleotide sequence ID" value="XM_001228716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HC53"/>
    <dbReference type="SMR" id="Q2HC53"/>
    <dbReference type="STRING" id="306901.Q2HC53"/>
    <dbReference type="GeneID" id="4389445"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02201"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054967_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HC53"/>
    <dbReference type="OMA" id="QRGYRKR"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="204"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="273"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ90266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="320" mass="35231" checksum="2C3799F85D2B75DB" modified="2006-03-21" version="1">MDFDLRLSNTDPIERRRLQNRLAQRKFRLKKAADRAHLHDDPSPAQPETQTRNLILPNQSTIPLSPNDPLRSTSHTILDPNDVDFSQLDVMGSFLPDVGVVGVPMVQARFEPTLDLGFPQDPSHHDSNDGQNPQQGPILPPPLDQILYEVQSDNSLRVLSTAAPEASLDGWVGTLHIAAQGGNEGIVRILLQRGQVDCNEQDSDGRTALMHAVIEGHEAVVRLLLAHAARVGDLDRDRRSALHLAILHRRESILRVLLDCQDPGLDLDAYDVAGWTPLHMAVERGFAVAVELLLQNGANMDTKARKCHLMGRGATGHAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HC98</accession>
    <name>Q2HC98_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_02156</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228672.1">
        <property type="nucleotide sequence ID" value="XM_001228671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HC98"/>
    <dbReference type="GeneID" id="4389334"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02156"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="InParanoid" id="Q2HC98"/>
    <dbReference type="OMA" id="VTCVLVY"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="10"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ90221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="535" mass="58757" checksum="7D4108B61C0241D9" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCE0</accession>
    <name>Q2HCE0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_02114</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001221334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCE0"/>
    <dbReference type="FunCoup" id="Q2HCE0">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HCE0"/>
    <dbReference type="GeneID" id="4386303"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02114"/>
    <dbReference type="eggNOG" id="KOG0186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018202_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HCE0"/>
    <dbReference type="OMA" id="QFCAGEK"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000013">
        <property type="entry name" value="Proline dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF30">
        <property type="entry name" value="PROLINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="6">
        <location>
            <begin position="79"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ93879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="421" mass="45656" checksum="392C332BBCF0CEF2" modified="2006-03-21" version="1">MARPAPLSVLPLTNVLRSLMTTTVSSSPLLLPPSLAMMSILANTSTAVLNPDKNAILRFFLKKTFYAQFCAGENPLEVRRTIESLKTIGLSGVILGYAKEVVLTEAQMKDLASCNTGAAADDCVRTEITPWANGTMETVRLASPGDFVALKFTGAGRQALYVLSQRLEPSEALSSAIDSICQLAAARGVRLLFDAEQQALQPGIDDWSIEYMRKYNTGVNAVVYGTYQAYLKSTPSTISRHLAAAREGGFTLGVKLVRGAYLGSDPRHLIHDTKADTDAAYDGISEALLRGQWSAGLEPPPSKPGEAAAFPSVNLVVATHNRESVVKARKILSETNTGVDVAFAQLQGMADEISCELVTTAADKTPRAYKYLVWGSTGECMKYLLRRAHENKDAVQRTRAGRDAMRVELFRRLKSLFGLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDC2</accession>
    <name>Q2HDC2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221003.1">
        <property type="nucleotide sequence ID" value="XM_001221002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDC2"/>
    <dbReference type="GeneID" id="4386266"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01782"/>
    <dbReference type="eggNOG" id="ENOG502RJ6T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_621119_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HDC2"/>
    <dbReference type="OrthoDB" id="5236983at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48148">
        <property type="entry name" value="KERATINOCYTE PROLINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48148:SF2">
        <property type="entry name" value="PA14 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="441" mass="46645" checksum="4220641981821ACF" modified="2006-03-21" version="1">MTIFGTNGRNTFNKLSLPAPSPSKRLSRYSTTTRRFTTPIHSIRIIIIITIRATHLTATLLRDLMFPHPSQPAPLPPRRWNAPPPATPSARTQPRVSAGATQTPSTSAFSGVSSTRGPGATPTQAATPTATPTPALTLIPALTPTPAPTPTPATPITISPTTVPTPTTSTTSPPPPQPATPPPATTTPNPEDAEYPLDNDALESIFSAANEIFFNGRLSQRVAWDWSHASSSRYDSRVIGTTALRRAAAHTRGFETLIVLSASILRGGGFSRRLLIKGEKGVEWGSGSGWGQVWGAPPNVYPCSGMAAEQEEYAAAPGSAAAVAAFPGPVTQEMVYFGTGGGGNVPVAGQEAVHYARGSPSPRPGTPTREMVYFGRGSPSPRPGTPTREMVQYGDRGLSSSGSNGSNVWWRHRRAGRPLYVYSGDKPSPSYVYTHPTGQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDF9</accession>
    <name>Q2HDF9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220966.1">
        <property type="nucleotide sequence ID" value="XM_001220965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDF9"/>
    <dbReference type="STRING" id="306901.Q2HDF9"/>
    <dbReference type="GeneID" id="4386783"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01745"/>
    <dbReference type="eggNOG" id="ENOG502R9QP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_621405_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HDF9"/>
    <dbReference type="OrthoDB" id="5232052at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="498" mass="55766" checksum="76238366B58B3243" modified="2006-03-21" version="1">MTYQNYEGFYPPGLPPRQPLEARSSSVSSTSSSASYSVPYDAAATHNVGISRTVSPASGVSDLETDSVLYSRNQFSTLAQEHTPTSGVSGSGEGGVIYSRNHYQTLGHEHQSPFRSHATPLPSQLLQAQATSSHPFYSAFQAPRQILPLPPYSGYSVGALHPQSTSLHQQPTSLDHQSPSLYRQPSSLHHQTSSLHHQPSSLHYQPSPLHYESWPQDCAPTPYHSLPTPPSHQLPPQNQPRAKSATLDEPAPLLRFLQQLSPAIILQIQEEVTWFHCWKLYRTNRWFRVNFHPDRLPDHLKIGGLLSAEKNEGREDPEESDTPRTTKPRKNFNFFGCYHCYRFRGFEYFESQKYGVLATQGDGRDGGAEREQSYTPPPSKSSSLSPPANPHYDPSLTRSSLRASAAAKGRRTSTSPAGDTFSTSHARARKTSEQRRFCVDCGLRKEFYKPRDVIDLHRPLNKGNALWVCDCRKLRHRLTEGKCYDCDATVPYSIPVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDV4</accession>
    <name>Q2HDV4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF2406 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220821.1">
        <property type="nucleotide sequence ID" value="XM_001220820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDV4"/>
    <dbReference type="GeneID" id="4386424"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01600"/>
    <dbReference type="eggNOG" id="ENOG502RXHE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037541_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HDV4"/>
    <dbReference type="OMA" id="RFPQDSY"/>
    <dbReference type="OrthoDB" id="5330253at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018809">
        <property type="entry name" value="DUF2406"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28186">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28186:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10295">
        <property type="entry name" value="DUF2406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="34249" checksum="F01CB689807D8FB0" modified="2006-03-21" version="1">MQEAEPSAVATTVKSSLASLRSIQHKDVFGNPIPEPDRSNPTRSRWERPLDTIRSFEAAIDGGYNNRRSIIRPDGNGGRFNHDSYYGSRPPSMMYTNRADSSLPDLRSSGMGQRDSYYEQQPGYGGYGGPAPNGRRGWPRMASEPYYGASYRQQQHQHQHQQQMDYSLPSNHRSYETVTTAAGSGSSAEPAGYHTDPTSSDNSSVERVQSSVPRRQPEPVNDYVIGFSQSPSYQGASFALSTGGGGGDGHNNNNYQAGGAHGHGNPPPPVPRKDVGGTLRKPVSNPIHQAHQAPPAQPEKRKSWFARRFSKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDX9</accession>
    <name>Q2HDX9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TUG ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220796.1">
        <property type="nucleotide sequence ID" value="XM_001220795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDX9"/>
    <dbReference type="FunCoup" id="Q2HDX9">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HDX9"/>
    <dbReference type="GeneID" id="4387246"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01575"/>
    <dbReference type="eggNOG" id="KOG2699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_534160_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HDX9"/>
    <dbReference type="OMA" id="APKYDWG"/>
    <dbReference type="OrthoDB" id="440781at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16105">
        <property type="entry name" value="Ubl_ASPSCR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021569">
        <property type="entry name" value="TUG-UBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467:SF1">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11470">
        <property type="entry name" value="TUG-UBL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TUG ubiquitin-like" evidence="2">
        <location>
            <begin position="8"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="552" mass="59268" checksum="70E8153FA5218B1E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEJ7</accession>
    <name>Q2HEJ7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220578.1">
        <property type="nucleotide sequence ID" value="XM_001220577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEJ7"/>
    <dbReference type="STRING" id="306901.Q2HEJ7"/>
    <dbReference type="GeneID" id="4386617"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01357"/>
    <dbReference type="eggNOG" id="KOG0259">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_4_1"/>
    <dbReference type="InParanoid" id="Q2HEJ7"/>
    <dbReference type="OMA" id="IMAARDY"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510:SF1">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="1">
        <location>
            <begin position="57"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="406" mass="44051" checksum="07E745EF80F318A9" modified="2006-03-21" version="1">MVKIEPFEVEQWMDRLETTPGVLNIAETCAASVSVDDLVRMCEDKDAPGPLSLSKKLTYGAIRGSENLRQRVAALYDRASDAEPLPAENVIITQGAITANFLTFYTLVGPGDHVICVYPTYQQLYSVPESLGAEVSLWKLKKENGYIPDVAELEGLVKDNTKLIVINNPNNPMGSTIPTTTLAQIVSFAQQRSITILSDEVYSPLYHSLPANQPAPPSILTFGYAQTIATGSMSKAFALAGIRTGWIATRDPRIADAVAAARDYTTISVSQLDDQVAGYALSPAVVQPLLARNMALARANLALLSAFVEKYAAVCAWTKPTAGTTALVQFRDLKEGGAPVDDARLVMDVLEKTKVLVMPASPCFGLGKDFKGFVRMGYVCETEVLVEGLERLGRYIEEYLMGEGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEN0</accession>
    <name>Q2HEN0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Superoxide dismutase copper/zinc binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220545.1">
        <property type="nucleotide sequence ID" value="XM_001220544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEN0"/>
    <dbReference type="STRING" id="306901.Q2HEN0"/>
    <dbReference type="GeneID" id="4387243"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01324"/>
    <dbReference type="eggNOG" id="ENOG502S5NX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063073_1_2_1"/>
    <dbReference type="InParanoid" id="Q2HEN0"/>
    <dbReference type="OMA" id="QGPFKYH"/>
    <dbReference type="OrthoDB" id="159229at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209419" description="Superoxide dismutase copper/zinc binding domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="16442" checksum="7214ABBC72B27A8E" modified="2006-03-21" version="1">MQLISLFALLGAAAVAVGQVTGPNVTTGALGDAKEVRNNPVIGETWVSTFNSDAVRGTVKAVAHTVGINYTLDVTGLVVDKGPYKYHIHVRATPESGNCTETGGHLDSFNDKYTALNPIQLGYIGDRSIVFHDNTGARIACATLKKVEKDDDTCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEP7</accession>
    <name>Q2HEP7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220528.1">
        <property type="nucleotide sequence ID" value="XM_001220527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEP7"/>
    <dbReference type="GeneID" id="4388333"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01307"/>
    <dbReference type="HOGENOM" id="CLU_3406317_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HEP7"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="30" mass="3425" checksum="D2C5515D4A27EDF7" modified="2006-03-21" version="1">MLNVASPYRSGKWQLPTKPLRRRAAAKIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HF32</accession>
    <name>Q2HF32_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_01172</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220393.1">
        <property type="nucleotide sequence ID" value="XM_001220392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HF32"/>
    <dbReference type="STRING" id="306901.Q2HF32"/>
    <dbReference type="GeneID" id="4386519"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01172"/>
    <dbReference type="HOGENOM" id="CLU_1170527_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HF32"/>
    <dbReference type="OrthoDB" id="5095382at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="156"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ92937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="237" mass="26152" checksum="3234D02E61A481B6" modified="2006-03-21" version="1">MVIDECWERPWMRFRSRTPRRRPLHAIQDPLGNGFTAVRIQPANDFHGCCSMGKTKDSSVTATIQGRQANLSSAHDDGPHGSPQRHIHRDGGSADEVGLGGQMQLEFGRYATYVDVAFGLTRHWTLNKLQSLAVLIPAAFLDDRGTRLQEEGGWQHFQYVGGEGGTGKSRVIHAIHDMFRLKDGLHTLLLTGASGNAAALIGGVTLHSATNIGFEGKNEVARNISEEEKLRWKIWSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFD2</accession>
    <name>Q2HFD2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="8">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_01072</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="8"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220293.1">
        <property type="nucleotide sequence ID" value="XM_001220292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFD2"/>
    <dbReference type="FunCoup" id="Q2HFD2">
        <property type="interactions" value="282"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HFD2"/>
    <dbReference type="GeneID" id="4386508"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01072"/>
    <dbReference type="eggNOG" id="KOG0366">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028946_3_0_1"/>
    <dbReference type="InParanoid" id="Q2HFD2"/>
    <dbReference type="OMA" id="VKRCQCP"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000009">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="9">
        <location>
            <begin position="16"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ92837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="327" mass="35970" checksum="7D8AE1B8BF355C75" modified="2006-03-21" version="1">MSQTLNQLPEEPQLAAPAHVKYIQSLDSRKDEYDYWLTEHLRLNGLYWGLTALHLLGQPDALPRAETIDFVLSCQHENGGFGAAPGHDAHMLSTVSAVQILATVDAFDELETRGKGKAQVGQYIANLQNRETGTFAGDEWGEEDTRFLYGAFNALSLLGLLNLVDVEKAVNHIAACANFDGGYGVSPGAESHSGQIFTCVAALTIAGRQDLVDKERLGRWLSERQIAGGGLNGRPEKKEDVCYSWWVLSSLEMIGKTHWIDKDQLVAFILRCQDPERGGIADRPGDMVDVWHTVFGLAGLSLLQYPGLQPVDEVYCMPKSTTRRVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFF1</accession>
    <name>Q2HFF1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220274.1">
        <property type="nucleotide sequence ID" value="XM_001220273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFF1"/>
    <dbReference type="GeneID" id="4386791"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01053"/>
    <dbReference type="HOGENOM" id="CLU_1959307_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HFF1"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="128" mass="13838" checksum="3F8F9E1DE02A2B18" modified="2006-03-21" version="1">MYHKIQLPRPAQSLRKTIQRGTEHALFGGLAQAQGDGDPRRGKFDAGLPARRPRRTLKRVSPTHSKGVFGRNISACAAIAAAVIARDTLPTYTAGETWDVRPWRHPSCATALPSIPRPAPGRRAASAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFL4</accession>
    <name>Q2HFL4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Manganese/iron superoxide dismutase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_00990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220211.1">
        <property type="nucleotide sequence ID" value="XM_001220210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFL4"/>
    <dbReference type="FunCoup" id="Q2HFL4">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HFL4"/>
    <dbReference type="PeroxiBase" id="13888">
        <property type="entry name" value="CgFSD01"/>
    </dbReference>
    <dbReference type="GeneID" id="4386400"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00990"/>
    <dbReference type="eggNOG" id="KOG0876">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057349_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HFL4"/>
    <dbReference type="OMA" id="MTAREPN"/>
    <dbReference type="OrthoDB" id="275227at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="3">
        <location>
            <begin position="132"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="3">
        <location>
            <begin position="256"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ92755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="336" mass="36513" checksum="80E6B374F26C52BE" modified="2006-03-21" version="1">MLRPGLRIAMRPRVGAPARSTLLPLACQARSMHALAPLSYDLKGEATQNGISDFLSPAAFNISWTQYQTYLLQKLNILTAETDYESHQIKDILLGTARDPGSAPIFNHASMAHNNHFFFKHISPKPVEVPEPLRSRLEQSFGSMDTLRQEMVYTAAGMFGPGFVWLVKTSQPGLPVSFKVLTTYAAGSPYPAAHWRRQEHDMNTAAGSGTEAGIATGRAYLDQTAYGTGSSSRWGSGGPGSATARRVAHAPGGTDLVPVLCINTWEHVWLWDYGFGVGAPDRGKLGYAEKWWKHVDWELVQKEADLQRLEMSANAGAPAPSLSSPSLSSPAPVPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG13</accession>
    <name>Q2HG13_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_00841</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220062.1">
        <property type="nucleotide sequence ID" value="XM_001220061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG13"/>
    <dbReference type="STRING" id="306901.Q2HG13"/>
    <dbReference type="GeneID" id="4387987"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00841"/>
    <dbReference type="eggNOG" id="KOG1443">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_502468_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HG13"/>
    <dbReference type="OrthoDB" id="18894at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="451"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="286"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="101"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ92606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="542" mass="59186" checksum="7C54281601E38E24" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGW2</accession>
    <name>Q2HGW2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_00542</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219763.1">
        <property type="nucleotide sequence ID" value="XM_001219762.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HGW2"/>
    <dbReference type="ESTHER" id="chagb-q2hgw2">
        <property type="family name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="GeneID" id="4388075"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00542"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_6_0_1"/>
    <dbReference type="InParanoid" id="Q2HGW2"/>
    <dbReference type="OMA" id="YCRGDGC"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000002">
        <property type="entry name" value="Probable polyketide synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.110:FF:000001">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030918">
        <property type="entry name" value="PT_fungal_PKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04532">
        <property type="entry name" value="PT_fungal_PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01294">
        <property type="entry name" value="PKS_PP_betabranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="8">
        <location>
            <begin position="390"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="9">
        <location>
            <begin position="1309"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1654"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1794"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1309"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1467"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1736"/>
            <end position="1794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1868"/>
            <end position="1919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1751"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1764"/>
            <end position="1775"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="5">
        <location>
            <position position="1341"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="5">
        <location>
            <position position="1528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ92307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="2181" mass="239317" checksum="38624D2FEFA41E5F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-06-10" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH52</accession>
    <name>COG6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Conserved oligomeric Golgi complex subunit 6</fullName>
            <shortName>COG complex subunit 6</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>Component of oligomeric Golgi complex 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">COG6</name>
        <name type="ORF">CHGG_00452</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COG6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219673.1">
        <property type="nucleotide sequence ID" value="XM_001219672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH52"/>
    <dbReference type="SMR" id="Q2HH52"/>
    <dbReference type="FunCoup" id="Q2HH52">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HH52"/>
    <dbReference type="GeneID" id="4387544"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00452"/>
    <dbReference type="eggNOG" id="KOG3758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011361_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HH52"/>
    <dbReference type="OMA" id="HSCLDFF"/>
    <dbReference type="OrthoDB" id="272987at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048369">
        <property type="entry name" value="COG6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048368">
        <property type="entry name" value="COG6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
        <property type="entry name" value="COG6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06419">
        <property type="entry name" value="COG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01087">
        <property type="entry name" value="COG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000339319" description="Conserved oligomeric Golgi complex subunit 6">
        <location>
            <begin position="1"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="690" mass="76737" checksum="716EDE01AB3955BC" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHT1</accession>
    <name>Q2HHT1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_00223</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219444.1">
        <property type="nucleotide sequence ID" value="XM_001219443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHT1"/>
    <dbReference type="GeneID" id="4387238"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00223"/>
    <dbReference type="eggNOG" id="ENOG502SING">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031730_4_2_1"/>
    <dbReference type="InParanoid" id="Q2HHT1"/>
    <dbReference type="OMA" id="WEYIREI"/>
    <dbReference type="OrthoDB" id="6038816at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209266" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="20"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="20"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ91988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="259" mass="28423" checksum="D837AD1609FD4828" modified="2006-03-21" version="1">MRLYLETILAAALAPGALGHQIMGILLVNGTETLEWKYVRDVGYHEAYGPDSYPPGNEFPKTPPQMDINHPDITCGRSAFDSAAKTETADVVAGSEIGFRVSWDGNGKYGVFWHPGPAQVYLSQAPDGELETYKGDGDWFKIAYGGPVGNNEWMVWGAHDFNFTVPETTPPGKYLMRIEQWMPTHMSNYSQWYVNCAHVNVIGPGGGTPAGFAKFPGTYVVDDPGLKIPVNQFVNGGYVPDDEMRLLEYKAPGPVVWTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI88</accession>
    <name>Q2HI88_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_00066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219287.1">
        <property type="nucleotide sequence ID" value="XM_001219286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HI88"/>
    <dbReference type="GeneID" id="4386581"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00066"/>
    <dbReference type="eggNOG" id="ENOG502SW3V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065409_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HI88"/>
    <dbReference type="OMA" id="KKITHFR"/>
    <dbReference type="OrthoDB" id="5426604at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ91831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="32590" checksum="E36E6104A31DF625" modified="2006-03-21" version="1">MSASGVAAAINPNGPEGQQIHLFYNTNTKNLGFQFFDETKHTDETEAFAAGADGQTGFIINPAQVATTNLTGVELVVGFTNKLPAAAANDCKCDDPTQNDVSIISPVYQPLAATDLTNLTIAAVSSDTTAYVYYLTGTDYKSTTINELTVGDDSPGQFDDTVKILAQSSLAAFYVPEDEKRYIIYQAYSTKRLHAYCPIAGSIDDKEIDNSGDARPNTPLAAAYVNGKAYVYYVDTTQSIRVVVRDDTVTSPAWSSSRAVQAPSQVDDASQITVVPSPKGNHIFYVGVGQGKQFKFHHAIDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI94</accession>
    <name>Q2HI94_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Fumarylacetoacetase</fullName>
            <ecNumber evidence="3 13">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_00060</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="3 13"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219281.1">
        <property type="nucleotide sequence ID" value="XM_001219280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HI94"/>
    <dbReference type="STRING" id="306901.Q2HI94"/>
    <dbReference type="GeneID" id="4387068"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00060"/>
    <dbReference type="eggNOG" id="KOG2843">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026207_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HI94"/>
    <dbReference type="OMA" id="QGLEMNP"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF5">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="15">
        <location>
            <begin position="14"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="14">
        <location>
            <begin position="162"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAQ91825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="440" mass="47713" checksum="9BF96E0199312326" modified="2006-03-21" version="1">MTSPNYAHHFSARNIPFGIASSTKHPQPQAVTRVGNSVIFLHECHTSSELFEGIDGLPRRIFADETLNHFAALPKATHRNVRGAIQSVCQNGNLDISKLLPGCVEDITEVEMHMPITVGDFAGTIPLRPPPIIQARLLTTPDFSCSLIHGKNAGRIVVNDPRPPPAFFHFPIAYQGRASSVVVSGTDIERPQGQYRDKSVPTTADEPKPVVYGPSNAVDYELEFAAIIGKPLRMGRRLNAVDADDHIFGFVILNDWSARDIQAFEMTPLGPFNGKNFGTSISPWIVTLDALEAFKTEGQKPMVDIPKYLQDPELRTYAIQMQVELLSGSTPTLAGTSWVQSLYWSPRQMVAHAVSAGAALRPGDIMATGTVSGDGEDASGCMLELTEGGAKPFKLKDGTERGYLNNGDVVRMTAVAGSEESGVGFGECIGRLVESRPMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-10-17" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q0C721</accession>
    <name>Q0C721_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_11118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH670334">
        <property type="protein sequence ID" value="EAQ82859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230270.1">
        <property type="nucleotide sequence ID" value="XM_001230269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q0C721"/>
    <dbReference type="GeneID" id="4397410"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_11118"/>
    <dbReference type="HOGENOM" id="CLU_000680_25_1_1"/>
    <dbReference type="InParanoid" id="Q0C721"/>
    <dbReference type="OrthoDB" id="5082906at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ82859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="17294" checksum="46E3BE96A2523D04" modified="2006-10-17" version="1">MRGAQILQPGLSSPRCSDIDHQQETLFRNETLRRHDGLSKAKSSLLIQIRTGAIGLRDFLFTRGVPEVLTPACECGEGRETAEHLVVWCLAPPLTRRWERTGIWTRRDFYSVLHGINPTTARLARRVLDWLMDSGKLPMYNLARRLELEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GME8</accession>
    <name>Q2GME8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2005-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Giovannoni S.J."/>
                <person name="Cho J.-C."/>
                <person name="Ferriera S."/>
                <person name="Johnson J."/>
                <person name="Kravitz S."/>
                <person name="Halpern A."/>
                <person name="Remington K."/>
                <person name="Beeson K."/>
                <person name="Tran B."/>
                <person name="Rogers Y.-H."/>
                <person name="Friedman R."/>
                <person name="Venter J.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 148.51</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2006-02" db="EMBL/GenBank/DDBJ databases">
            <title>Annotation of the Chaetomium globosum CBS 148.51 Genome.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Birren B."/>
                <person name="Lander E."/>
                <person name="Galagan J."/>
                <person name="Devon K."/>
                <person name="Nusbaum C."/>
                <person name="Ma L.-J."/>
                <person name="Jaffe D."/>
                <person name="Butler J."/>
                <person name="Alvarez P."/>
                <person name="Gnerre S."/>
                <person name="Grabherr M."/>
                <person name="Kleber M."/>
                <person name="Mauceli E."/>
                <person name="Brockman W."/>
                <person name="Rounsley S."/>
                <person name="Young S."/>
                <person name="LaButti K."/>
                <person name="Pushparaj V."/>
                <person name="DeCaprio D."/>
                <person name="Crawford M."/>
                <person name="Koehrsen M."/>
                <person name="Engels R."/>
                <person name="Montgomery P."/>
                <person name="Pearson M."/>
                <person name="Howarth C."/>
                <person name="Kodira C."/>
                <person name="Yandava C."/>
                <person name="Zeng Q."/>
                <person name="Alvarado L."/>
                <person name="Oleary S."/>
                <person name="Untereiner W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 148.51</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226123.1">
        <property type="nucleotide sequence ID" value="XM_001226122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GME8"/>
    <dbReference type="STRING" id="306901.Q2GME8"/>
    <dbReference type="GeneID" id="4397340"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10856"/>
    <dbReference type="eggNOG" id="ENOG502S3FG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_567575_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GME8"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF2">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="47399" checksum="4E127C3377ECFE3D" modified="2006-03-21" version="1">MGQDRLTSAGLLIGCATRILLDPDTIQHGTQDQDGQRMGLALMSCFLVDTILSVRCSRPPHLRAEDLATLPMASENGPDQWEPWTPCEGFGPGNVGSNSSRSPAFRLSTFNQLYAIVKVVAEERTMRRQGSMPRGAPNAFATQLQQAIDPSLPISNFVISQACGTISVPTPYLVRATYLWARALAEPRTETPLLLLHDTLGQYQRQFGRSSTPPFLSACIASLANEEYVLRSGGQNQDLLQRLVTGFSSREPAARRASSVRGPRLDALSRPTQDTLESLNSAHSSAPSNPLMDYAEPSIPLLYNTLATRHRRQSDSRNRVYGSFLSPGMGLYQNSFPNTSMPIPQGSDMHAHHPGGTGMATMPGISTTAASTQRDLHPSYPLIPPTGLGPSPDVDALLDDLAAIEYTDAVDVDSQFMTNLGFAPGCDITEILTRGFGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMQ6</accession>
    <name>Q2GMQ6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ82930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226015.1">
        <property type="nucleotide sequence ID" value="XM_001226014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMQ6"/>
    <dbReference type="STRING" id="306901.Q2GMQ6"/>
    <dbReference type="GeneID" id="4397217"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10748"/>
    <dbReference type="eggNOG" id="ENOG502T38Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082760_2_2_1"/>
    <dbReference type="InParanoid" id="Q2GMQ6"/>
    <dbReference type="OMA" id="YTTIARM"/>
    <dbReference type="OrthoDB" id="2567457at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846:SF5">
        <property type="entry name" value="CARBOXYMUCONOLACTONE DECARBOXYLASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ82930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22727" checksum="B2A8AA82936EB05B" modified="2006-03-21" version="1">MSAPTKTQNCLVPYVDIDAVPAEVAAAITHLPYRRNIFYLLGHSHGSFPRLMSVYANFFDGTRRILPLLDWQLVVLRISAALDAEYEWDVNAPVARINGMPEEKFAALKRSAGGGAEALAKEASFTERDRAILQLVDEQLATYTNTEKTVQQAKKLMTVEELVEVYIVLGVYALIARITKGLRIDLDGEIPGLEEHLNKVVTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMR4</accession>
    <name>Q2GMR4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_10740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ82922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226007.1">
        <property type="nucleotide sequence ID" value="XM_001226006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMR4"/>
    <dbReference type="GeneID" id="4397261"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10740"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_23_2_1"/>
    <dbReference type="InParanoid" id="Q2GMR4"/>
    <dbReference type="OrthoDB" id="3059164at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
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        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="5">
        <location>
            <begin position="694"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="58"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="26"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ82922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1279" mass="142373" checksum="E254C39E66931A57" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNR1</accession>
    <name>Q2GNR1_CHAGB</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228320.1">
        <property type="nucleotide sequence ID" value="XM_001228319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNR1"/>
    <dbReference type="GeneID" id="4396253"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10393"/>
    <dbReference type="HOGENOM" id="CLU_2468863_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNR1"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ83989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="88" mass="9492" checksum="E157AAAA639CC5B8" modified="2006-03-21" version="1">MAILSNDGHGKGGSHAEYREHKVLSMGFKAWLAINTLKARALGGQCWICSPRWGFTACRSSVKGPTALVDRITVGPPGAEPGWRWLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNS0</accession>
    <name>Q2GNS0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chorismate synthase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228311.1">
        <property type="nucleotide sequence ID" value="XM_001228310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNS0"/>
    <dbReference type="STRING" id="306901.Q2GNS0"/>
    <dbReference type="GeneID" id="4397034"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10384"/>
    <dbReference type="eggNOG" id="KOG4253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044758_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GNS0"/>
    <dbReference type="OMA" id="YFYYALP"/>
    <dbReference type="OrthoDB" id="4218123at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470:SF1">
        <property type="entry name" value="CHORISMATE SYNTHASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="39643" checksum="38B3388BEC06849D" modified="2006-03-21" version="1">MAIPWGTIKSLVIFFGPLLLPKAIGYYRRMRDAPRIHGLKVRPLPAPMTRAIAILFAVAAVFLLRTLPIFSPENIFKITQSRLQIPADVLFNRLSALRPSNTLTATDLALRAKFASLESRLLYLHHGPSVVATCPFCTSDDPRSYLYYALPDLLAPHLFNLIIIALATSSLLTGRANSASAARFRAPASLAAVAAAFLDLYWVATYNHTANARALRLGELDAFFWTARVVRYTAVAIVDCLLALVLYLSGTQRAFVNPPSAVERVEAVTRRLGTIMGVVNASGVVKNTVLRDEELRGRSVAYWAHEVRLMREMMEEREVVEGVNDALLNRIDIRGIERDAEAYAKAVLMPAGAGKEQVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPH0</accession>
    <name>Q2GPH0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_10134</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228061.1">
        <property type="nucleotide sequence ID" value="XM_001228060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPH0"/>
    <dbReference type="GeneID" id="4395957"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10134"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GPH0"/>
    <dbReference type="OMA" id="NWAVTRI"/>
    <dbReference type="OrthoDB" id="5667at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF224">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="248"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ83730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="438" mass="46665" checksum="73AF2A7EA6967791" modified="2006-03-21" version="1">MEDPKEKAAPSSSSAETLPAQPRPPTSAPTSPSGPSPPPDGGFKAWSAVLGAWCCLFVSFGWVNCIGIFEAHYQHNQLSEYPPGIVAWITSTEVAVMYISMPVLGKLYDSFGPKPLLYAGTFAHVFGLMMASLATEYYQIMLSQSICSAVGAAAVFSAATGSVGSWFSKRRALALGIVASGSSVSACILPILVIRVGALIGFAWALRICAFMFLFLLIIACFTLESRNPPKPTPWELMAFFRPLGETPFLLNALGLAFFSGGMFVAFNFLVLEAQHRGMGSELANYQIAILNGVSVFGRIIPGWLGDKVGRFNVMVVTTALSAVAVLAIWIPAPIGSTATTVVFACIFGFTSGTFVGMTPALVQQMSRIEEMGIRLGTTFGIISIAALTSNPIAGGLISRNDGGYLYLKIFSGLALTVGSVLILLSRNAQCGWKWKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPH4</accession>
    <name>Q2GPH4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228057.1">
        <property type="nucleotide sequence ID" value="XM_001228056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPH4"/>
    <dbReference type="GeneID" id="4395953"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10130"/>
    <dbReference type="eggNOG" id="ENOG502SMZU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108995_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPH4"/>
    <dbReference type="OMA" id="GFHESAM"/>
    <dbReference type="OrthoDB" id="3450745at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208453" evidence="1">
        <location>
            <begin position="17"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="213" mass="22889" checksum="7E0863D5C909B4E2" modified="2006-03-21" version="1">MHVQSLLLACVAPALALCGPPKPLPPCDTKYRPCRCPAGATFKNLTSYGVIGAPATEVRNIMGKFLNIEFQGGLIPASTTGQEGVPGASRTFNFSAPAGGFYQITEVLVKYKEYPDGSFVNMNQQDPKTPVVAIPGGGTYMGQWSEIVGEQTLIANETVVAWRNWRCETGETFPAAHSHEEGIRNASAVIAAAGKHTGVDIAPFTIWYEERQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPN0</accession>
    <name>Q2GPN0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_10074</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228001.1">
        <property type="nucleotide sequence ID" value="XM_001228000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPN0"/>
    <dbReference type="FunCoup" id="Q2GPN0">
        <property type="interactions" value="509"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GPN0"/>
    <dbReference type="GeneID" id="4396625"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10074"/>
    <dbReference type="eggNOG" id="KOG1607">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028277_4_0_1"/>
    <dbReference type="InParanoid" id="Q2GPN0"/>
    <dbReference type="OMA" id="THAAEFK"/>
    <dbReference type="OrthoDB" id="3053196at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF11">
        <property type="entry name" value="CERAMIDE SYNTHASE LAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="11">
        <location>
            <begin position="162"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ83670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="369" mass="42188" checksum="288C5155F7819AD8" modified="2006-03-21" version="1">MATTEAFSLLSSSTSPFDTTTTTHNGRPSRQRIKSNSQRLPSMPHVQTRPGQLAKPDKRLRRRKRSRGYLRGLLQRTWAIPLGLIFGFLGLYAFNPTESNVVHHFLFLSYKLDDGQYGKGPWDFAFVGFYTIFLTFTREFIMQEVLRPLARLGGIKSKAKQARFMEQMYTACYFAFSGPLGLYTMKQTPGLWYFKTRPMYETYPNLAHDGIFKFYYLFQAAYWVQQAIVMVLGQEKPRKDFRELIGHHIITISLIFLSYRFHFMYIGISIYITHDISDLFLAAVTFALCIAAWIYLRHYLNLTILYSLATEYAVVGPLALDWAAQEYKCRGAQAATFALLAALQGLNLVLAVLLVSERLSLCGVGGREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPP2</accession>
    <name>Q2GPP2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="6">5.3.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phosphohexomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Phosphomannose isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_10062</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="6"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227989.1">
        <property type="nucleotide sequence ID" value="XM_001227988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPP2"/>
    <dbReference type="STRING" id="306901.Q2GPP2"/>
    <dbReference type="GeneID" id="4396582"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10062"/>
    <dbReference type="eggNOG" id="KOG2757">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_450534_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPP2"/>
    <dbReference type="OMA" id="FECHCEL"/>
    <dbReference type="OrthoDB" id="6605218at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF4">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="14">
        <location>
            <begin position="5"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="571"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ83658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="606" mass="67891" checksum="263B2200ABCC6399" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQ03</accession>
    <name>Q2GQ03_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_09951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227878.1">
        <property type="nucleotide sequence ID" value="XM_001227877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQ03"/>
    <dbReference type="STRING" id="306901.Q2GQ03"/>
    <dbReference type="GeneID" id="4396273"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09951"/>
    <dbReference type="HOGENOM" id="CLU_956565_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQ03"/>
    <dbReference type="OMA" id="CERAGHY"/>
    <dbReference type="OrthoDB" id="4903265at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718">
        <property type="entry name" value="OS01G0519700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718:SF3">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="2">
        <location>
            <begin position="229"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="297" mass="33615" checksum="7186C96E75429317" modified="2006-03-21" version="1">MADDGSSGPHPVDQPPEAPLESPQVPGDGFDSFEELFEYINQWAKPRGYAIIILRSSDRQDGRPRRYDLCCDIGGPHHDSSSTGLRKASSKKRDCPWLAKAVQRKLLGDRWYFEVRSDHHNHEPSLDPSAHTAHRKRAWTKEQKEEIRQVFKTTTSGSRDVASFMREKYPSQIWTRRDIENEMSKAKAEALGGYTPTQALLKHFTDTGSNTAFANFKVVSLLLFGPTPFMPFLNVTGITNIHTTFNVAFGVVNKEDEDVYQWLIQMLDELREDAGACRPSVTITDFERALKNALSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQR6</accession>
    <name>Q2GQR6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_09688</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227615.1">
        <property type="nucleotide sequence ID" value="XM_001227614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQR6"/>
    <dbReference type="FunCoup" id="Q2GQR6">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GQR6"/>
    <dbReference type="GeneID" id="4396687"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09688"/>
    <dbReference type="eggNOG" id="KOG1984">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004589_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GQR6"/>
    <dbReference type="OMA" id="INPFMTF"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="12">
        <location>
            <begin position="311"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="13">
        <location>
            <begin position="390"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="15">
        <location>
            <begin position="643"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="14">
        <location>
            <begin position="739"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="11">
        <location>
            <begin position="871"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1007"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAQ83284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1030" mass="111987" checksum="D08D3A2C6AE20C78" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQU1</accession>
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        <submittedName>
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    </protein>
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        <name type="common">Soil fungus</name>
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            <taxon>Sordariomycetidae</taxon>
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        </lineage>
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                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the FMO family.</text>
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        <property type="protein sequence ID" value="EAQ83259.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001227589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQU1"/>
    <dbReference type="GeneID" id="4396758"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09663"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019225_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GQU1"/>
    <dbReference type="OMA" id="KQYHVTH"/>
    <dbReference type="OrthoDB" id="2915840at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ83259.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="542" mass="59772" checksum="AC0B39C606E7AD42" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GS31</accession>
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        <recommendedName>
            <fullName evidence="5">Vacuolar membrane protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">CHGG_09223</name>
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    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227150.1">
        <property type="nucleotide sequence ID" value="XM_001227149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GS31"/>
    <dbReference type="FunCoup" id="Q2GS31">
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    </dbReference>
    <dbReference type="STRING" id="306901.Q2GS31"/>
    <dbReference type="GeneID" id="4394665"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09223"/>
    <dbReference type="eggNOG" id="ENOG502QVFG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007968_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GS31"/>
    <dbReference type="OMA" id="WIRTILC"/>
    <dbReference type="OrthoDB" id="2128042at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031606">
        <property type="entry name" value="Kch1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424:SF1">
        <property type="entry name" value="LOW AFFINITY K(+) TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16944">
        <property type="entry name" value="KCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="717"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ85209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="737" mass="81536" checksum="273010B3DBD11F7B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GS42</accession>
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        <recommendedName>
            <fullName evidence="4">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">CHGG_09212</name>
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    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227139.1">
        <property type="nucleotide sequence ID" value="XM_001227138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GS42"/>
    <dbReference type="STRING" id="306901.Q2GS42"/>
    <dbReference type="GeneID" id="4394666"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09212"/>
    <dbReference type="eggNOG" id="KOG1940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012592_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GS42"/>
    <dbReference type="OMA" id="FRRQLMH"/>
    <dbReference type="OrthoDB" id="10253329at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="628" mass="69177" checksum="115E0AE4BE99B89C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GS60</accession>
    <name>Q2GS60_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_09194</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
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</entry>
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                <person name="Untereiner W.A."/>
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            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="213" mass="22943" checksum="2CBE073459FE5D5D" modified="2006-03-21" version="1">MHLLQSLARVAGFMGLARRQFDPDSTPFEDAETGLTFASYTSDRGIIFRVAIPDPVPEDKVFDTVLQIVSPADVGWAGFAWGGHMTYNPLAIGWADGAGSVVLSSRIAYGYFSPPENPDAQYTVLETGTHANETHWQVTAKCTGCSRWGDDDMGYTEIDPSAQTTVAFAYSDTPVDTPADPASNFGIHDSLGHPIYDLATGKNADFDEKVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTP9</accession>
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    </protein>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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    <dbReference type="GeneID" id="4395488"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08655"/>
    <dbReference type="eggNOG" id="ENOG502SS7G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048145_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTP9"/>
    <dbReference type="OMA" id="AHWYEAQ"/>
    <dbReference type="OrthoDB" id="4121058at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="480" mass="51544" checksum="D913B9F5AA13447D" modified="2006-03-21" version="1">MSLIPPSSRDGWSYSGDFHVEASGNNRHRRATIPELKAVFDGTDGQKDRPAHWYEAQLIHYGLPPSKTKGTAKMRLFDAVGKGNLTVPAHILKVETELKKEWNKREREARQTAKLLGPTATAAKKPTKRKADDSQGGASSGTNVNINLSLSIGPQGSVQVAPTGPVAKKAKTTPATKKPAPVTKKPAPTTKKPAPATKKPAPATKKPAPATKKPAPATKKAASTAKNGALATLNPTQTAPPKKQTARRGTARAGASMSASSRITPAASPASADKPVARQTARRSRPFDRASQGRTTAASPQASRFDATPSHWDSIGSPPPPYPGPPSYFDDNDGDDGYHPSGLPPLGLLNGRYQLRCTAPHAHADDEYDSGIIFTLDGDALWGSFEIGPLSGILRLDERPWSSSHQPLYFEWRGEDSQGGAHSETDDGSYIKFLGNGEVVGQIGFYNTMLEFDGYRVSGSDTRSEVSAFSMRREWDERFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU34</accession>
    <name>Q2GU34_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226447.1">
        <property type="nucleotide sequence ID" value="XM_001226446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GU34"/>
    <dbReference type="GeneID" id="4395626"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08520"/>
    <dbReference type="HOGENOM" id="CLU_1245217_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GU34"/>
    <dbReference type="OrthoDB" id="4570891at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="222" mass="25728" checksum="FA8A5C3F07FE3FDF" modified="2006-03-21" version="1">MSRYKENNRQDNTRQRERRRLWDRFIRVANPFKKGMLEASVDLEKDFSQIFLCHAKMYVFADYYGISRLMDLSREKLGHLLIALTTDMEFHGQRLADFVALVRYCYDKPSPEALQSFVMMYSAYHAKLLWKDAQFQELLKDDGEVAFAFIKEVMPAYLNAKDGVSSEESSSEKSSSEKSPSEESSSEESSSEESSPRQEIPKPRLPPIGRRLTFRGGLPPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU42</accession>
    <name>Q2GU42_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">6-phosphogluconate dehydrogenase NADP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226439.1">
        <property type="nucleotide sequence ID" value="XM_001226438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GU42"/>
    <dbReference type="STRING" id="306901.Q2GU42"/>
    <dbReference type="GeneID" id="4395118"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08512"/>
    <dbReference type="eggNOG" id="KOG0409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035117_2_2_1"/>
    <dbReference type="InParanoid" id="Q2GU42"/>
    <dbReference type="OMA" id="TPVAIRW"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF2">
        <property type="entry name" value="CYTOKINE-LIKE NUCLEAR FACTOR N-PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="1">
        <location>
            <begin position="4"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="303" mass="30962" checksum="6F96459FCCA8FAF1" modified="2006-03-21" version="1">MATITSIGIGNMGAALASALLKSANPPQLTIWNRTADRPQVKALITSGATFEPSLTAAIARSTTILICLLDYAAITTALAPLSATTSTTDNNDTPGPLTGKTIINLTNGTPTQARAMAATLTGLGAAAYFDGGIMVTPQLVGTPASFVILSSGGGGHGTSQAEFEDGGVAALLQPVGKVEYVAGDDAGAASLYDVAALTAMYGMFMGAFTGIALLGKQKGQDDGGEKGVVQEGGGMGRRACGISCRRVRRRAWMGRGCGLSRSSWIARWRRGLEPVVSRLSRSICLSEDGVILGSRDGAGVHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUH7</accession>
    <name>Q2GUH7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_08377</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226304.1">
        <property type="nucleotide sequence ID" value="XM_001226303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUH7"/>
    <dbReference type="FunCoup" id="Q2GUH7">
        <property type="interactions" value="929"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GUH7"/>
    <dbReference type="GeneID" id="4394787"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08377"/>
    <dbReference type="eggNOG" id="KOG3285">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072097_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUH7"/>
    <dbReference type="OMA" id="WQFDVEI"/>
    <dbReference type="OrthoDB" id="1806at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033597">
        <property type="term" value="C:mitotic checkpoint complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990498">
        <property type="term" value="C:mitotic spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905318">
        <property type="term" value="P:meiosis I spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.900.10:FF:000002">
        <property type="entry name" value="Mitotic spindle assembly checkpoint protein MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF11">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="8">
        <location>
            <begin position="19"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ84363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="239" mass="26556" checksum="94CB94E00A019C46" modified="2006-03-21" version="1">MASAAPEKDKSKVHKLSLKGSAKLVAEFFQYSIHTILFQRGVYPAEDFTAVKKYGLNMLVSSDDQVRAYIKKIMSQLDKWMVGGKIQKLVIVITDKDTGEHVERWQFDVQIFAKSKTSKSSKSKPSTKPNNQENENTPTPPTDDPPAAAAPKEKTEAEIQAEIAAIFRQITASVTFLPQLQGGDCTFNVLVYADASSEVPVEWGDSDAKEIENAERVQLRGFSTQSHRVDTLVSYRLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX81</accession>
    <name>Q2GX81_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_07423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225079.1">
        <property type="nucleotide sequence ID" value="XM_001225078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX81"/>
    <dbReference type="GeneID" id="4394042"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07423"/>
    <dbReference type="HOGENOM" id="CLU_2222968_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GX81"/>
    <dbReference type="OrthoDB" id="10433602at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ86170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="106" mass="11273" checksum="7C9354042F694005" modified="2006-03-21" version="1">MANLHTHTIPQTIHTLNLAVPDDKTAISTPKIDYHPVTKVTSEDAFDIVVHSGKMVVKAKTVEESIAAAKLASAITEQQRCARAAYMRSLRVPVITAGLAVAGVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXD1</accession>
    <name>Q2GXD1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_07373</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225029.1">
        <property type="nucleotide sequence ID" value="XM_001225028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXD1"/>
    <dbReference type="STRING" id="306901.Q2GXD1"/>
    <dbReference type="GeneID" id="4393627"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07373"/>
    <dbReference type="eggNOG" id="ENOG502SZ7B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063084_5_1_1"/>
    <dbReference type="InParanoid" id="Q2GXD1"/>
    <dbReference type="OMA" id="CALPCID"/>
    <dbReference type="OrthoDB" id="3767534at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209102" description="CFEM domain-containing protein" evidence="12">
        <location>
            <begin position="19"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="13">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="89"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ86120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="218" mass="21257" checksum="298AF36932085500" modified="2006-03-21" version="1">MKYSTVALALAAASSASAQDISIFPECSLPCIIDGIGTTSCEATDFACVCKNMEAIKQAATPCVVDKCGLDTALNKVLPATEKFCADVGNGDSDDGGDDSSSEAPPPPATTTLATVTTSAPSEPEPTETETPGGGDGGDDDGEGDGDDDDDDEPTETASSGGSMVTPGPTGSAIPSPTGGDDDDTPPPATSSIQTAGAAVVGAVGSFGMMLLGAVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXT1</accession>
    <name>Q2GXT1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_07223</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224879.1">
        <property type="nucleotide sequence ID" value="XM_001224878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXT1"/>
    <dbReference type="FunCoup" id="Q2GXT1">
        <property type="interactions" value="782"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GXT1"/>
    <dbReference type="GeneID" id="4393223"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07223"/>
    <dbReference type="eggNOG" id="KOG2732">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021763_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GXT1"/>
    <dbReference type="OMA" id="HCILIGT"/>
    <dbReference type="OrthoDB" id="3763at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.430:FF:000002">
        <property type="entry name" value="DNA polymerase delta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.50:FF:000006">
        <property type="entry name" value="DNA polymerase delta subunit 2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040663">
        <property type="entry name" value="DNA_pol_D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18018">
        <property type="entry name" value="DNA_pol_D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA polymerase delta subunit OB-fold" evidence="12">
        <location>
            <begin position="48"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="11">
        <location>
            <begin position="227"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="194"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ85970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="497" mass="54770" checksum="F93CB49F4A7580E0" modified="2006-03-21" version="1">MVTLDEIAGTALLQKPSNTPTASLERPESNYKSLGNFSLPNDRQYKQQFADIYFLRLTKIRPAVEEVATAAWQDTVLGGETATKVDRVLDVRQGQLCWVIGTVYMEMPLKPSVLEDVSKDRWISAPTMADHYYDGAGAESIMLEDDSGRVPLVGSVLKDYFLVTGCIIAVMGTENSDGQFEVIDLKFADLPSQPGRWSLSKGPKKPKVKDEDVEMADSSRPQPPKKIAIVSGLEFSGTDTSYAMELNLLLEFLLGEALDPAAQVELSQISRLIIAGNSIAKPSEHDPATDKRVLKKYGYDSSSYNPLPSQLLDTFLSSLLPTLPITLLPGAQDPANVSYPQQPIHPAMFPNARTYTAAPGASEQPGWFDPVTNPWEGEVEGWRVLGTGGQNLDDICKYVDSEDRLGMMEAMCRWRCSAPTAPDTLWSYPFQDDEPFVMKDCPHLYFVGCQPEFGTKIIESPQGQMVRLVLIPSFAATKEIVLIDTETLDVSKVKITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GY66</accession>
    <name>Q2GY66_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224744.1">
        <property type="nucleotide sequence ID" value="XM_001224743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GY66"/>
    <dbReference type="GeneID" id="4393829"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07088"/>
    <dbReference type="eggNOG" id="ENOG502T75R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164903_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GY66"/>
    <dbReference type="OMA" id="PYERIPT"/>
    <dbReference type="OrthoDB" id="4829316at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="99" mass="10937" checksum="D443592C0CB8237F" modified="2006-03-21" version="1">MPARTVTRPVLQTLARQLQQQGIQQQRPQPFSIMHNLRAIARSFEPHPFQRLPVASSPAPADWARLVRRAGGQAVVFFPAGLLMLGWPYAAAAVLDGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYF0</accession>
    <name>Q2GYF0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_07004</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224660.1">
        <property type="nucleotide sequence ID" value="XM_001224659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYF0"/>
    <dbReference type="FunCoup" id="Q2GYF0">
        <property type="interactions" value="920"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GYF0"/>
    <dbReference type="GeneID" id="4394258"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07004"/>
    <dbReference type="eggNOG" id="KOG1465">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_4_3_1"/>
    <dbReference type="InParanoid" id="Q2GYF0"/>
    <dbReference type="OMA" id="SHSCAVA"/>
    <dbReference type="OrthoDB" id="269919at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="107"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ85751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="426" mass="45998" checksum="83EC4BB44A44ED36" modified="2006-03-21" version="1">MAPSQAAHVPTLDNLIKSFNNQTLEASIESLIFLLKRRQVKGDECAKATAHILRQVVAKSKWNDVDQLLSRIQSYGSRLARAAPLEPVIGNVVRRVLGLIRDEATEDRNADDLASEAASDIQSLTPSTNPNAHPPQRPAPVPIRPSPSVISTGLQVSKSMFNLLSVANPGDSPITGASTPMSQAQPASAHALRSEVMDGIEEILDEINQADDQIAGFSEIQIHPGDYVLAYQPSRTVEKFLVKAASKRRFTVLIASHAFSYGTSEAPYATLRKKLNAAGVNTINLASNGLMAYIPRVNKVIFSAKAVYQNGGLLVDSGSCIAAQAAYEYLKPVIVLCPVYKFCPEDPSDEVSRGELGNPSSYVSYANGPAVDALDVENTVTDYIPPELIDVYLTNLGPQTRHHLASILADHYKTEDIGFSLQLGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYR3</accession>
    <name>Q2GYR3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_06891</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224547.1">
        <property type="nucleotide sequence ID" value="XM_001224546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYR3"/>
    <dbReference type="GeneID" id="4393215"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06891"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="InParanoid" id="Q2GYR3"/>
    <dbReference type="OMA" id="MYLTGIF"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF29">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="36"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ85638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="497" mass="55367" checksum="ED6ED48FB8F552CC" modified="2006-03-21" version="1">MGGGREDEDDRIHRMAMEDPVAWYKKPNLRRMYLLLFPCVIGIEMTSGFDSQIINSAQLLPAWKDFFGHPTGAYNGILASALPLGSVIGLPFIPFVNDTFGRRWCIMLGSWVMIIGAILQGLAINGPMYIMARGIIGFGLPFAIVAGASLIGELGYPKERPILTSLFNACYFIGAIVAAGCTYGTQTIHNDWSWRIPSFLQMAPALLQVTFVFFLPESPRFLMSKDKYEEAEAVLIKYHAEGDASSEFVKAEILEIKTTLQIEMENSKRSWMDLVRTAGMRRRLLIGSLLGLFTQLSGNVVISYFLGDVLKLIGYTDPAFQTQYNLGNQCWSLVCGVSAALVVMRFRRRTMYMTGILAILAVYVAWTTCTAVFIVNHSQVAAKLCLFFIYAYSPAYNLCFNALTYSDGDGDGGGGGDGRLAAGTGAIGWKFLLVYCCWIVVEAVLIWFLWPETSGRSLEELAFLFEQDEYALRHEKLGIEEHEEKTATHIVETQERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZ47</accession>
    <name>Q2GZ47_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_05199</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224413.1">
        <property type="nucleotide sequence ID" value="XM_001224412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZ47"/>
    <dbReference type="GeneID" id="4391930"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05199"/>
    <dbReference type="eggNOG" id="ENOG502RM5X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_403845_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZ47"/>
    <dbReference type="OrthoDB" id="4590898at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="301"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="657"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="246"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="670"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ88580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="681" mass="73342" checksum="273745F672B56534" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZ60</accession>
    <name>Q2GZ60_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224400.1">
        <property type="nucleotide sequence ID" value="XM_001224399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZ60"/>
    <dbReference type="GeneID" id="4392278"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05186"/>
    <dbReference type="eggNOG" id="ENOG502RISZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_721602_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZ60"/>
    <dbReference type="OMA" id="VVPDTWT"/>
    <dbReference type="OrthoDB" id="5005275at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="354" mass="38364" checksum="A22BBB21E049221F" modified="2006-03-21" version="1">MLNAEAKIETLEEDWEGKWFSIVARLFPNKLTFQGVGFSGWETDESQSAQVALALPRDDGLTPVIPRQLGGPDQTAPWPSTSAHVSFARPVDLDTFHIKQGVWPRPLVKTSVFVKLGSYLQSENDRPPREGIHICHVLVLFPVDQQPWKSLAGWMRTAANPFPKGSWIACSGRLLGVLDRDLIQGPRKADPTVRILVILADSWELIRQNSPSTNNTPTPKSSDPVGNLPTTPRSAGPGAVASRNPFSSLGRAQNPTSSPQNPSSSPVAPETAEREAIEPPSSPGAQLDSITADPDQMPTDGDDSNDGSDTEELLDAQLVSSSSTPTKKRKEPSSPEPARSKRSTAGRKKARLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZG5</accession>
    <name>Q2GZG5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_05059</name>
        <name evidence="2" type="ORF">CHGG_05081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2005-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Giovannoni S.J."/>
                <person name="Cho J.-C."/>
                <person name="Ferriera S."/>
                <person name="Johnson J."/>
                <person name="Kravitz S."/>
                <person name="Halpern A."/>
                <person name="Remington K."/>
                <person name="Beeson K."/>
                <person name="Tran B."/>
                <person name="Rogers Y.-H."/>
                <person name="Friedman R."/>
                <person name="Venter J.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 148.51</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2006-02" db="EMBL/GenBank/DDBJ databases">
            <title>Annotation of the Chaetomium globosum CBS 148.51 Genome.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Birren B."/>
                <person name="Lander E."/>
                <person name="Galagan J."/>
                <person name="Devon K."/>
                <person name="Nusbaum C."/>
                <person name="Ma L.-J."/>
                <person name="Jaffe D."/>
                <person name="Butler J."/>
                <person name="Alvarez P."/>
                <person name="Gnerre S."/>
                <person name="Grabherr M."/>
                <person name="Kleber M."/>
                <person name="Mauceli E."/>
                <person name="Brockman W."/>
                <person name="Rounsley S."/>
                <person name="Young S."/>
                <person name="LaButti K."/>
                <person name="Pushparaj V."/>
                <person name="DeCaprio D."/>
                <person name="Crawford M."/>
                <person name="Koehrsen M."/>
                <person name="Engels R."/>
                <person name="Montgomery P."/>
                <person name="Pearson M."/>
                <person name="Howarth C."/>
                <person name="Kodira C."/>
                <person name="Yandava C."/>
                <person name="Zeng Q."/>
                <person name="Alvarado L."/>
                <person name="Oleary S."/>
                <person name="Untereiner W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 148.51</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224273.1">
        <property type="nucleotide sequence ID" value="XM_001224272.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224295.1">
        <property type="nucleotide sequence ID" value="XM_001224294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZG5"/>
    <dbReference type="STRING" id="306901.Q2GZG5"/>
    <dbReference type="GeneID" id="4392305"/>
    <dbReference type="GeneID" id="4392640"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05059"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05081"/>
    <dbReference type="eggNOG" id="ENOG502SCDQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001613_3_3_1"/>
    <dbReference type="InParanoid" id="Q2GZG5"/>
    <dbReference type="OMA" id="CTTYKGP"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ88440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="145" mass="15901" checksum="727727CEF79A3F3B" modified="2006-03-21" version="1">MVAFDDYDGPAFTMSNGEPLRSGEKLVVPILRVRQEFMVGANSCSREQFPLLVSYAITVHKSQGITLDKIVCDISAPEFASGLSYVAVSRVKTLGGLMFERPFDRSRVYRETPSRAMGLKLSDHATRQLQALDAVAGEAPSEESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZQ1</accession>
    <name>Q2GZQ1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_04995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224209.1">
        <property type="nucleotide sequence ID" value="XM_001224208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZQ1"/>
    <dbReference type="GeneID" id="4392020"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04995"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_281992_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZQ1"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF1">
        <property type="entry name" value="OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="577"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="486"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="650"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="714"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="790"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ88376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1109" mass="120247" checksum="D96C49BCD7129382" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZY1</accession>
    <name>Q2GZY1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 30 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_04915</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224129.1">
        <property type="nucleotide sequence ID" value="XM_001224128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZY1"/>
    <dbReference type="STRING" id="306901.Q2GZY1"/>
    <dbReference type="GeneID" id="4391544"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04915"/>
    <dbReference type="eggNOG" id="KOG4813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_836786_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZY1"/>
    <dbReference type="OrthoDB" id="20381at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.60:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.60">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023194">
        <property type="entry name" value="eIF3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="246"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ88296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="332" mass="35452" checksum="67DA6E3E6622BB92" modified="2006-03-21" version="1">MALGDWLPLVTLSDLPSTAKLQQALGCRNGTAPGSERRGVGRKRRSPAQLRTPRLSAPGVANSTTRKLRIAMFLESWDAAEDSEVEREEGKEGRRSQGPRRKQKQLPNKKSKSQRIAERQVRTCSGSGQRLDDEDSEEETEAQARERLPLASAAGRKATTAGSAVPIDASDPSKTVDLSALPLFKPGTKLQFEQLRNVLGPILSGSSKKAHYTLFLQEFTKQLAKELPSDQIKKIASTLTALSNEKMKEEKAADKGGKKSKAAKTKTSLAGVSRGGGMADTAAYDDDDAGFGEGEQVIASPVVPRSAATITPTGKPCAGPARDLAYSLSSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H074</accession>
    <name>Q2H074_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224036.1">
        <property type="nucleotide sequence ID" value="XM_001224035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H074"/>
    <dbReference type="GeneID" id="4392670"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04822"/>
    <dbReference type="HOGENOM" id="CLU_2849502_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H074"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="65" mass="7444" checksum="16398C0A591372E0" modified="2006-03-21" version="1">MSSHQSTTPQTPPQSQQPSSLSSRLSLLKDKLRPKRKTTRRGNSSQQQQQKAKDDVLRNQIRMNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0G9</accession>
    <name>Q2H0G9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_04727</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223941.1">
        <property type="nucleotide sequence ID" value="XM_001223940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0G9"/>
    <dbReference type="FunCoup" id="Q2H0G9">
        <property type="interactions" value="1375"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H0G9"/>
    <dbReference type="GeneID" id="4392889"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04727"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000513_2_1_1"/>
    <dbReference type="InParanoid" id="Q2H0G9"/>
    <dbReference type="OMA" id="WEHLEYI"/>
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    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019240">
        <property type="term" value="P:citrulline biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01423">
        <property type="entry name" value="MGS_CPS_I_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000002">
        <property type="entry name" value="Aspartate carbamoyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000005">
        <property type="entry name" value="CAD protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000036">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000009">
        <property type="entry name" value="Carbamoyl-phosphate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002032">
        <property type="entry name" value="PRK00856.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF5">
        <property type="entry name" value="CAD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00101">
        <property type="entry name" value="ATCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
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    </dbReference>
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        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
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    </dbReference>
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        <property type="entry name" value="PreATP-grasp domain"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
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    </dbReference>
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        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="38"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="12">
        <location>
            <begin position="295"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ88108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1163" mass="128351" checksum="E6F078014BBB2D31" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0K0</accession>
    <name>Q2H0K0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mob1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223910.1">
        <property type="nucleotide sequence ID" value="XM_001223909.1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04696"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027210_1_0_1"/>
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    <dbReference type="OMA" id="YCCAIDY"/>
    <dbReference type="OrthoDB" id="10262609at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="463"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="562"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="573"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="65734" checksum="9EC7060525AFDC8B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H189</accession>
    <name>Q2H189_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_04457</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="2">The Mn(2+) ion enhances activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223671.1">
        <property type="nucleotide sequence ID" value="XM_001223670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H189"/>
    <dbReference type="STRING" id="306901.Q2H189"/>
    <dbReference type="GeneID" id="4391704"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04457"/>
    <dbReference type="eggNOG" id="ENOG502QQEM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023257_6_0_1"/>
    <dbReference type="InParanoid" id="Q2H189"/>
    <dbReference type="OMA" id="PILMASC"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014:SF63">
        <property type="entry name" value="METALLOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PEPTIDASE M20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005962-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ87838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="43276" checksum="E8E35D6F0216C081" modified="2006-03-21" version="1">MTANLPEIALLRDVVEGHRPNLTQYADFYRDVHRHPEVAAMEKETAEKVAAHLTRLGFKVHSGIGGHGVVGVFQNGVGKTILTRAELDALPILEQTSVPYRSERRMVDRYGNERPTMHACGHDMNMAALLAAADLLNSAAHRWKGTLLVVFQPEEEELSGAKAMLDDGFYDLVPVPDIMLSQHVVPARAGTVAIRSGPILAADTMRIRVIDGPCEGSINPQFCVDPVLLGMRIVSGLQDAVTKEVGQDEDATVACWGFHAGVPGNDYVAYANILLDIKTVKSDIPQRVLGLITKLFLDQCRAAGVPRDPEINHSVRAPLTSNHESIVKPIDRVFRDYFTSKMTEMAFVRSTEDFSVFGATHNIRGGRNDWRPKSLYTHHTQGSGSTRREIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H194</accession>
    <name>Q2H194_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Dihydroxyacetone kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_04452</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223666.1">
        <property type="nucleotide sequence ID" value="XM_001223665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H194"/>
    <dbReference type="STRING" id="306901.Q2H194"/>
    <dbReference type="GeneID" id="4391647"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04452"/>
    <dbReference type="eggNOG" id="KOG2426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017054_6_0_1"/>
    <dbReference type="InParanoid" id="Q2H194"/>
    <dbReference type="OMA" id="TNTHWES"/>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="UniPathway" id="UPA00617">
        <property type="reaction ID" value="UER00669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019588">
        <property type="term" value="P:anaerobic glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase, DhaK subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF4">
        <property type="entry name" value="TRIOKINASE_FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="15">
        <location>
            <begin position="9"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="14">
        <location>
            <begin position="388"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="351"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-hemiaminal-histidine intermediate" evidence="11">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="54"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAQ87833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="607" mass="63896" checksum="DD51B76F1486A3C7" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1B2</accession>
    <name>Q2H1B2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_04434</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. COT1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223648.1">
        <property type="nucleotide sequence ID" value="XM_001223647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1B2"/>
    <dbReference type="FunCoup" id="Q2H1B2">
        <property type="interactions" value="467"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H1B2"/>
    <dbReference type="GeneID" id="4392241"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04434"/>
    <dbReference type="eggNOG" id="KOG0605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_67_5_1"/>
    <dbReference type="InParanoid" id="Q2H1B2"/>
    <dbReference type="OMA" id="HDNAYYQ"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902554">
        <property type="term" value="C:serine/threonine protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007118">
        <property type="term" value="P:budding cell apical bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071472">
        <property type="term" value="P:cellular response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097248">
        <property type="term" value="P:maintenance of protein location in cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000247">
        <property type="term" value="P:positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045921">
        <property type="term" value="P:positive regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062200">
        <property type="term" value="P:RAM/MOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032995">
        <property type="term" value="P:regulation of fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050708">
        <property type="term" value="P:regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000920">
        <property type="term" value="P:septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000086">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000229">
        <property type="entry name" value="Serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000192">
        <property type="entry name" value="Serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="98"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="15">
        <location>
            <begin position="403"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAQ87815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="484" mass="55796" checksum="D20B957545EACD3E" modified="2006-03-21" version="1">MPTQTPQLDYFAPAPERNPDKYGPNANNNQKKCSQLASDFFKDSVKRARERNQRQSEMEQKLAETTDPRRRESVWATGGRREGSYLRFLRTKDKPENYNTIKIIGKGAFGEVKLVQKKADGKVYAMKSLIKTEMFKKDQLAHVRAERDILAESDSPWVVKLFTTFQDTNFLYMLMEFLPGGDLMTMLIKYEIFSEDITRFYIAEIVLAIDAVHKLGFIHRDIKPDNILLDRGGHVKLTDFGLSTGFHKLHDNNYYQQLLQGKSNKPRDNRNSIAIDQINLTVSNRSQINDWRRSRRLMAYSTVGTPDYIAPEIFTGHGYSFDCDWWSLGTIMFECLVGWPPFCAEDSHDTYRKIVNWRQSLYFPDDIQLGVEAENLIRSLICNSENRLGRGGAHEIKSHSFFRGVEFDSLRRIRAPFEPRLTSNIDTTYFPTDEIDQTDNATMLKAAQARSAASGVPAGQQEESPEMSLPFIGYTFKRFDNNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H234</accession>
    <name>Q2H234_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sphingoid long-chain base transporter RSB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_04162</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223376.1">
        <property type="nucleotide sequence ID" value="XM_001223375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H234"/>
    <dbReference type="GeneID" id="4391751"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04162"/>
    <dbReference type="eggNOG" id="ENOG502QU4U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_6_1_1"/>
    <dbReference type="InParanoid" id="Q2H234"/>
    <dbReference type="OMA" id="LAPTFIC"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="315"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ87543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="40033" checksum="A00694CD4E34095A" modified="2006-03-21" version="1">MVELDPSMFPPGWDQDAIDDAIANYYYSCTHITANCTVEATTLGYYPNRGINIFLVIGFAVATVIALVLGILKKTWSYTSFIAARCALELPGYGARIPLTDNPWNKHAFETQIVAIILAPTLVCISIYLTLKHVCLALNPTLSRVRPHLYPFVFVPLDVSCLLVQAIGGALAASAATSNFKMVQHGNRCIIAGIVLQVVVLSFFGTSAGDYYLRVRKWINSPEADPEAVALWRDKKFRMFVYAVTGAYSGILIRCIYRIAEMAGGWGNHIMQDEPSFIVLEGFMVLIPCLLLAIFAPGYLFPQMAARMSAPGRVGLKRKDGEQTDDAEKKAQPGALGGQQPTTSGDESAVGEQVKEAAVPAVEEAKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H246</accession>
    <name>Q2H246_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223364.1">
        <property type="nucleotide sequence ID" value="XM_001223363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H246"/>
    <dbReference type="GeneID" id="4393099"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04150"/>
    <dbReference type="eggNOG" id="KOG2029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_900158_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H246"/>
    <dbReference type="OMA" id="TINSAPW"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="35"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="309" mass="35354" checksum="827125A237B6BCA9" modified="2006-03-21" version="1">MELRFYTGHNISIAGTCEWLFQHKEWERWQFGSDNLMWIKGKAGSGKSTLLRYAEREVKRMGAKSNALTLSFYFHGRGEELQRTPLGMYRSLLCQILKHEPASLSQLVETFAYKQNEKNGSGAAWKWDPDHLGNLLDWAIDGILASRPIWLFIDGLDECGPEGAEEILQRLNRLRRPGLFICVSCRNDSLRHSDGGFRIKVEEHNKHDIVRYAQSQLAHLESKTAFSIPDFIATYSDGCFSSAYLAVARLRSVEIGMEAREIEDTVKQTINSAPWDLNDLPTLLARNFWGDSTRYGHQFNGVNVSIRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2W2</accession>
    <name>Q2H2W2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_03884</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223098.1">
        <property type="nucleotide sequence ID" value="XM_001223097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2W2"/>
    <dbReference type="FunCoup" id="Q2H2W2">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H2W2"/>
    <dbReference type="GeneID" id="4391610"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03884"/>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021868_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2W2"/>
    <dbReference type="OMA" id="IFVYFYD"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209228" description="Thioredoxin domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="178"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ87265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="676" mass="76396" checksum="CDE0A7833846822E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3K6</accession>
    <name>Q2H3K6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_06759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222854.1">
        <property type="nucleotide sequence ID" value="XM_001222853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3K6"/>
    <dbReference type="STRING" id="306901.Q2H3K6"/>
    <dbReference type="GeneID" id="4390093"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06759"/>
    <dbReference type="eggNOG" id="ENOG502T6J4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_523725_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3K6"/>
    <dbReference type="OrthoDB" id="5139479at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ90140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="520" mass="56431" checksum="93221FB4DCF0B56C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3Q5</accession>
    <name>Q2H3Q5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_06710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222805.1">
        <property type="nucleotide sequence ID" value="XM_001222804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3Q5"/>
    <dbReference type="STRING" id="306901.Q2H3Q5"/>
    <dbReference type="GeneID" id="4390817"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06710"/>
    <dbReference type="eggNOG" id="ENOG502SA7U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089381_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H3Q5"/>
    <dbReference type="OMA" id="YARMNEY"/>
    <dbReference type="OrthoDB" id="4822at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47251">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47251:SF1">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ90091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="173" mass="18317" checksum="860E25A7D2D9E7AC" modified="2006-03-21" version="1">MPPRHQTLPPAQTSSAREALQSFYCQLCQKGYSRMNDYEAHLSSYDHSHKQRLKDMKAMVRDPAATARARRQEQKAEGVISIKLGEAAAGVSGGGTSAAGGGFKKGGFKKTGFKSAFGPVVGGVALPKEDAAGPGKKEGEPKMGLAAAAKSGLVESDTEDEGYEVYDPRRPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3W6</accession>
    <name>Q2H3W6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">37S ribosomal protein S35, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_06649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222744.1">
        <property type="nucleotide sequence ID" value="XM_001222743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3W6"/>
    <dbReference type="STRING" id="306901.Q2H3W6"/>
    <dbReference type="GeneID" id="4390610"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06649"/>
    <dbReference type="eggNOG" id="ENOG502QVMS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049223_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H3W6"/>
    <dbReference type="OMA" id="KGTGWRY"/>
    <dbReference type="OrthoDB" id="10052321at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021036">
        <property type="entry name" value="Ribosomal_mS45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S35, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12298">
        <property type="entry name" value="Bot1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ90030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38930" checksum="6CFA63D8A4E0C090" modified="2006-03-21" version="1">MPPRIRGSSCQPQLLLNYLEPASSSILPSAAIIPLHRPTASLPKCNRAFSTTPAPQITKLRRAFKEWCEENEEMFRQHPRDRHMNYITTGSRPFPNNPNFRSEPVLSSEARKMIWEAIMVKGMPLKAVSAEFHVDMRRVAAVVRMMEIEKKYEREVTNTCRQGQPLAHAYARAIEKMLPRQDLRDGEDKFEPINDIHVHSHTMQQLFVPTSESREFTRADAAKAFGEHILPPDAKMRIPELVQMEKNIAEGMDEREARGHFIKEAAESEQAFAEKQRARAVAAEGRKTRVNTGRFEFRFEKINAEDVGPTGRARKAVGWRYGAPHMDRRRGEVKIPTHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3Z4</accession>
    <name>Q2H3Z4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222716.1">
        <property type="nucleotide sequence ID" value="XM_001222715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3Z4"/>
    <dbReference type="GeneID" id="4390577"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06621"/>
    <dbReference type="HOGENOM" id="CLU_1214614_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3Z4"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="228" mass="25277" checksum="7A1EFC2B3A0401FB" modified="2006-03-21" version="1">MARGNRRIPGTRRLTRAAAAQRQRPEPVARRPGRPIGMDTARLGHLVTNRSPIIELVTVRPFEVGELGGDLLPPSRSGLCQPTLVLGEAGGLRDKEDLSRRCGGLVPRALWNVQLDRRPTTDDRRERMNDTGKGGTGSYGIESTLLCMVTFAAPIATWRDREPWLPFLRPTRWPRAGALEARLGFGVQSPRRDGNRETQSEAGDSAKILDRPLPVLREVPFTQHALVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H423</accession>
    <name>Q2H423_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">DNA polymerase</fullName>
            <ecNumber evidence="22">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">CHGG_06592</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="21">Forms DNA polymerase zeta with REV7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the DNA polymerase type-B family.</text>
    </comment>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd05778">
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        <property type="entry name" value="POLBc_zeta"/>
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        <property type="entry name" value="DNA polymerase zeta"/>
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        <property type="entry name" value="DNA polymerase zeta catalytic subunit"/>
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    <dbReference type="Gene3D" id="1.10.132.60">
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        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
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    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
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    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
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    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
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    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
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    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
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        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
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    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
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        <property type="entry name" value="DNA_pol_B_thumb"/>
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        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
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        <property type="entry name" value="DPOD/Z_N"/>
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        <property type="entry name" value="PolZ_Rev3"/>
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        <property type="entry name" value="REV3_N"/>
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        <property type="entry name" value="RNaseH-like_sf"/>
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        <property type="entry name" value="RNaseH_sf"/>
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    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
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        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
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        <property type="entry name" value="DNA_pol_B"/>
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        <property type="entry name" value="DNA_pol_B_exo1"/>
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        <property type="entry name" value="POL3_N"/>
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        <property type="entry name" value="REV3_N"/>
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        <property type="entry name" value="DNAPOLB"/>
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        <property type="entry name" value="DNA_POLYMERASE_B"/>
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    <keyword evidence="8 22" id="KW-0235">DNA replication</keyword>
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    <keyword evidence="13 22" id="KW-0239">DNA-directed DNA polymerase</keyword>
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    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 22" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase zeta catalytic subunit N-terminal" evidence="27">
        <location>
            <begin position="4"/>
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        </location>
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    <feature type="domain" description="DNA polymerase delta/zeta catalytic subunit N-terminal" evidence="26">
        <location>
            <begin position="61"/>
            <end position="142"/>
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    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="25">
        <location>
            <begin position="861"/>
            <end position="1052"/>
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    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="24">
        <location>
            <begin position="1119"/>
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    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="413"/>
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    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="23">
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    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="820"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="422"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="23">
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            <begin position="669"/>
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    <evidence type="ECO:0000256" key="1">
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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            <dbReference type="ARBA" id="ARBA00004173"/>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF24055"/>
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            <dbReference type="Pfam" id="PF24065"/>
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        <source>
            <dbReference type="EMBL" id="EAQ89973.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
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    </evidence>
    <sequence length="1755" mass="197530" checksum="69AF90A5526A2C43" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H427</accession>
    <name>ATG3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Autophagy-related protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Autophagy-related E2-like conjugation enzyme ATG3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ATG3</name>
        <name type="ORF">CHGG_06588</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8. The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8 from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8. The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Interacts with ATG8 through an intermediate thioester bond through the C-terminal Gly of ATG8. Also interacts with the 40 amino acid C-terminal region of the E1-like ATG7 enzyme. Also interacts with the ATG12-ATG5 conjugate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The N-terminal region is involved in phosphatidylethanolamine-binding and is required for ATG8-PE conjugation.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The flexible region (FR) is required for ATG7-binding.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The handle region (HR) contains the ATG8 interaction motif (AIM) and mediates binding to ATG8. It is crucial for the cytoplasm-to-vacuole targeting pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001222682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H427"/>
    <dbReference type="SMR" id="Q2H427"/>
    <dbReference type="FunCoup" id="Q2H427">
        <property type="interactions" value="964"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H427"/>
    <dbReference type="GeneID" id="4390343"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06588"/>
    <dbReference type="eggNOG" id="KOG2981">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027518_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H427"/>
    <dbReference type="OMA" id="HCPTWSW"/>
    <dbReference type="OrthoDB" id="1584384at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
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    </dbReference>
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        <property type="term" value="P:autophagosome assembly"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="chain" id="PRO_0000317821" description="Autophagy-related protein 3">
        <location>
            <begin position="1"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Handle region" evidence="1">
        <location>
            <begin position="242"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="1">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="338" mass="37395" checksum="D13FBF464AC887CB" modified="2006-03-21" version="1">MNIIYSTVNSLRDRYTPASHTSTFRNTGEITPEEFVAAGDYLVFKFPSWTWSDAETPAKRVAHLPPEKQYLVTRNVPCHRRLNDDFAGDAGHEEAVVEGGKNSGDDGWLRTGGLASSQPLKARDVRTVDDAGNVADRGAIDDEDDIPDMEEEEDDEAIIQDGSHGKHSGSRTYSLYITYSPWYKTPRMYMLGYQPNGQALIPHLMMEDIVGDYKDKTVTLEDFPFFATSVKTASIHPCKHAPVMKTLLDRADAALKLRKERQKAGLEVGSNQGLEGLEAQVVKLAVSGTGTDVANDANDEWEEVQHDAADQDVAIRVDQYLFIASVTPGIEHDFTMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H458</accession>
    <name>Q2H458_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222652.1">
        <property type="nucleotide sequence ID" value="XM_001222651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H458"/>
    <dbReference type="STRING" id="306901.Q2H458"/>
    <dbReference type="GeneID" id="4390864"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06557"/>
    <dbReference type="eggNOG" id="ENOG502SFIP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_353803_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H458"/>
    <dbReference type="OMA" id="QVCDDII"/>
    <dbReference type="OrthoDB" id="5398572at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="637"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="670" mass="73593" checksum="3009D01B9F7D41CD" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4E6</accession>
    <name>Q2H4E6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_06469</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222564.1">
        <property type="nucleotide sequence ID" value="XM_001222563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4E6"/>
    <dbReference type="STRING" id="306901.Q2H4E6"/>
    <dbReference type="GeneID" id="4391189"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06469"/>
    <dbReference type="eggNOG" id="ENOG502S287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090404_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H4E6"/>
    <dbReference type="OMA" id="PIPWRFS"/>
    <dbReference type="OrthoDB" id="73901at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ89850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="155" mass="16328" checksum="FFC2294A375596FF" modified="2006-03-21" version="1">MDMGHDSSSSSSSSGHSSGHTSVFQTSMATALFSTAWTPSSTGAYAGTCIFLIVLAVIFRGLLALKSWQERRWLDAELARRYVVVQGKAPLADALARDPAAKNASLVLSENGVEENVVVVGNRGAAAAHVRPWRLSVDPLRAAVDTVVAGVGYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4M3</accession>
    <name>Q2H4M3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_06392</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222487.1">
        <property type="nucleotide sequence ID" value="XM_001222486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4M3"/>
    <dbReference type="STRING" id="306901.Q2H4M3"/>
    <dbReference type="GeneID" id="4390107"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06392"/>
    <dbReference type="eggNOG" id="ENOG502RZBR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013457_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4M3"/>
    <dbReference type="OMA" id="TEYSCTA"/>
    <dbReference type="OrthoDB" id="5431405at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209267" description="CFEM domain-containing protein" evidence="10">
        <location>
            <begin position="17"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="11">
        <location>
            <begin position="410"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="145"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="337"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="159"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="342"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ89773.1"/>
        </source>
    </evidence>
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    </evidence>
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</entry>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ89613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="306901.Q2H533"/>
    <dbReference type="GeneID" id="4390350"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06232"/>
    <dbReference type="eggNOG" id="ENOG502RS63">
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    </dbReference>
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    <dbReference type="InParanoid" id="Q2H533"/>
    <dbReference type="OrthoDB" id="3506470at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
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    </dbReference>
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            <end position="275"/>
        </location>
    </feature>
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        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="513"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="528"/>
            <end position="576"/>
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            <begin position="175"/>
            <end position="188"/>
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    </feature>
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            <end position="215"/>
        </location>
    </feature>
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        <location>
            <begin position="532"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="EAQ89613.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
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    <sequence length="645" mass="67266" checksum="87E61F400132A19C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5F8</accession>
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        <property type="project" value="InterPro"/>
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            <end position="35"/>
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    </feature>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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    </feature>
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    </feature>
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            <end position="221"/>
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    </feature>
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        <location>
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            <end position="254"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="387"/>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="EMBL" id="EAQ89488.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000001056"/>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5G0</accession>
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                <person name="Untereiner W.A."/>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <location>
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    <feature type="region of interest" description="Disordered" evidence="7">
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        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="779"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ89486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1219" mass="135908" checksum="3B02EC5531177B45" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5G6</accession>
    <name>Q2H5G6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Berberine/berberine-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_06099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222194.1">
        <property type="nucleotide sequence ID" value="XM_001222193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5G6"/>
    <dbReference type="STRING" id="306901.Q2H5G6"/>
    <dbReference type="GeneID" id="4391010"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06099"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1229804_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5G6"/>
    <dbReference type="OMA" id="QYINYAN"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25018" checksum="E9821DAE39C0B812" modified="2006-03-21" version="1">MTAVVAPRAAPLFPERLRDADSSMSPALRSHRPMISGSHSPIFGKRPRGRPSPRCEIWFTLTLKNDARILTYTSALHDQLVADLTAFIPGQDFITKCMFQHLPTIAIQNSVAAGGNVMGVKRQQHNGILFHAIAMVMTNEQETFVYHKVKMWVDSVAEFARGIEGGLLEWRYLNYANKIQDPRATYGEENIKGMQGVAAKYDPDQVFQRLCPGGFKVSAIGTPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5W5</accession>
    <name>Q2H5W5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222045.1">
        <property type="nucleotide sequence ID" value="XM_001222044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5W5"/>
    <dbReference type="GeneID" id="4390831"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05950"/>
    <dbReference type="HOGENOM" id="CLU_2222964_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5W5"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="106" mass="11257" checksum="CF3E48FEF915DF11" modified="2006-03-21" version="1">MAWPAGQGRIPDATLAMRFGAWGWENSMRGVSDSGTEACDVCLAGWPTVRGSQVPSGAGPVGSKTPRESYHGPWRHSRDGIGDIKAPGVWVSGRQRHGGGEKKTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H659</accession>
    <name>Q2H659_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Arabinogalactan endo-beta-1,4-galactanase</fullName>
            <ecNumber evidence="3 8">3.2.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_05856</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>The enzyme specifically hydrolyzes (1-&gt;4)-beta-D-galactosidic linkages in type I arabinogalactans.</text>
            <dbReference type="EC" id="3.2.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 53 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.89" evidence="3 8"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221951.1">
        <property type="nucleotide sequence ID" value="XM_001221950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H659"/>
    <dbReference type="STRING" id="306901.Q2H659"/>
    <dbReference type="GeneID" id="4390296"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05856"/>
    <dbReference type="eggNOG" id="ENOG502QU6R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011259_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H659"/>
    <dbReference type="OMA" id="KYIHDEW"/>
    <dbReference type="OrthoDB" id="110914at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031218">
        <property type="term" value="F:arabinogalactan endo-1,4-beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000077">
        <property type="entry name" value="Arabinogalactan endo-beta-1,4-galactanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011683">
        <property type="entry name" value="Glyco_hydro_53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34983">
        <property type="entry name" value="ARABINOGALACTAN ENDO-BETA-1,4-GALACTANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34983:SF1">
        <property type="entry name" value="ARABINOGALACTAN ENDO-BETA-1,4-GALACTANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07745">
        <property type="entry name" value="Glyco_hydro_53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005142969" description="Arabinogalactan endo-beta-1,4-galactanase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ89237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="350" mass="38480" checksum="27EC67406A2B9DB2" modified="2006-03-21" version="1">MMLTRFVAALLGLSAADAALTYKGVDWSSVVVEERAGVSYKNVNGNAQPLEKIFADNGVNTVRQRVWVNPRDGNYNLAYNIALAKRAKAAGLGVYIDFHYSDTWADPAHQTTPSGWPTDIDNLSWKLYNYTLDAANQFQAAGVQPSIMSIGNEITPGLLWPTGKTNNWGNIARLLHSAAWGIKDSTLNPKPKIMVHLDNGWNWETQKWWYTNVLQQGTFVSSDFDMMGVSFYPFYSASASLSALKTSLTNMAQTWNKDVAVVETNWPTSCPNPKYSFPSDVKNIPFSAAGQSTYVTNVANVVSSVSRGVGLFYWEPAWIHNANLGSSCADNTMFSPSGQALSSLSVFKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H680</accession>
    <name>Q2H680_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221930.1">
        <property type="nucleotide sequence ID" value="XM_001221929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H680"/>
    <dbReference type="STRING" id="306901.Q2H680"/>
    <dbReference type="GeneID" id="4390030"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05835"/>
    <dbReference type="eggNOG" id="KOG4303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_973187_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H680"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="286" mass="29924" checksum="BC71C0B1DD754D7F" modified="2006-03-21" version="1">MASGRNISGVEVTNRLAALTDIGGVNSIRSFTRSWQRAAGFSEVIPQRPSFVFAPDQAPIAPPPDDAAAGDLSPYSQQQRDIETGTGGSPSLIRQHLEAAFRAGEQHPPRHDSPEPGASISASHGSLLHRSSISDSREGKSLDGNGSGSDPDLLPSIFRIGSHTTTASAGGTSIFAIPPHLATPPLVGSYRSLVSGLDYGTVRSDVSGGGGGDMAHAAALWRQQQEAGGNVPDGELPPILVKEVEQDGKFVLAVEGQSTLPQTVFNSTNYACWVRLLDALVLVADW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6C4</accession>
    <name>Q2H6C4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221886.1">
        <property type="nucleotide sequence ID" value="XM_001221885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6C4"/>
    <dbReference type="GeneID" id="4391168"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05791"/>
    <dbReference type="eggNOG" id="ENOG502R7TI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1288762_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6C4"/>
    <dbReference type="OrthoDB" id="3563866at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="214" mass="23381" checksum="1CCDC0B196C8F061" modified="2006-03-21" version="1">MRLTWQSISSFFSSSVDSPSSGEGFDGQKHKPAPLKSTFGAAVDSSLPSPVESSAPSAASDRDFSAPESPYSNHQASLSRTSTATAPTSPASNQLLLPPHHDGRPHTAPSPAPPSSSSQQEERPLPAQHLENNPPDIMSREFPTPAREPTVEDMFTRPPGKLSLQHWVKNCKMRQVSGERPLNEAEAAERARHFEETKRELMADKEKFASVMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7F2</accession>
    <name>Q2H7F2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_05413</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 13">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221508.1">
        <property type="nucleotide sequence ID" value="XM_001221507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7F2"/>
    <dbReference type="STRING" id="306901.Q2H7F2"/>
    <dbReference type="GeneID" id="4390141"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05413"/>
    <dbReference type="eggNOG" id="KOG0351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001103_9_2_1"/>
    <dbReference type="InParanoid" id="Q2H7F2"/>
    <dbReference type="OMA" id="TRMKTDR"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18018">
        <property type="entry name" value="DEXHc_RecQ4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF120">
        <property type="entry name" value="BIFUNCTIONAL 3'-5' EXONUCLEASE_ATP-DEPENDENT HELICASE WRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="105"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="316"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="30"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ88794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="747" mass="82918" checksum="4998DF27908864F5" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7H7</accession>
    <name>Q2H7H7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221483.1">
        <property type="nucleotide sequence ID" value="XM_001221482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7H7"/>
    <dbReference type="GeneID" id="4389991"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05388"/>
    <dbReference type="HOGENOM" id="CLU_657204_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7H7"/>
    <dbReference type="OrthoDB" id="4587630at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="418" mass="47552" checksum="3ACAA5298B5B1079" modified="2006-03-21" version="1">MSQIKRQKRRSPSPDSSETEDSSSPSPPRSSPSPPWSSSGLCRLLFAERLDTAGYWEPLRTEVRLLGGHLQKWGLLPWPSLDPEVQSRLSSWSPVAKQLWESDFLGHQKAMVQAWIWHYLDDYVFSFAGNQQDGILKLRSPVWEHVQVLRRDLDVLRARDATIHDVVYRHQFQVWNRLTEHLVRGGLEDRESFDQAELVAHFKRSIGRLTILRDKTPDDASDGDHCDAGDASSAVDHFDAAIEGLLKSACHAQYFIHGMDWGYTLRFTPIGPHAGKMFDFPYNPGWMELNNPVEVPSKHPNEVDHPPVQLVSQPMLVASGLKGAKHNTTFTLRTSMCVVTPWTFGGKEARPYVYYGFEKGWELVPFDVRSENQRKYHERKRMEEQQKSQPLVEGLKDGESQATDGHAIDDSVADAPCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7L2</accession>
    <name>Q2H7L2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_05353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221448.1">
        <property type="nucleotide sequence ID" value="XM_001221447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7L2"/>
    <dbReference type="STRING" id="306901.Q2H7L2"/>
    <dbReference type="GeneID" id="4390487"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05353"/>
    <dbReference type="eggNOG" id="ENOG502S8YH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061834_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H7L2"/>
    <dbReference type="OMA" id="GSHEVFN"/>
    <dbReference type="OrthoDB" id="26838at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040:SF1">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ88734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24681" checksum="025F470FBEB85B3A" modified="2006-03-21" version="1">MSSSTSHSIAAKAESARDMIDMVDTTAKLSEMLDTLEGLPTEPPSLYFDLEGENLSRHGSVSILQLHVLPSSRRYLVDVHTLQHTAFSTCGENGLTLKELLESDGILKVFSIGLSRCIERGACLLAAELATWKAVKDAGVKLFSPDYGGSYTVFVERPLCDAIKLYSAQDAQILPRLWSQYNTRMTPVWTRKAHETSKERVALSQTATFNGKGRHMALAPPGWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7P6</accession>
    <name>Q2H7P6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL15/eL18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_05319</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221414.1">
        <property type="nucleotide sequence ID" value="XM_001221413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7P6"/>
    <dbReference type="FunCoup" id="Q2H7P6">
        <property type="interactions" value="519"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H7P6"/>
    <dbReference type="GeneID" id="4391232"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05319"/>
    <dbReference type="eggNOG" id="KOG0846">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055188_5_0_1"/>
    <dbReference type="InParanoid" id="Q2H7P6"/>
    <dbReference type="OMA" id="VVTRYYT"/>
    <dbReference type="OrthoDB" id="361383at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_uL15_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934:SF11">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="115"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ88700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="301" mass="32747" checksum="4E93FF3871074DEB" modified="2006-03-21" version="1">MPPRLPLAQAARCCTAAIEASARPTSLVSLFAALSVQTRSASILASISDNKGAYNKRIRKGRGPSSGYGKTSGRGHKGTGQRGKLNPWFQGGQTALIFSHGKMGFVNHRAPVMMELNLDRLQAWIDAGRLDPKKPITPREIIKSGVIGSSIKDGIKLLARGGETLKTPIDIMVSRASASAIKAVEDAGGKITTRFYTKDSLKRLVNGQSVSTDKPLPFGPEHVEAVLEKARTTKKHYFRLPDPTSREDIEYYRDPAHRGYLSHTLQPGESPSLYFKVPGKTAITNKPKSKEKAAEQAARLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7X7</accession>
    <name>Q2H7X7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_03677</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230193.1">
        <property type="nucleotide sequence ID" value="XM_001230192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7X7"/>
    <dbReference type="GeneID" id="4388723"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03677"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_5_1"/>
    <dbReference type="InParanoid" id="Q2H7X7"/>
    <dbReference type="OMA" id="MAIIVSC"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="67"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ91742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="540" mass="59689" checksum="AD12D2FD96EECA19" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H837</accession>
    <name>Q2H837_CHAGB</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">CHGG_03617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001230132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H837"/>
    <dbReference type="GeneID" id="4389178"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03617"/>
    <dbReference type="HOGENOM" id="CLU_2527249_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H837"/>
    <dbReference type="OrthoDB" id="4186099at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ91682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="84" mass="9217" checksum="6620941214B2E7F9" modified="2006-03-21" version="1">MTRLAVLLCGRLAPAPLSPSPRSSGASEQDLANILRTYNQPTDPSHIYDSVYTCFKQNSVGWVSWCGGPYTCEPITGWPQARCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8E2</accession>
    <name>Q2H8E2_CHAGB</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001230027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8E2"/>
    <dbReference type="GeneID" id="4388713"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03512"/>
    <dbReference type="HOGENOM" id="CLU_1081829_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8E2"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="257" mass="28397" checksum="1C84CD93A1862119" modified="2006-03-21" version="1">MHSTFARCLLCQYIRCWVRWCLEAVKARGAAREAYHFRPRTFELALQQQTQQQQERLLRRMRSVTFRGASTLEEADDGFQKAGKRKRPRGRPPGFLIAQEEAARSSRQGKLTFAGKVDTDLTGDRGDGVGGLGVTTPEATDTLEADGQDVGMQGAGGLDAGSPMRSSGFKGPTSYWESYEPYINAANESMMRVVITPMGLYSDSVSTTVRWRTGIYQLSVTRLTQWNGRALEVTKHGDALSGPHRRTQPPGAAQSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8J3</accession>
    <name>Q2H8J3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8J3"/>
    <dbReference type="GeneID" id="4389427"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03461"/>
    <dbReference type="eggNOG" id="ENOG502T6F7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2170773_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8J3"/>
    <dbReference type="OrthoDB" id="5415741at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="110" mass="12076" checksum="4E385D0B575EA019" modified="2006-03-21" version="1">MATIPRKESTLVERVQALTLHSKGAKTPEIENITGIKKQAFKALLRRARERGYCVGGPIKEEHVVNGPRTGRPTKGATENFTERVREDSEEAILEALTEDSTSSDAIKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8Q1</accession>
    <name>Q2H8Q1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229919.1">
        <property type="nucleotide sequence ID" value="XM_001229918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8Q1"/>
    <dbReference type="STRING" id="306901.Q2H8Q1"/>
    <dbReference type="GeneID" id="4389786"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03403"/>
    <dbReference type="eggNOG" id="ENOG502RXA3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010837_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8Q1"/>
    <dbReference type="OMA" id="NNAFMKT"/>
    <dbReference type="OrthoDB" id="5421842at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="638"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="823" mass="92328" checksum="67D24DFE9B4B4BCD" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9K2</accession>
    <name>Q2H9K2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_03102</name>
    </gene>
    <organism evidence="4 5">
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229618.1">
        <property type="nucleotide sequence ID" value="XM_001229617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9K2"/>
    <dbReference type="ESTHER" id="chagb-q2h9k2">
        <property type="family name" value="FSH1"/>
    </dbReference>
    <dbReference type="GeneID" id="4388893"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03102"/>
    <dbReference type="eggNOG" id="KOG2551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051938_4_1_1"/>
    <dbReference type="InParanoid" id="Q2H9K2"/>
    <dbReference type="OMA" id="ILCLHPW"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF4">
        <property type="entry name" value="ESTERASE ALNB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ91167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="342" mass="37878" checksum="EC984DCCE3EEE9AF" modified="2006-03-21" version="1">MKILCLHPWGTSGFIFEKQLQTLSGILGPTHEYVYINGGVPSARARDLPDFVKGPYYCWYEGLSSPQCQEAHDTITETIKEEGPFDGVIGFSQGASLALSFMLHHELHNPGLPCPFRFALLFCANLVISPDPKFNQDKVVKYSGYYKASRDGVRPAGEVGEEHNDEDNDEDNDDQYKTETGEGNGTHQTVQTTPATPATPLAPDASSSKRRAAPKHRALLLLPGRKKALVEELVDLIDEASHNLSGEADASKHSWPEDPKPEDFPRLMHPLTVKARVPIPTVHVIAQNDPLMRHTELAVRLCDKKKTKLVYFDGPHRIPTAPSTLNAIARAVEWAMQKGQLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAM3</accession>
    <name>Q2HAM3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229247.1">
        <property type="nucleotide sequence ID" value="XM_001229246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAM3"/>
    <dbReference type="STRING" id="306901.Q2HAM3"/>
    <dbReference type="GeneID" id="4389240"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02731"/>
    <dbReference type="eggNOG" id="ENOG502S93S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006885_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HAM3"/>
    <dbReference type="OMA" id="QAQIQMT"/>
    <dbReference type="OrthoDB" id="5396252at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42068">
        <property type="entry name" value="YALI0B18964P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42068:SF1">
        <property type="entry name" value="YALI0B18964P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="751" mass="80603" checksum="FC1EF6904542AB24" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAT4</accession>
    <name>Q2HAT4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229186.1">
        <property type="nucleotide sequence ID" value="XM_001229185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAT4"/>
    <dbReference type="GeneID" id="4389201"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02670"/>
    <dbReference type="HOGENOM" id="CLU_3368418_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HAT4"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="35" mass="3774" checksum="F0BA29E66C12F14C" modified="2006-03-21" version="1">MGGYLGGGGSRPHSQLPSTPMHNGPCYWWQVTRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAY9</accession>
    <name>Q2HAY9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229131.1">
        <property type="nucleotide sequence ID" value="XM_001229130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAY9"/>
    <dbReference type="GeneID" id="4389289"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02615"/>
    <dbReference type="HOGENOM" id="CLU_2249818_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HAY9"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="104" mass="11432" checksum="A61BDE63B6AA26F3" modified="2006-03-21" version="1">MAPTGFLPRSQTSLTGLVAAGSCGKKETSEPETCRGHRYSDTISPPYRDMAAPQSVRAGMACVPAMLRYPISRRDPRREATSWLRDGFFSRRSEISGPPTVDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBC4</accession>
    <name>Q2HBC4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative phospholipase</fullName>
            <ecNumber evidence="4">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_02480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30909"/>
            <dbReference type="ChEBI" id="CHEBI:36707"/>
            <dbReference type="EC" id="3.1.1.47"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine esterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.47" evidence="4"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228996.1">
        <property type="nucleotide sequence ID" value="XM_001228995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBC4"/>
    <dbReference type="STRING" id="306901.Q2HBC4"/>
    <dbReference type="ESTHER" id="chagb-q2hbc4">
        <property type="family name" value="PAF-Acetylhydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="4389564"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02480"/>
    <dbReference type="eggNOG" id="KOG3847">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024458_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HBC4"/>
    <dbReference type="OMA" id="IRACASW"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016715">
        <property type="entry name" value="PAF_acetylhydro_eukaryote"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF7">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018169">
        <property type="entry name" value="PAF_acetylhydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="476"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR018169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ90545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="525" mass="56065" checksum="38DA3D64CB60EBC2" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBC9</accession>
    <name>Q2HBC9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M50B-like-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228991.1">
        <property type="nucleotide sequence ID" value="XM_001228990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBC9"/>
    <dbReference type="STRING" id="306901.Q2HBC9"/>
    <dbReference type="GeneID" id="4389391"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02475"/>
    <dbReference type="eggNOG" id="ENOG502QPXP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066780_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HBC9"/>
    <dbReference type="OMA" id="LSVNHTQ"/>
    <dbReference type="OrthoDB" id="40823at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049500">
        <property type="entry name" value="Peptidase_M50B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979">
        <property type="entry name" value="OS02G0221600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979:SF2">
        <property type="entry name" value="PEPTIDASE M50B-LIKE-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13398">
        <property type="entry name" value="Peptidase_M50B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="30326" checksum="F2E756FA3891CF83" modified="2006-03-21" version="1">MAPPALRPAIASRAWHAAAPHVARASVAASSAALSRRDLTVNDAQKVTLGIIAAYVVVIALLWNLPYIKWILWPFKMLVIAFHEFGHAFACVLTGGRVKSISLDPREGGVTHMQGGRNAITLPAGYLGSSLIGALLTFAGFNINASKIASIVVGVCFLLTLWWGRRDWLTIATVLAAVGLLVGCWFIAHAEALRFVVLFIGVMSSLYSVWDICDDLILRKVNSSDASVFAQRYGGSSQCWGVIWSIISLGFMAAGIVAGIAAFPQSAAQQREDSQHFIPTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBI8</accession>
    <name>Q2HBI8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_02416</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228932.1">
        <property type="nucleotide sequence ID" value="XM_001228931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBI8"/>
    <dbReference type="STRING" id="306901.Q2HBI8"/>
    <dbReference type="GeneID" id="4389436"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02416"/>
    <dbReference type="eggNOG" id="ENOG502QRIP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021264_11_2_1"/>
    <dbReference type="InParanoid" id="Q2HBI8"/>
    <dbReference type="OMA" id="MHETYSS"/>
    <dbReference type="OrthoDB" id="2125469at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF9">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="NodB homology" evidence="8">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ90481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="177" mass="19193" checksum="4AE762E94D4C0EDC" modified="2006-03-21" version="1">MLALAYDDGPVTTTAVKKAFASGHQIASHSWTHGHMGSMSAQQIRTEMTRVEDAMVNLIGKKPAYMRPPYLETSGQFLPTMASMGYKVITNDVDSGDWNNQSPQQSQQAFQRAGAGGNGHIPLMHETYAGTVRTLTPWLINWAKQNNLKLVTVAECLGDANGAYQSGTFTPNGQNSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCB0</accession>
    <name>Q2HCB0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14 15">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="3 14 15">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_02144</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:23733"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="3 14 15"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228660.1">
        <property type="nucleotide sequence ID" value="XM_001228659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCB0"/>
    <dbReference type="FunCoup" id="Q2HCB0">
        <property type="interactions" value="596"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HCB0"/>
    <dbReference type="GeneID" id="4389042"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02144"/>
    <dbReference type="eggNOG" id="KOG2833">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040369_4_2_1"/>
    <dbReference type="InParanoid" id="Q2HCB0"/>
    <dbReference type="OMA" id="LTLHAMM"/>
    <dbReference type="OrthoDB" id="10253702at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000018">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000005">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 15" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="17">
        <location>
            <begin position="12"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="16">
        <location>
            <begin position="199"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR015950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ90209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="394" mass="41488" checksum="8CF126A88C68F9CE" modified="2006-03-21" version="1">MADKVYRASTTAPVNIAVVKYWGKRDSKLNLPTNSSLSVTLSQADLRTLTTASCSASYPASQGDSLLLNGEPSDIAGARTQACFRELRTRREALEAADPSLPQLSTMPLRLVSENNFPTAAGLASSAAGFAALVRAIANLYELPASPSELSLIARQGSGSACRSLFGGYVAWRMGDAADGSDSMADQVAEASHWPDMRALILVVSAAKKGVSSTSGMQQTVATSGLFQERIAKVVPQNMAAMEKAIAERDFASFAEVTMRDSNSFHATCADTYPPIFYMNDVSRAAIRAVEQINAAAGRTVAAYTFDAGPNAVIYYLEKDTEAVVGTLYHVLGGEVGGWKSTVVQGLKPSISLDEGVAGILKAGVSRVILTGVGEGPLKSEEYLVAQDGSPAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCC2</accession>
    <name>Q2HCC2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_02132</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221353.1">
        <property type="nucleotide sequence ID" value="XM_001221352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCC2"/>
    <dbReference type="GeneID" id="4386196"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02132"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="InParanoid" id="Q2HCC2"/>
    <dbReference type="OMA" id="WLMIPFI"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF78">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="20"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="496"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ93897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="532" mass="58221" checksum="284A4EA266A8DF34" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCM3</accession>
    <name>Q2HCM3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_02031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221252.1">
        <property type="nucleotide sequence ID" value="XM_001221251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCM3"/>
    <dbReference type="GeneID" id="4388077"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02031"/>
    <dbReference type="eggNOG" id="ENOG502RQVI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_778454_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCM3"/>
    <dbReference type="OMA" id="WREDCAE"/>
    <dbReference type="OrthoDB" id="2251794at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="356" mass="37638" checksum="0936DFBF23C63784" modified="2006-03-21" version="1">MAVLARGCTRSLELRGQLENSGADASFPLALIHPVLTFSYRLAITVTRSHGPRGTPTTDCNAQMAEMGSLAGSADHNHHSTLEVVPAQDSSKLAFNKNDKVAFVPSHEHDKIAVPPQPYDDASHYQQADAGHWRPQSTPTQDGYTWDGDASDPWAAGEGVGTEKKERILGLKRWVFFAVLGIAALLVAIGVGVGVGVGVSTRPTSNAEADAAASSTSDAGIPATTSGQSATATSRSPTSSAPQSTPSRQVGGVGGRCSENWGSDCICLDETVCSTAWNGTAQTGRKPDWPCPNDPASIKACYVQPCKNAAQLSSRCLWREDCAELDPGKRCLDILAPALDIRCSYMDETLTCKSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCZ5</accession>
    <name>Q2HCZ5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221130.1">
        <property type="nucleotide sequence ID" value="XM_001221129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCZ5"/>
    <dbReference type="GeneID" id="4386499"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01909"/>
    <dbReference type="eggNOG" id="ENOG502QW09">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022148_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCZ5"/>
    <dbReference type="OMA" id="TWEYGNE"/>
    <dbReference type="OrthoDB" id="2796951at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="1">
        <location>
            <begin position="386"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="557" mass="59666" checksum="E694C5718674E514" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDH8</accession>
    <name>Q2HDH8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_01726</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220947.1">
        <property type="nucleotide sequence ID" value="XM_001220946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDH8"/>
    <dbReference type="STRING" id="306901.Q2HDH8"/>
    <dbReference type="GeneID" id="4386829"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01726"/>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_125_8_1"/>
    <dbReference type="InParanoid" id="Q2HDH8"/>
    <dbReference type="OMA" id="IHQRIDH"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056681">
        <property type="entry name" value="DUF7779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25000">
        <property type="entry name" value="DUF7779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="2">
        <location>
            <begin position="66"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7779" evidence="3">
        <location>
            <begin position="277"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ93491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="690" mass="77439" checksum="FB14AFC0B1522181" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDJ3</accession>
    <name>Q2HDJ3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_01711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220932.1">
        <property type="nucleotide sequence ID" value="XM_001220931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDJ3"/>
    <dbReference type="STRING" id="306901.Q2HDJ3"/>
    <dbReference type="GeneID" id="4386989"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01711"/>
    <dbReference type="eggNOG" id="KOG3102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1377973_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HDJ3"/>
    <dbReference type="OrthoDB" id="49151at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034477">
        <property type="term" value="P:U6 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027521">
        <property type="entry name" value="Usb1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09749">
        <property type="entry name" value="HVSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ93476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="198" mass="21358" checksum="35C80DF9A7D15844" modified="2006-03-21" version="1">MGRCAYKDGRGRMRECGPNLSECGGGGGQAVFGLRGSGVVEWHRTGESGRSFLVLRVESLLRRKGLEGGGGDEDAGAGDNPNPELTGLLRRCNAVVKRYGQPGLYEWAEAEDGRANGGRRVGEAFHVSIAWSFAEPRYELVRATERVFGGRDIQQKLREVQIPVEAIKVKIGNGITNVALRRPGARAGREGARNLLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDS3</accession>
    <name>Q2HDS3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220852.1">
        <property type="nucleotide sequence ID" value="XM_001220851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDS3"/>
    <dbReference type="GeneID" id="4387077"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01631"/>
    <dbReference type="eggNOG" id="ENOG502QR7D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023537_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HDS3"/>
    <dbReference type="OMA" id="MMWAKYL"/>
    <dbReference type="OrthoDB" id="7771656at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047:SF2">
        <property type="entry name" value="DUF1237 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="618"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="788" mass="86421" checksum="67A57D34798658B2" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDT2</accession>
    <name>Q2HDT2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histidyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_01622</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="3"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220843.1">
        <property type="nucleotide sequence ID" value="XM_001220842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDT2"/>
    <dbReference type="FunCoup" id="Q2HDT2">
        <property type="interactions" value="771"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HDT2"/>
    <dbReference type="GeneID" id="4387092"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01622"/>
    <dbReference type="eggNOG" id="KOG1936">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025113_4_1_1"/>
    <dbReference type="InParanoid" id="Q2HDT2"/>
    <dbReference type="OMA" id="CGGGNFK"/>
    <dbReference type="OrthoDB" id="1906957at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000015">
        <property type="entry name" value="Histidyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core" evidence="15">
        <location>
            <begin position="15"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon-binding" evidence="14">
        <location>
            <begin position="377"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="288"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="80"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="274"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001549-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAQ93387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="517" mass="57132" checksum="6B15814B28820939" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDU3</accession>
    <name>Q2HDU3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_01611</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220832.1">
        <property type="nucleotide sequence ID" value="XM_001220831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDU3"/>
    <dbReference type="FunCoup" id="Q2HDU3">
        <property type="interactions" value="235"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HDU3"/>
    <dbReference type="GeneID" id="4386523"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01611"/>
    <dbReference type="eggNOG" id="KOG0634">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_5_1"/>
    <dbReference type="InParanoid" id="Q2HDU3"/>
    <dbReference type="OMA" id="HRPEGGM"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008793">
        <property type="term" value="F:aromatic-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF21">
        <property type="entry name" value="AROMATIC_AMINOADIPATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="143"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ93376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="488" mass="53924" checksum="9A08B5D845ECBC02" modified="2006-03-21" version="1">MRSAIRTGAFRGLPPSAPASLHSGIKSVRSAPRRLSVPPPSAFHSKTPDHSEAAAATPKFPEAELTPPPTPQERITIADIKERRARAGRLNAPTAASCNADMFKAPANPKPNDGIATGSAQMTRFAVEHVELVGAPPYADWGVCLTVGSTGALEQALRMLCDGPGRGDTLLTEEFSFSTALETAAPLRVGVVGVGMDGEGLVPERMEEVLARWDVKARGGRAKPRVLYTVPSGQNPTGATQSVERRRAIYEVARRHDVFILEDEPYYYLQMQEPGTEAPKSVEAFLEGLIPTYLSMDVDGRVMRMDSFSKVVVPGSRMGWITASEQIVERFVRHAEVANQGPSGFSQVILHKLLDEQWGHEGYFRWLMNLRMEYTKRRDVMSAACDEFLPREVVSWKPPQAGMFQWLKVNYELHPRAASKSIMEIEEEIYNSCIAKGVLVARGSWFRAEQDVPPSGLYLRATFAAATPENMREAIRRLGEAIRESYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEH8</accession>
    <name>Q2HEH8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220597.1">
        <property type="nucleotide sequence ID" value="XM_001220596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEH8"/>
    <dbReference type="GeneID" id="4387394"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01376"/>
    <dbReference type="HOGENOM" id="CLU_2372587_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HEH8"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="95" mass="10046" checksum="31A677C458A96BC3" modified="2006-03-21" version="1">MLNDEAQIASPSLVGVALTEWGSIPPTKYRTIQRTLLMITITNATPFPGQESRAAVAGATRMPNSKPPPPELALGPSAPQGHRIPISGLSKGRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HES2</accession>
    <name>Q2HES2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_01282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220503.1">
        <property type="nucleotide sequence ID" value="XM_001220502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HES2"/>
    <dbReference type="STRING" id="306901.Q2HES2"/>
    <dbReference type="GeneID" id="4387405"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01282"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_439403_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HES2"/>
    <dbReference type="OMA" id="QHETTSH"/>
    <dbReference type="OrthoDB" id="4588414at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058925">
        <property type="entry name" value="zf-C2H2_AcuF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF7">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26082">
        <property type="entry name" value="zf-C2H2_AcuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="522"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="556"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="590"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="422"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ93047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="622" mass="68437" checksum="5219930A19AE151C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HF48</accession>
    <name>Q2HF48_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_01156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220377.1">
        <property type="nucleotide sequence ID" value="XM_001220376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HF48"/>
    <dbReference type="SMR" id="Q2HF48"/>
    <dbReference type="STRING" id="306901.Q2HF48"/>
    <dbReference type="GeneID" id="4387655"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01156"/>
    <dbReference type="eggNOG" id="ENOG502SVCF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024934_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HF48"/>
    <dbReference type="OMA" id="MEHMELF"/>
    <dbReference type="OrthoDB" id="5350673at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ92921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="336" mass="37310" checksum="316E1E2F865AE91C" modified="2006-03-21" version="1">MLRRSHKKSRAGCLECKRRHVKCDEQRPKCIICTLSDRECGYPPQPAGSSAPSTPAAAIQEEPEPKQSADLAPAITTKNESSASPVAGVPLPDIASRGPMSPNYANQSSPEVNLNHMELLIRFNFEEHAPELNVEMHDFASKLLFKCALEAPYLMHQILAVSARRQALLQPERADHFLETAIHLQTKAVSIYNETGARAQIDQTNCSTLLLFCSLLGRHLLADLLARRDSDFGDFLTRFLEFLSISRGLLAMSVSAWDLLLQSDIKHLVLWALEISQSTPRGNHCDGLQRLVAESKELDVPSKEACMTAIACLQVGFDSLLGGDARNQRYLMVFMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFC6</accession>
    <name>Q2HFC6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arginine N-methyltransferase 2</fullName>
            <ecNumber evidence="8">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_01078</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220299.1">
        <property type="nucleotide sequence ID" value="XM_001220298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFC6"/>
    <dbReference type="FunCoup" id="Q2HFC6">
        <property type="interactions" value="346"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HFC6"/>
    <dbReference type="GeneID" id="4386474"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01078"/>
    <dbReference type="eggNOG" id="KOG1709">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033831_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HFC6"/>
    <dbReference type="OMA" id="YWVVDNY"/>
    <dbReference type="OrthoDB" id="19014at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019702">
        <property type="term" value="F:protein arginine N5-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017408">
        <property type="entry name" value="Arginine_N-MeTrfase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051038">
        <property type="entry name" value="RMT2/GAMT_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026480">
        <property type="entry name" value="RMT2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379:SF1">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038148">
        <property type="entry name" value="Arginine_N-mtfrase-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51559">
        <property type="entry name" value="SAM_RMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RMT2" evidence="10">
        <location>
            <begin position="224"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="44"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="187"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ92843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="464" mass="51422" checksum="986A30548BD620A8" modified="2006-03-21" version="1">MSDPDHDTISSRISPSCPPDNQRVLTAAWAHDLAAVKKLLDTPGKASVQDPITGETPLHAAIRSCGPAPSEENGDGDDNNEGDDPADLEAAKKVVYELLLWGGIWNDVDDRNETPGCVAYRLGRKELYNLCVEAGVRAEMLFGVMEGYEELESMDGEEGEDIEVIDMDVDDGEMVVVGEDGEDAPALVNVKPSGQNKVEGEEEDEEEESKEEEEPRFQPPNDDIEADVTSEAYLRSKLTYSDGKLVDDDGNGVMMAWETDIMRQSVDALLPNKEPGKRILNIGFGMGIIDTMFAETKPSTHHIIEAHPEVLEHISSSGSKFGSAWEESGPAPGAFKVQTGKWQEVCQRLIGEGQIYDAIYFDTFGEDYSQLRKFFTDFIPGLLDGEGRFGFFNGLGADRLICYDVYTKVAELHLTDAGLDVDWNVIDVDMSHLAEAGKGEWEGVKRRYWTLDKQKQCFWLRDNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFG6</accession>
    <name>Q2HFG6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_01038</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60292"/>
            <dbReference type="Rhea" id="RHEA-COMP:15535"/>
            <dbReference type="Rhea" id="RHEA-COMP:15548"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.356"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220259.1">
        <property type="nucleotide sequence ID" value="XM_001220258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFG6"/>
    <dbReference type="STRING" id="306901.Q2HFG6"/>
    <dbReference type="GeneID" id="4387378"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01038"/>
    <dbReference type="eggNOG" id="KOG1079">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004089_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HFG6"/>
    <dbReference type="OMA" id="NCDLQRG"/>
    <dbReference type="OrthoDB" id="6141102at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140951">
        <property type="term" value="F:histone H3K27 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026489">
        <property type="entry name" value="CXC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045318">
        <property type="entry name" value="EZH1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048360">
        <property type="entry name" value="Ezh2_CXC_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040968">
        <property type="entry name" value="EZH2_MCSS_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040595">
        <property type="entry name" value="EZH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041355">
        <property type="entry name" value="Pre-SET_CXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21509">
        <property type="entry name" value="Ezh2-like__CXC_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18600">
        <property type="entry name" value="Ezh2_MCSS_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18601">
        <property type="entry name" value="EZH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18264">
        <property type="entry name" value="preSET_CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51633">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CXC" evidence="9">
        <location>
            <begin position="574"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="711"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="45"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="850"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="850"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="863"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="895"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="921"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="956"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1013"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1044"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1057"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1113"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1136"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1156"/>
            <end position="1165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ92803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1184" mass="130452" checksum="77FCFBD2BD556242" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFN2</accession>
    <name>Q2HFN2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">BAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_00972</name>
    </gene>
    <organism evidence="10 11">
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
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    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <location>
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            <end position="806"/>
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    </feature>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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            <text>urea + 2 H2O + H(+) = hydrogencarbonate + 2 NH4(+)</text>
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        <property type="entry name" value="Urease_gamma_sf"/>
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        <property type="entry name" value="urease_beta"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UREASE"/>
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    </dbReference>
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        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
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    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001222">
        <property type="entry name" value="Urease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="Urease, beta-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="Urease, gamma-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0533">Nickel</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease" evidence="12">
        <location>
            <begin position="411"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="592"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="671"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="567"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="8">
        <location>
            <position position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ92637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="788" mass="85390" checksum="5EB919B16B362F6A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFZ1</accession>
    <name>Q2HFZ1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_00863</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220084.1">
        <property type="nucleotide sequence ID" value="XM_001220083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFZ1"/>
    <dbReference type="GeneID" id="4387343"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00863"/>
    <dbReference type="eggNOG" id="ENOG502SJUN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007003_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HFZ1"/>
    <dbReference type="OMA" id="QFRIIMN"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="346"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="54"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ92628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="824" mass="92982" checksum="35C8276FAC08727C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGD0</accession>
    <name>Q2HGD0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_00724</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219945.1">
        <property type="nucleotide sequence ID" value="XM_001219944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGD0"/>
    <dbReference type="GeneID" id="4386802"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00724"/>
    <dbReference type="eggNOG" id="ENOG502SC9R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010412_4_4_1"/>
    <dbReference type="InParanoid" id="Q2HGD0"/>
    <dbReference type="OMA" id="KQSHARN"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ92489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="70" mass="8112" checksum="6BD42E085F6ABA7A" modified="2006-03-21" version="1">MPKVKCSFEDCKSVAQRIVGDCTFCEGSFCKNHRLLEDHKCQNLEDCKREAFEQNAMQLNKERTQVIKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGG8</accession>
    <name>Q2HGG8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Neutral ceramidase</fullName>
            <ecNumber evidence="5">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_00686</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the neutral ceramidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="5"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219907.1">
        <property type="nucleotide sequence ID" value="XM_001219906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGG8"/>
    <dbReference type="STRING" id="306901.Q2HGG8"/>
    <dbReference type="GeneID" id="4386954"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00686"/>
    <dbReference type="eggNOG" id="KOG2232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011300_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HGG8"/>
    <dbReference type="OMA" id="GTTVQTC"/>
    <dbReference type="OrthoDB" id="191371at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="entry name" value="Neutral/alkaline non-lysosomal ceramidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670:SF1">
        <property type="entry name" value="NEUTRAL CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
        <property type="entry name" value="Ceramidse_alk_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase N-terminal" evidence="8">
        <location>
            <begin position="104"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase C-terminal" evidence="9">
        <location>
            <begin position="651"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="562"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="614"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ92451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="823" mass="89628" checksum="9BBEA694173160B3" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGU4</accession>
    <name>Q2HGU4_CHAGB</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ92325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001219780.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="4386204"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00560"/>
    <dbReference type="eggNOG" id="ENOG502SBHE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_773862_0_0_1"/>
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    <dbReference type="OrthoDB" id="5555533at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037652">
        <property type="entry name" value="Mim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28230">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28230:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19117">
        <property type="entry name" value="Mim2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="358" mass="39339" checksum="22E384ABE5EF8C13" modified="2006-03-21" version="1">MSDMSDMSSSDIIMTPSATSSYILPDASRSSSPDGRRDEDVDSLSSLSTSILDSDSSDLSDAQREWEASLEQLQLLLTMIVMPFAGKFLGRKFAYWSWARYMEWMHNVEIRWTSKGAFNAAGAAEAAASRPGPDAPTATTETKEAQNQRRRKRRKQEPHKNSASLHLTTTLMIVPTPIRNPVTRLFARVGAVDDLQLGGQHDGADKGEERGQGIRAEVDEQGEGDALDEARGEAEEGCEPGEDHDEHGEVDGGGGGARCVQVARDDVADEAGEDDDEEELGRSEDELYPFHGGGLGRGSLSVRRGLSRWRGSFLVGRCAQFCWMCGLREIVDLCDCCGSDEEGTWRKTDNILLPWQCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH57</accession>
    <name>Q2HH57_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_00447</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219668.1">
        <property type="nucleotide sequence ID" value="XM_001219667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH57"/>
    <dbReference type="FunCoup" id="Q2HH57">
        <property type="interactions" value="378"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HH57"/>
    <dbReference type="GeneID" id="4388233"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00447"/>
    <dbReference type="eggNOG" id="KOG3139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_0_3_1"/>
    <dbReference type="InParanoid" id="Q2HH57"/>
    <dbReference type="OMA" id="LCIFARH"/>
    <dbReference type="OrthoDB" id="249099at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="27"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ92212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="199" mass="22294" checksum="431A95E7519FEFFD" modified="2006-03-21" version="1">MAAFSDLSDKVGLGTPKAGLPGELQYIQYQHSLESQYLPSIRALISKDLSEPYSIYVYRYFLYQWGHLCFMALNPIDSSLIGVVICKLEMHASHSTPTLRGYIAMLAVCAQYRGHGVATTLVKMAIDVMANRNADEIVLETEETNIPAMRLYERLGFLRSKKLHRYYLNGNSAYRLVLLLKPTDVDATTDLGPDDEGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH89</accession>
    <name>Q2HH89_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Swiss Army Knife RNA repair protein HAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ92180.1"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018812">
        <property type="entry name" value="SAK_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF23">
        <property type="entry name" value="OB FOLD-CONTAINING PROTEIN, NUCLEIC ACID BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10307">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="56"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="626"/>
        </location>
    </feature>
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        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
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        <location>
            <begin position="485"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="594"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ92180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="626" mass="67878" checksum="DFE4DB39AB0D58F9" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHE4</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CHGG_00360</name>
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        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
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        <lineage>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
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    </dbReference>
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    <dbReference type="InParanoid" id="Q2HHE4"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="157" mass="17203" checksum="7CB2D0EF5DFE1E5E" modified="2006-03-21" version="1">MAHGKKSRGPQEDDRGGKNALAYATKGRPCSGPELNEKYWTSTAKNGGVILAFHLQMAGPRPLWPRSPGRCGGTVRGRYFKNGLSALIAKKAFGPVNDHDPPPARSHCIYNIRQSRSNGLLVSPKMFVEWFHALRLALASGANRVNTTPESYVGFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI03</accession>
    <name>Q2HI03_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00151</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    <dbReference type="eggNOG" id="ENOG502RPSU">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_719609_0_0_1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="384" mass="42335" checksum="80B72840CEB4EF44" modified="2006-03-21" version="1">MSSFSTTKIRANTIHENTMGRYYKGSAEPWDECDWCLAKTGWSQRPCLYRTFPEGLSSLRRKECEDVRTRNAAKRNKTLPKAHRRAMRAAPAAAAEAKHKAIPNSTIRTNITNALVVDGLSNLDERTPLEADGGKDTGTEARTEARTETETKEEVCPLPAVSKPTPKLEHRHANDPRKTQQRQPKSCTGLKGVIDEGVGLSSDDGDVARIHASNWKAWPRGQEPIAADATGEDKEVAELVRQGFIGVEELRVGRDDIGGDVCPCTVRFIEARKKGRRGDNCGRQGVQVVGHGPLHAELESDWWYLDDEAYAQLLSDGGARAGALERNVVLRTCRLKRAAVGGLVISVHNKNLGCGWPARIHGRARPEKQILGGKFLMHLSTYHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HIC6</accession>
    <name>Q2HIC6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91793.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001219248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HIC6"/>
    <dbReference type="GeneID" id="4387733"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00028"/>
    <dbReference type="eggNOG" id="ENOG502RF23">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1476125_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HIC6"/>
    <dbReference type="OMA" id="RSVANAW"/>
    <dbReference type="OrthoDB" id="5403747at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="190" mass="20242" checksum="EBD5FB9BE473C54A" modified="2006-03-21" version="1">MPPKSKYTNRAEDTAGNANGDGPLSVLTAREQTMLLQGLLTVPGFPGGIQIDYPKVAERMGLKNPRSVANAWSLIKGKINAYDKKYREDNNLPSAAEEAAAVAQADDAEDENPAPKKRARASKIISAAAAKSAVAPAPRCRKPAAAAKAPRWPRHSIMGPLSEPLATPGEWEEDEEEAEEEMGAADLGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMX2</accession>
    <name>Q2GMX2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_10682</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EAQ84278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001228608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMX2"/>
    <dbReference type="MEROPS" id="A01.081"/>
    <dbReference type="GeneID" id="4397060"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10682"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035052_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GMX2"/>
    <dbReference type="OMA" id="VECTAIP"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF47">
        <property type="entry name" value="ENDOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01220)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208815" description="Peptidase A1 domain-containing protein" evidence="3">
        <location>
            <begin position="30"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="105"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ84278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="455" mass="49030" checksum="3C7503F3639D88FC" modified="2006-03-21" version="1">MVTAVRVLCGALAVASAVAGMATQRYAEAFKDAPPGISYRVAKGIHPWSSSTKITKASRHVQQLRSVHAGRNTKINPRSAAAILGAHQRLVGGVGYENITTTSAYGTQYAVDSLFNGHRMSLIIDTGSSDTWAVQKNFHCIDYSGEFLPQEICGFGETYPETFQYGLTNPESHMYIQYGDGEIVTGPMGFSDVTVGGITVKQQQVCLANTTYWYGNNQTSGLMGLAFPSLTNAYLGIGQGHDLGSQVQYSPLFTSMVNQGLVDPVFSIAIDRNASSGMLAFGGVAPASGLDTTRTAVLDMIITSVIAIPQTAYQYSFYTIIPDGWYYDQTTNTKKIPYIVDSGTTLNYLPSGLADAINASFDPPAVYLWMYGAYFTSCDASIPQVAVLLDGTKFNISPVDLLYRTLVDPLTGLCMTAIADGGSGPYILGDAFMQNALVVFDVGQAKMRFIPRQHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN11</accession>
    <name>Q2GN11_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_10643</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228570.1">
        <property type="nucleotide sequence ID" value="XM_001228569.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4396028"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10643"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_258486_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GN11"/>
    <dbReference type="OrthoDB" id="3766406at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF6">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="4">
        <location>
            <begin position="912"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="5">
        <location>
            <begin position="1190"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="672"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="412"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="672"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="685"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ84239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1339" mass="150761" checksum="6720348B83CB128B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN49</accession>
    <name>BTN1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Protein BTN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">BTN1</name>
        <name type="ORF">CHGG_10605</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in vacuolar transport and vacuole pH homeostasis. Also required for cytokinesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the battenin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228532.1">
        <property type="nucleotide sequence ID" value="XM_001228531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN49"/>
    <dbReference type="SMR" id="Q2GN49"/>
    <dbReference type="FunCoup" id="Q2GN49">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GN49"/>
    <dbReference type="GeneID" id="4396522"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10605"/>
    <dbReference type="eggNOG" id="KOG3880">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029663_1_2_1"/>
    <dbReference type="InParanoid" id="Q2GN49"/>
    <dbReference type="OMA" id="WLCNWQV"/>
    <dbReference type="OrthoDB" id="5965864at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903826">
        <property type="term" value="P:L-arginine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015819">
        <property type="term" value="P:lysine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018460">
        <property type="entry name" value="Battenin_disease_Cln3_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015974">
        <property type="entry name" value="CLN3_BTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0029">Amino-acid transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="chain" id="PRO_0000256259" description="Protein BTN1">
        <location>
            <begin position="1"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="459" mass="49227" checksum="ECE0823B74249770" modified="2006-03-21" version="1">MNRSPSTSGLLPLPGTPSSSWALYRARLSNMFRNTDVSVVIAFWLFGLINNILYVLVLSAAQDLVGTSVPKGAVLLADVLPSFLTKLVAPYFIHRVPYSVRIAVFVALSCAGMLVVAAAPVEGAVGVKLLGVVLASLSSGGGELSFLGLTHYYGHGSLAAWGSGTGGAGLVGAGLYVVLTGWIGLGVRGSLLVGALLPSVMVVAFWGILPRGPLKGWKGGYERVAEPGEEEDGEEGFEDVPAGAASAGLLAPGPSVAATAYTHHHEGRTGRASFWGNVRRARALFFPYMLPLLLVYVAEYTINQGVAPTLLFPLDQSPFSEFREYYPFYGFLYQLGVFISRSSTPFIRIHHLYLPSFLQVANLVLLTLHAVLNFIPSVYLVFVVIFWEGLLGGAVYVNTFAEIMENVPAEDREFSLGATSVSDSGGICIAGFLGMAMEVWLCRWQVSQGRDYCRRIEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNS3</accession>
    <name>Q2GNS3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228308.1">
        <property type="nucleotide sequence ID" value="XM_001228307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNS3"/>
    <dbReference type="STRING" id="306901.Q2GNS3"/>
    <dbReference type="GeneID" id="4396619"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10381"/>
    <dbReference type="eggNOG" id="ENOG502QPI4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015126_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNS3"/>
    <dbReference type="OMA" id="HKTLDKQ"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42345">
        <property type="entry name" value="TPR_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42345:SF1">
        <property type="entry name" value="VTC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="795" mass="88260" checksum="23FA110F375CB6D8" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GP49</accession>
    <name>Q2GP49_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP synthase subunit beta</fullName>
            <ecNumber evidence="14">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_10255</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="14"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228182.1">
        <property type="nucleotide sequence ID" value="XM_001228181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GP49"/>
    <dbReference type="FunCoup" id="Q2GP49">
        <property type="interactions" value="983"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GP49"/>
    <dbReference type="GeneID" id="4396085"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10255"/>
    <dbReference type="eggNOG" id="KOG1350">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022398_0_2_1"/>
    <dbReference type="InParanoid" id="Q2GP49"/>
    <dbReference type="OMA" id="SMEEGGW"/>
    <dbReference type="OrthoDB" id="14523at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000004">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="187"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAQ83851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="519" mass="55659" checksum="21CB6C463A131D90" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPG0</accession>
    <name>Q2GPG0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_10144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <sequence length="1018" mass="111617" checksum="BBED51CD06455DF4" modified="2006-03-21" version="1"> </sequence>
</entry>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        </source>
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            <end position="16"/>
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            <end position="202"/>
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        <location>
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            <end position="103"/>
        </location>
    </feature>
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            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="202" mass="20101" checksum="22DEFE25133CA0E6" modified="2006-03-21" version="1">MKYTTVLVSLLAVATAAKLPNASPDVSDVVARHDGHNEKNTTTPGDGYDQDLEKRRGGGAGAAGAGGAGGSHSSGAGGSRGGSSGSQSSSGCPGPTCDRRPHSGASALMSLDVGLLVAGLTGAGVEGHKNRYQVPIFTHAMGNGASQSARSVHKVHPVGAGLWPASFHIPTDVGGEPVKKGIAKALGKAQNKSLRMNLSASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
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        </reaction>
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        <subcellularLocation>
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        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227978.1">
        <property type="nucleotide sequence ID" value="XM_001227977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPQ3"/>
    <dbReference type="ESTHER" id="chagb-q2gpq3">
        <property type="family name" value="FaeC"/>
    </dbReference>
    <dbReference type="GeneID" id="4395972"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10051"/>
    <dbReference type="eggNOG" id="ENOG502QU71">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027551_2_0_1"/>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043595">
        <property type="entry name" value="FaeB/C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050:SF3">
        <property type="entry name" value="FERULOYL ESTERASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208320" description="feruloyl esterase" evidence="11">
        <location>
            <begin position="24"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ83647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="285" mass="30693" checksum="6FE9AC30405FFD7A" modified="2006-03-21" version="1">MLGTRNLAAAAMLALAWAGAVIAESSAGCGKTPTIKSQQYTMQVNGKQREYIMKLPDNYDQNHPYRLVFLWHQRGGSATKIVQGENPNAGGVVPYYGLPPLANNSAIFVVPNGLNSGWANNGGEDTTFFDQMVKTIEADLCVDTKLRFATGFSWGGGMSYSLACSRPDMIRAVAVLSGAELSGCQGGTSPVAYYAQHGTSDSVLNVAMGRQLRDRFVKNNGCTPLSSEPQPNGGNSVKTEYKGCKEGFPVTWVIHNGDHNPSQVNQGQSYPFAPANSWEFFSQFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPR5</accession>
    <name>Q2GPR5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_10039</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227966.1">
        <property type="nucleotide sequence ID" value="XM_001227965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPR5"/>
    <dbReference type="STRING" id="306901.Q2GPR5"/>
    <dbReference type="GeneID" id="4396015"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10039"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_333438_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPR5"/>
    <dbReference type="OMA" id="IAIFRDA"/>
    <dbReference type="OrthoDB" id="4850545at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="645"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="182"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ83635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="857" mass="97063" checksum="239BCA7433AD002D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQ84</accession>
    <name>Q2GQ84_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_09870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227797.1">
        <property type="nucleotide sequence ID" value="XM_001227796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQ84"/>
    <dbReference type="GeneID" id="4396182"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09870"/>
    <dbReference type="HOGENOM" id="CLU_3242087_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQ84"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ83466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="43" mass="4952" checksum="DC68B3C10189569C" modified="2006-03-21" version="1">MEIQNTYAVHPLYFGTSMFEDNAMLATRSELVATLQVRMVSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQB5</accession>
    <name>Q2GQB5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="11">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_09839</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Alpha-L-arabinofuranosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 62 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="11"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227766.1">
        <property type="nucleotide sequence ID" value="XM_001227765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQB5"/>
    <dbReference type="GeneID" id="4396875"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09839"/>
    <dbReference type="eggNOG" id="ENOG502QUZT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041805_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQB5"/>
    <dbReference type="OMA" id="QYDDWGG"/>
    <dbReference type="OrthoDB" id="3156236at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08987">
        <property type="entry name" value="GH62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005193">
        <property type="entry name" value="GH62_arabinosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631:SF1">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03664">
        <property type="entry name" value="Glyco_hydro_62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208489" description="Alpha-L-arabinofuranosidase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ83435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="321" mass="34647" checksum="7E1D9C578E230511" modified="2006-03-21" version="1">MRLTRSSLALLATAGSVAGQGCDVPSSYKWTSSGVLAEPKSPWVALKDFTVAPYNGQHLVYATTNDGRNWGSMAFSPFKNWEDMGSATQTGMSQGTVAPTLFHFAPKDIWVLAYQWGPTSFSYKTSSDPTNPNGWSSVQPLFEGKISDSGTGAIDQTVIGDDENMYLFFCGDNGKIYRASMPIGNFPGSFGTQSTIIMSDSTNNLFEAVQVYKIDGQQKYLMIVEAIGSGGRYFRSFTATSLGGDWAPNAASESNPFAGKANGGSNWSNDISHGELVRLSADQTFPVDACNLQLLYQGRDPSSNGEYNALPYRPGLLTLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQK1</accession>
    <name>Q2GQK1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227680.1">
        <property type="nucleotide sequence ID" value="XM_001227679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQK1"/>
    <dbReference type="GeneID" id="4396958"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09753"/>
    <dbReference type="HOGENOM" id="CLU_1578337_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQK1"/>
    <dbReference type="OrthoDB" id="10594514at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="169" mass="16040" checksum="4E0BFDBBF1F4893B" modified="2006-03-21" version="1">MRATSALTLLSTGFSAVTTASGFTAPGTNALNLRYAAPLALLAAAATIPSTALAAPSPHRGGGGGNDDDDDDDDDEGGRGEGRGRGDGKGKGKGKGGGGGGGGTNIFVIIAGGGGKGGGSGGGAGDDAGAVAGGGNNGTNATAGGLMTEPARVKRRRTMGFVDLARHMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQK2</accession>
    <name>Q2GQK2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227679.1">
        <property type="nucleotide sequence ID" value="XM_001227678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQK2"/>
    <dbReference type="GeneID" id="4396957"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09752"/>
    <dbReference type="eggNOG" id="ENOG502RR42">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_984133_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQK2"/>
    <dbReference type="OMA" id="DRTHIEH"/>
    <dbReference type="OrthoDB" id="4590928at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="334" mass="37107" checksum="B2FA528E88475BDD" modified="2006-03-21" version="1">MPLRTLGSLKTSDCPLTPIFNMGPNLRDGDEGQHIMHQHFLPLACSRPITTMGSLLSRPKKPQFKASRPRMRDSEALRRRISLNKETLDRVLQQLGHPAAQQPAHPPTHLDQRGNIDQQVSHDQQVYLDQQVYQTRALSPKATTPYYTRKEQGHEHEQEATTAGKGIGLGIAAPAPFLVPIRQAQVPDLNKPLPPLPTTPTTPTSTTPPTPPTPSPTYTTTTTTRTAVTPAATHTPTTLASSSTLFTTLQAHLDRTHIEHHRQQTLRILESRDRHSYRDRDRDRDRDRDTGAPTPLRLLRPYGRRRLPSIILRRRVGRAGVVRGGGRGGGGGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQP3</accession>
    <name>Q2GQP3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227638.1">
        <property type="nucleotide sequence ID" value="XM_001227637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQP3"/>
    <dbReference type="STRING" id="306901.Q2GQP3"/>
    <dbReference type="GeneID" id="4396098"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09711"/>
    <dbReference type="eggNOG" id="ENOG502SYMB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120594_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQP3"/>
    <dbReference type="OMA" id="DGHYSTI"/>
    <dbReference type="OrthoDB" id="5211263at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="157" mass="17640" checksum="8A2A05A9093239DC" modified="2006-03-21" version="1">MASSLDLDQVLYARAGWRKAILIPLWIFQVTVLLGLMGIFAYRLAETFEHYEEHDKLGEMPIVEVVWEATNVGFNLIALLLNILEIARKATERLTPFTMVCTHVIKLTLAFAVLALDIVAYLQRIDGHYSTIGLSLDCGLLYLPLPPSTTPPYTHPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRP8</accession>
    <name>Q2GRP8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_09356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227283.1">
        <property type="nucleotide sequence ID" value="XM_001227282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRP8"/>
    <dbReference type="STRING" id="306901.Q2GRP8"/>
    <dbReference type="GeneID" id="4395905"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09356"/>
    <dbReference type="HOGENOM" id="CLU_1440892_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRP8"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ85342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="188" mass="20444" checksum="ED26922BBE3DDA41" modified="2006-03-21" version="1">MRVQGTVSALFQSNITPETALISYLQAIFFRNATTEEVAGLVATYPKNRDTLAGVGASNSTYPEFKRLAAILGNWEFILMSRLLLETFPADVPASSYSAAYGRGASYPGQVPSRHMSPMVGLSVRVAAPCASEMLRIHAHDYPRLSGPAPPPAASCQRRRRHTWLDPRMLVGLDVREGRKDALAAALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSH3</accession>
    <name>Q2GSH3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta-xylosidase C-terminal Concanavalin A-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_09081</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227008.1">
        <property type="nucleotide sequence ID" value="XM_001227007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSH3"/>
    <dbReference type="SMR" id="Q2GSH3"/>
    <dbReference type="STRING" id="306901.Q2GSH3"/>
    <dbReference type="GeneID" id="4395639"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09081"/>
    <dbReference type="eggNOG" id="ENOG502SIVT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_826393_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSH3"/>
    <dbReference type="OMA" id="IWANTIR"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18833">
        <property type="entry name" value="GH43_PcXyl-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF17">
        <property type="entry name" value="BETA-XYLOSIDASE C-TERMINAL CONCANAVALIN A-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208147" description="Beta-xylosidase C-terminal Concanavalin A-like domain-containing protein" evidence="6">
        <location>
            <begin position="17"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="4">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ85067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="37953" checksum="0CFE3B3D91A686CC" modified="2006-03-21" version="1">MLLTSLLLGLSTCVSASRGHGQNSTFYNPIFPGFYPDPSCIYVPERDHTFFCASSSFNAFPGIPIHASKDLQNWKLIGHVLNRREQLPRLAETNRSTRFYDDTFWLVTTMVDDDRAQEDSSRWDNIIFKAKDPYNPRSWSNAVHFHFTGYDTEPFWDEDGKAYITGAHAWKVGPYIQQAEVDLDTGAVGEWRIIWNGTGGMAPEGPHIYRKDGWYYLLAAEGGTGVDHMVTMARSKKVSGPYESYSKNPVLSNANTTSYFQTVGHADLFHDRNGNWWAVALSTRSGPEYLHYPMGRETVMTAVSWPKGEWPTFTPISGKMSGWPMPPEQKDIRGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSN8</accession>
    <name>Q2GSN8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PhoD-like phosphatase metallophosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_09016</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226943.1">
        <property type="nucleotide sequence ID" value="XM_001226942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSN8"/>
    <dbReference type="STRING" id="306901.Q2GSN8"/>
    <dbReference type="GeneID" id="4394992"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09016"/>
    <dbReference type="eggNOG" id="ENOG502QU5W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015982_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSN8"/>
    <dbReference type="OMA" id="SCANWEA"/>
    <dbReference type="OrthoDB" id="9992270at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032093">
        <property type="entry name" value="PhoD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052900">
        <property type="entry name" value="Phospholipid_Metab_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606:SF8">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16655">
        <property type="entry name" value="PhoD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208573" description="PhoD-like phosphatase metallophosphatase domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase D N-terminal" evidence="3">
        <location>
            <begin position="65"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="2">
        <location>
            <begin position="206"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ85002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="627" mass="69869" checksum="9E66CAD4E54E9BAF" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSU8</accession>
    <name>Q2GSU8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RanGTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226883.1">
        <property type="nucleotide sequence ID" value="XM_001226882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSU8"/>
    <dbReference type="FunCoup" id="Q2GSU8">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="GeneID" id="4395018"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08956"/>
    <dbReference type="eggNOG" id="ENOG502R7I3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014536_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GSU8"/>
    <dbReference type="OMA" id="WDPYNES"/>
    <dbReference type="OrthoDB" id="512915at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008812">
        <property type="entry name" value="Ran_GTP-bd-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31010:SF2">
        <property type="entry name" value="RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31010">
        <property type="entry name" value="RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN 30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05508">
        <property type="entry name" value="Ran-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="624" mass="69727" checksum="FDA900D6F34EC85F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GT10</accession>
    <name>Q2GT10_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226821.1">
        <property type="nucleotide sequence ID" value="XM_001226820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GT10"/>
    <dbReference type="STRING" id="306901.Q2GT10"/>
    <dbReference type="GeneID" id="4395286"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08894"/>
    <dbReference type="eggNOG" id="ENOG502RNRN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_745964_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GT10"/>
    <dbReference type="OrthoDB" id="3439669at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="371" mass="42731" checksum="A9EBBD949D672C85" modified="2006-03-21" version="1">MAGNASGPGQGPPIGPSEALHCVNPQCTRREGMLRAEVDRLNVRIQELRIESQGKTRDIRQLKEEKSDLERENNTLKARRSGQGKHTERQYTRNYRLSCKEENMSSRTPMVHPDIKFVGPRRLAQHNPGSETDSSDVEGEEAPEVVLEDDNTQPPEEFPSDEELAENRSGLPHRFYWGEREMNLSEDGAKPEDVLSILTVSRRFYFIGVHLFYGLNTFAFSSLGELGRFCQGSGLARIARIQHVEVFLTGNQYLTTPLDTRNKRPFSRRSFPMTWLIDMYRLKTLVIHLNETGKQYIRRGYEAPTIKKFLAAKTAGQPNQRMTRSLRCLQGLDYIYQLRGLEWIRFYDFAKVLKTGRSVRKPVQDWSFVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GT33</accession>
    <name>Q2GT33_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226798.1">
        <property type="nucleotide sequence ID" value="XM_001226797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GT33"/>
    <dbReference type="GeneID" id="4395631"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08871"/>
    <dbReference type="HOGENOM" id="CLU_921338_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GT33"/>
    <dbReference type="OrthoDB" id="4179406at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="302" mass="32918" checksum="2CBC2C554A4BDB66" modified="2006-03-21" version="1">MRTKVVGGPLALLMAWCALLLWLTIVDKPCVAGALLGNFLHYISTYQCLPTSLRAFLQTLLRWLCKLHNAPPRVARWLGSPSNPLKPLGRVCRWPLIAYAAWLGVTYTTLLVYYHRRDALSTVVCATPYVVPQLVLCQPLGLPTPDLLAGIPQARGGFAGAMKQLLHEADALLTILRNIHANLDHIKTSAISIKGLSSTSTHTVLQDLWVFIVGKETGAEIKGHKKLLGKIPLFYDAASAAVRDIQSSLLQAKAEMKSLASLPHIKGGHSPRSMPPSTRRNHAAEVRGGAGGEHAEVRREEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTD5</accession>
    <name>Q2GTD5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226696.1">
        <property type="nucleotide sequence ID" value="XM_001226695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTD5"/>
    <dbReference type="GeneID" id="4395743"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08769"/>
    <dbReference type="eggNOG" id="ENOG502RYMG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_773865_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTD5"/>
    <dbReference type="OrthoDB" id="202545at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044:SF2">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="358" mass="39700" checksum="A759B3C3C9593142" modified="2006-03-21" version="1">MPTPTPTPTPLTYIPPLLDGASGTTPHAQHPLLTTLHHELTQTLPILPTLCRALLLHRLLPHRLHPHPVVPASWADTAETALYFLLACFEVEGGGAWWWGVGNGWMMGQEVVEDEKVAVLGGDGDERCFSMPSQVRRTLYSQMRSALLDDSMNRCVVLCHNDSAVIVSQAVTQLCADLPSEKLRKLEIYTFGAAASEFMMPLGDKSMEPESVHHAGDHTNERRGIHIEHFAMTKDPFAQMGVLQSVGRNMKSRFCGGVFVMNDTTPTMQTARPKVMPTCSGYSHGGLPYGSLPKPNGPGQPHHGAQRSRQCHDHRQRLRREARDCGHEQLPRSVPDQKWWEAAQLDRACDHGPGRRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU72</accession>
    <name>Q2GU72_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226409.1">
        <property type="nucleotide sequence ID" value="XM_001226408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GU72"/>
    <dbReference type="STRING" id="306901.Q2GU72"/>
    <dbReference type="GeneID" id="4395161"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08482"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_271055_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GU72"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="62"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="546"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1198" mass="134212" checksum="B2B3D8219294F9C5" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU80</accession>
    <name>Q2GU80_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Meiotic recombination protein DMC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226401.1">
        <property type="nucleotide sequence ID" value="XM_001226400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GU80"/>
    <dbReference type="GeneID" id="4395516"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08474"/>
    <dbReference type="eggNOG" id="ENOG502QZN7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062681_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GU80"/>
    <dbReference type="OrthoDB" id="5420410at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031349">
        <property type="entry name" value="Tfb6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37781:SF1">
        <property type="entry name" value="ADR380WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37781">
        <property type="entry name" value="TFIIH COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17110">
        <property type="entry name" value="TFB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="21981" checksum="1C72891C4DFA72F1" modified="2006-03-21" version="1">MADISRGFVKRAGRSPDKNDPGYQLGDDEGYTSIDGLCRDLDPVIHLVWRSGTPSLQIPSLLSIATEFNTWMIGFPPSPDHIFPLLRKLDHCFASLLAGEDIVTHESLPGFENGLRGGMSTTDMIRCRSTALDARTVIMAVLGRMEQREGGDGEGESGVDDDDDQDLEAHYMDAARVYEYTLVKLGETLGGSGVADVPMMAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUF5</accession>
    <name>Q2GUF5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226326.1">
        <property type="nucleotide sequence ID" value="XM_001226325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUF5"/>
    <dbReference type="GeneID" id="4395041"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08399"/>
    <dbReference type="HOGENOM" id="CLU_2454527_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUF5"/>
    <dbReference type="OrthoDB" id="10432363at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="89" mass="9451" checksum="3145095AA2AD053F" modified="2006-03-21" version="1">MQTSSNEEAKSNTSNTSKTSNNKSQSDPNKPSPALVRWFAEKPGEQPFSGLAGVTIVKGNPSHGEEAASPLGVELESELSCDLDDKKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV78</accession>
    <name>Q2GV78_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 58</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_08126</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for pre-18S rRNA processing. May bind microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225782.1">
        <property type="nucleotide sequence ID" value="XM_001225781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV78"/>
    <dbReference type="SMR" id="Q2GV78"/>
    <dbReference type="FunCoup" id="Q2GV78">
        <property type="interactions" value="1385"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GV78"/>
    <dbReference type="GeneID" id="4394487"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08126"/>
    <dbReference type="eggNOG" id="KOG2572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015495_5_0_1"/>
    <dbReference type="InParanoid" id="Q2GV78"/>
    <dbReference type="OMA" id="MGMRSNW"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017069">
        <property type="term" value="F:snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902570">
        <property type="term" value="P:protein localization to nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000003">
        <property type="entry name" value="Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="8">
        <location>
            <begin position="259"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="445"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="512"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="556"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ86873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="578" mass="63713" checksum="84DF4E7636B5453E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVF2</accession>
    <name>Q2GVF2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225708.1">
        <property type="nucleotide sequence ID" value="XM_001225707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVF2"/>
    <dbReference type="GeneID" id="4393944"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08052"/>
    <dbReference type="eggNOG" id="ENOG502RJ0Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_830448_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GVF2"/>
    <dbReference type="OMA" id="MGRWEAS"/>
    <dbReference type="OrthoDB" id="4583756at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="338" mass="37986" checksum="42C389F0E96AE8CF" modified="2006-03-21" version="1">MPTRARMPGNLGALVTVEDVVGVLELGAHILGFLDDLEDLRNAALTSRRFNRAAQFYLWAAIKPPYLYADPRWADRRPFWDRFAPFLQRNTTSLRVEMRVVAPGLFREISMGRWEASASTAASARWLLAKEGVDSFFTGLKEVLTRTPRLRNFVARDVPRVLDLVDLLHRHHPQLAALDITASRDDTFGFLSVPAYNLDEWKFRVRNDPSYTIPLGNTVNFGLDIHLAPGVQFHQPARPAPQQHSAADSQPLRLKTLTLGYGFEIHDKVSIQHVGPLPRPHSLESLTDLTVLEGLHMDGLHNKDGSQIIELGQDHSYSLISARIPPGVNQLPQLHKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GW36</accession>
    <name>Q2GW36_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_07818</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225474.1">
        <property type="nucleotide sequence ID" value="XM_001225473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GW36"/>
    <dbReference type="GeneID" id="4393668"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07818"/>
    <dbReference type="HOGENOM" id="CLU_1618808_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GW36"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000837">
        <property type="entry name" value="AP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351:SF24">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351">
        <property type="entry name" value="FOS TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="73"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="11"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="91"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ86565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="164" mass="18236" checksum="9B91D220C8AD730F" modified="2006-03-21" version="1">MEADYWAFFGLVPPSNHATDTDTPRDGTERSCYGPTPMPELQRQQSVGENTNGPICTSSTRTGRPGPTKAGAKRRRVRDKVQNRLAVAKSREKKKWELEQKQNHLEDLEKTNSRLKADLISLTDEMYQLRQDLMAHGGCGDADIDTCIKSQGGSNKTPRSESSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GW64</accession>
    <name>Q2GW64_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2-oxoglutarate reductase</fullName>
            <ecNumber evidence="4">1.1.1.399</ecNumber>
            <ecNumber evidence="5">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_07790</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.399" evidence="4"/>
    <dbReference type="EC" id="1.1.1.95" evidence="5"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225446.1">
        <property type="nucleotide sequence ID" value="XM_001225445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GW64"/>
    <dbReference type="FunCoup" id="Q2GW64">
        <property type="interactions" value="571"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GW64"/>
    <dbReference type="GeneID" id="4394332"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07790"/>
    <dbReference type="eggNOG" id="KOG0068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_9_1_1"/>
    <dbReference type="InParanoid" id="Q2GW64"/>
    <dbReference type="OMA" id="SKGCWEV"/>
    <dbReference type="OrthoDB" id="1621027at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061759">
        <property type="term" value="F:2-oxoglutarate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12176">
        <property type="entry name" value="PGDH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000036">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000041">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008759">
        <property type="entry name" value="PRK11790.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="15">
        <location>
            <begin position="402"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAQ86537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="472" mass="51480" checksum="24B447DADD883B33" modified="2006-03-21" version="1">MTTPRDISRSSLGNTVSYSLEAASPTAAFSSPPASQGSFMAGSFANRTAATAKQLKPFNAGDIKILLLENVNQTGRDILAAQGYQVEFLKTSLPEDQLIEKIREVHVIGIRSKTKLTAKVLQEAKNLLVVGCFCIGTNQVDLDYAAKHGIAVFNSPFANSRSVAELVIAEIITLARQLGDRSLEMHRGTWNKVSAKCWEIRGKTLGIIGYGHIGSQLSVLAEAMGMSVIYYDVLTLMAIGSARQVPTLEKLLEEADFVTLHVPETPETKNLISTKEFESMKTGSYLINASRGTVVDIPALIKAMRAGKVAGAALDVYPNEPAANGDYFVNNLNTWAEDLRGLNNIILTPHIGGSTEEAQRAIGVEVADSLVRYINQGITLASVNLPEVTMRSITLEEHDHARVIYIHRNVPGVLRKVNEILAEHNVDKQISDSKGDIAYLMADVSDVKTQDIKDIRDSLDSLNSRIMTRVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GW90</accession>
    <name>Q2GW90_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RFX1-4/6/8-like BCD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_07764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225420.1">
        <property type="nucleotide sequence ID" value="XM_001225419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GW90"/>
    <dbReference type="STRING" id="306901.Q2GW90"/>
    <dbReference type="GeneID" id="4393116"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07764"/>
    <dbReference type="eggNOG" id="KOG3712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011526_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GW90"/>
    <dbReference type="OMA" id="MIWLREN"/>
    <dbReference type="OrthoDB" id="10056949at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR RFX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX1-4/6/8-like BCD" evidence="2">
        <location>
            <begin position="437"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="732"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ86511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="832" mass="92124" checksum="86F2EF8857B6C82F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWM2</accession>
    <name>Q2GWM2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_07632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225288.1">
        <property type="nucleotide sequence ID" value="XM_001225287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWM2"/>
    <dbReference type="GeneID" id="4393839"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07632"/>
    <dbReference type="eggNOG" id="ENOG502RQG0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054623_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GWM2"/>
    <dbReference type="OMA" id="DYISCEN"/>
    <dbReference type="OrthoDB" id="5346581at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ86379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="307" mass="35493" checksum="BCB93C38ECED5706" modified="2006-03-21" version="1">MASTSGTSPFPTSLSGVEMLDVQHRDAVTRAVLRLLDTEIARQTYGQIIDGVPLCGVARAFQEATPDSRPFQLRLIELTAVTLHQIAVVLYKRNLRLHDRHITNPRNSVDQLTWWRQVGDDEGDDKFPPVYRPEPWPTLFTHPQYCDYPQYPDGLADNVGYWAEDQIFGGVVLFDRSQPWNTPAADALTSPEPNLYLHPARYGFTRRLWQVKDEEQRALLEFLLSPTPAAASSYQPGANGPLPLLPTSDHRVRIDPHYAMFRHRVYRDIWERPEPTDEDCYFWDRRPRNSTDYPEVEDEFRSWGLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWQ5</accession>
    <name>Q2GWQ5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_07599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225255.1">
        <property type="nucleotide sequence ID" value="XM_001225254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWQ5"/>
    <dbReference type="GeneID" id="4393739"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07599"/>
    <dbReference type="HOGENOM" id="CLU_1089902_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWQ5"/>
    <dbReference type="OrthoDB" id="4177236at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ86346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="28620" checksum="A810DBA8A37BC865" modified="2006-03-21" version="1">MAKSSPRSPFPSVLDILVETSSLCALEKVTTPATRPKLPYRVPDELLPAPLPSVAEILAAPKVGSHREGDVPIYRVGEHFAVKYSPTDVHAGVYPRMAPRRYIGYAGSAGKFHANGSNNDRTRTRLPRGHTRLTSSGLRPCCVTSPRSMLIFLAEFQAVQRAYRKVFNGHNESVFTHADLVGRNLILRKDGTVVMVNWQNAGWYPVYWEYCCSDVYGRRFDRTGSSWGSELAGMLDEYFAEADLMTRHKDYNYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX58</accession>
    <name>Q2GX58_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225102.1">
        <property type="nucleotide sequence ID" value="XM_001225101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX58"/>
    <dbReference type="GeneID" id="4393794"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07446"/>
    <dbReference type="eggNOG" id="ENOG502SHBW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030671_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GX58"/>
    <dbReference type="OMA" id="AMPLQCS"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF10">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="36889" checksum="613A41E95635C2DE" modified="2006-03-21" version="1">MDPSSVPDFDDLPKVEGQPQGCAWGIFDKDGKKDVLGTLNFLTPKIVAEAAAEVKDGVSISLNWPLNGIKFPLPGRKPPVHRPHRLRDLGMDCEGWDDELEFNTQFSSQWDSLCHVTTDGTTYNGLKPTPEGLSVQSTAENNLPTIEHWHSRGALAGRGVLIDWKRYHEETTGTPYHPLDGYRITVEDIEKVAKHQGVEFKHGDILIIRTGYTEMLEAPTPADFAKFQAGTLSGVHGHADTARWVWNHRFAAVAGDAHGFEAIPALKPDGTPGGVSDLVLHPWFLNQFGMSIGELWDLKALGEYAKKTGRYSFLLTSAPLNHPGLVASPPNAIALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXC2</accession>
    <name>Q2GXC2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225038.1">
        <property type="nucleotide sequence ID" value="XM_001225037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXC2"/>
    <dbReference type="GeneID" id="4393531"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07382"/>
    <dbReference type="eggNOG" id="ENOG502SBBK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125059_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GXC2"/>
    <dbReference type="OMA" id="ERPIMAP"/>
    <dbReference type="OrthoDB" id="5399555at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="117" mass="12999" checksum="D3FB72AE70399D4C" modified="2006-03-21" version="1">MPASLESSRPIMAPSTRTSVRFSTYSMAAPSVTPTVLSTDSVTAEIRPIVDGLERLKNPHLSEQRVFLNEEKTTKLAKLALGAKLERALDRRMTSQDAVMRPRKPSVLEVTSEKEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXJ1</accession>
    <name>Q2GXJ1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_07313</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224969.1">
        <property type="nucleotide sequence ID" value="XM_001224968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXJ1"/>
    <dbReference type="STRING" id="306901.Q2GXJ1"/>
    <dbReference type="GeneID" id="4394067"/>
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    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GY10</accession>
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                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        </source>
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        <location>
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            <end position="26"/>
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        <source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYG5</accession>
    <name>Q2GYG5_CHAGB</name>
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        <recommendedName>
            <fullName evidence="9">MSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="10" type="ORF">CHGG_06989</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.</text>
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    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_437416_0_0_1"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Ig-like_fold"/>
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    </dbReference>
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        <property type="entry name" value="VAP"/>
    </dbReference>
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        <property type="entry name" value="Znf-CCHC_6"/>
    </dbReference>
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        <property type="entry name" value="AT11025P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208725" description="MSP domain-containing protein" evidence="8">
        <location>
            <begin position="24"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="605"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="9">
        <location>
            <begin position="319"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="473"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="567"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ85736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="625" mass="68630" checksum="BEEE7B05148A3B0F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYV8</accession>
    <name>Q2GYV8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_06846</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224502.1">
        <property type="nucleotide sequence ID" value="XM_001224501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYV8"/>
    <dbReference type="STRING" id="306901.Q2GYV8"/>
    <dbReference type="GeneID" id="4394379"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06846"/>
    <dbReference type="eggNOG" id="KOG0071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
    <dbReference type="InParanoid" id="Q2GYV8"/>
    <dbReference type="OMA" id="GGQISKM"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110115">
        <property type="term" value="C:Cdr2 medial cortical node complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051523">
        <property type="term" value="P:cell growth mode switching, monopolar to bipolar"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="110"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAQ85593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="170" mass="19164" checksum="8503DBE6033F1E06" modified="2006-03-21" version="1">MGASMSISSLFGKLFGSKEVRILMLGLDAAGKTTILYKLKLNQTMTTIPTVGFNVEAFTYKNIKFNMWDVGGQDKIRPLWRHYYSDVKTELHRILNDLEMSDCLLLVFANKQDLKGAMDCQTITTKLELSKLGERPWFVQPAIATEGEGLTEGFGWLSENIKKTPKYSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYX7</accession>
    <name>Q2GYX7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_06827</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224483.1">
        <property type="nucleotide sequence ID" value="XM_001224482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYX7"/>
    <dbReference type="STRING" id="306901.Q2GYX7"/>
    <dbReference type="ESTHER" id="chagb-q2gyx7">
        <property type="family name" value="AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="4393589"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06827"/>
    <dbReference type="eggNOG" id="ENOG502RZ4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013364_5_0_1"/>
    <dbReference type="InParanoid" id="Q2GYX7"/>
    <dbReference type="OMA" id="RYWGISG"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208739" evidence="3">
        <location>
            <begin position="19"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="165"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="5">
        <location>
            <begin position="393"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ85574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="498" mass="53740" checksum="5E507B96BF99A1C7" modified="2006-03-21" version="1">MPSTKSLLLALGISAVQAVPKPQGGEGIQWGKCNIETKGLPVECATLPVPLDYSNDSCGDTLDLALIRYPAQNGPSQGTIILNFGGPGQDGLNNMISYAPIQGPWDPRGTGKTLRFACFDPEEIGLTLAYELPDESPEVRQRVWDEAGYIAGNCSERLGDTGDLVGMAFTVRDMFQIVDALNEDGKLRYWGISGGTTLGATAAAMFPNRIDKVVLDGVMNAHEYYHSVGETNIVISADDTFLGFIRACFDNPKKCPLTAVADSADTALDAIVNTFEKLKTEPLLIPVENADPIPISYSIANSFTLSTLYRPNSYQLLAAILTAVIQEDTDALVEAFSGEGGPRAVPQEAQAVMGIRCGDKIPREDELSDLNEVDKKFRDTSKYFPGFGVGYYVYACAQWGFVAKERYDGDFRVRTSSPLLFIGNTYDPVTPLASAQNMSVGFEGSVLLQQDGFGHTSIAQTSNCTNEAIAKYFADGTLPKEGTICATNDPLFANDEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZD8</accession>
    <name>Q2GZD8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224322.1">
        <property type="nucleotide sequence ID" value="XM_001224321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZD8"/>
    <dbReference type="GeneID" id="4391577"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05108"/>
    <dbReference type="HOGENOM" id="CLU_1434288_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZD8"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="189" mass="20069" checksum="8C45DCDE6683DE98" modified="2006-03-21" version="1">MHRLEGPGVEAEREQDGLVVQLAADGRQQRHATASRRLRRVVFQAYPGVLGLAENAAIETAFGRLVTAVAVFDLQPSSPLLEAHVDLADGEDEFEDLVTEFGREAEERGELLVACPSVPGVLSATGGLIALNRERTESEPTDSANSSTPSRPMWVVPGPSSLEVGNLASTALAGLHSHVTTCTHPKSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H045</accession>
    <name>Q2H045_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cut9 interacting protein Scn1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224065.1">
        <property type="nucleotide sequence ID" value="XM_001224064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H045"/>
    <dbReference type="FunCoup" id="Q2H045">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="GeneID" id="4391847"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04851"/>
    <dbReference type="eggNOG" id="KOG3020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_3_0_1"/>
    <dbReference type="InParanoid" id="Q2H045"/>
    <dbReference type="OMA" id="VPCFGWH"/>
    <dbReference type="OrthoDB" id="413993at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053044">
        <property type="entry name" value="Metallo-hydrolase/TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345:SF1">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="49825" checksum="C0CBB66002390351" modified="2006-03-21" version="1">MCNPNDTQSASAVPEQNEGHLDDFPWHIGVCDAHCHPTDTMSSVASVGSMRVRALTIMATRSQDQDLVATAAVKNPIRDRSVLASPAKQDTPDKIIPAFGWHPWFSYQLYDDTETSTASPETTDQHKTQHYRSVLSPQPDDAFIASLPNPIPLSSFLADTRQRVLDAGTALVGEVGLDKAFRLPWPWGIKDPAAAAEHTTTTTEAEAEAEASAPSRRDETLTPGGREGRMLSPHHVKMAHQIRVLQAQLRLAGELGVAVSIHGVQAHGVLFDALAALWKGHEREVVSRKKQKMVAAGAEDFSSSSEDEDEGGEWWGEEGSGGGGGGGGPSQPAKVKEKKKKDYKPKPFPPRVCLHSYSGSPQMMQQYLHPAIPLRTFFSLSTVINLSTAGGENKFADVVRACPDDRLLVESDLHCAGEEMDRVLENISRRICAVKGWTLEEGLTRMRKNYEEFIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H178</accession>
    <name>Q2H178_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_04468</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223682.1">
        <property type="nucleotide sequence ID" value="XM_001223681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H178"/>
    <dbReference type="STRING" id="306901.Q2H178"/>
    <dbReference type="GeneID" id="4393084"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04468"/>
    <dbReference type="eggNOG" id="ENOG502S13M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095018_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H178"/>
    <dbReference type="OMA" id="IRMDFEA"/>
    <dbReference type="OrthoDB" id="5546837at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36460">
        <property type="entry name" value="UPF0132 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G10255)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36460:SF1">
        <property type="entry name" value="UPF0132 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G10255)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ87849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="246" mass="26713" checksum="B611E4430AFF0634" modified="2006-03-21" version="1">MDFAPYQSSPPEHARSPTHSTTASPRTSLENTNNNPNRRGAYSPATGHHYQHRQAAISPPPLQHPQPQRAWSSEGVGRYQSPLAVPGNATSAADLGDGDGNGNGSAGNGGSPWGGRGGGVGDYFSSLGAREGMVSEFDTSLGLRLDYEACLAYLVAPPLGAILLLILERNSDYVRFHAWQSSLLFTALFVLHLLFSWSTFLSWVIFLADLPLIAWLVFNAYRDADTLDRYEVPIIGRIASRILDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1X9</accession>
    <name>Q2H1X9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223431.1">
        <property type="nucleotide sequence ID" value="XM_001223430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1X9"/>
    <dbReference type="FunCoup" id="Q2H1X9">
        <property type="interactions" value="713"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H1X9"/>
    <dbReference type="GeneID" id="4392247"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04217"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H1X9"/>
    <dbReference type="OMA" id="YMECHDS"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="2">
        <location>
            <begin position="28"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="356" mass="38886" checksum="32084DCDC62B12AA" modified="2006-03-21" version="1">MGPAPYNDALTIVTSDNLTSSAPFSCIIDFTPLISEGCDPRPLSRRPPAASPNAPGIHNAAQVAAWRKVTDAVHAKGGYIFCQLWSLGRAADAAVAEKEGFRVHSSSAVPMPEPEDAPVPVAMTVEEIKVRVGEYAHAARCAIEAGFDGVEIHGANGYLIDQFLQDTCNQRTDEYGGSVENRSRFALEVVQAVVDAVGAERTAIRLSPWTRFQGMRMKDPIPQFSDIIRKINRFGLAYLHLVQRRVETSDAESVTVDGESLDFAAELWDGPLLIAGSITPQNARELVDGQFKNKIVVATFGRYFISTPDLPFRIKEGIALNPYDRSTFYLPKSPVGYIDQPFSKEFAALQGPQTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1Y9</accession>
    <name>Q2H1Y9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mannan endo-1,4-beta-mannosidase A</fullName>
            <ecNumber evidence="4">3.2.1.78</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Endo-beta-1,4-mannanase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_04207</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="4"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223421.1">
        <property type="nucleotide sequence ID" value="XM_001223420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1Y9"/>
    <dbReference type="SMR" id="Q2H1Y9"/>
    <dbReference type="STRING" id="306901.Q2H1Y9"/>
    <dbReference type="GeneID" id="4392345"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04207"/>
    <dbReference type="eggNOG" id="ENOG502QS4Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031603_4_1_1"/>
    <dbReference type="InParanoid" id="Q2H1Y9"/>
    <dbReference type="OMA" id="MNLGIDT"/>
    <dbReference type="OrthoDB" id="406631at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046355">
        <property type="term" value="P:mannan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000076">
        <property type="entry name" value="Mannan endo-1,4-beta-mannosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF39">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208846" description="Mannan endo-1,4-beta-mannosidase A" evidence="12">
        <location>
            <begin position="18"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="13">
        <location>
            <begin position="45"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ87588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="368" mass="40102" checksum="0E49088FD151F017" modified="2006-03-21" version="1">MKAIFTLGLSLLSAAQALPSARAAASSTVDGTRFSIDGKTGYFAGTNSYWIGFLTNNQDIDTTLDHIATSGLKILRVWGFNDVNTKPGAGTVWFQLLSSSGSQINTGTDGLQRLDYVVQSAEKRGVKLIINFVNFWDDYGGMNAYVKAFGGSKESWYTNANAQAQYKKYIEAVVSRYSKSDAVFAWELANEPRCKGCSTDVIYKWATDISAYIRSLDSSHMITLGDEGFGLPGDTTYPYQYTEGTDFVKNLGIKDLDFGTFHMYPDSWGVPYSFGEGWIKSHAAACKAAGKPCLLEEYGANASCDIQKPWQQSSLALAADGMSGDLFWQWGDQLSSGQTHNDGNTVYYGSELATCLVTDHVKAIEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2Q0</accession>
    <name>Q2H2Q0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_03946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223160.1">
        <property type="nucleotide sequence ID" value="XM_001223159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2Q0"/>
    <dbReference type="GeneID" id="4392805"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03946"/>
    <dbReference type="HOGENOM" id="CLU_669026_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2Q0"/>
    <dbReference type="OrthoDB" id="4586166at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ87327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="411" mass="44805" checksum="882C722B05D15DA6" modified="2006-03-21" version="1">MEQADKGAPKGGAQATEQILTFIGAVLLLYGDQLTLQFQSTIRGFRDYLLLAFGPVGVGLATLNTIRIAGPKWLKLSVGRYRPLVCSVVCPIVHEAVANQGVMNSRSREEPAVIEKELLPSTSAGVCEAWTGRNISRIKGSLPLGNITTLIVTEKGRILDLQRRLYLHTTPHHTGFHWKLQSNDDSEHRPGDFKFMVNGSSNLSWSLKKPSSPWLGFESRSILAVVGALVQSGAWVFISKLAAVDTQDGRNGVICYFVGAGLTFIALEPGALVDDAGESMDQSTCFRIHLTYPPEPVENNAVPTPTPAGGVNTVEYYGIRAMDTTLADQCLQELSLLFVEAIATRIQAVGGCPTKLSAERHGARAWEHTLLKDLAEQIKNNQINPDIEDTLALVVPVFMRHNILPKEGLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2R3</accession>
    <name>Q2H2R3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223147.1">
        <property type="nucleotide sequence ID" value="XM_001223146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2R3"/>
    <dbReference type="GeneID" id="4392661"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03933"/>
    <dbReference type="eggNOG" id="ENOG502S1IW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_429591_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2R3"/>
    <dbReference type="OMA" id="CHEIAGA"/>
    <dbReference type="OrthoDB" id="5562739at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR XBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="2">
        <location>
            <begin position="83"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="637" mass="69377" checksum="4994F0FDA164FDB6" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2R4</accession>
    <name>Q2H2R4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223146.1">
        <property type="nucleotide sequence ID" value="XM_001223145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2R4"/>
    <dbReference type="GeneID" id="4392870"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03932"/>
    <dbReference type="HOGENOM" id="CLU_2158087_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2R4"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="111" mass="12063" checksum="DC95F466D07969EA" modified="2006-03-21" version="1">MSRLWTSDREISRRVLSGGQVARQTAGSRTQRPPTRQKAAPHPKRSNSSVWTRRAFTAGPESTQAFRGLPFEDSPTTATVAATATVEGLDPHFTTVVLVGKLHYQIAGMAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2Z7</accession>
    <name>Q2H2Z7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="10">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_03849</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
            <location evidence="10">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="10"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223063.1">
        <property type="nucleotide sequence ID" value="XM_001223062.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2H2Z7">
        <property type="interactions" value="489"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H2Z7"/>
    <dbReference type="GeneID" id="4392266"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03849"/>
    <dbReference type="eggNOG" id="KOG1057">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000914_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H2Z7"/>
    <dbReference type="OMA" id="AQIWACS"/>
    <dbReference type="OrthoDB" id="18042at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052723">
        <property type="term" value="F:inositol hexakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000036">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VIP1 N-terminal" evidence="14">
        <location>
            <begin position="280"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp fold RimK-type" evidence="13">
        <location>
            <begin position="424"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1095"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1423"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="906"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="624"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="756"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1109"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1427"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="1461"/>
            <end position="1472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ87230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1472" mass="160801" checksum="B0F84AE44470D0E3" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H477</accession>
    <name>Q2H477_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_06538</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222633.1">
        <property type="nucleotide sequence ID" value="XM_001222632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H477"/>
    <dbReference type="GeneID" id="4390308"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06538"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_3_1_1"/>
    <dbReference type="InParanoid" id="Q2H477"/>
    <dbReference type="OMA" id="WMDEVLR"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF12">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="347"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ89919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="631" mass="70782" checksum="C8F48E877C0B8567" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H498</accession>
    <name>Q2H498_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_06517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222612.1">
        <property type="nucleotide sequence ID" value="XM_001222611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H498"/>
    <dbReference type="GeneID" id="4390859"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06517"/>
    <dbReference type="HOGENOM" id="CLU_3351018_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H498"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="37" mass="3890" checksum="A69368F59750AB8E" modified="2006-03-21" version="1">MPGVATELVTAGFPAEHEANVLLNSPSRCFRKDSASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4D8</accession>
    <name>Q2H4D8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="23">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">CHGG_06477</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 23">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38583"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:38584"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66036"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:66037"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="23">Membrane</location>
            <topology evidence="23">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="23"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222572.1">
        <property type="nucleotide sequence ID" value="XM_001222571.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2H4D8">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H4D8"/>
    <dbReference type="GeneID" id="4391425"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06477"/>
    <dbReference type="eggNOG" id="KOG0206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000846_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4D8"/>
    <dbReference type="OMA" id="QALRCGR"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070867">
        <property type="term" value="C:mating projection tip membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990531">
        <property type="term" value="C:phospholipid-translocating ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140351">
        <property type="term" value="F:glycosylceramide flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090554">
        <property type="term" value="F:phosphatidylcholine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140346">
        <property type="term" value="F:phosphatidylserine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <source>
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    <sequence length="1509" mass="169225" checksum="D5A6BDE3F6249DE8" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
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            <begin position="1"/>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="189" mass="20872" checksum="8DA439E3F83EACBF" modified="2006-03-21" version="1">MYNDQGNYKGWTNQTTTDLDPLKSIGYLPPPSRSGSPHGTRRVELVPPNVNCEAEGIPVEELSSLVYLSGLSSGESPWFLGFFHSIVRGPRSDPEFASRRRNIGNLNEYGLALKSTLQPNLMCENSLNVGVWSACYSRASLVFGGKWTIGLSGGLALTMRDVATFLRARLKAASLTRDLKQMVRRFRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5C5</accession>
    <name>Q2H5C5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_06140</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLT11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222235.1">
        <property type="nucleotide sequence ID" value="XM_001222234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5C5"/>
    <dbReference type="STRING" id="306901.Q2H5C5"/>
    <dbReference type="GeneID" id="4391114"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06140"/>
    <dbReference type="eggNOG" id="KOG0153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027112_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H5C5"/>
    <dbReference type="OMA" id="CPLRVQW"/>
    <dbReference type="OrthoDB" id="10259600at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12265">
        <property type="entry name" value="RRM_SLT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000396">
        <property type="entry name" value="Putative Pre-mRNA-splicing factor slt11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034356">
        <property type="entry name" value="Slt11_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="217"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="151"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="308"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ89521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="364" mass="39789" checksum="33A4E1580AAEFC7C" modified="2006-03-21" version="1">MPPQIKQDLNRSGWETTDFPSVCENCLPENPYVKMLKEDYGAECKLCTRPFTIFSWSGDGRAQGRKRRTNICLTCARLKNACQCCIMDLQFGLPIVIRDKALELIAPGPQSEINREYFAQNNEKAIEEGRAGVEEYEKADEKARELLRRLAQSKSRDGRESGGSARGWVVPGPIRTRDSRAAARAGAKAGPRKGPLGANAPPPGPRDWMPPNDRNIMSLFVTGIEDDLPEYKIRDFFKVFGKIKSLVVSHMTHCAFVNYETRDGAEKAAAECKGRAVIAGCPLRVRWSVPKAIGTMDKEERTEMLRDGRSAFPQTNRRGPQKAIEGGAAQSGSSTAADGDDPSGLVVAAPPGAADVQYASLSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5F4</accession>
    <name>Q2H5F4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222206.1">
        <property type="nucleotide sequence ID" value="XM_001222205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5F4"/>
    <dbReference type="GeneID" id="4390706"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06111"/>
    <dbReference type="eggNOG" id="ENOG502T5YG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_860527_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5F4"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="323" mass="35998" checksum="80B7ACCD5AC67989" modified="2006-03-21" version="1">MAPITEDKTVTQILTGPSTWVSWHREFTNTMDALKLLEYFQGTKELLTEPRSSVNPLRIMERAQERRKKIAEEKGVAILALTDEELEGATEATLDISTATTPPDSETEGEQASGAPTAAQKRTAGKAVDDYFQTYGLFILSIHSEPSRQPPSLRSPMKDPGSKTTLEPWDRSCHYMQHWYGPTASPNPNLGYREIATEARQTTIPLLPSTTGARIQKGAFPSFNPGDSNESGKASKASHKRKNSTLPTEKAKCRLCHGRHHMERCAYIMPHLAPEGFQIRDHVRERVDQKIASDSSLKAEVERIQNKRTKNSKQQPDAPAQGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5I9</accession>
    <name>Q2H5I9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1275 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222171.1">
        <property type="nucleotide sequence ID" value="XM_001222170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5I9"/>
    <dbReference type="STRING" id="306901.Q2H5I9"/>
    <dbReference type="GeneID" id="4391279"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06076"/>
    <dbReference type="eggNOG" id="ENOG502RR78">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061825_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5I9"/>
    <dbReference type="OMA" id="EDDRWIK"/>
    <dbReference type="OrthoDB" id="5288586at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF1">
        <property type="entry name" value="DUF1275 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="28718" checksum="8E6C7A22CC97ACED" modified="2006-03-21" version="1">MTRNGPLSEHTPLLSPSVPKPQQIWARWHQHLAAKVSRSWADCILILCYLITGLLDSASISVWGSFVSMQTGNTVYLGLGLAAPSASTRWIKSAVSISAFCVGSFLFSRFHRRFTPTRRWVLAVSFTAQACLTSVAAGLVTSAGPPPDPENLGWPVLVPIALVAFQSCGQAVVSRALDYNALTSVVLTSVYCDLFSDARLFKLGNVQRNRRSAAPLFLLVGAFLGGHFADSSWGVAGALWAASILKFALVVVWLVWPAESLRVEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5L5</accession>
    <name>Q2H5L5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_06050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222145.1">
        <property type="nucleotide sequence ID" value="XM_001222144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5L5"/>
    <dbReference type="GeneID" id="4390287"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06050"/>
    <dbReference type="eggNOG" id="ENOG502RX64">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_595800_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5L5"/>
    <dbReference type="OMA" id="TISSTWH"/>
    <dbReference type="OrthoDB" id="4330117at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="352"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="49574" checksum="D46FC72AEC95E708" modified="2006-03-21" version="1">MDIMDSPPRAQCLDPVLPPMPRRQSCDRCHEQKVRCVTEGANGAMALGGITEEGDSNPDGHVVAPIPCGRCRKAGTVCVYSRNVGLGTFDHSQESTHEPIPPRTVSSPVAASPACEQFTHHHNLGLDTPPPTEDWQTPSYRCDSTQPLTNMCPSSSFPAVPDVAYAPLFQDPAANLVPAAEDIVGGYSWGFPASSDYFLEDLAQINLRIHLAGRALPSPAGSPPPWTWPAANDSFDAACSLIDAVDRFAARRPIPAFPEPSSNPQTNSGTINAALDSSACLMVHASHQALLGVFEHLSTALLLHLSAEQHQHTPPRTPPDAAFLPPGNTQALIMTNLISHLLNQLDRAFLSLSTSTPSHPHPQHHHHNHNHNHNHNHHQPPHQHPGHKPNPNILRSMAIPTGLPPPETDTTISSTWHGSGAPADTLFNEMALRQRKVRGQVKAVERLLGRDSAGRGHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H615</accession>
    <name>Q2H615_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7905 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221995.1">
        <property type="nucleotide sequence ID" value="XM_001221994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H615"/>
    <dbReference type="GeneID" id="4390155"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05900"/>
    <dbReference type="eggNOG" id="ENOG502RQNC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_535269_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H615"/>
    <dbReference type="OMA" id="NVFHREK"/>
    <dbReference type="OrthoDB" id="4739136at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057227">
        <property type="entry name" value="DUF7905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25482">
        <property type="entry name" value="DUF7905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7905" evidence="2">
        <location>
            <begin position="247"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="580" mass="63076" checksum="9E13D442ACA18A51" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H645</accession>
    <name>Q2H645_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA+ ATPase lid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221965.1">
        <property type="nucleotide sequence ID" value="XM_001221964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H645"/>
    <dbReference type="STRING" id="306901.Q2H645"/>
    <dbReference type="GeneID" id="4391025"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05870"/>
    <dbReference type="eggNOG" id="KOG0742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_444800_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H645"/>
    <dbReference type="OrthoDB" id="4590793at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase lid" evidence="1">
        <location>
            <begin position="489"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="614" mass="69115" checksum="84A36DED58E9040D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H646</accession>
    <name>Q2H646_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221964.1">
        <property type="nucleotide sequence ID" value="XM_001221963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H646"/>
    <dbReference type="GeneID" id="4391024"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05869"/>
    <dbReference type="HOGENOM" id="CLU_1786620_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H646"/>
    <dbReference type="OrthoDB" id="5193300at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209001" description="Cyanovirin-N domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="15440" checksum="D5DFEFF3E5B57FEF" modified="2006-03-21" version="1">MLSFSTLTLAMLLLTLSNGTRAQGDEDDPTPATPHWITPAVTLPSPYGHPSLYVTQNGAGECLASLQVYYTRTCRVQTTVWDGTTTSRVSVDCQGCTRLASSILVGHCPLGVHYTPYPDTTMSRPWTSFSFVCAPTPTPAGAGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H678</accession>
    <name>Q2H678_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_05837</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221932.1">
        <property type="nucleotide sequence ID" value="XM_001221931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H678"/>
    <dbReference type="STRING" id="306901.Q2H678"/>
    <dbReference type="GeneID" id="4390032"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05837"/>
    <dbReference type="eggNOG" id="ENOG502SS3N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042086_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H678"/>
    <dbReference type="OMA" id="MTFFNFQ"/>
    <dbReference type="OrthoDB" id="2830640at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="342"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="342"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ89218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="440" mass="51439" checksum="B1927AF27DF7F9E6" modified="2006-03-21" version="1">MDDYMFRSYVTEFKCVQEETSYLEIFNYSDPSFNTSEEHRFRFDELPDEFGNFLHRRAYEEMVRTLHLPFRAIEGTSAVGPFFWAAFDQDDEDPHLQIIFRKSDVRKKGKTRGWELMLSHSFRTHITSGFAKGTASSDMVESIKHLRACAAQILHPLLLPTIILSHDLSMKNDQKQRNARQWLRDLETAVSMRSEVLEEENKYIRGTMIDLDQINMDLVECHSQVLWKRPQAYQEIIRGVCQAMDRFWEKARDDEAYGGQAEGDRELRTHYARAADDSAGGKSKLGLTMAGEQRRLAHASKRDSTSMKILSLLGAIFLPATYLASIFGMTFFNFVPRRRQRPPLTSHHHRYRHHPPPQTPQPPHRGTPSPPYYGFISPSPSPVTLIIVVCWRWWNRRREAQYAKEDRDVEERIEKMEAQIMATMRKRTMSKMRTWEVGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6K8</accession>
    <name>Q2H6K8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Asparaginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_05707</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221802.1">
        <property type="nucleotide sequence ID" value="XM_001221801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6K8"/>
    <dbReference type="FunCoup" id="Q2H6K8">
        <property type="interactions" value="1061"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H6K8"/>
    <dbReference type="GeneID" id="4390559"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05707"/>
    <dbReference type="eggNOG" id="KOG0555">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_10_1"/>
    <dbReference type="InParanoid" id="Q2H6K8"/>
    <dbReference type="OMA" id="HEDAIRY"/>
    <dbReference type="OrthoDB" id="1931232at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF16">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class II (D/K/N)" evidence="12">
        <location>
            <begin position="2"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ89088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="265" mass="31248" checksum="B9BFE4669C3F955D" modified="2006-03-21" version="1">MVQTQVEGGSTLFKYDYYGEEAYLTQSSQLYLETVMQSLGNVYCIEKSFRAEKSLTRRHLSEYTHVEAELDFIEFNDLLDHLEEMISRVVDKVLADETMRGYVETLNPGFQKPTRPYMRMKYEEAIEWLNKQDPPILNEDGNPHVFGDDIAEAAERRMTDIINRPIFLTHFPVEIKAFYMKKDPQDLRVTESVDVLSMFFLFSFFFFYPKRWCIHGKILTLQPVPGVGEIVGGSMRMDNYDELIEAYKKNGIPHEPYYWYTDQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7C5</accession>
    <name>Q2H7C5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_05440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221535.1">
        <property type="nucleotide sequence ID" value="XM_001221534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7C5"/>
    <dbReference type="GeneID" id="4390295"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05440"/>
    <dbReference type="HOGENOM" id="CLU_2263443_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7C5"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ88821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="103" mass="10824" checksum="97F9BBA4924EBEA9" modified="2006-03-21" version="1">MCSKDFVDSCLIVLCLPLKGWKKFQYGAGICYNRSGYTWPSSVEVNVTTPTAINIRSSTASSGINISSSTASSSINIKAAIPSPSVVNTSAIAFSVNIHSTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7J1</accession>
    <name>Q2H7J1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221469.1">
        <property type="nucleotide sequence ID" value="XM_001221468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7J1"/>
    <dbReference type="GeneID" id="4390060"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05374"/>
    <dbReference type="HOGENOM" id="CLU_2014991_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7J1"/>
    <dbReference type="OrthoDB" id="10439175at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="123" mass="13529" checksum="11519301F50034D4" modified="2006-03-21" version="1">MGAGNGPIRGSGAEEQLGDRLSWCSSPRQTGRRRLQDDLRTGRGNRSVVGIFFACVRPNSETDQAECAGWPASAVHCSLQQRLAAASIAQAEAEPAASSSQMDHRWTRAKSQRWMQAHMHHTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7X5</accession>
    <name>Q2H7X5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230195.1">
        <property type="nucleotide sequence ID" value="XM_001230194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7X5"/>
    <dbReference type="STRING" id="306901.Q2H7X5"/>
    <dbReference type="GeneID" id="4388749"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03679"/>
    <dbReference type="eggNOG" id="ENOG502RHGF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033245_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7X5"/>
    <dbReference type="OMA" id="QIMDNHP"/>
    <dbReference type="OrthoDB" id="3883941at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="374"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="411" mass="44793" checksum="631F3E9ECD1F40A6" modified="2006-03-21" version="1">MFTARLPSRVAPIARNARALRVRQPQRRFQSSQAGAAGSSHFVSGVAGGVAGAGLLYGIYLLTPTGKMARKINAAARETDRKYQEAAATIRDKTPTTDEAVSKLKQFCYSYVAWVPGGRQYVDTAFNDLAAIRQSHGKEVDQIVNETYREFQGITSTGLSLESASKAYDAITNLAKKIANLSGSAADQILERHPQLNDKVGGSIKQLKNMGAQYGPEAKKLVDQTWTQVNDIMKNGFSAENEDKVRKIVEERTQQIRKIGDDLWDKGLEQAKPYLDKSPRLKELVTGNQDLLKKENVTGLFQQIKSLGEGGDMGKLEEYVKETVDKAKAKGSEATGEGTGFAALSQLLGSASDDAGRKLQDNIGLLSEVASKHASEGKELVEETKNDLRKLLEEKAKKAQKIADSAKKDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H860</accession>
    <name>Q2H860_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_03594</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230110.1">
        <property type="nucleotide sequence ID" value="XM_001230109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H860"/>
    <dbReference type="GeneID" id="4389627"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03594"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H860"/>
    <dbReference type="OMA" id="WIGSIQC"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ91659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="59698" checksum="064E422964844709" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8N5</accession>
    <name>Q2H8N5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Small nuclear ribonucleoprotein Sm D2</fullName>
            <shortName evidence="12">Sm-D2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 12">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_03419</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229935.1">
        <property type="nucleotide sequence ID" value="XM_001229934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8N5"/>
    <dbReference type="FunCoup" id="Q2H8N5">
        <property type="interactions" value="1034"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H8N5"/>
    <dbReference type="GeneID" id="4389672"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03419"/>
    <dbReference type="eggNOG" id="KOG3459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_2_1_1"/>
    <dbReference type="InParanoid" id="Q2H8N5"/>
    <dbReference type="OMA" id="DVKEMWT"/>
    <dbReference type="OrthoDB" id="437526at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000018">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="14">
        <location>
            <begin position="35"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ91484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="103" mass="11963" checksum="9E32D5A4B991C8D0" modified="2006-03-21" version="1">MSDVNIQALLQKPRNECTEYEIAQLENWEMSNGPLSLLQTAVRSHSQVLISIRSNRKLLARVKAFDRHCNMILENVKEMWTETPVHNGKKGRPVNKDRFISKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8Y7</accession>
    <name>Q2H8Y7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229833.1">
        <property type="nucleotide sequence ID" value="XM_001229832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8Y7"/>
    <dbReference type="GeneID" id="4389859"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03317"/>
    <dbReference type="HOGENOM" id="CLU_3319986_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8Y7"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="39" mass="4324" checksum="0D151B89B51B0548" modified="2006-03-21" version="1">MYLGAKSQDGVRHPTRELPRESSFWKSLTTGTCELLNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H938</accession>
    <name>Q2H938_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_03266</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34935"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229782.1">
        <property type="nucleotide sequence ID" value="XM_001229781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H938"/>
    <dbReference type="FunCoup" id="Q2H938">
        <property type="interactions" value="1001"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H938"/>
    <dbReference type="GeneID" id="4389306"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03266"/>
    <dbReference type="eggNOG" id="KOG2298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015515_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H938"/>
    <dbReference type="OMA" id="MEMQYFV"/>
    <dbReference type="OrthoDB" id="57698at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00858">
        <property type="entry name" value="GlyRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.200:FF:000001">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="215"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="122"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAQ91331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="677" mass="76155" checksum="3E3DC27D113F3E15" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H952</accession>
    <name>Q2H952_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229768.1">
        <property type="nucleotide sequence ID" value="XM_001229767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H952"/>
    <dbReference type="STRING" id="306901.Q2H952"/>
    <dbReference type="GeneID" id="4388714"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03252"/>
    <dbReference type="eggNOG" id="ENOG502S4QH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067876_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H952"/>
    <dbReference type="OMA" id="WQPKAWD"/>
    <dbReference type="OrthoDB" id="10255576at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="259" mass="28933" checksum="A52635747E3E7305" modified="2006-03-21" version="1">MSQPPITTALRVWYKWKALRLPWRRRFLVGLDLNGNTYWEFLDRGVPIPPRDRNPNPHNPPPSTSTPSSPNTPPIRWRRMVVCPPGTHQGSVNPPPAWHQWLRHTRADPPSLAEQRGEVARQARMRVLAAEADARWEAKPRVAGDGVADGIQQQKEGRLMGVRVPPLDTERRVGPGSKVLAEEGKQHGGGKLGDDEVVERREETWKRMRQEAGSEGGGEGGKKSTAEKVKGPDPWKQARGGPSEQWQPKGWEPAAKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9V0</accession>
    <name>Q2H9V0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229520.1">
        <property type="nucleotide sequence ID" value="XM_001229519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9V0"/>
    <dbReference type="GeneID" id="4388676"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03004"/>
    <dbReference type="eggNOG" id="ENOG502S27H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_307210_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9V0"/>
    <dbReference type="OrthoDB" id="4159838at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="814" mass="87386" checksum="3858961AF4D8BF61" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9X0</accession>
    <name>Q2H9X0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">EXPERA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_02984</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229500.1">
        <property type="nucleotide sequence ID" value="XM_001229499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9X0"/>
    <dbReference type="STRING" id="306901.Q2H9X0"/>
    <dbReference type="GeneID" id="4388944"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02984"/>
    <dbReference type="eggNOG" id="KOG4826">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072128_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9X0"/>
    <dbReference type="OMA" id="VIEGWFC"/>
    <dbReference type="OrthoDB" id="58557at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000247">
        <property type="term" value="F:C-8 sterol isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047750">
        <property type="term" value="F:cholestenol delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004769">
        <property type="term" value="F:steroid Delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF0">
        <property type="entry name" value="3-BETA-HYDROXYSTEROID-DELTA(8),DELTA(7)-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="7" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="15">
        <location>
            <begin position="63"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAQ91049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="237" mass="26264" checksum="C90E0C786B75BA45" modified="2006-03-21" version="1">MQDHAGSSPQGHPYFPQDAIIPGYAPNSTPLLGILAAFGGIIGVFVLGCVALATWYSPALKRADQLTVAWFALCGFLHLFFEGYFVLNHATIASSQSLFAQLWKEYALSDSRYLTSDPFMLCIESLTVLTWAPLSLLTALLTARNNPREQGARHLLQTVVCVGHLYGVALYYGTCGFAEHMRGLSYSRPEVMYYWVYYAGMNAPWAVVPGLLLWRSWGAVQAAFGDVARREEGRKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAB4</accession>
    <name>Q2HAB4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_02840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229356.1">
        <property type="nucleotide sequence ID" value="XM_001229355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAB4"/>
    <dbReference type="FunCoup" id="Q2HAB4">
        <property type="interactions" value="216"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HAB4"/>
    <dbReference type="GeneID" id="4388870"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02840"/>
    <dbReference type="eggNOG" id="KOG1994">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046724_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HAB4"/>
    <dbReference type="OMA" id="LEPCHSA"/>
    <dbReference type="OrthoDB" id="786951at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039249">
        <property type="entry name" value="GPATCH11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF0">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="107"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ90905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="467" mass="51825" checksum="4447E483C9B52089" modified="2006-03-21" version="1">MNSLNPPRKNNPPPNPPSNEQSPEEEEEEEEDYMSMTFTTTPSTTTHTHPHLNRQPHAPAETSLQRRQRLRREAEARAHPKSKAELAAEADARREAALAQSLFEAKPQSKGLAMMARMGFRGGGLGRRVDGGAGEGGEGGGGAGGGGRTEPIRIEMRDGREGIGLESERKRKVREAAETAGERAKRAKAEEGEYRERLRREREEARWERQLAAAQKVAERMAAEREEEEAQAEGRKVVVRPLKGIPVVWRGLVRSREEAERDRRMRYDLEQGLARLPTYDDAEEDEADKKALGKAATTYATAEDLDEEDPELEEFNALPVDERLQKAVGHLREEYRYCFWCKFAYPDEEMEGCPGLTIPCSSLTLLATSLQLVCQELFPIFRKTSHPPPSVLPIPPTVQMLAKRGRLPLPLPHAFPSSHPPSPPPTSSPSHPPPYPPPPNPPTSPSPPPPRSPNSDPVPAQNRASTP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAN0</accession>
    <name>LSM6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>U6 snRNA-associated Sm-like protein LSm6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">LSM6</name>
        <name type="ORF">CHGG_02724</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAQ90789" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90789.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229240.1">
        <property type="nucleotide sequence ID" value="XM_001229239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAN0"/>
    <dbReference type="SMR" id="Q2HAN0"/>
    <dbReference type="FunCoup" id="Q2HAN0">
        <property type="interactions" value="695"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HAN0"/>
    <dbReference type="GeneID" id="4389415"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02724"/>
    <dbReference type="eggNOG" id="KOG1783">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_7_4_1"/>
    <dbReference type="InParanoid" id="Q2HAN0"/>
    <dbReference type="OrthoDB" id="268799at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01726">
        <property type="entry name" value="LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000037">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF1">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0508">mRNA splicing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0747">Spliceosome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000333592" description="U6 snRNA-associated Sm-like protein LSm6">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Sm" evidence="2">
        <location>
            <begin position="13"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="82" mass="8823" checksum="EF30E4A9EEF6BCE6" modified="2008-05-20" version="2">MENGAATQGEGKDPSGFLSEIIGNPVTVKLNSGVVYKGELQSVDGYMNIALEKTEEYVNGAKRRSYGDAFVRGNNVMYISAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HB60</accession>
    <name>Q2HB60_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229060.1">
        <property type="nucleotide sequence ID" value="XM_001229059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HB60"/>
    <dbReference type="STRING" id="306901.Q2HB60"/>
    <dbReference type="GeneID" id="4388740"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02544"/>
    <dbReference type="eggNOG" id="KOG0028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061288_5_0_1"/>
    <dbReference type="InParanoid" id="Q2HB60"/>
    <dbReference type="OMA" id="DIAFEPM"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="17964" checksum="25B2F32B196FCF41" modified="2006-03-21" version="1">MPPRRRAPPTTSTPKPTPKSNTPRPSKLAKEHNLTALEESEIHEAFSLFAEPLDGEPQGVMPISDVRRALIALGIPPSSPAQLADLTAALDPDEEGFATYEAFVGVCALQMQVRRFEEEEEGGEGHRAELDEAYGLFTGRGGDGEGGEAEVITLGDLRRVAAVVEVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBF4</accession>
    <name>Q2HBF4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Anaphase-promoting complex subunit cut9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_02450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228966.1">
        <property type="nucleotide sequence ID" value="XM_001228965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBF4"/>
    <dbReference type="FunCoup" id="Q2HBF4">
        <property type="interactions" value="1013"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HBF4"/>
    <dbReference type="GeneID" id="4388965"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02450"/>
    <dbReference type="eggNOG" id="KOG1173">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011751_4_1_1"/>
    <dbReference type="InParanoid" id="Q2HBF4"/>
    <dbReference type="OMA" id="DPFHNNA"/>
    <dbReference type="OrthoDB" id="10006270at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF9">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="575"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="625"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ90515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="672" mass="74170" checksum="636B4D585A2AB4C9" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBG3</accession>
    <name>Q2HBG3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS13m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_02441</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228957.1">
        <property type="nucleotide sequence ID" value="XM_001228956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBG3"/>
    <dbReference type="FunCoup" id="Q2HBG3">
        <property type="interactions" value="293"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HBG3"/>
    <dbReference type="GeneID" id="4389237"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02441"/>
    <dbReference type="eggNOG" id="KOG3311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103849_2_4_1"/>
    <dbReference type="InParanoid" id="Q2HBG3"/>
    <dbReference type="OMA" id="MNVKRLM"/>
    <dbReference type="OrthoDB" id="525520at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.910.10:FF:000004">
        <property type="entry name" value="Small subunit ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ90506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="115" mass="13111" checksum="1389AB467B4ED068" modified="2006-03-21" version="1">MVFIFGVNFNEQKLVKSFYALGPQTADRILAKYSIYPGAKMGTLPPKTLTALTAELSTMNIESDARRVLQDNIKRLRDMGTYRGRRHAMGLPVRGQRTRNQIETARKLNKVERRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCT0</accession>
    <name>Q2HCT0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_01974</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221195.1">
        <property type="nucleotide sequence ID" value="XM_001221194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCT0"/>
    <dbReference type="ESTHER" id="chagb-q2hct0">
        <property type="family name" value="Lipase_3"/>
    </dbReference>
    <dbReference type="GeneID" id="4386411"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01974"/>
    <dbReference type="eggNOG" id="ENOG502RX5M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_324388_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCT0"/>
    <dbReference type="OrthoDB" id="160645at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054293">
        <property type="entry name" value="DUF7029"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055647">
        <property type="entry name" value="DUF7223"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22974">
        <property type="entry name" value="DUF7029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23865">
        <property type="entry name" value="DUF7223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208781" evidence="1">
        <location>
            <begin position="26"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7029" evidence="3">
        <location>
            <begin position="98"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7223" evidence="4">
        <location>
            <begin position="267"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="2">
        <location>
            <begin position="628"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ93739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="890" mass="95746" checksum="DE50EEACF72E6A3F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDE3</accession>
    <name>Q2HDE3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ArsA/GET3 Anion-transporting ATPase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_01761</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arsA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220982.1">
        <property type="nucleotide sequence ID" value="XM_001220981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDE3"/>
    <dbReference type="STRING" id="306901.Q2HDE3"/>
    <dbReference type="GeneID" id="4386898"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01761"/>
    <dbReference type="eggNOG" id="KOG2825">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_665645_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HDE3"/>
    <dbReference type="OrthoDB" id="17948at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="4">
        <location>
            <begin position="227"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="342"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ93526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="413" mass="44471" checksum="C5C0F75A1302FBE9" modified="2006-03-21" version="1">MVPFWRPSLDRFEDRKLSQNTANHHPHEPSSSTSPPLFSFDDIGGLVPPSHEEITDLALVQDLERGARREATDGDQGANALITLNADHNERSNVAIIIFAIERALNALLRALFILAGNLERLIRDLLRCYDCMLAPVRYATNLIFPLCTACDTTSPLNNALRPQPRLGARLPATDLERTLQFAKSLGYNDVSLNHICTGCIPTSSTPITNQIMEPTLQSILDQRSLRWIFVGGKGGVGKTTTSCSLAIQLAKVRRSVLLISTDPAHNLSDAFSQKRVVVSSEARGVLGLRGPADVVNLMAVWGLSPEKGFAALGEGARAVVVNEGIKRRGFRGVVDIVKPAEGGEEVRKGDGDGEGEGEGGNGVKGGKKQKQQQQQGQQGQKRKNGGGGGGQTGEMSKRQAKKMKKEASQAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDP3</accession>
    <name>Q2HDP3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_01661</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220882.1">
        <property type="nucleotide sequence ID" value="XM_001220881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDP3"/>
    <dbReference type="STRING" id="306901.Q2HDP3"/>
    <dbReference type="GeneID" id="4387802"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01661"/>
    <dbReference type="eggNOG" id="KOG0379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019536_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HDP3"/>
    <dbReference type="OMA" id="TMTWDRR"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF3">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ93426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="52471" checksum="4677BF10B6880C63" modified="2006-03-21" version="1">MADQARADGHEGLPQPPQNIKIARRPHPAPALAIVRGSNHTRLVGRDNAVALPLGGLLLRSLHKAANTHYKSATSHCRKRRCRQQQGGPASDSLSAALHVGSSQAGPGACGESAAGNGAAPGAVSRVGTGRGAPAKGAETYTAFPVLADPKTAVDVPAAPASGMYWSRCATSGSPHTALRAHTATPVGSNVFVFGGCDARACFNELYVLDADAFYWSAPHVVGDVPVPLRAMTATAVGKKLVVFGGGDGPAYYNDVYVLDTVNLRWSRPRILGDKVPSKRRAHTACLYKNGIYVFGGGDGVRALNDIWRLDVSDMNKMSWKLISGPSSADGRSPITGKDLRPKARGYHTANMVGSKLIIYGGSDGGECFNDVWVYDVDIHTWRSVNVPVTHRRLSHTATIVGSYLFVIGGHDGNEYSNDVLLLNLVTMTWDRRKVYGLPPSGRGYHGTVLYDSRLLMIGGFDGSEVFGDVWSLELAVHAYYSQISHFKIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDQ3</accession>
    <name>Q2HDQ3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220872.1">
        <property type="nucleotide sequence ID" value="XM_001220871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDQ3"/>
    <dbReference type="GeneID" id="4387771"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01651"/>
    <dbReference type="eggNOG" id="ENOG502S04M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035511_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HDQ3"/>
    <dbReference type="OMA" id="HEMLPCP"/>
    <dbReference type="OrthoDB" id="2392789at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046921">
        <property type="term" value="F:alpha-(1-&gt;6)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132">
        <property type="entry name" value="ALPHA- 1,6 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132:SF29">
        <property type="entry name" value="ALPHA-(1,6)-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="624" mass="68491" checksum="352D1406E3E0A422" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDY6</accession>
    <name>Q2HDY6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-processing factor 39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_01568</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PRP39 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220789.1">
        <property type="nucleotide sequence ID" value="XM_001220788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDY6"/>
    <dbReference type="FunCoup" id="Q2HDY6">
        <property type="interactions" value="278"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HDY6"/>
    <dbReference type="GeneID" id="4387512"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01568"/>
    <dbReference type="eggNOG" id="KOG1258">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007434_3_1_1"/>
    <dbReference type="InParanoid" id="Q2HDY6"/>
    <dbReference type="OMA" id="IISWANL"/>
    <dbReference type="OrthoDB" id="10265668at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140727">
        <property type="term" value="P:siRNA-mediated pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000451">
        <property type="entry name" value="mRNA splicing protein (Prp39), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204">
        <property type="entry name" value="PRE-MRNA PROCESSING PROTEIN PRP39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204:SF5">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ93333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="572" mass="66892" checksum="38169B9DB763A3CA" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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                <person name="Birren B.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the NFYB/HAP3 subunit family.</text>
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    <dbReference type="STRING" id="306901.Q2HE25"/>
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    <dbReference type="OrthoDB" id="386949at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR003956">
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    </dbReference>
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        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
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    </dbReference>
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        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00685">
        <property type="entry name" value="NFYB_HAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="6">
        <location>
            <begin position="47"/>
            <end position="112"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
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        <location>
            <begin position="133"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ93294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="197" mass="21275" checksum="64BB068821C35CE5" modified="2006-03-21" version="1">MSDSPQSNPKDVEQGAPSGDEEAQMNDPQDPHSTGLGYEFEVKEQDRWLPIANVARIMKTALPENAKIAKEAKECMQECVSEFISFITSEASEKCQQEKRKTVNGEDILFAMSSLGFENYAEALKIYLSKYREQQSQSNRGENQPNRPSSQGYGAAGGSNPAGGFGAGLPGQQEGGDPQAYNLYGAQPGHNGAGADY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEH6</accession>
    <name>Q2HEH6_CHAGB</name>
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        <recommendedName>
            <fullName evidence="8">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_01378</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MEF2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EAQ93143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_001220598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEH6"/>
    <dbReference type="STRING" id="306901.Q2HEH6"/>
    <dbReference type="GeneID" id="4387010"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01378"/>
    <dbReference type="eggNOG" id="KOG0014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024080_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HEH6"/>
    <dbReference type="OMA" id="LGRYQYF"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:protein dimerization activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
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        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
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        <property type="entry name" value="MADS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945:SF534">
        <property type="entry name" value="MYOCYTE-SPECIFIC ENHANCER FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="534"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="390"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ93143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="564" mass="61411" checksum="C2205753D1333222" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HES9</accession>
    <name>Q2HES9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220496.1">
        <property type="nucleotide sequence ID" value="XM_001220495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HES9"/>
    <dbReference type="GeneID" id="4386536"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01275"/>
    <dbReference type="eggNOG" id="ENOG502RKIX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1360268_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HES9"/>
    <dbReference type="OrthoDB" id="10344581at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="201" mass="23481" checksum="F94125B817CB503D" modified="2006-03-21" version="1">MASAPTFSYPQTVKYRCHIVEYGIVVRKYGWSDHQRSRKVMKLDELCPKCERKLERRMLRNLHWLNDRNDFTIKYVYLYRDGESPMSSPEWPLYTESESGSTDEHRSPPWAMWAALKDDGKEAGDEVDDDDKNDDEKKEEAEEQSPEQKLLSVKHVAAVTTRLMKLLTVIESRNSLLLARELRYHPTGIENRSDMDGTVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HF07</accession>
    <name>Q2HF07_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220418.1">
        <property type="nucleotide sequence ID" value="XM_001220417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HF07"/>
    <dbReference type="STRING" id="306901.Q2HF07"/>
    <dbReference type="GeneID" id="4386533"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01197"/>
    <dbReference type="eggNOG" id="ENOG502STPC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167691_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HF07"/>
    <dbReference type="OMA" id="DAGQWKK"/>
    <dbReference type="OrthoDB" id="2565331at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40636">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40636:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="100" mass="9368" checksum="0C2635BC311E939E" modified="2006-03-21" version="1">MNTTNNKTNTNTGLTGAGKTVTSTLGNTVGGLANTVGGVLGAASRGVGETVNGATGGVGRPLGDGIANIGSGVEGGVANVAQGVKDAGEWKTGAGSGVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFB2</accession>
    <name>Q2HFB2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-ubiquinone oxidoreductase 49 kDa subunit, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_01092</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220313.1">
        <property type="nucleotide sequence ID" value="XM_001220312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFB2"/>
    <dbReference type="STRING" id="306901.Q2HFB2"/>
    <dbReference type="GeneID" id="4386598"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01092"/>
    <dbReference type="eggNOG" id="KOG2870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HFB2"/>
    <dbReference type="OMA" id="TRMDYLT"/>
    <dbReference type="OrthoDB" id="1009at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.645.10:FF:000005">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004739">
        <property type="entry name" value="PRK06075.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="6">
        <location>
            <begin position="215"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ92857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="485" mass="54425" checksum="2D868EFB405B0FE8" modified="2006-03-21" version="1">MSATLYRLAGRSAKRLCIRSRATPSTAFASSISHPARAFSVSAFRRYAEPQEHQGTRLVPTGPDFTTPADPYDLEAQLSSGGTSTTVKSRDESVEDRKVRHYTVNFGPQHPAAHGVLRLILELNGEEIIRSDPHVGLLHRGTEKLCEYKTYLQALPYFDRLDYVSMMTNEQCFSLAVEKLLNIEIPDRAKFIRTLFGELTRVLNHLMAVLTHAMDVGALTPFLWGFEEREKLMEFYERVSGARLHAAYVRPGGVHQDIPVGLLDDIYQWATQFGDRIDETEEMLTDNRIWINRLQGVGVVSAADALNLSFTGVMLRGSGVPWDIRKSQPYDAYDQVEFDVPVGTNGDCYDRYLCRMEEFRQSLRIIIQCLNKMPAGPVRVEDYKISPPPRSAMKENMEALIHHFLLYTKGYAVPPGDTYSAIEAPKGEMGVYVVSDGSERPYRVSIRAPGFAHLSGFDHVSRGHLLADAVAVIGTMDLVFGEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFK0</accession>
    <name>Q2HFK0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220225.1">
        <property type="nucleotide sequence ID" value="XM_001220224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFK0"/>
    <dbReference type="GeneID" id="4387455"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01004"/>
    <dbReference type="HOGENOM" id="CLU_1981398_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HFK0"/>
    <dbReference type="OrthoDB" id="4586880at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="126" mass="13890" checksum="F91EED4518F9647B" modified="2006-03-21" version="1">MATTTPPPRPFVKGPLQVPRPAPVAASYTQATRMRSETEVWQPGSNKVLQVSSQHPNLHSTAGHQPQQRSARDSFAHSPRQAVPQTRQGTNAEFPSASPNLHTLTEPRIHPHGTSQTRVRQQAPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFV9</accession>
    <name>Q2HFV9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_00895</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220116.1">
        <property type="nucleotide sequence ID" value="XM_001220115.1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="124"/>
        </location>
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        </location>
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        <location>
            <begin position="489"/>
            <end position="598"/>
        </location>
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        <location>
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            <end position="309"/>
        </location>
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        <location>
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        </location>
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        </location>
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            <end position="423"/>
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            <end position="596"/>
        </location>
    </feature>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
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        <source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="641" mass="70462" checksum="3AFB28B3AA36572B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG30</accession>
    <name>Q2HG30_CHAGB</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CHGG_00824</name>
    </gene>
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        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ92589.1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TMA17"/>
    </dbReference>
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        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
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    </dbReference>
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        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="162" mass="16914" checksum="31B848FCCD279463" modified="2006-03-21" version="1">MSSEALPISPTRFAAALTDLPLSTLHLKVLELRNSIAHLDYSNEQLRPFAEGTATATATSTSTTTTAPPQQAPSSTTATAEPDADCADAIRENEGVIARMQERIALVRAEVERRGLGWAEFSERGGAGGREGEAGGCEWWGYRRGGGGGGGGLTVVVVWGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG40</accession>
    <name>Q2HG40_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Chromosome disjunction protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Ribosomal RNA-processing protein 44</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_00814</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220035.1">
        <property type="nucleotide sequence ID" value="XM_001220034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG40"/>
    <dbReference type="FunCoup" id="Q2HG40">
        <property type="interactions" value="991"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HG40"/>
    <dbReference type="GeneID" id="4386256"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00814"/>
    <dbReference type="eggNOG" id="KOG2102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002333_5_0_1"/>
    <dbReference type="InParanoid" id="Q2HG40"/>
    <dbReference type="OMA" id="GQVMRNN"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043628">
        <property type="term" value="P:regulatory ncRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09862">
        <property type="entry name" value="PIN_Rrp44-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000005">
        <property type="entry name" value="Exosome complex exonuclease dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000010">
        <property type="entry name" value="Exosome complex exonuclease DIS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000001">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
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        <property type="entry name" value="S1_domain"/>
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        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rrp44_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S1 motif" evidence="17">
        <location>
            <begin position="889"/>
            <end position="984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00077930"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00081547"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ92579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="987" mass="111175" checksum="DD40DFA73016F3CC" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGG6</accession>
    <name>Q2HGG6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">cAMP-dependent protein kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_00688</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8 9">Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
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        <property type="protein sequence ID" value="EAQ92453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001219908.1"/>
    </dbReference>
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        <property type="interactions" value="379"/>
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    <dbReference type="STRING" id="306901.Q2HGG6"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00688"/>
    <dbReference type="eggNOG" id="KOG1113">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018310_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGG6"/>
    <dbReference type="OMA" id="IASCHSM"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046827">
        <property type="term" value="P:positive regulation of protein export from nucleus"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097271">
        <property type="term" value="P:protein localization to bud neck"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010603">
        <property type="term" value="P:regulation of cytoplasmic mRNA processing body assembly"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000006">
        <property type="entry name" value="cAMP-dependent protein kinase type I-alpha regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012198">
        <property type="entry name" value="cAMP_dep_PK_reg_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000548">
        <property type="entry name" value="PK_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0114">cAMP</keyword>
    <keyword evidence="4 9 10" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="173"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="217"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ92453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="345" mass="37825" checksum="0315535A3BAF234C" modified="2006-03-21" version="1">MSGPGFTSPFGANSNPFGSSRLDTGAMQRVAEEDENDTVTSPTTPSFVQTAGYMFRGPFGGDSASEPQHSGLRSPPVSEGYPAQYNFGRRTSVSAESLKPVGDSYDNWAPPVHPKTSEQLGRLKQAMSGNFLFSHLNDVAKRFRFMRAFGRKKPILTQGNSRALSTSMSIAGAATVISAEPQCMLWALDRVTFRRILMESTFARRRMYEGFLEEVPLLSTLTPYERSKIADALESQKFPAGHTIIREGDPGHSFYLLEAGEAVAYRSGNDTPVKHYKKGDFFGELALLNDAPRAASVVSQTEVKVARLGKSAFQRLLGPVEGIMRRTKYVGVKTGVEEMDPLQMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGR5</accession>
    <name>Q2HGR5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219810.1">
        <property type="nucleotide sequence ID" value="XM_001219809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGR5"/>
    <dbReference type="STRING" id="306901.Q2HGR5"/>
    <dbReference type="GeneID" id="4387162"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00589"/>
    <dbReference type="HOGENOM" id="CLU_963122_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGR5"/>
    <dbReference type="OrthoDB" id="10440971at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="289" mass="28532" checksum="9F176B87299CEF4D" modified="2006-03-21" version="1">MGKLGKRIFEIDFDGKGVAEAEAAGTETGATGALDAEGKSTETEGSATPRSDCDGRPTGGRDTSGRETSGTEIEGSAADGTEIAGLETDGSELAGTELLVNAGMEGREAPGTETSGSETGGKETEGDSGFADTSEGSDGPRIEAPGKDTDTPTETPGMLTDIAGPVTAGSEAPGNDTEGKPKPIETPGNDTEAPFEAPETPTAGGVTDGSAADGTDSEGSPRDRDALTEISGRPTEELGTESEGTGTGITTAGPPATAEALALAGPPVNCARHCESWISTANVAAAPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH90</accession>
    <name>Q2HH90_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_00414</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219635.1">
        <property type="nucleotide sequence ID" value="XM_001219634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH90"/>
    <dbReference type="FunCoup" id="Q2HH90">
        <property type="interactions" value="344"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HH90"/>
    <dbReference type="GeneID" id="4387279"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00414"/>
    <dbReference type="eggNOG" id="KOG3408">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117291_2_2_1"/>
    <dbReference type="InParanoid" id="Q2HH90"/>
    <dbReference type="OMA" id="MKDHFRS"/>
    <dbReference type="OrthoDB" id="24683at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000299">
        <property type="entry name" value="Zinc finger protein 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="71"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ92179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="102" mass="11692" checksum="168935E1680822D2" modified="2006-03-21" version="1">MGVFAKRTKTKTRRRVRDVDQIKADLLSPRHLQLYKETKAAEDLPGFGRNYCVECAKWFETDSSLVLHRKGKPHKRRLKQLREGPYTHEEAAAASPGDVSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH92</accession>
    <name>Q2HH92_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_00412</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219633.1">
        <property type="nucleotide sequence ID" value="XM_001219632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH92"/>
    <dbReference type="STRING" id="306901.Q2HH92"/>
    <dbReference type="GeneID" id="4387277"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00412"/>
    <dbReference type="eggNOG" id="KOG2632">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084816_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HH92"/>
    <dbReference type="OMA" id="NTYPIVH"/>
    <dbReference type="OrthoDB" id="10257275at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="6">
        <location>
            <begin position="63"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ92177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="213" mass="23892" checksum="65B7980AF010C622" modified="2006-03-21" version="1">MPSNPTHMLKLGLQRTTSYIDHLPIFTKVVMCIMVAIEAAALLPGWRLKSWGRLEPDLVNFSTLYRTNTYPLMHIDAFHLTINFLGVVPLLERFEKEHGTLISVALFFGPFSTVPALIIWGFLLYAAEAIRANATVPYFIIWVGLGYLKFLVPPEVVMRFIETKLRLRSWSSFYVSVDQKTYGRDGVIPLTNVVPTVAPGVTGSNQRLGPAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHG9</accession>
    <name>Q2HHG9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_00335</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI91</accession>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
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    </evidence>
    <sequence length="110" mass="11669" checksum="D0C9673683C6C550" modified="2006-03-21" version="1">MAAEAKSNASADDMGGDYSWDEEYGSGAVLAAELGLGKPKPLMAKLNNYGGGQAVFEPVAKPGELYMWQSEVGEIDRIVSPTTLAEVKDLIATGKISTIKLEKVPRPTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI95</accession>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
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    <dbReference type="HOGENOM" id="CLU_015590_2_1_1"/>
    <dbReference type="InParanoid" id="Q2HI95"/>
    <dbReference type="OMA" id="FWTKHGY"/>
    <dbReference type="OrthoDB" id="416441at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="2">
        <location>
            <begin position="316"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="532" mass="60426" checksum="FA1997F041BD9E2D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HIA7</accession>
    <name>Q2HIA7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH-ubiquinone oxidoreductase 23 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_00047</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219268.1">
        <property type="nucleotide sequence ID" value="XM_001219267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HIA7"/>
    <dbReference type="STRING" id="306901.Q2HIA7"/>
    <dbReference type="GeneID" id="4386566"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00047"/>
    <dbReference type="eggNOG" id="KOG3256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067218_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HIA7"/>
    <dbReference type="OMA" id="QFFRAPY"/>
    <dbReference type="OrthoDB" id="204405at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3270:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004538">
        <property type="entry name" value="PRK05888.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004539">
        <property type="entry name" value="PRK05888.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF20">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="9" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="115"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="154"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ91812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="223" mass="25439" checksum="8523E88865E4A990" modified="2006-03-21" version="1">MIAPSAASLGARQMSMVRVPSTLFRTVPSQMLVARRGYATPAGPPPKNFRLKPPTTWDQEKESTFDKVGKYFLLTEMFRGMYILMEQFFRPPYTIYYPFEKGPISPRFRGEHALRRYPSGEERCIACKLCEAVCPAQAITIEAEERADGSRRTTRYDIDMTKCIYCGFCQESCPVDAIVESPNAEYATETREELLYNKEKLLSNGDKWEPELAAAIRADAPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HID8</accession>
    <name>Q2HID8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219237.1">
        <property type="nucleotide sequence ID" value="XM_001219236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HID8"/>
    <dbReference type="GeneID" id="4388267"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00016"/>
    <dbReference type="eggNOG" id="ENOG502RMEJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052361_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HID8"/>
    <dbReference type="OMA" id="FEVNDFD"/>
    <dbReference type="OrthoDB" id="3360610at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004493">
        <property type="term" value="F:methylmalonyl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046491">
        <property type="term" value="P:L-methylmalonyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07267">
        <property type="entry name" value="THT_Oxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000034">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000039">
        <property type="entry name" value="Trihydroxytoluene oxygenase (AFU_orthologue AFUA_8G02470)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051785">
        <property type="entry name" value="MMCE/EMCE_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048:SF3">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="161"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="317" mass="36165" checksum="665D1406B0B902F6" modified="2006-03-21" version="1">MAQHHTKINLVRIAHVYYTHSDLAKAREFLSDFGFTVADDRGDTVYYRGYGTEPFVYCAKKGEANEFGGAAFLVESMADLELASNTLPQATAIEDSDAPGGGKRVTFRDPVDSFPFHLIYGHTLVEKTAHLPELNYNYPETKHRAVNKTQRFKQGPAPVHKLGHFGCCVTDFVKAFEFYTTRFNLKPTDIITDSTGKDITAFFHLDRGMEQVDHHTFFFFEGPKYHVHHSSFEVHDFDIQSLGHQWLREKDYDLVWGVGRHVLGSQIFDYWWDRSGFVMEHYVDGDLVDETTPVTRSPAGPDSLHIWGPPLPPTFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMB3</accession>
    <name>Q2GMB3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226158.1">
        <property type="nucleotide sequence ID" value="XM_001226157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMB3"/>
    <dbReference type="GeneID" id="4397209"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10891"/>
    <dbReference type="eggNOG" id="ENOG502SSHG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138695_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GMB3"/>
    <dbReference type="OMA" id="FATARNC"/>
    <dbReference type="OrthoDB" id="4186099at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208796" evidence="1">
        <location>
            <begin position="22"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="87" mass="9897" checksum="670156E67857B1AC" modified="2006-03-21" version="1">MTKPVTILFALAGILLPLAEAKACKEGLDYWDYLREIDNELKRVGLPTQDPYERHSLFHCSSDGWIRWNVYCGNCIDGGSGKDDFCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GME4</accession>
    <name>Q2GME4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_10860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226127.1">
        <property type="nucleotide sequence ID" value="XM_001226126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GME4"/>
    <dbReference type="ESTHER" id="chagb-q2gme4">
        <property type="family name" value="AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="4397148"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10860"/>
    <dbReference type="eggNOG" id="ENOG502S0WE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013364_5_2_1"/>
    <dbReference type="InParanoid" id="Q2GME4"/>
    <dbReference type="OMA" id="CYANEKP"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="189"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="4">
        <location>
            <begin position="548"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ83042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="678" mass="73885" checksum="0EFE1409E986DA20" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNQ0</accession>
    <name>Q2GNQ0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="14">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_10404</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="14"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228331.1">
        <property type="nucleotide sequence ID" value="XM_001228330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNQ0"/>
    <dbReference type="FunCoup" id="Q2GNQ0">
        <property type="interactions" value="653"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GNQ0"/>
    <dbReference type="GeneID" id="4396951"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10404"/>
    <dbReference type="eggNOG" id="KOG1383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028929_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GNQ0"/>
    <dbReference type="OMA" id="AFWQLRG"/>
    <dbReference type="OrthoDB" id="10254570at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2150:FF:000002">
        <property type="entry name" value="Sphinganine-1-phosphate aldolase Bst1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000020">
        <property type="entry name" value="sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ84000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="570" mass="62869" checksum="77D9D5CD9EF72C4C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNV5</accession>
    <name>Q2GNV5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small EDRK-rich factor-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228276.1">
        <property type="nucleotide sequence ID" value="XM_001228275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNV5"/>
    <dbReference type="GeneID" id="4397046"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10349"/>
    <dbReference type="eggNOG" id="KOG4488">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165034_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GNV5"/>
    <dbReference type="OrthoDB" id="18018at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="87" mass="9270" checksum="7075BB55FBF57EBB" modified="2006-03-21" version="1">MARGNQRDKAREANQKKQAATKKSHGMSGSELAKAKEVAAQKMREKQAAGTRRPSPPVPNLPPPLQPAILTCILADAKKAEAATAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPB4</accession>
    <name>Q2GPB4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ERCC4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_10190</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EME1/MMS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228117.1">
        <property type="nucleotide sequence ID" value="XM_001228116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPB4"/>
    <dbReference type="STRING" id="306901.Q2GPB4"/>
    <dbReference type="GeneID" id="4396115"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10190"/>
    <dbReference type="eggNOG" id="ENOG502R8ER">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013160_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPB4"/>
    <dbReference type="OMA" id="AIFTQHI"/>
    <dbReference type="OrthoDB" id="343092at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20085">
        <property type="entry name" value="XPF_nuclease_Mms4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.670:FF:000004">
        <property type="entry name" value="Crossover junction endonuclease EME1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033310">
        <property type="entry name" value="Mms4/EME1/EME2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047521">
        <property type="entry name" value="XPF_nuclease_EME1_ascomycetes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077:SF5">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MMS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077">
        <property type="entry name" value="EME1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="15">
        <location>
            <begin position="400"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="305"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAQ83786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="714" mass="79562" checksum="2A77E4003989C994" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPB6</accession>
    <name>Q2GPB6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">General transcription and DNA repair factor IIH subunit TFB4</fullName>
            <shortName evidence="14">TFIIH subunit TFB4</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">RNA polymerase II transcription factor B subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_10188</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the TFB4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228115.1">
        <property type="nucleotide sequence ID" value="XM_001228114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPB6"/>
    <dbReference type="FunCoup" id="Q2GPB6">
        <property type="interactions" value="1008"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GPB6"/>
    <dbReference type="GeneID" id="4396260"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10188"/>
    <dbReference type="eggNOG" id="KOG2487">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040211_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPB6"/>
    <dbReference type="OMA" id="QGCDITS"/>
    <dbReference type="OrthoDB" id="17307at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="408" mass="41560" checksum="5E5EF67EB3A08D7A" modified="2006-03-21" version="1">MSVQDAVDASEHYEVYNTDDIPSLCTIVIDTNPRAWAALTDVLPISKAIANILVFVNAHLAFSNSNQVSIIAAHTNRAVWLYPAPPRQGRSQDVDMQNAASDSKSSSANKYPQFAQIENSLLTSLRALINDTTDADLASTTTQISGALTLALAHINKTALSFTASSTAAHAATNTGTAMTAGTAVGPNPVSSTSMNGGGLAGLHARILILSVSDSAPAQYIPTMNAVFAAARARIAIDTLSLRAAEPRGLLQYLMFGFGSGTAPSNPSGGADSGKGPASSKTATAGGQGTTAAGGRHPRTAKLGLGASVAELLVTPSADAVDFRAACFCHRNVIDTGFVCSVCLSIFCEVPDGGECLTCGTALALGNYGKRPVVAGGSSNVSNGSSSSSASPGVGRKEKRKLGTNGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPM3</accession>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
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                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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            <end position="131"/>
        </location>
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            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ83677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="219" mass="22985" checksum="3B9025FB20C4F932" modified="2006-03-21" version="1">MAEAECPWRRETRWCPRDSSGWCGQHNDNCHRGRSEQRGLMPAEVDEDTTTSHTQAGPMPIQEGLTSGAAFAPVFVAAPLPITQAPAVTPQPCRVASPSPPASVVWSVGPFRASLLPPAAAPQESQSAPAPFRLEPPSPTTLRALGLLPGVPAPIVGSPASTAHDHSVWKASVTACDPFMGYEEAGSPTQGSPTQGSSTQGSLPNVLPLDSDQFKSRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPW0</accession>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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                <person name="Untereiner W.A."/>
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            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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        <subcellularLocation>
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        </subcellularLocation>
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    <dbReference type="OrthoDB" id="6770063at2759"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Multidrug resistance protein D"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF39">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
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        <location>
            <begin position="563"/>
            <end position="589"/>
        </location>
    </feature>
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        <location>
            <begin position="96"/>
            <end position="589"/>
        </location>
    </feature>
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        <location>
            <begin position="14"/>
            <end position="86"/>
        </location>
    </feature>
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        <location>
            <begin position="622"/>
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        </location>
    </feature>
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        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
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        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ83590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="658" mass="71145" checksum="199D2D8933F51E7C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQ08</accession>
    <name>Q2GQ08_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Programmed cell death protein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_09946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227873.1">
        <property type="nucleotide sequence ID" value="XM_001227872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQ08"/>
    <dbReference type="FunCoup" id="Q2GQ08">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GQ08"/>
    <dbReference type="GeneID" id="4396795"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09946"/>
    <dbReference type="eggNOG" id="KOG2061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031771_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GQ08"/>
    <dbReference type="OMA" id="MPGPWAD"/>
    <dbReference type="OrthoDB" id="443682at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524:SF1">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 2 C-terminal" evidence="2">
        <location>
            <begin position="289"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="418" mass="45312" checksum="8B1B532E558D9E85" modified="2006-03-21" version="1">MAPYDSDSSGGEEDDFTETNVLLGISANERLQDWLDTDKAPSAALARCKVCKDLMVLILQLNAELPERFPTHDRRLYVLACKRKSCRRKEGSIRAIRGVRVSAEASTAIPEKDTQPEEKAIPKPPSQGLGDAIFGAKPATASGTPRANPFATPSSQPTNPFAPKPSSATPTNPFAKQQLAATTPAPEPSKPDLEATTTDLPKTFAQTLSLNNPQATQGPPPPPEPWPEVSAQPAPYPIRWLSDAEYETLDPITLPSVPQATTVMDIDSGEGPGSSGGKEDKEVFESSMDATFQKFADRVGQNPEQCIRYEFAGQPLLYSKGDAVGKLLHVSEKEKVATSKGLPRCGNCGAGRVFEVQLTPQAIQELECEEDGLDGMDWGTVIVGVCERDCQERGVEAREAGYLEEWVGVQWEELTMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQ27</accession>
    <name>Q2GQ27_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_09927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227854.1">
        <property type="nucleotide sequence ID" value="XM_001227853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQ27"/>
    <dbReference type="GeneID" id="4396290"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09927"/>
    <dbReference type="HOGENOM" id="CLU_1250526_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQ27"/>
    <dbReference type="OrthoDB" id="5366688at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="221" mass="23784" checksum="5D1C13719D49F777" modified="2006-03-21" version="1">MRFQAPQLGAMGVTFIVMRAFQFASLIAVIGLCANFINGITTAEHDPPAELIGTLTVLDRTICYEIKAAWGKQKTKQEAWNRAPAAVAAAPYFPPPPLAPTRDRSRARNQPPNPRIITTSPPRFSCDSDDSNHATEPTATNNNSPAPTPRAYAPHHRSTPANPHPSPSPSPPNQKTPTPNPTASLRSLSRGPPSTRRQPQRTARTLTGPPPAPPQTRPPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQ39</accession>
    <name>Q2GQ39_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_09915</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227842.1">
        <property type="nucleotide sequence ID" value="XM_001227841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQ39"/>
    <dbReference type="GeneID" id="4396497"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09915"/>
    <dbReference type="eggNOG" id="ENOG502QR6D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013783_3_3_1"/>
    <dbReference type="InParanoid" id="Q2GQ39"/>
    <dbReference type="OMA" id="TECIAND"/>
    <dbReference type="OrthoDB" id="5230128at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF39">
        <property type="entry name" value="PEPTIDASE S53 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S53" evidence="11">
        <location>
            <begin position="148"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ83511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="415" mass="45293" checksum="CB4357C60D7F994C" modified="2006-03-21" version="1">MSSKTDTQFRPNGRKCRGQMATGFRTPPINVSKAERLLTTTYHTYRHVDGDVAIRAPEWSLPAHLHEHIDAIHPTNAFFRPSLQTRAVPVERRGFETAPLGLGVDDLPSYEELAAIDKKEMGHMDVPLSSDFALPGAITVDEACNKLATSPLCLRTLYGTLNYTPQVPNKTSVALVNYLGQVNNRSDIAIFLQRYRPDAFPGAADFWTEIVSGGTDQQTPVTPEQVAAARTVIALEGNLNAETILGLAHPIPLKAYNVGGKPPFQSTAFTTANKNEPYLEWTSHMLSKSDDELPRVISTSYADEEQSVPLLYARRACAGFAALGARGVSLLFASGDEDVGQDDKCFAHDDQTRKMFLPVFPASCPYVTAVGGTRHWAPEMAWFDARSGFVTGSALATTFPSPSIKNMTCRSTLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQ69</accession>
    <name>Q2GQ69_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Long-chain-alcohol oxidase</fullName>
            <ecNumber evidence="5 12">1.1.3.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_09885</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Long-chain fatty alcohol oxidase involved in the omega-oxidation pathway of lipid degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a long-chain primary fatty alcohol + O2 = a long-chain fatty aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:22756"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17176"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="EC" id="1.1.3.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.20" evidence="5 12"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227812.1">
        <property type="nucleotide sequence ID" value="XM_001227811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQ69"/>
    <dbReference type="GeneID" id="4396885"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09885"/>
    <dbReference type="eggNOG" id="ENOG502QSD8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008878_3_1_1"/>
    <dbReference type="InParanoid" id="Q2GQ69"/>
    <dbReference type="OMA" id="YGVIYET"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046577">
        <property type="term" value="F:long-chain-alcohol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012400">
        <property type="entry name" value="Long_Oxdase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056:SF12">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028937">
        <property type="entry name" value="Lg_Ch_AO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="14">
        <location>
            <begin position="286"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="15">
        <location>
            <begin position="566"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR028937-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAQ83481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="723" mass="78317" checksum="7016C798F75DEC77" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQG7</accession>
    <name>Q2GQG7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Methionine aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_09787</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Associates with the 60S ribosomal subunit of the 80S translational complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="11"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227714.1">
        <property type="nucleotide sequence ID" value="XM_001227713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQG7"/>
    <dbReference type="FunCoup" id="Q2GQG7">
        <property type="interactions" value="790"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GQG7"/>
    <dbReference type="MEROPS" id="M24.017"/>
    <dbReference type="GeneID" id="4397067"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09787"/>
    <dbReference type="eggNOG" id="KOG2738">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_2_1_1"/>
    <dbReference type="InParanoid" id="Q2GQG7"/>
    <dbReference type="OMA" id="FYGDHAY"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000010">
        <property type="entry name" value="Methionine aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="12">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ83383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="400" mass="44741" checksum="9BABB1D3ACA01F1E" modified="2006-03-21" version="1">MAEEPPTKRKCLGVDCENEASSLQCPKCLSIGVKDSFFCSQDCFKKNWATHKKTHAQENKTGYYNPFPTFNFTGPLRPVYPLSEKREVPKSIPHPDYAEDGIPKLGRSIVRSNKFQQLDAKAQDGMRKVCRLAREVLDIAAAAIRPGITTDEIDEIVHKACVERNSYPSPLNYNHFPKSVCTSVNEVICHGIPDKRILLDGDIVNLDVTLYHEGYHGDLNETYYVGDRAKADPDTVRVTETARECLEEAIKLVKPGTLIREFGNVIEAHAKSKNCSVIRTYVGHGINSIFHCPPNIPHYAKNKAVGECKPGMTFTIEPMIALGKYRDVTWPDNWTSTTVDGKKTAQFEHTLLVTETGVEILTARKEDSPGGPIPMPCCSLQQDLCLSCRRRIPMINCLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQN8</accession>
    <name>Q2GQN8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutamate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_09716</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227643.1">
        <property type="nucleotide sequence ID" value="XM_001227642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQN8"/>
    <dbReference type="STRING" id="306901.Q2GQN8"/>
    <dbReference type="GeneID" id="4396636"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09716"/>
    <dbReference type="eggNOG" id="KOG0629">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_877162_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQN8"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677:SF8">
        <property type="entry name" value="CYSTEINE SULFINIC ACID DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ83312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="34006" checksum="2D5F26F0B6AB27DD" modified="2006-03-21" version="1">MDTTHGDKSLNRADEVEHLIDAVKALIVPFVREADEAIPSRAAGELLPNAQGVVKNTLVYAQRPEDLVRELAFNLPEGKGRGEEGLLETIKDVLKYSVNTWDQGFLDKLVGVASELLLAALNTNSANPQSNNGAPGPLILYTSVHGHYSVEKAAVTCGLGSASVWTVPVDATGRMDPSALRALIQRAQSEGKTPLYVNATAGSTVLGSYDPFEAIADICAEFNLWMHIDASWGGPAIFSPTHRRKLAGSHRAHSLTSNPHKMLNVPVTCSFLLGPDTAVFHRANTLPAGYLFHTTTTTTTTTTTTTSEPTPCIPRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GR32</accession>
    <name>Q2GR32_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_09572</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227499.1">
        <property type="nucleotide sequence ID" value="XM_001227498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GR32"/>
    <dbReference type="STRING" id="306901.Q2GR32"/>
    <dbReference type="GeneID" id="4395542"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09572"/>
    <dbReference type="eggNOG" id="KOG1121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1089903_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GR32"/>
    <dbReference type="OrthoDB" id="5078122at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="8"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="216"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ85558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="255" mass="28099" checksum="92DE83A98DA6FC66" modified="2006-03-21" version="1">MLDPGNTELDRYLQLDPAHLQGVQDPLQWWVSQRSAFPTLSQLALDILAIPAMSADCERTFSLSKLTLTTQRLSMAPRTLEHTQCLKNWIERGSTCGLWTFCFDEYRTLRAFAPMAGDLPVHHVQMMLNKFVSGAGVAGGRHHMPGHPQPQNPLAVGPSKAAIRQLENDAAVMKSLKSVTAAPQLRVEVLPWRTGIEVKQYHESMTHEAELTACADSSASSPFLPSSTAKQLERPASHPRTRIKAGEAMRLVSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRM7</accession>
    <name>Q2GRM7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227304.1">
        <property type="nucleotide sequence ID" value="XM_001227303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRM7"/>
    <dbReference type="GeneID" id="4395652"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09377"/>
    <dbReference type="eggNOG" id="KOG4525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009601_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GRM7"/>
    <dbReference type="OMA" id="NDNGECA"/>
    <dbReference type="OrthoDB" id="74460at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053002">
        <property type="entry name" value="Metalloproteinase_M10B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021917">
        <property type="entry name" value="Unchr_Zn-peptidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054:SF2">
        <property type="entry name" value="MIP04191P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054">
        <property type="entry name" value="ZINC METALLOPROTEINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12044">
        <property type="entry name" value="Metallopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="625" mass="68721" checksum="AF1E1A58C9304096" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRR9</accession>
    <name>Q2GRR9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_09335</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227262.1">
        <property type="nucleotide sequence ID" value="XM_001227261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRR9"/>
    <dbReference type="GeneID" id="4395679"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09335"/>
    <dbReference type="eggNOG" id="ENOG502SHEC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036005_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GRR9"/>
    <dbReference type="OMA" id="TAYYAQP"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000005">
        <property type="entry name" value="TfdA family taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="70"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ85321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="401" mass="44873" checksum="A0A4AAEEAC837C06" modified="2006-03-21" version="1">MAPSAVESVQQTVEDIKQKVLPTQEKQATSGGEVKPIQNTSRHEDVLAERLEGHKEPLKLSGALDHLEHFDVTPVIGREYVDVDLVELLRAPNSDELLRDLAITISQRGVVFFRSQDNLTDDLQKELVDRLGKLSGKPETSGLHIHPVSNAAREHGGNDNEISVISSEQTKKLYADRLQGAFTGGRHRQSGKNQWHSDITFEPIPSDYALLRLTQLPKTGGDTLWASGYELYDRISPTLRHFLDTLTATYAQPLFNEAARRNNFTLYSGARGAPENTGDTLDAVHPVVRTNPVTGWRSVFAVGHHVQRIHGLSDEESKHFLEWFVRLVVENHDLQVRLRWKAVNDVAIWDNRSVYHAATPDYIFEEGLGERKGSRAVSLGERPYFDPASTSRREALGTVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRS5</accession>
    <name>Q2GRS5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">L-asparaginase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_09329</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227256.1">
        <property type="nucleotide sequence ID" value="XM_001227255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRS5"/>
    <dbReference type="STRING" id="306901.Q2GRS5"/>
    <dbReference type="GeneID" id="4395524"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09329"/>
    <dbReference type="eggNOG" id="KOG1592">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021603_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GRS5"/>
    <dbReference type="OMA" id="VCLDRWG"/>
    <dbReference type="OrthoDB" id="2262349at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04701">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF43">
        <property type="entry name" value="ASPARAGINASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="252"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="327"/>
            <end position="330"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="3">
        <location>
            <begin position="223"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ85315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="48816" checksum="67E6EAF20B28A2AE" modified="2006-03-21" version="1">MEYKAQPPSPLGRRIQPRLIIHGGAGNITPATLTPKRYAEFRTALLTIISHAHTFMTTPTPTSTPPKLPSSLAVATHAVTLLEDNPLFNAGHGAVFTRDGLHELEASVMVSRGHAKRGVGVSGLRRVRNPVRLAREVLERGERDLKGLGLGEGTGLDVPSAQGHTHLHGAAAEQLAEGYGLVMVEQGYFWTRRRWEEHVRGLERERERGGLGTWCKEEYVPQGTVGAVAVDEEGVVCVATSTGGLTNKVTGRIGDTPTVGAGFWAEEWVESAGGSGAAWASYGPAVVLSGALKGVMAECFPTPWMYNPLASAAGDLTRTRSVAVSGTGNGDSFLRTAAARTVGSIARFDGDTSTAAVTKVTGPGGELQNSAGDRWGKTGEGEGGMIGIECTVVKDGEGRVVVARSELLQDFNCGGMFRAWVDERGVAFARVFRDDEEVPDAYVGEGKPENPRMWSGEKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSK6</accession>
    <name>Q2GSK6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavoprotein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_09048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226975.1">
        <property type="nucleotide sequence ID" value="XM_001226974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSK6"/>
    <dbReference type="STRING" id="306901.Q2GSK6"/>
    <dbReference type="GeneID" id="4394725"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09048"/>
    <dbReference type="eggNOG" id="KOG0672">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019412_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSK6"/>
    <dbReference type="OMA" id="HVHVLDF"/>
    <dbReference type="OrthoDB" id="70387at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF21">
        <property type="entry name" value="FLAVOPROTEIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
        <property type="entry name" value="Pseudo ankyrin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="2">
        <location>
            <begin position="108"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ85034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="601" mass="68470" checksum="D9702D1EEB5A2E1B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-24" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSM6</accession>
    <name>SEC13_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Protein transport protein SEC13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SEC13</name>
        <name type="ORF">CHGG_09028</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. SEC13 is required for efficient mRNA export from the nucleus to the cytoplasm and for correct nuclear pore biogenesis and distribution.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226955.1">
        <property type="nucleotide sequence ID" value="XM_001226954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSM6"/>
    <dbReference type="SMR" id="Q2GSM6"/>
    <dbReference type="FunCoup" id="Q2GSM6">
        <property type="interactions" value="951"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GSM6"/>
    <dbReference type="GeneID" id="4394871"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09028"/>
    <dbReference type="eggNOG" id="KOG1332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032441_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GSM6"/>
    <dbReference type="OMA" id="IWKEEGD"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902953">
        <property type="term" value="P:positive regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070863">
        <property type="term" value="P:positive regulation of protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000017">
        <property type="entry name" value="SEC13 homolog (S. cerevisiae)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0931">ER-Golgi transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0509">mRNA transport</keyword>
    <keyword id="KW-0906">Nuclear pore complex</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000295411" description="Protein transport protein SEC13">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="41"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3">
        <location>
            <begin position="87"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4">
        <location>
            <begin position="133"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5">
        <location>
            <begin position="197"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 6">
        <location>
            <begin position="245"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q04491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="290" mass="32042" checksum="27027350BF836DDA" modified="2006-03-21" version="1">MIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAHPKYGNILASAGYDGKVLIWREQNGAWQRIYDFSLHKASVNVVSWSPHEAGCVLACASSDGNVSVLEFKDNNSWEHSIFHAHGLGVNSVSWAPATNPGSIVSSKPSPKSTGNRRFVTGGSDNALKIWAFDAATGAYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTSDPANPQQWNCKVLGFDAAVWRVSWSLSGNVLAASGGDNKVTLWKENLKGEWECVKSIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSR2</accession>
    <name>Q2GSR2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_08992</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226919.1">
        <property type="nucleotide sequence ID" value="XM_001226918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSR2"/>
    <dbReference type="FunCoup" id="Q2GSR2">
        <property type="interactions" value="238"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GSR2"/>
    <dbReference type="GeneID" id="4395259"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08992"/>
    <dbReference type="eggNOG" id="KOG2684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023643_5_3_1"/>
    <dbReference type="InParanoid" id="Q2GSR2"/>
    <dbReference type="OMA" id="PTHEFIR"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099115">
        <property type="term" value="C:chromosome, subtelomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032041">
        <property type="term" value="F:histone H3K14 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141222">
        <property type="term" value="F:histone H3K4 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046969">
        <property type="term" value="F:histone H3K9 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046970">
        <property type="term" value="F:histone H4K16 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902794">
        <property type="term" value="P:siRNA-independent facultative heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF9">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="9">
        <location>
            <begin position="167"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="330"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="506"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="513"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ84978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="559" mass="61916" checksum="10C5F0DF3D644430" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GT83</accession>
    <name>Q2GT83_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_08821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226748.1">
        <property type="nucleotide sequence ID" value="XM_001226747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GT83"/>
    <dbReference type="GeneID" id="4394832"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08821"/>
    <dbReference type="HOGENOM" id="CLU_1440890_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GT83"/>
    <dbReference type="OrthoDB" id="5060046at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="22333" checksum="F4F39D0B27E80580" modified="2006-03-21" version="1">MCRDVYGMWEFVMDVMQRRQQSLGWRLVPRACFGCFRVREKEQFSPQQYRLSRKYNHGEYWRRRCWECLRRFYHPQLADTEARARFHRQVLCGVCKCLRYADEDCRGCVVKSAQIAEWQRLSELSGKKRVPRVDWMTDADVMVPSWLDEEATTAKEADEAEVTEPDKAAVKRGIDFLVAFTGLKRFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTX7</accession>
    <name>Q2GTX7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyl transferase family 25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_08577</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226504.1">
        <property type="nucleotide sequence ID" value="XM_001226503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTX7"/>
    <dbReference type="GeneID" id="4395468"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08577"/>
    <dbReference type="eggNOG" id="ENOG502S152">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032992_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GTX7"/>
    <dbReference type="OMA" id="PPIFAHH"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF53">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 25" evidence="4">
        <location>
            <begin position="46"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ84563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="493" mass="54107" checksum="A290E83E65FC3D1D" modified="2006-03-21" version="1">MFSRHRILAASLAVGITLFLWFRTPQWPIIAINTPSPEILNSTLGHIFAINLPSRTDRRDALALAGALSELDITWVDGVLGKDVLDKTLPGDPNSRQGNGGFTTGNKGSWRAHMDVLQRIVHENVTSALILEDDADWDLRLKRQMQVFAQASRAFTQPSNGQSLAEQYSTHADPELAITQLPLGTRPRLTPYGDDWDVLWLGHCGTDFPGTAALRVTIPDDMTVPSPNHLKPHPFALQDALAEDYPPHTRVVHPSRGTVCTQAYAVSQQGARKLLWQFGLQTLTMGWDLMLRDWCDDMYSPLSSDTAGDDGDDEKRRAPICVTVQPPLFSHHYGKGAASDIMAPGGGFVNKDKEMTPYVRVSVRMNMESVCYKNPDPRSPFVGTSLQLHSPPGMQQIATQPEHVAEKPPAETLTNQCEGVGQTSALQSIPKGVQQQGIATTMADAHEPALRSAAAASHLPTRLPCTSHNPPTVRRVSRLDVTLRTGRRPFPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTZ1</accession>
    <name>Q2GTZ1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Solute carrier family 40 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_08563</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226490.1">
        <property type="nucleotide sequence ID" value="XM_001226489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTZ1"/>
    <dbReference type="GeneID" id="4395275"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08563"/>
    <dbReference type="HOGENOM" id="CLU_713714_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTZ1"/>
    <dbReference type="OrthoDB" id="4582883at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208445" description="Solute carrier family 40 protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ84549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="42818" checksum="1A2B30F0B74BFEBF" modified="2006-03-21" version="1">MHSLLTFAFARPLLLFCVPSALGAVLLPLPPQRLPPKRHFCSTTAPITNTTTLCPTTPEWSGECPFLSRVLPPRRPQKTPPQPPPSTNPTNPSRCSSPVSILTILAVVTIIEAASTLMQGHDRVRRQLFRLRGTLFRLPDKQSPYWTPASGTVSAFTTFLFQVLLPAIISWSENKSQFSFGSLLGMWTMRPRGTFVMFALMRLIGWGGFKFTAFDAIVTESILDVIALPFAVTAVLTDHGPDGEGAKGCGIQGYEAVEDDVRVGMVYASFGWGTAAGVISSLVLAQFVIMSFNKRLTQEEMAEKDEEEAWQGRWSWWGRVLLREKRQLVPIIVAMGTMISNWVLWGRTGYCEAQDGVATLVLGIIHQLFIPLLRACFGADPDLVEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUC9</accession>
    <name>Q2GUC9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_08425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226352.1">
        <property type="nucleotide sequence ID" value="XM_001226351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUC9"/>
    <dbReference type="STRING" id="306901.Q2GUC9"/>
    <dbReference type="GeneID" id="4394673"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08425"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035565_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUC9"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ84411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="41736" checksum="A888F9E0AFD61B55" modified="2006-03-21" version="1">MHDLETLKSGGYRKCWPQPNSRFQDAVSFSNCNFKVFPRELASCLALESVGFRNNGMEEVLEDTFPPLLRYLVLTGNRITTLPSSIGRCDHLQECRLTGNQLRGLPTEMANCKELTLLRLSSNRLSVLPSWLFTLPKLAFLSFNSNPCASPTTNGLHAPRGLASIAWSDLEVQQPIDAHTSQGLWHQSPHYAEDVAIKLFRSPARGVENEDNNNDDDALTVPAALSMLTGLAHCLAHLHARGMAHGSLDPRHILASAADQHALLTGFRAATVYGHGHGHGHGLGAGSENGRGVERVEVLAFGRVVEYVLGAAAAAAAAGGGGGDDDVDVDEEKRKEREAVEEGLGELGGRCVAVDVAARPGFAEVVEVLEGLMGWRGMMRIPDVEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUE3</accession>
    <name>Q2GUE3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_08411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226338.1">
        <property type="nucleotide sequence ID" value="XM_001226337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUE3"/>
    <dbReference type="STRING" id="306901.Q2GUE3"/>
    <dbReference type="GeneID" id="4395540"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08411"/>
    <dbReference type="eggNOG" id="ENOG502RS6B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070655_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUE3"/>
    <dbReference type="OMA" id="REREWWG"/>
    <dbReference type="OrthoDB" id="3596146at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="272" mass="29405" checksum="E701948B0A4C35FE" modified="2006-03-21" version="1">MRGTTAAGVGARVLGEIEETTLDEVLASLRSSLLQGPNTNDNKAGNIPTSIVRPPIFPIDPLNDLVNRHFRATQSVPLALTGRPHELIYVLVATLIAPPYEKTVAIVDFEGRFDPLRLLATPIEGAAATGSMILEPKPKTAVQRSDLDHVHVLRAARGNFTHIADCVGSIEEYMLYGSHRSRGREWWGTIVIGGGLNPSGSASVAASAKVAVTADWKGWLRVDRAEVSTFWDMSAEEALVDREKRQAAVEAAGWLATSPWGGFSICKRDMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVA8</accession>
    <name>Q2GVA8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225752.1">
        <property type="nucleotide sequence ID" value="XM_001225751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVA8"/>
    <dbReference type="STRING" id="306901.Q2GVA8"/>
    <dbReference type="GeneID" id="4394571"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08096"/>
    <dbReference type="eggNOG" id="ENOG502RJ72">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_762904_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GVA8"/>
    <dbReference type="OrthoDB" id="5414787at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="363" mass="40464" checksum="0F5F92C87A351AB7" modified="2006-03-21" version="1">MDQDIQTSMQRKLPCAFRLELVGCASPSNLDDDEINPNVEDVPISRPLDEITENHLQAYAWSTLKIRTQASELLARSRTLGCPDEVLKIGRELEGKLNDISKFFPPIPGPPQFGPDSSYRKWYHCVRLDLHVRLSLLVLYEPFALGYHNCPEEIQRAYLTSCLAVLTYLKDAHSAGAPTIPRKELSVLYEAVADAAYGVCYFVKQARGPDEHGEENRPEILGCKVGDMLQIVDVVLEKWLGFVKLTDSRHFGDLIAVSIMWEMLQTGTPDDKVGKMQMRLDRILAFCSRRVPWGKLRFSSASAGSGSASQTAASVSQVQSRGAKAPASGSQVQSRGSKAPELPPKATWGDLSRYWDRLTRRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVS9</accession>
    <name>Q2GVS9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2293 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_07925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225581.1">
        <property type="nucleotide sequence ID" value="XM_001225580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVS9"/>
    <dbReference type="GeneID" id="4394124"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07925"/>
    <dbReference type="eggNOG" id="ENOG502SQ7Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006657_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GVS9"/>
    <dbReference type="OMA" id="FITLPPR"/>
    <dbReference type="OrthoDB" id="5288828at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018744">
        <property type="entry name" value="DUF2293"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38113">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38113:SF1">
        <property type="entry name" value="DUF2293 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10056">
        <property type="entry name" value="DUF2293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2293" evidence="2">
        <location>
            <begin position="63"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ86672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="739" mass="81684" checksum="58EEC7660628F1FD" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GW11</accession>
    <name>Q2GW11_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_07843</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225499.1">
        <property type="nucleotide sequence ID" value="XM_001225498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GW11"/>
    <dbReference type="STRING" id="306901.Q2GW11"/>
    <dbReference type="GeneID" id="4393158"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07843"/>
    <dbReference type="eggNOG" id="KOG0271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_6_16_1"/>
    <dbReference type="InParanoid" id="Q2GW11"/>
    <dbReference type="OMA" id="NINARIF"/>
    <dbReference type="OrthoDB" id="4576410at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050349">
        <property type="entry name" value="WD_LIS1/nudF_dynein_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44129">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="201"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="754"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="796"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ86590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="931" mass="102978" checksum="0F1BA9455F035A6F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX25</accession>
    <name>Q2GX25_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225135.1">
        <property type="nucleotide sequence ID" value="XM_001225134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX25"/>
    <dbReference type="STRING" id="306901.Q2GX25"/>
    <dbReference type="GeneID" id="4393502"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07479"/>
    <dbReference type="eggNOG" id="ENOG502REH8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027433_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GX25"/>
    <dbReference type="OrthoDB" id="3508621at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="485" mass="52086" checksum="DC84CEAF05230ADB" modified="2006-03-21" version="1">MAKRVTRDSFVSPHNNQLARELVSKSNRSSYLTAYLNEGLRDVGAPSYLHPLPECGYFSMVRYWQVMATTHTKGSGTDGPKTDKSQAEKEDARGRPTTPVEQQGSGGPSTVATPPRQILPPSNTPSDFRTPAAVSHPAAKGGADNPPSADESYVNVALLLLLQTISQGFHKHFSDLHWVPPRLALHLKVPVFNPATHTVDNKLLLEARVDGYLCRGKAGPSWEKPMAICEAKSGTRSHPLNEGLLQNSNSGKKRRLMISQNLNDIYIIIGEYGPSYEQYIRNAPWRNARFSHVPEAACPARHRRYQGWDKKVVGNAVGRVKATLTSRNGGPGGPGGNGSDLSNSGQAPGTGRVTRSTTAALDLPTVGGFLVMHRFGPWRTDDPENMSNFIRRLLGFMLELYGNRAASPPNSRSAPTTGHHGPLVIGTRRPSTTGYRGPAATSDRPASTTGSRAPSATGDRATGSRAPSATSRSSSTTSNQAPSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXL3</accession>
    <name>Q2GXL3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Malate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224947.1">
        <property type="nucleotide sequence ID" value="XM_001224946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXL3"/>
    <dbReference type="GeneID" id="4394271"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07291"/>
    <dbReference type="eggNOG" id="ENOG502S85Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067863_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GXL3"/>
    <dbReference type="OMA" id="GQPPKTC"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021706">
        <property type="entry name" value="DUF2990"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567:SF1">
        <property type="entry name" value="CONSERVED FUNGAL PROTEIN (AFU_ORTHOLOGUE AFUA_1G14230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567">
        <property type="entry name" value="MALATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G13800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11693">
        <property type="entry name" value="DUF2990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208261" description="Malate dehydrogenase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="26095" checksum="BDB975CC51273BD7" modified="2006-03-21" version="1">MHASLLFVSALAASVWAAPTYPKIDAGASIPDNIRTVSEYFNMLASKVQDSRLLNSPPICDLSKVSLPAGAAGLPSPSPNLHLRHIAIGRGTQNYTCNPAEPNEAPKAAGALATLFNASCLVATSPHLANTLTRAALHFEVGQSAASEQLAPSNIGLSGVHFFTDATTALFKLDVAPALQIGELPCGKNASADAPTDAPKGLQGEGAVAWLKLIAKPGATGGLQEVFRVETVGGSAPATCNGLPNAFEVQYSTQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-03" modified="2025-06-18" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYA8</accession>
    <name>MAP22_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methionine aminopeptidase 2-2</fullName>
            <shortName evidence="1">MAP 2-2</shortName>
            <shortName evidence="1">MetAP 2-2</shortName>
            <ecNumber evidence="1">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">CHGG_07046</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="1">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="1"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224702.1">
        <property type="nucleotide sequence ID" value="XM_001224701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYA8"/>
    <dbReference type="SMR" id="Q2GYA8"/>
    <dbReference type="FunCoup" id="Q2GYA8">
        <property type="interactions" value="1051"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GYA8"/>
    <dbReference type="MEROPS" id="M24.002"/>
    <dbReference type="GeneID" id="4393147"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07046"/>
    <dbReference type="eggNOG" id="KOG2775">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_7_1_1"/>
    <dbReference type="InParanoid" id="Q2GYA8"/>
    <dbReference type="OMA" id="PFAKRWL"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
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    <sequence length="439" mass="48244" checksum="E1E54ED5023BDB67" modified="2006-03-21" version="1">MAAQAPPTDELSKLSVEDADNKPQPDASNGNLNHDEDDSEDDAEDASAPAAGGAKKKKKRKPRKKKKNPTQQSDPPRVLISQLFPDKQYPKGEEVEYLNENSYRTTNEEKRHLDNLKSEFLNDYRHAAEAHRQVRQWAAKNIKPGQSLTDIANGIEDSVRALVGHQGLEEGDALIAGMGFPTGLSINHCAAHYTPNAGNKMILQQDDVMKIDFGVQVNGNIVDSAFTMAFNPRYDPLLEAVKAATNAGIKEAGIDVRLGEIGGVIQEVMESYEVEIDGTTYPVKPIRNLNGHTILPYNIHGGKSVPIVKSNDTTKMEEGDVFAIETFGSTGGGHVIEDGEVSHYAKRTDAPKVDLRLSSAKSLLSVINKNFGTLPWCRRYLDRLGQEKYLLGLNNLVSNGIVEAYPPLVDKKGSYTAQFEHTILIRPTVKEVISRGDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYB4</accession>
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Untereiner W.A."/>
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    </dbReference>
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        </source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYD1</accession>
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        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 1</fullName>
        </recommendedName>
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        </alternativeName>
    </protein>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EAQ85770.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001224678.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019680">
        <property type="entry name" value="Mediator_Med1"/>
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        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041:SF4">
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    </dbReference>
    <dbReference type="Pfam" id="PF10744">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
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            <end position="530"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="591"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU364059"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ85770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="681" mass="74352" checksum="B394AC1148BE0FE1" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYQ1</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CHGG_06903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001224558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYQ1"/>
    <dbReference type="GeneID" id="4393535"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06903"/>
    <dbReference type="HOGENOM" id="CLU_783035_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYQ1"/>
    <dbReference type="OrthoDB" id="10407358at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="354" mass="38588" checksum="D74BB27A15E7BDD0" modified="2006-03-21" version="1">MPSRIWLHVFDKNRCACGVNTAGPVPNWELAESGHSPVNPSFFESLLSVSASHFRNFPAQCLVRVPCQVEIVGPKLLFQVLPQHLKISSTQRLLRVGNARPGCNHPNLENNRTEISTKRANFGARSRALGRAGMRSDIRRRKTPRFCAVMHQRRRMHVSPAACSQPDAKTVGRASATHMRPAAPVIFKSSSERAEGHNARPNPAPATQGPFLRGPQCHSHPAAPHGTSQVNSRRHALTGLQIHPPSLASLAAAATSEPRPSPSPKFSSHPSHRLVPLRGDIPQLRKYLFKPFALDIHHDWPSMLASMDQVTGGPQAGSGGSLAFPSPAPSTTRPRRGARVPPLWHARLTGQEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZ89</accession>
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            <fullName evidence="2">TRIP4/RQT4 C2HC5-type zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">CHGG_05157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ88538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224371.1">
        <property type="nucleotide sequence ID" value="XM_001224370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZ89"/>
    <dbReference type="STRING" id="306901.Q2GZ89"/>
    <dbReference type="GeneID" id="4392936"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05157"/>
    <dbReference type="eggNOG" id="KOG2845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027500_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GZ89"/>
    <dbReference type="OMA" id="MWASPQE"/>
    <dbReference type="OrthoDB" id="338816at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180022">
        <property type="term" value="C:RQC-trigger complex"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039128">
        <property type="entry name" value="TRIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009349">
        <property type="entry name" value="TRIP4/RQT4_C2HC5_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963">
        <property type="entry name" value="THYROID RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06221">
        <property type="entry name" value="zf-C2HC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="249"/>
            <end position="300"/>
        </location>
    </feature>
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        <location>
            <begin position="58"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="512"/>
        </location>
    </feature>
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        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="541" mass="57767" checksum="2EA80A136290D7CE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZG3</accession>
    <name>Q2GZG3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_05083</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001224296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZG3"/>
    <dbReference type="GeneID" id="4392307"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05083"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_306526_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZG3"/>
    <dbReference type="OrthoDB" id="4583287at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="672"/>
            <end position="755"/>
        </location>
    </feature>
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        <location>
            <begin position="498"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="807"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="156"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="813"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ88464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="966" mass="107824" checksum="98F2361EF90D120E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZN6</accession>
    <name>Q2GZN6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001224223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZN6"/>
    <dbReference type="STRING" id="306901.Q2GZN6"/>
    <dbReference type="GeneID" id="4391584"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05010"/>
    <dbReference type="eggNOG" id="KOG4778">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090382_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GZN6"/>
    <dbReference type="OMA" id="ERERNWM"/>
    <dbReference type="OrthoDB" id="2098203at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042831">
        <property type="entry name" value="Ribosomal_mL40_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39150">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39150:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="233" mass="26139" checksum="349B32424E33FAC1" modified="2006-03-21" version="1">MSFTIPSLRGLASRFLIRPTTLTATLSHPSKTTQCLAASARPLSTTPSTLAPPGAKGQKGPNKGPNRGGKPQAKTKKGGKGRGEEPRDPKMINMLSHFSILSPNRIPPPLRMGRNRHLRHWTIHRAWLLFRRREREARERNLMRQHQSMSAACEELRLTSGPGTRGEGYLYRMAMEKKGVYGLHGVPVEYARAQTETPARVAWNHDWKRPPPELSWQAGIKYVLHCQSEFAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZP1</accession>
    <name>Q2GZP1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224219.1">
        <property type="nucleotide sequence ID" value="XM_001224218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZP1"/>
    <dbReference type="GeneID" id="4391579"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05005"/>
    <dbReference type="HOGENOM" id="CLU_1156264_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZP1"/>
    <dbReference type="OrthoDB" id="10287854at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="240" mass="25900" checksum="09AC794D4E2F360F" modified="2006-03-21" version="1">MCRLHRNANREELGEQPNFNYQGLLFFPRALPSTQPSPWPVGAGATRTSTNGKWAGHNWCEAALLDGTSQLRKSDSKGPNRGPLETDESLGNLGLIISTVSRGSQSKRVDVTGCGGSCPPSGVFTAMQNSTKPVPGCGAGNYPVSSVDFVGSQRCSILRQSQRLPIPNLMVHRSLRRCLCHCLARPTHCATLAIHGSDGPKNQTSSAEDLQGTDIFRPRTCMPPANKQSETWPDHLQHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZR3</accession>
    <name>Q2GZR3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224197.1">
        <property type="nucleotide sequence ID" value="XM_001224196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZR3"/>
    <dbReference type="GeneID" id="4392025"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04983"/>
    <dbReference type="HOGENOM" id="CLU_1786624_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZR3"/>
    <dbReference type="OrthoDB" id="2105912at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910">
        <property type="entry name" value="TRANSPORTER SCO4007-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="145" mass="15927" checksum="1D3717BA88415FC3" modified="2006-03-21" version="1">MANEKTHQIPGPDQGLGSNPGPDDGQHEQETPQPRNKTDETPGGDIPPTASAIEDTAAPDIQEPTKRSALRRAWEWKPKPARYDPENPPKFTIWLNLLFAFAACFTVANLYYNQAILNRIAETFHVTFEKASSVATSCKPVTPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H016</accession>
    <name>Q2H016_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">V-type proton ATPase subunit F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_04880</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224094.1">
        <property type="nucleotide sequence ID" value="XM_001224093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H016"/>
    <dbReference type="FunCoup" id="Q2H016">
        <property type="interactions" value="622"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H016"/>
    <dbReference type="GeneID" id="4392946"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04880"/>
    <dbReference type="eggNOG" id="KOG3432">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135754_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H016"/>
    <dbReference type="OMA" id="ELNKNCH"/>
    <dbReference type="OrthoDB" id="10261947at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10580:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005772">
        <property type="entry name" value="ATPase_V1-cplx_fsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01101">
        <property type="entry name" value="V_ATP_synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861:SF2">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015945">
        <property type="entry name" value="ATPase_V1_F_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="AtpF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR015945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ88261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="124" mass="14103" checksum="565D988420C954E3" modified="2006-03-21" version="1">MASQADYRDRQFLAVIGDEASNLTYATRPALGHVTAPPDNQKNFLVVDAKTDTASIEAAFERFTTERKDIGIVLINQHIADRIRNRVDTYTQAFPTILEIPSKDHPYDPEKDSVLRRVRRLFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0B0</accession>
    <name>Q2H0B0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224000.1">
        <property type="nucleotide sequence ID" value="XM_001223999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0B0"/>
    <dbReference type="GeneID" id="4391678"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04786"/>
    <dbReference type="HOGENOM" id="CLU_1586275_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H0B0"/>
    <dbReference type="OrthoDB" id="10507919at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="168" mass="18144" checksum="B796941C9189F242" modified="2006-03-21" version="1">MWGGRQVTSDDSPADDQQRVWDGGGACQSSWQNLSQGGGVGEEGAGDQKPVRVHRQVNSSKPSSVQPSSSQPRFSFLPVTPDQGGSARVAYQADHSMTTSFARVLVSIINGRGLDLRNARMRPETAAIARRGAARWATCANPELRLASPGVVVCRLTSWRRESPQTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0H3</accession>
    <name>Q2H0H3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223937.1">
        <property type="nucleotide sequence ID" value="XM_001223936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0H3"/>
    <dbReference type="GeneID" id="4392884"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04723"/>
    <dbReference type="eggNOG" id="ENOG502T4XR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_613937_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H0H3"/>
    <dbReference type="OrthoDB" id="4588275at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="446" mass="47309" checksum="003A3DA9DC2E8DB7" modified="2006-03-21" version="1">MPEYASVTTTYRPDPTCFAPSNLWVGECAYEFTTANLEPTTILTAIDGTTYPMTYPTMASYCKAASVKQLSGSKVTLNVQASPTPTTTEVDWDYDNDFLVVTAALIQKYLYTGKPGTTSTCFGDSHCVMNSNPIKPHPTHAPYGTYFPPPSSAVTQFTPAASCLASSNLWLVSDRCSLTTDPRTPPWLQCTHTVAGDPDPTRADCYPVGLSTVVTGTPTYYTDCPAGYTTVNTTVYFPWTVANGGPAYDKAKGTQLTCCPAPFRGLTFEHRSPQWTYSTVYDGTTHTVSSRTLPPYCAAYGGNMRGGDGEMLTLGLYSNGIEGRPGSTYDGVSEATWDGAWGTLYAHAHTLSWTVFHATHTCFEPAECREYFTYSYGNTLGPGVVVATPTPTRDSEGGGSEAASSSSTAAAAALVPVRGDGRAGLAGVVVVVVTVVVNVVLGAGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1L4</accession>
    <name>Q2H1L4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223546.1">
        <property type="nucleotide sequence ID" value="XM_001223545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1L4"/>
    <dbReference type="STRING" id="306901.Q2H1L4"/>
    <dbReference type="GeneID" id="4391671"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04332"/>
    <dbReference type="eggNOG" id="KOG0922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_915271_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H1L4"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="304" mass="33970" checksum="C916700F53671B85" modified="2006-03-21" version="1">MGDILLFLTGQEEIDTASPPGSRKVVIATNIAETSITIDYIYYVIDPGFVKQNAYDPKLGMDSLVVTPVSQAQANQRAGRAGRTGPGKKAGASGPEESQVHDPSGDHLTLLNVYTSWKNNGFANAWCFENFIQARSMRRAKDVRDQIVKIMERHRHPIISCGRDTDKIRRSLCSGFFRNTARKDPQEGYKTLIEGTPVYLHPSSALFGKQAEWVVYHTLVLTTREYMHFTTTIEPKWLADEAPTFFKVAPTDRLSKRKQAERIQPLYNKYATEDDWRLSAQRRAGRSGGGGGTWAKSVGLSGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H257</accession>
    <name>Q2H257_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223353.1">
        <property type="nucleotide sequence ID" value="XM_001223352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H257"/>
    <dbReference type="GeneID" id="4391712"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04139"/>
    <dbReference type="eggNOG" id="ENOG502S808">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001248_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H257"/>
    <dbReference type="OrthoDB" id="3934771at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="45210" checksum="A597E39B31AF7F4A" modified="2006-03-21" version="1">MVIDECWENLLFLIGSGEGYRPFGGIPIVLFFGDFFQFDPVLQTSLLLPAPRDRGGQRPESLPKHLAAHRLFLQFTTVVILQEQVRAAGCPRLRGFLGRLRNGEQTELDFQRLSQRLYTPSCKASFVDGLRAITPLNQDRWDLNMAAVVQWARACGKHISIFVAKHDTESGKRLRVEELGDVLRRGDDSQLPTPGLFFYAQGMPVMVTQNQFIGLKVVNGAPFKAVDIFPDPAAGTIALASDVTLQLGPPVAVLLQSDDGADLAIPGLPNGTILIKSNTVAIPTQMRAKEGASRAFGGLPTELDSLHTGLRYDRSEEPRQAVLGRPRQSQRRPLGRHGDSTQLHEPGGHPQAGTTGRGDQTAVRARPQVSDLRSEPWFQEWAAMPESGQGTETDDVEDAALWRDPGVSEPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H272</accession>
    <name>Q2H272_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="2">4.3.3.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_04124</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="2"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223338.1">
        <property type="nucleotide sequence ID" value="XM_001223337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H272"/>
    <dbReference type="STRING" id="306901.Q2H272"/>
    <dbReference type="GeneID" id="4391976"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04124"/>
    <dbReference type="eggNOG" id="KOG1606">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176854_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H272"/>
    <dbReference type="OrthoDB" id="1660966at2759"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ87505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="74" mass="7941" checksum="2182A98D6A5143A2" modified="2006-03-21" version="1">MHLGCDGVFVGSGIFKDAETPEHAAKRARAIVKATTQFTDKKALIEASIEHGEAMRGISNAGLKPEEKMSGRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2G0</accession>
    <name>Q2H2G0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223250.1">
        <property type="nucleotide sequence ID" value="XM_001223249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2G0"/>
    <dbReference type="GeneID" id="4392392"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04036"/>
    <dbReference type="HOGENOM" id="CLU_2978938_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2G0"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="58" mass="6269" checksum="05589193004C415A" modified="2006-03-21" version="1">MGSRGAAASCDVILSRSRGQSHTQDCDTPLSSQEADYHDREADKSQEITSSNQDTNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2W8</accession>
    <name>Q2H2W8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Intradiol ring-cleavage dioxygenases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_03878</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223092.1">
        <property type="nucleotide sequence ID" value="XM_001223091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2W8"/>
    <dbReference type="GeneID" id="4391900"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03878"/>
    <dbReference type="eggNOG" id="ENOG502QPRK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027719_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H2W8"/>
    <dbReference type="OMA" id="FAGQNSC"/>
    <dbReference type="OrthoDB" id="121380at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03457">
        <property type="entry name" value="intradiol_dioxygenase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF1">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209230" description="Intradiol ring-cleavage dioxygenases domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="3">
        <location>
            <begin position="122"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ87259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="411" mass="42946" checksum="475891527470D46B" modified="2006-03-21" version="1">MHFTKAISGLAALASLVTAHPGHDVAQEAAERRSYLQSVKRTSLAHCADKLKARGTSARNVARRQAVVEKARRKRGLKKRDFDAVLGTDHNKTALGYTRNTDAATLFSGYKSCLLTPEVTQGPYYVAGEYVREDVVEDQAGVPLLLDYQVIDIDSCEPIPEVYLEIWHCNATGVYGGVVANGNGDSSDASNLDNTFLRGIQATNADGVAQFESVFPGHYTGRTPHIHVMVHTNATLQANETLGLDNYASHVGQTFFDQTLISAVEAVEPYASNTQPLTTNAQDGIMAQEAGTEGVDPVMEYTLLGDSIEDGLFAWIAFGIDSSRSEAINPAVYYGEGGGVANPSGGFGGPGGPGGPGGSPTGSPPPAETATPTTAAAADETAAPTTSAAAADESAAPGKGCGRGINRGQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H358</accession>
    <name>Q2H358_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_03788</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223002.1">
        <property type="nucleotide sequence ID" value="XM_001223001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H358"/>
    <dbReference type="STRING" id="306901.Q2H358"/>
    <dbReference type="GeneID" id="4391524"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03788"/>
    <dbReference type="eggNOG" id="KOG2495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021377_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H358"/>
    <dbReference type="OMA" id="HVDVLTN"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.100:FF:000002">
        <property type="entry name" value="External alternative NAD(P)H-ubiquinone oxidoreductase B1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.100:FF:000005">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 64 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF50">
        <property type="entry name" value="NADH DEHYDROGENASE (UBIQUINONE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="502"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ87169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="656" mass="73237" checksum="4ED73B8DBAF0DDB6" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3B8</accession>
    <name>Q2H3B8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_03728</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222942.1">
        <property type="nucleotide sequence ID" value="XM_001222941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3B8"/>
    <dbReference type="STRING" id="306901.Q2H3B8"/>
    <dbReference type="GeneID" id="4391728"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03728"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_14_0_1"/>
    <dbReference type="InParanoid" id="Q2H3B8"/>
    <dbReference type="OMA" id="DSREHWE"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="97"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ87109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28628" checksum="8892D7EF3FC09765" modified="2006-03-21" version="1">MTTKTNITAYSEGTPNGLKVHIALEELGLEYKLVQIDIFKNEHKEPWFTEINPNGRIPAIIDVTADGLELKIFESGAILEYLVATYDKNHLISYPRGTKEHWETISWLMWQMGGLGPMLGQSNFFARSAVGVHQYSIDRYVNESRRLLRVLDGHLEKKGTAFLVGDRLTIADIAIWPWVSATRYSGLRAIEEFPNVSKWFWGLLERPGFQKGANIPGPNKYLATNKMTEEEMNKAAAPTVKWIAESMKRDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3J7</accession>
    <name>Q2H3J7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222863.1">
        <property type="nucleotide sequence ID" value="XM_001222862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3J7"/>
    <dbReference type="STRING" id="306901.Q2H3J7"/>
    <dbReference type="GeneID" id="4390050"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06768"/>
    <dbReference type="eggNOG" id="ENOG502SINF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_339788_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3J7"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="836" mass="89086" checksum="B4A80EEA30E1F87F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3N3</accession>
    <name>Q2H3N3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glycine dehydrogenase (aminomethyl-transferring)</fullName>
            <ecNumber evidence="2">1.4.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glycine cleavage system P protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_06732</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="2"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222827.1">
        <property type="nucleotide sequence ID" value="XM_001222826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3N3"/>
    <dbReference type="FunCoup" id="Q2H3N3">
        <property type="interactions" value="613"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H3N3"/>
    <dbReference type="GeneID" id="4390972"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06732"/>
    <dbReference type="eggNOG" id="KOG2040">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004620_3_2_1"/>
    <dbReference type="InParanoid" id="Q2H3N3"/>
    <dbReference type="OMA" id="RNLICTC"/>
    <dbReference type="OrthoDB" id="6537869at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="7">
        <location>
            <begin position="9"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="8">
        <location>
            <begin position="718"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00082072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ90113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="894" mass="97518" checksum="0F3EF47FBCE69110" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3P1</accession>
    <name>Q2H3P1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_06724</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>propanoyl-CoA + oxaloacetate + H2O = (2S,3S)-2-methylcitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58853"/>
            <dbReference type="EC" id="2.3.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222819.1">
        <property type="nucleotide sequence ID" value="XM_001222818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3P1"/>
    <dbReference type="STRING" id="306901.Q2H3P1"/>
    <dbReference type="GeneID" id="4391071"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06724"/>
    <dbReference type="eggNOG" id="KOG2617">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022049_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H3P1"/>
    <dbReference type="OMA" id="IDHGFNA"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050440">
        <property type="term" value="F:2-methylcitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019629">
        <property type="term" value="P:propionate catabolic process, 2-methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF15">
        <property type="entry name" value="CITRATE SYNTHASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ90105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="442" mass="48722" checksum="66C21B0D2C467399" modified="2006-03-21" version="1">MAMSLRTGRHALSGALRPMIVTSHSYLAPRRTYATAEPDLKTTLKEVIPAKRELLKKVKAHGAKVIGEVKVENTIGGMRGLKAMVWEGSVLDANEGIRFHGRTIKDCQKELPKGKTGTEMLPEAMFWLLLTGKVPSVNQFAMAVSALNYTSKFAKAYEQGLNKADYWEPTFDDCISLLAKLPTIAAKIYQNAYRGGGALPAEIDLEQDWSYNFAAMLGKGGRENENFQDLLRLYLALHGDHEGGNVSAHTTHLVGSALSDPFLSYSAGLQGLAGPLHGLAAQEVLRWIIQMKDAIPASYTEKDVHDYLWTTLNSGRVVPGYGHAVLRKPDPRFEALMDYAAARPEIANDPVFQLVRTNSQIAPEVLKKHGKTKNPYPNVDSSSGVLFHHYGFHETLYYTATFGVSRGLGPLAQLVWDRALGLPIERPKSINLEGLLKEVEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4U3</accession>
    <name>Q2H4U3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_06322</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222417.1">
        <property type="nucleotide sequence ID" value="XM_001222416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4U3"/>
    <dbReference type="SMR" id="Q2H4U3"/>
    <dbReference type="GeneID" id="4390590"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06322"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_9_3_1"/>
    <dbReference type="InParanoid" id="Q2H4U3"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="638"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="8">
        <location>
            <begin position="221"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="555"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="555"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="605"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ89703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="658" mass="69958" checksum="0D4A4E9494BC4610" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4W8</accession>
    <name>Q2H4W8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_06297</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222392.1">
        <property type="nucleotide sequence ID" value="XM_001222391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4W8"/>
    <dbReference type="STRING" id="306901.Q2H4W8"/>
    <dbReference type="GeneID" id="4390730"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06297"/>
    <dbReference type="eggNOG" id="KOG1613">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1309973_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4W8"/>
    <dbReference type="OMA" id="TITCELV"/>
    <dbReference type="OrthoDB" id="45882at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF9">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="11">
        <location>
            <begin position="46"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ89678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="210" mass="23049" checksum="7DF0CF313607E93D" modified="2006-03-21" version="1">MTAPTIKLPAPLFARLSPHPFLLRNLTSAADPSRPATRTNGRGTQETRPLHAKTSSLSHAHGSSLVRLGDTTVLCGVRGELLPVERVPLWDPEREMVVCSRTEKRQLNVKGLPVACTAAVFEEKELGEVGTGVAEGRHWLLLDPDRLEETLCREAITMVVDCSDGETRIKSIEKQGGTAIGRELVRGFATIAEKRWKEVQGSYEVRTVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5I8</accession>
    <name>Q2H5I8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_06077</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222172.1">
        <property type="nucleotide sequence ID" value="XM_001222171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5I8"/>
    <dbReference type="STRING" id="306901.Q2H5I8"/>
    <dbReference type="GeneID" id="4391280"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06077"/>
    <dbReference type="eggNOG" id="ENOG502QQ0P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030515_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H5I8"/>
    <dbReference type="OMA" id="HARTFNY"/>
    <dbReference type="OrthoDB" id="10263073at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20305">
        <property type="entry name" value="cupin_OxDC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20304">
        <property type="entry name" value="cupin_OxDC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF9">
        <property type="entry name" value="SLL1358 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209293" description="Cupin type-1 domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="6">
        <location>
            <begin position="96"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="6">
        <location>
            <begin position="268"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ89458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="432" mass="48412" checksum="5C120338C7A126B8" modified="2006-03-21" version="1">MRLSSSALLLAAGLSDLATAVPIQDSPRQRLLDGKPLPAKYRKATPAPNPYTPDYRDPYDKSVDSIGEGLDPLPWRNGEGASVLGPWNRERSRQNPDLEGGWTRQTTVRELPTSVELAAVNMRLGEGVIRELHWHKEAEWAYVLDGSVRVTALDYEGGTFVDDLQKGDLWYFPSGVPHSLQGLSANGTEFLLIFDSGSFSEESTFLLTDWLAHTPRSVISKNFHLPPEVFAHIPPSERYIFQGSQPGSVDDEFPKGKYVKPSTQQFTHRMLAQEPKNTTGGEVRIADTRNFNVSKTVAAAHVLIRPGALREMHWHPNADEWSFFLRGRARVTVFGAEGTARTFDYQPGDVGIVPRNMGHFVENIGDEDIEMLEVFRADEFRDFSLFQWLGETPRRMVADTLFKGDKEAGEKFLKEIEDAGKDEVTLPLNDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5Q3</accession>
    <name>Q2H5Q3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222107.1">
        <property type="nucleotide sequence ID" value="XM_001222106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5Q3"/>
    <dbReference type="GeneID" id="4390530"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06012"/>
    <dbReference type="HOGENOM" id="CLU_2014993_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5Q3"/>
    <dbReference type="OrthoDB" id="10387312at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="123" mass="12770" checksum="7D14848756537A01" modified="2006-03-21" version="1">MSSSHPENNPDNENSNPQTPNPPAAEASHPSDDSGETRPKGGHGPTKDQLEAAWTALARLEAIGVIKPFVVRYPRIIDVDGTVLSEGTMTGHDSGVEAAVGSLTEGATPSGESESKAGREARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H668</accession>
    <name>Q2H668_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Methylenetetrahydrofolate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="12">1.5.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_05847</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes oxidation of cytoplasmic one-carbon units for purine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.15" evidence="12"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221942.1">
        <property type="nucleotide sequence ID" value="XM_001221941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H668"/>
    <dbReference type="FunCoup" id="Q2H668">
        <property type="interactions" value="239"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H668"/>
    <dbReference type="GeneID" id="4390905"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05847"/>
    <dbReference type="eggNOG" id="KOG0089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031413_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H668"/>
    <dbReference type="OMA" id="CKVITAE"/>
    <dbReference type="OrthoDB" id="41403at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004487">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01079">
        <property type="entry name" value="NAD_bind_m-THF_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000255">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000012">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035812">
        <property type="entry name" value="m-THF_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="14">
        <location>
            <begin position="15"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="15">
        <location>
            <begin position="155"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAQ89228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="329" mass="36227" checksum="86DB7A45E4B7C0D7" modified="2006-03-21" version="1">MASQEVPKTCRVILADTIAKKLLAEVKETLASFQGTAASKPTLAAFLANDDPSAQQYADWSKKTCEENGFNFDLRKVDKEALEEAVVAANNDDAVDGMLVYYPIWRSNQQQDRYIQETVALSKDVEGLCHTHLFNMYHNTRFLDPPTNQKKSILPCTPLAIVKTLEHLQIYNPILAYGNRLFGKTVTVINRSEVNGRPLAALLANDGATVYSVDITGVQVFTRGSGIRAPRHQVHDKEGWTLENVLPLSDVVISGVPSEAFKVPTELIRDGAVCINFSSYRNFDGPAVKEKASIYVPSTGKVTIAVLLRNLMRLVANRHEAGAPSDVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6N4</accession>
    <name>Q2H6N4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_05681</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221776.1">
        <property type="nucleotide sequence ID" value="XM_001221775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6N4"/>
    <dbReference type="STRING" id="306901.Q2H6N4"/>
    <dbReference type="GeneID" id="4390367"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05681"/>
    <dbReference type="eggNOG" id="KOG0340">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H6N4"/>
    <dbReference type="OMA" id="RDWHRWE"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="324"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ89062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="512" mass="57097" checksum="7C4CB81D939035CC" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6S4</accession>
    <name>Q2H6S4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_05641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221736.1">
        <property type="nucleotide sequence ID" value="XM_001221735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6S4"/>
    <dbReference type="GeneID" id="4389977"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05641"/>
    <dbReference type="HOGENOM" id="CLU_863317_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6S4"/>
    <dbReference type="OrthoDB" id="4573675at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="322" mass="35367" checksum="116C55EC42E917E7" modified="2006-03-21" version="1">MAVGQRASFCVATNYSHGVDVARCVPPNEHEWWDRNLMDRYGRSSMLPFSTQSQDSPANLVPLRSAFHRVFDERHLCFAPKVVDGSDFDDCRRERSASACYLLPASPEPNPPPDPRSLSHLPTVQVAGLWHNRGLHAFPPGLSKECLFARFAYTILSPAVFSSTFLSGTRVSRCLRVWEPVVQITNTKILGSADCRRIARTVWSRHSGDGDEGGCEVEGGLLAQFDPDPAYATNGDEEERGRGPNSRVLSVLSLPLATELTDHCRAIVILIGDLYLVLSVLSLGLVTELTDHLDHLPGSLIGPFNDCLGASRDPRSLLLAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6W3</accession>
    <name>Q2H6W3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoporin NUP188</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_05602</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Nup188 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221697.1">
        <property type="nucleotide sequence ID" value="XM_001221696.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2H6W3">
        <property type="interactions" value="111"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H6W3"/>
    <dbReference type="GeneID" id="4390498"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05602"/>
    <dbReference type="eggNOG" id="ENOG502QQFV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001029_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6W3"/>
    <dbReference type="OMA" id="HSWKFFA"/>
    <dbReference type="OrthoDB" id="102511at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018864">
        <property type="entry name" value="Nucleoporin_Nup188_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044840">
        <property type="entry name" value="Nup188"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041634">
        <property type="entry name" value="Nup188_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048883">
        <property type="entry name" value="Nup188_N-subdom_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431">
        <property type="entry name" value="NUCLEOPORIN NUP188 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18378">
        <property type="entry name" value="Nup188_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10487">
        <property type="entry name" value="Nup188_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21093">
        <property type="entry name" value="Nup188_N-subdom_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21094">
        <property type="entry name" value="Nup188_SH3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal" evidence="10">
        <location>
            <begin position="197"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal subdomain III" evidence="12">
        <location>
            <begin position="732"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear pore protein Nup188 C-terminal" evidence="11">
        <location>
            <begin position="1365"/>
            <end position="1681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ88983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1701" mass="185899" checksum="045342FF54CC3BE3" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6Z6</accession>
    <name>Q2H6Z6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pentatricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_05569</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221664.1">
        <property type="nucleotide sequence ID" value="XM_001221663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6Z6"/>
    <dbReference type="STRING" id="306901.Q2H6Z6"/>
    <dbReference type="GeneID" id="4389961"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05569"/>
    <dbReference type="eggNOG" id="ENOG502QQWX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014304_3_0_1"/>
    <dbReference type="InParanoid" id="Q2H6Z6"/>
    <dbReference type="OMA" id="CVRDNIN"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936:SF1">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN GUN1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936">
        <property type="entry name" value="PPR_LONG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="258"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ88950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="602" mass="67350" checksum="8FC59D03395A23DA" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H780</accession>
    <name>Q2H780_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_05485</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221580.1">
        <property type="nucleotide sequence ID" value="XM_001221579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H780"/>
    <dbReference type="STRING" id="306901.Q2H780"/>
    <dbReference type="GeneID" id="4390025"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05485"/>
    <dbReference type="eggNOG" id="ENOG502QQNB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033094_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H780"/>
    <dbReference type="OMA" id="DTVFVPW"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021863">
        <property type="entry name" value="FAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11960">
        <property type="entry name" value="DUF3474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase N-terminal" evidence="8">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="7">
        <location>
            <begin position="87"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ88866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="45840" checksum="2AECA2C3953D62BC" modified="2006-03-21" version="1">MATTTTTTTRSRRAASEVKSAPIKLVEGPQYPDIQTIRDAIPAHCFVPSTWRSLGYVFRDVSMAAALGWAAFTYISQIEDFTWRTAVWIVYGYLQGLVCTGIWILAHEAGHGAFSVHQKLNDVVGWTLHSALLVPYFSWKFSHHRHHRFTGHMEKDMAFVPHTKADREKRRLADLYLDRELFEDIPVVQLFKLLAHQLAGWQMYLLFNVSAGSDSQQSKASWWRVSHFEPTSAVFRPSEALYVAITDIGLLIVAGLLYLASTVVGWKMVFLMYGVPYFWVHHWLVAITYLHHTHPDVHHFEADSWTFVKGALATVDRDFGFVGRHLFHGIIDTHVIHHLFPRIPFYKAEEATEAIKPLLGDLYHREERSFMGQLWSTFTQCKYVEADPAAPGALKWAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7K2</accession>
    <name>Q2H7K2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221458.1">
        <property type="nucleotide sequence ID" value="XM_001221457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7K2"/>
    <dbReference type="GeneID" id="4390428"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05363"/>
    <dbReference type="eggNOG" id="ENOG502SF2G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096170_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7K2"/>
    <dbReference type="OMA" id="HPIARNK"/>
    <dbReference type="OrthoDB" id="5388322at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027911">
        <property type="entry name" value="DUF4604"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15377">
        <property type="entry name" value="DUF4604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4604" evidence="2">
        <location>
            <begin position="8"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="186" mass="19563" checksum="CE45A9F5FDB62C48" modified="2006-03-21" version="1">MSQKISAKNLQYNTTLPPFLARLRGENPSGADRDGPDPILAGRRRAVKPRSGSAEAEDAPLVVDDQGNAVDVTVGADGSVKEKESAEKPQDASPGEGTLATEASAKVGEKLADIGGQRKKRKIGKIIGAETEEDDPEDKHGKSDKSSRPKAGNALAAEKEDPTVVAKPKPKKKAKKVKLSFGDDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H886</accession>
    <name>Q2H886_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_03568</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230084.1">
        <property type="nucleotide sequence ID" value="XM_001230083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H886"/>
    <dbReference type="GeneID" id="4388746"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03568"/>
    <dbReference type="HOGENOM" id="CLU_029216_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H886"/>
    <dbReference type="OMA" id="CETREDG"/>
    <dbReference type="OrthoDB" id="3727384at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032382">
        <property type="entry name" value="AltA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16541">
        <property type="entry name" value="AltA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209058" description="AA1-like domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="AA1-like" evidence="6">
        <location>
            <begin position="51"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ91633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="541" mass="59196" checksum="48FF72F9B1F98880" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8E7</accession>
    <name>Q2H8E7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Succinate/fumarate mitochondrial transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_03507</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230023.1">
        <property type="nucleotide sequence ID" value="XM_001230022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8E7"/>
    <dbReference type="FunCoup" id="Q2H8E7">
        <property type="interactions" value="317"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H8E7"/>
    <dbReference type="GeneID" id="4388708"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03507"/>
    <dbReference type="eggNOG" id="KOG0756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_5_0_1"/>
    <dbReference type="InParanoid" id="Q2H8E7"/>
    <dbReference type="OMA" id="KDWYKGG"/>
    <dbReference type="OrthoDB" id="204711at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005469">
        <property type="term" value="F:succinate:fumarate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000021">
        <property type="entry name" value="SFC1p Mitochondrial succinate-fumarate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF2">
        <property type="entry name" value="SUCCINATE_FUMARATE MITOCHONDRIAL TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="24"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="126"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="230"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ91572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="35656" checksum="4AAF2E98D8E5C42A" modified="2006-03-21" version="1">MATKVGKDGKKPASAATNLIGEPQPMAASPARVLVCPILTRRVDSQLAEVLVRMQLSRRGREPGMPKRGFIATGLEIVRKETPLGLYKGLGAVLTGIVPKMAIRFTSFEWYKQVLAHKDTGVVSGQSLFLAGLAAGVTEAVAVVTPMEVVKIRLQAQHHSMADPLDIPKYRNAAHALYTIVKEEGAGALYRGVSLTALRQGSNQAVNFTAYTYFKEWLYQWQPEYRGASLPSYQTTLIGLVSGAMGPLSNAPIDTIKTRLQKMRAEEGTSALQRITRIAGDMFKCGITPRIMRVAPGQAVTFTVYEYLKEKLEKSGPAVLTGGRYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8F4</accession>
    <name>Q2H8F4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_03500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230016.1">
        <property type="nucleotide sequence ID" value="XM_001230015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8F4"/>
    <dbReference type="GeneID" id="4389008"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03500"/>
    <dbReference type="eggNOG" id="ENOG502RJZ9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_475016_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8F4"/>
    <dbReference type="OMA" id="NIETIRC"/>
    <dbReference type="OrthoDB" id="5210863at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ91565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="63868" checksum="59386138BCD5D91E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8K2</accession>
    <name>Q2H8K2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucanase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_03452</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229968.1">
        <property type="nucleotide sequence ID" value="XM_001229967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8K2"/>
    <dbReference type="STRING" id="306901.Q2H8K2"/>
    <dbReference type="GeneID" id="4389811"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03452"/>
    <dbReference type="eggNOG" id="ENOG502RWSR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020817_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H8K2"/>
    <dbReference type="OMA" id="FSIWNDN"/>
    <dbReference type="OrthoDB" id="412382at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF1">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE CELB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209351" description="Glucanase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ91517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="399" mass="42189" checksum="377A620EA7B63FB5" modified="2006-03-21" version="1">MIGSRTLQGLVATALATLPLVNGQQPGSVTPEVHPKLPTWQCTKSGGCVEQDTSVVLDWNYRWFHTSDNTTSCTTSSGIDSTLCPDAATCAENCVVEGTDYTSSGIETSGSSLTLRQFVKDSEGKTNSVSPRAYLLGADGDYVMFKLLNQELSFDVDVSTLPCGENAALYFSEMDKTGGRNEHNTGGAKYGSGYCDAQCPVQTWNNGTLNTSHQGSCCNEMDILEANSKAEAFTPHPCIGDNCDKGGCGFNSYARGNKNYWAPGGTLDTSKPFTMVTQFITDDGTSSGKLSQIVRSYVQNGQKVASAVSGGDSITVEGCSSSDAYGGLVGMGEALGRGMVLAMSIWNDASGFMNWLDSGDNGPCNETEGDPANILANHPDSQVVLSNIRWGDIDSTVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8P1</accession>
    <name>Q2H8P1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229929.1">
        <property type="nucleotide sequence ID" value="XM_001229928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8P1"/>
    <dbReference type="GeneID" id="4389767"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03413"/>
    <dbReference type="eggNOG" id="ENOG502RJEA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1503275_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8P1"/>
    <dbReference type="OMA" id="GANDQHL"/>
    <dbReference type="OrthoDB" id="4588907at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="179" mass="19740" checksum="915758819A4B4C4A" modified="2006-03-21" version="1">MDFAMQIDSSRKRCRDEPELHGANDQHLAKRARQWDMDASTRDSTPSLGESTPSTPASIDVDMEDTPQQAPTQAPKPAPEPFQSGGGMIISGWNQNRRDQYLRQGYPLAWMQSSTQSQRLPTHQSRNDKPVRPFPAPSAASASRKVLPPKSVASTRVTLSWSTSIEIFLVWAGPGGLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9K4</accession>
    <name>Q2H9K4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229616.1">
        <property type="nucleotide sequence ID" value="XM_001229615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9K4"/>
    <dbReference type="STRING" id="306901.Q2H9K4"/>
    <dbReference type="GeneID" id="4388891"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03100"/>
    <dbReference type="eggNOG" id="ENOG502S564">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052686_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9K4"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46504">
        <property type="entry name" value="TRNASE Z TRZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46504:SF2">
        <property type="entry name" value="TRNASE Z TRZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="59"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="334" mass="36293" checksum="082C5DB4B150D0E9" modified="2006-03-21" version="1">MPPPTFATPLPQSPRSDILEWRFPKPYHNLTLTGRSRAAWHTSFVIPQLNLLLDAGMVVNNLRPKHIFLTHGHSDHTLLTPAFVKRSDPPDIYCPAEMKDALDNFINAKTMLSEGGGIWPPESTSPYLKKYKLDNTSNTSETKTKEEVEPADNQQNPAREQDQEQEQAQDESQNQPPNPDPPSISTPNPPPQPPSSPPHPLSKRTPSTGLHPSSTITLPAPSRPSNPTRPTGLPLRAHTVPCLGYLFSSRHPQAQARVVRGLSGAQLKALRQQQQQQQGGNEDDEGAVKGRGVVELTAPVATPACLRCPGGYHGGYARGGAGVVRRGAGGDHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9L8</accession>
    <name>Q2H9L8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229602.1">
        <property type="nucleotide sequence ID" value="XM_001229601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9L8"/>
    <dbReference type="STRING" id="306901.Q2H9L8"/>
    <dbReference type="GeneID" id="4389351"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03086"/>
    <dbReference type="eggNOG" id="ENOG502S38Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023951_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H9L8"/>
    <dbReference type="OMA" id="IQMQTYR"/>
    <dbReference type="OrthoDB" id="4181307at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034443">
        <property type="entry name" value="PB1A10.08"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42051">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED PROTEIN PB1A10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42051:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED PROTEIN PB1A10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="472" mass="51975" checksum="BEE143BBD7B52FBC" modified="2006-03-21" version="1">MSAALQRPGEDGFGSRTPGTPRPEMMPTRATTTSTPVQIPTRPKSRDPTHPAHTQKPHRNHGGRRNHSMARSRDAHSRDAIPPSVAALLAITSIPPPKAARSLRQTKTEKRMTVESIIERAQESEKELSLTLSKSPLDILLMAPEDLEADDTSVCDSIPESVLSTRTISMESMPSLSNSFTTDNTFSSLESPHTPLRRRNIQPTRRSMEPVSSPPGEPENHPLSSPEDEIADLDLSVFSGKEEAPDKKTSRLPFSPLKSAFKSNLTASLRALRQAARSFSNLNFSSIPPEDFLTRSILTIDPQVPYTDERRPPPLEEEPTAALRRYLNPTTTARMEKPAPVASGPALRTFTASIQMQTYKIQRARSPSSNSGRSPYPSIGPSSTSTAAASQPPQPKPVVTEHPMPGPRQREMRENPDFIRIAVMEMAMRKSGKLDDQRPGRARWALPPRKSNTSPYEIGPDGVPARWVAVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9M7</accession>
    <name>Q2H9M7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229593.1">
        <property type="nucleotide sequence ID" value="XM_001229592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9M7"/>
    <dbReference type="STRING" id="306901.Q2H9M7"/>
    <dbReference type="GeneID" id="4389060"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03077"/>
    <dbReference type="eggNOG" id="ENOG502SHVS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026450_5_0_1"/>
    <dbReference type="InParanoid" id="Q2H9M7"/>
    <dbReference type="OMA" id="AFIWQSV"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF64">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="293" mass="32262" checksum="5AB5985F32DF6517" modified="2006-03-21" version="1">MLDRVCRGEEIPEAEVEVANRERDGVIPDLGDDEEEPREQLGRQTVKMSPAADMNATQHDEEVEQVASPAVWASFSFSGQSLAALKAAALETATSKRISTDDTLTAFIFQSITRARYHRLRDDPSATCTLGRAVDARRYLKIPATYPGLLNNMVFHSHSIQETISTPLGVLASELRHEVDPATSRIGLYTRALAALLHRTPGKGSISMGANINLSRDIMISSWAGAGADCYEMDFGMELGVPAAVRRPVFVPVEGLGYLLPKHPSGEIPLVICLREEDMELLKGDEEWRRWMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9W5</accession>
    <name>Q2H9W5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-binding protein VTS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">RNA-binding protein vts1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_02989</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA-binding protein involved in post-transcriptional regulation through transcript degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229505.1">
        <property type="nucleotide sequence ID" value="XM_001229504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9W5"/>
    <dbReference type="STRING" id="306901.Q2H9W5"/>
    <dbReference type="GeneID" id="4388902"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02989"/>
    <dbReference type="eggNOG" id="KOG3791">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017632_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9W5"/>
    <dbReference type="OMA" id="MSTVNNR"/>
    <dbReference type="OrthoDB" id="2155283at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09556">
        <property type="entry name" value="SAM_VTS1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000033">
        <property type="entry name" value="Protein vts1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057327">
        <property type="entry name" value="Vts1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037635">
        <property type="entry name" value="VTS1_SAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25479">
        <property type="entry name" value="Vts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SAM" evidence="14">
        <location>
            <begin position="538"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="228"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="503"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="503"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ91054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="606" mass="65343" checksum="32DC4734A72340A0" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9W9</accession>
    <name>Q2H9W9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_02985</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229501.1">
        <property type="nucleotide sequence ID" value="XM_001229500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9W9"/>
    <dbReference type="FunCoup" id="Q2H9W9">
        <property type="interactions" value="469"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H9W9"/>
    <dbReference type="GeneID" id="4388945"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02985"/>
    <dbReference type="eggNOG" id="KOG2360">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_7_4_1"/>
    <dbReference type="InParanoid" id="Q2H9W9"/>
    <dbReference type="OMA" id="IAKEELX"/>
    <dbReference type="OrthoDB" id="435282at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1170:FF:000006">
        <property type="entry name" value="NOL1/NOP2/Sun domain family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049561">
        <property type="entry name" value="NSUN5_7_fdxn-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048889">
        <property type="entry name" value="NSUN5_RCM1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF4">
        <property type="entry name" value="28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21148">
        <property type="entry name" value="NSUN5_fdxn-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21153">
        <property type="entry name" value="NSUN5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="6">
        <location>
            <begin position="131"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="239"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ91050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="330" mass="35482" checksum="01E260552844C242" modified="2006-03-21" version="1">MSLYHETAAIVTGPSTHGGSLKSRIYGNKDLKSPPAQVYALAFESSKWSAVLKEVVENSQLLQKERKSQITPTLSILLAHDLLLAKKGIALPASHGLRVSIEKHKARLQSEFTRARLRRKCPTVDALKAVIDAQSGPAHPRWIRVNSLKSTVDEQLDTTFKGFEVVPTVSEVMAPTSSNKKVLCLDSHVPNLIAAPPGIDFTKTPAYQSGAIILQDKASCFPAYLLDPRPEDGDIVDACSAPGNKTTHLAAILHERGGLAAGQQRILAFEKDKNRAKTLAKMVRAAGSDKVTVIHPGADFLKTDPDAPEFRAVGALLLDPSCSGSGDCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAA2</accession>
    <name>Q2HAA2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_02852</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="5"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229368.1">
        <property type="nucleotide sequence ID" value="XM_001229367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAA2"/>
    <dbReference type="FunCoup" id="Q2HAA2">
        <property type="interactions" value="736"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HAA2"/>
    <dbReference type="GeneID" id="4389374"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02852"/>
    <dbReference type="eggNOG" id="KOG0786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_3_1"/>
    <dbReference type="InParanoid" id="Q2HAA2"/>
    <dbReference type="OMA" id="LWRETVQ"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF1">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="5"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAQ90917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="335" mass="35212" checksum="D263CCECF0EE68FB" modified="2006-03-21" version="1">MATHNIVVFGGDHCGPEVVAEAVKVLRAIETHSPSVGKFNLQEHLLGGASIKVHNDPLTAKALAAAKAADAILLGAIGGPEWGPSSPVRPEEGLLRLRKELGTYGNLRPCNFASDSLVDSSPLKADVCRGTDFIVVRELTGGIYFGARTEDDGSGFAMDTDAYSRAEIERIARLAGFLALGTSPPSKVWSLDKANVLATSRLWRKVVTEVFANEFPQLEVGHQLIDSAAMLMVKSPRALNGVVVTSNLFGDIISDEASVIPGSIGAGIVNPIGTILSVAMMLRYSLNLPKEAAAVEAAVRTALDNGTRTKDLGGSAGTFQMADAVVVELVKLLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HB93</accession>
    <name>Q2HB93_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_02511</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229027.1">
        <property type="nucleotide sequence ID" value="XM_001229026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HB93"/>
    <dbReference type="FunCoup" id="Q2HB93">
        <property type="interactions" value="764"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HB93"/>
    <dbReference type="GeneID" id="4389700"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02511"/>
    <dbReference type="eggNOG" id="KOG2719">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025947_3_3_1"/>
    <dbReference type="InParanoid" id="Q2HB93"/>
    <dbReference type="OMA" id="HWHYSHI"/>
    <dbReference type="OrthoDB" id="360839at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="9">
        <location>
            <begin position="40"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="8">
        <location>
            <begin position="201"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ90576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="341" mass="38889" checksum="36A08A0DE4C37436" modified="2006-03-21" version="1">MDFLQRLARFLDRPLFPWKKLIIGFSVGQYVFEALLGYRQYKILQKTKPPKVLEHEVSQEVFDKSQAYGRAKAKFTGFNGLYGQLQNLAFYHFDVLPKLWSWTGDLLLRFAPKGFTGEISHSIVFILSFILINQVLSLPSNIYNTFVLEEKFGFNKQTPKLFVVDMIKTNLLAFVLTPPILSGFLAIIQKTGSQRTSFTSSLSCSVFVNNNSLYSDFGFTNQHPIIVGFLLFSDILGPLDNVIKLLMNILSRKFEFEADGFCQRPRVQHRASSLAMIKLQIQNLSTMDADWMFASYHFSHPILSERLKALNWQPTEKVEVKGGDKEAAKEDVATATGRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCU6</accession>
    <name>Q2HCU6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221179.1">
        <property type="nucleotide sequence ID" value="XM_001221178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCU6"/>
    <dbReference type="FunCoup" id="Q2HCU6">
        <property type="interactions" value="1219"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HCU6"/>
    <dbReference type="GeneID" id="4387749"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01958"/>
    <dbReference type="eggNOG" id="KOG1889">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003016_7_4_1"/>
    <dbReference type="InParanoid" id="Q2HCU6"/>
    <dbReference type="OMA" id="ITKAQPV"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072517">
        <property type="term" value="C:host cell viral assembly compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052629">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061909">
        <property type="term" value="P:autophagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="592"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="625"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="118"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="706" mass="80021" checksum="2E2338798AE5B48E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCY0</accession>
    <name>Q2HCY0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_01924</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221145.1">
        <property type="nucleotide sequence ID" value="XM_001221144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCY0"/>
    <dbReference type="STRING" id="306901.Q2HCY0"/>
    <dbReference type="GeneID" id="4386443"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01924"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_320282_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCY0"/>
    <dbReference type="OMA" id="RWANDTT"/>
    <dbReference type="OrthoDB" id="4576410at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01345">
        <property type="entry name" value="CERVTRCPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="201"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="735"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="857"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="743"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ93689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="906" mass="99875" checksum="E0E7F47FC1168502" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HD78</accession>
    <name>Q2HD78_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221047.1">
        <property type="nucleotide sequence ID" value="XM_001221046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HD78"/>
    <dbReference type="STRING" id="306901.Q2HD78"/>
    <dbReference type="GeneID" id="4386958"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01826"/>
    <dbReference type="eggNOG" id="KOG1605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020262_2_1_1"/>
    <dbReference type="InParanoid" id="Q2HD78"/>
    <dbReference type="OMA" id="HVCLLDN"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000093">
        <property type="entry name" value="NLI interacting factor-like phosphatase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="104"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="314" mass="34021" checksum="F49319517BD08600" modified="2006-03-21" version="1">MEGRLKKGGLLALFGCCGVPDSANGIDTEAPVPSHKLDKIPARPATASRRTATPSEQPSGSRTHLSEKDVSQQAPLSIGSTRNGKRLSGVSTQDQSTVGGERDNESKQTTIVGPGASNLVISVEPPHTAGPDTDKVEEVPGERDAEGDVQMPDAEGSRQLGDQGSADFTIPVEIEGNYHNVYVIKRPGVDQFMKRVGELYEVVVFTASVSKYGDPLLDQLDIHKVVHHRLFRESCYNHQGNYVKDLSQVGRDLKDTIIIDNSPTSYIFHPQHAVPISSWFSDAHDNELLDLIPVLEDLAGPTVRDVSLVLDVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HD92</accession>
    <name>Q2HD92_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">ATP synthase F(0) complex subunit e, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CHGG_01812</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 15">Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the ATP synthase complex composed at least of ATP5F1A/subunit alpha, ATP5F1B/subunit beta, ATP5MC1/subunit c (homooctomer), MT-ATP6/subunit a, MT-ATP8/subunit 8, ATP5ME/subunit e, ATP5MF/subunit f, ATP5MG/subunit g, ATP5MK/subunit k, ATP5MJ/subunit j, ATP5F1C/subunit gamma, ATP5F1D/subunit delta, ATP5F1E/subunit epsilon, ATP5PF/subunit F6, ATP5PB/subunit b, ATP5PD/subunit d, ATP5PO/subunit OSCP. ATP synthase complex consists of a soluble F(1) head domain (subunits alpha(3) and beta(3)) - the catalytic core - and a membrane F(0) domain - the membrane proton channel (subunits c, a, 8, e, f, g, k and j). These two domains are linked by a central stalk (subunits gamma, delta, and epsilon) rotating inside the F1 region and a stationary peripheral stalk (subunits F6, b, d, and OSCP).</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ATPase e subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221033.1">
        <property type="nucleotide sequence ID" value="XM_001221032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HD92"/>
    <dbReference type="FunCoup" id="Q2HD92">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HD92"/>
    <dbReference type="GeneID" id="4388295"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01812"/>
    <dbReference type="eggNOG" id="ENOG502SDS3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159435_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HD92"/>
    <dbReference type="OMA" id="FYGLYHQ"/>
    <dbReference type="OrthoDB" id="2125027at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008386">
        <property type="entry name" value="ATP_synth_F0_esu_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12427">
        <property type="entry name" value="ATP SYNTHASE E CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12427:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT E, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05680">
        <property type="entry name" value="ATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11 15" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 15" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 15" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAQ93577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="96" mass="10395" checksum="262ED24DDA08F3AE" modified="2006-03-21" version="1">MSSKSGINVLRYSVLGLGVFYGFSHQRSINSAQKAAEAQREYEHKQQLINKAKDAYAKSKQQTSGASAPASSAASQDLTSPNFDLEALIEGIMNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDG2</accession>
    <name>Q2HDG2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">nitric oxide dioxygenase</fullName>
            <ecNumber evidence="2">1.14.12.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_01742</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 nitric oxide + NADH + 2 O2 = 2 nitrate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 nitric oxide + NADPH + 2 O2 = 2 nitrate + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="2"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220963.1">
        <property type="nucleotide sequence ID" value="XM_001220962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDG2"/>
    <dbReference type="FunCoup" id="Q2HDG2">
        <property type="interactions" value="305"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HDG2"/>
    <dbReference type="GeneID" id="4386774"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01742"/>
    <dbReference type="eggNOG" id="KOG3378">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_12_0_1"/>
    <dbReference type="InParanoid" id="Q2HDG2"/>
    <dbReference type="OMA" id="KLERMCN"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase NAD(P)H activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071500">
        <property type="term" value="P:cellular response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046210">
        <property type="term" value="P:nitric oxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08922">
        <property type="entry name" value="FHb-globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06184">
        <property type="entry name" value="flavohem_like_fad_nad_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.10:FF:000003">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0216">Detoxification</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin" evidence="10">
        <location>
            <begin position="2"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="149"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ93507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="423" mass="47095" checksum="F8027F69B424FB14" modified="2006-03-21" version="1">MALTYQQSKLVKDTIPALREKGEQITTSFYKTMLQNHPELNDYFNSVNQKNGRQPRALTSVILNFASNINHTSELIPKLERMCNKHCSLGIQPEHYGIVGKYLLGAFGEVLGPAMTPAVLAAWERAYWLLAKMLMGREAQLYRAFAAWPSWRAFQVDRVVREAGADGDDIYSFYLVPRDGAPLPRFLPGQYVSLRIRAPESHLQARQYSLSDAWREDYYRISVKRDEGARYANSVSRSYFHPGLVSNALIDHTGPGSVVELSHPAGDFFFDVANNTSAMPVVLISAGVGATPMVAIANTIAATQPGRAVSWIHGSRRSVPFEAHVARLRRECQPAFRAAIFKSRPAPGDVPGPNAGFDFVGRVDLARLDQDRDLHLRSSGAEYYICGPEPFMVDMADYLRTRGVGPERLKLELFSTGELALKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HE87</accession>
    <name>Q2HE87_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220688.1">
        <property type="nucleotide sequence ID" value="XM_001220687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HE87"/>
    <dbReference type="GeneID" id="4386555"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01467"/>
    <dbReference type="HOGENOM" id="CLU_2978935_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HE87"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="58" mass="6738" checksum="57B54336FEAECCE9" modified="2006-03-21" version="1">MSLNANSMRKDHGLTPTWKREPSHVRGQKVVTLTRDSYMRLECLLTLHYSYHAADLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HE88</accession>
    <name>Q2HE88_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADP-ribosylation factor GTPase-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_01466</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase-activating protein for the ADP ribosylation factor family.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220687.1">
        <property type="nucleotide sequence ID" value="XM_001220686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HE88"/>
    <dbReference type="STRING" id="306901.Q2HE88"/>
    <dbReference type="GeneID" id="4386554"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01466"/>
    <dbReference type="eggNOG" id="KOG0521">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002728_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HE88"/>
    <dbReference type="OMA" id="ITPNAFP"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07608">
        <property type="entry name" value="BAR_ArfGAP_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000051">
        <property type="entry name" value="ARF GTPase activator (Csx2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000252">
        <property type="entry name" value="ARF GTPase activator (Csx2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000017">
        <property type="entry name" value="ARF GTPase activator (Csx2), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF160">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN EFFECTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="643"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="8">
        <location>
            <begin position="819"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="537"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="797"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1059"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="576"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="601"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1079"/>
            <end position="1088"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ93231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1106" mass="122159" checksum="759466F39767E26D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEG8</accession>
    <name>Q2HEG8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chromate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_01386</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220607.1">
        <property type="nucleotide sequence ID" value="XM_001220606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEG8"/>
    <dbReference type="STRING" id="306901.Q2HEG8"/>
    <dbReference type="GeneID" id="4387699"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01386"/>
    <dbReference type="eggNOG" id="ENOG502QRJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_836784_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HEG8"/>
    <dbReference type="OrthoDB" id="2160638at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567:SF3">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ93151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="36736" checksum="8CCF60BEF27EA4B1" modified="2006-03-21" version="1">MGVKTGWSPTNWAWDNLWERDLSRKLWNTVRETWYLGFTSFGGPPVHFKIFHDKFVTKLHWIDEEVAFSGPGSTKMLYCINLIHDGFLSAVLGFLIWSLPAALGMFGLAIGISNVNETLPGPVYALLSGLNAATVGIIALAAVQLAQKAITDKLTRLLVFLGAAAGLLYNALWYFPLLMLIAGIIAVIHDFRWLHGPVNSFHTHPAFATPSTPSWTLKFATARNRHHLRWASAMEVSRTKLTVPKRALAGRRSDSAMELVRGLPIRLMVVTSRRVLGGAVRANRSRMARDHRAYGGRCRWMAATKEDVLQATLGWGEAVLPAVLRRGSPAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEH0</accession>
    <name>Q2HEH0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">fumarate reductase (NADH)</fullName>
            <ecNumber evidence="7">1.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NADH-dependent fumarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_01384</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="7"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220605.1">
        <property type="nucleotide sequence ID" value="XM_001220604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEH0"/>
    <dbReference type="FunCoup" id="Q2HEH0">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HEH0"/>
    <dbReference type="GeneID" id="4387697"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01384"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011398_4_5_1"/>
    <dbReference type="InParanoid" id="Q2HEH0"/>
    <dbReference type="OMA" id="EDLWVVV"/>
    <dbReference type="OrthoDB" id="10252157at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF1">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="531"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ93149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="615" mass="66512" checksum="013157459D401BCB" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEH9</accession>
    <name>Q2HEH9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription initiation factor TFIID subunit 1 histone acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_01375</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220596.1">
        <property type="nucleotide sequence ID" value="XM_001220595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEH9"/>
    <dbReference type="FunCoup" id="Q2HEH9">
        <property type="interactions" value="357"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HEH9"/>
    <dbReference type="GeneID" id="4387393"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01375"/>
    <dbReference type="eggNOG" id="KOG0008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000572_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HEH9"/>
    <dbReference type="OMA" id="RFINYYR"/>
    <dbReference type="OrthoDB" id="5752at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 1 histone acetyltransferase" evidence="4">
        <location>
            <begin position="404"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="16"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="983"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1063"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="987"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1015"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1084"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1117"/>
            <end position="1126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ93140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1126" mass="127009" checksum="5F6903E7D2E5B78C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEI5</accession>
    <name>Q2HEI5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_01369</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220590.1">
        <property type="nucleotide sequence ID" value="XM_001220589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEI5"/>
    <dbReference type="STRING" id="306901.Q2HEI5"/>
    <dbReference type="GeneID" id="4387387"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01369"/>
    <dbReference type="eggNOG" id="KOG4628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031409_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HEI5"/>
    <dbReference type="OMA" id="TKYKQWK"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16473">
        <property type="entry name" value="RING-H2_RNF103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000539">
        <property type="entry name" value="Ring finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF434">
        <property type="entry name" value="GB|AAD18119.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="316"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ93134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="507" mass="53486" checksum="2F28EC81069A3F07" modified="2006-03-21" version="1">MAFLNPAVVEAVRVVVRQATEVAVTTALSQTPIIATPSPATAPPVTSATLTSLGPSPTDSSTLANGGPSTGGDSGGDSGGGGGGGGGGGGNSSSLLFFVALGFGVVFTNLWIIVGVKYCFRYNARARQMRNEEGEPIGMEAVPRPHRRRREKKLMPIDEVNEKFPMVKYKSWVASRAQEGLPTRGGVSVPQSRPNSVRDAEGTIREASLRERPSTDGRPTTSATATGIAMEPTSETTAENTEKPPVQSPRHVPKESTSSTVAGLRRASTDSNRDPDPDTAVADKHLSQISHDEDDEDEHIDAALPPECLGTSGDTCAICIDALEDDDDVRGLTCGHAFHAACIDPWLTTRRACCPLCKADYFTPKLRPQATTDGADGQTPVVHVTVTANARNNRMNLPGRPRPAFFSFGRTDQNRRPTANRSRPRETGGSAIPGRQRSRPSPASPPRDATPAQSGASGLLSNLRNAIPTFRFGRGQSGQTDQTQPDPAPSSAVTPSQLEAGVRAAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEJ2</accession>
    <name>Q2HEJ2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220583.1">
        <property type="nucleotide sequence ID" value="XM_001220582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEJ2"/>
    <dbReference type="GeneID" id="4387017"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01362"/>
    <dbReference type="eggNOG" id="ENOG502RUPA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1008324_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HEJ2"/>
    <dbReference type="OrthoDB" id="4589716at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="30671" checksum="A65BF3DD96DEB267" modified="2006-03-21" version="1">MASAGTEGDDAYPLSRPWLLNKAKRANNTGMWRTGRRPAEPPEGEVSDFSDRGALVPAIIAVCSFMMATALVTTGGRLVLIYSLVFWLLMVRGGQNFILRAISGISRCAGSLVIRSRAVIATTVSLVYRIRLWANSPDKSWKAAIVLLCSVVELHITIIVSSMPGFSKFVRVYFVSKRKKIRHTSSEDSSQWNTPRARRDREQYLELDESWLFRSDQRGEEPADNTPGPRPTATSGTVKRLNPDSQALSKTLPDNVMIVRGISGEDVFRVQGVERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HES4</accession>
    <name>Q2HES4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_01280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220501.1">
        <property type="nucleotide sequence ID" value="XM_001220500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HES4"/>
    <dbReference type="STRING" id="306901.Q2HES4"/>
    <dbReference type="GeneID" id="4387403"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01280"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HES4"/>
    <dbReference type="OMA" id="QYDNAGQ"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07093">
        <property type="entry name" value="ALDH_F8_HMSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720:SF2">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="60"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ93045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="522" mass="57213" checksum="F9283134A58C6EF6" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HF42</accession>
    <name>Q2HF42_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="2 11">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_01162</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 11">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="2 11"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220383.1">
        <property type="nucleotide sequence ID" value="XM_001220382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HF42"/>
    <dbReference type="FunCoup" id="Q2HF42">
        <property type="interactions" value="501"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HF42"/>
    <dbReference type="GeneID" id="4387350"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01162"/>
    <dbReference type="eggNOG" id="KOG2711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033449_2_3_1"/>
    <dbReference type="InParanoid" id="Q2HF42"/>
    <dbReference type="OMA" id="NRMFGNM"/>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000294">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017751">
        <property type="entry name" value="G3P_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03376">
        <property type="entry name" value="glycerol3P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0520">NAD</keyword>
    <keyword evidence="3 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="12">
        <location>
            <begin position="13"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="13">
        <location>
            <begin position="254"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="330"/>
            <end position="331"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ92927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="405" mass="44959" checksum="6E65C304AC13F2C7" modified="2006-03-21" version="1">MAGPSDSIRRKHKVTVVGSCNWGTTVAKLVAENTKEHSDIFEEDVQMWVYEENVTIPSDSPHHAAVGDKPQKLTKVINTYHENVKYLPKIPLPSNVVANPSLVDAVKDSSILIFNLPHEFIGNVCKQIKGQILPYARGVSCIKGVTVTEDKVELICEYISESLGIYCGALSGANIANEIANELWCETTIAYNTPPCDRQGENGSNGTNGEHRDARGQISKTELTPLPQEYHPLDHAELQKLFDRPYFTVSMVSDVVGVSLAGALKNIVALACGFIEGHGWNMTAKTAVMRRGMLETIQFCQEFFPETIQEMTFFESAGWSDMIVSCTSARNWRYSKLAVERGVSLYEVERTELNGQKLQGISTTKEVMSFLKARGVQDKYPLFKAVEGIVDGTFEVKDIPVLFRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HF80</accession>
    <name>Q2HF80_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">YjeF C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_01124</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220345.1">
        <property type="nucleotide sequence ID" value="XM_001220344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HF80"/>
    <dbReference type="SMR" id="Q2HF80"/>
    <dbReference type="STRING" id="306901.Q2HF80"/>
    <dbReference type="GeneID" id="4387634"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01124"/>
    <dbReference type="eggNOG" id="KOG3974">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2385943_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HF80"/>
    <dbReference type="OrthoDB" id="8110916at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF C-terminal" evidence="7">
        <location>
            <begin position="8"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ92889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="94" mass="10238" checksum="6ACAB226FE4ABD49" modified="2006-03-21" version="1">MSPATKDIIARVRQMIPPMLEKFHKGQLGRVGVIGGSEDYTGAPYFSAMASARLGCDMVGRYSCTPISSPLVVLRHTESMPRRKRCDAVPGATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFP8</accession>
    <name>Q2HFP8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4110 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220177.1">
        <property type="nucleotide sequence ID" value="XM_001220176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFP8"/>
    <dbReference type="FunCoup" id="Q2HFP8">
        <property type="interactions" value="583"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HFP8"/>
    <dbReference type="GeneID" id="4387206"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00956"/>
    <dbReference type="eggNOG" id="KOG1230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008722_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HFP8"/>
    <dbReference type="OMA" id="PSPRVGC"/>
    <dbReference type="OrthoDB" id="4447at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025183">
        <property type="entry name" value="DUF4110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052588">
        <property type="entry name" value="Kelch_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13422">
        <property type="entry name" value="DUF4110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4110" evidence="2">
        <location>
            <begin position="610"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="587"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ92721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="713" mass="79820" checksum="40A130EBCFBDF21B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG22</accession>
    <name>Q2HG22_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220053.1">
        <property type="nucleotide sequence ID" value="XM_001220052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG22"/>
    <dbReference type="STRING" id="306901.Q2HG22"/>
    <dbReference type="GeneID" id="4387755"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00832"/>
    <dbReference type="eggNOG" id="ENOG502RXF7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049614_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HG22"/>
    <dbReference type="OMA" id="NAFGHSQ"/>
    <dbReference type="OrthoDB" id="2430277at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00246">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
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        </location>
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        <location>
            <begin position="1"/>
            <end position="441"/>
        </location>
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            <begin position="1"/>
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        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="160"/>
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        </location>
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        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="268"/>
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            <begin position="269"/>
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        <location>
            <begin position="403"/>
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            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ92597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="441" mass="42894" checksum="5B6896804B3A36A9" modified="2006-03-21" version="1">MPPPPPPPPPPPPGFGGPPPPPPPPPPAAAAAAPGRGALLADIHKGKALKKTVTNDRSAPVVAKSSSGGGPGPSGLGAPPIPGLPKAPGGLAPPVPGARARSNSDQSDGAQPAGSSMDGPPQLAGLFTGGMPKLRKTGGGVDTGANRDASYLSDSEAPPRAAPRPPVAAAPPVPGRPALPNTNSAPSFPKKGRPPPVGKKPPPPPPGSRKPSSTVPSAAPPPPPSFAPPTPSPSAFSPPPAPPPPPPAAAPRPPPAPARSQPPPPPPSASTSNISQSIAAQAAIRAASSVGPPPGAAPPPPPPPPPNGPSRSAPPISPPPAPAPPPPPSSAPAPPPPSLSHSASSASGRASMLSMLDPSNFTLAPNGSGSKTPSPGRGPSPSPGLSTSSGGGGGGERYVVQDSRWRFHGEENFPKPRNFTGGARKYRAGRGSSVPLDLSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
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        <property type="match status" value="8"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="346" mass="36643" checksum="CDA6EBABEAA8E58B" modified="2006-03-21" version="1">MVQTTASVGEGTDNGNVQETISHAVHENAGPPAPDEHSDNLHSAGSDLGQLASASADGTVKLWDPATHQCSATLEGHGGSVFSVVWSPDGTQLASGSADRTIKIWNPATGQCTATLESHAGSVLSVAWSPDGTQLASGSRDGPIEIWDLATAQCVATLKGHDSAVLSVSWSSNGWELVSGSEDQTIRTWDMTNTWCTMILEAFRELVLSVAWSPDGYKIASGPDDTIIKIWGEDYRSSLTLEGHTRSVGSVAWSPDGARLASGSDDRTVKVWDLWDLDHGECTTTLLGHDKFVQSVAWSPNGARLASGSDDETVKIWDPVTSECVATLEGHEDTVYSVAWSPGPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGJ7</accession>
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            <taxon>Sordariomycetes</taxon>
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGJ7"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00657"/>
    <dbReference type="eggNOG" id="ENOG502RN00">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_472509_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGJ7"/>
    <dbReference type="OMA" id="YLWIDED"/>
    <dbReference type="OrthoDB" id="5238042at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
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            <end position="116"/>
        </location>
    </feature>
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            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="96"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="227"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="484"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="577" mass="64139" checksum="617313ECFBEFD80A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGW0</accession>
    <name>Q2HGW0_CHAGB</name>
    <protein>
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            <fullName evidence="3">DNA polymerase epsilon subunit B</fullName>
        </recommendedName>
        <alternativeName>
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        </alternativeName>
    </protein>
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        <name evidence="10" type="ORF">CHGG_00544</name>
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    <organism evidence="10 11">
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase epsilon subunit B family.</text>
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        <property type="protein sequence ID" value="EAQ92309.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001219764.1"/>
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    <dbReference type="FunCoup" id="Q2HGW0">
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    </dbReference>
    <dbReference type="STRING" id="306901.Q2HGW0"/>
    <dbReference type="GeneID" id="4387897"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00544"/>
    <dbReference type="eggNOG" id="KOG3818">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010628_1_0_1"/>
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    <dbReference type="OrthoDB" id="10254730at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="9">
        <location>
            <begin position="484"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="659"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ92309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="827" mass="88590" checksum="F3F0B60D6404BFBA" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHP7</accession>
    <name>Q2HHP7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_00257</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219478.1">
        <property type="nucleotide sequence ID" value="XM_001219477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHP7"/>
    <dbReference type="STRING" id="306901.Q2HHP7"/>
    <dbReference type="GeneID" id="4388160"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00257"/>
    <dbReference type="eggNOG" id="ENOG502SQDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055859_4_0_1"/>
    <dbReference type="InParanoid" id="Q2HHP7"/>
    <dbReference type="OMA" id="WASPECA"/>
    <dbReference type="OrthoDB" id="5215637at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208970" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ92022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="29052" checksum="DCC59EE5C6836C78" modified="2006-03-21" version="1">MRLSWGLTVSCILFFTCICVAQDQCYAPNGQTDDNFFPCDPNATHSTCCNGRSTCLSNKLCMGPDGNLIRGLCTDKNWQSPECAYYCMSAIRGGHDLISCSNVTNTDTSFCCDGHRAFCCDDGVARFNVLPSNPQAWATWDNSASHFVVVQDLKTTSTGSLPAATGTSTTPSTTPPAATTDSDQTQSAPTSPTATDTSTPSESPQSTTLPIAAQAGIGVGIGALAIALAAVAYLLWKLRRSKKALLAEKEQSNNGAGALGYLHAATIRHSWSSSAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHU0</accession>
    <name>Q2HHU0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219435.1">
        <property type="nucleotide sequence ID" value="XM_001219434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHU0"/>
    <dbReference type="STRING" id="306901.Q2HHU0"/>
    <dbReference type="GeneID" id="4387759"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00214"/>
    <dbReference type="eggNOG" id="ENOG502SICY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002639_3_1_1"/>
    <dbReference type="InParanoid" id="Q2HHU0"/>
    <dbReference type="OMA" id="HEYARIL"/>
    <dbReference type="OrthoDB" id="5362512at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="204"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="607" mass="67401" checksum="C770B855FD66FEBE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI18</accession>
    <name>Q2HI18_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219357.1">
        <property type="nucleotide sequence ID" value="XM_001219356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HI18"/>
    <dbReference type="STRING" id="306901.Q2HI18"/>
    <dbReference type="GeneID" id="4387919"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00136"/>
    <dbReference type="eggNOG" id="ENOG502SJ7Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024672_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HI18"/>
    <dbReference type="OMA" id="LWREDDI"/>
    <dbReference type="OrthoDB" id="4581035at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="682" mass="76605" checksum="CE994EC945574FF0" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI90</accession>
    <name>Q2HI90_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_00064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219285.1">
        <property type="nucleotide sequence ID" value="XM_001219284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HI90"/>
    <dbReference type="GeneID" id="4386579"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00064"/>
    <dbReference type="eggNOG" id="ENOG502SSRW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_679718_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HI90"/>
    <dbReference type="OrthoDB" id="5350472at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ91829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="405" mass="44773" checksum="53F10F56D6BB182E" modified="2006-03-21" version="1">MGTCRWSGKAPLHWTSRSNWAGDSEPGIKTGAMGTPDILNFGGKRLDELYNTTGSRDAVFAYLQSVIDNYATLNPRISDATKEQLEIIKDQIELLSLPSGAEYMGADMDPDPQHIRRELDPVWPATKGKPSDKERKGYSMFKVLANAGHSWAVYTGDDKRRYWNQYDLLGLFLSKMGPAPGGSVADQSNFYLPLTAVYAKFCLWIGGKQIPTMKGAEKQSKKGTGTGDPPACFQCTWNSDTGDFFLGASLAGIRVTGSTKPYGAWENKVMEARWNLLNNNFFEFPGDWGPFQEKKSPVISYQGKTTLFGNCGETYPFLEIISPHVTDDKVRAQTRGLALGKSFAGVAEYNEDSFAPMLIPPCLNCQLLLLFAGISDVTHFTLNSRMKTPLFPTPVAGYWEPDSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-10-17" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q0C722</accession>
    <name>Q0C722_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_11117</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH670334">
        <property type="protein sequence ID" value="EAQ82858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230269.1">
        <property type="nucleotide sequence ID" value="XM_001230268.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4397409"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_11117"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002055_0_0_1"/>
    <dbReference type="InParanoid" id="Q0C722"/>
    <dbReference type="OMA" id="WELENTW"/>
    <dbReference type="OrthoDB" id="5242358at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="812"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="466"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1083"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1137"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1094"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ82858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1712" mass="193392" checksum="DF1742E3B71212CB" modified="2006-10-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM08</accession>
    <name>Q2GM08_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_11048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408038">
        <property type="protein sequence ID" value="EAQ82872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230218.1">
        <property type="nucleotide sequence ID" value="XM_001230217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GM08"/>
    <dbReference type="STRING" id="306901.Q2GM08"/>
    <dbReference type="GeneID" id="4397393"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_11048"/>
    <dbReference type="eggNOG" id="ENOG502S130">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_311450_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GM08"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38886:SF1">
        <property type="entry name" value="NACHT-NTPASE AND P-LOOP NTPASES N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38886">
        <property type="entry name" value="SESA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ82872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="943" mass="105666" checksum="531CDD97F04805C1" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMI3</accession>
    <name>Q2GMI3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidate phosphatase APP1 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226088.1">
        <property type="nucleotide sequence ID" value="XM_001226087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMI3"/>
    <dbReference type="STRING" id="306901.Q2GMI3"/>
    <dbReference type="GeneID" id="4397180"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10821"/>
    <dbReference type="eggNOG" id="ENOG502RYXR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030283_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GMI3"/>
    <dbReference type="OMA" id="RDSSWKT"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF1">
        <property type="entry name" value="FILAMENT ORGANIZATION PROTEIN APP1-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="2">
        <location>
            <begin position="202"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="382" mass="42005" checksum="157664D8CF9851BB" modified="2006-03-21" version="1">MSFRRTTSSLMEERTRSHGNFSDTESSLASISTNQVRASRKEHKLTHLLSYLGSNNPLPASIEADDVIWLMDNVAFRGRGGEWEAEFVAAGFDEKASPKVVDIVGDIASKVGLSRGGAEEKTIERRISPFVMEVLPGRQIKVNYDGATSVKLGPGGRNGISSNVIRIPKAAAGGVARTTADVPMGVTGVLEMKTVYAEPEGWAVISDVDDTIKITQTSDPVGILKSTFVSEPTPVPGMPALYARIQELLTPSAPFFYLSASPYNLYPFLRTFRDAHFPHGQLILRDSSWMTISGLLSSLTLGTEKYKIDRIKKIHRWLPRRNMIFIGDSTQSDPEAYGDACRAFPGWAKLVLIRKVTDIAAVGIEEKNEPQRFEKAFEGVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMN4</accession>
    <name>Q2GMN4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_10770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ82952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226037.1">
        <property type="nucleotide sequence ID" value="XM_001226036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMN4"/>
    <dbReference type="STRING" id="306901.Q2GMN4"/>
    <dbReference type="GeneID" id="4397352"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10770"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008638_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GMN4"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="442"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="530"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ82952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="804" mass="89975" checksum="1FBD87E6FD8803D7" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMT4</accession>
    <name>Q2GMT4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trichothecene 3-O-acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228647.1">
        <property type="nucleotide sequence ID" value="XM_001228646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMT4"/>
    <dbReference type="STRING" id="306901.Q2GMT4"/>
    <dbReference type="GeneID" id="4396217"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10720"/>
    <dbReference type="eggNOG" id="ENOG502SHDQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026450_2_1_1"/>
    <dbReference type="InParanoid" id="Q2GMT4"/>
    <dbReference type="OMA" id="QHNVMFA"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF13">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="49973" checksum="C9578EC43F821B56" modified="2006-03-21" version="1">MFPTCNCSTSSLPARATSLERTLSQARHYVGTIEKDPEGGHSFVRKKNSTVRFVVQWLDAPEESTKYPSIDDIERANYSAVTLGNLETWSVPPMTYGEKPEAHPDNHPVVSAFQANFVRGGLVLNMHHHHYANDVMGWSGFTHQLAENCRAALTNTAFPTWDLACLDLSRLTKKEMADEVKVDGPPQAERHPGHKVAQLLLFHLPKSKAAQLKTLASPTDGSWISTYDAFSAFIWRTLTRLRTPVFKPNPSSHIFWAEAVDMRRRMHSPKVHPRIQHNVMFAALSSTAPVQQLTIDEILHAPLSTLALYIRRMTSSVTQENLDKTLDMVAMVRDKTSLNIRIDSHPPMSILQTDHRDANIVSADFGFATPLTYRHLLDRVTEGVIIIYPTRDNNPGSDEGPEFSMAYEKHLADDLINDTEFRMYFEYRGVDAEDARMPSRCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNS2</accession>
    <name>Q2GNS2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_10382</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228309.1">
        <property type="nucleotide sequence ID" value="XM_001228308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNS2"/>
    <dbReference type="STRING" id="306901.Q2GNS2"/>
    <dbReference type="GeneID" id="4396620"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10382"/>
    <dbReference type="eggNOG" id="KOG4208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025741_5_2_1"/>
    <dbReference type="InParanoid" id="Q2GNS2"/>
    <dbReference type="OMA" id="WKGANKR"/>
    <dbReference type="OrthoDB" id="21467at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12307">
        <property type="entry name" value="RRM_NIFK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="167"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="353"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ83978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="381" mass="41746" checksum="8771BC233E961DEE" modified="2006-03-21" version="1">MAPELRKRKSKPVVAEPEPVAKKSKATKSPKAEKRKAPEDASPVAVKKQKPTKDVASKKVATPAEKAAPKKSALKKERQSPKAKAAAEKSKKGEESEEVQDGDVLSEAEEEEVDDDTKALVQALDSGDEDEAGAQVSTFKKGQDVGKVPKAKKSTKAPTSSSSGTPGVMYLARIPHGFYEHELRSYFGQFGDITRLRVVRNKKTGASRHRAFVEFADAEVADIAARTMDKYLLFGHILSAKTVPPAQVHPDLFKGANRRFKVVPWNKMAGKQLERPLSESQWQVKISKEEQRRAARADKLKEMGYEFEAPALKAAEAKPLLENGTEEEPKAIEAPPATETAEPKEEEEVVEAEVVKAKTTKSSEDATPQKKKGKKAKKTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GP30</accession>
    <name>Q2GP30_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial phosphate carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_10274</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228201.1">
        <property type="nucleotide sequence ID" value="XM_001228200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GP30"/>
    <dbReference type="FunCoup" id="Q2GP30">
        <property type="interactions" value="597"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GP30"/>
    <dbReference type="GeneID" id="4396824"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10274"/>
    <dbReference type="eggNOG" id="KOG0767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039456_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GP30"/>
    <dbReference type="OMA" id="TCCAITH"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000024">
        <property type="entry name" value="MIR1p Mitochondrial phosphate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF12">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="16"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="115"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="213"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ83870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="32188" checksum="D5BC8A92EBF26DAC" modified="2006-03-21" version="1">MAAKVDAPAPQLSGVQLYSRFALAGAICCSVTHGGMTPVDVVKTRIQLDPVTYNNGMIGGFKKVVQAEGAGALLTGVGPTFAGYFLPGRLSSSAVTSSSSSSSINYLGYETASNYRTGVYLASSALAEFFADIALCPLEATRIRLVSEPTYASGLVSGFGKMLKQEGVGAFYAGFGPILFKQIPYTMTKFVVYEKVAEAVFRVFPKKDLSDGMQTVVNLGSGLMAGFAAAIVSQPADTMLSKINKTKGAPGEGTTTRLIKIAKELGLRGSYAGIGARLFMVGTLTAGQFAIYGDVKKILGATGGVEISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPF5</accession>
    <name>Q2GPF5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_10149</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228076.1">
        <property type="nucleotide sequence ID" value="XM_001228075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPF5"/>
    <dbReference type="STRING" id="306901.Q2GPF5"/>
    <dbReference type="MEROPS" id="S12.950"/>
    <dbReference type="GeneID" id="4396870"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10149"/>
    <dbReference type="eggNOG" id="ENOG502S4UR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_11_1_1"/>
    <dbReference type="InParanoid" id="Q2GPF5"/>
    <dbReference type="OMA" id="RKGSMMW"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF17">
        <property type="entry name" value="(LOVD), PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="20"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ83745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="412" mass="44939" checksum="609F028505A5A138" modified="2006-03-21" version="1">MAEKLDSILKSYVADGTATKDKLLGASFVVVGKDGPIYQGSAGRTRVDPSSPPFQTDSITWVTSMTKLVTTACLMHLVSRGLVTLDEDLRPRVPELAALPILKGFAPDGEGGEKDSGAPLLEPNTHPITLRQLLTHTAGLGTNPGDPDLMRWAAWAGVTDNVASCTIAGWATPLKFAPGAGWYYGTGPDWAGQTLERVTGVSLGEYLREWVLEPLGMDGTGFFRGRVVGEGKKDRFVPISERDGETGELSERAEMFPAEPQYEAGGAGLYTCAGDYAKVMQAVLKGLDGEGILKKEVVDEMFRPQLDETQRAWLRGILWEFGSGAELPEDTPVDYGIGGTINMEDVEGKRRKGSMMWSGMCNSRWWIDRETGIGAAMFVNVFPYKDPNVLKMYDELERAVYAELVPKWQASQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2026-01-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPT7</accession>
    <name>CCDB_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Possible spiroacetal forming enzyme ccdB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cochliodone A biosynthesis cluster protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ccdB</name>
        <name type="ORF">CHGG_10017</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2025" name="J. Am. Chem. Soc." volume="147" first="11555" last="11563">
            <title>Mechanism of Unexpected In-Trans Post-PKS Polyketide Reduction in Cochliodone Biosynthesis.</title>
            <authorList>
                <person name="Sarmales-Murga C."/>
                <person name="Sato M."/>
                <person name="Kosaka M."/>
                <person name="Akaoka F."/>
                <person name="Watanabe K."/>
            </authorList>
            <dbReference type="PubMed" id="40111931"/>
            <dbReference type="DOI" id="10.1021/jacs.5c03717"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="3 5">Possible spiroacetal-forming enzyme; part of the gene cluster that mediates the biosynthesis of cochliodone A, a dimerized azaphilone (PubMed:40111931). Within the pathway, ccdB might be responsible for the formation of the spiroacetal group after the C10 reduction and C7 acetoxylation steps (PubMed:40111931). The pathway begins with the NR-PKS ccdL, the short-chain dehydrogenase ccdN, and the FAD-dependent monooxygenase ccdF that work in sequence to generate the pyranoquinone intermediate of the pathway. CcdL produces a benzaldehyde intermediate from the condensation of 5 malonyl-CoA units and one methylation, ccdN reduces the C11 carbonyl to an alcohol and ccdF completes the azaphilone core formation. The acetyltransferases ccdC, the acetate lyase ccdG and the trans-enoyl reductase ccdH then work in sequence to fully reduce the C10 position. CcdC is responsible for the acetylation of the C10/C11 alcohol formed earlier by ccdN and kept unmodified during the azaphilone core formation by ccdF, ccdG then performs the elimination of the C10 acetate group to generate the C9-C10 olefin, and ccdH eliminates the olefin to effect a full reduction of the polyketide backbone at C10. The O-acyltransferase ccdM is then responsible for the O-acetylation at C7 of the azaphilone core. CcdB might be responsible for the formation of the spiroacetal group. The remaining enzymes ccdO, ccdJ and ccdE catalyze the final steps of the biosynthesis of dimeric cochliodones. The enoyl reductase ccdO performs the reduction of the C1-C8a olefin to generate the enol necessary for dimerization, the multicopper oxidase ccdJ is responsible for the dimerization reaction that results in the formation of cochliodones from azaphilone monomers, and lastly, the FAD-dependent oxidase ccdE catalyzes the elimination of the enol to stabilize the compound for the generation of cochliodone A.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Reduces the production of cochliodone A.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227944.1">
        <property type="nucleotide sequence ID" value="XM_001227943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPT7"/>
    <dbReference type="GeneID" id="4395928"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10017"/>
    <dbReference type="eggNOG" id="ENOG502SM3U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045147_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPT7"/>
    <dbReference type="OMA" id="MVNGGAI"/>
    <dbReference type="OrthoDB" id="5293813at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208032" description="Possible spiroacetal forming enzyme ccdB">
        <location>
            <begin position="25"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="40111931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="40111931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="40111931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ83613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="394" mass="43178" checksum="6769C629321FE604" modified="2006-03-21" version="1" precursor="true">MRLILPLRHCLFVVLIARDLEVLAEPFSFPLPNGFPFPNETALEELFTRAGGNFTNAPLAPRFDDDSLTSWKLQAFNEFMEVAFFTQLIANISDSVAGYELDPSVREYVLTSLEAIQAQEEMHAYNANDAVRYFTNGSHMYPYPDPHMYIGLLANIQQRTAMHLGSDAHSIVYVLAQALGQEGQQSGWFRSLRGIPPSAEPFLTTSTREFALGWMQHWIVPGSCPNMHEIPLGILPALQLTAVSIGDASHSGNVTLLAPGAVDPGSQRVAFVNGALVPTIVPFKIRQTSPCGGGDQDVRDLRAIKRNRGNRRNQHRQIVLVSQGTADAEPEDVGGCIASTEIVADMPYARNVMHGLILMTVVENSADGENETVFITAQDVADATIYGPALLEWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPW3</accession>
    <name>Q2GPW3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_09991</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227918.1">
        <property type="nucleotide sequence ID" value="XM_001227917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPW3"/>
    <dbReference type="STRING" id="306901.Q2GPW3"/>
    <dbReference type="GeneID" id="4396660"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09991"/>
    <dbReference type="eggNOG" id="ENOG502RVXB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_3_0_1"/>
    <dbReference type="InParanoid" id="Q2GPW3"/>
    <dbReference type="OMA" id="FRLTEGW"/>
    <dbReference type="OrthoDB" id="5417887at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF42">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="45"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ83587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="403" mass="44627" checksum="50CF2A48457875BF" modified="2006-03-21" version="1">MLGPRGLARHAGREHDGQPRGDNHGPYLNSVIWSLAALSTLFLGLRVYSKLLRRRQLWWDDYFLIASWTALIVSVSLQSVGVAHGLGSHYGELDEGSITAVAIYSISAGFGSILATCWSKTSFAISLLRISTGRTRAFVWFILVSVNLVMGSVGVIQWVQCWPVRKLWYHEVAGSCFPPEIVQNYNTFTAAYSGLMDIVLALLPWKIIWTITIKKRERLGAMVAMSTGVLAGVMAFLKIKTLYVIGNDDTTTVDLFIFGTAEPATAIMAASIPILRNLLRRESQVKPAEFIQLAGNGQQEVGQSPTPEEANNEERKQEAGQSWARIAQLEQAQLLKGTASLPRASLGLDVDMGRIISDIMCYYMRRKGCGINNYIVIESSKPQLKRTWNPTLLHCSLATNYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPX8</accession>
    <name>Q2GPX8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_09976</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227903.1">
        <property type="nucleotide sequence ID" value="XM_001227902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPX8"/>
    <dbReference type="FunCoup" id="Q2GPX8">
        <property type="interactions" value="669"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GPX8"/>
    <dbReference type="GeneID" id="4396230"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09976"/>
    <dbReference type="eggNOG" id="KOG1768">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129451_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GPX8"/>
    <dbReference type="OMA" id="KCYCVSC"/>
    <dbReference type="OrthoDB" id="10262653at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1740.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="entry name" value="Ribosomal protein S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000892">
        <property type="entry name" value="Ribosomal_eS26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047864">
        <property type="entry name" value="Ribosomal_eS26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_eS26_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00733">
        <property type="entry name" value="RIBOSOMAL_S26E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ83572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="119" mass="13572" checksum="B175EA275F60570E" modified="2006-03-21" version="1">MVKKRKNNGRNKKGRGHVKPIRCSNCSRCTPKDKAIKRFTIRNMVESAAIRDISDASVFAEYTVPKMYLKLQYCVSCAIHGKIVRVRSTEGRRNRAPPPRVRYNKDGKKVVPTQNPKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQ01</accession>
    <name>Q2GQ01_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-acetolactate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_09953</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S)-2-acetolactate + H(+) = (R)-acetoin + CO2</text>
            <dbReference type="Rhea" id="RHEA:21580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15686"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="4.1.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; (R,R)-butane-2,3-diol biosynthesis; (R,R)-butane-2,3-diol from pyruvate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-acetolactate decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.5" evidence="4"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227880.1">
        <property type="nucleotide sequence ID" value="XM_001227879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQ01"/>
    <dbReference type="STRING" id="306901.Q2GQ01"/>
    <dbReference type="GeneID" id="4396276"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09953"/>
    <dbReference type="eggNOG" id="ENOG502S81V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072561_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQ01"/>
    <dbReference type="OMA" id="YKPMLEA"/>
    <dbReference type="OrthoDB" id="509395at2759"/>
    <dbReference type="UniPathway" id="UPA00626">
        <property type="reaction ID" value="UER00678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047605">
        <property type="term" value="F:acetolactate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045151">
        <property type="term" value="P:acetoin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17299">
        <property type="entry name" value="acetolactate_decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.80">
        <property type="entry name" value="Hypothetical protein, similar to alpha- acetolactate decarboxylase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005128">
        <property type="entry name" value="Acetolactate_a_deCO2ase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01252">
        <property type="entry name" value="acetolac_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35524">
        <property type="entry name" value="ALPHA-ACETOLACTATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35524:SF1">
        <property type="entry name" value="ALPHA-ACETOLACTATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03306">
        <property type="entry name" value="AAL_decarboxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001332">
        <property type="entry name" value="Acetolac_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0005">Acetoin biosynthesis</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ83549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="237" mass="26018" checksum="00B08B05E9A650E0" modified="2006-03-21" version="1">MAYNEIFQYSIISALVDGVASHGTPIARILEHGDHGLGTFRNMVGEMIVLNGDVYQMKADGSVVHINPEETVTPFATVTRFKPTITKRAAVAGKASLERLLTGLFPKARNHFLVVRMDGVFKEVNVRTAGGQTTPREGMVSVCARQTTHTFKNAKGTIVGFRCPQYVMGVNVAGDHFHFIAEDRQQGGHILAFETDGDVDISAAQMSKFHLELPTEDDEFNEAELKLQAQDIKKVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQ54</accession>
    <name>Q2GQ54_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_09900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the secreted LysM effector family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227827.1">
        <property type="nucleotide sequence ID" value="XM_001227826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQ54"/>
    <dbReference type="STRING" id="306901.Q2GQ54"/>
    <dbReference type="GeneID" id="4396263"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09900"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010591_8_2_1"/>
    <dbReference type="InParanoid" id="Q2GQ54"/>
    <dbReference type="OMA" id="NCNAFHT"/>
    <dbReference type="OrthoDB" id="2281372at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF2">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208881" description="LysM domain-containing protein" evidence="6">
        <location>
            <begin position="27"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="7">
        <location>
            <begin position="45"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="7">
        <location>
            <begin position="285"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="7">
        <location>
            <begin position="360"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="115"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="496"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="520"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ83496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="594" mass="62650" checksum="08E3B6D4D57957D6" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQ62</accession>
    <name>Q2GQ62_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_09892</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227819.1">
        <property type="nucleotide sequence ID" value="XM_001227818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQ62"/>
    <dbReference type="STRING" id="306901.Q2GQ62"/>
    <dbReference type="GeneID" id="4396781"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09892"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063727_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GQ62"/>
    <dbReference type="OMA" id="KRNIWSW"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="159"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ83488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="245" mass="26058" checksum="20B29E3ADA188875" modified="2006-03-21" version="1">MNPNSLTNRNPRIDPSIRLRRAIHSNDALLARRILKSHPHLLHNPDLSLTGNASSNLHLAASLGHLPICKLLLELGHEADTPALNDDHQTALMLAAAAGHTEVVHLLSEHDPASILRQDARGRDAIMEASLHGHDTLVQILLTYAPGGAAAALAQADVDGNTALHFASSNGNLLVLRTLLAAGADAGRMNAWSWTAEAYSATVQAEVYLKTLVGEVERRKQARREGEAAAKTGGAVRLVGQEVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRK3</accession>
    <name>Q2GRK3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mannose-1-phosphate guanyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GDP-mannose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">GTP-mannose-1-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_09401</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227328.1">
        <property type="nucleotide sequence ID" value="XM_001227327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRK3"/>
    <dbReference type="STRING" id="306901.Q2GRK3"/>
    <dbReference type="GeneID" id="4394934"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09401"/>
    <dbReference type="eggNOG" id="KOG1460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_3_0_1"/>
    <dbReference type="InParanoid" id="Q2GRK3"/>
    <dbReference type="OMA" id="MPVPNWW"/>
    <dbReference type="OrthoDB" id="285674at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06428">
        <property type="entry name" value="M1P_guanylylT_A_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="10">
        <location>
            <begin position="310"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ85387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="440" mass="48463" checksum="EEAC073C4BE197DF" modified="2006-03-21" version="1">MSLQIPHREKSNGAGGATKAVILVGGASRGTRFRPLSLDVPKPLFDVAGHPIIWHCLTAISKVPSIQEVYLIGYYEESVFRDFIKDAATEFPNIAIKYLREYQALGTAGGLYHFRDAILKGRPEHIFVLNSDVCCSFPLNQMLQLAQEKDAEAVILGTRVSEEAATNFGCIVSDSHTRRVLHYVEKPESHISNLINCGVYLFSADVLFPSIRSAIKRRTDRPRLGSYRSSENLASSFMIDDDENQKNEVIRLEQDILSDMADSKQFFVYETSDFWRQIKTAGSAIPANALYLQKALQSGSKDLAPPSANIIPPVYIHPSAQVHPTAKLGPNVSVGPRATIDAGARVKESIVLEDAEIKHDSCVLYSIIGWSSRVGAWARVEGTPTPVTSHNTSIIKNGVKVQAITILGKECAVGDEIRVQNCVCLPFKELKRDVANEVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRQ0</accession>
    <name>Q2GRQ0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227281.1">
        <property type="nucleotide sequence ID" value="XM_001227280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRQ0"/>
    <dbReference type="STRING" id="306901.Q2GRQ0"/>
    <dbReference type="GeneID" id="4395129"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09354"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_4_1"/>
    <dbReference type="InParanoid" id="Q2GRQ0"/>
    <dbReference type="OMA" id="AMYATSK"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF22">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE PHMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="35616" checksum="F0371FF7A495879F" modified="2006-03-21" version="1">MGLTEALFEAPLQRLAGRFVPGPLPPAGTFDGQTVLIVGATSGLGRAAAVHFATLGANIIITSRVASRADAAKRHIEEAAGPSRKGTISCLELDLERYGSCTSFMAKLKSNLPGPAALDVAIVNGGIVNSHWEQSSHGWEKTIQINTIGTTLMGLLLLGWMRGARDQRASPAHLVFVSSRECFDPDIDQLAKWSQQRGGILRQVSSKENWPSHWWDAEPNYAISKMLLVFAIEEISKLARGPDGDPLVIVNHLCPGMVKTDIGQHIASRSWFHALCTWIVLLITAKSSDSGARILVMAAQKSKETHVRDGFPMQWTNILTMGYDRGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRX7</accession>
    <name>Q2GRX7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227204.1">
        <property type="nucleotide sequence ID" value="XM_001227203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRX7"/>
    <dbReference type="GeneID" id="4395252"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09277"/>
    <dbReference type="HOGENOM" id="CLU_2236308_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRX7"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="105" mass="12082" checksum="1C0D3D994D90EF3F" modified="2006-03-21" version="1">MVGIGFLETICCLRPLPDPPKKRKSKKSKSKKKRESHHQSSKSKGKDKATVDNTDRVEYWVDSQTMITERANRDKQRYAEDEELEARLNNLPHAESSRRAGPSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GS46</accession>
    <name>Q2GS46_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-complex protein 1 subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_09208</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227135.1">
        <property type="nucleotide sequence ID" value="XM_001227134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GS46"/>
    <dbReference type="FunCoup" id="Q2GS46">
        <property type="interactions" value="1179"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GS46"/>
    <dbReference type="GeneID" id="4395692"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09208"/>
    <dbReference type="eggNOG" id="KOG0357">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_2_1"/>
    <dbReference type="InParanoid" id="Q2GS46"/>
    <dbReference type="OMA" id="SHPQMPH"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03339">
        <property type="entry name" value="TCP1_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000053">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000003">
        <property type="entry name" value="T-complex protein 1 subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012718">
        <property type="entry name" value="Chap_CCT_epsi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02343">
        <property type="entry name" value="chap_CCT_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ85194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="529" mass="57459" checksum="1772254D1F3EAAD5" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSQ6</accession>
    <name>Q2GSQ6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PABS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226925.1">
        <property type="nucleotide sequence ID" value="XM_001226924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSQ6"/>
    <dbReference type="GeneID" id="4395302"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08998"/>
    <dbReference type="eggNOG" id="ENOG502QTVA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017511_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GSQ6"/>
    <dbReference type="OMA" id="CFIGWAG"/>
    <dbReference type="OrthoDB" id="2016285at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010487">
        <property type="term" value="F:thermospermine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000288">
        <property type="entry name" value="Spermine/spermidine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037959">
        <property type="entry name" value="MFS_SpdSyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317:SF1">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="62133" checksum="C70DD12C7E50B124" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTB8</accession>
    <name>Q2GTB8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_08786</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226713.1">
        <property type="nucleotide sequence ID" value="XM_001226712.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4395656"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08786"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_23_6_1"/>
    <dbReference type="InParanoid" id="Q2GTB8"/>
    <dbReference type="OMA" id="PSPSEFC"/>
    <dbReference type="OrthoDB" id="4842715at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="4">
        <location>
            <begin position="922"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="815"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1360"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1360"/>
            <end position="1372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ84772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1577" mass="176613" checksum="7F0A46ACEE683225" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTQ4</accession>
    <name>Q2GTQ4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_08650</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226577.1">
        <property type="nucleotide sequence ID" value="XM_001226576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTQ4"/>
    <dbReference type="STRING" id="306901.Q2GTQ4"/>
    <dbReference type="GeneID" id="4395293"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08650"/>
    <dbReference type="eggNOG" id="KOG3013">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034114_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTQ4"/>
    <dbReference type="OMA" id="MEADLNG"/>
    <dbReference type="OrthoDB" id="1650at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05789">
        <property type="entry name" value="S1_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000038">
        <property type="entry name" value="Exosome complex component RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048565">
        <property type="entry name" value="S1_RRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF4">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21266">
        <property type="entry name" value="S1_RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="8">
        <location>
            <begin position="75"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="RRP4 S1" evidence="9">
        <location>
            <begin position="132"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ84636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="324" mass="34427" checksum="C6F78F619F7766E0" modified="2006-03-21" version="1">MPITILPPKPSRPINNNRPSSEDDIYGASDSDSDAGTGGGASIDPDGDHAMLPPTSKRPRHTTTTTTTNPSSSSIVTPGEQITDDPQWMRGHGTYIPSTSTGRAAAGAIVSSVAGTVARTNKLLSVRPLRARYTPEVGDLVVGRIVEVQAKRWRVDVGSTQLAALPLSAINLPGGILRKRTETDELQIRSFFAEGDLLVAEVQQLFGDGGAVLHTRSLKYGKLRNGTPEAEAGAAGITNMEESVSTTMYSSQNDRIEVETMREIARLRGVVTALVENGLRVDEDMVVRGYHEAVEMAMVSVEGSDDTYLGGEKGQQLAAALTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU46</accession>
    <name>Q2GU46_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226435.1">
        <property type="nucleotide sequence ID" value="XM_001226434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GU46"/>
    <dbReference type="GeneID" id="4395114"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08508"/>
    <dbReference type="HOGENOM" id="CLU_1927354_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GU46"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="131" mass="14478" checksum="CF13571FA9ACCEAB" modified="2006-03-21" version="1">MVFGGKEHRMHNQTPPSRRRPGSLRTSHGAGVHDETEVVPHVRVLDHRATKDRLIVSVSGMAPSNPRSPILHTRRAADGRIADLVASTRTLEEGTSWKEMVARLTGFLLVENRAESNDSSAGNEEDHSVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUL2</accession>
    <name>Q2GUL2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_08342</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226269.1">
        <property type="nucleotide sequence ID" value="XM_001226268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUL2"/>
    <dbReference type="GeneID" id="4394781"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08342"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="InParanoid" id="Q2GUL2"/>
    <dbReference type="OMA" id="WFQFYGR"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF29">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="40"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ84328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="532" mass="59819" checksum="DB3DCE230D422CE8" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUN0</accession>
    <name>Q2GUN0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ87071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225980.1">
        <property type="nucleotide sequence ID" value="XM_001225979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUN0"/>
    <dbReference type="GeneID" id="4393895"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08324"/>
    <dbReference type="eggNOG" id="ENOG502RQQT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015848_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GUN0"/>
    <dbReference type="OrthoDB" id="3365211at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021369">
        <property type="entry name" value="DUF2985"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11204">
        <property type="entry name" value="DUF2985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="602" mass="66674" checksum="02EB62911BEB6D13" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-08-21" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUP0</accession>
    <name>H2AZ_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Histone H2A.Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">HTZ1</name>
        <name type="ORF">CHGG_08314</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received. Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins. Required for the RNA polymerase II and SPT15/TBP recruitment to the target genes. Involved in chromosome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2A.Z forms a heterodimer with H2B. H2A.Z associates with the VPS72/SWC2 subunit of the SWR1 chromatin remodeling complex. Also interacts with RBP1/DNA-directed RNA polymerase II largest subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Acetylated once deposited into chromatin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ87061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225970.1">
        <property type="nucleotide sequence ID" value="XM_001225969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUP0"/>
    <dbReference type="SMR" id="Q2GUP0"/>
    <dbReference type="FunCoup" id="Q2GUP0">
        <property type="interactions" value="928"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GUP0"/>
    <dbReference type="GeneID" id="4394136"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08314"/>
    <dbReference type="eggNOG" id="KOG1757">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062828_2_1_1"/>
    <dbReference type="InParanoid" id="Q2GUP0"/>
    <dbReference type="OMA" id="MNKKGAP"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140898">
        <property type="term" value="P:CENP-A eviction from euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000021">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0544">Nucleosome core</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000297721" description="Histone H2A.Z">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="5"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="143" mass="15263" checksum="3CE058AF4188BDDA" modified="2006-03-21" version="1">MAGGKGKSSGGKSSGGKTSGVDGTKKQQSHSARAGLQFPCGRVKRFLKQNTQNKMRVGAKAAVYVTAVLEYLTAEVLELAGNAAKDLKVKRITPRHLQLAIRGDEELDTLIRATIAFGGVLPHINRALLLKVEQKKKAKAIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV63</accession>
    <name>Q2GV63_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_08141</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225797.1">
        <property type="nucleotide sequence ID" value="XM_001225796.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GV63"/>
    <dbReference type="GeneID" id="4394143"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08141"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_227073_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GV63"/>
    <dbReference type="OrthoDB" id="4570782at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030918">
        <property type="entry name" value="PT_fungal_PKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04532">
        <property type="entry name" value="PT_fungal_PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ketoacyl-synt_C"/>
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            <end position="50"/>
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            <begin position="1148"/>
            <end position="1567"/>
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            <begin position="684"/>
            <end position="705"/>
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        <location>
            <begin position="2045"/>
            <end position="2179"/>
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            <begin position="2206"/>
            <end position="2355"/>
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        <location>
            <begin position="2368"/>
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            <begin position="2439"/>
            <end position="2544"/>
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        <location>
            <begin position="2371"/>
            <end position="2382"/>
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            <begin position="2470"/>
            <end position="2483"/>
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            <end position="2518"/>
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            <position position="2267"/>
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        <source>
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        <source>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
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    <sequence length="2748" mass="294937" checksum="30A4B1542BCE0C94" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV85</accession>
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        <recommendedName>
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        </recommendedName>
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            <taxon>Sordariomycetidae</taxon>
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        </lineage>
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            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR37783">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37783:SF1">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF2470"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="166"/>
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            <end position="606"/>
        </location>
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        <location>
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        <location>
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        <location>
            <begin position="481"/>
            <end position="490"/>
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    </feature>
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        <source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="606" mass="66154" checksum="992EDA2B6B30BB8E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVF9</accession>
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        <recommendedName>
            <fullName evidence="2">MINDY deubiquitinase domain-containing protein</fullName>
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        <name evidence="3" type="ORF">CHGG_08045</name>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001225700.1"/>
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    <dbReference type="eggNOG" id="KOG2427">
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    <dbReference type="HOGENOM" id="CLU_007080_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GVF9"/>
    <dbReference type="OMA" id="NNAWASA"/>
    <dbReference type="OrthoDB" id="10261212at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016807">
        <property type="term" value="F:cysteine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR033979">
        <property type="entry name" value="MINDY_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063">
        <property type="entry name" value="NF-E2 INDUCIBLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04424">
        <property type="entry name" value="MINDY_DUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="363"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="298"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="804"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ86792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="854" mass="91681" checksum="00718490DB2982DB" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWC8</accession>
    <name>Q2GWC8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spo12-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225382.1">
        <property type="nucleotide sequence ID" value="XM_001225381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWC8"/>
    <dbReference type="STRING" id="306901.Q2GWC8"/>
    <dbReference type="GeneID" id="4393353"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07726"/>
    <dbReference type="eggNOG" id="ENOG502SBH5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132226_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GWC8"/>
    <dbReference type="OMA" id="TKSMEYH"/>
    <dbReference type="OrthoDB" id="5578329at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007727">
        <property type="entry name" value="Spo12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05032">
        <property type="entry name" value="Spo12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13187" checksum="511FC392E7E69CCD" modified="2006-03-21" version="1">MSSANVLAARDVNTSMPAHGQNHTETDGNTKPDVMSMEHHRQVFQSKMEQGENKTFISPSDTIMSPCTAKLSAFRNKQVGKGKPKSLFARASAKKLGADGGSNGGPLFASKPATTAQHDNPFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWK9</accession>
    <name>Q2GWK9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ketosynthase family 3 (KS3) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_07645</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2015" name="J. Am. Chem. Soc." volume="137" first="9885" last="9893">
            <title>Biochemical and structural basis for controlling chemical modularity in fungal polyketide biosynthesis.</title>
            <authorList>
                <person name="Winter J.M."/>
                <person name="Cascio D."/>
                <person name="Dietrich D."/>
                <person name="Sato M."/>
                <person name="Watanabe K."/>
                <person name="Sawaya M.R."/>
                <person name="Vederas J.C."/>
                <person name="Tang Y."/>
            </authorList>
            <dbReference type="PubMed" id="26172141"/>
            <dbReference type="DOI" id="10.1021/jacs.5b04520"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) OF 2-378</scope>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225301.1">
        <property type="nucleotide sequence ID" value="XM_001225300.1"/>
    </dbReference>
    <dbReference type="PDB" id="4RO5">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.60 A"/>
        <property type="chains" value="A=1-378"/>
    </dbReference>
    <dbReference type="PDB" id="4RPM">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.40 A"/>
        <property type="chains" value="A=2-378"/>
    </dbReference>
    <dbReference type="PDBsum" id="4RO5"/>
    <dbReference type="PDBsum" id="4RPM"/>
    <dbReference type="AlphaFoldDB" id="Q2GWK9"/>
    <dbReference type="SMR" id="Q2GWK9"/>
    <dbReference type="STRING" id="306901.Q2GWK9"/>
    <dbReference type="GeneID" id="4393766"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07645"/>
    <dbReference type="HOGENOM" id="CLU_000022_6_3_1"/>
    <dbReference type="InParanoid" id="Q2GWK9"/>
    <dbReference type="OMA" id="AREDITW"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q2GWK9"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF14">
        <property type="entry name" value="ITERATIVE POLYKETIDE SYNTHASE AFOE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9 10" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="6">
        <location>
            <begin position="405"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="364"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ86392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="4RO5"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="4RPM"/>
        </source>
    </evidence>
    <sequence length="1184" mass="127413" checksum="035C90157CD0099F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWV7</accession>
    <name>Q2GWV7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_07547</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225203.1">
        <property type="nucleotide sequence ID" value="XM_001225202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWV7"/>
    <dbReference type="STRING" id="306901.Q2GWV7"/>
    <dbReference type="GeneID" id="4393291"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07547"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_1_2_1"/>
    <dbReference type="InParanoid" id="Q2GWV7"/>
    <dbReference type="OMA" id="QTWWDTT"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF54">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208689" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="18"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ86294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="52144" checksum="0E1DC48092AB2F1C" modified="2006-03-21" version="1">MLRPWPILLGLALPAAATTTNHNHDHSTICQTLAHTHPHLTITLPSSPLYPTHNTYWSARQSALHPACFITPTNTTEVAQTIRFLTTHRAPFSIKGGGHTAFGGQTHALLDRMGCDWIPPEQAVTSQRSSLGWGERGCALGGGISYFSGGRGWVCDNVRRYEVVLASGEVVEASAGVNGDLYWALRGGGGSNFGVVTRFDLVAFEQGDLWASSRVYPGAATNRTLIPLMHELLVKGLADDHAAHTYFVMTYAAELGGYVVLSDQFHATHSDLASPPAVFAEFHNTVLPTLSTNTRLSNVSRLSRDIEQAPGLRQTWWVTSVAATATPDLLLDIVPLWEKYVARLLAAAAADNSTVSPFLIYQPISSNILEAMQVNGGNALGLKPEDGPLMIVQLALSWTSTGMDAAVETGSKELIDKINALAESRGARSKNGYIYMNYAGQTQDVFAGYGKQNHAKLRRVAKKYDPRGELRDLWKGYFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX10</accession>
    <name>Q2GX10_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_07494</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225150.1">
        <property type="nucleotide sequence ID" value="XM_001225149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX10"/>
    <dbReference type="GeneID" id="4394622"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07494"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_5_1"/>
    <dbReference type="InParanoid" id="Q2GX10"/>
    <dbReference type="OMA" id="RFNQDMD"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002145">
        <property type="entry name" value="ABC transporter (MsbA subfamily)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF404">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="550"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="634"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="261"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="511"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="727"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="969"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ86241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="995" mass="108353" checksum="5D90C5CFA79BB43D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX36</accession>
    <name>Q2GX36_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_07468</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225124.1">
        <property type="nucleotide sequence ID" value="XM_001225123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX36"/>
    <dbReference type="GeneID" id="4393387"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07468"/>
    <dbReference type="eggNOG" id="ENOG502T4N2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097613_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GX36"/>
    <dbReference type="OMA" id="WGYVNFT"/>
    <dbReference type="OrthoDB" id="3539798at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032382">
        <property type="entry name" value="AltA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16541">
        <property type="entry name" value="AltA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208699" description="AA1-like domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="AA1-like" evidence="6">
        <location>
            <begin position="50"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ86215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="195" mass="21687" checksum="02ABA3190B939349" modified="2006-03-21" version="1">MYFRTPFVVLSLLALASASPVPSPGPAEGAKSPAGCSDTSFKKFTWTAKNFDFHASYIFTTPAHQNSWGYVSFDLYNPGDQTTAHCEGASNQLSDFFYGTVPYKCNDTERIGETKFDFARPTNQLRVNQTWTCDDNDPQYPTTFTGRGSIDLPLDCKDQTWKNPDWEMGQIYSSRTITCAPVESTIKPNELSAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXY9</accession>
    <name>Q2GXY9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_07165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224821.1">
        <property type="nucleotide sequence ID" value="XM_001224820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXY9"/>
    <dbReference type="FunCoup" id="Q2GXY9">
        <property type="interactions" value="746"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GXY9"/>
    <dbReference type="GeneID" id="4393565"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07165"/>
    <dbReference type="eggNOG" id="KOG1104">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013816_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GXY9"/>
    <dbReference type="OMA" id="CAAEGLM"/>
    <dbReference type="OrthoDB" id="10252707at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000079">
        <property type="entry name" value="Related to cap binding protein 80 (Cbp80)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000035">
        <property type="entry name" value="snRNA cap binding complex subunit (Gcr3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000045">
        <property type="entry name" value="snRNA cap binding complex subunit (Gcr3), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027159">
        <property type="entry name" value="CBP80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015172">
        <property type="entry name" value="MIF4G-like_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015174">
        <property type="entry name" value="MIF4G-like_typ-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412">
        <property type="entry name" value="CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412:SF2">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09088">
        <property type="entry name" value="MIF4G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09090">
        <property type="entry name" value="MIF4G_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G-like type 1" evidence="2">
        <location>
            <begin position="312"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G-like type 2" evidence="3">
        <location>
            <begin position="539"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="791"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ85912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="820" mass="91057" checksum="D3F9A5496CDFE006" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GY12</accession>
    <name>Q2GY12_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_07142</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224798.1">
        <property type="nucleotide sequence ID" value="XM_001224797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GY12"/>
    <dbReference type="STRING" id="306901.Q2GY12"/>
    <dbReference type="GeneID" id="4393512"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07142"/>
    <dbReference type="eggNOG" id="ENOG502QTW1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027360_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GY12"/>
    <dbReference type="OMA" id="LWEGWRD"/>
    <dbReference type="OrthoDB" id="5356836at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF5">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ85889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="419" mass="46225" checksum="254DFD5B6F067761" modified="2006-03-21" version="1">MPSPDKTIAVINASGRQAASFIRVASAVGYHVRAQLRNLEGVVATEVSTNPNVTVLQGELYTKERPAETAKVDVTRNGPISGIGINHALISELFRGAQLAFINTTFYGDEQHIGEALADAAKRAGIQHYVYSSMPDHHAYNKEWPSLPLWASKHKVEEYVKKIGLPATFVYTGIYNNNFTSLPYPLFCTDLQEDGSWIWQAPFHPDVKLPWLDAEHDVGPAILQIFKDGVKKWGGGKRVGLAYEMLSPKEACEVFSRGVGRPVRYVHGPIELKVTIPEGYRAQLEALEALFGMGHDDPTKQPPYFGDAALEESCPRVALELWEGPRGLEEYAREVFPLEEQANGLTWMLDEGDGGGGGNHVHRNGNGVATGHAPHSHDVHHLNGYITTLQQVTLESDGEDEDDGLVMRGLKRDDEEWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GY70</accession>
    <name>Q2GY70_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Interferon-related developmental regulator N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_07084</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IFRD family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224740.1">
        <property type="nucleotide sequence ID" value="XM_001224739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GY70"/>
    <dbReference type="STRING" id="306901.Q2GY70"/>
    <dbReference type="GeneID" id="4393825"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07084"/>
    <dbReference type="eggNOG" id="KOG2842">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039188_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GY70"/>
    <dbReference type="OMA" id="HISGRHI"/>
    <dbReference type="OrthoDB" id="18978at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039777">
        <property type="entry name" value="IFRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007701">
        <property type="entry name" value="Interferon-rel_develop_reg_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354:SF1">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05004">
        <property type="entry name" value="IFRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Interferon-related developmental regulator N-terminal" evidence="3">
        <location>
            <begin position="76"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ85831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="450" mass="49578" checksum="EFA3DAEA15E7BEB4" modified="2006-03-21" version="1">MSELRRRALGSGKTVSRKARLKPESGLSSTNHSPNGSPANSRVGSRANSRPGSRYASEDEFASDSENDDIMTMSANSVDGDEDVGSTTTWVERLQDRVTELQDRKRSSVQGREATLGGYNHLLKHHFAQGQLQRSVAEIMPVLLRDVKNGSSDEERLRALKAFTLTVLTCSSDTVFEQALPILKAACHDSEEEDNKIEAIHALSIAVTYGGGSTEAAEEVLDFLLEIIESDGHSVTAADSAPVVTAALQAWAFVASHLDDLTDQSETAIEAFMEQLDSSDPDVQTGAGVNIALLFEAARDYEEETGQSFDMQYNQHRIMTRMAEIVRDSSKTISKKGRRNLRSNFSSIVTSLERGKGPGYSTAGRSGPNPHTGGSRTDDQSDFREFGYREKIRIYNQFLLIDTWSLHTRVELLKILLGGGFGIHYLENPVIRDILSSAEVEFISERRPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYA3</accession>
    <name>Q2GYA3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224707.1">
        <property type="nucleotide sequence ID" value="XM_001224706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYA3"/>
    <dbReference type="GeneID" id="4394644"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07051"/>
    <dbReference type="eggNOG" id="ENOG502SVIN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136305_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GYA3"/>
    <dbReference type="OMA" id="VSSQQGY"/>
    <dbReference type="OrthoDB" id="3913483at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="89" mass="9207" checksum="4B1DC6BFB9B677FC" modified="2006-03-21" version="1">MSESKTDKIDRVKANLPLPEQPPVPGDMKSANMKTTSSTGVSAGDVSTGPGVTSGLREPASKDSSDIDMSGIGRQGKEGLEHPPKDARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYH1</accession>
    <name>Q2GYH1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DnaJ-related protein SCJ1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_06983</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224639.1">
        <property type="nucleotide sequence ID" value="XM_001224638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYH1"/>
    <dbReference type="FunCoup" id="Q2GYH1">
        <property type="interactions" value="415"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GYH1"/>
    <dbReference type="GeneID" id="4393240"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06983"/>
    <dbReference type="eggNOG" id="KOG0712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_0_2_1"/>
    <dbReference type="InParanoid" id="Q2GYH1"/>
    <dbReference type="OMA" id="KWHEDGD"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208730" description="DnaJ-related protein SCJ1" evidence="8">
        <location>
            <begin position="21"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="23"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="10">
        <location>
            <begin position="148"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="148"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ85730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="47284" checksum="387DFF540B817BB1" modified="2006-03-21" version="1">MRLLKTILLPLLALAQAALCAEDYYKVLGLDKQASDRQIKSAYRQLSKKYHPDKNPNDSTAHDKFVLVAEAYEALSDAESRQIYDQYGYDALKQRKQQGGGGGGGHDPFDLFSRFFGGGGHYGSQPGQRRGHNVEVKVPVALRDFYNGRTTEFQWNKQEICEECEGTGAADRVVHACTACAGRGVRTVRQQLAPGMVTQVQMQCDACGGRGKSIKHRCKACGGERVVRRPATVSLTVQRGMADGVRIAYENEADASPDYVAGDLIVQVVEKEPELEGEESNPDRVDGVFFRRKEDDLFWREVLSLREALMGGWTRNVTHLDGHVVRLGRERGVVVQPNHVETVPGEGMPKWHEDGDSVYHKTEFGNLYVEYTVVLPDQMDSGMEKDLWAVFEKWRAKNGIDLHKDSGRPDKPVMHDHEHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYI3</accession>
    <name>Q2GYI3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_06971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224627.1">
        <property type="nucleotide sequence ID" value="XM_001224626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYI3"/>
    <dbReference type="STRING" id="306901.Q2GYI3"/>
    <dbReference type="GeneID" id="4393868"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06971"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_6_21_1"/>
    <dbReference type="InParanoid" id="Q2GYI3"/>
    <dbReference type="OMA" id="HARMAHT"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031352">
        <property type="entry name" value="SesA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17107">
        <property type="entry name" value="SesA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="197"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ85718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="580" mass="64568" checksum="C6BAF92FEB3A046D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYQ3</accession>
    <name>Q2GYQ3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224557.1">
        <property type="nucleotide sequence ID" value="XM_001224556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYQ3"/>
    <dbReference type="GeneID" id="4393533"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06901"/>
    <dbReference type="eggNOG" id="ENOG502RN1R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025401_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYQ3"/>
    <dbReference type="OMA" id="AVYIQHQ"/>
    <dbReference type="OrthoDB" id="10062838at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="384" mass="41564" checksum="49442DE26E9E2143" modified="2006-03-21" version="1">MRSRSPTHTTAAAARAEASRKYTLSAIFLVVSLVSFTAQTILASHIQHDLGWDKAYCMLYLTHGSWALLWPLQLLVLRTQRPGRDRSWGRFWDGHLRTVRGIALVVETRDVKAGVHAAQHGGGLLEYGHSPWPYLGKTTAVITSALTVAGLSWYLAVSMTTPSDLTAIYNCSAFFAYAFSVPLLKEKLRADKMLAVAVAIVGVLVVAYGDGAGDGSSEEASAVPGGGGVVVDPGTRFAGKHDHRRGGVIFANTFGSLMGAFTLFVLWIPIPVLHVLGWETFVIPTGETAWLLFISVIMNMLFSGSFLVLISLTSPVLSSVASLLTIFMVAIVDWFVTGTPLSGAAMFGGLLIVIAFAMLSWSTWREMNEEEHRKQVDLSGDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYT5</accession>
    <name>Q2GYT5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_06869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224525.1">
        <property type="nucleotide sequence ID" value="XM_001224524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYT5"/>
    <dbReference type="GeneID" id="4394094"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06869"/>
    <dbReference type="HOGENOM" id="CLU_2249825_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYT5"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ85616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="104" mass="11433" checksum="E6BF9B155432D16B" modified="2006-03-21" version="1">MEIARGRKLHLLEKSILPTGTCYAQLSAHEPHVPQTSPPCVAQKPGQALMKGAQQMRKGQSASLKRDASRDRDRWAANTPGVLLARFLGTETPGWSHEDFTLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYY3</accession>
    <name>Q2GYY3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_06821</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224477.1">
        <property type="nucleotide sequence ID" value="XM_001224476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYY3"/>
    <dbReference type="STRING" id="306901.Q2GYY3"/>
    <dbReference type="GeneID" id="4393262"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06821"/>
    <dbReference type="eggNOG" id="KOG1712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003324_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYY3"/>
    <dbReference type="OMA" id="GKDYCAE"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005919">
        <property type="entry name" value="Pmev_kin_anim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF25">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04275">
        <property type="entry name" value="P-mevalo_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="276"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ85568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1109" mass="120306" checksum="449EDC9838CEE2CE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYY5</accession>
    <name>Q2GYY5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224475.1">
        <property type="nucleotide sequence ID" value="XM_001224474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYY5"/>
    <dbReference type="STRING" id="306901.Q2GYY5"/>
    <dbReference type="GeneID" id="4392106"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05261"/>
    <dbReference type="HOGENOM" id="CLU_001104_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GYY5"/>
    <dbReference type="OrthoDB" id="5244177at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022698">
        <property type="entry name" value="OrsD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12013">
        <property type="entry name" value="OrsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="393" mass="42174" checksum="954A780DFB500327" modified="2006-03-21" version="1" fragment="single">MATFSELFTPLPAFRTAVCHEHGIVVTARSVASHVNSRHRHLAARVRQRIMAEALALRDDGSLAADTNNIRFPDEVIPAIDGLPVWSDGKKCIECGYIQRGRKHIQKHCRSEHGWTNPRKRGGKPGAQQAGGLGEVWVDGVHCQRFGQAGVLQRLFEVTTPAHAGASGSRGETADFEAAIRAEFEAAARAIKEKDEAAAALIGDQSRLSANMWVGRTGWPRHLRGFDREWLATTILAARGGEGGRSRGGGLGRGTGRGGGEDGEAGEEVGGQGGDRNRDGRARSEAALAVVLLAVERVIWRAQKASQVEVVGSASVNYIERREVGGEANEKPFNAAQKGTTMAKYSESWKLLMAYLWRTWRLEPVDQGDEDEGEEGGGGGEGGGGEEDNGHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZ14</accession>
    <name>Q2GZ14_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_05232</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224446.1">
        <property type="nucleotide sequence ID" value="XM_001224445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZ14"/>
    <dbReference type="FunCoup" id="Q2GZ14">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GZ14"/>
    <dbReference type="GeneID" id="4393107"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05232"/>
    <dbReference type="eggNOG" id="KOG1842">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026440_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GZ14"/>
    <dbReference type="OMA" id="DDVHQNL"/>
    <dbReference type="OrthoDB" id="166134at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15761">
        <property type="entry name" value="FYVE1_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15737">
        <property type="entry name" value="FYVE2_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.20">
        <property type="entry name" value="Rabenosyn, Rab binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021565">
        <property type="entry name" value="Rbsn_Rab-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11464">
        <property type="entry name" value="Rbsn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="9">
        <location>
            <begin position="200"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="9">
        <location>
            <begin position="338"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="546"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="602"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="24"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="546"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ88613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="677" mass="75193" checksum="E2D02647430DADC6" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZ63</accession>
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        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_05183</name>
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    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224397.1">
        <property type="nucleotide sequence ID" value="XM_001224396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZ63"/>
    <dbReference type="GeneID" id="4392275"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05183"/>
    <dbReference type="eggNOG" id="KOG4177">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_2_1"/>
    <dbReference type="InParanoid" id="Q2GZ63"/>
    <dbReference type="OMA" id="NVDCSYR"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
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    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
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    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="464"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="4">
        <location>
            <begin position="593"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="810"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="564"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ88564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="938" mass="103889" checksum="FF8D6FF604941972" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZH2</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="6">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_05074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224288.1">
        <property type="nucleotide sequence ID" value="XM_001224287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZH2"/>
    <dbReference type="FunCoup" id="Q2GZH2">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GZH2"/>
    <dbReference type="GeneID" id="4392273"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05074"/>
    <dbReference type="eggNOG" id="ENOG502QTER">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014123_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZH2"/>
    <dbReference type="OMA" id="YQKCIKY"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="328"/>
        </location>
    </feature>
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        <location>
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            <end position="550"/>
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            <end position="232"/>
        </location>
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        <location>
            <begin position="259"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ88455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="73833" checksum="CC9FC6584598922A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="FORMYLMETHIONINE DEFORMYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="197"/>
        </location>
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            <end position="234"/>
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            <end position="298"/>
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            <end position="77"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="EAQ88324.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
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            <authorList>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ88308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="275" mass="30172" checksum="128537A70B08FCA0" modified="2006-03-21" version="1">MTVANLYYLFLWQEPRIPQLPQLPHMDEQPYRLGMASIAYCGQPIGNTACCTAQPRRFHHQPYRTLSNPIKPHPGAWDAAACSKSSGDAQPHQPLTIHAEAAAKTRAIRIGPRAQERRKEQRGNRRKEKVWAPSHHSRHVVSCCITSPTAAFPGEKGDNSEEWHNGQGDLEGVRGRGSRRRGTPSRAEQVRPPASRRTGGAKRGEQGRHGMPRLGAKRDDLAAHSLRGLRPIIAPPGTGLTKTNNPQAAPRSQRTTPSEPTNVPSPPRCSLSVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H010</accession>
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        </submittedName>
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        <name evidence="2" type="ORF">CHGG_04886</name>
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        <lineage>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="215" mass="23796" checksum="370F41190FCA29E7" modified="2006-03-21" version="1">MTAEREKKATTQKAENELNICSGPRKLGRRRQTRQMHLASSMGLPSMEPWMVDGGGSARPSSADGCRSTADEPLPNTPNIPLRGPFEEGELNHSAGTWRQLERAQQLGAALPATRVSVLAPAKAQQRRWVSNICQLQEERSGSPQYQMRGRIRCVCAAMERAGCGKSGSMESEQQRGTRARRAPELESLVRAEFIPINPLTRHQLPMYPHRAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H069</accession>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
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    </dbReference>
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    <dbReference type="STRING" id="306901.Q2H069"/>
    <dbReference type="GeneID" id="4393016"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04827"/>
    <dbReference type="eggNOG" id="KOG0003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175093_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H069"/>
    <dbReference type="OMA" id="KGATNCR"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.50:FF:000001">
        <property type="entry name" value="ubiquitin-60S ribosomal protein L40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_eL40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="Ribosomal_eL40_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL40" evidence="5">
        <location>
            <begin position="23"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ88208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="74" mass="8556" checksum="B8DA71127F5681CF" modified="2006-03-21" version="1">MLIPDTRPQESTLHLVLRLRGGIIEPSLKALASKFNCEKMICRKCYARLPPRATNCRKRKCGHTNQLRPKKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0B9</accession>
    <name>Q2H0B9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_04777</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223991.1">
        <property type="nucleotide sequence ID" value="XM_001223990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0B9"/>
    <dbReference type="GeneID" id="4391526"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04777"/>
    <dbReference type="eggNOG" id="ENOG502SS51">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054422_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H0B9"/>
    <dbReference type="OMA" id="NTRIATW"/>
    <dbReference type="OrthoDB" id="3547571at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209162" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ88158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="38515" checksum="2CE6116A61A10BB2" modified="2006-03-21" version="1">MAMFPLLLLLLLSSVQEVTASALLGRQWPSSDGGTAMEFNKPGGSSIFTTYSVIYRDGDASRRRTAESGYDIRVDVVNSAWAFCRSNDPSLCDMGGACFDKFSCSTGLPENEHEPTRYSAGSKARYCSTDLLTLSRDSPRAVTYLAYGDRPDRTQEYKVFTTNAKPSASSSSAPKPLPTPPQTSQIATAGTSPSQAAAQTAASTESANNDDNNDNSDTNDTNNSSNAGNTSNTNDTDDTNDTNNTDNTNNTDSNTNTSNSTNTAMTVGAAVGCVALICIFVVVVFLIRRTRATSAATAATTPTTMGEATTDGAAVASAQGLYKPPLGELDGERGVYEIGQGCPVTPPVELPGTRWESTEVPTKSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0V3</accession>
    <name>Q2H0V3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_04593</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223807.1">
        <property type="nucleotide sequence ID" value="XM_001223806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0V3"/>
    <dbReference type="STRING" id="306901.Q2H0V3"/>
    <dbReference type="GeneID" id="4392746"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04593"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1562705_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H0V3"/>
    <dbReference type="OMA" id="GIENDHA"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF43">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="67"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ87974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="171" mass="18039" checksum="EA74EA2B96DE220E" modified="2006-03-21" version="1">MEKNSPSRDSPLEAADKLDHDEKQPSNPTQTPINPPEETPAGALSDSTTDEKHLGPQSIPRLRFIALSTGVALGLFLSMLDSSIVATSLFTIAAEFGDVDSINWVALAYTLTYLSCAVLFARVSDVVGRHAAFAAAYVVFIVFSIACGFASGMGQLIAFRALQGVGGSACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H151</accession>
    <name>Q2H151_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_04495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223709.1">
        <property type="nucleotide sequence ID" value="XM_001223708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H151"/>
    <dbReference type="GeneID" id="4392152"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04495"/>
    <dbReference type="HOGENOM" id="CLU_927498_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H151"/>
    <dbReference type="OrthoDB" id="4577776at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ87876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="300" mass="32995" checksum="D13B41ED8E838C07" modified="2006-03-21" version="1">MFDSPYMYPPQRYLPAKATGSDSSDAGNFNISSVRLRVGAPPPMGLPLNNEWNAQCSLISDELGRGVLESETKKILSAEGVTDVISVELTPRDVELTCQEGRPTIFIVARWEDGYSDLWEAVVRKVKKLVDSKRLTSEKLGDIDITVEMIAEELTLKKYMSAIPEEILAGGLERDCPGIKSRVIEILDSHSATKGMGEITLCKLGFSPQDSENPDTVYVSTDYESDESKWPPIMEEIKQYLKEVDYAQLHVQFEHGMSDALLGLQQVSKEPMCSGKEGKENGGGNLSRGIEGLSPLFAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H175</accession>
    <name>Q2H175_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223685.1">
        <property type="nucleotide sequence ID" value="XM_001223684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H175"/>
    <dbReference type="FunCoup" id="Q2H175">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H175"/>
    <dbReference type="GeneID" id="4392357"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04471"/>
    <dbReference type="eggNOG" id="ENOG502RNIV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_698261_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H175"/>
    <dbReference type="OMA" id="QNAYANV"/>
    <dbReference type="OrthoDB" id="2527403at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018803">
        <property type="entry name" value="Ish1/Msc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10281">
        <property type="entry name" value="Ish1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209183" evidence="1">
        <location>
            <begin position="20"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="397" mass="44475" checksum="1605601A587EABA3" modified="2006-03-21" version="1">MRIAKTLLPLALVANAAVASSWFSNAAYNKWHETELERWLSDHDVPYPTPADRKDLEQLVQKNWDANVVEPYNKWDTAKLTDYLKVKGVETKESAEETRESLLARVKSSWYESEEKTQNAYANVKDRILDTWTDSQLKAFCDRHGIPVPQPRKRDTLLQKVRENYEAVAQKAGEAAAYPRNWLYETWTGYLDARGVPVPQGSKTDELRALVRKHSHKAASGWTAWTWDDLSLDNIRGYIASSGNAAAKKVSDKTSATRDELVDAAQSAYLSASSAGGGSYASATSFLTKATDTTKAGLFDTWSESELKAYLDSYGIPAPQGSEINELRALARRQYTYFKYGTTSPTETLFAKVRENVQSGWDWVAGQLRLGSDAAKKKAEEAEAEGRRKAEKLHKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1L9</accession>
    <name>Q2H1L9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223541.1">
        <property type="nucleotide sequence ID" value="XM_001223540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1L9"/>
    <dbReference type="STRING" id="306901.Q2H1L9"/>
    <dbReference type="GeneID" id="4391683"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04327"/>
    <dbReference type="eggNOG" id="ENOG502SR3T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133415_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H1L9"/>
    <dbReference type="OMA" id="GMYNCAG"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208816" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="59"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="168" mass="17848" checksum="DFE120B199690AD0" modified="2006-03-21" version="1">MLGTSVVLLALAAVGLAQVPEGYRAVYITSNVDPKFVIVAKARTTGSTTIVQTRKSTPEQQWYLKDGATKIQLAGTTLCMDGGAKANWKDMGNIYVNECAETESQNWFVMADGRIALEPSGQKQCVDLVYMRAVENNAVGLYSCAGLGNTGAADKGINWPLVNATAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1U4</accession>
    <name>Q2H1U4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Defects in morphology protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_04252</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EXO5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223466.1">
        <property type="nucleotide sequence ID" value="XM_001223465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1U4"/>
    <dbReference type="GeneID" id="4391780"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04252"/>
    <dbReference type="eggNOG" id="KOG4760">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013225_1_2_1"/>
    <dbReference type="InParanoid" id="Q2H1U4"/>
    <dbReference type="OMA" id="VAVEFRY"/>
    <dbReference type="OrthoDB" id="354769at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045145">
        <property type="term" value="F:single-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019190">
        <property type="entry name" value="EXOV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464:SF4">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09810">
        <property type="entry name" value="Exo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="24"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="481"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="624"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="445"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="633"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="656"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="678"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ87633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="723" mass="80278" checksum="099D2E4539DAA779" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2V5</accession>
    <name>Q2H2V5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_03891</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223105.1">
        <property type="nucleotide sequence ID" value="XM_001223104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2V5"/>
    <dbReference type="STRING" id="306901.Q2H2V5"/>
    <dbReference type="GeneID" id="4391599"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03891"/>
    <dbReference type="eggNOG" id="KOG1032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006864_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2V5"/>
    <dbReference type="OMA" id="PSGNMIS"/>
    <dbReference type="OrthoDB" id="2162691at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
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    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="988"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="8">
        <location>
            <begin position="754"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="329"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="405"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="641"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="928"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="644"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="672"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="936"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ87272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1113" mass="119566" checksum="5343F323D48E3AB6" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3V0</accession>
    <name>Q2H3V0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_06665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lunapark family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222760.1">
        <property type="nucleotide sequence ID" value="XM_001222759.1"/>
    </dbReference>
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    <dbReference type="STRING" id="306901.Q2H3V0"/>
    <dbReference type="GeneID" id="4391475"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06665"/>
    <dbReference type="eggNOG" id="KOG2846">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039522_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H3V0"/>
    <dbReference type="OMA" id="CGYFNPS"/>
    <dbReference type="OrthoDB" id="1725934at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="3">
        <location>
            <begin position="256"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ90046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="381" mass="42191" checksum="45D8A867175BFA4E" modified="2006-03-21" version="1">MVSFWPWGKDDSSPASFEKALSALSAKITTTQTRLDQDRAKSRRIKLLCSLYLGFAYLVYGIVLVLVVGWRYMGAWEWTGIAGGPVLITLVRAAVTTFFDYRIQRRSVRLKEYQTERAKTIQKLKDATKYDSTLELLEKYGETENKQKRGKKTTDGSDPAEQNNEGQSKAKDSGMPQRTNMPPPPTANIQRPHIPRPGTPQSRPHSRLGTPSQHQTRQSDMDASAEFAPNAFDGRPAPAFMQYPPAAMAPPAESHWYDRILDTLLGEDETAAKNRIVLMCSSCRLVNGQAPPGTKSLSELGMWKCMACGASNGELDEGKRLVQEALGRRNLPDLKVESIDDSASRSSSDLVEVEKDISDVEAEGKGVVTDGPRKRRGKGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3X3</accession>
    <name>Q2H3X3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_06642</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="8"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222737.1">
        <property type="nucleotide sequence ID" value="XM_001222736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3X3"/>
    <dbReference type="FunCoup" id="Q2H3X3">
        <property type="interactions" value="393"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H3X3"/>
    <dbReference type="GeneID" id="4391507"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06642"/>
    <dbReference type="eggNOG" id="KOG3396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072095_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H3X3"/>
    <dbReference type="OMA" id="NQRYDWI"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000048">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ90023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="178" mass="19968" checksum="19B111D3964B850F" modified="2006-03-21" version="1">MAEQALFSAQYLSPEVQAALPEGYKLRPLRRDDFDAGFLDCLRVLTTVGEISKERWEERYDWISKQDGTYFILVIEDTTANPPRIVGTGALLVERKFIHNLGAVGHIEDIAVAKDQQGKKLGLRLIQALDYIAKQVGCYKTILDCSEANEGFYVKCGFRRAGLEMAHYHEGPKSNGAQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-04-03" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H454</accession>
    <name>MET3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP-sulfurylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Sulfate adenylate transferase</fullName>
            <shortName evidence="1">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MET3</name>
        <name type="ORF">CHGG_06561</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>sulfate + ATP + H(+) = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Allosterically inhibited by 3'-phosphoadenosine 5'-phosphosulfate (PAPS).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer. Dimer of trimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The adenylyl-sulfate kinase (APS kinase) is non-functional. It is involved in allosteric regulation by PAPS. PAPS binding induces a large rotational rearrangement of domains lowering the substrate affinity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the APS kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="1"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222656.1">
        <property type="nucleotide sequence ID" value="XM_001222655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H454"/>
    <dbReference type="SMR" id="Q2H454"/>
    <dbReference type="FunCoup" id="Q2H454">
        <property type="interactions" value="520"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H454"/>
    <dbReference type="GeneID" id="4391194"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06561"/>
    <dbReference type="eggNOG" id="KOG0636">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022950_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H454"/>
    <dbReference type="OMA" id="MEMRYAG"/>
    <dbReference type="OrthoDB" id="468at2759"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010134">
        <property type="term" value="P:sulfate assimilation via adenylyl sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.400.10:FF:000003">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000802">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000052">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.10">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03106">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027535">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050512">
        <property type="entry name" value="Sulf_AdTrans/APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004040">
        <property type="entry name" value="PRK05537.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700:SF1">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0021">Allosteric enzyme</keyword>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0486">Methionine biosynthesis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000283681" description="Sulfate adenylyltransferase">
        <location>
            <begin position="1"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Catalytic" evidence="1">
        <location>
            <begin position="170"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric regulation domain; adenylyl-sulfate kinase-like" evidence="1">
        <location>
            <begin position="395"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="197"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="291"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="434"/>
            <end position="437"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="477"/>
            <end position="478"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="site" description="Induces change in substrate recognition on ATP binding" evidence="1">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03106"/>
        </source>
    </evidence>
    <sequence length="573" mass="64156" checksum="2663926BD82C03AB" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4G8</accession>
    <name>Q2H4G8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_06447</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222542.1">
        <property type="nucleotide sequence ID" value="XM_001222541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4G8"/>
    <dbReference type="STRING" id="306901.Q2H4G8"/>
    <dbReference type="GeneID" id="4391149"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06447"/>
    <dbReference type="eggNOG" id="ENOG502RXHJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009769_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H4G8"/>
    <dbReference type="OMA" id="TCSCICT"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17178">
        <property type="entry name" value="SECRETORY GRANULE PROTEOGLYCAN CORE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17178:SF0">
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    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="491"/>
            <end position="517"/>
        </location>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="863" mass="90708" checksum="578C3444E46451DD" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4V1</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="508"/>
        </location>
    </feature>
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        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
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            <end position="101"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="221"/>
        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ89695.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H598</accession>
    <name>Q2H598_CHAGB</name>
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        <recommendedName>
            <fullName evidence="3">Argininosuccinate synthase</fullName>
            <ecNumber evidence="2">6.3.4.5</ecNumber>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="13 14">
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
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    </dbReference>
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    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:argininosuccinate synthase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Arginosuc_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginosuccinate synthase-like N-terminal" evidence="11">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Arginosuccinate synthase C-terminal" evidence="12">
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            <begin position="170"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ89548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="407" mass="44882" checksum="ED505CBCA7EEA882" modified="2006-03-21" version="1">MAAKRVCLAYSGGLDTSVILAWLIEQGYTVVAFLADVGQNEDYDAVKAKAEKIGAERMIIQNLQQELVEELVWPAVQCSFGRPRAKCTTPAHGYSDIPSRCDSSWPGRLSIKRRRRSSRGAYRSSTSDSRPCPCHPPSLGDADPDSGRQALLDFAEAKGVPVTSTKQKPFSMDANLIHCSYEAGMLEQPELEAPADMWTMTVDPMKAPDEPTRFTVHFEKGIPIKLEVGDKTITGSLEIFKAANEIGRANGVGRVDIVESRFIGLKSRGCYDTPGLTILRTAHRDLEGLCMDSKVRAIRDQMVTSNWTTCLYNGMYFSPEREFLHNSIVFSQRHIEGKVNMVAYKGSAFAVGRSSETSNLYSETESSMDTLEGFSPVDTSGFIAIQAIRLEKYGARKIRDGEPLAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5L7</accession>
    <name>Q2H5L7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_06048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222143.1">
        <property type="nucleotide sequence ID" value="XM_001222142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5L7"/>
    <dbReference type="GeneID" id="4390285"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06048"/>
    <dbReference type="HOGENOM" id="CLU_1234858_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5L7"/>
    <dbReference type="OrthoDB" id="10358386at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="224" mass="24881" checksum="7D09F97F18C5E8D5" modified="2006-03-21" version="1">MGIDRDTRPADKKFHKFRRDDQLRRYLTSRQQSHIARVINGHPGGGRPRLRAILPTVGLIWPFKAFMVGDSDEKVTTALRKITPHLSEERVENCFSQMFLEATKEISRPTHPPNGKVDFIVFIRILQGINMSSAGPKVSASQIREYEGRYPVDVVMPECPVAQAGPPRVPTGRVNRDNDVDMMADGIRDLAIEQSYKEGTGGGGSADGDVICGGMADRDVITYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5V5</accession>
    <name>Q2H5V5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rax2-like second domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222055.1">
        <property type="nucleotide sequence ID" value="XM_001222054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5V5"/>
    <dbReference type="STRING" id="306901.Q2H5V5"/>
    <dbReference type="GeneID" id="4390805"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05960"/>
    <dbReference type="eggNOG" id="ENOG502QQZD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_621120_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5V5"/>
    <dbReference type="OMA" id="ATIRTMC"/>
    <dbReference type="OrthoDB" id="2503993at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902929">
        <property type="term" value="C:plasma membrane of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048266">
        <property type="entry name" value="Rax2-like_second"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778:SF2">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20842">
        <property type="entry name" value="Rax2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rax2-like second" evidence="1">
        <location>
            <begin position="291"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="441" mass="47292" checksum="1AD6EB49C8A3CBDC" modified="2006-03-21" version="1">MARRPQWTDRDPVIIGCCTSNTNIEPSRPALGFQVESTPLNLRCHLLADLDRDAMRLPFGRRHAARSDFISSIPLILSLSSFAASPAAAISFTPVPAPNLDLSQLGRVVLAGDFSGISLYQFEEQNQRPPRNNGSEQLLARMPNGLFAPIVNTDATIRTMCTFNTDNGTVVVLGGNFTSIRDPDSDSKAMQSTAIALFDPDTAVVTPLPGLSGQVNALLCDQDKNTVYLGGSFVGANSTNALAWEGGRDWVNLPFAGFNGPVTSIAKAPNGNILFGGSFTGLGNASTPSTPDGQIINLSTASITSGSSSTTPGFSDPKNVVCQTSGEDGAGSTWLLQDNAPGFWDAKFRHGFQPTKLRLYNTHQDGRGTKTWRFTAMPINGIMNFTYIDPVTRQNASCTSECPLSDDKSIKFQDFHFVNVIGMKRSSAIDISAFYGSERGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5W4</accession>
    <name>Q2H5W4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein DSF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222046.1">
        <property type="nucleotide sequence ID" value="XM_001222045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5W4"/>
    <dbReference type="STRING" id="306901.Q2H5W4"/>
    <dbReference type="GeneID" id="4390832"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05951"/>
    <dbReference type="eggNOG" id="ENOG502R38G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033724_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5W4"/>
    <dbReference type="OMA" id="WGIKKDP"/>
    <dbReference type="OrthoDB" id="2148946at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="46939" checksum="0AB2C8FAC6B91D1A" modified="2006-03-21" version="1">MGLRDKFRKKHEEDEASANPTDATNPASPEFTFIRTDTHNAEIIYPPSAGPQREPGQFLSAEPKSDPSKQRRSLDVFRGSRSRSGSTASSQGSRRLSQRLHLSRSPSSSENVPQDLPEIVMPEGGVDDKDGTESQWEKRATILARENEKHRSRPGTPVHGSAPPVIPQLRLGDGPSGDSSGSQSKAVSSKELDEDIQEAIRLHEAGELEQSTALFGRLADPKGANNPLSQVLYGLALRHGWGCSQDSAKAVTFLSAAASNAADVEQLALQAGLKKGGAAKGELVLAIFELANCFRHGWGIPKDPIAAKQVGFLLLVKEGWICTVKGVAEFITDQDWQYYETAANLGDTDAMNEVAWCYFEGFGTKKDKVSLPSSPTQPSRSKKTRREPPRSPPAEHHPLSLSARSRTSRSALLYPERWAPTGLFPRNESQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H623</accession>
    <name>Q2H623_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221987.1">
        <property type="nucleotide sequence ID" value="XM_001221986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H623"/>
    <dbReference type="GeneID" id="4390219"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05892"/>
    <dbReference type="HOGENOM" id="CLU_1320760_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H623"/>
    <dbReference type="OrthoDB" id="10552265at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="208" mass="21880" checksum="6A4D0DC69D21E396" modified="2006-03-21" version="1">MSGGKVGRVEGVGWLGGRCDLEKRGRDWGGWRQAAMPRSVDGPARFSKQPASGAEWKAGAGARVGGARGPKGVCGIGWHGVELMGPPSLPQKMGPLQPHGVFRALGSRRKRQELKSQSQGGHQGVQGPGMTLHEQEEVATRRGLAFHLPAVCGGCSDMMVASVGALGCPGLGPYLGLNHPFLSSAVFRPVLVSYRLSRVDPCALHSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6B8</accession>
    <name>Q2H6B8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_05797</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221892.1">
        <property type="nucleotide sequence ID" value="XM_001221891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6B8"/>
    <dbReference type="STRING" id="306901.Q2H6B8"/>
    <dbReference type="GeneID" id="4390926"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05797"/>
    <dbReference type="eggNOG" id="ENOG502QXAC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021696_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6B8"/>
    <dbReference type="OMA" id="CERCVWE"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF273">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN SAMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="233"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ89178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="571" mass="64334" checksum="2CFA7C58D055F45D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7T4</accession>
    <name>Q2H7T4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_05281</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221376.1">
        <property type="nucleotide sequence ID" value="XM_001221375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7T4"/>
    <dbReference type="STRING" id="306901.Q2H7T4"/>
    <dbReference type="GeneID" id="4391364"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05281"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022195_0_2_1"/>
    <dbReference type="InParanoid" id="Q2H7T4"/>
    <dbReference type="OMA" id="EEYACAR"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF6">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AN1598-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ88662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="63430" checksum="4F2D2D82CBDE5256" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8M3</accession>
    <name>Q2H8M3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pathogen-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_03431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229947.1">
        <property type="nucleotide sequence ID" value="XM_001229946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8M3"/>
    <dbReference type="GeneID" id="4389656"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03431"/>
    <dbReference type="eggNOG" id="ENOG502QUA2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066755_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8M3"/>
    <dbReference type="OMA" id="KAFKRMM"/>
    <dbReference type="OrthoDB" id="65445at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053218">
        <property type="entry name" value="Pathogen-related_defense"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31723:SF10">
        <property type="entry name" value="PATHOGEN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31723">
        <property type="entry name" value="PATHOGENESIS-RELATED FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ91496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27204" checksum="81878FA2DF35A3A3" modified="2006-03-21" version="1">MATAETQNPPAEAPAPALPDYVLDEDAVLKDTNVNWRHGRAPDYSKTRKIFAETKQSNHQAGSLPDLVEKLVKNWEIEASYKVDLADWRTIDQSSYTFSVNGGPPQTGEHMLTVGTYNAIIEGNEYYCPMRSSFDASHKTFKRMMPTFAWEVLEVYAGPPKVAFKWRHWGTMKEDYTGLNNKGEKVTIKAHGGPIDIEGVVVAEVNDKLQLRSIEVFFDPMLMFRQMAPDGETGVTKVKADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8R4</accession>
    <name>Q2H8R4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sidoreflexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_03390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sideroflexin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229906.1">
        <property type="nucleotide sequence ID" value="XM_001229905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8R4"/>
    <dbReference type="FunCoup" id="Q2H8R4">
        <property type="interactions" value="249"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H8R4"/>
    <dbReference type="GeneID" id="4388800"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03390"/>
    <dbReference type="eggNOG" id="KOG3767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039425_0_0_1"/>
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    <dbReference type="OMA" id="GRVRHCA"/>
    <dbReference type="OrthoDB" id="6608471at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071454">
        <property type="term" value="P:cellular response to anoxia"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140300">
        <property type="term" value="P:serine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF6">
        <property type="entry name" value="SIDEROFLEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="203"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ91455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="35750" checksum="76306ACB7128163D" modified="2006-03-21" version="1">MSASLPGSRALPESHTLLVGSAGLEQAKNALIAYKQGHVNSMTPELWRAKKIVDSTLHPDTGEAVFLPFRMSCFVLSNLVVTAGMLTPGLGNRGTIAWQVANQSLNVAINYSNSNKSSPLSWSKIAQSYFLAVTASCSVAVGLNSLVPRLKSLSPSTRLILTRLVPFAAVASAGALNVFLMRGEEMRTGIDVFPATAKTKTKAETAVETSPAAALEKAPQADDDSSSSGGEKSLGKSKKAATLAVAETAASRVFNSSPIMVLPPLLLVRLQRGAWLRKNPRWTTPVNLGLILITSYAALPLALAAFPQRQRIKAESLEEEFHGRGGEGGLVEFNRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8W2</accession>
    <name>Q2H8W2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_03342</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpF family.</text>
    </comment>
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        <property type="protein sequence ID" value="EAQ91407.1"/>
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        <property type="nucleotide sequence ID" value="XM_001229857.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:isomerase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:carbohydrate metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF453 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00360)"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ91407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="659" mass="71420" checksum="945210EB009538BB" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H962</accession>
    <name>Q2H962_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229758.1">
        <property type="nucleotide sequence ID" value="XM_001229757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H962"/>
    <dbReference type="STRING" id="306901.Q2H962"/>
    <dbReference type="GeneID" id="4388617"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03242"/>
    <dbReference type="eggNOG" id="ENOG502S4NJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5369511at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="388" mass="42192" checksum="46FFDAECA72FFEC9" modified="2006-03-21" version="1">MADFAYRPTAPMTNERWLASRSAKFETGSTPSLPQSVTYTPGAAASTHNLPANFPAGVVSQLRRTPVEPTFSPIPACNPRLAQGPYTSPAPGPVSFKSSFGWDQPPSYPVNNPAPYQSRYSPSDSMDDLASPSLSDYSLDNAMLGSAAPGGGKTNGRMNGTVGGSGSGGSGGSGGGGGGGGGVSNGGVGTKPRTLRRPSNRDEFDGPHQYLKRPPAEYVAMQERELPRLPTHLLVQEQDSVLNQVNDRLSQCAYDFVAKYQFPIPLTQDMRPVERPQDREWTEWVYLLKRLATKRRIPARVLYNGQIKQFVTILENSLEMRHAAKHQSRPLKDDRNILQLISAGIQVAKIVKDAPAMDYLDRLYVSTEQRIQERVAAAAAASGTMRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9L7</accession>
    <name>Q2H9L7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA biogenesis protein RRP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ribosomal RNA-processing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_03087</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biogenesis of rRNA. Required for the formation of 18S and 5.8S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229603.1">
        <property type="nucleotide sequence ID" value="XM_001229602.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2H9L7">
        <property type="interactions" value="979"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H9L7"/>
    <dbReference type="GeneID" id="4389126"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03087"/>
    <dbReference type="eggNOG" id="KOG1070">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000845_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9L7"/>
    <dbReference type="OMA" id="GQYLRAY"/>
    <dbReference type="OrthoDB" id="412781at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00164">
        <property type="entry name" value="S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05702">
        <property type="entry name" value="S1_Rrp5_repeat_hs11_sc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05703">
        <property type="entry name" value="S1_Rrp5_repeat_hs12_sc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05693">
        <property type="entry name" value="S1_Rrp5_repeat_hs1_sc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05697">
        <property type="entry name" value="S1_Rrp5_repeat_hs5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04461">
        <property type="entry name" value="S1_Rrp5_repeat_hs8_sc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05708">
        <property type="entry name" value="S1_Rrp5_repeat_sc12"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="rRNA biogenesis protein RRP5"/>
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        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
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        <property type="entry name" value="rRNA biogenesis protein RRP5"/>
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        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
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        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
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        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
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    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
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        <location>
            <begin position="145"/>
            <end position="243"/>
        </location>
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    <feature type="domain" description="S1 motif" evidence="11">
        <location>
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    <feature type="domain" description="S1 motif" evidence="11">
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    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="542"/>
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    <feature type="domain" description="S1 motif" evidence="11">
        <location>
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    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="790"/>
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    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="893"/>
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    <feature type="domain" description="S1 motif" evidence="11">
        <location>
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            <begin position="1088"/>
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        <location>
            <begin position="1182"/>
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        <location>
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        <location>
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            <begin position="32"/>
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        <location>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00076674"/>
        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ91152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1766" mass="192673" checksum="1D2B23268435ABD2" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAD2</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CHGG_02822</name>
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    <organism evidence="2 3">
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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    <dbReference type="OrthoDB" id="20473at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="ZZZ3"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR22705:SF0">
        <property type="entry name" value="ZZ-TYPE ZINC FINGER-CONTAINING PROTEIN 3"/>
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    </dbReference>
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    </feature>
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        </location>
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        <location>
            <begin position="24"/>
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        </location>
    </feature>
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        <location>
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        </location>
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        </location>
    </feature>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ90887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="356" mass="36570" checksum="E318E53F5074DC55" modified="2006-03-21" version="1">MPGITITTKLPPRTAEAGTTPPCQASASSRQQSPSRPHVSPITPTQESTEFMGSRPAHPAPTTAQSTLPDFAAGRPVFTHTTQTDQVGMTPPPAQPIDFESNPDVLALKSAISILQLQRARATADVQLLSRAKDAALANPEAFTADLVSGRVRMEGDPLTSGRMRSANGGPAENDSESESDSDADSHPADQNGDGTRQQVTPESEFKTDSRTTPTSPTTTTTTTTNGAEGSNQRSHHPSSSSASSLAPGTASAPAWQTLPKPQTVVRCPPINWAQYGVVGESLDKLHAEQVAAPTPGAPMALGQGGAYAFKAGAAAAGGGGGGGGGGEPARRLNGVAAPYNPMKDKVEKKGRGGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAQ5</accession>
    <name>Q2HAQ5_CHAGB</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">CHGG_02699</name>
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001229214.1"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1151677_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HAQ5"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ90764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="241" mass="26024" checksum="F83DD982841F1B51" modified="2006-03-21" version="1">MEIHYNLLPCAVPALRHSGPWGRREGEGSPMPNLRQRDSILLSVLLREAPGLVMASSGNSSDDASGPSRAQAVHLPPLLQQLSSGLSELAISPSPPATEAATYDKDLAASEPVTDEEFPDDIIPGTVAEWQKLRCKNRRAVNRGQIIKNIQVETLYQWSSKGGGGGALRLAAALRDPRIKDALEPTGIKITDSEEAGDVFHSATVRREMKVLLTTDPFNDFKPYAHQGDDAATITEMCSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBH3</accession>
    <name>Q2HBH3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228947.1">
        <property type="nucleotide sequence ID" value="XM_001228946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBH3"/>
    <dbReference type="GeneID" id="4389227"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02431"/>
    <dbReference type="HOGENOM" id="CLU_1348775_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HBH3"/>
    <dbReference type="OrthoDB" id="10310761at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="203" mass="22134" checksum="C5CA88F907ED124B" modified="2006-03-21" version="1">MHNCCKLGQCFLFSVSRLSPGANIRWERGQPVGEKASANFTQSLRDEAGVAAEAPSKFVAQMVRRKPRRGAVKRRQEKGRFLQPHLWACIHVPGIPLAASRNPCKAWVSRAANSRCIRLSAIAKIGGADRCRAQGEGSGSGQWLFTQPQGCSRQVDSAEAAHWQAERRHLSQTTISSTVLDDRDTVVRSDSPPVSQGSALLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBK9</accession>
    <name>Q2HBK9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine--tRNA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_02395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228911.1">
        <property type="nucleotide sequence ID" value="XM_001228910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBK9"/>
    <dbReference type="STRING" id="306901.Q2HBK9"/>
    <dbReference type="GeneID" id="4389283"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02395"/>
    <dbReference type="eggNOG" id="KOG2298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166983_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HBK9"/>
    <dbReference type="OrthoDB" id="4740349at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ90460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="14081" checksum="BEA5B2C6A4A78700" modified="2006-03-21" version="1">MPVWCTDYPIRMVVKCKKFDRQLFESVLKRRFFFTEAFEIYRLSPNFKGDNRGLFDYATPGCALQTNIVDMWRKHFVLEENMLELDCTVITPELVLKTSGHVDKLTDWMCKDPIKGEHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBS8</accession>
    <name>Q2HBS8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_02326</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228842.1">
        <property type="nucleotide sequence ID" value="XM_001228841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBS8"/>
    <dbReference type="GeneID" id="4388442"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02326"/>
    <dbReference type="eggNOG" id="ENOG502RKFT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_460029_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HBS8"/>
    <dbReference type="OrthoDB" id="4580315at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="230"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="511"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="578"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ90391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="593" mass="65830" checksum="9C2097D158694C1A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HC16</accession>
    <name>Q2HC16_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_02238</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228754.1">
        <property type="nucleotide sequence ID" value="XM_001228753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HC16"/>
    <dbReference type="GeneID" id="4388976"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02238"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="InParanoid" id="Q2HC16"/>
    <dbReference type="OMA" id="AWEAQNT"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF73">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ90303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="52739" checksum="124D1DE2A5388EC7" modified="2006-03-21" version="1">MAEYQGDRSSSGGSYVSIFGISRDANLVGKQYSWLGSILYLAQLVMQPLAAFLLVKLPTGKVIGSAILLWGASLCIMSACTTFPSLLGLRFLLGSFEAMIAPSCVAVTQMWWRRSEQTLRTSYWNAMNGITAIVGSLFTYGLGHIESRVMFKYQIIFLFCGLLTVCYAGVVLVLMPDSPMEAKYLKEREKVIAVERLRANQMGVASREWRWDHVWETLWDLKTWCWFVAIVAISISSGGIGTFGSLIVRDFGYTNFDAILFNIPFGAIQFFMIIGSAWAATHWQRKGLTIAAVSVLPIVGTILMLTVPRSNHNKGVLLFGYYLDCQVSCLAAITPLIYAWQAQNTAGDTKKKCTSAMVFIGMCTGNVIGPLLYDESQAPLYRSGLIATLIMFALVGGVSALIPLYLMFLNRRHAKRREELGKSAALVDESMVSKKKMEDSKAVEAGESGRHLTALEEDNALQDMTDLQNEDFIYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HC73</accession>
    <name>Q2HC73_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_02181</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228697.1">
        <property type="nucleotide sequence ID" value="XM_001228696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HC73"/>
    <dbReference type="MEROPS" id="S53.007"/>
    <dbReference type="GeneID" id="4389548"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02181"/>
    <dbReference type="eggNOG" id="ENOG502QTN1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013783_4_0_1"/>
    <dbReference type="InParanoid" id="Q2HC73"/>
    <dbReference type="OMA" id="FELANCD"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF19">
        <property type="entry name" value="SERINE PROTEASE AORO, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S53" evidence="9">
        <location>
            <begin position="150"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="524"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="560"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="561"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="579"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="581"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ90246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="587" mass="64776" checksum="3449CC5C977AC2CF" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCD5</accession>
    <name>Q2HCD5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CHGG_02119</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21. Interacts with preproteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221340.1">
        <property type="nucleotide sequence ID" value="XM_001221339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCD5"/>
    <dbReference type="FunCoup" id="Q2HCD5">
        <property type="interactions" value="384"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HCD5"/>
    <dbReference type="GeneID" id="4386360"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02119"/>
    <dbReference type="eggNOG" id="KOG2832">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023309_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCD5"/>
    <dbReference type="OMA" id="NLRQPYT"/>
    <dbReference type="OrthoDB" id="287041at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000019">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10 15" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="18">
        <location>
            <begin position="237"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="527"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAQ93884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="537" mass="60412" checksum="8D2E33A1CFE0D08B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCX4</accession>
    <name>Q2HCX4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221151.1">
        <property type="nucleotide sequence ID" value="XM_001221150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCX4"/>
    <dbReference type="GeneID" id="4386480"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01930"/>
    <dbReference type="HOGENOM" id="CLU_3124902_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCX4"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="50" mass="5462" checksum="B43F7528CB3A898F" modified="2006-03-21" version="1">MAAPGMERTGMARTANSLFESEERFAGLVHQRAPNNNSLAGCTTERYTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HD22</accession>
    <name>Q2HD22_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_01882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221103.1">
        <property type="nucleotide sequence ID" value="XM_001221102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HD22"/>
    <dbReference type="GeneID" id="4387977"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01882"/>
    <dbReference type="HOGENOM" id="CLU_2399461_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HD22"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ93647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="93" mass="10136" checksum="9AABE470FB2456BE" modified="2006-03-21" version="1">MPAKSARECLDGNDASMVRLGIHRCGLGGVDPHACLEAGLWLVKKPSCPFLLLLARQRSSKRQATGLELPLLGSDLEPEHFLNVTLSCLSRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDD8</accession>
    <name>Q2HDD8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220987.1">
        <property type="nucleotide sequence ID" value="XM_001220986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDD8"/>
    <dbReference type="GeneID" id="4386749"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01766"/>
    <dbReference type="HOGENOM" id="CLU_2468854_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HDD8"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="88" mass="9458" checksum="9C527D248C49A911" modified="2006-03-21" version="1">MPTAMETVGLVVGVLVVAVSVAGIADSRLRQREELARAERRVREARASEATASSEARRAAREARRDVAAAQKRETTAVAVANEKVEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDK6</accession>
    <name>Q2HDK6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220919.1">
        <property type="nucleotide sequence ID" value="XM_001220918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDK6"/>
    <dbReference type="GeneID" id="4387328"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01698"/>
    <dbReference type="HOGENOM" id="CLU_2960562_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HDK6"/>
    <dbReference type="OrthoDB" id="370932at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1050.10">
        <property type="entry name" value="At2g23090-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026939">
        <property type="entry name" value="ZNF706/At2g23090_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118359">
        <property type="entry name" value="Expressed protein At2g23090/F21P24.15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="59" mass="6472" checksum="0FCB8A1FFEB1CD60" modified="2006-03-21" version="1">MGGGNGAKAAQKRARNDKKAGTKAVSQLKSVSSPWYPKYDASTTEEDLTRTFLNRTLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HED0</accession>
    <name>Q2HED0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220645.1">
        <property type="nucleotide sequence ID" value="XM_001220644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HED0"/>
    <dbReference type="GeneID" id="4387717"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01424"/>
    <dbReference type="HOGENOM" id="CLU_915269_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HED0"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="304" mass="32031" checksum="94565A7869AD5185" modified="2006-03-21" version="1">MGCPLGICNDGCAHARREQTGGGHGGGFDSARQRTQVPSSPAAQPGPGSFAPVPPSAIHRTSSEQWGGGLWEWRRCKAPVKNLVGAGAGNVAMGHLLKAQAVNGSLICEFRCAGTPLTTKDPKSSRNEPLACGRVEFDSDNGSGISKQDALPSRLSVHSTAVNVARDGHHLGLYRGILSGLLTASSDKSSKSTPRVNDRSAPAALKIFDPGVPWAGLQAWTMNPTAMLPKPADPYNHPRTSATVAQARGFLCATPTWVPGYFVPPENRGVGGEEQFSTSIHACHDPDSLFPVRILSMENRGPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEM9</accession>
    <name>Q2HEM9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_01325</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220546.1">
        <property type="nucleotide sequence ID" value="XM_001220545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEM9"/>
    <dbReference type="STRING" id="306901.Q2HEM9"/>
    <dbReference type="GeneID" id="4387244"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01325"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_743939_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HEM9"/>
    <dbReference type="OrthoDB" id="5228166at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ93090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="41553" checksum="51359F1E546AE9CA" modified="2006-03-21" version="1">MGEPIIGSAYWLGARRDESSHPKICQLTMEFVQATQPNTGKFWGPYADTSKDEEIYHTPIQSMSRALRTHGSVVGFKRNGNMLGITWIRHLHGGSFFRDIDGTMRAFSTRRMNHIVPEIWPLFEKAAEGLVANAGADAVDIQPHLQQAMAEGTIKIFLSEKYNRADFKERMIKVATDIAYLTGLDPNRSFLARKFPLLWHAAKVYATYSGINGLIRIVSMIWVTFFLAQHPDSQESIRKEATSIIETGGAFKLEGLQNAVLTDSFIREALRTKGDSVNAVRQCVQDVELDGFTIPKGSLVFPFTYQCYRNSNLMENANEFIGDRWVSTGKSATTTGLEYPAFGLGRWACPGRFLAINACAPDGKLVVRRVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HET1</accession>
    <name>Q2HET1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonine/serine exporter-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_01273</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220494.1">
        <property type="nucleotide sequence ID" value="XM_001220493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HET1"/>
    <dbReference type="FunCoup" id="Q2HET1">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="GeneID" id="4386534"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01273"/>
    <dbReference type="eggNOG" id="ENOG502QPMM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007078_2_1_1"/>
    <dbReference type="InParanoid" id="Q2HET1"/>
    <dbReference type="OMA" id="KKRVGWH"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="517"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="607"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="656"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="808"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="879"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="4">
        <location>
            <begin position="385"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="776"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ93038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="914" mass="99172" checksum="A94CFF3732CF4D94" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HF58</accession>
    <name>Q2HF58_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA polymerase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_01146</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYBBP1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220367.1">
        <property type="nucleotide sequence ID" value="XM_001220366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HF58"/>
    <dbReference type="FunCoup" id="Q2HF58">
        <property type="interactions" value="310"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HF58"/>
    <dbReference type="GeneID" id="4388145"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01146"/>
    <dbReference type="eggNOG" id="KOG1926">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005212_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HF58"/>
    <dbReference type="OMA" id="VWKHDDP"/>
    <dbReference type="OrthoDB" id="342531at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007015">
        <property type="entry name" value="DNA_pol_V/MYBBP1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213:SF2">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04931">
        <property type="entry name" value="DNA_pol_phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="705"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="791"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="713"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="748"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="791"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ92911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1016" mass="111584" checksum="7E202815AE7BD4E2" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-07-27" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HF90</accession>
    <name>DAPB_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Probable dipeptidyl-aminopeptidase B</fullName>
            <shortName>DPAP B</shortName>
            <ecNumber>3.4.14.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DAPB</name>
        <name type="ORF">CHGG_01114</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.</text>
            <dbReference type="EC" id="3.4.14.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Lysosome-like vacuoles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S9B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.5"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220335.1">
        <property type="nucleotide sequence ID" value="XM_001220334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HF90"/>
    <dbReference type="SMR" id="Q2HF90"/>
    <dbReference type="FunCoup" id="Q2HF90">
        <property type="interactions" value="274"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HF90"/>
    <dbReference type="ESTHER" id="chagb-q2hf90">
        <property type="family name" value="DPP4N_Peptidase_S9"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q2HF90">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="GeneID" id="4388188"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01114"/>
    <dbReference type="eggNOG" id="KOG2100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006105_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HF90"/>
    <dbReference type="OMA" id="MRTPQEN"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF200">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 10, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0031">Aminopeptidase</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0720">Serine protease</keyword>
    <keyword id="KW-0735">Signal-anchor</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="chain" id="PRO_0000412141" description="Probable dipeptidyl-aminopeptidase B">
        <location>
            <begin position="1"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Signal-anchor for type II membrane protein" evidence="2">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="topological domain" description="Vacuolar" evidence="2">
        <location>
            <begin position="132"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="773"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="850"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="883"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="925" mass="102583" checksum="A6C59C5AB4BE82DF" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFJ4</accession>
    <name>Q2HFJ4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_01010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220231.1">
        <property type="nucleotide sequence ID" value="XM_001220230.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4388047"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01010"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001836_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HFJ4"/>
    <dbReference type="OMA" id="WSRTPMH"/>
    <dbReference type="OrthoDB" id="4589604at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF676" evidence="6">
        <location>
            <begin position="52"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="953"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1083"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1125"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1193"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1370"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1407"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1537"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1577"/>
            <end position="1591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ92775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1602" mass="176566" checksum="58CC93B1C966CDAE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGF2</accession>
    <name>Q2HGF2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coatomer subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_00702</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the COPE family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219923.1">
        <property type="nucleotide sequence ID" value="XM_001219922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGF2"/>
    <dbReference type="FunCoup" id="Q2HGF2">
        <property type="interactions" value="175"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HGF2"/>
    <dbReference type="GeneID" id="4386681"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00702"/>
    <dbReference type="eggNOG" id="KOG3081">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049363_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HGF2"/>
    <dbReference type="OMA" id="MIVLSQH"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000613">
        <property type="entry name" value="Coatomer subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016478">
        <property type="entry name" value="Coatomer_esu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ92467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="294" mass="31122" checksum="6CA3601D0BA00D9F" modified="2006-03-21" version="1">MDPYSAEGELINIHNHFHQGQYQEVITFDTSTLSPENALPARVLQLRARVALGEAAEALADVKGAAEPELQAVGALAQFALGKVDAAVAAAERLAAESAENTTVQVLGGTVLQAAGKSEEALALLGQHQGSLDAVALIVQIHLNNNRNDLAVKEVAAARRWAQDSLLVNLAESWVGLRLGGEKYQQAFYVFEELAQAPATSSVRTLVSQAVAELHLGRTEEAQAALDQALTKEPEHAEAIANLLVLSVITGKSAEEAISSLQKANAEHPLLVDLAEKSELFDKAATKYKAKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGH4</accession>
    <name>Q2HGH4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Autophagy-related protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_00680</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATG7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219901.1">
        <property type="nucleotide sequence ID" value="XM_001219900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGH4"/>
    <dbReference type="FunCoup" id="Q2HGH4">
        <property type="interactions" value="668"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HGH4"/>
    <dbReference type="GeneID" id="4386836"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00680"/>
    <dbReference type="eggNOG" id="KOG2337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012998_2_1_1"/>
    <dbReference type="InParanoid" id="Q2HGH4"/>
    <dbReference type="OMA" id="WSFYYWF"/>
    <dbReference type="OrthoDB" id="338614at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01486">
        <property type="entry name" value="Apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000243">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006285">
        <property type="entry name" value="Atg7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019034">
        <property type="entry name" value="UPF0390"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01381">
        <property type="entry name" value="E1_like_apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09495">
        <property type="entry name" value="DUF2462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="10">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="10">
        <location>
            <begin position="72"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="9">
        <location>
            <begin position="239"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="613"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="628"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="677"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606285-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ92445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="696" mass="76348" checksum="1843257FA1589D7D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGV8</accession>
    <name>Q2HGV8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PXA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_00546</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219767.1">
        <property type="nucleotide sequence ID" value="XM_001219766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGV8"/>
    <dbReference type="STRING" id="306901.Q2HGV8"/>
    <dbReference type="GeneID" id="4387899"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00546"/>
    <dbReference type="eggNOG" id="ENOG502RM76">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007315_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGV8"/>
    <dbReference type="OMA" id="INGWIIH"/>
    <dbReference type="OrthoDB" id="41200at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000065">
        <property type="entry name" value="PX domain protein (AFU_orthologue AFUA_2G07450)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF47">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 122 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="4">
        <location>
            <begin position="137"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="438"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="732"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="482"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="799"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ92311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1042" mass="113365" checksum="122E0CA439D7D8F3" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH58</accession>
    <name>Q2HH58_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1917 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0696 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219667.1">
        <property type="nucleotide sequence ID" value="XM_001219666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH58"/>
    <dbReference type="GeneID" id="4388232"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00446"/>
    <dbReference type="eggNOG" id="ENOG502SG47">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1058038_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HH58"/>
    <dbReference type="OMA" id="RPIYYKC"/>
    <dbReference type="OrthoDB" id="10067381at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015034">
        <property type="entry name" value="Bles03"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977:SF1">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08939">
        <property type="entry name" value="Bles03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32535" checksum="B01E238EA336A39A" modified="2006-03-21" version="1">MDPDSDFYGDEGTTSAFKARVDQFDVVEWWDSRNVVTRHLQHAAHKQPAPTLRNGRLHNLYEGLPGAWQLSEPIECFLFRLPPSTTDLRPGLDWIYVANPYAPPGPGQAHAQFCRGGEERLALFAEFEQMATASIAKTSGSALTALKKEVANERRELVEDLRDLASACNIVTGKWMLFPEPERVDEIWAKVAMATVNGELGIAAKVATRVEAEKARLVCVYTSDFRDKDDVARVLNRMRELELVRPSGKQIYYKSAYDLDRSDSISWQIPTRPLTGTPKATKALAMVHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH86</accession>
    <name>Q2HH86_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_00418</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WHI5/NRM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219639.1">
        <property type="nucleotide sequence ID" value="XM_001219638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH86"/>
    <dbReference type="STRING" id="306901.Q2HH86"/>
    <dbReference type="GeneID" id="4387099"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00418"/>
    <dbReference type="eggNOG" id="ENOG502RZ4H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025591_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HH86"/>
    <dbReference type="OMA" id="HSRCETP"/>
    <dbReference type="OrthoDB" id="2163387at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013734">
        <property type="entry name" value="TF_Nrm1/Whi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468:SF1">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468">
        <property type="entry name" value="YALI0A15257P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08528">
        <property type="entry name" value="Whi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="120"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="208"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ92183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="342" mass="37987" checksum="5CB260E56E5081F8" modified="2006-03-21" version="1">MMSSPLKKQPEAVADRVLKRAEISKMARRLQNRLALAQFKTKHNLVNETLDMIEPKFEQEMRRRRLQDGDILSDSSSSASDLPYPSRTLMSSPLKAPLFSDAIGSSNGSTGHRKRTYLASFDDNGYSSPSKRFRQSPTAHRSFSSHHPFTQSSPIKPRRQQHFTTSTGPDISFYSGSRQISDVLTTTNYAAHSDDEDDLPTHSFHVNHVRVSPPRTPPMRSRTLMKKPKDRQPTANESKSGEEGADLLLYLAASPSPANPPRNRMEPPSTPPPKNKLALPSSMMTTPGGGNPYPATPGLGFDFAEFLHMTPSPAQKPWKTPLAGKTPRSVARRRLTFDDIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHI2</accession>
    <name>Q2HHI2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219543.1">
        <property type="nucleotide sequence ID" value="XM_001219542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHI2"/>
    <dbReference type="GeneID" id="4388209"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00322"/>
    <dbReference type="eggNOG" id="ENOG502SIR2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028280_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHI2"/>
    <dbReference type="OMA" id="WIEINNA"/>
    <dbReference type="OrthoDB" id="68575at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF26">
        <property type="entry name" value="FMN REDUCTASE LOT6, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209180" description="Amine oxidase domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="53967" checksum="9AA3FB9FD6BC0B0C" modified="2006-03-21" version="1">MARIVLTFVCLLWALVPISFATEGEGEDKGKGKGGGGPVTTIHRDVAIVGGGAAGSYSAVRLREDFGVSVVVIEKDNKLGGHVNTWVDPATGRGFDAGVQNWIEINNASSFFERFGVAVQPNVRSVLDQHFIDFATGARLTNYTPPPTADRSAALKRYLAAAERFLPILEPGWWNFPQPSEIPSDLLLPFRDFAAKYNLTAALPQIFATTGFGKHNFMDSLTLFFMRSFDVSMARTLLGLEANFVPVSRRNQDLYDAILTFLGPDALTRSTVTDAKRWDGKRGVTLEVYNWATGATTRVIAKKLLFTVAPTEENLEPFNPNGDEKEAFSGLYYSSSVVGIVSHPSLPLQASLVNTPEAAQPANWAAAAPSSPFNTRFENYPNSTYYRVIAVGDQKFNKEQARDVIQSAFDRMVAAGTLQQTTPLQNLTFHLLEPHGPVSASASRLAVDTGIIQKLNGLQGKRSIWYTGAAWSVHLTTSLWRFTDTVLPKVVASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHI9</accession>
    <name>Q2HHI9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_00315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219536.1">
        <property type="nucleotide sequence ID" value="XM_001219535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHI9"/>
    <dbReference type="GeneID" id="4386998"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00315"/>
    <dbReference type="HOGENOM" id="CLU_2385942_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHI9"/>
    <dbReference type="OrthoDB" id="10535568at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ92080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="94" mass="10546" checksum="B0B39C99D91F58BE" modified="2006-03-21" version="1">MDPYDGRRSPDFIFFGDEGKKPIITEYARGSKFHSGDKVYLLSEDGRFRTGGPYYIGDMGSNSSLTMYTLISEDGGKVLDGAEVKEERLEEYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHU3</accession>
    <name>Q2HHU3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219432.1">
        <property type="nucleotide sequence ID" value="XM_001219431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHU3"/>
    <dbReference type="GeneID" id="4387505"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00211"/>
    <dbReference type="HOGENOM" id="CLU_1447507_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHU3"/>
    <dbReference type="OrthoDB" id="4842715at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="187" mass="20282" checksum="066809B70A04DC23" modified="2006-03-21" version="1">MAIGPPGGGGEEAEDPELCPVEDRGKDMGDGASQSARSVQKVHPVGAGLWRIIVSHPPRMWEAKPVKKGITKALEKAQNKSLRIVAGAFKSTPIRNLETETWIPPLDLYLNKRLADFENRLQRPDLDDGRGGKKTAASVVLTACRKIQQRLSSRRGNRGRPRTFGTSRAYGGGESRGHGHALDGGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM73</accession>
    <name>Q2GM73_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226198.1">
        <property type="nucleotide sequence ID" value="XM_001226197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GM73"/>
    <dbReference type="STRING" id="306901.Q2GM73"/>
    <dbReference type="GeneID" id="4397193"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10931"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061410_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GM73"/>
    <dbReference type="OMA" id="QCPACDP"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="34"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="268"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="381" mass="42901" checksum="A6DC4568D321D1AE" modified="2006-03-21" version="1">MTWLKAMLRLESTFRAQSRLAQSAVGQLESHFPLAFEIRSSPGKGLGVFATKNIPRDAVIMRDPLVFRAERGEELADLHHKFTMLPTATRQKILELSVGSGVHDFSAVIKELTAQQGGDEDCEKALIELFRLEDIIAENAFNAVPHNIDSASVLLYLNASRLNHSCIPNADPASKDDTSYMVMRANRDINAGEEITSSYILRVVPRATRLQQLSKGWGFTCQCPACDPKNPFSDSHERRLKALLQLYTESACYMNKEGRLKDAERSSYGALKQAADRAKRQIEMLSEHHSLRVFSRESCLGALDIAIAKYKLKRLESDLEEALKLLELIIEADKLYHGEITIGAHEELYKRLRRGDISSMWLLYLCTPLLFSSAEKRTLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMB6</accession>
    <name>Q2GMB6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226155.1">
        <property type="nucleotide sequence ID" value="XM_001226154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMB6"/>
    <dbReference type="GeneID" id="4397349"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10888"/>
    <dbReference type="eggNOG" id="ENOG502SYM4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021744_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GMB6"/>
    <dbReference type="OrthoDB" id="4564371at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ83070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="423" mass="48259" checksum="27949518461F2425" modified="2006-03-21" version="1">MLDEWRGTAAYLSSNIKPGALQLLLVCDFGQKEVEAAEQAVAPLPSPPRAQRTAMFDFCSSPEYPGCANSPGVQHYKPASPWKEVHVEQAGTSGYQYLCSGCSAWEGLSCPPSHHHGCQYGGCHRQANIQNGLVRYHHPSIGCFCRVRHAAFSSTCKCWAPPTPLFLICRHLCEDARYVFFSANRFVVSDSLASGNPWIAFDVLRTLNFESPEQQGNYWETEEYRQAQPPRAYPAHRFAASQFLREVVPADCLGYLRFLELVFPPYNHECWPHDGHPALQDWIDTLDWVEDKINTPAITLRLTMAGLRGWSPAYPDGREELTQAQGDAVLAGYDRILRPLARLGKHGLTRFYADFAWPWKWTNWVGERLLRDYAANRSWLREQEKSLNERAERLILGDQHDRLRSHEGEPEESPWKIHCEPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMC4</accession>
    <name>Q2GMC4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226147.1">
        <property type="nucleotide sequence ID" value="XM_001226146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMC4"/>
    <dbReference type="GeneID" id="4397186"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10880"/>
    <dbReference type="eggNOG" id="ENOG502RISZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_721602_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GMC4"/>
    <dbReference type="OrthoDB" id="5153349at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="383" mass="41180" checksum="8DCEAE42DA4AA18C" modified="2006-03-21" version="1">MASSVSAVYPIPPRPNKRDQGTIGSDLIVTYHSDLAQCDILPSGSRYTSAGNFKAGTFLPFIQPAFIQELYPRLLSVGSSGWETDEPQSVQVALALPRDDGLTPVIPRQLGGPDETTLWPTTSAHVSFAGPVDLDTFHIKDGVWPEPLIKTSVFVKLGSYLQPENDRPPRKGIHICHVLVLFPVDQQPWKSLAGWMRTAANPFPKGSWIACSGRVLGVLDRDLIRGPQLVDSSVRILVVLPDNWEFIRQNSLSTNNTPTSKSSNLVDKSPTTPRPAGPGGVASRNPFSSPSRAPKTAERKTTALAAGPKAAVASITADPAPTFTVPSSDGDDSNDGSDTEELLDAQLVSSSSTPTKKRKEPSSPEPARSKRSTAGRKKARLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMZ8</accession>
    <name>Q2GMZ8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228583.1">
        <property type="nucleotide sequence ID" value="XM_001228582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMZ8"/>
    <dbReference type="GeneID" id="4396188"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10656"/>
    <dbReference type="HOGENOM" id="CLU_000680_23_4_1"/>
    <dbReference type="InParanoid" id="Q2GMZ8"/>
    <dbReference type="OMA" id="HATEPYA"/>
    <dbReference type="OrthoDB" id="5059038at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31036" checksum="A16BF7C95A4CDD39" modified="2006-03-21" version="1">MVGIGGVVRLPLPMRDGSRNEAFSVTLGSRSEQNPFSGELAAIGNKAAVMALERPHQQSGQQYLCQAYDAISALRKAGNTISVVWIQAGTKNELLNTAKAKAKEATRQDATPQTHDPAMRSTALRIAWAKRAPPTSLPDKVGRHSKRVDIALPGKHTQLLYDHLSRSEAGVLAQLRTGMAKLNTYLHRIKAAPSDPVYVWTSSERQWTHFPPSDASNGINTRREMLQCTGCPLGGNLLPFYLGGKSRSDDKDWSPNMRAVRATIRFAIATGRLRTEQQQNEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN25</accession>
    <name>Q2GN25_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_10629</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228556.1">
        <property type="nucleotide sequence ID" value="XM_001228555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN25"/>
    <dbReference type="STRING" id="306901.Q2GN25"/>
    <dbReference type="GeneID" id="4396425"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10629"/>
    <dbReference type="eggNOG" id="KOG0615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038483_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GN25"/>
    <dbReference type="OMA" id="IRRMACF"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF23">
        <property type="entry name" value="CDC7 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="165"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="489"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ84225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="532" mass="58878" checksum="1C8889E2F8632C77" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNI5</accession>
    <name>Q2GNI5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_10469</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228396.1">
        <property type="nucleotide sequence ID" value="XM_001228395.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4396178"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10469"/>
    <dbReference type="eggNOG" id="KOG2029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001384_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GNI5"/>
    <dbReference type="OMA" id="CEWLINR"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="246"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="3">
        <location>
            <begin position="538"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1172"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1172"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1218"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1238"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1277"/>
            <end position="1289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ84065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1459" mass="162137" checksum="785165F8919AFEB7" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNW8</accession>
    <name>Q2GNW8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_10336</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228263.1">
        <property type="nucleotide sequence ID" value="XM_001228262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNW8"/>
    <dbReference type="STRING" id="306901.Q2GNW8"/>
    <dbReference type="GeneID" id="4396813"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10336"/>
    <dbReference type="eggNOG" id="ENOG502S9HG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109915_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNW8"/>
    <dbReference type="OrthoDB" id="2117453at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF5">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="12"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ83932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="163" mass="16731" checksum="2A4511392D86A380" modified="2006-03-21" version="1">MKLTSMSFPLMPLIRISQGVFALLVIILSGFVANWYTSTTPLPSPSQVTFLLFSEGLSPNPYITAPFDLTNALFHLAGFSAHAAFLNGLLFCRGDVCHAAQASVAFAAFSFAVWSASAALTVLEAVKVRRAGAGAGAGAAVGGGAGRPAGTGAMPWPGKKEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNX1</accession>
    <name>Q2GNX1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228260.1">
        <property type="nucleotide sequence ID" value="XM_001228259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNX1"/>
    <dbReference type="STRING" id="306901.Q2GNX1"/>
    <dbReference type="GeneID" id="4396810"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10333"/>
    <dbReference type="eggNOG" id="ENOG502S2RJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060150_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNX1"/>
    <dbReference type="OMA" id="RWNDQYK"/>
    <dbReference type="OrthoDB" id="2530521at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="327" mass="33002" checksum="206409C4912A6CFE" modified="2006-03-21" version="1">MADFEAPPGPPPPKVPEGWVARWNDQYKEWFYVNTYTKKSQWEKPTEPAQPPHDDLGAPPGYTPGATPAPSDTKVNPYDNPNQGAAASYLNSSSNTPGGSSFHGNEDEDARLARQLQAEEDARARASPSYQQQGQGQQSPFPGQLPPRPDDKSRSGGGLLGKIFGGGKKPMGGGGGGGHGLPGGLGGILGGGGSGHHGGGGYQQPYGGAPGGYGAPGGYGAPGGYGAPGGYGQPHGGGYYPPQQHGYPPQGGYYPPQQHGYGGQHGGYKKSGGSNMGMMAGGAALGVGAGLLGGALVADAIQDSNEDAYQDGFQDGADFDDGGGGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GP34</accession>
    <name>Q2GP34_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228197.1">
        <property type="nucleotide sequence ID" value="XM_001228196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GP34"/>
    <dbReference type="GeneID" id="4396289"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10270"/>
    <dbReference type="HOGENOM" id="CLU_3159924_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GP34"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ83866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="48" mass="5317" checksum="0FAB7B121AD9CF09" modified="2006-03-21" version="1">MAPNQMAVLGLVIRLFKARRRRDVGREAAVVAARYRLPMGFPIPGHAS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2026-01-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPT8</accession>
    <name>CCDA_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MFS-type transporter ccdA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cochliodone A biosynthesis cluster protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ccdA</name>
        <name type="ORF">CHGG_10016</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2025" name="J. Am. Chem. Soc." volume="147" first="11555" last="11563">
            <title>Mechanism of Unexpected In-Trans Post-PKS Polyketide Reduction in Cochliodone Biosynthesis.</title>
            <authorList>
                <person name="Sarmales-Murga C."/>
                <person name="Sato M."/>
                <person name="Kosaka M."/>
                <person name="Akaoka F."/>
                <person name="Watanabe K."/>
            </authorList>
            <dbReference type="PubMed" id="40111931"/>
            <dbReference type="DOI" id="10.1021/jacs.5c03717"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">MFS-type transporter; part of the gene cluster that mediates the biosynthesis of cochliodone A, a dimerized azaphilone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227943.1">
        <property type="nucleotide sequence ID" value="XM_001227942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPT8"/>
    <dbReference type="GeneID" id="4395927"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10016"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_6_1"/>
    <dbReference type="InParanoid" id="Q2GPT8"/>
    <dbReference type="OMA" id="RYACESY"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000462664" description="MFS-type transporter ccdA">
        <location>
            <begin position="1"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
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        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="40111931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="40111931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ83612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="526" mass="57524" checksum="54D83B492E68F4BE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPY4</accession>
    <name>Q2GPY4_CHAGB</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CHGG_09970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ83566.1"/>
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    </dbReference>
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    <dbReference type="GeneID" id="4396111"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09970"/>
    <dbReference type="HOGENOM" id="CLU_1959316_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPY4"/>
    <dbReference type="Proteomes" id="UP000001056">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="128" mass="13028" checksum="75127DAF0B72F8D2" modified="2006-03-21" version="1">MLTAPRESVLTPSIHADRPQWDGVDLATEDAADHANAEQPRKTINGLEMAVAASRGACGGRGRGASSRRGGATSSTPRGGARGSQRGGSQRRGAGSRGGRVAKPARARATGARQSGRLAAQVTEESLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPZ6</accession>
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            <fullName evidence="4">TRP C-terminal domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="5" type="ORF">CHGG_09958</name>
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    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="AlphaFoldDB" id="Q2GPZ6"/>
    <dbReference type="STRING" id="306901.Q2GPZ6"/>
    <dbReference type="GeneID" id="4396452"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09958"/>
    <dbReference type="eggNOG" id="ENOG502R2RV">
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    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF8">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_2G17475)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208874" description="TRP C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="32"/>
            <end position="769"/>
        </location>
    </feature>
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        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
    </feature>
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        <location>
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            <end position="407"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="TRP C-terminal" evidence="4">
        <location>
            <begin position="389"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="741"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="591"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="747"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ83554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="769" mass="82394" checksum="D8A4B58777241C93" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQ56</accession>
    <name>Q2GQ56_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_09898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227825.1">
        <property type="nucleotide sequence ID" value="XM_001227824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQ56"/>
    <dbReference type="GeneID" id="4396261"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09898"/>
    <dbReference type="eggNOG" id="ENOG502SNCM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1421272_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQ56"/>
    <dbReference type="OMA" id="PRWHADD"/>
    <dbReference type="OrthoDB" id="10261951at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ83494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="191" mass="21545" checksum="D057768FB1B4C43B" modified="2006-03-21" version="1">MKFLKSSKSPPLPTRDFHFIPIPNTPINPPPLTLTHTTTWTYCGPLLPLSNTTTNNPPTPPTTTSLSPTFHAWCAHTLTPTSAPHLLPRLTPLLHAIHAFLRQHHLHHYWLTLRASQPTPTFDTPRWHADDDFFDPARSDAARGRWKLCATLQGPGTLFAAEGGTARGVLRRAKENWEDGWRRRGRMFVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQA7</accession>
    <name>Q2GQA7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_09847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
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    </evidence>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
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                <person name="Untereiner W.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <keyword evidence="5" id="KW-0804">Transcription</keyword>
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            <end position="406"/>
        </location>
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    </feature>
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        </location>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="1190" mass="130083" checksum="93CB8045747504C4" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
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                <person name="Untereiner W.A."/>
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    </dbReference>
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        <property type="entry name" value="Putative ff domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045148">
        <property type="entry name" value="TCRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377">
        <property type="entry name" value="TRANSCRIPTION ELONGATION REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377:SF3">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="543"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="617"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="706"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1022"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="627"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="706"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="745"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="805"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1026"/>
            <end position="1088"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ85524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1106" mass="125748" checksum="C19DF09D9A60857B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRC8</accession>
    <name>Q2GRC8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_09476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227403.1">
        <property type="nucleotide sequence ID" value="XM_001227402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRC8"/>
    <dbReference type="ESTHER" id="chagb-q2grc8">
        <property type="family name" value="Fusarinine_C_esterase_sidJ"/>
    </dbReference>
    <dbReference type="GeneID" id="4395710"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09476"/>
    <dbReference type="eggNOG" id="KOG4840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049633_3_0_1"/>
    <dbReference type="InParanoid" id="Q2GRC8"/>
    <dbReference type="OrthoDB" id="10034502at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF1">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ85462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="277" mass="30514" checksum="C917200A68480F58" modified="2006-03-21" version="1">MGSKFWPKRRFAGHHCIILRKTLVAFEFTPNHKPQPNSILFLGGLGDGLATTSYVADIVTSLQPTQWSLFTLNLTSSYQSWGFGHLDRDTDEIAQCIAHIHAHKTAHFGSPGRLVLMGHSTGSQCVLHYLSQPNPHTRIPRFDRGLEHSHRPVVDGAIMQAPVSDREAIHLIMRDGFLGRSPAQLRETYDRLVALARAGVDGDGDGDGDEDGCDSMLPIHLTAQFGYPRNTPVSCRRFLSLVSPDSPGRPAEDDMFSSDLGEECLGRTFGMVGRRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRZ4</accession>
    <name>Q2GRZ4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_09260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227187.1">
        <property type="nucleotide sequence ID" value="XM_001227186.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2GRZ4">
        <property type="interactions" value="1084"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GRZ4"/>
    <dbReference type="GeneID" id="4395403"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09260"/>
    <dbReference type="eggNOG" id="KOG0168">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0170">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000366_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GRZ4"/>
    <dbReference type="OMA" id="AEPLSQF"/>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057948">
        <property type="entry name" value="TPR_TRIP12_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25579">
        <property type="entry name" value="TPR_TRIP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="1599"/>
            <end position="1955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="605"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="743"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1155"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1396"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="770"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="795"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="816"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="867"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1187"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1248"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1300"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ85246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1955" mass="213830" checksum="B99D71476F8C7429" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GS27</accession>
    <name>Q2GS27_CHAGB</name>
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            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">CHGG_09227</name>
    </gene>
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        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
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        <dbReference type="NCBI Taxonomy" id="306901"/>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227154.1">
        <property type="nucleotide sequence ID" value="XM_001227153.1"/>
    </dbReference>
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    <dbReference type="STRING" id="306901.Q2GS27"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09227"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_2_1"/>
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    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
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    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="4">
        <location>
            <begin position="44"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="340"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="835"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="868"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="901"/>
            <end position="933"/>
        </location>
    </feature>
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        <location>
            <begin position="934"/>
            <end position="966"/>
        </location>
    </feature>
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        <location>
            <begin position="967"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1000"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1033"/>
            <end position="1062"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ85213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1062" mass="117106" checksum="70EAA3A4905D1FA8" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GS57</accession>
    <name>Q2GS57_CHAGB</name>
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        <recommendedName>
            <fullName evidence="10">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_09197</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001227123.1"/>
    </dbReference>
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    <dbReference type="STRING" id="306901.Q2GS57"/>
    <dbReference type="GeneID" id="4394766"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09197"/>
    <dbReference type="eggNOG" id="KOG2744">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008152_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GS57"/>
    <dbReference type="OMA" id="DKYKFDS"/>
    <dbReference type="OrthoDB" id="338531at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.60:FF:000021">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit rsc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
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    </dbReference>
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        <property type="entry name" value="ARID_dom_sf"/>
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    <dbReference type="InterPro" id="IPR011989">
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    </dbReference>
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        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01388">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="15"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="RFX-type winged-helix" evidence="7">
        <location>
            <begin position="645"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="821"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="938"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
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        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="824"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="940"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ85183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1009" mass="111769" checksum="7AC11927E5158147" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSD9</accession>
    <name>Q2GSD9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_09115</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227042.1">
        <property type="nucleotide sequence ID" value="XM_001227041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSD9"/>
    <dbReference type="FunCoup" id="Q2GSD9">
        <property type="interactions" value="302"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GSD9"/>
    <dbReference type="GeneID" id="4394809"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09115"/>
    <dbReference type="eggNOG" id="KOG2517">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_2_3_1"/>
    <dbReference type="InParanoid" id="Q2GSD9"/>
    <dbReference type="OMA" id="FMLMNIG"/>
    <dbReference type="OrthoDB" id="5422795at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000086">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000756">
        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="11">
        <location>
            <begin position="100"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="12">
        <location>
            <begin position="334"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="28"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ85101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="593" mass="64496" checksum="02FE8351916CB457" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSP9</accession>
    <name>Q2GSP9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_09005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226932.1">
        <property type="nucleotide sequence ID" value="XM_001226931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSP9"/>
    <dbReference type="GeneID" id="4395442"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09005"/>
    <dbReference type="eggNOG" id="ENOG502RNYM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_442108_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSP9"/>
    <dbReference type="OrthoDB" id="4567294at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00306">
        <property type="entry name" value="Peptidases_S8_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051048">
        <property type="entry name" value="Peptidase_S8/S53_subtilisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399:SF4">
        <property type="entry name" value="CELL WALL-ASSOCIATED PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399">
        <property type="entry name" value="SUBTILISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="DUF7580" evidence="6">
        <location>
            <begin position="43"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="5">
        <location>
            <begin position="418"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="293"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="313"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ84991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="618" mass="67379" checksum="2D3E681D373E4A06" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSY7</accession>
    <name>Q2GSY7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226844.1">
        <property type="nucleotide sequence ID" value="XM_001226843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSY7"/>
    <dbReference type="STRING" id="306901.Q2GSY7"/>
    <dbReference type="GeneID" id="4395206"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08917"/>
    <dbReference type="HOGENOM" id="CLU_868788_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSY7"/>
    <dbReference type="OrthoDB" id="4589207at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="35207" checksum="E4BB93D763B5CBED" modified="2006-03-21" version="1">MEAPSLPQIATAGSVAEKRERIASISAVLVAPPCNISRRQKLRSPLENSMHDPTYTKATPKAWTFYVHADCWDLVACRVANPTACATAFCNSLLTTYRDHITASPISTSQPRLSSGSPRLTTTPTPPGRNARRANMHQLDSFDGLAAELGLEHLPSIHEPISLEQLNLFSSTTAPTRRPLTHTHTTTTNNPDPFSTLPPELLHLLAEHTPTPTLLHLRIASRAVASVSGLASLPRSFWRSRFGPAFEMGFALPARVERELDWRGLYFLMGRGLRRYCGEVGGSRGERPLLARLAKRRFWWARLGKVVGLGVDGGLCESFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GT58</accession>
    <name>Q2GT58_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial genome maintenance protein MGM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_08846</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGM101 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226773.1">
        <property type="nucleotide sequence ID" value="XM_001226772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GT58"/>
    <dbReference type="FunCoup" id="Q2GT58">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GT58"/>
    <dbReference type="GeneID" id="4395785"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08846"/>
    <dbReference type="eggNOG" id="ENOG502RXU4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028692_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GT58"/>
    <dbReference type="OMA" id="REWVLIC"/>
    <dbReference type="OrthoDB" id="17164at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009446">
        <property type="entry name" value="Mgm101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404:SF0">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06420">
        <property type="entry name" value="Mgm101p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="19"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ84832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="302" mass="32580" checksum="C1D9A0CF62612508" modified="2006-03-21" version="1">MPTQYLRFPARRSPLLKQLARAASSSSYTPRPRTATSSIPASRARAVPAAKPATPAAAAPAAPAAPAAPTNPVLDPQAAMPPPATIEDVDPQLAAEIPTPESSGTRAPSAAFATALSGGPQGNGNNIDWSSSFHGLSTTPFSPETASVLMQRLDPYDIEVKPDGIIYLPEIKYRRILNRAFGPGGWGLAPRGELVVGEKVVTREYALVVHGRFIAQARGECQYFSEETIPTAGEGCKSNALLRCCKDLGIASELWDPRFIRDFKKAHCQELWVEHVVNKKRRQIWTRKDGEPAYPYKAAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTK3</accession>
    <name>Q2GTK3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ureidoglycolate hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_08701</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(S)-ureidoglycolate = urea + glyoxylate</text>
            <dbReference type="Rhea" id="RHEA:11304"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="4.3.2.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226628.1">
        <property type="nucleotide sequence ID" value="XM_001226627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTK3"/>
    <dbReference type="FunCoup" id="Q2GTK3">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GTK3"/>
    <dbReference type="GeneID" id="4394972"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08701"/>
    <dbReference type="eggNOG" id="ENOG502S1JQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1019418_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTK3"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004848">
        <property type="term" value="F:ureidoglycolate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050385">
        <property type="term" value="F:ureidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.480">
        <property type="entry name" value="Ureidoglycolate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007247">
        <property type="entry name" value="Ureidogly_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024060">
        <property type="entry name" value="Ureidoglycolate_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21221">
        <property type="entry name" value="UREIDOGLYCOLATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21221:SF1">
        <property type="entry name" value="UREIDOGLYCOLATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04115">
        <property type="entry name" value="Ureidogly_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ84687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="28420" checksum="05387EEB5278F719" modified="2006-03-21" version="1">MNDLARSTIIEAVPLTPEAFAPFGDVIENPRPDVHPSSADKRPHLPFDAIVANQGSAIKYQHLSRQINLYDQAPSGQPGSAVMNMFVCAARARIPDPPQLPAPAPSPARNPTTAEHQDSPHPQPSTFPITVLERHPYTTQTFIPLAANPTTQYLVIVAPTLPPPLNGPPKKGRGGGDPTRTHQPSALHRLPTPAAGGRPARPAPRPRLCGECRPGGHLRRGDLACAYGCAGREGDGGGLCRGAVCEWGGGGGLSGGGFEGGDVGRAWGGRAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTQ6</accession>
    <name>Q2GTQ6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226575.1">
        <property type="nucleotide sequence ID" value="XM_001226574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTQ6"/>
    <dbReference type="GeneID" id="4395344"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08648"/>
    <dbReference type="eggNOG" id="ENOG502SJ3D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028539_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GTQ6"/>
    <dbReference type="OMA" id="HFAFWAW"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF63">
        <property type="entry name" value="GLYCOSYL TRANSFERASE CAP10 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="152"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="462" mass="51926" checksum="A0E1FDDE53BC1919" modified="2006-03-21" version="1">MGEKTRFQMLMRPRPRSRQNRRQLRQATLLLGGALTLYCFLFVWRTPQPASASARAGKPSLPPEVLNNLSLDEGQCNAYFPGLTKEIDDVVAEGPFPVKQTGDMGPLQGRIKDGQIHIIHAQRKSDLSQEMLNSRTASLHQLHRALLTSPTPLPDTIFTLNFQDQPFGTAWAYSRHADPQFVSKKDGHARTFLMPHFSFWAWNLPFIGSMGRAAEAIAELEAEYAGAWHGKIAKAVWRGTMWFNSVHSPRMRQNLVKEARGKPWADVEPLEWTSNGGGKGAAKTASNALPIEGFCRYKYIIHTEGIAYSGRFQFLQMCASVVLTPPIQWMQHVTHLARPLFSSDLDLKRGGSGKSWTPTEKVKRAWPMGYKPEEANIVFVAPDWSDLGETVAWLEEHPEIAEGIARRQRDMFVGGGYFSPAAETCYWRAMVRGWAKMARTEGQGWEDTEGITFEAFSLTNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTX2</accession>
    <name>Q2GTX2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-1,3-mannosyltransferase CMT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226509.1">
        <property type="nucleotide sequence ID" value="XM_001226508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTX2"/>
    <dbReference type="GeneID" id="4394939"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08582"/>
    <dbReference type="eggNOG" id="ENOG502QRBX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036740_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GTX2"/>
    <dbReference type="OMA" id="CYMGEPT"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF5">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE CMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208442" description="Alpha-1,3-mannosyltransferase CMT1" evidence="2">
        <location>
            <begin position="26"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="47980" checksum="F6B07EE176665B6D" modified="2006-03-21" version="1">MRRPSLLIWPTACLLLVAITLYVRRDRFTGTHFSPTDRLQPHVGGKHSSTQTGSLPTATSSGPHSTALPRLECPKFELSRYQQLQIHVTDNDAREATIRYFFALNLRQCVKLLPRLIGSVVEAMRFLGPRHCALSIVEGNSNDGTGEVLAALRPELEALGITYYFSTTTINPKKGDRIAALAQLRNLALQPLLDATDTDNPNQQPIPPTYNPATTTIIFLNDVAICPDDILELTLQHSTLNADMVCAMDWTYVGRDPTFYDVWIARSLAGGDSFFEIPPDGNWNSAWNLFWNDPVARGRFAVRQPFQVFSCWNGAAVFRAAPVLEGGVRFRRARKGECHQGEPELFCKDLWFGGWGRIAVVPVVNLEYSDEGGRKIKEAKGYASKWVGASEWRDEGIEWQAEPPEKVKCMAKYDDQFFEAWNKTQPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTX3</accession>
    <name>Q2GTX3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226508.1">
        <property type="nucleotide sequence ID" value="XM_001226507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTX3"/>
    <dbReference type="STRING" id="306901.Q2GTX3"/>
    <dbReference type="GeneID" id="4394938"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08581"/>
    <dbReference type="eggNOG" id="ENOG502SRWI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148835_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTX3"/>
    <dbReference type="OMA" id="MENLPPK"/>
    <dbReference type="OrthoDB" id="5279542at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="17561" checksum="89596570E25D2C10" modified="2006-03-21" version="1">MENLPPKYVSPPGTWRTKLGLRAGSVLCVIILAGLSGSLAANPRIEAGALLMVVLAPAIIVTFVWDVAEAACILKRGGNRGIHPGAIVAIDLLAWLGWAIVDLMLSTFGVISRPRYMIQDYSGYDNDRYQYDESKVTPEDRALETEIQGKGRAMIVFGVITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUR1</accession>
    <name>Q2GUR1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ87040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225949.1">
        <property type="nucleotide sequence ID" value="XM_001225948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUR1"/>
    <dbReference type="STRING" id="306901.Q2GUR1"/>
    <dbReference type="GeneID" id="4394496"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08293"/>
    <dbReference type="eggNOG" id="ENOG502RS68">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_506215_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUR1"/>
    <dbReference type="OrthoDB" id="4903265at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="538" mass="61016" checksum="A6198140B9486BE6" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV58</accession>
    <name>Q2GV58_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_08146</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225802.1">
        <property type="nucleotide sequence ID" value="XM_001225801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV58"/>
    <dbReference type="ESTHER" id="chagb-q2gv58">
        <property type="family name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="GeneID" id="4394160"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08146"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043694_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GV58"/>
    <dbReference type="OrthoDB" id="4583463at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="7"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="79"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ86893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="432" mass="46122" checksum="4F2183D15D5D2B64" modified="2006-03-21" version="1">MRSTQNEDIPRRVFQTIASELHVPVDEFEQGDTEFSELGVDSLVAPSIIAKIARATAIQLPEDIFETTETVAGLRQHLATLAPPPPPPPPPPPPLPLPPTSTPTVSPPILIRRATITTTKKPNNTNTNPNTNPTPPRNLFLLPDGSGAAMAYARLPALPHTHIYALNSPFLPTTTTNTNTTTTTAYTCTLPQLAAAWAASITALQPRGPYLLGGWSAGGYYAYEVARWLARRGQVVHALVLVDSPCRVRFGALPLGVVRYLAGRGLMGDWGGVGGGGKRGGGGGKGGREGAPEWLVRHFEGTLRAVEAYVPEGFADRLGEGVVVPRVYIIWASEAVVGRGEVEAAGLDPDVEVTRMLLEPRSDFGPNGWDTLFPDGTELVIGTIPCNHFDIVHPPNVEMFGSLLGDIANPKGEAAWVNGWRKLTGGVVESQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVE2</accession>
    <name>Q2GVE2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225718.1">
        <property type="nucleotide sequence ID" value="XM_001225717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVE2"/>
    <dbReference type="STRING" id="306901.Q2GVE2"/>
    <dbReference type="GeneID" id="4394525"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08062"/>
    <dbReference type="eggNOG" id="ENOG502SS9Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114608_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GVE2"/>
    <dbReference type="OMA" id="WRQCASG"/>
    <dbReference type="OrthoDB" id="2865667at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="19876" checksum="9B5ADB2418F1AF40" modified="2006-03-21" version="1">MPTALGLTTDKSPHAQKSGDGPHVSSSTTMGSNARLDTISKRNHAAAREMETLLWRALCDEPETLREYLAHDCVMINPLLAPRGSCQPLSKDTQPSVVDVLQAGAGNKFRGFRFHGEPLVVEVDLMAVALVYKISLFRQGRKGVREVVASVGSTWRQTAGADWLLVQFHVAYADDDEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GW23</accession>
    <name>Q2GW23_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_07831</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225487.1">
        <property type="nucleotide sequence ID" value="XM_001225486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GW23"/>
    <dbReference type="FunCoup" id="Q2GW23">
        <property type="interactions" value="265"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GW23"/>
    <dbReference type="GeneID" id="4393187"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07831"/>
    <dbReference type="eggNOG" id="KOG1624">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041575_4_0_1"/>
    <dbReference type="InParanoid" id="Q2GW23"/>
    <dbReference type="OMA" id="KTFGPHP"/>
    <dbReference type="OrthoDB" id="275876at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000016">
        <property type="entry name" value="60S ribosomal protein L4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="110"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ86578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="319" mass="35491" checksum="71CFC873DBCC6B28" modified="2006-03-21" version="1">MAGKGMKSLSEAMRGLSLAAQPCRALPSQQVYAACRRSMATAVETKPTNITRSVSEAWNPLTTVPVTIHAFPTLEPRSLESWSTKHLHLPLRRDILHLAVVYEGDKTRQGTASSKTRFEVHGSHRKLRPQKGSGRARVGIKQSPLMKGGGKTFGPKPRDFSTKLNRKVYDLAWRTALSYRYRRGELIVTEDGLELPLPEEFLQLAESGAMGRELEDSFISKYVGELMTALQWDKDNGRTTFITGDRRPNLFTGLDIAGENGRALELEDVDVKDLLETGRIVIERTALREMIKEHSSDLISRVAVKGLSAKPTLGQVLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWB2</accession>
    <name>Q2GWB2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-3' exoribonuclease 1</fullName>
            <ecNumber evidence="5">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_07742</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the 5'-3' exonuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="5"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225398.1">
        <property type="nucleotide sequence ID" value="XM_001225397.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2GWB2">
        <property type="interactions" value="800"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GWB2"/>
    <dbReference type="GeneID" id="4393464"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07742"/>
    <dbReference type="eggNOG" id="KOG2045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001581_1_2_1"/>
    <dbReference type="InParanoid" id="Q2GWB2"/>
    <dbReference type="OMA" id="VASWPWF"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016494">
        <property type="entry name" value="5_3_exoribonuclease_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047007">
        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006743">
        <property type="entry name" value="Exonuclease_Xnr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="10">
        <location>
            <begin position="718"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="11">
        <location>
            <begin position="910"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="9">
        <location>
            <begin position="1153"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1265"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1283"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1305"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1319"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1395"/>
            <end position="1411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ86489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1420" mass="159699" checksum="3260B7CE37DCEFFF" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWI0</accession>
    <name>Q2GWI0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_07674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225330.1">
        <property type="nucleotide sequence ID" value="XM_001225329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWI0"/>
    <dbReference type="GeneID" id="4393910"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07674"/>
    <dbReference type="eggNOG" id="ENOG502SJXQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057891_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GWI0"/>
    <dbReference type="OMA" id="ENNYLPC"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ86421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="167" mass="18512" checksum="8C5D55904F41E93E" modified="2006-03-21" version="1">MQAAHDHDVQLRAYGITLEDFSRAGFEFPFLDLSGDGYSSFRWAPAQLISATNDIAVEGSRAYGTIVSPAKYTPLCDAYKRLPNGNTYFRASSVASSEFVELEMARVSFPKFNPYPLELFKNITNQPTFANATSCDNMIRLFNTTMSVGEHAPVPVRGRIKSARSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXG4</accession>
    <name>Q2GXG4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_07340</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224996.1">
        <property type="nucleotide sequence ID" value="XM_001224995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXG4"/>
    <dbReference type="FunCoup" id="Q2GXG4">
        <property type="interactions" value="697"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GXG4"/>
    <dbReference type="GeneID" id="4393798"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07340"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014571_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GXG4"/>
    <dbReference type="OMA" id="LWETFLM"/>
    <dbReference type="OrthoDB" id="271164at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="BAR_Vps5p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000013">
        <property type="entry name" value="Putative Sorting nexin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000022">
        <property type="entry name" value="Sorting nexin 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035803">
        <property type="entry name" value="BAR_Vps5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="215"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ86087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="620" mass="66806" checksum="984E367A9B48CB7E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXI1</accession>
    <name>Q2GXI1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224979.1">
        <property type="nucleotide sequence ID" value="XM_001224978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXI1"/>
    <dbReference type="STRING" id="306901.Q2GXI1"/>
    <dbReference type="GeneID" id="4394077"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07323"/>
    <dbReference type="eggNOG" id="ENOG502QS87">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023635_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GXI1"/>
    <dbReference type="OMA" id="GRSNSYH"/>
    <dbReference type="OrthoDB" id="4898142at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="607" mass="66498" checksum="2D155856236CD668" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXL7</accession>
    <name>Q2GXL7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_07287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224943.1">
        <property type="nucleotide sequence ID" value="XM_001224942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXL7"/>
    <dbReference type="GeneID" id="4394279"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07287"/>
    <dbReference type="HOGENOM" id="CLU_2108745_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GXL7"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ86034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="115" mass="12805" checksum="7957D0E3BD13B58F" modified="2006-03-21" version="1">MPQLRRTASPGSRCTRKKHLDHFAKQYSSQSKWTLVIHYLRSTAEASFGSAVRHIRTRKHKSAGPMKAVAGMEDNSTYMYLLPANVMLSCMSTAPHQMVPEAGLTSSLIRGRRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYD3</accession>
    <name>Q2GYD3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224677.1">
        <property type="nucleotide sequence ID" value="XM_001224676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYD3"/>
    <dbReference type="STRING" id="306901.Q2GYD3"/>
    <dbReference type="GeneID" id="4393853"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07021"/>
    <dbReference type="eggNOG" id="ENOG502QYHN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004016_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYD3"/>
    <dbReference type="OMA" id="ECPSLCH"/>
    <dbReference type="OrthoDB" id="8436363at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF8">
        <property type="entry name" value="PAXILLIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="980"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="980"/>
            <end position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1123" mass="121397" checksum="B1127F274C4C1232" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYR2</accession>
    <name>Q2GYR2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_06892</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224548.1">
        <property type="nucleotide sequence ID" value="XM_001224547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYR2"/>
    <dbReference type="GeneID" id="4393216"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06892"/>
    <dbReference type="eggNOG" id="ENOG502RJ8G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093556_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYR2"/>
    <dbReference type="OrthoDB" id="4562708at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="204"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ85639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="259" mass="29020" checksum="1B8D91863CBBD8ED" modified="2006-03-21" version="1">MQLTVGPESLVALTADGTIRCLLNTRYPLPSRQSSAALALADQLVTELARAVTAQLGPPPVPSSATAAEDGVPSTDSVTGYTADTRLHAVLLERNRLFVCFDLFLPDCKPEVRRRVDESIAQPIHILLKSGNICRMMRSPGLDREVAGRYTEFQEVDKGPRPYFDDDLSPAFYVNGKRYEGRLEDYGPEFEFPLDEDDEAKDETWEPQEVCGDRIADDGFPELLVRWKSGRETWEDYDDVAKTVPEALVEYKRRCGQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZ19</accession>
    <name>Q2GZ19_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">5'-Nucleotidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_05227</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224441.1">
        <property type="nucleotide sequence ID" value="XM_001224440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZ19"/>
    <dbReference type="STRING" id="306901.Q2GZ19"/>
    <dbReference type="GeneID" id="4391813"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05227"/>
    <dbReference type="eggNOG" id="KOG4419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005854_7_2_1"/>
    <dbReference type="InParanoid" id="Q2GZ19"/>
    <dbReference type="OMA" id="WLATINS"/>
    <dbReference type="OrthoDB" id="10252235at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07406">
        <property type="entry name" value="MPP_CG11883_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041821">
        <property type="entry name" value="CG11883_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF48">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="29"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="6">
        <location>
            <begin position="294"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="517"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ88608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="637" mass="70108" checksum="E93BEC31817EAB32" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZX2</accession>
    <name>Q2GZX2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_04924</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224138.1">
        <property type="nucleotide sequence ID" value="XM_001224137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZX2"/>
    <dbReference type="STRING" id="306901.Q2GZX2"/>
    <dbReference type="GeneID" id="4393088"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04924"/>
    <dbReference type="eggNOG" id="KOG1200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="InParanoid" id="Q2GZX2"/>
    <dbReference type="OMA" id="HGNAGQI"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032787">
        <property type="term" value="P:monocarboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ88305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="291" mass="30407" checksum="280A56FA68AC1CF3" modified="2006-03-21" version="1">MSERINQIARQLNYPKGLLAGQVAIITGSGQGIGAECARLFANEGAKVVVSDIDAAKAEDVASQIRANGGEALAVAGDLLKDECITELIKKAAEFGNAKIHILVNNAGFTWDAVIHKMTDQQWDTMLAMHGTVPFKLVREAAPYFRVRDGEARNIVNISSTSGLHGNAGQLNYAMAKAGVVGLTKTIAKEWGPAFGVRANTVAFGHIETRLTADKEDGAFVEVGGQKVALGIPGKQKKAAVEAAGAVPFVDIPLRRPGTATEAASAVLAIASPLSSYISGQTISVTGGRNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0I1</accession>
    <name>Q2H0I1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_04715</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223929.1">
        <property type="nucleotide sequence ID" value="XM_001223928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0I1"/>
    <dbReference type="STRING" id="306901.Q2H0I1"/>
    <dbReference type="GeneID" id="4392954"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04715"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043291_2_1_1"/>
    <dbReference type="InParanoid" id="Q2H0I1"/>
    <dbReference type="OMA" id="PKPQWKG"/>
    <dbReference type="OrthoDB" id="439993at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08029">
        <property type="entry name" value="LA_like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF140">
        <property type="entry name" value="ACHILLES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="6">
        <location>
            <begin position="72"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ88096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="339" mass="37121" checksum="A126CE74EEE44ADC" modified="2006-03-21" version="1">MSDAAIKEQTEAVTAAAEVQPVEETATAVEKADDGVQDAKNGEDKKAEGILKTTARINHKDFKQNRKYDPTTQPVSDDPVKIRAQVEFYFSDSNLPTDKFMWESTGGEENKPMPLKTIASFKRMRQFQPYSAVVAALRESTFLDIEGEEGEETLKRKTPYVSSNDAQRARVAASVYAKGFGDEEASTQQIKAGEIEPNTNRRNAFFEGKDRGSDRRGRGGRGGWGRDDRNGREGKSEGGENGHRNGFKGGRGRGRGGRGGRGFRGGRGGGRGRDNNNRDRDEKKSEETRQNTNDVQMPTIQSTATKNGDTNGKRAREDDSGEAPPAKKVDSKPEAVAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0K5</accession>
    <name>Q2H0K5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_04691</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223905.1">
        <property type="nucleotide sequence ID" value="XM_001223904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0K5"/>
    <dbReference type="STRING" id="306901.Q2H0K5"/>
    <dbReference type="GeneID" id="4391634"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04691"/>
    <dbReference type="eggNOG" id="ENOG502QUQ4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026011_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H0K5"/>
    <dbReference type="OMA" id="IDPHPLA"/>
    <dbReference type="OrthoDB" id="545910at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.590:FF:000010">
        <property type="entry name" value="GRF zinc finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF4">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="257"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="7">
        <location>
            <begin position="393"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="447"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="313"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ88072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="473" mass="53115" checksum="76900FB80E271DAE" modified="2006-03-21" version="1">MDAFVTRKKRKCSDSSISVSVTPRPQVGTEESSHQFNNEESTDVKLAILSSLHPAIDQETLLDILLAHDGDVEATSRTFKARLPKKPGTGSTVAAQSSLRSFAVNSADPELPSQPKRAKLLSRKGATLHLYDPVDISEHTPCTIIHNFLPAEEANALLKELIEESKSFEKITFKLFDNVVSSPHTSSFYVGSYEEMQEQKYEYVYNGSRLTDVRTLTPQLERVKARVQETVNREIQERIQTHYGGKKLKYQSPKPWNPNAAFVNCYNGPQESVGWHSDHLTYLGPRAVIGSLSLGVTREFRVRRILLQDDPVANDANPSSTNNSNNPDRGGQIAIHLPHNSLLVMHADMQEEWKHSITPTQAIDPHPVAGNRRINITYRHYRDGFHPRNTPICPCGVPVVLRVVTKKRENWGRYFWMCHAGNVPGKEACEFFRWAEFDDDGEPLVMKQDGGGKKEGLLVQHEGSKPDKGNSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0M6</accession>
    <name>Q2H0M6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223884.1">
        <property type="nucleotide sequence ID" value="XM_001223883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0M6"/>
    <dbReference type="GeneID" id="4391818"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04670"/>
    <dbReference type="HOGENOM" id="CLU_1731251_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H0M6"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="151" mass="15923" checksum="2E0E3C7A1EAB88BD" modified="2006-03-21" version="1">MGTTNNSWAPKPKPEEDEASPSTPDTTTTTATTTTPSTTTPANALPPPVPQKHHHQAIADPLAHFLAIPWTARLLTDPAAFGIVVSDRRPLASGDKQFVRSVLSSPTTVRACVTFFLRLPLVQGVAAQGVVPVSKSRALLQGWGSARRGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0T9</accession>
    <name>Q2H0T9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223821.1">
        <property type="nucleotide sequence ID" value="XM_001223820.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H0T9"/>
    <dbReference type="GeneID" id="4392111"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04607"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003430_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H0T9"/>
    <dbReference type="OMA" id="QLHTGFW"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050667">
        <property type="entry name" value="PPR-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939">
        <property type="entry name" value="MEMBRANE-ASSOCIATED SALT-INDUCIBLE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939:SF13">
        <property type="entry name" value="OS03G0201400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1180"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1197"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1220"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1238"/>
            <end position="1250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1290" mass="145985" checksum="89ABEB21D1DED05A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-03" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0U6</accession>
    <name>EIF3G_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Eukaryotic translation initiation factor 3 subunit G</fullName>
            <shortName evidence="1">eIF3g</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Eukaryotic translation initiation factor 3 RNA-binding subunit</fullName>
            <shortName evidence="1">eIF-3 RNA-binding subunit</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Translation initiation factor eIF3 p33 subunit homolog</fullName>
            <shortName evidence="1">eIF3 p33 homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TIF35</name>
        <name type="ORF">CHGG_04600</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
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    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-3 subunit G family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000365440" description="Eukaryotic translation initiation factor 3 subunit G">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
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        <location>
            <begin position="223"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="303" mass="33245" checksum="B1B3AF3310305450" modified="2006-03-21" version="1">MATQTKHDWADDEDLEETTTTTAPTTDLPPPQKIQNKDGTWTIIEYRINDLGQKVKATRRVRYVVRREVVNPRVAERKTWAKFGDSANDPKGPAPDTTTVGENIIFRPSVNWRKEAKDEANDPNAQAMKDKLKDKKVKCRICNGEHFTARCPYKDTMAPIGEAGPADVAAGMGDEPAAAGPAAAGAAGAGKKGSYVPPAMRAGAGGAQGERMGGKYGERDDLATLRVTNVSEMAEEQELRDMFERFGRVTRVFLAKDRDTGMAKGFAFISYADRDDAVKACNKMDGFGFRHLILRVEFAKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0Z7</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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            <taxon>Sordariomycetes</taxon>
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        </lineage>
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    <reference evidence="10" key="1">
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_001223762.1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04549"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SWIRM" evidence="7">
        <location>
            <begin position="119"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="8">
        <location>
            <begin position="298"/>
            <end position="349"/>
        </location>
    </feature>
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        <location>
            <begin position="299"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ87930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="574" mass="62464" checksum="7772424DB77B23CA" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1I6</accession>
    <name>Q2H1I6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_04360</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001223573.1"/>
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    <dbReference type="eggNOG" id="KOG4293">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_065428_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H1I6"/>
    <dbReference type="OMA" id="IGVWMIN"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF1">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209192" description="Cytochrome b561 domain-containing protein" evidence="9">
        <location>
            <begin position="26"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="10">
        <location>
            <begin position="86"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ87741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="266" mass="29101" checksum="595966106CB5771C" modified="2006-03-21" version="1">MIQRHTYHRAATLLAFSWLILTVSARVGGGSSDTTTNTDAASYNPSYNPSYSPYNPYNPNSGNPGAGAGGFNPGFDITQMMDYRRIHGILAATAMVVLFPVGSIIVRVVPGRFAVWVHAGFQMLAWAVYVAAVGMGIYLFENPDTRYHPIIGLVLLVLLIVQPVVGFIHHRVFKKVQKRQVWSYVHLTLGRVGISLGIINGGLGLYLSGASAYHKRVYGIVAGVMWALWMGVAVWSEVRRLRKNRKGTETVVSKGPPAESARVSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1Z7</accession>
    <name>Q2H1Z7_CHAGB</name>
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        <recommendedName>
            <fullName evidence="9">PQ loop repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_04199</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223413.1">
        <property type="nucleotide sequence ID" value="XM_001223412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1Z7"/>
    <dbReference type="GeneID" id="4392973"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04199"/>
    <dbReference type="eggNOG" id="ENOG502RXTU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033734_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H1Z7"/>
    <dbReference type="OMA" id="WWYALTI"/>
    <dbReference type="OrthoDB" id="19344at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF11">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ87580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="36930" checksum="27B6655C87E58D93" modified="2006-03-21" version="1">MDAWIGEDRCEELRDLSVVNLIVSIVIVIGMLISYLPQHFRIIKRRTSEGISPWFVLLGTTSGTSAFANILLLPKSRQDVACCKELETFHCVAGLLGIAQLGVQWICFAFIFVLFLVFFRYHSADDVENEEVDDEAHPRWQTALLVASLTLLHGLAVIVVTGVLSTTAKQHLPTWANVLGVMAALLAAVQYIPQIWTTYHLKHVGSLSIPMMCIQTPGGFVFAASLFARLGWAGWSSWGIFVLTATMQGALLSLAIYYEIQANANGTNTSKSPSPLLGRSHHGNGFDDEVHANGSSNGRSDLQATEDQDLDLAADTTPLLHASRTGDSQRNYDTNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H204</accession>
    <name>Q2H204_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cyclin-dependent kinase</fullName>
            <ecNumber evidence="1">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_04192</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="1"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223406.1">
        <property type="nucleotide sequence ID" value="XM_001223405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H204"/>
    <dbReference type="STRING" id="306901.Q2H204"/>
    <dbReference type="GeneID" id="4392659"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04192"/>
    <dbReference type="eggNOG" id="KOG0659">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_6_1"/>
    <dbReference type="InParanoid" id="Q2H204"/>
    <dbReference type="OrthoDB" id="413582at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF576">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CSK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="96"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ87573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="327" mass="36019" checksum="FB71609A10F412B8" modified="2006-03-21" version="1">MSHVEASGQPWHRYQIEWNLESLMFPVLTSRGLSQSAFEIENEAYKTSISREEYNAACNPPTSSVEPPESALAALATPAPEANDRESSPGITIGDYHDCHYIASGVTAAVYRAQARALKVIVETHNIEPHSPQREAKMLASLRASNAPNIIPLLETFRDPQTQNFVLLSRPALGVRHEARTQKVLEVGTGVYRAPETLFGDRAYGPGIDLWASGTTLAECFLRRPLFDSPPAHEDGSQLGLVLSLFQTLGTPTPATWPEARAFRTPPFEMYRVFEGRVAREGWEGLVPGAEGGWRGLVEGMVRFESGWRVTAGEALEFPRMKGEAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2D9</accession>
    <name>Q2H2D9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223271.1">
        <property type="nucleotide sequence ID" value="XM_001223270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2D9"/>
    <dbReference type="STRING" id="306901.Q2H2D9"/>
    <dbReference type="GeneID" id="4392918"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04057"/>
    <dbReference type="eggNOG" id="KOG1471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014001_4_2_1"/>
    <dbReference type="InParanoid" id="Q2H2D9"/>
    <dbReference type="OMA" id="DWRKAND"/>
    <dbReference type="OrthoDB" id="30289at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF3">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="102"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="423" mass="47447" checksum="1849DE3BEE1C8B21" modified="2006-03-21" version="1">MADAPADKTTSGGVADVGYPNGHLGHLTEGEENQLKAFKIFLEDKGLYKSGPPPSHDDQTLLRFLRARKWVVNDAYQQFKDTEEWRQANHLDVLYDTIDVDAYEQTRRLYPQWTGRRDRRGIPLYLYQIRHLDSKTVSAYEKASESTNVSKAETDGSTPQRLLRLFALYENLTRFAQPLCTELKDREHSGTPITLSTNIVDVSQVSLRMFWNLKAHMQAASTLATAHYPETLDRIFIIGAPYFFSTVWGWIKRWFDPITVSKIFILSAAEVRPTLESFIEPRNIPKQYGGELEFEFFDRPNVDPAIKEAIRWEAGYTDFPEGPVYWVPVDDGARLACMAVGSKDGKERRERVGTIAVTFPKGEIAAQPAAETVAAAAPPAEAIVDRIQKLSITENSVAGEIEEKVATSAGGQQPEQKTTAVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2M9</accession>
    <name>Q2H2M9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_03967</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223181.1">
        <property type="nucleotide sequence ID" value="XM_001223180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2M9"/>
    <dbReference type="FunCoup" id="Q2H2M9">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H2M9"/>
    <dbReference type="ESTHER" id="chagb-q2h2m9">
        <property type="family name" value="Homoserine_transacetylase"/>
    </dbReference>
    <dbReference type="MEROPS" id="S33.A41"/>
    <dbReference type="GeneID" id="4392528"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03967"/>
    <dbReference type="eggNOG" id="ENOG502QRIX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028760_5_0_1"/>
    <dbReference type="InParanoid" id="Q2H2M9"/>
    <dbReference type="OMA" id="LGGCQGT"/>
    <dbReference type="OrthoDB" id="191364at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF11">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="67"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="251"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ87348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="487" mass="53494" checksum="E984342020029328" modified="2006-03-21" version="1">MTPDSVQNGPRPVYERIHSQPENPFAELIPHQQIAVIPSFTLESGVTLSNVPVAYTTRGTLSPDADNVMVICHALTGSADVGDWWGPLLGGPGRAFDTSRFFVVCMNSLGSPYGTASPVTAKDGDPSKGRYGPEFPLTTIRDDVQLHKLLLDELGVKQVAAVIGGSLGGMFVLEWAYFGKDYVRCIVPIATSSRHSAWGISWGEAQRQSIYADPKYEDGYYSFSDPPSTGLGAARMAALLTYRSRNSFEARFGRNIPDPSRRQTIRERPTPSTPSEAHFHTHNDGHKWTRSPSRKNSDGEQAPKYDQGGDASLDPQFHGPKNGSLTGGEVMPTSSTYFSAQSYLRYQGGKFVKRFDSNCYIAMTRKLDTHDVSRGRAGTIAEALAMIEQPTLVLGIESDGLFTFAEQEELAQHIKNARLERIDSPEGHDAFLLQFEQVNHYTLDFLREALPDIMNKNTNGVAVESSVGELTKSSTFGEAEVEDITAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3R5</accession>
    <name>Q2H3R5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_06700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222795.1">
        <property type="nucleotide sequence ID" value="XM_001222794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3R5"/>
    <dbReference type="GeneID" id="4390867"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06700"/>
    <dbReference type="eggNOG" id="ENOG502SJX7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021158_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3R5"/>
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    <dbReference type="OrthoDB" id="3554464at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ90081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35754" checksum="3E93D77A1FD04B13" modified="2006-03-21" version="1">MPSRDDWPKMPDGYDFDGRHLLTLVRYGSSPFDNEWDVNLLIQEMEDKFLALVVDIPQVSKGYNHYSCLLSRAAHIRASLYRFKVPPNFASAWLRQRLFEQKPDLLPIPVGPTREFCVALLASKTEATLKDIGDMTGCEDDDNSVGPIVAAAKKSLLRLIPHIMPKGDDNMDLYRFVLDHGDFGIHNMLIAMDKNNQPLVTSLFDWETGHIVPAILSDPLMAVTVDLVAGEDAAPSLTRLPDTATADLLEETSTWSRQYFKALFFEAPEYERVIRAGGDARHIWFTLQAWSGDKPGKYFGKLGAWAERRLQELGVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4B7</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">CHGG_06498</name>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ89879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4B7"/>
    <dbReference type="GeneID" id="4390722"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06498"/>
    <dbReference type="eggNOG" id="ENOG502R7SI">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1337364_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4B7"/>
    <dbReference type="OMA" id="MHEENTH"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="205" mass="21066" checksum="E5EECBEE7490606E" modified="2006-03-21" version="1">MKANTHRPAASSPHARLPTTASKSRPLSRSAPANRGVSHSHLGTGQAFPPPTKVDDQHRLHDQRPDHHQLRPGSDPSGPDHSIVLTTVTIAVSTTICPVTETEAPPPPPPPPTTVVPPPPPPPPPTHTTHPHPPPPPPPPPPASSTKSAEAPPPPPPPPPPPPPPPVVTSPPTLSVGTTALPSKTATSQTPFTGGAADLRRAAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4I4</accession>
    <name>Q2H4I4_CHAGB</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222526.1">
        <property type="nucleotide sequence ID" value="XM_001222525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4I4"/>
    <dbReference type="GeneID" id="4390897"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06431"/>
    <dbReference type="eggNOG" id="ENOG502T5ZI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3159921_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4I4"/>
    <dbReference type="OrthoDB" id="5234231at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="48" mass="5332" checksum="60229EE2A733617B" modified="2006-03-21" version="1">MSVCYCANFYVLRSGTSLTPGRLPEDSLWSLSQAQTRDPQPENRADGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4J4</accession>
    <name>Q2H4J4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_06421</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR59 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001222515.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H4J4"/>
    <dbReference type="GeneID" id="4390619"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06421"/>
    <dbReference type="eggNOG" id="KOG0309">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001497_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H4J4"/>
    <dbReference type="OMA" id="TDVCAHN"/>
    <dbReference type="OrthoDB" id="311712at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc_UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049567">
        <property type="entry name" value="WDR59-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="RWD" evidence="4">
        <location>
            <begin position="425"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="549"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="791"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1194"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="549"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="570"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="807"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="841"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1221"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1260"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1310"/>
            <end position="1323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ89802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1401" mass="151154" checksum="C568B5101C8D6961" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4J7</accession>
    <name>Q2H4J7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89799.1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="128" mass="13654" checksum="0181D16EDBCF2CA8" modified="2006-03-21" version="1">MCGLQHRAHRGSLSFQQPPLPAAEHRPEPARASRAGPGGTGEQTVRLPQDSLTGEPSPGEPATHTGIRFVVRFKTQEACHPLADFYPVTGIASVISAGPWGNDGGDRSLRLVSGRWQTGITILRLEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4P9</accession>
    <name>Q2H4P9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222461.1">
        <property type="nucleotide sequence ID" value="XM_001222460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4P9"/>
    <dbReference type="GeneID" id="4391272"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06366"/>
    <dbReference type="eggNOG" id="ENOG502RJ3Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_626988_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4P9"/>
    <dbReference type="OrthoDB" id="10422102at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="47887" checksum="2C7F75027645848C" modified="2006-03-21" version="1">MEGNPTPPRPMTGVPGDRKIAAAIGQKTTIPGTSGAPDPTVRRPITKSIPLRIITQNLAALSIGKKRPLDDLAASVEACGLSGDEPDRRVVAKKLCGGLCGGDSIDSDELVAMWMEGRAHSCHSVRNGLRAPPPSPIFVFDDTSSDTSSEEAGSGEASDSWETVEESGAGGDGDEVRSGGGKDSDCNDGSYEPSEASTESDEGSEWDSDDWEGDLDFLRNVGWWNNHMEAPTFKFVKLGIKGEAVGQNFPPIPTFVRCSLCLDTQLSILGLPIFKPIYHDDIRHLKPGVILICGHMFCKACWTRYVEDYHDSIVDRDDDGALEQIEGSPHEEDDIKMSYDDDPCDETEDGEALEEAEEDEKEDGEAEDEEREEEEGEEEEGEEEEGVEEEEGEEEDDDHDDDHDEEGEQLPPCLSCPICHYGLVYSNGFFQSKDWNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H545</accession>
    <name>Q2H545_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222315.1">
        <property type="nucleotide sequence ID" value="XM_001222314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H545"/>
    <dbReference type="GeneID" id="4390357"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06220"/>
    <dbReference type="HOGENOM" id="CLU_2468858_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H545"/>
    <dbReference type="OrthoDB" id="10442667at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="88" mass="8868" checksum="A9FA20A16F64C671" modified="2006-03-21" version="1">MVSVGHAEVSGSSSEAAETPRQAHALDNKANAEARGAGQTTDSSSSPVSDLNDGDYTTGGSLFPGSHDTTDTYAWALASGEAQAGVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5N9</accession>
    <name>Q2H5N9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_06026</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2005-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Giovannoni S.J."/>
                <person name="Cho J.-C."/>
                <person name="Ferriera S."/>
                <person name="Johnson J."/>
                <person name="Kravitz S."/>
                <person name="Halpern A."/>
                <person name="Remington K."/>
                <person name="Beeson K."/>
                <person name="Tran B."/>
                <person name="Rogers Y.-H."/>
                <person name="Friedman R."/>
                <person name="Venter J.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 148.51</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2006-02" db="EMBL/GenBank/DDBJ databases">
            <title>Annotation of the Chaetomium globosum CBS 148.51 Genome.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Birren B."/>
                <person name="Lander E."/>
                <person name="Galagan J."/>
                <person name="Devon K."/>
                <person name="Nusbaum C."/>
                <person name="Ma L.-J."/>
                <person name="Jaffe D."/>
                <person name="Butler J."/>
                <person name="Alvarez P."/>
                <person name="Gnerre S."/>
                <person name="Grabherr M."/>
                <person name="Kleber M."/>
                <person name="Mauceli E."/>
                <person name="Brockman W."/>
                <person name="Rounsley S."/>
                <person name="Young S."/>
                <person name="LaButti K."/>
                <person name="Pushparaj V."/>
                <person name="DeCaprio D."/>
                <person name="Crawford M."/>
                <person name="Koehrsen M."/>
                <person name="Engels R."/>
                <person name="Montgomery P."/>
                <person name="Pearson M."/>
                <person name="Howarth C."/>
                <person name="Kodira C."/>
                <person name="Yandava C."/>
                <person name="Zeng Q."/>
                <person name="Alvarado L."/>
                <person name="Oleary S."/>
                <person name="Untereiner W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 148.51</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222121.1">
        <property type="nucleotide sequence ID" value="XM_001222120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5N9"/>
    <dbReference type="GeneID" id="4390466"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06026"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H5N9"/>
    <dbReference type="OMA" id="RMGRTHE"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF10">
        <property type="entry name" value="CHAIN DEHYDROGENASE_OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ89407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="296" mass="32120" checksum="0E08565D0289FB58" modified="2006-03-21" version="1">MNTATRTLRLAARQRFSTRAAQAIPNITPLTRLTFVRAMHTPRKEQQVWPTDTTSPEPRSHPNKDNKPAIDENVGKKGFADFNVAGKALVEAGGKVYALDRSPEPDEQWAEAIARVVPSAGGSLHYRQQNVADTAHLDSLIASIADENGRLDGAVAAAGVQQVTEALDYTPEDVARMLDVNYTGVFMTAQSVARQMFRYKMRGSICLIASMSGMVANKGLLSPVYNSSKAAVIQLAKNLAMEWSPVREDGTGGIRVNCISPGHILTPMVLKNFEEVPGLRETWEGENMIGKAGGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5S0</accession>
    <name>Q2H5S0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_05995</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EAQ89376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001222089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5S0"/>
    <dbReference type="FunCoup" id="Q2H5S0">
        <property type="interactions" value="1057"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H5S0"/>
    <dbReference type="GeneID" id="4390951"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05995"/>
    <dbReference type="eggNOG" id="KOG0651">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_2_2_1"/>
    <dbReference type="InParanoid" id="Q2H5S0"/>
    <dbReference type="OMA" id="DHEPCVI"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
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    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="168"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ89376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="391" mass="43742" checksum="B755817D8C63355E" modified="2006-03-21" version="1">MASDPEREQALASFKKKLIESREWETKLKNLRLDIKGLQNEFDQTEDNIKALQSVGQIIGEVLKQLDEERFIVKASSGPRYVVGCRSKVDRAKMKQGTRVALDMTTLTIMRMLPREVDPLVYNMSLEDPGQVSFAGIGGLNDQIRELREVIELPLKNPELFLRVGIKPPKGVLLYGPPGTGKTLLARAVASSLETNFLKVVSSAIVDKYIGESARLIREMFGYAKEHEPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQLDGFDYLGKTKIIMATNRPDTLDPALLRAGRLDRKIEIPLPNEVGRLEILKIHAAGVSKDGEIDFESVVKMSDGLNGADLRNVVTEAGLFAIKDDRDAINQDDFNKAVRKLVEAKKLEGKLEYQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H669</accession>
    <name>Q2H669_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001221940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H669"/>
    <dbReference type="STRING" id="306901.Q2H669"/>
    <dbReference type="GeneID" id="4390904"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05846"/>
    <dbReference type="eggNOG" id="ENOG502SDRZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008005_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H669"/>
    <dbReference type="OMA" id="LNVMEGN"/>
    <dbReference type="OrthoDB" id="3438840at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="574"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="578"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="603"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="687"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="718"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="911" mass="97296" checksum="A4B6C42E1FDE1CA4" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H689</accession>
    <name>Q2H689_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_05826</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221921.1">
        <property type="nucleotide sequence ID" value="XM_001221920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H689"/>
    <dbReference type="STRING" id="306901.Q2H689"/>
    <dbReference type="GeneID" id="4390780"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05826"/>
    <dbReference type="eggNOG" id="KOG2930">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115512_4_2_1"/>
    <dbReference type="InParanoid" id="Q2H689"/>
    <dbReference type="OMA" id="SSMYSTH"/>
    <dbReference type="OrthoDB" id="8962942at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ89207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="87" mass="9545" checksum="D7E26BCB2CB2ECD3" modified="2006-03-21" version="1">MADVEMPDAPTSAPTSTAVTKKKGGVDGEGKEGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQATRSIFTAFRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6F5</accession>
    <name>Q2H6F5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221855.1">
        <property type="nucleotide sequence ID" value="XM_001221854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6F5"/>
    <dbReference type="STRING" id="306901.Q2H6F5"/>
    <dbReference type="GeneID" id="4391061"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05760"/>
    <dbReference type="eggNOG" id="ENOG502SX2A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052402_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6F5"/>
    <dbReference type="OMA" id="FYFGCWS"/>
    <dbReference type="OrthoDB" id="4140442at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="412" mass="44842" checksum="2846E89FD7CEA356" modified="2006-03-21" version="1">MPINWVGALRTPIAGAAAKPQPRLNIARHRQKFGPANDRTLLYLSIGKPIGPVNFKDIQMASFSRGFGPRLLLVVRLQVPSECAATQARQLLRARFSTTRLLQKGGRSHRLANKPTPKPSPATAPKPKAATPKPAPKAKTAPILGTTTAIPAARPLATSSGYAEQLALKGRTLLYESPSHFWFRAGCFSSATFCVSYAVYQYWTVILHPPEGLMWWIPHAFGVILVFMAGMGAYFVTGAGRIVRSIEAVPASAVAAAAAKQIAGAGGRSSPVYIQVTTRRMGPFMPAKKHLLPPEEVLLPFRMYSVFGGEMGGQKAMSLAERVRLERAAQEARIAERKYTMDHLLTAPFRDAKKAFGGAWEGIVRSFNRGGFVKIQLGKQDYKLDVTGGWALDNGRAMDRLLPVRPNAMSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6S2</accession>
    <name>Q2H6S2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_05643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221738.1">
        <property type="nucleotide sequence ID" value="XM_001221737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6S2"/>
    <dbReference type="GeneID" id="4390914"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05643"/>
    <dbReference type="HOGENOM" id="CLU_2558102_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6S2"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="82" mass="9541" checksum="0CB8553B971D0D06" modified="2006-03-21" version="1">MAKPRPFWRFTKLRSQWTEAADHGSAAGVRSRQRRGWTTALNSYERRQYRLPIPEHEHRWPVYLGHGYPRGSVDPSLPPGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H765</accession>
    <name>Q2H765_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA repair protein RAD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_05500</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221595.1">
        <property type="nucleotide sequence ID" value="XM_001221594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H765"/>
    <dbReference type="FunCoup" id="Q2H765">
        <property type="interactions" value="895"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H765"/>
    <dbReference type="GeneID" id="4390883"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05500"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_2_5_1"/>
    <dbReference type="InParanoid" id="Q2H765"/>
    <dbReference type="OMA" id="KVEPWSN"/>
    <dbReference type="OrthoDB" id="2801544at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16572">
        <property type="entry name" value="RING-HC_SpRad8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="332"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="726"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="820"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="199"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ88881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="982" mass="110569" checksum="653B746C375604D8" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H781</accession>
    <name>Q2H781_CHAGB</name>
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        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_05484</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221579.1">
        <property type="nucleotide sequence ID" value="XM_001221578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H781"/>
    <dbReference type="STRING" id="306901.Q2H781"/>
    <dbReference type="GeneID" id="4390024"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05484"/>
    <dbReference type="eggNOG" id="KOG4711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001788_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H781"/>
    <dbReference type="OMA" id="YMENLMH"/>
    <dbReference type="OrthoDB" id="2274698at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF4">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="631"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="660"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="683"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="707"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="731"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="7">
        <location>
            <begin position="57"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="8">
        <location>
            <begin position="655"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="857"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="858"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="881"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ88865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1080" mass="119185" checksum="798EDD9BAAF43D22" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7Y0</accession>
    <name>Q2H7Y0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230190.1">
        <property type="nucleotide sequence ID" value="XM_001230189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7Y0"/>
    <dbReference type="GeneID" id="4388720"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03674"/>
    <dbReference type="eggNOG" id="ENOG502SK6C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009650_2_2_1"/>
    <dbReference type="InParanoid" id="Q2H7Y0"/>
    <dbReference type="OMA" id="ARIYNPG"/>
    <dbReference type="OrthoDB" id="3353407at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021822">
        <property type="entry name" value="DUF3405"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11885">
        <property type="entry name" value="DUF3405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="621"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="661" mass="74421" checksum="FD216C031012CCF5" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8B5</accession>
    <name>Q2H8B5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_03539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230055.1">
        <property type="nucleotide sequence ID" value="XM_001230054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8B5"/>
    <dbReference type="GeneID" id="4388515"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03539"/>
    <dbReference type="HOGENOM" id="CLU_1396148_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8B5"/>
    <dbReference type="OrthoDB" id="4177236at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF48">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ91604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21953" checksum="AC08F86F68A87EB6" modified="2006-03-21" version="1">MATRPTLPYVAPDEILPSPLPSVEEILASPCLFDGVFRRVGHHFMVKHGKSTGALLQEGQNMLFVEQSASLLRIPKNYAISSHEKTNMDFIVMEYIPGKLLDRIDWCTLTVSQKTNITSQLRRGLDELRSIPSPEQWIDAMWRCAVGVKSATDSKLPNISRLRKDYHLVFKGYKPVFTHADLGPGHVVLRNVVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8D0</accession>
    <name>Q2H8D0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_03524</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230040.1">
        <property type="nucleotide sequence ID" value="XM_001230039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8D0"/>
    <dbReference type="FunCoup" id="Q2H8D0">
        <property type="interactions" value="599"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H8D0"/>
    <dbReference type="GeneID" id="4388529"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03524"/>
    <dbReference type="eggNOG" id="KOG3041">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062658_0_2_1"/>
    <dbReference type="InParanoid" id="Q2H8D0"/>
    <dbReference type="OMA" id="AKLYHWA"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF26">
        <property type="entry name" value="ADP-RIBOSE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="56"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ91589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="175" mass="19021" checksum="2D706A782A6F25CC" modified="2006-03-21" version="1">MSQPQQQTPTITSITDLPTTDAKWITLQRIAYVDQTGQPRTWECAARKTRARSAGVDAVAMGNVLLHPSRPPSTLLVIQYRPPLDAFTVEWPAGLVDEGETAEQAAVREFKEETGYECAVVGVSPVQAADPGLSSANMKMVMVEVRLGEGEELPEQRLEDGEHIQRVVVPVGGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8T0</accession>
    <name>Q2H8T0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229890.1">
        <property type="nucleotide sequence ID" value="XM_001229889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8T0"/>
    <dbReference type="STRING" id="306901.Q2H8T0"/>
    <dbReference type="GeneID" id="4388488"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03374"/>
    <dbReference type="eggNOG" id="ENOG502SVPD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022039_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8T0"/>
    <dbReference type="OMA" id="SQMMVER"/>
    <dbReference type="OrthoDB" id="5423493at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="431" mass="47601" checksum="6186BB68C8C31ADF" modified="2006-03-21" version="1">MPRPKRSRVPATRPNKVASPSPEGPQSSGTPPIVTKPIAAQPEVPGSDIYGVSDREKERMKERSAKAATAGSQSRRTRASQHLDVNSDQARALEDSKRRRDDAMNRLDDLTSTSRPDESESPGTGQGREIAGERQPRLTDLSGLDLDDELFANLDDSLDDTENAIEETRTGYRSTDTSTFNVAMFKRRPRQSSVAGRGDGPIRPSSRRQNTPSISGALNFGDFRRRAREQSILGTDRKARTARSLSRTSQASRNASVLGDGDDSASLLPRRRHKASTRDNDNNDPFDLDASEDERYNANGNDANEASYVDSRPTRRRKAQRPLAKSTSNGKGKQAETRNAGGKRRAVRTYGSTNDDKENDEVADEFVVGSGNEELDEEAQEELPVEETSQMMVERLGEELQKAAKKFKEVDKWELSFEQATQSSSPGPFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H986</accession>
    <name>Q2H986_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229734.1">
        <property type="nucleotide sequence ID" value="XM_001229733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H986"/>
    <dbReference type="STRING" id="306901.Q2H986"/>
    <dbReference type="GeneID" id="4389481"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03218"/>
    <dbReference type="eggNOG" id="ENOG502S6ST">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030774_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H986"/>
    <dbReference type="OMA" id="YSQTMPI"/>
    <dbReference type="OrthoDB" id="5431149at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="479" mass="50934" checksum="F76926895B9C3F46" modified="2006-03-21" version="1">MAIPRTVPAALGAVAFFPTTAILGIHIILARSPADRASSVRTTGIVAALFEAVIFVAVPFLSLSHVVPWAPSSHWKWFRRVWFDAGLALCTVATVISISNIVCLSKVVHDPLSTILGWGVGDFLVGASVALGLAFATQLVFFIFHFLAGRALGSRPEGSAQTELGNKLGPRIKTVPYHETTPTSAKDRGSASFDSPTPPGSSGDRSGMETINSARSSLSHAIRPITSKTRLLSLSRRSSHRPTSLDLPAAQDRQSRSTEVGFDSWDTSAVDPETRQTVLESSSPPHSRFLETIPASPTTSRSPSPGTALDILEPPRAKRRSRSYSPVSTRAIQAQRVAFTQQESNSEAHIHPLFRSDSPAPPSATPGTVVVAAPNAGQVISDKHSIRSIQSIRRLRSESLPPVPGPSPLSRAGSCESFARRRADSSSPELREEDEVEAVVVGAAAAAAAVDTERKMTPPIPDYILNAGSTSSLTTSQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9S8</accession>
    <name>Q2H9S8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Misato Segment II tubulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229542.1">
        <property type="nucleotide sequence ID" value="XM_001229541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9S8"/>
    <dbReference type="STRING" id="306901.Q2H9S8"/>
    <dbReference type="GeneID" id="4388539"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03026"/>
    <dbReference type="eggNOG" id="KOG2530">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_909121_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9S8"/>
    <dbReference type="OrthoDB" id="271881at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049942">
        <property type="entry name" value="DML1/Misato"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019605">
        <property type="entry name" value="Misato_II_tubulin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION REGULATOR MISATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391:SF0">
        <property type="entry name" value="PROTEIN MISATO HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10644">
        <property type="entry name" value="Misat_Tub_SegII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Misato Segment II tubulin-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="306" mass="34800" checksum="14EDC39CF8D19365" modified="2006-03-21" version="1">MTRWWESYFTYSPDQPESPIDHDIHFRPGLAPDGTETYMPRTVFYDLKNAFGTLRKVNALYDIERRHPRRPSTMLDPTSLWHTSALLAAAVESVMLPSRMKDPLKRESLGQMAEVLNVMGKQSVAGLQMSFARPGSEDTREKKLSEEELSEGVQLDIRFAPSYQLDSYTRSNGFDRPRVFGQLVTSRGYEEEQGENGEEDEAGRRVRRSSYEPVTKSCTTDLRFPLLDSFPEIFRGDDDEPLTESLNITSSLSTDSSVARKLKQLRSTVIRSIGLEDRETLGNELMEMADEYHEGWSSGSDDGEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9T6</accession>
    <name>Q2H9T6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_03018</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229534.1">
        <property type="nucleotide sequence ID" value="XM_001229533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9T6"/>
    <dbReference type="GeneID" id="4388600"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03018"/>
    <dbReference type="eggNOG" id="KOG4505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008635_4_1_1"/>
    <dbReference type="InParanoid" id="Q2H9T6"/>
    <dbReference type="OMA" id="MGYYGPI"/>
    <dbReference type="OrthoDB" id="5327978at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF3">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="6">
        <location>
            <begin position="13"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="6">
        <location>
            <begin position="258"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ91083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="501" mass="54634" checksum="9CEA05C1B54F197B" modified="2006-03-21" version="1">MPNLDVSELNIVLSVLVPAVVIGVVLGPIAAKFLDSSRWASAADGQTSAITLGMARVVIGVQLVIAGFQLPAKYQQLRWKEMALCLLPIMTVMWLCTTLCLLATVPRITLLAALVIGSCVTCTDPILSQAIAKGPFAGQVRRPPPARDHLVRGRRQTTAFGFPIPSMLAVYLIRHADIPGAGAAHGEEAGLVARAGDVGRLGGGVGVAMQNWFVETWLYIVLMSVAIGALVGGVSMFALRFALRKKWVDSESYLLYPTAIGVSIPISYMDSTEDRHDEVNSCMDVLLNFGGFMYIGTIIPWSEFNQPDTTGLTYGRLIGLGVLVLLFRRIPAILMSYKFMPAVCKNYKEALFMGYFGPIGIGAVFYVEHARHLFPELGEGDAEETDLVRAMVPVVYWLVLFSIVVHGLSIPALNLIYRLCGVKPIQEDAVELRRMSTRVVTPVNATVGDSDTFIAYNRFSRPVFNKADLPPVNGVGAGDDDSIAEEKTRVQRRYSRRVQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAK5</accession>
    <name>Q2HAK5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229265.1">
        <property type="nucleotide sequence ID" value="XM_001229264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAK5"/>
    <dbReference type="GeneID" id="4389012"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02749"/>
    <dbReference type="eggNOG" id="ENOG502TDNE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_836785_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HAK5"/>
    <dbReference type="OMA" id="IMERSTF"/>
    <dbReference type="OrthoDB" id="4577969at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="332" mass="37502" checksum="BEBCBBE1EEFCC746" modified="2006-03-21" version="1">MNLSASIDNPAVDGGNWRYIISGMGMSIWPLRLSTQDRSRRSPRRALKMKAKLSTGRIERPPQKTRVSGNRYDEAFTAIVAAAMFSYVPFRQPLAALDGRFAKYILLPARQSEMDDEMVQLGGQPSFPIESRLPSDREDPCLFRTRLIDRMTDSEADITFGSTDMVNCDDVNFDDTQCISVGRSTRKSRAMPGAPTPPMHHHTAQVSEDHDDQNNTDNTSQMETINMPFWNLPRPPKRPILRAGDTIPDDMSIISDASLIPTYYPSDIMKQKQQSSQRFQHRTLFKQILRAKARVAKQTVRKLKRSCRDVVGHVFVESAHRGPKCVAVGSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAL6</accession>
    <name>Q2HAL6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase Rpb4/RPC9 core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_02738</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229254.1">
        <property type="nucleotide sequence ID" value="XM_001229253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAL6"/>
    <dbReference type="STRING" id="306901.Q2HAL6"/>
    <dbReference type="GeneID" id="4389211"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02738"/>
    <dbReference type="eggNOG" id="KOG2351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110332_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HAL6"/>
    <dbReference type="OMA" id="HRKTQNE"/>
    <dbReference type="OrthoDB" id="2186918at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030880">
        <property type="term" value="C:RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.40:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="5">
        <location>
            <begin position="29"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ90803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="146" mass="16381" checksum="C388DF613FD8E32E" modified="2006-03-21" version="1">MSDQNHAPTSRSKPPPPGEEEAGAVLKLGEFEGVDTLTLSEASLVIDALMLKRRKDRKDRNETDVLNKTLDYLDAFARFKEKENVEAVERLLSSHKELTKFERAHIGSLCCDSADECKTMIPSLADKISDERLQELLDEMAKLMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAQ8</accession>
    <name>Q2HAQ8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_02696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229212.1">
        <property type="nucleotide sequence ID" value="XM_001229211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAQ8"/>
    <dbReference type="GeneID" id="4389557"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02696"/>
    <dbReference type="eggNOG" id="ENOG502T5AH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_665646_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HAQ8"/>
    <dbReference type="OMA" id="ANWLRTT"/>
    <dbReference type="OrthoDB" id="4775210at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929:SF3">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="134"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ90761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="413" mass="45556" checksum="6D1DFA1BD087021B" modified="2006-03-21" version="1">MEVGQLINLADDDVDGPRDGQIPDCEAQVDGARASEPASHPVRSWQENEDIANLTANLFNDNDDLHYVSSRYYSTDDLSQPPTEASATEAIATPSPSTRKRPRQKSLAIRPTQNKRKKTAPKKEDCKLVFSREITTRVMQLFLDETRAGALKDTKASFQKPAMERILKAMEAEFPRFTWAVDKVRAKYKNERRRYRMLLTLLAISGVNFSHETGLPSAPDNVWKSFLKKYPKANWLRTTSIGDRDVYAEVYHNEKASGRHIKEARQLVGPGRVLDDPDIDVDDFSAVEDSSGDTDTDDPDDNTDDEDNIEAVAAPRTPVPRGAARPRRSREPGVMAVADSIGRLAESNTTSTTRVVTELAGADDIRMALKDFQEGFAGSLDGDEISTVPRANPAIAAIALTKTTPSSPSPLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAZ7</accession>
    <name>Q2HAZ7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein O-GlcNAc transferase</fullName>
            <ecNumber evidence="3">2.4.1.255</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_02607</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="3"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229123.1">
        <property type="nucleotide sequence ID" value="XM_001229122.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HAZ7"/>
    <dbReference type="GeneID" id="4389936"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02607"/>
    <dbReference type="eggNOG" id="KOG4626">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001721_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HAZ7"/>
    <dbReference type="OMA" id="GFRDRWH"/>
    <dbReference type="OrthoDB" id="421121at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000552">
        <property type="entry name" value="UDP-N-acetylglucosaminyltransferase (AFU_orthologue AFUA_1G03380)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11380:FF:000004">
        <property type="entry name" value="UDP-N-acetylglucosaminyltransferase (AFU_orthologue AFUA_1G03380)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000110">
        <property type="entry name" value="UDP-N-acetylglucosaminyltransferase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029489">
        <property type="entry name" value="OGT/SEC/SPY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13844">
        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 8" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="366"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="778"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="10">
        <location>
            <begin position="1048"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="10">
        <location>
            <begin position="1208"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="451"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ90672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1434" mass="157456" checksum="DF8E942C04DB2E57" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HB69</accession>
    <name>Q2HB69_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_02535</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229051.1">
        <property type="nucleotide sequence ID" value="XM_001229050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HB69"/>
    <dbReference type="STRING" id="306901.Q2HB69"/>
    <dbReference type="GeneID" id="4388615"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02535"/>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038617_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HB69"/>
    <dbReference type="OMA" id="FINEHAG"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00238">
        <property type="entry name" value="ERp29c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02998">
        <property type="entry name" value="PDI_a_ERp38"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000032">
        <property type="entry name" value="Protein disulfide-isomerase A6 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF11">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07749">
        <property type="entry name" value="ERp29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47933">
        <property type="entry name" value="ERP29 C domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209157" description="protein disulfide-isomerase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="8"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="135"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ90600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="373" mass="39839" checksum="EF504D8F61AD1F3A" modified="2006-03-21" version="1">MVLIKSFVLASLAAAAAAKSAVLDLIPDNFDNVVLKSGKPTLVEFFAPWCGHCKTLAPVYEELALAFEHGKDKVQIAKVDADAEKALGKRFGVQGFPTLKFFDGKSDKPTDYNGGRDLESLSAFITEKTGVRSKKKAAKPSSVTMLTDSNFKEQIGGDKNVLVAFTAPWCGHCKSLAPTWETIAENFATESNVLIAKVDADAETGKRTAAEYGVTGYPTIKFFPAGSTTPEDYNGGRSEEALVAFLNGKAGTHRAVGGGVDSTAGTVEALDAIVAKLVGGTTLAEAAAEAKKTAEELKDQVQAKWAEYYLRVFEKLSKAEGYVTKELARLEGIIKKGGLAPTKQDELASKANVLRKFAEKATGGEKKEEKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBF3</accession>
    <name>Q2HBF3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">alkaline phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_02451</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="1"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228967.1">
        <property type="nucleotide sequence ID" value="XM_001228966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBF3"/>
    <dbReference type="STRING" id="306901.Q2HBF3"/>
    <dbReference type="GeneID" id="4388966"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02451"/>
    <dbReference type="eggNOG" id="KOG4126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008539_3_0_1"/>
    <dbReference type="InParanoid" id="Q2HBF3"/>
    <dbReference type="OMA" id="GSADTEY"/>
    <dbReference type="OrthoDB" id="5818554at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF72">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209384" description="alkaline phosphatase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="2">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="612"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ90516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="666" mass="72329" checksum="E3BC50F9521FC665" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBQ1</accession>
    <name>Q2HBQ1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_02353</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228869.1">
        <property type="nucleotide sequence ID" value="XM_001228868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBQ1"/>
    <dbReference type="STRING" id="306901.Q2HBQ1"/>
    <dbReference type="GeneID" id="4389054"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02353"/>
    <dbReference type="eggNOG" id="ENOG502SXC3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_809374_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HBQ1"/>
    <dbReference type="OMA" id="GRAMGCD"/>
    <dbReference type="OrthoDB" id="4866377at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208736" description="Extracellular membrane protein CFEM domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ90418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="38056" checksum="6B9317880D3BA53C" modified="2006-03-21" version="1">MASRAGLLSRLLCLLLLYPQALLAVGTGTVSKFGDDWPHDCVQYCLGRWPNVYDNMGSALQCGKPFYNECYCATAAASASLATSFLASCASTSCAGGDVTLDLSAMQSIYASYCMENGFTQPGATAWYSPAAETGAPAPGNTGETDSAPLTTTRVSVVTQMTAPDSGGSSSTQSWVTVDATSTVWVNAAGSSVPAPSSDNNQTTLKLGLGLGLGLGIPLALAIAGLTVWLYIRNRRPPNPNDQPLPPSLAADIEPAGPSPSPLPRKPVAAAAAATTNPAPPPLSSTPATATRELEGGRGIHRELGGTGVHPFPDVGPSPPVLVPGQHELHGVGRQPELPGLSGSPPPQYYYYQGAAGPGIQGGRERWEMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBQ9</accession>
    <name>Q2HBQ9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_02345</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cell membrane</location>
            <topology evidence="1 5">Lipid-anchor</topology>
            <topology evidence="1 5">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228861.1">
        <property type="nucleotide sequence ID" value="XM_001228860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBQ9"/>
    <dbReference type="GeneID" id="4388364"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02345"/>
    <dbReference type="eggNOG" id="ENOG502SHAA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS2"/>
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    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005142962" description="1,3-beta-glucanosyltransferase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="396"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ90410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="576" mass="60789" checksum="31896A65E58B2065" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCG1</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001221313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCG1"/>
    <dbReference type="STRING" id="306901.Q2HCG1"/>
    <dbReference type="GeneID" id="4388117"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02093"/>
    <dbReference type="eggNOG" id="KOG1558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027089_1_2_1"/>
    <dbReference type="InParanoid" id="Q2HCG1"/>
    <dbReference type="OMA" id="VGFMNAV"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF60">
        <property type="entry name" value="FAMILY ZINC TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
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        <location>
            <begin position="157"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ93858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="442" mass="47743" checksum="310095118594B6A8" modified="2006-03-21" version="1">MEKLGLRADDPRWSSIPTDLLLAELARRDDANERPACGSGKKGSYDTGIHVFALFLILALSTLSCGFPLFSQRLSKGSKRQRNIIFLCQHFGTGVLMATAFVHLLPTAFTSLTDPCLPHAFSKGYRPLAGLIAMVSAFVVVALESYLTTRGASHSHSHHAWEEVDSDDGDENVGGRTQEGEFSSRHARRDRPSSIALDDLEATEGLVAGASPLPGSTPTMAPPREGLLKPQRDSTQDDNRESLDLELSFEELSPSPNPDHQPKPEPELPPLQHIPTPEEQKRMMLQCVLLEAGILFHSVFIGMALSVATGPTFAVFLIAISFHQSFEGLALGTRIAALHFPRSSPRPWLMVLAFGATTPIGQAIGLFIHRFYDPMSQAGLLMVGFMNAISSGLLLFAGLVQLLAEDFLSEKSYGVLKGRRRVSAFLAVVGGAGLMAAVGAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCX6</accession>
    <name>Q2HCX6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221149.1">
        <property type="nucleotide sequence ID" value="XM_001221148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCX6"/>
    <dbReference type="STRING" id="306901.Q2HCX6"/>
    <dbReference type="GeneID" id="4386478"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01928"/>
    <dbReference type="eggNOG" id="KOG1211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_0_2_1"/>
    <dbReference type="InParanoid" id="Q2HCX6"/>
    <dbReference type="OMA" id="YGMSDTN"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF67">
        <property type="entry name" value="AMIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="153"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="690" mass="74195" checksum="62B3B3CE4353A20D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HD33</accession>
    <name>Q2HD33_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_01871</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221092.1">
        <property type="nucleotide sequence ID" value="XM_001221091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HD33"/>
    <dbReference type="FunCoup" id="Q2HD33">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HD33"/>
    <dbReference type="GeneID" id="4386419"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01871"/>
    <dbReference type="eggNOG" id="KOG3873">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034001_0_0_1"/>
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    </dbReference>
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            <end position="452"/>
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        <location>
            <begin position="501"/>
            <end position="526"/>
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            <begin position="11"/>
            <end position="323"/>
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            <end position="574"/>
        </location>
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            <end position="343"/>
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            <begin position="372"/>
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            <begin position="554"/>
            <end position="567"/>
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        </source>
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        </source>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ93636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="574" mass="62468" checksum="D2CA5BDCC2EB51B6" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDD3</accession>
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        <recommendedName>
            <fullName evidence="8">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">CHGG_01771</name>
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        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR019318">
        <property type="entry name" value="Gua_nucleotide_exch_fac_Ric8"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ric8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="8">
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        </location>
    </feature>
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            <end position="321"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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    </feature>
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    </feature>
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        <location>
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        <location>
            <begin position="543"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
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            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="692"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ93536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="706" mass="76336" checksum="78DD9F05A0569107" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HE70</accession>
    <name>Q2HE70_CHAGB</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">CHGG_01484</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220705.1">
        <property type="nucleotide sequence ID" value="XM_001220704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HE70"/>
    <dbReference type="GeneID" id="4387462"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01484"/>
    <dbReference type="eggNOG" id="ENOG502SFMK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096545_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HE70"/>
    <dbReference type="OMA" id="CCIAGCF"/>
    <dbReference type="OrthoDB" id="5597238at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208837" evidence="3">
        <location>
            <begin position="19"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ93249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="201" mass="19697" checksum="1681BA0449F43D8B" modified="2006-03-21" version="1">MRVTSIFLAAGLALFANAQTTTGGDSASKTVDAATAAQTSAQAEMLRCLNACDADDVNCRAKCIAVPSPNDQQANATNTCVAGCPVGKGTEADNNAYAKCVGDCIGQNYYTPTIGTPQPTGGSNSGNGNNGNGNGNNNNGNGNSDGDNNGNNDDATNTGDSEGSQTSDSPSTTESTGAAALLGVSSGVVGAVGFVAAIMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HE78</accession>
    <name>Q2HE78_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_01476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220697.1">
        <property type="nucleotide sequence ID" value="XM_001220696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HE78"/>
    <dbReference type="GeneID" id="4388206"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01476"/>
    <dbReference type="HOGENOM" id="CLU_2061224_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HE78"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ93241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="119" mass="13088" checksum="5E2A0996438D8624" modified="2006-03-21" version="1">MYQIGCTGAEDKRPIQRFNIIFVDRRVGMNDSHDSQLATAKAAERTRGQNSTLGYVVQAVLGLRVGWRKKLSGSLSCMLEGFRLTEIPGPSTNPDLVSSNVERRASAMQGRTCRAARAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEE3</accession>
    <name>Q2HEE3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_01411</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220632.1">
        <property type="nucleotide sequence ID" value="XM_001220631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEE3"/>
    <dbReference type="STRING" id="306901.Q2HEE3"/>
    <dbReference type="GeneID" id="4387419"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01411"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_888528_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HEE3"/>
    <dbReference type="OMA" id="HIATKSC"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="246"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ93176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="313" mass="32186" checksum="0907F0EC58B7D511" modified="2006-03-21" version="1">MKKKVKVRTTRGGHVEAEDWTEDLEDVFQAAAKGNVKSLRAHLSRGVSPAIKEQVLFGYNLLHLAVLSGNLAAVQLILQYKPNLNATADDGQTTALVLACGDNATNQGPNPAIVRLLLNSGAHVSTLSSPGTYPLHAAAASSTTDATVRLLLAAGASITALDAAERQTALHKAAYGRSAAVMRALLAAPGAGGIVNVPDAEGMRPLHLAVDIPDDYDDDVAYVARRAELAGLLLAAGADPNVLGGEGNAPLHVAIACRAGAVVRCLLEGGADPNLRDGDGWTPLMGAEYVKDRGIVALLERYGGVKGSDAGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFE9</accession>
    <name>Q2HFE9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_01055</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220276.1">
        <property type="nucleotide sequence ID" value="XM_001220275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFE9"/>
    <dbReference type="FunCoup" id="Q2HFE9">
        <property type="interactions" value="750"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HFE9"/>
    <dbReference type="GeneID" id="4386793"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01055"/>
    <dbReference type="eggNOG" id="KOG0761">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_0_5_1"/>
    <dbReference type="InParanoid" id="Q2HFE9"/>
    <dbReference type="OrthoDB" id="1747031at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045315">
        <property type="entry name" value="Mtm1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760:SF2">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="30"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ92820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="22575" checksum="517689CB5C6EB5BE" modified="2006-03-21" version="1">MAIPANIIYFTGYEWLRFNRAGSPIARAVPDDYAPLVAGSAARILAATVVSPIELFRTRLQAVPERAATNPLTSTFRGIQDMVAAHGYRSLWRGLSLTLWRDTRTQVFRDTTTSTSTTTTASATASAAAPEERNMARLLWHIFRTEGLPGLFRGGVPRTLRVAPACAIMISSYEVGKRVFRGVNERALAERRGLVQGGGGGATAVGGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFK9</accession>
    <name>Q2HFK9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_00995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220216.1">
        <property type="nucleotide sequence ID" value="XM_001220215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFK9"/>
    <dbReference type="GeneID" id="4386575"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00995"/>
    <dbReference type="eggNOG" id="ENOG502SF4J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035048_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HFK9"/>
    <dbReference type="OMA" id="VSCRRIA"/>
    <dbReference type="OrthoDB" id="5338512at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209143" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ92760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="46892" checksum="C82D6E5E134E461F" modified="2006-03-21" version="1">MPRRHLALWAAVLAAVHAAASAVPIHELFARQSSCARNFDQCKNADFPDYFCCKTGETCIALAGNTTVLCCPEGADCLRIQPVPCDIALQDGEKNPDAVVKTTALGGTLARCGTQCCPFGYSCRDGQCARDQNQNAVPFQTKTVKPGPTSTGGAKTSATGGASPTADTTDSAGDSNATADSSNNTGDSSSGPPVAAIAGGATAAAVVVIGAAVFAFIFFRKKQKKEEAAGSGSPPKLSRSTSSFGNLISNPIMADNSFRSDFARNPGPRTPPQYPEDPDSVTGALIASAANTPEAGGMQAGGMQAGGMQTAGMLAVPAAAAPGPAAQIAPVYGGYGNLEQPQYVDMPYVNHDNGLLPQTPRQHREPSSVSINVFADPNITPDRTPESNVQPAVHRRDHSFSQMLDNADLGDMAERSGYLGYNPNRWAGSTDARGGDVMVLGRVQRGLETRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFN0</accession>
    <name>Q2HFN0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial protein import protein MAS5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_00974</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220195.1">
        <property type="nucleotide sequence ID" value="XM_001220194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFN0"/>
    <dbReference type="FunCoup" id="Q2HFN0">
        <property type="interactions" value="1061"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HFN0"/>
    <dbReference type="GeneID" id="4386817"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00974"/>
    <dbReference type="eggNOG" id="KOG0712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_10_2_1"/>
    <dbReference type="InParanoid" id="Q2HFN0"/>
    <dbReference type="OMA" id="RVCPTCV"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140453">
        <property type="term" value="C:protein aggregate center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140455">
        <property type="term" value="P:cytoplasm protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140454">
        <property type="term" value="P:protein aggregate center assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035719">
        <property type="term" value="P:tRNA import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000048">
        <property type="entry name" value="DnaJ family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="137"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="137"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="368"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ92739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="45162" checksum="40808AAD2A381525" modified="2006-03-21" version="1">MVKETGYYDVLGVSPNATEQELKKAYKTGALKYHPDKNHNNPAAEQKFKEISHAYEILSDSQKRQVYDQFGEAGLEGGAGGGGGMAAEDLFAQFFGGGGGLGGFGGMFGGMNSQRGPSKAKTIHHVHNVSLEDIYRGKVSKLALQRSIICPKCEGRGGKEGAVRKCAGCDGHGMKTMMRQMGPMIQRFQTVCPDCSGEGEIVKDKDRCKQCFGKKTVVDRKVLHVHVDRGVRSGTKVEFRGEGDQAPGILAGDVVFQIEQKPHPRFTRREDDLVYQAEIDLVTALAGGTIYVEHLDDRWLSVDILPGEAIAPGTVKMIRGQGMPAPRHHDFGNLFIQFAVKFPEKNWTQDPAAFDALRKFLPSPDLVNTPPAEAMSEPADLEDVDSSSRGFSGAMEEDDEHEHHGGERVQCASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFP3</accession>
    <name>Q2HFP3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220182.1">
        <property type="nucleotide sequence ID" value="XM_001220181.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HFP3"/>
    <dbReference type="GeneID" id="4387324"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00961"/>
    <dbReference type="eggNOG" id="ENOG502QTS5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_240123_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HFP3"/>
    <dbReference type="OMA" id="WLANTHQ"/>
    <dbReference type="OrthoDB" id="3925024at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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</entry>
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                <person name="Untereiner W.A."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
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                <person name="Untereiner W.A."/>
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            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="HOGENOM" id="CLU_3299307_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGM8"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="40" mass="4599" checksum="9343FDC6D414FC4E" modified="2006-03-21" version="1">MHHEWTAKGAEPEMNKNRYPGKSGLILEGWQDFATPTSWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHM8</accession>
    <name>Q2HHM8_CHAGB</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219497.1">
        <property type="nucleotide sequence ID" value="XM_001219496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHM8"/>
    <dbReference type="STRING" id="306901.Q2HHM8"/>
    <dbReference type="GeneID" id="4387334"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00276"/>
    <dbReference type="eggNOG" id="ENOG502RYDN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061199_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HHM8"/>
    <dbReference type="OMA" id="YPVIRAN"/>
    <dbReference type="OrthoDB" id="408152at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="228" mass="26148" checksum="7DFFF613F44FB46C" modified="2006-03-21" version="1">MASPNTFPNTPSSSSGNTPTNLKIINASLFRMGTKADWDALWGGYDVVTDLASPFAVELVQAYPEAKVVVVQRAFEKWWPSFRDEVLDRVMVQPMATVNGWIGWHVMGIRAVQAMRKVHFGLFGAKTRPEIEENARRTYEEYFKKIRRLVPEERRLEYKMGDGWEPLCEFLGVPVPDVPFPRANEQEAHQEEVKKRLGKFYGSTLRLVLPGVVGSITVLVGWWWYQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI50</accession>
    <name>Q2HI50_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_00104</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219325.1">
        <property type="nucleotide sequence ID" value="XM_001219324.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HI50"/>
    <dbReference type="GeneID" id="4387904"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00104"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_246877_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HI50"/>
    <dbReference type="OMA" id="VFLAHSM"/>
    <dbReference type="OrthoDB" id="427518at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="134"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="689"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="723"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="985"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1016"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1083"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1116"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1149"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1254"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1340"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1484"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1254"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1342"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1379"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1391"/>
            <end position="1401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ91869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1539" mass="164375" checksum="231815480047BE41" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HIA4</accession>
    <name>Q2HIA4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_00050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219271.1">
        <property type="nucleotide sequence ID" value="XM_001219270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HIA4"/>
    <dbReference type="STRING" id="306901.Q2HIA4"/>
    <dbReference type="GeneID" id="4386569"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00050"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024200_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HIA4"/>
    <dbReference type="OMA" id="KSATYVW"/>
    <dbReference type="OrthoDB" id="9876900at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050501">
        <property type="term" value="F:hyaluronan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085029">
        <property type="term" value="P:extracellular matrix assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030213">
        <property type="term" value="P:hyaluronan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913">
        <property type="entry name" value="HYALURONAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913:SF12">
        <property type="entry name" value="MANNURONAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="573"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ91815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="595" mass="66184" checksum="21A13106884088A5" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HIC0</accession>
    <name>Q2HIC0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219255.1">
        <property type="nucleotide sequence ID" value="XM_001219254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HIC0"/>
    <dbReference type="GeneID" id="4387672"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00034"/>
    <dbReference type="HOGENOM" id="CLU_1175271_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HIC0"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="236" mass="26269" checksum="383CD887996FAD1E" modified="2006-03-21" version="1">MISTEFGERRLSSWASLTARCKSAQAASTYFRRECPWFGCMNEMLSGPSWSADFDCFAPDAPGRQPYRCGIAHTTPSKKDRLLVEEYEGLLSIELSASNTWSRLHTEYGGEPSAYGGTPRGDDEYMYSIIHDSNPAARQAQMIAIAEDVLARLEEKATQYLIFEQTYVLKDQITQAAKAVGQLKGITGEAVSPCFRRLGRHLCRHPAADKPKYRGPTFKSSEKTSLMPSASTWAMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM43</accession>
    <name>Q2GM43_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4419 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226228.1">
        <property type="nucleotide sequence ID" value="XM_001226227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GM43"/>
    <dbReference type="GeneID" id="4397205"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10961"/>
    <dbReference type="eggNOG" id="ENOG502SKQ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037155_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GM43"/>
    <dbReference type="OMA" id="IVPELRW"/>
    <dbReference type="OrthoDB" id="9978173at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025533">
        <property type="entry name" value="DUF4419"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252:SF11">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14388">
        <property type="entry name" value="DUF4419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="46784" checksum="585801DABCA6AE1C" modified="2006-03-21" version="1">MPVIIKPDPDSPSGTNRDPVTSSPFSLLSKASPTHKLYPILRSSFRDRHSTRPPSSIAPDKNGFAHTVIRAWQQDLHLKLRPDDVWLAILTQFSFFVNGNAEALRPIFVTHEGQEELLVHVEGTIGSVDYGVIAQKLAAMAKERLVDPNIATTLLPNFTTTTPDDRAVASMVFMGVVNEYFAYRVRFGCGFPSVTLLGEPGDWADMLERVAWFGTLGHEETNAWTIRLTKVLEYMVASFDSPDDANIKDFWACAVHEAKSGMSGGIVTLSGWLSAFCWWDGSGERMRSYTDEELARKHLTGYRRLTLDDVEFPVIERKEVPPGVVAVPITLCQAEPTKAVLVAGSMGMQVTKEGEGQTVAQPASGWWLLADRGETFGRPRRTKEEIEAEKEKKRRWDDMTPIMVQPHPGGVKAWRRSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM90</accession>
    <name>Q2GM90_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226181.1">
        <property type="nucleotide sequence ID" value="XM_001226180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GM90"/>
    <dbReference type="STRING" id="306901.Q2GM90"/>
    <dbReference type="GeneID" id="4397294"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10914"/>
    <dbReference type="eggNOG" id="ENOG502SPPP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043171_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GM90"/>
    <dbReference type="OMA" id="ENTTHMG"/>
    <dbReference type="OrthoDB" id="4590781at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="215" mass="24186" checksum="92EF91125D4B36D1" modified="2006-03-21" version="1">MKAAARELRQLLPSLARQLESFECLCCILVDAIDEHREVKTLLQIPEAVFARVEKNLKTSLSAARCVKEKLRSRLRMVDTCLSTLSAISSSKNDRAVSENTTHMGRLAEYGREENLNMGKIARATKLDSQAMKIIAIMTMLYLPATFVATLFSMGIFHFDFDNGMTGDFSVARYWWLYFTVAIPLSGATFMIFYHRVKSHKSADKKESQKAATGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMB2</accession>
    <name>Q2GMB2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226159.1">
        <property type="nucleotide sequence ID" value="XM_001226158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMB2"/>
    <dbReference type="GeneID" id="4397210"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10892"/>
    <dbReference type="HOGENOM" id="CLU_2812127_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GMB2"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="67" mass="7701" checksum="6140216228315027" modified="2006-03-21" version="1">MTPEQHQRHSHHRPVPASPTCPVSPRSFRFWTNARQKSLLAGDNKASRNLSSSYADIYHYPHTIPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMP9</accession>
    <name>Q2GMP9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_10755</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ82937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226022.1">
        <property type="nucleotide sequence ID" value="XM_001226021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMP9"/>
    <dbReference type="GeneID" id="4397171"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10755"/>
    <dbReference type="eggNOG" id="ENOG502RZS9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029790_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GMP9"/>
    <dbReference type="OMA" id="MTDGHSA"/>
    <dbReference type="OrthoDB" id="1368at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ82937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="511" mass="55956" checksum="B370AD961BD5262B" modified="2006-03-21" version="1">MAEDGHAAGGAPTAHAAPGAPGAGGHGPADNLAINTQIKTNGSGPNGVALEEIASLTSPRLFTPNPFSRKNTSLDIDDYFTGPRDIQKHSKWPIFLQMHGSILPKLILPLLSIGAWATCVTCIHVLVTPINIGSVLLTVLGFVVGLGLSFRSSTAYERYAEGRRYWAQLILASQNLGRVFWVHTAERSDIPEDQQEQHKRRDVLERLTAMNLVVAFSVALKHRLRFEPYTCYDDIANLVSHLGTFAQAATTDDPDNAQRAFKRHGFFKSVGEYLGVSFAESNPRKAVKKAGRPLGNLPLEILSYLASYADELSLDGRLPIPMQQTTVYNNIAVLNDVLVGTERVLNTPLPIAYAIAIAQITWVYILVLPFQLLGTVGDQTWITIPATVVAAYIILGILFIGREIENPFGQDVNDLPLEVYCAQIAAEMDVIAARPKPRSRDWMESIDNRVLWPLSSSGWPVWMKRSEDKIREAVVHKVEATFVSQKGKEAAVLKGRAPSEKGYAKGSVSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMT5</accession>
    <name>Q2GMT5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228646.1">
        <property type="nucleotide sequence ID" value="XM_001228645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMT5"/>
    <dbReference type="STRING" id="306901.Q2GMT5"/>
    <dbReference type="GeneID" id="4397072"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10719"/>
    <dbReference type="eggNOG" id="ENOG502RFU7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_461502_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GMT5"/>
    <dbReference type="OrthoDB" id="3431997at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208394" description="FHA domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="64342" checksum="B173AE6213201E6D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN23</accession>
    <name>Q2GN23_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-carboxy-cis,cis-mucoante lactonizing enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228558.1">
        <property type="nucleotide sequence ID" value="XM_001228557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN23"/>
    <dbReference type="GeneID" id="4396427"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10631"/>
    <dbReference type="eggNOG" id="ENOG502SIAZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045869_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GN23"/>
    <dbReference type="OMA" id="CCANVVW"/>
    <dbReference type="OrthoDB" id="1715191at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF4">
        <property type="entry name" value="CYCLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="Nitrous oxide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="36789" checksum="7B9352BB239BBEB3" modified="2006-03-21" version="1">MAESAQTKAADEEAVGTCPKKERNWYYVSSTISSGNQETARAPDACFNTTSGFVTAMPNPPYHVFTGSWPSPSACGMSLSTSDTGALTKILSTWTYTNESGIHGLALSPRTAPSNTNATTTTPQPQPQLLYSADLNGDLLWTHTINLTTGAATEVARFRMPGAAGAHPRHLAAHPNGLRLYAVMEADNTVAEYVLDAATGAVTKEVVRHSLLPIEADTERYWSAEVMLSASGRYLWASARAKEEVDTGFVAVFLVGADGGIVKKMFRVPTTTRGGKANAVSPAFWDDEYAAMTDYGEGYVLMWRMEGRRERADGLVEYSTARAVAKVDVKDGGCCANAIWYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN51</accession>
    <name>Q2GN51_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228530.1">
        <property type="nucleotide sequence ID" value="XM_001228529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN51"/>
    <dbReference type="GeneID" id="4396158"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10603"/>
    <dbReference type="HOGENOM" id="CLU_3242088_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GN51"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="43" mass="4839" checksum="81953A0C95459D48" modified="2006-03-21" version="1">MPSNTKHITARVSIDKSIPVGDLAAPLRREFEDSSMKQCHNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN95</accession>
    <name>Q2GN95_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11 12">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4 11 12">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_10559</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11 12">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4 11 12"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228486.1">
        <property type="nucleotide sequence ID" value="XM_001228485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN95"/>
    <dbReference type="SMR" id="Q2GN95"/>
    <dbReference type="GeneID" id="4395938"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10559"/>
    <dbReference type="eggNOG" id="ENOG502RXA7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052631_3_1_1"/>
    <dbReference type="InParanoid" id="Q2GN95"/>
    <dbReference type="OMA" id="ISLYGWT"/>
    <dbReference type="OrthoDB" id="2115822at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.180:FF:000001">
        <property type="entry name" value="Endo-1,4-beta-xylanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018208">
        <property type="entry name" value="GH11_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033119">
        <property type="entry name" value="GH11_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF2">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00776">
        <property type="entry name" value="GH11_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00777">
        <property type="entry name" value="GH11_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11 12" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208407" description="Endo-1,4-beta-xylanase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="14">
        <location>
            <begin position="26"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ84155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="219" mass="24327" checksum="1D799CBB5FA5ECC9" modified="2006-03-21" version="1">MVSFTLLLTALAASVATASPLEALKRGIQPGTGTHDGYFYSFWTDGRGSVDYNNGPRGSYSVSWNNVNNWVGGKGWNPGPPRKVAYNGTWNNYNVNSYLALYGWTTNPLVEYYIVEAYGTYNPSSGTSRLGTIEDDGGTYDIYKTRRVNQPSIQGTSTFDQYWSVRRQKRVGGTIDTGKHFDEWKRQGNLNLGQWNYMIMASEGYQSSGSANIEVRAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNC6</accession>
    <name>Q2GNC6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_10528</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228455.1">
        <property type="nucleotide sequence ID" value="XM_001228454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNC6"/>
    <dbReference type="GeneID" id="4396459"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10528"/>
    <dbReference type="eggNOG" id="ENOG502SH79">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071363_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNC6"/>
    <dbReference type="OrthoDB" id="5313668at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048955">
        <property type="entry name" value="Cip1-like_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21340">
        <property type="entry name" value="Polysacc_lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CBM1" evidence="4">
        <location>
            <begin position="301"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ84124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="337" mass="35798" checksum="67D38B6A4C29179C" modified="2006-03-21" version="1">MNVPVCTERIPHVRESRQRECRTSSLMFQSSPPCVRLLPSSLSPPPRCPIDFESGWDQTAWPIYAPDCNQGGKVSLDSTTAHSGKNSIRVDGAGGYCGHVFFGTNKVPSGDFYVRTYLKASKALTSSHVSFITMPDPAQGTNKHLRIGGQNSILMYNRESDDATLPDLSPQGVAASTALPTGSWQCFEYHVGSDGSIETWLNGQAIAGLTSIPGQSNPNAGQWQRSSIKPKPSAVYFGWESYGGDTNTFWYDDIVISSSRVGCSGGTNPPASTTLVTSVTPGPSSTATSLAPATSTTSSGCAAAQWSQCGGIGFNGCTTCASPYTCKFSNDYYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GND4</accession>
    <name>Q2GND4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycolipid 2-alpha-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_10520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228447.1">
        <property type="nucleotide sequence ID" value="XM_001228446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GND4"/>
    <dbReference type="GeneID" id="4396906"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10520"/>
    <dbReference type="eggNOG" id="KOG4472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_267365_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GND4"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF2">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="827"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="827"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ84116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1234" mass="139469" checksum="B8E955C7BA505928" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNQ6</accession>
    <name>Q2GNQ6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228325.1">
        <property type="nucleotide sequence ID" value="XM_001228324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNQ6"/>
    <dbReference type="STRING" id="306901.Q2GNQ6"/>
    <dbReference type="GeneID" id="4396577"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10398"/>
    <dbReference type="eggNOG" id="ENOG502RMYH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054599_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNQ6"/>
    <dbReference type="OMA" id="CWQSICE"/>
    <dbReference type="OrthoDB" id="5134445at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ83994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="38545" checksum="75FBE28137953C87" modified="2006-03-21" version="1">MSPVLNVVLFGSDDSGHKFHLQAVLKLYDRRFGERLRRYRGEHVPHTMERELAFQSFVRRGMMNRFLGRQEEDFEAEDGQNQRGKFEKTEKPISLQYDLEPDAEFEAAVWEECERNFNCETQAYERLKDLQGKLIPRMYAHVRLLSPIPNVPHDLLDSSDTARYFEVKGVILQRVAGYPLYDLPTSPQAPSDMGLWPDIVQAAVDAVHMIDRRGVLNTNCAPYNIVVDSHSHTPFIIDFASCRFKERLIQQWRDNGRMGDDDDPEIEYWEEVVTVNNEGAIGVAMAARLRQMKGLELSIRYPNSQKILEDMKRSKGIESAKDRAGTSGWKILYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNS8</accession>
    <name>Q2GNS8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_10376</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228303.1">
        <property type="nucleotide sequence ID" value="XM_001228302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNS8"/>
    <dbReference type="STRING" id="306901.Q2GNS8"/>
    <dbReference type="GeneID" id="4396726"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10376"/>
    <dbReference type="eggNOG" id="KOG3385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086133_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GNS8"/>
    <dbReference type="OMA" id="MNRMLIM"/>
    <dbReference type="OrthoDB" id="261831at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000057">
        <property type="entry name" value="SNARE complex subunit (Bet1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="103"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ83972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="193" mass="20437" checksum="5BAC3B1208A2EFC5" modified="2006-03-21" version="1">MASRFGSSSLHQRDSRSDLFKGYTGGAASRTVSASPSRQQQQPQQFGNGGVGGYGYGGYQPGGGSGGSGPGGSVGASGSSHLGVAGGGGYRPATPNRNDAVLNELESQNDQQVDGILGKVRLLKDMTVAIGDEIRDSSALAEKMNDGFDQTRLRLGRTMNRMMVMAERTGVGWRVWLAFFAAVIFLFVYVWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPD1</accession>
    <name>Q2GPD1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228100.1">
        <property type="nucleotide sequence ID" value="XM_001228099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPD1"/>
    <dbReference type="STRING" id="306901.Q2GPD1"/>
    <dbReference type="GeneID" id="4396565"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10173"/>
    <dbReference type="eggNOG" id="ENOG502RX7P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057565_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPD1"/>
    <dbReference type="OMA" id="PRIECQL"/>
    <dbReference type="OrthoDB" id="4001642at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053060">
        <property type="entry name" value="Cytokinesis_Signaling_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419">
        <property type="entry name" value="ARRESTIN FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419:SF1">
        <property type="entry name" value="RHO1 GEF LOCALIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="1">
        <location>
            <begin position="192"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="349" mass="38869" checksum="2D5708A915F8F821" modified="2006-03-21" version="1">MNAANAPATVRISGPPNSSFLVGYPGISATLPRIVGKVEIRPGAGFSAPVNVSMVRICLQRRETIHPAAENVAKRHLGTPRRETVDLVGKEVLLFRCVSGKEAESVIAMDLPFQIFIPFGRSGEETNRRIPPASIQLPSRIAETYYELVVTVQQGSSMQNRYTFPIPLQRYDTLSTFGMYNRPETRAATADHIVTLGISLPKWSYGPLDPITVYVKLSPNPDYLNKAKRVTIQKLTLTIEEEITFNPEGDEPTKKINKIAKHTQAVGTKMPETGYITNLGLVLPARDLRDPDGIIKRGKPAFPMYEVTSFSTTSTLYKVEFFLSIKVRLLRMSFLALFFSQVLGPHDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPL2</accession>
    <name>Q2GPL2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_10092</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228019.1">
        <property type="nucleotide sequence ID" value="XM_001228018.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GPL2"/>
    <dbReference type="GeneID" id="4396643"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10092"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_31_0_1"/>
    <dbReference type="InParanoid" id="Q2GPL2"/>
    <dbReference type="OMA" id="PASAYCI"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="8">
        <location>
            <begin position="7"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="9">
        <location>
            <begin position="958"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="958"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1106"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2180"/>
            <end position="2235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2286"/>
            <end position="2316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="2188"/>
            <end position="2200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2286"/>
            <end position="2296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="2297"/>
            <end position="2307"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="990"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ83688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2316" mass="254308" checksum="FA63F7B053637B30" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQQ0</accession>
    <name>Q2GQQ0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227631.1">
        <property type="nucleotide sequence ID" value="XM_001227630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQQ0"/>
    <dbReference type="STRING" id="306901.Q2GQQ0"/>
    <dbReference type="GeneID" id="4396702"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09704"/>
    <dbReference type="eggNOG" id="ENOG502R8EF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099909_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GQQ0"/>
    <dbReference type="OMA" id="QFACAGI"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="12605" checksum="AB1DF0F781999F81" modified="2006-03-21" version="1">MVHGDTRARTGLTTFLLASSALVWVSAVIVMGILAYLVSRGWGGDHIIYELVISVLTTAFFPLAFFLVISPGFILLFNLIFSYLWIVAVSFTASDWSNSHSDLLLAVEAFSFIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQQ2</accession>
    <name>Q2GQQ2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_09702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227629.1">
        <property type="nucleotide sequence ID" value="XM_001227628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQQ2"/>
    <dbReference type="GeneID" id="4396700"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09702"/>
    <dbReference type="HOGENOM" id="CLU_2263449_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQQ2"/>
    <dbReference type="OrthoDB" id="10303309at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ83298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="103" mass="11161" checksum="5F0642C69349FEE6" modified="2006-03-21" version="1">MLIQRRLHPSRFVAIRTARAKKQFYFIGNPQKQSQELLDPVSGGMLRDKLPCKVRVPRQCPCGCGSESTAGCEPSTCITPPSPEIGGVLPADLPLPPRALAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRD8</accession>
    <name>Q2GRD8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_09466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227393.1">
        <property type="nucleotide sequence ID" value="XM_001227392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRD8"/>
    <dbReference type="GeneID" id="4395685"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09466"/>
    <dbReference type="HOGENOM" id="CLU_2849504_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRD8"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ85452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="65" mass="7015" checksum="90D43250F59C0E58" modified="2006-03-21" version="1">MNLAGAMMNQARECLHALINDALHPPERRSWAQLSAGAYGGGGPIAFRRMAFRRAPPQQPGGLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GS19</accession>
    <name>Q2GS19_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_09235</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227162.1">
        <property type="nucleotide sequence ID" value="XM_001227161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GS19"/>
    <dbReference type="FunCoup" id="Q2GS19">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GS19"/>
    <dbReference type="GeneID" id="4395718"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09235"/>
    <dbReference type="eggNOG" id="KOG1418">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013394_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GS19"/>
    <dbReference type="OMA" id="TAMGEIG"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000182">
        <property type="entry name" value="Outward-rectifier potassium channel TOK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF301">
        <property type="entry name" value="POTASSIUM CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="198"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="360"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ85221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="504" mass="56823" checksum="1E0A401C36793ABE" modified="2006-03-21" version="1">MNEYSEEIQEYVPKQATKERDHLKPSRWWFASSAFPMIAGTLGPVASAFSICALVKPWRQSYPPGTDVDLATYMRDPVWLTAVNAVQLFIAIVANMALLLNMTRRLSFAIAQPVTIIGWYISSFALISLTATASGPLVVELDDEFIWSQAFYYAIYSAVLYFLVASLMVVTYLGAQAGRYPKDFVLTASQRTLMLQTIMFLMYLLLGALVFCEVESWSYLDAVFWAAVTLFTVGFGDLYATTPLGRALLIPYSLVGIISLGLVIGSIRSLVLDRGKQRLGNRMLEKKRRRTLRRMTRTGKDEVLIPIRDDPPTVVAVRTDTSELTEFERREREFNIMRKIQDVSAHRRRWFAMGVSTGTWLVLWLAGAKVFQKCEERYQGWSYFDGFYFAFVSLTTIGYGDITPVSNAGKSFWVFWSLLALPTMTVLISNAGDTIVKGIRDATDQIATVTILPGEQGYKKDLKRLLRTFSCGVLFKESAEEVPAGFLGQPRPLERSRAHSNRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GT66</accession>
    <name>Q2GT66_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_08838</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226765.1">
        <property type="nucleotide sequence ID" value="XM_001226764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GT66"/>
    <dbReference type="STRING" id="306901.Q2GT66"/>
    <dbReference type="GeneID" id="4395566"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08838"/>
    <dbReference type="eggNOG" id="KOG3328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089876_12_1_1"/>
    <dbReference type="InParanoid" id="Q2GT66"/>
    <dbReference type="OMA" id="KQIMRAM"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000033">
        <property type="entry name" value="acyl-coenzyme A thioesterase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF57">
        <property type="entry name" value="PAAI THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="4">
        <location>
            <begin position="58"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ84824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="165" mass="17890" checksum="68DBE97203DEC472" modified="2006-03-21" version="1">MATSAGTKLKPLRFVRTTTPHPKYNPQAHHTQLRISNATEGSVDFELHITKDHTNRLNIIHGGTIASLVDLGGSLAVASRGYYMTGVSTDLNVTYLSSGGKIGDKLHGTAECDWIGKTLAYTRVTFWDSQRNMVARGSHTKWGPLPLSELEPEPVPKSTSTSTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTH0</accession>
    <name>Q2GTH0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226661.1">
        <property type="nucleotide sequence ID" value="XM_001226660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTH0"/>
    <dbReference type="FunCoup" id="Q2GTH0">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GTH0"/>
    <dbReference type="GeneID" id="4395022"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08734"/>
    <dbReference type="eggNOG" id="KOG1576">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_7_0_1"/>
    <dbReference type="InParanoid" id="Q2GTH0"/>
    <dbReference type="OMA" id="FPRSSYK"/>
    <dbReference type="OrthoDB" id="5286008at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045290">
        <property type="term" value="F:D-arabinose 1-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070485">
        <property type="term" value="P:dehydro-D-arabinono-1,4-lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686:SF1">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="409" mass="43745" checksum="099A844771E5CC6A" modified="2006-03-21" version="1">MAEPRNPSRPPLHTVLPPLVLGTATFNTQYVSDPHSMPYRDIVARALSLGVNAFDTSPYYGPSETLLGTALNDLMNPTTTTTPPTVPLPRSSFFLITKAGRLASTSFDYSPSWTAGEVLAAVRELRRLRDEEGVVRYVGISGFPVDTLCALAEMVRAETGEPLDAVLSYGHFTVQNRALGLPWVGGEEVVQGGDGRRRRVGEDQTRAVDVVLNASILGMGLLTSRGIPADPPSDKTDSLLVHWHPSPPELRIACKKLAELSAAAGERLESVAIRWAIAEWARIAAAAGLGVDIAAPGVGPQKVGVTVCGVTTIGELEETVAEWRGVLASLALGGSDEVYGPARQEKVLSLVRNELWPALQSWLDYTWDSPGAGFVNTRPEADRGITPDDGIVAAFEKAKQDTQSTASTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU27</accession>
    <name>Q2GU27_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226454.1">
        <property type="nucleotide sequence ID" value="XM_001226453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GU27"/>
    <dbReference type="STRING" id="306901.Q2GU27"/>
    <dbReference type="GeneID" id="4395737"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08527"/>
    <dbReference type="eggNOG" id="KOG1211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_14_1_1"/>
    <dbReference type="InParanoid" id="Q2GU27"/>
    <dbReference type="OMA" id="MLNTANC"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="368" mass="39317" checksum="162F492151A8B32B" modified="2006-03-21" version="1">MSIGFAAAAVGVETWGDITYPAQTSGVVGLKPTVGLVPRTGIVPVSSFKDTVGPITRTVKDAAIILSAIAGRCFYDPATIPIPFETVPDYVAACKPDSLRGARIAVSLTPNHIMKAIDAALQVMESAGAEIIRDYDLVGWNYGVSKRAKMPDNVMLREGLESYLRTLATNPHGIYTMADLVNFTAVTPAENAMDYGLEGFVAARDEPHNSSSPEFQAEVHRMLEQGSAIAKMLNTANCDALVVPTMADIPSDLGQNPVIAVPLGFRPLTTRALRSSRMVPKDRASQMIGKGPNSPFSLSFVGRRFSEEKLIGLAYAFEQKTNVLAKSRPCLRSSVPILSGPCPSCRGRIGRFKTGAEKEQGARGSGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUD7</accession>
    <name>Q2GUD7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226344.1">
        <property type="nucleotide sequence ID" value="XM_001226343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUD7"/>
    <dbReference type="GeneID" id="4395136"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08417"/>
    <dbReference type="eggNOG" id="ENOG502RN83">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034763_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GUD7"/>
    <dbReference type="OMA" id="ENDFAFC"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208464" description="AB hydrolase-1 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="110"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="398" mass="43003" checksum="5F515D46498F0E9B" modified="2006-03-21" version="1">MASILIAFVVAALAIKKGGASPTTANQRSCIQIEVPVSVDTTAIKWLQPRVDSSIDAVDWVRYQTTRTSPNNTESMMGRIPIKETFKINGQLCVPPKGAARLEILQIATHGGGFDKRYWDAEIKPKEYSYVEAAVAEGYSIFTYDRLGTGHSSKPNAYDTVQINVQIEILRQLTQLARSGTLVSASKKLSGCTTDARLTKYTPAKIVHVGHSLGSLVSVGLVTNYPTDSDGLVATGFLVPNIPLPGLNVATWGFEFARENDPVLFGDRGSGYMVSATKGNVQLNFLRKGSFEPELLDYAWKIRQTVTVSEFQSLTTGFGQEGAKFKAPFQMVVGENDYGICGGDCNGAYDLDVIKQVYPGATDLDVHVQPGTGHGLTLSINATAGYKASFDFLHKSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUT6</accession>
    <name>Q2GUT6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ87015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225924.1">
        <property type="nucleotide sequence ID" value="XM_001225923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUT6"/>
    <dbReference type="GeneID" id="4394193"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08268"/>
    <dbReference type="eggNOG" id="KOG3021">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1294250_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUT6"/>
    <dbReference type="OrthoDB" id="5772781at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="213" mass="22786" checksum="6C6B904E1447D50A" modified="2006-03-21" version="1">MLPNIEAAILEALGLEATSSKLVSHGGSGFSSTYKLMATKDGQQLTFFIKTGTGPDAEVMFRGEHASLNALHAADPSLHLVPRAHAHGALHSSPGKFFRVTDFIDTRSSAPGGTGFSLAAKLARLHTTPAPTPEGFARSEYGIAVPTCCGGTRQDNAWNRVVGGSSTPTGGCAPCWRRGSISSPQPLRFIRWGLPEWRHVHYAKADLEVWDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV73</accession>
    <name>Q2GV73_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225787.1">
        <property type="nucleotide sequence ID" value="XM_001225786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV73"/>
    <dbReference type="GeneID" id="4394002"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08131"/>
    <dbReference type="eggNOG" id="ENOG502RKYH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_586576_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GV73"/>
    <dbReference type="OMA" id="CYVARED"/>
    <dbReference type="OrthoDB" id="5304511at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="55862" checksum="BAF99110288AFCDB" modified="2006-03-21" version="1">MRCQGGPGFYEQWWFCAMHQADESRSTHENREQQQEQPPPSSPPNPTCGLELLPTEILVAILSAARSTADLHALIQASPRFYQVFIPTKKEVLLNIVATDLGAALRDALAVVLIAPPKLDPQKPTYLEECEHVIRRYEALPHSTDHGGLTSATRGLPIDTIVALTHLNRTVQSLIDEFASTRFPELHKIHPAATTSPPTTTERRRLAAALLRHQVLARIEHGRNRPRVEPNQHRAPETAAMHRFLGLFRPWEAEQLTEVHTFLCESADLAFPPPAPGIRGAHRRHQQPWERQRDAALCDLRLMRCALSARHAGVATDDPAPAAGLRMAFVERFPSLRAGPLPDKGYVLCYVAREDWALRDELYRREDALAPLGFGENGDGDDDAAPPFAWVDAHGGLDCQRWGGYLCRDVLREGQEDVTSLQRTWVRTSLDRWRWLGWVFWDRARVELLKARMPVYETGWLRAGPPSDGEILEAYRRARSRPSRRGSTVQGGEAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVB1</accession>
    <name>Q2GVB1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase DOB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_08093</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225749.1">
        <property type="nucleotide sequence ID" value="XM_001225748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVB1"/>
    <dbReference type="FunCoup" id="Q2GVB1">
        <property type="interactions" value="1017"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GVB1"/>
    <dbReference type="GeneID" id="4394568"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08093"/>
    <dbReference type="eggNOG" id="KOG0948">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002902_5_0_1"/>
    <dbReference type="InParanoid" id="Q2GVB1"/>
    <dbReference type="OMA" id="EIHYMRE"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
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    </dbReference>
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        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="151"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="419"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="694"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="712"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ86840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="726" mass="81313" checksum="B1456C786D759ACF" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVH9</accession>
    <name>Q2GVH9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_08025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225681.1">
        <property type="nucleotide sequence ID" value="XM_001225680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVH9"/>
    <dbReference type="GeneID" id="4394180"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08025"/>
    <dbReference type="HOGENOM" id="CLU_013929_20_3_1"/>
    <dbReference type="InParanoid" id="Q2GVH9"/>
    <dbReference type="OrthoDB" id="5409186at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="6">
        <location>
            <begin position="49"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="494"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ86772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="551" mass="61793" checksum="6591DB01BF71B376" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GW04</accession>
    <name>Q2GW04_CHAGB</name>
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        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CHGG_07850</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 24">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225506.1">
        <property type="nucleotide sequence ID" value="XM_001225505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GW04"/>
    <dbReference type="FunCoup" id="Q2GW04">
        <property type="interactions" value="809"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GW04"/>
    <dbReference type="GeneID" id="4393701"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07850"/>
    <dbReference type="eggNOG" id="KOG0215">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_5_1_1"/>
    <dbReference type="InParanoid" id="Q2GW04"/>
    <dbReference type="OMA" id="LAYCSWC"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000020">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="18">
        <location>
            <begin position="43"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="193"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="456"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="558"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="640"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="15">
        <location>
            <begin position="687"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="1062"/>
            <end position="1147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EAQ86597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1155" mass="129619" checksum="E91F1A075280DE85" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GW86</accession>
    <name>Q2GW86_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Stress-associated endoplasmic reticulum protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_07768</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Interacts with target proteins during translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation and facilitate correct glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the RAMP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225424.1">
        <property type="nucleotide sequence ID" value="XM_001225423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GW86"/>
    <dbReference type="FunCoup" id="Q2GW86">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="GeneID" id="4393491"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07768"/>
    <dbReference type="eggNOG" id="ENOG502SDGZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182424_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GW86"/>
    <dbReference type="OMA" id="SWFTRIT"/>
    <dbReference type="OrthoDB" id="16679at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010580">
        <property type="entry name" value="ER_stress-assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06624">
        <property type="entry name" value="RAMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ86515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="68" mass="7771" checksum="8B8421E85A88B9AD" modified="2006-03-21" version="1">MAQTPQQRRANLKFAKGNEARMGKSEEQIKKRTKDVPKSPISPVWLILLGFVVFGGLVFEIISRIFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWH2</accession>
    <name>Q2GWH2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_07682</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225338.1">
        <property type="nucleotide sequence ID" value="XM_001225337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWH2"/>
    <dbReference type="STRING" id="306901.Q2GWH2"/>
    <dbReference type="GeneID" id="4393607"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07682"/>
    <dbReference type="eggNOG" id="ENOG502SI1A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029872_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GWH2"/>
    <dbReference type="OMA" id="GATITQM"/>
    <dbReference type="OrthoDB" id="10071171at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01830">
        <property type="entry name" value="XynE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053140">
        <property type="entry name" value="GDSL_Rv0518-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43784">
        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43784:SF2">
        <property type="entry name" value="GDSL-LIKE LIPASE_ACYLHYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209079" description="SGNH hydrolase-type esterase domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="3">
        <location>
            <begin position="261"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ86429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="465" mass="48889" checksum="A16F941123B8EB08" modified="2006-03-21" version="1">MLSLPRWAAIAASLLLLSPTSAVPTPEDIGPSRDALAPRADDDWHWVATWTSMPQLVEPNNMPPSPFVSSNTPPSPIRLVVQIGKSQGMLAKNMTGNSSTNLSSTPPPGCGKAWTFSSAGARLRLRRGKNLARARVPITAASMTYKKGLEQRGGHILLHGHTCTLDDGSSAGPLPRGQVAYTDPIDFDAAPQANIAVSIYSQPGQSGSSITGHPGSRTTSHMQSGNRVSAATLSGGANTKHWYFVSAVEAWAPPEAGAFVILGDSITDGRGSTDDGNDRWPDLLLARLQKAGNLSHVGVNNQAAGGNAVLNGGLGPTLLTRYERDALRVAGVKWVMVFEGVNDIGGGGTDSGTQNGIGSRLQQAFEKIARDCKAAGIKTIGGTITPFGGNGQSYSNPTREQTRVKVNDWILKSGTFDATVDFGALIGDPSVKSQLARQYDGGDHLHPNVAGYQAMANGFPLDFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWL7</accession>
    <name>Q2GWL7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trichothecene 3-O-acetyltransferase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_07637</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225293.1">
        <property type="nucleotide sequence ID" value="XM_001225292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWL7"/>
    <dbReference type="STRING" id="306901.Q2GWL7"/>
    <dbReference type="GeneID" id="4394146"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07637"/>
    <dbReference type="eggNOG" id="ENOG502SHVS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026450_5_0_1"/>
    <dbReference type="InParanoid" id="Q2GWL7"/>
    <dbReference type="OMA" id="THHTIID"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054710">
        <property type="entry name" value="Tri101-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF310">
        <property type="entry name" value="FATTY ALCOHOL:CAFFEOYL-COA ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22664">
        <property type="entry name" value="TRI-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trichothecene 3-O-acetyltransferase-like N-terminal" evidence="3">
        <location>
            <begin position="43"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ86384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="462" mass="50400" checksum="51950A0A20004F9F" modified="2006-03-21" version="1">MGSNQDDVITQQPGAGEDGVGSSNVNLDRLPDLMGQFPVLNAYTHITFGFELPLDVDRDAITSALQTSLDRLIELIPWLGWQIGLESGVRTTVPWPEDTPRVLLHVKNCDDIVVPMAQLLAAGIPINKLDAKVLAPWPALPQPHGLTGPVPVITLQANFVRGGLILNFSSHHTVMDGTANLQVPKLFAAILNGDTIPEADLQQANRDRRGLIELIPRSEPMKDYSHLRGPPGYRFTLPASAPIWCHFNMPMASLSKLTKSARDPSRPVNEDDVLIAFFWQRLCAARIARGIARDTVSKISRAIDARVALGIPPTYLGAQVHMAITRLPMGQVASLTLLQVAQVLRRALADANTPWAIRSLVTFIAREPDRSRLLYNGPHDGNTDVGATSSLNMAHARPPHWGPVLGPSRFFSRSNGAPIPGSFTVYSPDGAGFVRMCICLPVDDLEALKKDALWKQHTKFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWU1</accession>
    <name>Q2GWU1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_07563</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225219.1">
        <property type="nucleotide sequence ID" value="XM_001225218.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4393414"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07563"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001613_8_1_1"/>
    <dbReference type="InParanoid" id="Q2GWU1"/>
    <dbReference type="OMA" id="YICENAR"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF6">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="5">
        <location>
            <begin position="287"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="4">
        <location>
            <begin position="554"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="1176"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="480"/>
            <end position="505"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
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        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
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        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
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        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
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        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
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        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ86310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1671" mass="191601" checksum="262096BDA90F1ED3" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWU8</accession>
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        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
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        <name evidence="4" type="ORF">CHGG_07556</name>
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        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
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            <taxon>Chaetomium</taxon>
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    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07556"/>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="272"/>
            <end position="460"/>
        </location>
    </feature>
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        <location>
            <begin position="916"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1007"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ86303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1112" mass="123574" checksum="375031101680C449" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX24</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CHGG_07480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_799299_0_0_1"/>
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    <dbReference type="OrthoDB" id="4177740at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
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    </dbReference>
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        <location>
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            <end position="320"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="320" mass="36925" checksum="E408574FA54247D1" modified="2006-03-21" version="1">MPAKLATTENLRRAMVEQKQLRDISEMKAKFDHLTTNACVIDQPTLDSLGVVLGQPLDIDDSGSFWGSDTRFFQPWVPDELLDEAASNRAPWSWKDKIRETWYKQPESKYGELKAQWFNGCLEDLYEMDKELWEPWVVDSYTIREHSGLDLPLCRFRIFDPATDDFVEREYSPEAVYFPVDRTKPHVACFAIDSNHPPGDKVLRSDLHYAIQLVRFRLEKGQHTGHHTKPGLIYTIERDQWARITQVHFDTNAHKLVLRQSRQLDLCGPTPPPDAFLLLRWMTSRPAGDTEYVDEEEPPKEEVARDEPSSAAPKLLLGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXN0</accession>
    <name>Q2GXN0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_07274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ86021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001224929.1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="306901.Q2GXN0"/>
    <dbReference type="GeneID" id="4394557"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07274"/>
    <dbReference type="eggNOG" id="KOG2669">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042070_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GXN0"/>
    <dbReference type="OMA" id="LWMQRLK"/>
    <dbReference type="OrthoDB" id="10069473at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099122">
        <property type="term" value="F:RNA polymerase II C-terminal domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17003">
        <property type="entry name" value="CID_Rtt103"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047883">
        <property type="entry name" value="Rtt103-like_CID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460:SF0">
        <property type="entry name" value="CID DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ86021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="428" mass="46394" checksum="0D04F0EAB1CDF8C0" modified="2006-03-21" version="1">MAYTDDAVLSKLSALNETHESIATTAQWIMFHRRHASQTVHLWLNKLKDLPSAKRLNMIYLANGSYLHPKIVRIATDLFPEVVQQSKARHKEDFLNAFSPFIADATSVTYKGAPVDVQGKLRRVMDVWRERSIFDKEVMQDLEHRLAEIDKARPAANAGGFGGNAFSSSGPSIPPELIPLVAPQQATTKASQPMKNSLNTANTEYEKLTDPATTTAALPVQAARLSGLLKTLANAEGAVTQCIRARKDLIKELEGILATNREALDADEKQMMELSGRRTEVEQKKQAVEMAIIGNLSNAEETSPQGHGSVSPVPEPDRPQVEALTPPHVQDHIDGAYGTSSAGHGAQNGHQQPVPFHGPPAPANAQPGFSGAAPDLEMLSNLASQYQAVPIAGNKKRKIESSDEFPDLGADDGIDADVKEMLRKDSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXN3</accession>
    <name>Q2GXN3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA/RNA-binding protein Kin17 WH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_07271</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KIN17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224927.1">
        <property type="nucleotide sequence ID" value="XM_001224926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXN3"/>
    <dbReference type="FunCoup" id="Q2GXN3">
        <property type="interactions" value="294"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GXN3"/>
    <dbReference type="GeneID" id="4394554"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07271"/>
    <dbReference type="eggNOG" id="KOG2837">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030065_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GXN3"/>
    <dbReference type="OMA" id="QVCERQM"/>
    <dbReference type="OrthoDB" id="10266249at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2030:FF:000001">
        <property type="entry name" value="DNA/RNA-binding protein KIN17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2030">
        <property type="entry name" value="DNA/RNA-binding protein Kin17, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056767">
        <property type="entry name" value="C2H2-Znf_KIN17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019447">
        <property type="entry name" value="DNA/RNA-bd_Kin17_WH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037321">
        <property type="entry name" value="KIN17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038254">
        <property type="entry name" value="KIN17_WH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805:SF0">
        <property type="entry name" value="DNA_RNA-BINDING PROTEIN KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805">
        <property type="entry name" value="KIN17 KIN, ANTIGENIC DETERMINANT OF RECA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25095">
        <property type="entry name" value="C2H2-zf_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10357">
        <property type="entry name" value="WH_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01253">
        <property type="entry name" value="Kin17_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA/RNA-binding protein Kin17 WH-like" evidence="6">
        <location>
            <begin position="52"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ86018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="333" mass="37646" checksum="8F3C8670B9C5301B" modified="2006-03-21" version="1">MGKAEPGSTKYLANKMKQKGLTRLRWYCQICEKPCRDENAFKMHCQSESHMRRALEAGQNFKSVQEDYSKQFLAEFVSLLKTAHGEKSVHANKFYQEVIARRDHVHLNATRWHSLTDFVKHISREGIVRAEEKEDGIFIAWIDDSPEAMKRREAVRRKEMQDKGDEEREQMLLREQIRRAQKDAEARGVLGADGEAEEEGKELKREEGEKIKLSFGAKTAKSTTPEDKVSVPDPKKEGGGPETTNGAGDGEAKKADDTKPAETATAVKPVSLKFGAKPQPKNVFKNAFAGAPKKIMAAQPKKMSEAERIMKEELERKRMREAGGGPPHKRPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXN5</accession>
    <name>Q2GXN5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Association with the SNF1 complex (ASC) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_07269</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224925.1">
        <property type="nucleotide sequence ID" value="XM_001224924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXN5"/>
    <dbReference type="FunCoup" id="Q2GXN5">
        <property type="interactions" value="383"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GXN5"/>
    <dbReference type="GeneID" id="4394588"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07269"/>
    <dbReference type="eggNOG" id="KOG1616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026512_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GXN5"/>
    <dbReference type="OMA" id="YYSASAH"/>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000562">
        <property type="entry name" value="Snf1 kinase complex beta-subunit Gal83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="5">
        <location>
            <begin position="362"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="320"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ86016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="472" mass="50532" checksum="9FA8EB45A7457C3A" modified="2006-03-21" version="1">MGNSPSTSKNASQSSSSQTSSQHDRPVRREARNPIPVQGLRAAAPPEPSLTQAQGTSVQPPSSSSSSVASRPKPLQPRPLGSGVAASGYSTSSSPATAASSTSSAKPVDVNQGKPSPHHAPAKPVAVPNSHNSPSSPRSPRSPRSEDSYEVAAMPVSSVQDVSYLTRPPRLPLPIEEEVHTPGSPIIAPTDVGEPVDDVEGLDNAALAHPTSNLSDTIVEEEDAEELLVDKTRPTVPTKLEWRHGGDKVYVTGTIFQWNRKTRLHPVEGEPGVFATTIDILPGTHHIRFLVDGQMQTTPDYPTTVDFGNNLVNYIEVSPDDLQSTPADGEGSSEGKTAPQQTDADPTPAEEDGQVPQPRDREIPPASQFEQKIPKYLIDQDQPEDSPQYHHAVRATEKLPNPPGLPGFLSKPILNAATPRKDDNSVLTQPNHTVLNHLATSSIKNNVLAVSATTRYKSKYVTTIMYKPTTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXW8</accession>
    <name>Q2GXW8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gamma-glutamyltranspeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224842.1">
        <property type="nucleotide sequence ID" value="XM_001224841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXW8"/>
    <dbReference type="STRING" id="306901.Q2GXW8"/>
    <dbReference type="MEROPS" id="T03.025"/>
    <dbReference type="GeneID" id="4394610"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07186"/>
    <dbReference type="eggNOG" id="KOG2410">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014813_3_1_1"/>
    <dbReference type="InParanoid" id="Q2GXW8"/>
    <dbReference type="OMA" id="EGNMVSY"/>
    <dbReference type="OrthoDB" id="2015213at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052896">
        <property type="entry name" value="GGT-like_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881:SF1">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="627" mass="65476" checksum="3EB8B9F094A6B32A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYN3</accession>
    <name>Q2GYN3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_06921</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224577.1">
        <property type="nucleotide sequence ID" value="XM_001224576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYN3"/>
    <dbReference type="STRING" id="306901.Q2GYN3"/>
    <dbReference type="GeneID" id="4393741"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06921"/>
    <dbReference type="eggNOG" id="KOG0777">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_10_0_1"/>
    <dbReference type="InParanoid" id="Q2GYN3"/>
    <dbReference type="OMA" id="DLYWTHN"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF72">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G01210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ85668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="715" mass="78840" checksum="8B25E0A9F5A4AD28" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZ02</accession>
    <name>Q2GZ02_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_05244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224458.1">
        <property type="nucleotide sequence ID" value="XM_001224457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZ02"/>
    <dbReference type="STRING" id="306901.Q2GZ02"/>
    <dbReference type="GeneID" id="4393041"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05244"/>
    <dbReference type="eggNOG" id="ENOG502S0H4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083369_3_0_1"/>
    <dbReference type="InParanoid" id="Q2GZ02"/>
    <dbReference type="OMA" id="LQWRRCA"/>
    <dbReference type="OrthoDB" id="152248at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025649">
        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847:SF1">
        <property type="entry name" value="PSEUDOURIDINE SYNTHASE RSUA_RLUA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ88625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="21827" checksum="24421D2D6F84FAF3" modified="2006-03-21" version="1">MRLTSLLFAGAAAAAVITPNPSESLGFTAPAPGEIKIINVTAIGSGCPAGHAYINVDATGTIFDVAFDEYIVSAGPGSSVSDSRKNCRISINLQFPSGYQFSVIETRFTGYASLSEGQTGTCRAGYTFAGDSTQEVVFQKNILAPYEDNYNMIAGVGVESFSRCGGTTAILNVNSEIRITPISTPNRGTMTVRNPYKVALQWRRCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZ94</accession>
    <name>Q2GZ94_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_05152</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224366.1">
        <property type="nucleotide sequence ID" value="XM_001224365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZ94"/>
    <dbReference type="STRING" id="306901.Q2GZ94"/>
    <dbReference type="GeneID" id="4392931"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05152"/>
    <dbReference type="eggNOG" id="ENOG502SH49">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011017_3_1_1"/>
    <dbReference type="InParanoid" id="Q2GZ94"/>
    <dbReference type="OMA" id="ECEKRAM"/>
    <dbReference type="OrthoDB" id="3037908at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF3">
        <property type="entry name" value="C6 FINGER DOMAIN TRANSCRIPTION FACTOR DBAA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ88533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="455" mass="50813" checksum="039DEDB606D2C2FD" modified="2006-03-21" version="1">MAAHRRTGSSHGVGATGQPRQLPGSACEECRKRKLRCDRQRPQCGTCADAGIVCEINNNRLARGPKKGDLKALRSRIGTSDDPHICPSELFDLQISTHAAVTTEDHIRGRLDARRPLYFDRVHPNVPIFNQSRYFARVRQNPCIEGPTSMLCLQYAMWTLAMALSSQFESSRELLYNETRQMLEALDLADDDLQPVRIEQVQAWLLVSFYELARASYRRALISAGRAFRLVQLARLHEVDGPGNSVEEEDPVVREERRRTFWMAYSLDRLICMRSRCPLTLTEEVICTRLPSPELAFQSGHPIPGCFLPEALASGDHNFISPFAGSVMVISICGRALSHGQASGVERAFGTASLDFWLRHEWLDGMLGRTLESLTMNSPVASAMADPMVFFAFMMAHATTIFMCQIAEASGIDSHCRPTVADCQGRATQAAREIARMAKAHEHIGYFKLMQSPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZL7</accession>
    <name>Q2GZL7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_05029</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224243.1">
        <property type="nucleotide sequence ID" value="XM_001224242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZL7"/>
    <dbReference type="STRING" id="306901.Q2GZL7"/>
    <dbReference type="GeneID" id="4391826"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05029"/>
    <dbReference type="eggNOG" id="KOG3467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109117_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GZL7"/>
    <dbReference type="OMA" id="AMIYDDA"/>
    <dbReference type="OrthoDB" id="3919494at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000012">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ88410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="133" mass="14883" checksum="D226F1EBA44F1FC0" modified="2006-03-21" version="1">MPPTVPQRGGPSGLKRSVAGKTVMKTGAKRHRKIIKDCIRGITKPAIRRMARRGGVKRISATIYDEARHALKIFLATVIRDVVTYTEYRNAKTVTVNDVIFALRRIGRPIYGFDPDTYSAKKNSVAVQKDSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H011</accession>
    <name>Q2H011_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224099.1">
        <property type="nucleotide sequence ID" value="XM_001224098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H011"/>
    <dbReference type="GeneID" id="4392592"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04885"/>
    <dbReference type="eggNOG" id="ENOG502S6PS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_7_1_1"/>
    <dbReference type="InParanoid" id="Q2H011"/>
    <dbReference type="OMA" id="DVEDEWM"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF106">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="37932" checksum="0EB8082779D755AD" modified="2006-03-21" version="1">MDEDGVIEPLVDDDLAEAAGEVTSDYDPSDGETTFGSLTSSVGEHVWEYGRPRRYHAYRYGRYPIPNDEEEYKRESLRHMMLKELLGGKLYLAPIGDNPQKIIDLGTGFGEWAIEVGEKFPSARVTGVDLSPIQPHWIPPNVDFIVDDIEDQWVHANDFDFAHFRFVHSIIRASRTALRNVLENLKPGGWVEIKDILPRVSSDDNTVSPEHPLAKFYTMVGSALREKYGFNIWIMETLPSLLEELGFVNIQRKVFHMPLGEWARDSHLRVLGGYYREVMVDFVSAMAARPLVEAGLDKEEIADLVRDINVVLSNRRIHAYTPIHFVWAQKPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H041</accession>
    <name>Q2H041_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine protein phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224069.1">
        <property type="nucleotide sequence ID" value="XM_001224068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H041"/>
    <dbReference type="GeneID" id="4392800"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04855"/>
    <dbReference type="eggNOG" id="ENOG502SN7S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094654_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H041"/>
    <dbReference type="OMA" id="YMRYSGH"/>
    <dbReference type="OrthoDB" id="5409477at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="25276" checksum="A7C7B666CBDED732" modified="2006-03-21" version="1">MDPDCAICHAPAALACECEAKGLEVAVRQAESRMMQSIYNDIRSWVRAHAQDYILEYFRLLTERRKAAHAQHLERLSAHAYHYYHSQPHPNELAAAQAQLKRGIDEDWQASVQRYPEVLEYFYSLVELTLPDDNEQAVKDPPLSALNGGPRKGARRVGAATTVASGPSLTAHERDLPMAARGRTPPPLEPLRERRTPAPRERRQSYRGPPPPPPPPPSYYPQPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H060</accession>
    <name>Q2H060_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224050.1">
        <property type="nucleotide sequence ID" value="XM_001224049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H060"/>
    <dbReference type="GeneID" id="4392337"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04836"/>
    <dbReference type="HOGENOM" id="CLU_1626828_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H060"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="163" mass="18173" checksum="B4DDD64413E47ACC" modified="2006-03-21" version="1">MVRQGPYFQYQETGGLTPRLCCATGDALPSEAYKREEDKSSSSRSAGGNSNRGSWKEWVETSVRHDYPGIFPGKANNLSSSERAKKREAHPRSEAQNGRAEVLECNAESNRGDFSRWAPCGSKLTSPRAESKRAPRCRAAETAERHQNDDAVAYHSKNRERNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0P7</accession>
    <name>Q2H0P7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_04649</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223863.1">
        <property type="nucleotide sequence ID" value="XM_001223862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0P7"/>
    <dbReference type="GeneID" id="4392118"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04649"/>
    <dbReference type="eggNOG" id="ENOG502S5NV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028977_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H0P7"/>
    <dbReference type="OMA" id="CEPACAF"/>
    <dbReference type="OrthoDB" id="5575144at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208661" evidence="8">
        <location>
            <begin position="23"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="281"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ88030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="455" mass="49868" checksum="930BEF94111D1AD0" modified="2006-03-21" version="1">MRGAIGSGPVLHFLLGLSPLHANTANKATAQRPCSRCMSTNKEGACIDVQHKKRGRPRLRDDSQAKYEGSRFGSAVDAMRRPLSSAYGPGPPLGMVYDDPLRRIQSYRVLKSQPAESIAPRFPERGLASDANMYPAPLSIATARVHEEPVAYLTIGLEFARASPSFLSAIGRASVTGLEITNVLAVEERPRATRLQQQAQEEQARKDPAYLPPIFNDRSDAVMQSLSFTPEEVSRYPLHWLDTFTFLGDDGQPRQIPVRAGLATRNSIYFVVLLLNRGSRPSYPTPSPSLRDMSGSFEPGLQHYSQPTPLSATFDPRQSRLSDPGYDPRPSGQQAGGSLHMLPARSPGLSSAYGISPSRPDYPITPRTFQTPRTELHSASRAPQPADYQLLPLPRIRSPPMGTTQQTEPPQTQQSHSQPQPPPPLPPPPPYQSREERSRIGIGGLLEQPGQTKSP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-23" modified="2025-02-05" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0S9</accession>
    <name>STU1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Protein STU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">STU1</name>
        <name type="ORF">CHGG_04617</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CLASP family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223831.1">
        <property type="nucleotide sequence ID" value="XM_001223830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0S9"/>
    <dbReference type="STRING" id="306901.Q2H0S9"/>
    <dbReference type="GeneID" id="4391605"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04617"/>
    <dbReference type="eggNOG" id="ENOG502QT5T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004060_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H0S9"/>
    <dbReference type="OMA" id="GNAPHDF"/>
    <dbReference type="OrthoDB" id="46159at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060172">
        <property type="term" value="P:astral microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF9">
        <property type="entry name" value="CLIP-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0493">Microtubule</keyword>
    <keyword id="KW-0498">Mitosis</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <feature type="chain" id="PRO_0000272285" description="Protein STU1">
        <location>
            <begin position="1"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT 1">
        <location>
            <begin position="95"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT 2">
        <location>
            <begin position="167"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="476"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="704"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="1111" mass="120187" checksum="8B64DA273C63553C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1F0</accession>
    <name>Q2H1F0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223610.1">
        <property type="nucleotide sequence ID" value="XM_001223609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1F0"/>
    <dbReference type="GeneID" id="4392166"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04396"/>
    <dbReference type="eggNOG" id="ENOG502SGAZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044875_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H1F0"/>
    <dbReference type="OMA" id="LECFHPS"/>
    <dbReference type="OrthoDB" id="9981546at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="4"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="329" mass="36127" checksum="776CFDF21E4FD1B9" modified="2006-03-21" version="1">MENSQTFDSLPNELLISILSQLPTSSLLPLITTSRRIYSIALRILKQRLSHATSQPDQRLMLECYHPSEKLYTPYLYCNYLRTDSFASAEPTARGTSGTGGLAGIYAHFRPVEQDEDRPRRATRGFRRHLTPTPTTTATPNNEEPRPSTDVYLDDDESFTQLCAVTNLVRMGPKPGLFRSHVNVSEGVLRVWRDWLAERAAAGGRRGERAGREAGEAGQGQEEEEEEEEGGGGGGDGGGGDEGEGEGGDEDGVLWADASRDVGVRFRVAEKDIRGQHPVLVASDEQLPVAYRLEFGELLVRATTLLLMVEKSEMQDFAAEGKAIVLASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1F7</accession>
    <name>Q2H1F7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_04389</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223603.1">
        <property type="nucleotide sequence ID" value="XM_001223602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1F7"/>
    <dbReference type="STRING" id="306901.Q2H1F7"/>
    <dbReference type="GeneID" id="4393095"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04389"/>
    <dbReference type="eggNOG" id="KOG0758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1758589_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H1F7"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015227">
        <property type="term" value="F:O-acyl-L-carnitine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902603">
        <property type="term" value="P:carnitine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF4">
        <property type="entry name" value="CONGESTED-LIKE TRACHEA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="57"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ87770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="148" mass="15315" checksum="61177F3FF279D0B6" modified="2006-03-21" version="1">MASSPSSSGSTAAAVNQKLQSSLPNAVSEKLPHIPENKEELKAEIKAEAKAVTSAGFAQLRSFVAGGFGGVCAVVVGHPFDLVKVRLQTAEKGVYSSAMDVVRKSVAKDGLRRGLYAGVSAPLVGVTPMCMSIPSTPTNWSGSCVEQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1M9</accession>
    <name>Q2H1M9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_04317</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223531.1">
        <property type="nucleotide sequence ID" value="XM_001223530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1M9"/>
    <dbReference type="STRING" id="306901.Q2H1M9"/>
    <dbReference type="GeneID" id="4391834"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04317"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005688_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H1M9"/>
    <dbReference type="OMA" id="YPRKDGR"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF71">
        <property type="entry name" value="CARBOXYPEPTIDASE TRE2, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="374"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="6">
        <location>
            <begin position="562"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="5">
        <location>
            <begin position="809"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ87698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="932" mass="102804" checksum="DEB8A085A1288C83" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H255</accession>
    <name>Q2H255_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_04141</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223355.1">
        <property type="nucleotide sequence ID" value="XM_001223354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H255"/>
    <dbReference type="GeneID" id="4391715"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04141"/>
    <dbReference type="eggNOG" id="ENOG502RS9S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048625_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H255"/>
    <dbReference type="OMA" id="FEPTHAC"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057231">
        <property type="entry name" value="DUF7909"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25486">
        <property type="entry name" value="DUF7909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209205" description="WSC domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="229"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ87522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="344" mass="36980" checksum="4BE3A53478376E22" modified="2006-03-21" version="1">MINRRTISALFAGAALSSACTIPTEPLDNNIAYPFRAQVQNASRPEVHNQYLNLLQAGGGDHHLFIGPVGVPTYDLTLVDGVINHVPNGVRLVIGGEIDHTTKLFSTGRGDDRAIFEPTYACNPDTDELQIELRFVTWQNHPTGGHVCVRHAFDGSHEFRYSPPGNTLIDVNRECIKVTLVVIPTTDLPPPTSSSTTLSTVTIPATSTTSAAGPTGTPTAPFTDLTASGFRFLGCAPEERWTTDGPFRTLSGASEASTDAMTNERCAAFCTARGFRYAGTEWRQECWCGDEVAATRVPATTAASLENCKYVCTGDSTQYCGGDAWLSLYEKCAEGGPCENVVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H337</accession>
    <name>Q2H337_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Postreplication repair E3 ubiquitin-protein ligase RAD18</fullName>
            <ecNumber evidence="5 17">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase RAD18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CHGG_03809</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with E2 UBC2, forming a complex with ubiquitin ligase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the RAD18 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 17"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223023.1">
        <property type="nucleotide sequence ID" value="XM_001223022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H337"/>
    <dbReference type="STRING" id="306901.Q2H337"/>
    <dbReference type="GeneID" id="4392813"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03809"/>
    <dbReference type="eggNOG" id="KOG0287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_344175_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H337"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23148">
        <property type="entry name" value="RING-HC_ScRAD18-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000172">
        <property type="entry name" value="E3 ubiquitin-protein ligase RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039577">
        <property type="entry name" value="Rad18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004580">
        <property type="entry name" value="Rad18_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00599">
        <property type="entry name" value="rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14 17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13 17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 17" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12 17" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 16 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="29"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="20">
        <location>
            <begin position="261"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="102"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="211"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="324"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="214"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU368093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EAQ87190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="822" mass="88662" checksum="0B7CE5D234FFABBC" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H388</accession>
    <name>Q2H388_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_03758</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222972.1">
        <property type="nucleotide sequence ID" value="XM_001222971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H388"/>
    <dbReference type="STRING" id="306901.Q2H388"/>
    <dbReference type="GeneID" id="4392486"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03758"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_2_7_1"/>
    <dbReference type="InParanoid" id="Q2H388"/>
    <dbReference type="OMA" id="GMGPIVC"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="386"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ87139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="910" mass="100928" checksum="A7B81CE3D0CF755B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3N6</accession>
    <name>Q2H3N6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222824.1">
        <property type="nucleotide sequence ID" value="XM_001222823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3N6"/>
    <dbReference type="GeneID" id="4390969"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06729"/>
    <dbReference type="eggNOG" id="ENOG502SI94">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034763_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3N6"/>
    <dbReference type="OMA" id="NLHAVKY"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="55"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="332" mass="35509" checksum="331DBB44F9B93292" modified="2006-03-21" version="1">MESNVAITTSFSRSWRGDICATNGTLTISDTFTIKGTYCTPKGTTADKPPKGLQILVHGITYNKTMWAGFGFSPSNYSWHTAATSRGYATLALDRLGHGANPQHPDPLSVVQPQVQIDIMHAIFAAARSATAPLNAVLGRVYDKVVFVGHSYGAFLGAALGAQYPADADALVLAGYSSYYDFSDMIGADWASAADHDPARFGGLAKGYIVMADETQRTETFYVGGYDAAIPPVDYAYEDTLTVGEIGALAAILGPAVGYTGPVLAVTSVEDAFFCEAPKAKCEEHLTATADAFPDAESFDYFAPENTGHDLTLHYTARDTAEQVHDWLDEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3X2</accession>
    <name>Q2H3X2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Xylosidase/arabinosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_06643</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222738.1">
        <property type="nucleotide sequence ID" value="XM_001222737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3X2"/>
    <dbReference type="GeneID" id="4391508"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06643"/>
    <dbReference type="eggNOG" id="ENOG502QTYK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009397_4_1_1"/>
    <dbReference type="InParanoid" id="Q2H3X2"/>
    <dbReference type="OMA" id="TEDIPWV"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18619">
        <property type="entry name" value="GH43_CoXyl43_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052176">
        <property type="entry name" value="Glycosyl_Hydrlase_43_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772:SF2">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ90024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="37162" checksum="A656ECDE839AC5F6" modified="2006-03-21" version="1">MAPLITHLYTADPSAHVFEGKVYIYPSHDRETDIQFNDNGDQYDMADYHVFSTDSLDPVAPVTDHGVVLKTEDIPWVSKQLWAPDAAFKDGKYYLYFPARDKEGIFRIGVAVGDRPEGPFKPDPEPIKGSYSIDPATFVDEDGQAYMYFGGLWGGQLQCYQKGNDIFEAEWQGPKEPSGEGARALGPRVAKMTDDMRQFATEVKEIQILAPETGEPIAADDHDRRFFEAAWMHKYNGKYYFSYSTGDTHYLAYGVGDSPYGPFTYGGRILEPVLGWTTHHSIVEFKGRWWLFHHDCELSKGVNHLRSVKIKEIFYDKDGKIVTEKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3Y6</accession>
    <name>Q2H3Y6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial carrier protein RIM2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_06629</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5-methyl-UTP(out) + UTP(in) = 5-methyl-UTP(in) + UTP(out)</text>
            <dbReference type="Rhea" id="RHEA:73523"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:63527"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222724.1">
        <property type="nucleotide sequence ID" value="XM_001222723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3Y6"/>
    <dbReference type="FunCoup" id="Q2H3Y6">
        <property type="interactions" value="393"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H3Y6"/>
    <dbReference type="GeneID" id="4390136"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06629"/>
    <dbReference type="eggNOG" id="KOG0757">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_0_1"/>
    <dbReference type="InParanoid" id="Q2H3Y6"/>
    <dbReference type="OMA" id="WVMYEQM"/>
    <dbReference type="OrthoDB" id="269120at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000079">
        <property type="entry name" value="Mitochondrial carrier protein RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000088">
        <property type="entry name" value="Mitochondrial carrier protein RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="55"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="171"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="287"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ90010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="41789" checksum="957BDA8928BF6DE2" modified="2006-03-21" version="1">MASASVARSAMPGGPGKSISHTDAPLTQSRETGDVNPESRQGTPIVNRDKSTKAQNPWAHLVAGGIGGMTAAALTAPLDVLKTRLQSDFYQAQIRASRASIAAPMNPFRTAAFHFNETMSILGSVYRQEGPRALFKGLGPNLVGVIPARSINFFTYGNGKRIIGEYFGNKDSPWVHLTAGSISGVVTSTVTNPIWMVKTRLQLDKNMAIESGGIAKRRYKNSLDCIRQVLRDEGIRGLYKGMSASYLGVAESTMHWMLYEQIKRSLVRREERIALSGRSKGWWDHTVDWTGKFGAAGFSKFIAAVITYPHEVARTRLRQAPMADGRPKYTGLIQCFKLVFKEEGMLGLYGGMTPHLLRTVPSAAIMFGMYEGILRLLRTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4N0</accession>
    <name>Q2H4N0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_06385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222480.1">
        <property type="nucleotide sequence ID" value="XM_001222479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4N0"/>
    <dbReference type="STRING" id="306901.Q2H4N0"/>
    <dbReference type="GeneID" id="4390112"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06385"/>
    <dbReference type="eggNOG" id="KOG3015">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1326228_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4N0"/>
    <dbReference type="OrthoDB" id="5322896at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="207" mass="21585" checksum="F80EA14E0DE1AF02" modified="2006-03-21" version="1">MAPATRLCLLPLRPITSAARGTARVAATTNVATRSIHTIPAQSAKVVPVYGTGPPPEPPQPSAEFAAEIVPVLTDGSLLPRPQAPGTREVVQGWILSLSAFELAALERATLAGKSLLAAARLVAEWSEEGAQAAVPVSVQGGEGGGRERFGVEEAARAVSLEVEWQTKKWGEVEDTHDVEKEDLRRQLGSAVLLVSGTGNGTGPKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4S1</accession>
    <name>Q2H4S1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_06344</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222439.1">
        <property type="nucleotide sequence ID" value="XM_001222438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4S1"/>
    <dbReference type="STRING" id="306901.Q2H4S1"/>
    <dbReference type="GeneID" id="4391503"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06344"/>
    <dbReference type="eggNOG" id="KOG4730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_530170_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4S1"/>
    <dbReference type="OMA" id="YGMISPY"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762:SF1">
        <property type="entry name" value="D-ARABINONO-1,4-LACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209275" description="FAD-binding PCMH-type domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="3">
        <location>
            <begin position="32"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ89725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="532" mass="59181" checksum="958CBCE6E45F94BE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4V2</accession>
    <name>Q2H4V2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_06313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06313"/>
    <dbReference type="eggNOG" id="ENOG502SKGN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011750_0_0_1"/>
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    <dbReference type="OMA" id="YLPWCLR"/>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="622"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="665"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="784" mass="86271" checksum="15E2CC1C437B2FD2" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4W5</accession>
    <name>Q2H4W5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">D-arabinono-1,4-lactone oxidase</fullName>
            <shortName evidence="9">ALO</shortName>
            <ecNumber evidence="4 9">1.1.3.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">L-galactono-gamma-lactone oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_06300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23756"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16292"/>
            <dbReference type="ChEBI" id="CHEBI:58277"/>
            <dbReference type="EC" id="1.1.3.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Cofactor biosynthesis; D-erythroascorbate biosynthesis; dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.37" evidence="4 9"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001222394.1"/>
    </dbReference>
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        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H4W5"/>
    <dbReference type="GeneID" id="4390671"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06300"/>
    <dbReference type="eggNOG" id="KOG4730">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003896_4_1_1"/>
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        <property type="reaction ID" value="UER00766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032473">
        <property type="term" value="C:cytoplasmic side of mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031489">
        <property type="term" value="F:myosin V binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070485">
        <property type="term" value="P:dehydro-D-arabinono-1,4-lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
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        <property type="project" value="EnsemblFungi"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ALO_C"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030654">
        <property type="entry name" value="Sugar_lactone_oxidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01678">
        <property type="entry name" value="FAD_lactone_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762:SF1">
        <property type="entry name" value="D-ARABINONO-1,4-LACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000136">
        <property type="entry name" value="LGO_GLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ89681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="527" mass="59117" checksum="B570110B5ED6FEAD" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4Y9</accession>
    <name>Q2H4Y9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase assembly protein COX16, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cytochrome c oxidase assembly protein cox16, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_06276</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COX16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222371.1">
        <property type="nucleotide sequence ID" value="XM_001222370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4Y9"/>
    <dbReference type="FunCoup" id="Q2H4Y9">
        <property type="interactions" value="106"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H4Y9"/>
    <dbReference type="GeneID" id="4391064"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06276"/>
    <dbReference type="eggNOG" id="ENOG502S9GT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131611_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H4Y9"/>
    <dbReference type="OMA" id="VNMKDEY"/>
    <dbReference type="OrthoDB" id="5516033at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020164">
        <property type="entry name" value="Cyt_c_Oxase_assmbl_COX16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130:SF14">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX16 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14138">
        <property type="entry name" value="COX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ89657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="92" mass="10635" checksum="E9F9F5310F98A6D6" modified="2006-03-21" version="1">MARRPFLLFGLPFLSVIVGASFVLTPATAIRYERHDRRVRTLTRDEELGVGRAGTGRKVDIREEYYRLSAKDNDNWEQKRVKRLKGESDGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H553</accession>
    <name>Q2H553_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_06212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222307.1">
        <property type="nucleotide sequence ID" value="XM_001222306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H553"/>
    <dbReference type="GeneID" id="4390395"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06212"/>
    <dbReference type="HOGENOM" id="CLU_2145579_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H553"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="112" mass="12483" checksum="F59F7B2F2C6CD875" modified="2006-03-21" version="1">MAKANLARLATLVAIKRGEPGGRSGSRIPLSRGLPLTILKTIGFWLGMRTMLTEKETPRSRPPSRCHRLDRHHSWAQGLPSCSTTLFPTKSPMDLWIRWSMIVERASMDGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6L3</accession>
    <name>Q2H6L3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_05702</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221797.1">
        <property type="nucleotide sequence ID" value="XM_001221796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6L3"/>
    <dbReference type="STRING" id="306901.Q2H6L3"/>
    <dbReference type="GeneID" id="4390554"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05702"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007681_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H6L3"/>
    <dbReference type="OMA" id="TGMMHGW"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF23">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="472"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="590"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ89083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="857" mass="94846" checksum="A769FDB2918C355F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H704</accession>
    <name>Q2H704_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosome biogenesis protein Mak11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221656.1">
        <property type="nucleotide sequence ID" value="XM_001221655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H704"/>
    <dbReference type="FunCoup" id="Q2H704">
        <property type="interactions" value="545"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H704"/>
    <dbReference type="GeneID" id="4390006"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05561"/>
    <dbReference type="eggNOG" id="KOG0294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030368_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H704"/>
    <dbReference type="OMA" id="KLHQMKY"/>
    <dbReference type="OrthoDB" id="308449at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051959">
        <property type="entry name" value="PAK1-Kinase_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675:SF1">
        <property type="entry name" value="P21-ACTIVATED PROTEIN KINASE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675">
        <property type="entry name" value="PAK1 INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="51911" checksum="61AD0852AE36C167" modified="2006-03-21" version="1">MAKRKREAPPEGEHVNTKPSAKKAKALVKTPQSTAFKLDSNGPVTIQIIAGSYDRVLHGVTATIMPTPAVPSTKKKSKGNTPPPQEAKFADTFLFNAHNSAVRCLALSPVSAPTPGQSQKVLLATGSTDERINIYNLSAHPPSARAADDQQALSALAPRPILENPKNRELGTLLHHTSNITRLAFPNRSKLLSAAEDSTCPIPKMQGRPSGDTAALGGAPAGVNDFAVHPSNKIMISVSKGERCMRLWNLETGKKSRVLNFERAVLGECGEGRHSTGEARRIVWGRARGGDDEFAVAFERDVLVFGMDCVPKCRAMGDIKTKVLSLCYVETEGSGEETVLAVSTEDGRVLFFSTAAEDLAKPAEGKTVPVAKLVGQLGGKEAGVSGRIKDFKVLPVEDEDGKRSFFVAGASSDGRIRLWQVGAAELGGTGKTPGQVGKLLGMYETQNRITCVEAFVMIPRPLGAEESEYEFESDESEDSDDEEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H734</accession>
    <name>Q2H734_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_05531</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221626.1">
        <property type="nucleotide sequence ID" value="XM_001221625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H734"/>
    <dbReference type="FunCoup" id="Q2H734">
        <property type="interactions" value="1144"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H734"/>
    <dbReference type="GeneID" id="4391330"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05531"/>
    <dbReference type="eggNOG" id="KOG3184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055156_0_2_1"/>
    <dbReference type="InParanoid" id="Q2H734"/>
    <dbReference type="OMA" id="IVEPWIA"/>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="6">
        <location>
            <begin position="14"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="5">
        <location>
            <begin position="90"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ88912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="249" mass="28719" checksum="8063FD8CD6E2C22B" modified="2006-03-21" version="1">MAPTSVPTQNDVLVPETLLKKRKSQEKARAERTAEQDKQKKANKEKRGVIFKRAEKYVKEYRDAEREKIRLNRVAKQDGSFYVPAEAKLIFVIRIKGINKIAPKPRKILQLLRLLQINNGVFIRITKATAEMIKVVEPWVAYGYPNLKSVKELIYKRGYGKVNGQRIPLTDNAIIEENLGKYGIICMEDLIHEIMTVGPNFKQASNFLWPFKLSNPNGGFRTRKFKHFIEGGDLGNREEHINALIRQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H760</accession>
    <name>Q2H760_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221600.1">
        <property type="nucleotide sequence ID" value="XM_001221599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H760"/>
    <dbReference type="GeneID" id="4390236"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05505"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_1_1"/>
    <dbReference type="InParanoid" id="Q2H760"/>
    <dbReference type="OMA" id="CTHIMQP"/>
    <dbReference type="OrthoDB" id="4589250at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="145"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="453" mass="50635" checksum="EA28F8CF67FCBF81" modified="2006-03-21" version="1">MAIEAIGKNKNSQYPGRSQTVQRSRSNDSPPTLRGVEDMANHLLRERDAPPVGKLWAHNFVKRQPQLRTCRTRRYDYQRAKSEDPKIIGQWFTLVQNTRAKYGIVDDDVYNFDETGFMMGIIFAGMVVTTSDGRSKAKLAQPGNREWATVIQGVNALGWAIPPFIILAAQYHLANWYRECNLPLDWRMATTDNGWTTNAVGLDWIKHFDYHTAPRTKGIYRLLILDGHESHHSPEFELYCRDNKIITLCMPAHSSHKCQPLDVGCFGPLKQAYGRLIEELMRAHINHITKLEFLCAFREAFFASMTERNIQGGFAGAGIVPYDPERVLSKLDIKASYTNTPDLTARYCTTLGLQNPTQRPGSQLAVKPLLSLALPAIKTAPQLPMLAAVDQLTKGTTAVMHQVGSPSVRGLPSLRKANEALSKRRRGQKNTCTAWRVTYCTGCTGSTGPEGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7L6</accession>
    <name>Q2H7L6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_05349</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221444.1">
        <property type="nucleotide sequence ID" value="XM_001221443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7L6"/>
    <dbReference type="STRING" id="306901.Q2H7L6"/>
    <dbReference type="GeneID" id="4390483"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05349"/>
    <dbReference type="eggNOG" id="ENOG502SVGD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_918278_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7L6"/>
    <dbReference type="OrthoDB" id="4502329at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209332" description="Transmembrane protein" evidence="3">
        <location>
            <begin position="34"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ88730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="31406" checksum="74184E1C7C66A4BE" modified="2006-03-21" version="1">MGARAGCFAFRPNWDLACLLLLLLQSFNGRTLAQTAASDAPANFQGLYLNPTAPAAIETISCDTSSIFALSSTFAGCCRIGGNCNFPTACTKGTPTNRRGVRWSCGLDRECYTMTVYDALLGRLRELARLQLCQVLGPEPTGSMAMSTGMVTTTTPGGPPAAITSDGGQGGEQPGEAETSSSRAWIAGAVIGGVVGAAGLGALGFLFEKRRGRAAEGEEGGTGFKLHSTTLLRSGGTPAQYPDPTLPGQMGAVYVAGGVEIEGYTPEKGLPTSPQEVSDTGATHAELESTPVWQKQDHGSYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H800</accession>
    <name>Q2H800_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_03654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230170.1">
        <property type="nucleotide sequence ID" value="XM_001230169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H800"/>
    <dbReference type="GeneID" id="4389050"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03654"/>
    <dbReference type="HOGENOM" id="CLU_1805954_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H800"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ91719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="143" mass="16127" checksum="C2887634D57C6405" modified="2006-03-21" version="1">MPLWNDRHLITYLRAELEKEIQRMDDEDPGMGTPIELEFAPMDTKLLPEWLDSATASPPAMNPCPGSSLPVINPPRFILQDTDFVEHGIKGAAIHIYQAQESAIQPNNMTWLCSLVWDNKGFNALNWHSRTTLPASSSLLWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9B5</accession>
    <name>Q2H9B5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229705.1">
        <property type="nucleotide sequence ID" value="XM_001229704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9B5"/>
    <dbReference type="STRING" id="306901.Q2H9B5"/>
    <dbReference type="GeneID" id="4389359"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03189"/>
    <dbReference type="eggNOG" id="ENOG502QUAB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028348_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9B5"/>
    <dbReference type="OrthoDB" id="5865767at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="316" mass="35521" checksum="746BAA1F5652263B" modified="2006-03-21" version="1">MARRPSDAFSQHSVGSDAPSGRPRRMSMEEDMFYRELMTSRPAKPPSYDSAVKAAVAAQRRAQAASGQGIARHITEDVLPQYSCAVHMEGVFMRKMEIEETTKRAEYRDWRMVYVELRGTALNVYSVKKERGWWSSSKHDGPDILPDNPPWVKKSTLEKSYSLLHADAGIAADYRNEGKTGVTKTRTAMRGGGDEPADLDYGGDEDGAAGYGPRTDHPIVGRLSTTSYPNESIDPETGKWKPQHGWSTTHDLLYARLCYSVLLFKSPRKSNYVIARGKRWYVDWGTGRMVRALPPAYGELDVMGPWQVIMPENRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9G4</accession>
    <name>Q2H9G4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_03140</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229656.1">
        <property type="nucleotide sequence ID" value="XM_001229655.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2H9G4">
        <property type="interactions" value="773"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H9G4"/>
    <dbReference type="GeneID" id="4389772"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03140"/>
    <dbReference type="eggNOG" id="KOG1870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001060_9_1_1"/>
    <dbReference type="InParanoid" id="Q2H9G4"/>
    <dbReference type="OMA" id="KPRGCTG"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF24">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUSP" evidence="10">
        <location>
            <begin position="83"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="442"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="714"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="928"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1292"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1406"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1525"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="723"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1012"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1301"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1357"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1425"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1531"/>
            <end position="1543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ91205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1550" mass="169790" checksum="5E8EB3E6A9763807" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9R3</accession>
    <name>Q2H9R3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ADP-ribosylation factor-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_03041</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229557.1">
        <property type="nucleotide sequence ID" value="XM_001229556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9R3"/>
    <dbReference type="FunCoup" id="Q2H9R3">
        <property type="interactions" value="415"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H9R3"/>
    <dbReference type="GeneID" id="4388428"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03041"/>
    <dbReference type="eggNOG" id="KOG0072">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
    <dbReference type="InParanoid" id="Q2H9R3"/>
    <dbReference type="OMA" id="MGAGMSW"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
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        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ91106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="20473" checksum="BD29C2B1EB44FD4C" modified="2006-03-21" version="1">MGQTVSWLSNWVWAKKEIRILILGLDNAGKTTLLYRLKIGEVVTTIPTIGFNVESVTYGKLNFNVWDLGGQTSIRPYWRCYYANTAAVIFVVDSTDIERLQTAADELSAMLNEDELKDAALLVFANKQDQPGAKGAADISQALRLGELRDRNWSIMACSAVEGSGIKEGMDWLSVSLSLVLNLTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9T7</accession>
    <name>Q2H9T7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_03017</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001229532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9T7"/>
    <dbReference type="STRING" id="306901.Q2H9T7"/>
    <dbReference type="GeneID" id="4388599"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03017"/>
    <dbReference type="eggNOG" id="KOG1341">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005947_5_0_1"/>
    <dbReference type="InParanoid" id="Q2H9T7"/>
    <dbReference type="OMA" id="SGPTWIL"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF5">
        <property type="entry name" value="POTASSIUM ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="569"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="213"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="668"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="668"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ91082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="698" mass="77502" checksum="7F82EB5E8E95DD4B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9Y6</accession>
    <name>Q2H9Y6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_02968</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229484.1">
        <property type="nucleotide sequence ID" value="XM_001229483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9Y6"/>
    <dbReference type="STRING" id="306901.Q2H9Y6"/>
    <dbReference type="GeneID" id="4389720"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02968"/>
    <dbReference type="eggNOG" id="KOG1989">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011638_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9Y6"/>
    <dbReference type="OMA" id="MDSHASQ"/>
    <dbReference type="OrthoDB" id="2018507at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14037">
        <property type="entry name" value="STKc_NAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000441">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="270"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="403"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="657"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="425"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="456"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="535"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="613"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="674"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="710"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="728"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="763"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="794"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="845"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ91033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="915" mass="99784" checksum="FD7068A061856B6E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HA02</accession>
    <name>Q2HA02_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229468.1">
        <property type="nucleotide sequence ID" value="XM_001229467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HA02"/>
    <dbReference type="GeneID" id="4389775"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02952"/>
    <dbReference type="eggNOG" id="ENOG502SP43">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090736_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HA02"/>
    <dbReference type="OMA" id="PHFGTLC"/>
    <dbReference type="OrthoDB" id="3890746at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="24033" checksum="6C08B1EA12EB7FE9" modified="2006-03-21" version="1">MEKSSRSQGSASSFEAESQDLHLQSKMRTIRMVDSARAGVTVLALLMGLTVLGVAGNTLRVYESTHVAHEFMLPLWPDHFNLRPTVSLVIGSVIVLVANLIAVCFSHVGALRAKSTLHTTATIIAPMLGLTGALIAVIFYYAVNASEVADTFISWTCRWKDIPMSQAPHWDTLCQQGHAGLYLAILLIPVEVAALALAAFQLKVERYTDRYLGARKTPVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HA16</accession>
    <name>Q2HA16_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_02938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229454.1">
        <property type="nucleotide sequence ID" value="XM_001229453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HA16"/>
    <dbReference type="STRING" id="306901.Q2HA16"/>
    <dbReference type="GeneID" id="4389096"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02938"/>
    <dbReference type="eggNOG" id="ENOG502SMQF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019849_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HA16"/>
    <dbReference type="OMA" id="HWDKETR"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="50539" checksum="B5945F5853DD3BF8" modified="2006-03-21" version="1">MASGRITTFTNTFLVANHEHGGPVLKVVGPQETRKKRPHRCDEGDPCRNCVKRKETCVRLNPVSTSEGVSRHAAVGLSALTRVAWCPLSEPECRPINLLHMELLHHFERYSIPTLPFQEVWPRMLPLAFQGAAHRPPHNAPRDRPAARTRSIPPIPTPPISPPQEPLDLSLDRLYFLSTGVRQIFFMAWPLFQSAQSAFTRAGLLQPCVALEDAVDARGLNWRRWLRAFMEVYDNRRYRGVLGRGGGGNAGCGCGCGYGGGGWCGGSGCGAGFDGAGMGGVSSNPTSYLGGLRNTSLTPTDASPYRIMTLWQSQKEGEMYLQNGGAYDEALVRTAYKRLATRVSIALAFVMDGGNRGGPGSQIGGYGGGGHCQTDVKSSDLVRYVTTFPMMCFGPLLSMISSGDSRMLVLLFHIYRVTGALLPDGRYWWCKKRVEVMGEAIGRELRSRGLEVCLRRQGEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAT9</accession>
    <name>Q2HAT9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_02665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229181.1">
        <property type="nucleotide sequence ID" value="XM_001229180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAT9"/>
    <dbReference type="GeneID" id="4389196"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02665"/>
    <dbReference type="HOGENOM" id="CLU_2687598_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HAT9"/>
    <dbReference type="OrthoDB" id="2112446at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209098" evidence="2">
        <location>
            <begin position="20"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ90730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="74" mass="7898" checksum="87EC0FE99DD06EF1" modified="2006-03-21" version="1">MKGFFFALSVACGIVRAAADPLADFEITPDPGMPSLESVGLSKESCTRCRSRRLPTPGHTSKLAPSLGSNARRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBL3</accession>
    <name>Q2HBL3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228907.1">
        <property type="nucleotide sequence ID" value="XM_001228906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBL3"/>
    <dbReference type="GeneID" id="4389279"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02391"/>
    <dbReference type="HOGENOM" id="CLU_1120048_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HBL3"/>
    <dbReference type="OrthoDB" id="10314812at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="248" mass="27670" checksum="0385EF9819568F3E" modified="2006-03-21" version="1">MASEPKTGGQRLNSAAPISSPIPEIINWPLQKCKMWHGKGHLPPWIEVRRVVSGAIDEGLRTHSLEELVDIVKKPCREAGFKAARNKRDKDAQLEREYHSMVMDFLQRRGLQQSNSSRNAGLSKGVSAGDAKEPTVGTEDPHTDAQEQSYVKVNTPDRPTVDIPQHTGFYANFFNSLFVPSNLQTPVPEADDGLWASEDEWSEVTSQITQGPRRTLGEEKPDDDSEGWVDVKVELDSEEDVAHRWGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBX5</accession>
    <name>Q2HBX5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_02279</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228795.1">
        <property type="nucleotide sequence ID" value="XM_001228794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBX5"/>
    <dbReference type="FunCoup" id="Q2HBX5">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HBX5"/>
    <dbReference type="GeneID" id="4388593"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02279"/>
    <dbReference type="eggNOG" id="KOG1820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008401_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HBX5"/>
    <dbReference type="OMA" id="HNFGCKI"/>
    <dbReference type="OrthoDB" id="205662at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990498">
        <property type="term" value="C:mitotic spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099070">
        <property type="term" value="C:static microtubule bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990571">
        <property type="term" value="P:meiotic centromere clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000019">
        <property type="entry name" value="Cytoskeleton-associated protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048492">
        <property type="entry name" value="Stu2_CTS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="MICROTUBULE ASSOCIATED PROTEIN XMAP215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21042">
        <property type="entry name" value="Stu2_CTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="224"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="180"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="451"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="696"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="472"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="580"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="730"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="783"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="808"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="821"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ90344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="861" mass="93365" checksum="58F01E8F6C2F4F65" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HC01</accession>
    <name>Q2HC01_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_02253</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228769.1">
        <property type="nucleotide sequence ID" value="XM_001228768.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HC01"/>
    <dbReference type="GeneID" id="4388974"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02253"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_1_1"/>
    <dbReference type="InParanoid" id="Q2HC01"/>
    <dbReference type="OMA" id="HYAYNIE"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005720">
        <property type="entry name" value="PRK07538.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="737"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
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            <end position="836"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
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            <end position="860"/>
        </location>
    </feature>
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        <location>
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            <end position="947"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
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            <end position="971"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1371"/>
            <end position="1394"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1414"/>
            <end position="1440"/>
        </location>
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        <location>
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            <end position="1523"/>
        </location>
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        <location>
            <begin position="698"/>
            <end position="983"/>
        </location>
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            <begin position="1029"/>
            <end position="1281"/>
        </location>
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        <location>
            <begin position="1375"/>
            <end position="1651"/>
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        <location>
            <begin position="1692"/>
            <end position="1960"/>
        </location>
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        <location>
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            <end position="512"/>
        </location>
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        <location>
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            <end position="1344"/>
        </location>
    </feature>
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        <location>
            <begin position="1809"/>
            <end position="1851"/>
        </location>
    </feature>
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        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
            <begin position="1822"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ90318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1972" mass="214853" checksum="84437DD010DF1203" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCJ8</accession>
    <name>Q2HCJ8_CHAGB</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="318"/>
        </location>
    </feature>
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        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="209"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="499" mass="54969" checksum="38DA7D5F2C54BA6F" modified="2006-03-21" version="1">MSYSGSFPLGPSPRGRSASRHDDDIFGRPRSWSSRSKSRPRLSEPELSYRPLDPVFGGYSHSRPPSRPRRPSISVAHTGASFVTPGTRDPNYLDPVFSSPASRTSRSPSRYPPSASKSGSLSYTLTGLPVDNRGRSRSRRRSSISLGDAPTTGIFALDLGTDEALGYGPDSRSRRPRPASLERQVHDPFRFRSGTSTSWSGSGEHTSGSLDENPFAPSGISRRPTAPALDQPFKSKFFGSGTSSSGSDPSAARPLEGGSDPSLTGRRRSRSTARSKESSLFGRASGEEDWDLPLPTTSLNRPNARGAPQTRRTSFKSGFSDQMEYDEYSQEHFRPGTDIHNRYNAYSADNLNATDAIITYSEKKAQIPPRKRVTSGPHAAIGDSTNYNLGNTFTIPEHRELRSLAHQSFQHRRAETLGRESFNRDYGRVWEKRALQTGNPNTENHEDVARAMHQNANEWRDIRETHAEALLDLGYPEADLTPYSSWGSHAASRGGSHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCP5</accession>
    <name>Q2HCP5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">CHGG_02009</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ93774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_001221229.1"/>
    </dbReference>
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    <dbReference type="STRING" id="306901.Q2HCP5"/>
    <dbReference type="GeneID" id="4388214"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02009"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021323_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HCP5"/>
    <dbReference type="OMA" id="NCQWLAL"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="56454" checksum="3879D15C9851FBBB" modified="2006-03-21" version="1">MGDIREYSELSEDKTEPFSQGEIQARLQRSRMEEFNTINSAVPLDKLVVPPDDDIRILMRPLARDRTVREDRNVMPLSLRAEAAEAEEKTQQVLAVRQTARDISFTVSIPDYRNPDRRLACIIYYDPASDNQILSNRSNVPFTLSRVSHEPEAIRGAQYQVNPEFHKPLTPGTWRITMGGTDLLDFRLLERRPVRLRTASSSSSETSASSATSTSSGSGSGSGDVVNSSGKRLLDDEDGPINPEKRRRPTDPNDKNENSVIRFLLACAKGKEVVASTGHPLLDLQSVKRSRFHVGGAGCVFTAEYSEAPGRFMAAMLGSCPCIWSPLTAVDLSARGVWRTSGTDLFSGDRSDALRILKDASSGLHYLHSLRLEHNDIKPGNIFVQPGAWGCRLRHGPVIREGRQHGRRHPMISWPDIRAHRQHPRHLYWTIADVHEKERQRQATAVSRMRMWLNEVTAVRNGLDVHDKLERLVHGMLAPNPRERLTTKEIVNQLFVDQGTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCX8</accession>
    <name>Q2HCX8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_01926</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221147.1">
        <property type="nucleotide sequence ID" value="XM_001221146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCX8"/>
    <dbReference type="STRING" id="306901.Q2HCX8"/>
    <dbReference type="GeneID" id="4386476"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01926"/>
    <dbReference type="eggNOG" id="ENOG502RGNJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016357_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCX8"/>
    <dbReference type="OMA" id="WIAPLTE"/>
    <dbReference type="OrthoDB" id="4115389at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056669">
        <property type="entry name" value="DUF7767"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057940">
        <property type="entry name" value="Tri-helical_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF5">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24962">
        <property type="entry name" value="DUF7767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24465">
        <property type="entry name" value="Tri-helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Tri-helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7767" evidence="5">
        <location>
            <begin position="459"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="411"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ93691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="561" mass="62220" checksum="78A521E6122FEEEC" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HD02</accession>
    <name>Q2HD02_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_01902</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221123.1">
        <property type="nucleotide sequence ID" value="XM_001221122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HD02"/>
    <dbReference type="GeneID" id="4387372"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01902"/>
    <dbReference type="eggNOG" id="ENOG502S8A9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012800_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HD02"/>
    <dbReference type="OMA" id="RMWVILY"/>
    <dbReference type="OrthoDB" id="5344325at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF84">
        <property type="entry name" value="FUNGAL SPECIFIC TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="223"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="514"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="536"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="579"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ93667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="782" mass="85956" checksum="FFDC0F1FF05AF038" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HD43</accession>
    <name>Q2HD43_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_01861</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221082.1">
        <property type="nucleotide sequence ID" value="XM_001221081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HD43"/>
    <dbReference type="FunCoup" id="Q2HD43">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HD43"/>
    <dbReference type="GeneID" id="4386390"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01861"/>
    <dbReference type="eggNOG" id="KOG0682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_1"/>
    <dbReference type="InParanoid" id="Q2HD43"/>
    <dbReference type="OMA" id="FNAGSWL"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF4">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="31"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="465"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ93626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="490" mass="52729" checksum="6D94D22262A61497" modified="2006-03-21" version="1">MSTADDSSGNVGTDPTVHDLNAPFNAGDQAYIIVSAAMVLLMVPGIAFLYSGLARRKSALSLIWVTVMSFSVVVFQWYFWGYSLALSNTATNGFIGNLDKFGLRNTLGEPSPGSPLIPELLYSFYQMQFCAVTAALVIGATAERGRVVPAMVFTFFWATLVYCPLAYWAWGANGWAFKYGVLDYAGGGPVEIGSGVSALAYSWVLGRRNEKMMLNFRPHNISLITLGTILLWFGWLGFNGGSAFGANLRATMACWNSCLTAMFAAMTWCLLDYRLAKKWSLVGWCSGTISGLVAATPAAGVITPWASIILGVVAGVACNFGTKIKFMIGIDDAIEVFSEHGIGGIVGLIFNALSAPEYIIGPDGVNMGAAGGWLNHNYRQRYIQVANILAACAYTFFMSAIIVKAIDLVPGLHLRASSEAELLGMDDDPARRVRRDYLAWTPAERDPKEDGVVVVPQHGIAGHQDLAESARLRAPGTGSSSEHHPPHPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HD44</accession>
    <name>Q2HD44_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221081.1">
        <property type="nucleotide sequence ID" value="XM_001221080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HD44"/>
    <dbReference type="STRING" id="306901.Q2HD44"/>
    <dbReference type="GeneID" id="4386376"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01860"/>
    <dbReference type="eggNOG" id="ENOG502S1BG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1686352_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HD44"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="16958" checksum="15DD9324C7C5BBB2" modified="2006-03-21" version="1">MSLTNRLGLGSQDHGESTGLIVAGTAIATTVVLSLLRSYLSPTQPKVIRSPLRSVLPRLSQDEFDKLEYKPDNFPGARDVETPYGSIRVYEWGPLTGEKVVFVHGISTSCITLTKLANALVEEKGCRVMLFDLFGAASPTTPPTCRTTTVCTRLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HD48</accession>
    <name>Q2HD48_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Tricalbin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_01856</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221077.1">
        <property type="nucleotide sequence ID" value="XM_001221076.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2HD48">
        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HD48"/>
    <dbReference type="GeneID" id="4386372"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01856"/>
    <dbReference type="eggNOG" id="KOG1012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001661_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HD48"/>
    <dbReference type="OMA" id="HETIKIN"/>
    <dbReference type="OrthoDB" id="1029639at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04044">
        <property type="entry name" value="C2A_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04045">
        <property type="entry name" value="C2C_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04040">
        <property type="entry name" value="C2D_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21678">
        <property type="entry name" value="SMP_TCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037761">
        <property type="entry name" value="C2A_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037762">
        <property type="entry name" value="C2C_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037756">
        <property type="entry name" value="C2D_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056910">
        <property type="entry name" value="TCB1-3_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017147">
        <property type="entry name" value="Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052455">
        <property type="entry name" value="Tricalbin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980:SF2">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24920">
        <property type="entry name" value="C2_TCB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037232">
        <property type="entry name" value="Tricalbin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="231"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="432"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="575"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="712"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1089"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1327"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="867"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1284"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1460"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="876"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="911"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1284"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1460"/>
            <end position="1469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ93621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1508" mass="166061" checksum="920ED9F55B0EB3D5" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-03" modified="2025-04-09" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDJ0</accession>
    <name>LMBD1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Probable lysosomal cobalamin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">CHGG_01714</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LIMR family. LMBRD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220935.1">
        <property type="nucleotide sequence ID" value="XM_001220934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDJ0"/>
    <dbReference type="STRING" id="306901.Q2HDJ0"/>
    <dbReference type="TCDB" id="9.A.54.1.2">
        <property type="family name" value="the lysosomal cobalamin (b12) transporter (l-b12t) family"/>
    </dbReference>
    <dbReference type="GeneID" id="4386940"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01714"/>
    <dbReference type="eggNOG" id="ENOG502QQ2T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028341_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HDJ0"/>
    <dbReference type="OMA" id="TAERSCW"/>
    <dbReference type="OrthoDB" id="73273at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
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            <end position="646"/>
        </location>
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            <begin position="459"/>
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        <location>
            <begin position="603"/>
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        </location>
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        </location>
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    </feature>
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        <location>
            <begin position="565"/>
            <end position="582"/>
        </location>
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        <location>
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        </location>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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    <sequence length="646" mass="70835" checksum="2594B97FA4B0F38A" modified="2006-03-21" version="1"> </sequence>
</entry>
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                <person name="Untereiner W.A."/>
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        </source>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="104" mass="10747" checksum="D993AE5AA88D6A3C" modified="2006-03-21" version="1">MGLELPSYILAALTATGGAIGYAKTKSKPSLIAGTAVGLLYGLGGYRIDTSAPYGVELSLLASVVLGGSAFPRAIRLRKPVPIVLSLLAAYGLFTFGDAFRRTL</sequence>
</entry>
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                <person name="Untereiner W.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        </cofactor>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
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        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
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        <property type="entry name" value="TYROSINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TYROSINASE"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TYROSINASE_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="22"/>
        </location>
    </feature>
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        </location>
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    </feature>
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    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00498"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ93199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="644" mass="70511" checksum="60E5537CD2EBC0DA" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HF11</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="4">Amidoligase enzyme</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">CHGG_01193</name>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220414.1">
        <property type="nucleotide sequence ID" value="XM_001220413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HF11"/>
    <dbReference type="GeneID" id="4386529"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01193"/>
    <dbReference type="eggNOG" id="ENOG502RIZX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032734_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HF11"/>
    <dbReference type="OrthoDB" id="5291055at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022025">
        <property type="entry name" value="Amidoligase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847:SF1">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12224">
        <property type="entry name" value="Amidoligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="47546" checksum="B987ABA46530BE45" modified="2006-03-21" version="1">MSTSGTRAKKTPPGTGPLPLFGVEIEIYVKLHKDLEEKIRERRYRDPNTMPLYWLEWDFDLQNGQGNLERKAKQRECVGKAVREIIDVTLGTGHGWTCESDASLKEWALTEPPDVRKWWGIEIISPPMSVTKHWQEEIELIFQAVGRHFDFWTNECCACHVHVSPGPTKKHKYTTTQLVRMAKGAFFWEEAFKELLPPERRNNRLGTVELRRQAGVASAMTAIHRILLALTLHVSAFRYDFDGAKNRKTKPDAAELIRELAGCIKKLPGETCHGSRFINFLYWCQESYAGNKCYTEKQINTREKALREGKTPPKQATGPAPPPMNAAPAAGQRASTSTTSLPLRTTTTVRTSQPGAPARSGGGRGGGGGSNNNTTSRTSITRAPTIVSPPLPSRRSDAGRSDAPRAVVASVSGNRTVYEIRQPPERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFL2</accession>
    <name>Q2HFL2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220213.1">
        <property type="nucleotide sequence ID" value="XM_001220212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFL2"/>
    <dbReference type="GeneID" id="4386572"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00992"/>
    <dbReference type="HOGENOM" id="CLU_2573663_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HFL2"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="81" mass="8128" checksum="51B6A2A5AB44CD31" modified="2006-03-21" version="1">MARAAGTRLAALPSFPDPPAAVPSSRKSQNCVPSQDLRARGGSSDLGPAACPRSIWNPPVRPALLAKASSASAPIPATDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFP0</accession>
    <name>Q2HFP0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_00964</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220185.1">
        <property type="nucleotide sequence ID" value="XM_001220184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFP0"/>
    <dbReference type="STRING" id="306901.Q2HFP0"/>
    <dbReference type="GeneID" id="4387280"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00964"/>
    <dbReference type="eggNOG" id="KOG2130">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016785_1_2_1"/>
    <dbReference type="InParanoid" id="Q2HFP0"/>
    <dbReference type="OMA" id="WPAYKNW"/>
    <dbReference type="OrthoDB" id="424465at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF21">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="71"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="3">
        <location>
            <begin position="224"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ92729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="461" mass="51864" checksum="7F89B868E93AA0BE" modified="2006-03-21" version="1">MLPSRQRQSRSCAFEEEGDGSQPLSHPVTVIPNNSQDEPSLGSSVPAHPFGVKPLGNKYFSSGGEDARRSLGVLQILPDEMLMQLLEYLDAHTLRLLGYTCNRLRRNTEYEAEVGRVSGHISLNQYTKNIPAANEIDRFENLSYEEFAGKWSKKPFILTKCIQAWSVTESWTLESLLSQYSDVVFRAEAVDWSFKTYHQYMRNSQDESPLYLFDRKFAEKMSLKVGKEEGAAYQRPDCFGPDYFELLGAERPAHRWLIIGPARSGSTFHKDPNATSAWNAVIQGAKYWIMFPPSASVPGVFVSKDSSEVTSPLSIAEWLLEFHSEARKLPECREGICQAGEILHVPSGWWHLVVNLEDGIALTQNFVPETHLGGVMSFLKDKADQVSGFESEVADPYGLFISRLKEERPDLLEAGLRQLAEKKRRWDSVVGDDESSGDQPQKKNTGFSFGFGFGDEDDEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFP4</accession>
    <name>Q2HFP4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apurinic-apyrimidinic endonuclease 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_00960</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220181.1">
        <property type="nucleotide sequence ID" value="XM_001220180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFP4"/>
    <dbReference type="FunCoup" id="Q2HFP4">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HFP4"/>
    <dbReference type="GeneID" id="4387323"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00960"/>
    <dbReference type="eggNOG" id="KOG3997">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025885_1_2_1"/>
    <dbReference type="InParanoid" id="Q2HFP4"/>
    <dbReference type="OMA" id="DEGCQSH"/>
    <dbReference type="OrthoDB" id="7663182at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000001">
        <property type="entry name" value="Probable endonuclease 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002199">
        <property type="entry name" value="PRK01060.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="10">
        <location>
            <begin position="132"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="415"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ92725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="470" mass="50870" checksum="25B02D9369022F0A" modified="2006-03-21" version="1">MARQSARKVAQAKTTTIEPKTRIEKAAGASGASVTTKSTKVTIVTETKVEVTETRAPKRKTTPTEPEFDGEDLENASPVEDKKPAPKKRKTTKKDAENTMALAARTAVTSLKRAMYIGAHVSAAGGVQNSIQNATHIGANAFALFLKSQRKWVSPPLADEAKTQFHDLLKQHSYDAGKHIVPHGSYLVNLAQADKTKATQAYDGFLDDLQRCEALGITLYNFHPGSTGGAAMSEACARIAGQLNRAHKATKTVVTLLENMCGSGNVVGSRFEELRDIIALVDDKARVGVCIDTCHAFAAGYDLRTPAAFDKTMAEFDAVVGLKYLRALHINDSKAPFGSHRDLHANIGTGCLGLRAFHNVMNHEKLQGLPMVLETPIDEKGPDGKTVENKQIWADEIKLLESLIGMDVDSAEFKEKEKELNAQGASERQKIQEQVDKKAGKGAKQGTKGKARGKKTKKEEESCDSCGESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFU7</accession>
    <name>Q2HFU7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_00907</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220128.1">
        <property type="nucleotide sequence ID" value="XM_001220127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFU7"/>
    <dbReference type="FunCoup" id="Q2HFU7">
        <property type="interactions" value="1376"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HFU7"/>
    <dbReference type="GeneID" id="4386385"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00907"/>
    <dbReference type="eggNOG" id="KOG2920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038704_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HFU7"/>
    <dbReference type="OMA" id="NLLLTWH"/>
    <dbReference type="OrthoDB" id="1723750at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ92672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="372" mass="39920" checksum="DB283F634666CE57" modified="2006-03-21" version="1">MAFSFSFAGDDIEEDHQAPAPPPPSPPSGNSASGPSPATAGAFPVQGKPLLPPTQHNPEEFLSKLPSKIAFGLLDVDLGDGRVIQLPRRELWDVRVQLMAEENTENPSESEAALGEHDVKTGIYEGGFKSWESSVDLVKVLASERAADLLAQDPCVLIELGCGTALPSLALFQWALTERKSEQNQPLMLALADYNPTVLSLVTLPNLVLAWALQQRNENAVLNEAFTPDGELELTPEVLEAFKQSLSSKQITLSFLSGAWSSEFVDLLYRSGVPANLPATTKTLLLGSETIYSPFALESFGSTLLSILQRERAERSSGGGARALVAAKRLYFGVGGSLDDFVDKMRGLGASVKTLSEETQGVHRGVVECLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG11</accession>
    <name>Q2HG11_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 13">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="10 13">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_00843</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10 13">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10 13">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 13">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="10 13"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220064.1">
        <property type="nucleotide sequence ID" value="XM_001220063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG11"/>
    <dbReference type="FunCoup" id="Q2HG11">
        <property type="interactions" value="836"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HG11"/>
    <dbReference type="GeneID" id="4387989"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00843"/>
    <dbReference type="eggNOG" id="KOG2653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024540_4_2_1"/>
    <dbReference type="InParanoid" id="Q2HG11"/>
    <dbReference type="OMA" id="CVTHVGP"/>
    <dbReference type="OrthoDB" id="434986at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.320:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000007">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006765">
        <property type="entry name" value="PRK09287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5 10 13" id="KW-0521">NADP</keyword>
    <keyword evidence="6 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 10 13" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="183"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="133"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="190"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ92608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="494" mass="54414" checksum="579AE467C47834EB" modified="2006-03-21" version="1">MSGAVPGAPGMRLIIVRRGQNLIMNMADHGYTVCAFNRTVSKVDVFLANEAKGKSIVGAHSVEEFVSKLKRPRRVMLLVQAGKPVDDWIETLLPLLEAGDIIIDGGNSHFPDSNRRTKYLASKGLRFVGSGVSGGEEGARYGPSLMPGGHEDAWPHIKGIFQSIAAKSDGEDCCDWVGDEGAGHYVKMVHNGIEYGDMQLICEAYDIMKRGLGMSCKEIGDVFAKWNKGVLDSFLIEITRDILYYNDEDGTPLVEKILDKAGQKGTGKWTAVNALDLGMPVTLIAEAVLARCLSGIKEERVKASGKLEFVGRVNTFEGNKEQFLDDLEQALYASKIISYAQGFMLMQEAAREYGWKLNKPSIALMWRGGCIIRSVFLQDITAAYRKNPDLENLLFDDFFNKAIHKAQPGWRDVVAKTALLGIPSPAFSTALSWFDGYRTKDLPANLLQAQRDYFGAHTFRIKPEAANAKYQEGKDIHVNWTGRGGNVAASTYQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG61</accession>
    <name>Q2HG61_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TRM5</name>
        <name evidence="12" type="ORF">CHGG_00793</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="9">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="9"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220014.1">
        <property type="nucleotide sequence ID" value="XM_001220013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG61"/>
    <dbReference type="FunCoup" id="Q2HG61">
        <property type="interactions" value="976"/>
    </dbReference>
    <dbReference type="GeneID" id="4386844"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00793"/>
    <dbReference type="eggNOG" id="KOG2078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022610_2_2_1"/>
    <dbReference type="InParanoid" id="Q2HG61"/>
    <dbReference type="OMA" id="DFRSVYW"/>
    <dbReference type="OrthoDB" id="408788at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070901">
        <property type="term" value="P:mitochondrial tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF36">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="11">
        <location>
            <begin position="162"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="348"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="710"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="718"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="319"/>
            <end position="320"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ92558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="734" mass="80251" checksum="541A2C65837F785E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-24" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH63</accession>
    <name>SEC24_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Protein transport protein SEC24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SEC24</name>
        <name type="ORF">CHGG_00441</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219662.1">
        <property type="nucleotide sequence ID" value="XM_001219661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH63"/>
    <dbReference type="SMR" id="Q2HH63"/>
    <dbReference type="FunCoup" id="Q2HH63">
        <property type="interactions" value="783"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HH63"/>
    <dbReference type="GeneID" id="4388273"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00441"/>
    <dbReference type="eggNOG" id="KOG1985">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004589_2_1_1"/>
    <dbReference type="InParanoid" id="Q2HH63"/>
    <dbReference type="OMA" id="AVECSKQ"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990753">
        <property type="term" value="C:equatorial cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01479">
        <property type="entry name" value="Sec24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041742">
        <property type="entry name" value="Sec24-like_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0931">ER-Golgi transport</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000295484" description="Protein transport protein SEC24">
        <location>
            <begin position="1"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Zinc finger-like">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="947" mass="103085" checksum="9BD39F23320BF413" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHM3</accession>
    <name>Q2HHM3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219502.1">
        <property type="nucleotide sequence ID" value="XM_001219501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHM3"/>
    <dbReference type="GeneID" id="4387955"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00281"/>
    <dbReference type="HOGENOM" id="CLU_1250522_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHM3"/>
    <dbReference type="OrthoDB" id="3431997at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="221" mass="23104" checksum="751CEB1914FBBEA6" modified="2006-03-21" version="1">MGHSHSQPTPLTLPPSLTNNHPLPTRISAAYQKSWTKITILLHDASTPTNNPTTPTYTITLPQGWYGAMTMHATNPNNPDPDSATPLAKADPAGRMRQDFAVGLPALGKGGVQRAEVLRYVVGWRHEVYWFAMAVGGGGGSSAGVERFEWRRSRGGEVKGVEGGSGWGWKLVRVGGSGGSGGQGNGYGGDEGGGWVDERWEGGGGGVGESGDAEFFEAGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHR2</accession>
    <name>Q2HHR2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_00242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219463.1">
        <property type="nucleotide sequence ID" value="XM_001219462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHR2"/>
    <dbReference type="GeneID" id="4387178"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00242"/>
    <dbReference type="eggNOG" id="ENOG502STA4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_700393_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHR2"/>
    <dbReference type="OMA" id="DMPRTEA"/>
    <dbReference type="OrthoDB" id="4576518at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ92007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="363" mass="39532" checksum="4336A59C4D74F57F" modified="2006-03-21" version="1">MNGCRQAGEKCVYLPTCRPNKADLAQKLDTLQQRLGRFLQLQVAPVGAHIMMMSGTNGGNERDVNAAGTVTEKAEAYIRKMDNEANCTKTAVPSYFSPPPTMSPASTPRLPLQMPPFGTPPTPTSFTPGLYHPEPRIKWPELLGNDFLYTPLLDSQMQAGGMDGTQLDGHVDGTDLSEHARSSSSISIPSLREIRELSSALYTTDRVARVCDTCNAATAELEAYCMTAFSAHSDIAGISLALAEYLAWMRKGANLKTDNIASMLETLEFRAREVHEIAEARPWAAWRNMVLALKPLGRAATRLAELEEDLGRQSAEAGHFFQTEYDIRMTLADQRKSPVMGVGMELGTPLAASSDASGSQMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHX8</accession>
    <name>Q2HHX8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CHGG_00176</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219397.1">
        <property type="nucleotide sequence ID" value="XM_001219396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHX8"/>
    <dbReference type="FunCoup" id="Q2HHX8">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="GeneID" id="4387612"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00176"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1911">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_303037_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHX8"/>
    <dbReference type="OMA" id="DFHHPDE"/>
    <dbReference type="OrthoDB" id="1918685at2759"/>
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        <source>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="983" mass="111436" checksum="EFDA4EC5B230FE64" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI49</accession>
    <name>Q2HI49_CHAGB</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00105</name>
    </gene>
    <organism evidence="3 4">
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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        <location>
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            <end position="270"/>
        </location>
    </feature>
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        <location>
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            <end position="320"/>
        </location>
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        </location>
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            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="356" mass="40555" checksum="1DF856AC2037F250" modified="2006-03-21" version="1">MAENTRRATPPLDLLTQELEPKRLHRRMRFLWLAGRPVPPRPLHHQLLLGREIFVSERIDLHLVWGGGRIFIKPLPRYLMNPDFWRGHLTCRCHHHHHHHASRGPEKTTATKQPETTLERELSETGALCSPQESSGSGGGDMGPLCDRRRLRQCAMGFLLGYVALVAHESDFRIAAEKGLIPSQVTWSCWRKFVREVLHKSQENMWSDVAERFIYGELRLNRLNLIEVVLRGPFSRGYLATWTSFGSFYRYSSALIIAGTAYILLILSAMQVGLGTTKLAEDDTFQAASYGFAVFSILGPMGAVLAFMIVFAMTLIYNMLRTRRFEARRARRLGRSWGSKHQAHEDGHATAKPSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM10</accession>
    <name>Q2GM10_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ83176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001226260.1"/>
    </dbReference>
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    <dbReference type="STRING" id="306901.Q2GM10"/>
    <dbReference type="GeneID" id="4397141"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10994"/>
    <dbReference type="eggNOG" id="ENOG502S9TE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_295598_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GM10"/>
    <dbReference type="OMA" id="KCASEER"/>
    <dbReference type="OrthoDB" id="3594103at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
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            <begin position="94"/>
            <end position="116"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
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        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
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        <location>
            <begin position="126"/>
            <end position="157"/>
        </location>
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        <location>
            <begin position="342"/>
            <end position="428"/>
        </location>
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            <begin position="671"/>
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        </location>
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            <begin position="12"/>
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            <end position="388"/>
        </location>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1023" mass="111064" checksum="C0586EA9C3DE1224" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM88</accession>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="EAQ83098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="12722" checksum="7E3FBA5BB4C96B6D" modified="2006-03-21" version="1">MQFADARYPHMFAVGDIADSGAHKAAKPGMAQAAVAARNIASMVAGREATEEMSLSPAGIHLTLGLTRNVIFRNPNIAAGDTEPYIELKDDGREDMNIERVWTIRGITVKSPQDYHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
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        </lineage>
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
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        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
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    </dbReference>
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        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EP450I"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
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    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
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        <location>
            <begin position="470"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="489"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="523"/>
        </location>
        <ligand>
            <name>heme</name>
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        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ83076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="65891" checksum="8227B56FB36C5806" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMG4</accession>
    <name>Q2GMG4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase kappa</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">CHGG_10840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226107.1">
        <property type="nucleotide sequence ID" value="XM_001226106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMG4"/>
    <dbReference type="STRING" id="306901.Q2GMG4"/>
    <dbReference type="GeneID" id="4397316"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10840"/>
    <dbReference type="eggNOG" id="KOG2094">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012348_11_2_1"/>
    <dbReference type="InParanoid" id="Q2GMG4"/>
    <dbReference type="OMA" id="EVYTRQV"/>
    <dbReference type="OrthoDB" id="1747274at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.810:FF:000001">
        <property type="entry name" value="DNA polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000014">
        <property type="entry name" value="DNA polymerase kappa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000010">
        <property type="entry name" value="DNA-directed polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative DNA-directed polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050116">
        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002677">
        <property type="entry name" value="PRK02406.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076:SF33">
        <property type="entry name" value="DNA POLYMERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076">
        <property type="entry name" value="DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="5">
        <location>
            <begin position="126"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="474"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="586"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="598"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ83022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="632" mass="70780" checksum="392BAC189D2E24EA" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMN9</accession>
    <name>Q2GMN9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ82947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226032.1">
        <property type="nucleotide sequence ID" value="XM_001226031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMN9"/>
    <dbReference type="STRING" id="306901.Q2GMN9"/>
    <dbReference type="GeneID" id="4397257"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10765"/>
    <dbReference type="eggNOG" id="ENOG502S1W1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006713_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GMN9"/>
    <dbReference type="OMA" id="DASTIMA"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="9"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4470" evidence="2">
        <location>
            <begin position="166"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ82947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="758" mass="85036" checksum="251E654EA4A4FFBB" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNN0</accession>
    <name>Q2GNN0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_10424</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <topology evidence="1 9">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228351.1">
        <property type="nucleotide sequence ID" value="XM_001228350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNN0"/>
    <dbReference type="FunCoup" id="Q2GNN0">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GNN0"/>
    <dbReference type="GeneID" id="4396089"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10424"/>
    <dbReference type="eggNOG" id="ENOG502QRZZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021855_1_2_1"/>
    <dbReference type="InParanoid" id="Q2GNN0"/>
    <dbReference type="OMA" id="HDKCMTI"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000032">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF4">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005142901" description="1,3-beta-glucanosyltransferase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="413"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ84020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="488" mass="52309" checksum="7AEC519A6191FCF2" modified="2006-03-21" version="1">MQLHSALVALGATVVAAVQPLEVKGRDFINPTTGNRFQIVGVAYQPGGSAGYDKEAGRDPLSDPDICMRDAALLQILGVNTIRVYNVNPDVNHDKCASIFNAAGMYMVLDVNSPLVGDSLTSWNPWESYYAAYLNRTFAVVEAFKDYPNTLAFFSGNEVLNNEDTGATVPPYMRAVTRDIKNYVKKHVKRPIPVGYSAADVRSILFDTYNYFQCSLDGDDGDMSMGDIFALNSYSWCGESSFEKAKYDQLVSGLKGATVPVFFSEYGCNTPSPRVFTEVGTIYSSKMSDVFSGGVVYEYTQEDNNYGLVDMKTDGSAKLRSDFVSLKNQYSKLDFAEIQGQKPATTSNGKPPACETKLITTKGFNSNFTLPVLPPGAQEIIDNGVKPTPKGKLVKITDWKVKYTVKNPDGSTITNLSVKPLADDDINSPGSNTDSGTDTSTAGTQTSDASTDGTKTDAPTPSDNAAAGSVAAVLPAAVLGAFAVLAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GP22</accession>
    <name>Q2GP22_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228209.1">
        <property type="nucleotide sequence ID" value="XM_001228208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GP22"/>
    <dbReference type="GeneID" id="4396169"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10282"/>
    <dbReference type="HOGENOM" id="CLU_1266736_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GP22"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="218" mass="23711" checksum="426B2AF189A7C2A4" modified="2006-03-21" version="1">MAFCRRTQYAPEPDSSAGTISITVYRRVPCMTWGTQISVGAVGFCRRWGCGRCHVAEEWVCGGFAASDSATSRPSACGWLVKSRNNGLGIPYETHGAGVAIAVNPVGAVVGIEVLAPVLVKSAAAPTWEADEVEEDGEMLLYTRGGQDPRRSLSPWVREPGYLRPATSKLLRRVTCYERTTFSRVHGSHLRGSLTRLVDPRCENEQPNRNPSETGGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GP58</accession>
    <name>Q2GP58_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RuvB-like helicase</fullName>
            <ecNumber evidence="16">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_10246</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="function">
        <text evidence="15">DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="16"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228173.1">
        <property type="nucleotide sequence ID" value="XM_001228172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GP58"/>
    <dbReference type="FunCoup" id="Q2GP58">
        <property type="interactions" value="1264"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GP58"/>
    <dbReference type="GeneID" id="4396867"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10246"/>
    <dbReference type="eggNOG" id="KOG2680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028311_4_0_1"/>
    <dbReference type="InParanoid" id="Q2GP58"/>
    <dbReference type="OMA" id="IINTEPY"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002221">
        <property type="entry name" value="RuvB-like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000002">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="67"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00055509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ83842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="471" mass="51432" checksum="3FA702CE7D66C4AA" modified="2006-03-21" version="1">MQPVVTISESKELRGLNLIAAHSHIRGLGVDADTLEPRTASQGLVGQEKARKAAAVILEMIKQGKIAGRAVLIAGPPSTGKTAIAMGMAQSLGPDVPFTTLAASEIFSLEMSKTEALTQAFRKSIGVRIKEESEIMEGEVVEIQIDRSVTGGAKQGKLTIKTTDMEAIYDMGSKMIDAMTKERVMAGDIISIDKSSGKITKLGRSYARSRDYDAMGVDTKFLQCPDGELQKRKEVVHTVSLHEIDVINSRTQGFLALFSGDTGEIRSEIRDQINTKVAEWKEEGKAEIVPGVLFIDEVHMLDIECFSYVNRALESDLAPIVIMASNRGHSRIRGTDYKSPHGLPLDFLDRVAIINTHSYTGDELRQILSIRAQEEEVDLTPDALALLTKIGQEAGLRYASNLITTSQLICAKRRAKQVVVEDVQRSFKLFYDPARSVGFVAESEKRLIGDDGVVDFVVKSNGTAGETMDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GP99</accession>
    <name>Q2GP99_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228132.1">
        <property type="nucleotide sequence ID" value="XM_001228131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GP99"/>
    <dbReference type="GeneID" id="4396388"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10205"/>
    <dbReference type="eggNOG" id="ENOG502T1TD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015630_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GP99"/>
    <dbReference type="OMA" id="HHRGAKN"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053083">
        <property type="entry name" value="TF_kinase-domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44305">
        <property type="entry name" value="SI:DKEY-192D15.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44305:SF24">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE C03B1.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
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        </source>
    </evidence>
    <sequence length="244" mass="27898" checksum="4E7B06F0322A523D" modified="2006-03-21" version="1">MHPSESPHEDRYQSQDDNKPPSRTAYLLALCLLPLLTTSLALWAVLNAWHLQLSPNIPHQPRAQHHQPLPTHPHRWTTCGTTPATARARNCRFDILSFAWQTPECYDGELMTAFLQHHPWQFYAHPNRTDAVVSLEVALQGEQTLYVDWAYHIAHCTFMWRQMHRAYRLRGFVDSHLDAYAHTLHCQRVLLERGVPGGRVNVVAAVKYPECREVGGRGWKLEGENFSGEGGHNGIEPCSRERSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQ12</accession>
    <name>Q2GQ12_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227869.1">
        <property type="nucleotide sequence ID" value="XM_001227868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQ12"/>
    <dbReference type="STRING" id="306901.Q2GQ12"/>
    <dbReference type="GeneID" id="4396675"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09942"/>
    <dbReference type="eggNOG" id="ENOG502S5EQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1120773_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQ12"/>
    <dbReference type="OMA" id="PHRHDIL"/>
    <dbReference type="OrthoDB" id="2590867at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39606:SF1">
        <property type="entry name" value="CELL SURFACE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39606">
        <property type="entry name" value="SURFACE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="251" mass="25229" checksum="BB6BE40F1B8DE39C" modified="2006-03-21" version="1">MYHNTTPQERGIRNPNAPTAAPPGGLTYGQSPTSGPAPTTAGHHKHDIINKLDPRIDSTHDRQPMPQTRNNKIPEGTYGPHSSRLANALDPRVDSDLDSTTRTGAGTGMHGTAAGAGAGYAPHGTAQAAEGTYGPHHTRMANAADPRVDSDRDRHHLGTTGAHSGGGGGGIMSGGPAAAPYQGGGTHAGMVPGHAGAGVGAAAPHNTATTTTTTSAGPHKSGLLNKLDPRVDSKTGMYKDTAGAGTRGGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQ38</accession>
    <name>Q2GQ38_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_09916</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227843.1">
        <property type="nucleotide sequence ID" value="XM_001227842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQ38"/>
    <dbReference type="STRING" id="306901.Q2GQ38"/>
    <dbReference type="GeneID" id="4396498"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09916"/>
    <dbReference type="eggNOG" id="ENOG502QUDW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010539_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GQ38"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF3">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ83512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="586" mass="62654" checksum="B703564181AD20AF" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQH8</accession>
    <name>Q2GQH8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_09776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227703.1">
        <property type="nucleotide sequence ID" value="XM_001227702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQH8"/>
    <dbReference type="GeneID" id="4396651"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09776"/>
    <dbReference type="HOGENOM" id="CLU_2704596_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQH8"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ83372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="73" mass="8129" checksum="12A65C02C514DB11" modified="2006-03-21" version="1">MMVRICIRVIREVGLQEMNKAVNVMRAEMAPELPSLLQVRDVRVGDCCVGQSQNTMEEKGQEDSVSALCEATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQJ3</accession>
    <name>Q2GQJ3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_09761</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227688.1">
        <property type="nucleotide sequence ID" value="XM_001227687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQJ3"/>
    <dbReference type="FunCoup" id="Q2GQJ3">
        <property type="interactions" value="861"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GQJ3"/>
    <dbReference type="GeneID" id="4396332"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09761"/>
    <dbReference type="eggNOG" id="KOG0217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GQJ3"/>
    <dbReference type="OMA" id="TPMMAQY"/>
    <dbReference type="OrthoDB" id="10252754at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032137">
        <property type="term" value="F:guanine/thymine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032138">
        <property type="term" value="F:single base insertion or deletion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043570">
        <property type="term" value="P:maintenance of DNA repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000019">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000006">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000771">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 9 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="13">
        <location>
            <begin position="1059"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="795"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="180"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ83357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1221" mass="135480" checksum="652D3C72D6E5F5ED" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQN9</accession>
    <name>Q2GQN9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227642.1">
        <property type="nucleotide sequence ID" value="XM_001227641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQN9"/>
    <dbReference type="GeneID" id="4396635"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09715"/>
    <dbReference type="eggNOG" id="ENOG502SEVM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_193992_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQN9"/>
    <dbReference type="OMA" id="QWSAWKG"/>
    <dbReference type="OrthoDB" id="3360421at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="83" mass="9030" checksum="0263FF2FA55294E4" modified="2006-03-21" version="1">MPSSKGIPTDPELREHLKEEIQQEPNKSGDGKGQWAAWKGMKLAREYEAHGGSYENEPGSKNEPQTGAPVAKGESKKHEESAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GR20</accession>
    <name>Q2GR20_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_09584</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227511.1">
        <property type="nucleotide sequence ID" value="XM_001227510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GR20"/>
    <dbReference type="GeneID" id="4396985"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09584"/>
    <dbReference type="eggNOG" id="ENOG502S03T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_585259_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GR20"/>
    <dbReference type="OrthoDB" id="4436466at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051122">
        <property type="entry name" value="SDR_DHRS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057571">
        <property type="entry name" value="SDR_PhqE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477:SF1">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23441">
        <property type="entry name" value="SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ83180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="50039" checksum="A2263E5A5BAFD962" modified="2006-03-21" version="1">MGIIKKVTLTTLGLGTGVLGYLGASTSIVSPIPEDDPLWRSKSYTKYNSHRNPSTQDVCIKRIPLTKIKPELLEREGDLALEFCRGVWAGLGYRFQRAYLARKYHGPATASQLWTVNQLARSAYEPGTQLTDHFEVVEKTPSEVVVRCGDSPRNPNPRDSDGLFSIGAAVDRERGEAVLKLTSCLFISNNKVEGIQGPMPGWMEMLHRWYARLWMETGSWRKQGLNSQASGVLCGRTQQNSGIPENTSTQCDTDSLNCQCLPQPTAQVSFLTSPILNMPSISGHNLLIIGGSAGIGAAVAKLAAADGVNVAIASSNPDRIEKTIKAIKDALPMKAINISGFVCDVSHNDAEDRLEKLLTDVTAALGDKPIKGLAILAGWATALTGFARSLAVEIAPIRVNLVSPGSTDTDHHGPPEVRIPKMAAVAKASLLGKVGTAEDVAEAYIYLMKDSNCTGSTVSTEGGSLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRU2</accession>
    <name>Q2GRU2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227239.1">
        <property type="nucleotide sequence ID" value="XM_001227238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRU2"/>
    <dbReference type="STRING" id="306901.Q2GRU2"/>
    <dbReference type="GeneID" id="4394826"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09312"/>
    <dbReference type="HOGENOM" id="CLU_1384009_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRU2"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012135814" description="Amidase domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="21298" checksum="6EA2AAD09580BADF" modified="2006-03-21" version="1">MDFWLYFLLLPLALAAIFSWLSGDSHAPKSIPAAFDLLTLTAQDVAQLLSNQTFTSLQLTLEYLRRIELDDRSGLGLHTMLELAPVGTTLAIARERDLERQGGILRSPLHNVPLIIKACPQSSSNTLVIGKANLGGLNGCKYVGPGICTMIGILANQQCPTLGTIISVQPGLGSVAEHCHPTIYSTLADRQLDRPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GS98</accession>
    <name>Q2GS98_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TFIIE beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_09156</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227083.1">
        <property type="nucleotide sequence ID" value="XM_001227082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GS98"/>
    <dbReference type="FunCoup" id="Q2GS98">
        <property type="interactions" value="425"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GS98"/>
    <dbReference type="GeneID" id="4395366"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09156"/>
    <dbReference type="eggNOG" id="KOG3095">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056580_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GS98"/>
    <dbReference type="OMA" id="ISRSHDS"/>
    <dbReference type="OrthoDB" id="5323195at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001097">
        <property type="term" value="F:TFIIH-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040501">
        <property type="entry name" value="TFA2_Winged_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016656">
        <property type="entry name" value="TFIIE-bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003166">
        <property type="entry name" value="TFIIE_bsu_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18121">
        <property type="entry name" value="TFA2_Winged_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51351">
        <property type="entry name" value="TFIIE_BETA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIE beta" evidence="8">
        <location>
            <begin position="176"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="117"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="357"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ85142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="406" mass="44535" checksum="4CE119B77ADA19CB" modified="2006-03-21" version="1">MFTISNRIFILSIIRNQSIWLQYVIPCIEPCKRHPCHCAAANWNSANGPATGPLIFAGATKQPSTPPSAPPAVQRQRDSLLPTKGNKSWMNADNMSNGFDRQHASFLSSMSAAASKLGSGAGTKRSLAPPSPSPSVGSTTSVAAGAGSLTPRKDRHDTPSSSSNAANSSIVYSQPALTGTGDSIISQMAYAVTWLRQKGDPQSCVDVLGYLSATARPEKEQEFFVDQMRRHPQIQWIPDPALSEQTWRSGTYVHRPAIPDVRTKTQLLAYLQKKTDASGVSVKDLKDGWPECEAAITELESEHKVLVVRAKKDGAAKMVWLDDSSLFHEVEPQLKLLWARVELPSIENIVPKLVAAQQKPASEDPRIKASQAPKQDKKKKRVQRKSGKSTNTHMEHLLKDYSHMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSB0</accession>
    <name>Q2GSB0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_09144</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227071.1">
        <property type="nucleotide sequence ID" value="XM_001227070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSB0"/>
    <dbReference type="STRING" id="306901.Q2GSB0"/>
    <dbReference type="GeneID" id="4395766"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09144"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076142_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSB0"/>
    <dbReference type="OMA" id="CDMLDRV"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF16">
        <property type="entry name" value="RING_U-BOX SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="137"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ85130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="211" mass="23598" checksum="397D6E251E301B06" modified="2006-03-21" version="1">MATQYEIEHNIKAAPATSHRRRQVDMSTFTAHLHNLLPDSTPSTTTQSSSHEQQHNNPHAVPNPADTSALFRLLQDQMGTLATTAPNETNRAFLESLVETLELDVAHPPQQIEGVTQEVLDGLDRVPRKTLKDDDTCPICAERYLDDPYCLVVELPCHGSHRFDLECVGPWLRGKGTCPMCRKEVGKRKAVVVEPAEEEEEEEDDMDGLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSF0</accession>
    <name>Q2GSF0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227031.1">
        <property type="nucleotide sequence ID" value="XM_001227030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSF0"/>
    <dbReference type="GeneID" id="4395158"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09104"/>
    <dbReference type="HOGENOM" id="CLU_852586_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSF0"/>
    <dbReference type="OrthoDB" id="10279050at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="326" mass="35194" checksum="35503C519465DC86" modified="2006-03-21" version="1">MAKPQCSRLAHSSHPRAISAQDAAAGFGEQLAGGCLQACQAQSRLVRRHWQAEFTQESRRDEETDSAGVGPCTRTAQVCGGSGKLTAKSSRSRGWSPEVELTMTKPASRQDGLPVVEHESWTPPIRLLNRKPPVGTAKHGKNPQSHDGRGMYGCKPSVRNARIADVCDLFLGSRRRSAQVHCTVVGARGRRLSMDGEAFPGPVLSSERMLRLKRDRPSSGRWGKTVPLACLMLPGGEKPGQFGKVLAAPVLSVQIAPIDRRRVDADAGEPAVPWNGRTRQGINTHNDAAVPPSAVEVETKDGRPALLLHATFPCRLGARQFRFADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSU1</accession>
    <name>Q2GSU1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicotinamide N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_08963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226890.1">
        <property type="nucleotide sequence ID" value="XM_001226889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSU1"/>
    <dbReference type="FunCoup" id="Q2GSU1">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GSU1"/>
    <dbReference type="GeneID" id="4395892"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08963"/>
    <dbReference type="eggNOG" id="KOG2920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032409_0_2_1"/>
    <dbReference type="InParanoid" id="Q2GSU1"/>
    <dbReference type="OMA" id="VGHNPLW"/>
    <dbReference type="OrthoDB" id="46564at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="21675" checksum="FF00F2E8FA087DB5" modified="2006-03-21" version="1">MGPGAGLPSNVGACLGARRVVVTDISDPDLLETMWRNVRGCELLPRSGGRRGIKSCPLWRRGWVWGADPGRVLGYLGEGERGEGFDVLVLADLLFPAFGAQEICCATVRQTLKKSKESKAFVVFTSYRPWLQHKDLAFFDVAREEGWVVEKVLEKKMDRPLFEKDPGDEEILKTVTGWELRWPEEALEEGDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSV9</accession>
    <name>Q2GSV9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_08945</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226872.1">
        <property type="nucleotide sequence ID" value="XM_001226871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSV9"/>
    <dbReference type="FunCoup" id="Q2GSV9">
        <property type="interactions" value="1002"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GSV9"/>
    <dbReference type="GeneID" id="4394893"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08945"/>
    <dbReference type="eggNOG" id="KOG3166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055193_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GSV9"/>
    <dbReference type="OMA" id="RMVKWPA"/>
    <dbReference type="OrthoDB" id="29563at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="122"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ84931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="263" mass="29541" checksum="79BADED86CADEB3F" modified="2006-03-21" version="1">MPPTKSGKKAAPAPFPQGKAGSKKAPKNPLLEKRPRNFGIGQAIQPKRNLSRMVKWPEYVRLQRQKKILNMRLKVPPAIAQFQQVLDKNTAAQAFKLLNKYRPETKTDKKERLLKEATAIKEGKKKEDVSKKPYVVKYGLNHVVGLIENKKASLVLIPNDVDPIELVIFLPALCRKMGIPYAIIKGKARLGTVVHKKTAAVLAITEVRSEDKNELSKLVSAIKEGYVEKHEDARKKWGGGIMGYKAQKRIEKRQKAIETAVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GT32</accession>
    <name>Q2GT32_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_08872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226799.1">
        <property type="nucleotide sequence ID" value="XM_001226798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GT32"/>
    <dbReference type="GeneID" id="4395632"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08872"/>
    <dbReference type="HOGENOM" id="CLU_2222969_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GT32"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="106" mass="12173" checksum="8D6D3CC326AEFA83" modified="2006-03-21" version="1">METEPSIDPLLPPMPFILFPPTAVNKLNNLEDAIAGRATPSTISASTPSRPIQMWLSSWFSSWAERRAERREARLMSRIMVVVLVLLWETRKRWVKVRVRVMAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTL0</accession>
    <name>Q2GTL0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_08694</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226621.1">
        <property type="nucleotide sequence ID" value="XM_001226620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTL0"/>
    <dbReference type="GeneID" id="4394977"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08694"/>
    <dbReference type="eggNOG" id="ENOG502SXT7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_727622_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTL0"/>
    <dbReference type="OMA" id="MANHATM"/>
    <dbReference type="OrthoDB" id="2687452at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="248"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ84680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="380" mass="42770" checksum="826F672A58867364" modified="2006-03-21" version="1">MQRSDSQSTACTINSSYTASTVVSGYSSATDFSLECTLPEDETYRETSSYPDPYSFHDTLDANHMLSATGSQYQQSGIQIPQALQLPNTLQLFGTKAGNEEAAWQATQAANSLIVNRQTFSGGGPFLITSEAVEEALWRHQGRGDEEPVRLAVQAVLRQQLDLRFGDTDHFYPEIVRLLQEAAYQLQIRLQGPDVIDICFLAIAAVLASLTGNLEADNNGVSSGQADDACSPDSVPGQASSSSEKEKFKCPYRGCKHMARRQADLDRHYKIMHLADDQKKGYYCDYPKCGRHTTPFYRQDHFRDHLREYHREDLVRRGSKGGEEWWSDRNPDALKNGWWRCTRCLMKVRSKKNGFACPGCKTCCEKERQQYRQMIANAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTN5</accession>
    <name>Q2GTN5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_08669</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226596.1">
        <property type="nucleotide sequence ID" value="XM_001226595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTN5"/>
    <dbReference type="FunCoup" id="Q2GTN5">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GTN5"/>
    <dbReference type="GeneID" id="4395460"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08669"/>
    <dbReference type="eggNOG" id="KOG4580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141247_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GTN5"/>
    <dbReference type="OMA" id="MAIMIYA"/>
    <dbReference type="OrthoDB" id="2243669at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ84655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="129" mass="14446" checksum="8C407D10AF39AFCB" modified="2006-03-21" version="1">MSSQPLLQTAPGKRIALPTRVEPKVFFANERTFLSWLNFTVILGALAIGMLNFGDRPAFISSFLFTGVAMATMIYALITYHWRAKSIRMRGQAGFDDRFGPTFLAIILLLAVVVNFVLRITYSAQDKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTY1</accession>
    <name>Q2GTY1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_08573</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226500.1">
        <property type="nucleotide sequence ID" value="XM_001226499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTY1"/>
    <dbReference type="FunCoup" id="Q2GTY1">
        <property type="interactions" value="638"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GTY1"/>
    <dbReference type="GeneID" id="4395475"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08573"/>
    <dbReference type="eggNOG" id="KOG0462">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009995_3_1_1"/>
    <dbReference type="InParanoid" id="Q2GTY1"/>
    <dbReference type="OMA" id="QVKCDEN"/>
    <dbReference type="OrthoDB" id="1074at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03699">
        <property type="entry name" value="EF4_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000015">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000007">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2570:FF:000001">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000004">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="46"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="105"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="159"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ84559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="631" mass="69886" checksum="A1F2DBB025998829" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU00</accession>
    <name>Q2GU00_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_08554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226481.1">
        <property type="nucleotide sequence ID" value="XM_001226480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GU00"/>
    <dbReference type="GeneID" id="4395271"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08554"/>
    <dbReference type="HOGENOM" id="CLU_1981403_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GU00"/>
    <dbReference type="OrthoDB" id="10387345at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="126" mass="13670" checksum="D23DE4785F67D5E9" modified="2006-03-21" version="1">MAISRPVRINVESREVSVRAAHHDYGRRINRLPGVGVLVSGISVRAHWSNADLRDGMSFVTSSSGLGTLTGNINMHHPTVAIFVEPGLKEGNGRHMANLGAEHVAREESCPCPNLPMDNEVSSSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUL4</accession>
    <name>Q2GUL4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226267.1">
        <property type="nucleotide sequence ID" value="XM_001226266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUL4"/>
    <dbReference type="STRING" id="306901.Q2GUL4"/>
    <dbReference type="GeneID" id="4394779"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08340"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1687933_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUL4"/>
    <dbReference type="OMA" id="PWARIKY"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="1">
        <location>
            <begin position="22"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="156" mass="17925" checksum="E3B4A27CCC8420EB" modified="2006-03-21" version="1">MARDAGIPLKLCMASVTPATRGLAYTYYTESPFPSFHEFYRGPVLPWARIKYFGRLCMPQEALPGLQNMWPNWWFEPLEAPNWSNLSDTFIRTAEVDPLRDEGEAYAMKLVAGGNKATIKRYLGCPHTFMYIDSMKRKHEYDRDAIIALRAAHSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUR8</accession>
    <name>Q2GUR8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Double-strand break repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CHGG_08286</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the MRN complex composed of two heterodimers RAD50 and MRE11 associated with a single NBS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17 19">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ87033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225942.1">
        <property type="nucleotide sequence ID" value="XM_001225941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUR8"/>
    <dbReference type="FunCoup" id="Q2GUR8">
        <property type="interactions" value="904"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GUR8"/>
    <dbReference type="GeneID" id="4394500"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08286"/>
    <dbReference type="eggNOG" id="KOG2310">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009535_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GUR8"/>
    <dbReference type="OMA" id="ESCMFNA"/>
    <dbReference type="OrthoDB" id="30417at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030437">
        <property type="term" value="P:ascospore formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010791">
        <property type="term" value="P:DNA double-strand break processing involved in repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035753">
        <property type="term" value="P:maintenance of DNA trinucleotide repeats"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010780">
        <property type="term" value="P:meiotic DNA double-strand break formation involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062176">
        <property type="term" value="P:R-loop processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000011">
        <property type="entry name" value="Double-strand break repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
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        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00583">
        <property type="entry name" value="mre11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000882">
        <property type="entry name" value="DSB_repair_MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 17 19" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 17 19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 17 19" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 17 19" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 17 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 17 19" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 17 19" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17 19" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14 17 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="21">
        <location>
            <begin position="290"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="524"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="581"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="598"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="616"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="644"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="670"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="687"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="708"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="18">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00064981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000882-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EAQ87033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="730" mass="82557" checksum="7E63B4E32DD3618E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUX6</accession>
    <name>Q2GUX6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_08228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001225883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUX6"/>
    <dbReference type="GeneID" id="4393816"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08228"/>
    <dbReference type="eggNOG" id="ENOG502QS1J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2359515_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUX6"/>
    <dbReference type="OrthoDB" id="1696280at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ86975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="96" mass="10352" checksum="CF69AC5CB099F98C" modified="2006-03-21" version="1">MEARRYGGPAAMAAGLVDGVGGLEAALGLVRERGLAKKAATGIYGLMKAEMYRESVALLGREGHEEGEVRDRVLVEGEERRRGEGERRVAELKAKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-03-18" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV19</accession>
    <name>POA1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>ADP-ribose 1''-phosphate phosphatase</fullName>
            <ecNumber>3.1.3.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">POA1</name>
        <name type="ORF">CHGG_08185</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ADP-alpha-D-ribose 1''-phosphate + H2O = ADP-D-ribose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:25029"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:58753"/>
            <dbReference type="EC" id="3.1.3.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the POA1 family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="EAQ86932" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="3.1.3.84"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86932.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225841.1">
        <property type="nucleotide sequence ID" value="XM_001225840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV19"/>
    <dbReference type="SMR" id="Q2GV19"/>
    <dbReference type="FunCoup" id="Q2GV19">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="GeneID" id="4393346"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08185"/>
    <dbReference type="eggNOG" id="ENOG502S60W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054419_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GV19"/>
    <dbReference type="OrthoDB" id="2155246at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140291">
        <property type="term" value="P:peptidyl-glutamate ADP-deribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02901">
        <property type="entry name" value="Macro_Poa1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050892">
        <property type="entry name" value="ADP-ribose_metab_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12521:SF0">
        <property type="entry name" value="ADP-RIBOSE GLYCOHYDROLASE OARD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12521">
        <property type="entry name" value="PROTEIN C6ORF130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0904">Protein phosphatase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000324906" description="ADP-ribose 1''-phosphate phosphatase">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Macro">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="27"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="34"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="142"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="185" mass="19900" checksum="FB7C6A7A6E47F114" modified="2008-03-18" version="2">MSPARLRITDRTGDLFAAPANTLLIHACNTVGSWGGGIALAFRNLYPAEFRVYRAHCARSTPNQLVGTALLIAPQRASLNGSGGGGHYIGCLFTSRRFGAARDPPDRILRATGPAMRHLMRLVAEEEERTGVRIGEVRMCRINAGLFAVPWESSKRALEAMELGDGEVPGCAQGGVVEVVAWERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV29</accession>
    <name>Q2GV29_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225831.1">
        <property type="nucleotide sequence ID" value="XM_001225830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV29"/>
    <dbReference type="GeneID" id="4393178"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08175"/>
    <dbReference type="HOGENOM" id="CLU_973188_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GV29"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="286" mass="31037" checksum="6BECD6CDCF543372" modified="2006-03-21" version="1">MCTSIPQVRCEATQKRHVVRVYKKKPPGQLRCGPHISRPGLNPMMPWGSEGVGGGSSERTAHLVEKLLPHGPPPVPITPSLPGTRQPVKAPGSSSLRQAWPTSHPTPAPRSEPGHWNNANWNAMKYLIDLSENVIPGASSLLVGAPVESAILYCPTLTAQPDCVTYSVFPGTPLHLNDAEVVQRHGSKEHFGRVGIAQLPYQRPPCLAVLQDVRPDRDIEVVLDIEEGGPDRSPNQPHHQDASHGRTRKRHGYRFLLNSSLTGRNLGSCYLDMIYVESNGSAPGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV47</accession>
    <name>Q2GV47_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225813.1">
        <property type="nucleotide sequence ID" value="XM_001225812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV47"/>
    <dbReference type="STRING" id="306901.Q2GV47"/>
    <dbReference type="GeneID" id="4393904"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08157"/>
    <dbReference type="HOGENOM" id="CLU_456335_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GV47"/>
    <dbReference type="OrthoDB" id="5086192at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749:SF1">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="598" mass="65945" checksum="25097D803FE6E957" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWE2</accession>
    <name>Q2GWE2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_07712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225368.1">
        <property type="nucleotide sequence ID" value="XM_001225367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWE2"/>
    <dbReference type="GeneID" id="4393140"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07712"/>
    <dbReference type="eggNOG" id="ENOG502QVCK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029630_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GWE2"/>
    <dbReference type="OMA" id="PRQMQYH"/>
    <dbReference type="OrthoDB" id="1001765at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00657">
        <property type="entry name" value="Ferritin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052965">
        <property type="entry name" value="Pigment-catalase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694">
        <property type="entry name" value="DESICCATION-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694:SF8">
        <property type="entry name" value="STRESS RESPONSE PROTEIN RDS1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208242" evidence="2">
        <location>
            <begin position="22"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ86459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="419" mass="44190" checksum="C962940A9C940C05" modified="2006-03-21" version="1">MPSFKKTFGVVVAGLAALSSALPSVPKLSKSQMKMYQHAKRQNAAAAALGLNDVDILQFALTLEWLEATFYQQGFAQFPATDFQALGLEQREIDALIKIGKTEEEHVILLQSAIAQAGVQPVQPCTYNFGFTDAAGMVATAAVLENVGVSAYLGAASLISDTSILTTAGSILTIEARHQTFVRAASRGIPVPQAFDTPLSPKQVFSLAAPFIQSCPDGSNLILTAFPTLSMPAGASATAVAAGAAVQLQSDAASTATHCAFTTGGIPGGTVFVPFDQAAGCVVPQGLAGVTYVNLASAGPLNGVLTDDIIVAGPMVMQVSSIGEDQHIEKRQNTRWHKAGYIRMALHKVEIQHITTMTPPWLCNHVASSSRTDILFSAKRRVSPPDSAWVRAEPVRPGQQRAGQERSTSDEPTKMSCPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWF5</accession>
    <name>Q2GWF5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4048 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_07699</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225355.1">
        <property type="nucleotide sequence ID" value="XM_001225354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWF5"/>
    <dbReference type="GeneID" id="4393300"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07699"/>
    <dbReference type="eggNOG" id="ENOG502S19N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016967_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GWF5"/>
    <dbReference type="OMA" id="PWPAITK"/>
    <dbReference type="OrthoDB" id="4097086at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025122">
        <property type="entry name" value="DUF4048"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13257">
        <property type="entry name" value="DUF4048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4048" evidence="3">
        <location>
            <begin position="399"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="423"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ86446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="659" mass="73059" checksum="4B286DDB3F371892" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWF6</accession>
    <name>Q2GWF6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_07698</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225354.1">
        <property type="nucleotide sequence ID" value="XM_001225353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWF6"/>
    <dbReference type="STRING" id="306901.Q2GWF6"/>
    <dbReference type="GeneID" id="4393595"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07698"/>
    <dbReference type="eggNOG" id="KOG3548">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008949_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWF6"/>
    <dbReference type="OMA" id="PCLAPQW"/>
    <dbReference type="OrthoDB" id="129353at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
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        </location>
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        </location>
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        <location>
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        <location>
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        </location>
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        <location>
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        </location>
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        <source>
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        </source>
    </evidence>
    <sequence length="978" mass="106172" checksum="33AB71DA18834801" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWG3</accession>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWN0</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="7 8">
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        <name type="common">Soil fungus</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        </subcellularLocation>
        <subcellularLocation>
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        </subcellularLocation>
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="SERAC1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ86371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="232" mass="26336" checksum="4A68CF0C0DF1B82D" modified="2006-03-21" version="1">MTAAGVRQEGFTALTKGGSAPIAGLIFVYSFQGHPEKTWTYGKREKEARPMKPMSRVFEVFASRRHAEDSFDQPTYSPPVFWPLDLLAEDFSHVRYDLRDIYESTHAIIFFGTPHRGSSYTKLGILARDIAVLVGLDASGSILRSLEPDAEILRILSDQFAHMLLERSFKIHSFQEAWGSRVLISCRERFSGLDDPGYRKVKGVVSQYLDEIQTVQARDGRQFREAYNVSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX91</accession>
    <name>Q2GX91_CHAGB</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_07413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225069.1">
        <property type="nucleotide sequence ID" value="XM_001225068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX91"/>
    <dbReference type="GeneID" id="4393998"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07413"/>
    <dbReference type="eggNOG" id="ENOG502SKP4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_264089_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GX91"/>
    <dbReference type="OrthoDB" id="5383572at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1031"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1063"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1091"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ86160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1269" mass="141255" checksum="611F6350D2782C47" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX94</accession>
    <name>Q2GX94_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Manganese lipoxygenase</fullName>
            <ecNumber evidence="3">1.13.11.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_07410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(9Z,12Z)-octadecadienoate + O2 = (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate</text>
            <dbReference type="Rhea" id="RHEA:18993"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:57467"/>
            <dbReference type="EC" id="1.13.11.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.13.11.45" evidence="3"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225066.1">
        <property type="nucleotide sequence ID" value="XM_001225065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX94"/>
    <dbReference type="STRING" id="306901.Q2GX94"/>
    <dbReference type="GeneID" id="4394120"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07410"/>
    <dbReference type="eggNOG" id="ENOG502QVKD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009802_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GX94"/>
    <dbReference type="OMA" id="EVWDKGV"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050584">
        <property type="term" value="F:linoleate 11-lipoxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043651">
        <property type="term" value="P:linoleic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034440">
        <property type="term" value="P:lipid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.245.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000907">
        <property type="entry name" value="LipOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013819">
        <property type="entry name" value="LipOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036226">
        <property type="entry name" value="LipOase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11771">
        <property type="entry name" value="LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00305">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00087">
        <property type="entry name" value="LIPOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48484">
        <property type="entry name" value="Lipoxigenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51393">
        <property type="entry name" value="LIPOXYGENASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoxygenase" evidence="9">
        <location>
            <begin position="268"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ86157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="751" mass="84393" checksum="567967BC2694B628" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXP0</accession>
    <name>Q2GXP0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_07264</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224920.1">
        <property type="nucleotide sequence ID" value="XM_001224919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXP0"/>
    <dbReference type="FunCoup" id="Q2GXP0">
        <property type="interactions" value="450"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GXP0"/>
    <dbReference type="GeneID" id="4394630"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07264"/>
    <dbReference type="eggNOG" id="KOG0435">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004427_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GXP0"/>
    <dbReference type="OMA" id="GIEHACM"/>
    <dbReference type="OrthoDB" id="15954at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00812">
        <property type="entry name" value="LeuRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000003">
        <property type="entry name" value="Leucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000338">
        <property type="entry name" value="Leucine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000034">
        <property type="entry name" value="Leucine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740:SF2">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
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    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="13">
        <location>
            <begin position="98"/>
            <end position="231"/>
        </location>
    </feature>
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        <location>
            <begin position="283"/>
            <end position="475"/>
        </location>
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        <location>
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            <end position="657"/>
        </location>
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        <location>
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            <end position="733"/>
        </location>
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        <location>
            <begin position="805"/>
            <end position="931"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="987" mass="109011" checksum="CDFC7AA3D30023E4" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GY02</accession>
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            <fullName evidence="10">FAD/NAD(P)-binding domain-containing protein</fullName>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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            <name>FAD</name>
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        </cofactor>
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        <text evidence="2">Belongs to the FMO family.</text>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="52306" checksum="92B55C0C30824FF8" modified="2006-03-21" version="1">MGSQQPERFDVKKVAIIGAGPCGLAAAKYLLAQKTFHKIDIFEQQAEVGGVWNYSPKPSGTVHVPQTSPYCPPDPPLPREGEEAPVFPSPMYEVLHTNIPRDLMKYSDLPMKEDTLIFPSRQDIQEYVVEYAKEIRHLIQFSTQVKDVHLRVVDGKDQWDVDTACLLTGKTTSATYDAVVVVSGHYTAVYIPDTKGAGKFHKAHPGVISHSKHYRTAEQFTGKKVVVVGNAASGLDIAAQINRVCKKPLLLSVRSPTSQANLDYCGAEEVPVIEEFLPEGRGVRFQDGRIEKDIDAIIYATGYLFAFPFLRSLEPPVVTQGTRVHNTYQHLFHIDHPTLVFTRLPVKVIPFALSESQAAVFSRTWANLLPLPSVKEMRQWEAEEAERQGPKFHVWPEGADGEYINQTYDWIKRSGTPGKEPPHWSPELLWQRQIYAKAKLQFEVQGRKARSLEELGFGYSPDQDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H018</accession>
    <name>Q2H018_CHAGB</name>
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        <recommendedName>
            <fullName evidence="6">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">CHGG_04878</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224092.1">
        <property type="nucleotide sequence ID" value="XM_001224091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H018"/>
    <dbReference type="STRING" id="306901.Q2H018"/>
    <dbReference type="GeneID" id="4392944"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04878"/>
    <dbReference type="eggNOG" id="KOG1844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009510_1_0_1"/>
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    <dbReference type="OMA" id="IKCICSF"/>
    <dbReference type="OrthoDB" id="1928087at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="285"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
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        <location>
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            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="723"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="504"/>
            <end position="517"/>
        </location>
    </feature>
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        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
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            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
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        <location>
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            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
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            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="723"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="797"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="819"/>
            <end position="838"/>
        </location>
    </feature>
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        <location>
            <begin position="918"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ88259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="942" mass="102540" checksum="DC7B5396F314A2B2" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0C3</accession>
    <name>Q2H0C3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_04773</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223987.1">
        <property type="nucleotide sequence ID" value="XM_001223986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0C3"/>
    <dbReference type="STRING" id="306901.Q2H0C3"/>
    <dbReference type="GeneID" id="4391905"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04773"/>
    <dbReference type="eggNOG" id="KOG0773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008497_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H0C3"/>
    <dbReference type="OMA" id="TIHNYSR"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="85"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="HTH CENPB-type" evidence="9">
        <location>
            <begin position="640"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="87"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="209"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="625"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="740"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1025"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="209"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="625"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1026"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1041"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ88154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1089" mass="119805" checksum="0D32C69B6181C3F4" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0F5</accession>
    <name>Q2H0F5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Activating signal cointegrator 1 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_04741</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223955.1">
        <property type="nucleotide sequence ID" value="XM_001223954.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2H0F5">
        <property type="interactions" value="574"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H0F5"/>
    <dbReference type="GeneID" id="4392222"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04741"/>
    <dbReference type="eggNOG" id="KOG0952">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000335_2_1_1"/>
    <dbReference type="InParanoid" id="Q2H0F5"/>
    <dbReference type="OMA" id="MCSATEF"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DEXHc_ASCC3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18022">
        <property type="entry name" value="DEXHc_ASCC3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000198">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000002">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000231">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF13">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
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    </dbReference>
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    </dbReference>
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        </source>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2013" mass="225680" checksum="82D78991DB80D61C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0Z1</accession>
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        <submittedName>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="134"/>
        </location>
    </feature>
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            <begin position="25"/>
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        </location>
    </feature>
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            <end position="73"/>
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    </feature>
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        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="134" mass="12924" checksum="486DE68E391A918C" modified="2006-03-21" version="1">MRFAVAASWFLATLAVASPVPVDTIKPATDALGAPGAPDTGSADVLRTPGTPGTDSVNTLKTPGVPDTNSANALGTPGVPGTGSADALKTPGVPDTDSASALGKPELPDTESATSAADSAAALVDRASGDVPCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H111</accession>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
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            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04535"/>
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    <dbReference type="OrthoDB" id="427518at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ87916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11160" checksum="E5A0AE6CED8C30C1" modified="2006-03-21" version="1">MGNLASTYRNQGRWKEAEALEVQVMETRKRMLGEEHPDTLASMNNLAFTWKGIGRDGDALGLLQTCFDLQQQVLGEAHPSTVSTLSALEAWLEENEQPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H133</accession>
    <name>Q2H133_CHAGB</name>
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        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001223726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H133"/>
    <dbReference type="STRING" id="306901.Q2H133"/>
    <dbReference type="GeneID" id="4392717"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04513"/>
    <dbReference type="eggNOG" id="ENOG502S670">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016396_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H133"/>
    <dbReference type="OMA" id="SKCFVAY"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12432">
        <property type="entry name" value="RRM_ACINU"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034257">
        <property type="entry name" value="Acinus_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47031">
        <property type="entry name" value="SAP DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47031:SF3">
        <property type="entry name" value="SAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="661"/>
        </location>
    </feature>
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        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="661" mass="74633" checksum="BA165B45BFB42216" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H155</accession>
    <name>Q2H155_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_04491</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223705.1">
        <property type="nucleotide sequence ID" value="XM_001223704.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2H155">
        <property type="interactions" value="719"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H155"/>
    <dbReference type="GeneID" id="4392700"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04491"/>
    <dbReference type="eggNOG" id="KOG1240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001696_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H155"/>
    <dbReference type="OMA" id="ATNTCRI"/>
    <dbReference type="OrthoDB" id="242910at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13980">
        <property type="entry name" value="STKc_Vps15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000497">
        <property type="entry name" value="Phosphoinositide 3-kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001688">
        <property type="entry name" value="Phosphoinositide 3-kinase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="25"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1050"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="846"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="931"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1410"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="874"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1410"/>
            <end position="1424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ87872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1483" mass="165664" checksum="35B9BE7BF44A156F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H166</accession>
    <name>Q2H166_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223694.1">
        <property type="nucleotide sequence ID" value="XM_001223693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H166"/>
    <dbReference type="STRING" id="306901.Q2H166"/>
    <dbReference type="GeneID" id="4391795"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04480"/>
    <dbReference type="HOGENOM" id="CLU_711723_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H166"/>
    <dbReference type="OMA" id="TPDPHRN"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="388" mass="41495" checksum="259B4BDF689FB4B6" modified="2006-03-21" version="1">MDGTAQTGPKEQAAPTATSPASIPQQQASDAPAVAVAVAVLEMAQAAASPITTENQDTAINTNVNGVVGTDIQSTNPGTARATSPPLHHQTTADAASNRQPPTPAMSGPDSSTTRQDQPGNEKPLRWKDPMTVQANGPTQSANLESPGNGAAESPQQQGQQQHPGPSQQPQYHQHPHPHPYAQPQHHLQPQPAPALTPISPSTPATLPPPPPAAHAHHGPLQPPSQPQPQQSQPQPHHQQLRPRAPPPQYSSPTSHARPHPLPPPPHLQHPAPQTPHAQIPQQYPHQHHQHQHHQHHHPHPPSSSAPATPLTSLPPLQHPHATQFHSYRQPQPQPQPQSQPVLKSQAAHHSAFVSRPIIMDPPGTRKQDQQRVGAMGFPSPTQDLCPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1F4</accession>
    <name>Q2H1F4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPI-anchor transamidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_04392</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223606.1">
        <property type="nucleotide sequence ID" value="XM_001223605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1F4"/>
    <dbReference type="FunCoup" id="Q2H1F4">
        <property type="interactions" value="585"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H1F4"/>
    <dbReference type="MEROPS" id="C13.005"/>
    <dbReference type="GeneID" id="4392162"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04392"/>
    <dbReference type="eggNOG" id="KOG1349">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044656_2_2_1"/>
    <dbReference type="InParanoid" id="Q2H1F4"/>
    <dbReference type="OMA" id="VMESQFP"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000003">
        <property type="entry name" value="GPI-anchor transamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500138">
        <property type="entry name" value="GPI8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027847648" description="GPI-anchor transamidase" evidence="6">
        <location>
            <begin position="27"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ87773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="44172" checksum="A4D7D52334E266E2" modified="2006-03-21" version="1">MKLSGLFGLPALLAATVLAPAALVGAEHTSNWAVLVCTSRFWFNYRHLANVLSMYRTVKRLGIPDSQIILMLPDDMACNPRNAFPGTVYSNADRAVDLYGDNIEVDYRGYEVTVENFIRLLTDRVGEEMPRSKRLLTDDRSNILVYMTGHGGNEFLKFQDAEEIGAFDLADAFEQMWEKKRYNEILFMIDTCQANTMYSKLYSPNIIATGSSELDQSSYSHHADNDIGVAVIDRYTYYNLEFLETEVRDTSSKKTVGDLFDSYTFEKIHSHAGVRYDLFRGGAEAARKRLVTDFFGNVQNVEVDAAKNTTALDEDILALSRTIAALHRKAEEEETALKKNVSGEAETTSPKQKKVQFAKPLTDENWWTKKILGAAAVAGCTALWGLSSLLEGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H259</accession>
    <name>Q2H259_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_04137</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223351.1">
        <property type="nucleotide sequence ID" value="XM_001223350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H259"/>
    <dbReference type="STRING" id="306901.Q2H259"/>
    <dbReference type="GeneID" id="4391710"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04137"/>
    <dbReference type="eggNOG" id="KOG3923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034311_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H259"/>
    <dbReference type="OMA" id="GANWSPM"/>
    <dbReference type="OrthoDB" id="409956at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF16">
        <property type="entry name" value="D-AMINO ACID OXIDASE (AFU_ORTHOLOGUE AFUA_5G11290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="9"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="30"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ87518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="349" mass="38181" checksum="ED73A7B5426866EA" modified="2006-03-21" version="1">MPNIVVLGQKGNVVTVVAKHMPGDYDIEYTSPWAGANVLPMSLDKDSRWERRTWPELRRLAAEVPEAGLHVQTARVLRRQADVTPEGLKSAMVDGLYQFSPWYQELMDDFRELPAAELPEGMHSGCEFTSVCINTAIYLPWLVGQCARLGVRFRRAVLKHISEAAALSHTGERADLVVNASGLLACRLGGVMDATVIPARGQIVLVRNEAAGIMPTTSGCADGDDEVVYVMQRALGGGTVLGGTYMRGNWEANPDPNMAMRIMRRAVEMHPELTGGKGVEGLDIIRHGVGLRPLRKGGVRIEKELIDGTWVVHNYGHAGWGYQGSFGCAERVVELVDEVLGKAKRESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2C3</accession>
    <name>Q2H2C3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_04073</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223287.1">
        <property type="nucleotide sequence ID" value="XM_001223286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2C3"/>
    <dbReference type="GeneID" id="4392615"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04073"/>
    <dbReference type="eggNOG" id="ENOG502RKIT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_453399_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2C3"/>
    <dbReference type="OMA" id="HAYSEAY"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="3">
        <location>
            <begin position="130"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="344"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ87454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="602" mass="69842" checksum="8A8709563E623331" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H381</accession>
    <name>Q2H381_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chitin synthase</fullName>
            <ecNumber evidence="5">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_03765</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the chitin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="5"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222979.1">
        <property type="nucleotide sequence ID" value="XM_001222978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H381"/>
    <dbReference type="STRING" id="306901.Q2H381"/>
    <dbReference type="GeneID" id="4392536"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03765"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_897144_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H381"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF38">
        <property type="entry name" value="CHITIN SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ87146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="310" mass="34901" checksum="678BE6C2E7F7C62F" modified="2006-03-21" version="1">MYNEDEYGFTRTMHAVMKNISHFCSRNRSRTWGEFGWQKIVVCIVSDGREKIHPRTLDALAAMGVYQHGIAKNYVNQKAVQAHVYEYTTQVSLDSDLKFKGAEKGIVPCQMIFCLKEKNQKKLNSHRWFFNAFGKALNPNVVFGYITVLPGALSAYRYHALQNDETGHGPLSQYFKGETLHGQHADVFTANMYLAEDRILCWELVAKRGERWVLKYVKGCTGETDVPGMFTKPLFRPPTSNHLQIPSPSLSRSDVVGSTVPSSRLSTRWFTSGKSGRRTTPSLGRSCYTSSLCTSSSSSSLRICRLPTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3I4</accession>
    <name>Q2H3I4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_06781</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222876.1">
        <property type="nucleotide sequence ID" value="XM_001222875.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4390629"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06781"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="InParanoid" id="Q2H3I4"/>
    <dbReference type="OMA" id="FCISNWA"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="572"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="713"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1136"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1169"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1208"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1248"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1279"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="73"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="796"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="755"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1075"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="766"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ90162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1416" mass="156207" checksum="B92B65F10204DF37" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3L1</accession>
    <name>Q2H3L1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_06754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222849.1">
        <property type="nucleotide sequence ID" value="XM_001222848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3L1"/>
    <dbReference type="STRING" id="306901.Q2H3L1"/>
    <dbReference type="GeneID" id="4390802"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06754"/>
    <dbReference type="eggNOG" id="ENOG502SC94">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3124905_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3L1"/>
    <dbReference type="OrthoDB" id="5520611at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ90135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="50" mass="5552" checksum="743079177B03D031" modified="2006-03-21" version="1">MSWFGVTPLKKFPAPVLRPMAPFLAAADEFKNDPQEPQREGCALGGGYEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3M6</accession>
    <name>Q2H3M6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222834.1">
        <property type="nucleotide sequence ID" value="XM_001222833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3M6"/>
    <dbReference type="GeneID" id="4390992"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06739"/>
    <dbReference type="eggNOG" id="ENOG502S808">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_317344_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3M6"/>
    <dbReference type="OrthoDB" id="4144003at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="17"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="883"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="918" mass="102745" checksum="7F3306CA73077A48" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3P4</accession>
    <name>Q2H3P4_CHAGB</name>
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        <recommendedName>
            <fullName evidence="2">Spermatogenesis-associated protein 20-like TRX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_06721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222816.1">
        <property type="nucleotide sequence ID" value="XM_001222815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3P4"/>
    <dbReference type="STRING" id="306901.Q2H3P4"/>
    <dbReference type="GeneID" id="4391356"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06721"/>
    <dbReference type="eggNOG" id="KOG2244">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014051_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H3P4"/>
    <dbReference type="OMA" id="PFYFGTY"/>
    <dbReference type="OrthoDB" id="1923667at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="Ssp411-like_TRX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="32"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ90102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="811" mass="89170" checksum="B3166EA25F27E89B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H408</accession>
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        <recommendedName>
            <fullName evidence="4">Transcription factor RfeG</fullName>
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    </protein>
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        <name evidence="2" type="ORF">CHGG_06607</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222702.1">
        <property type="nucleotide sequence ID" value="XM_001222701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H408"/>
    <dbReference type="STRING" id="306901.Q2H408"/>
    <dbReference type="GeneID" id="4390820"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06607"/>
    <dbReference type="eggNOG" id="ENOG502SQKQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037532_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H408"/>
    <dbReference type="OMA" id="TEPPFRD"/>
    <dbReference type="OrthoDB" id="4146887at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609:SF1">
        <property type="entry name" value="RFEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609">
        <property type="entry name" value="RFEG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="44148" checksum="F78E06D7F3736D11" modified="2006-03-21" version="1">MAGRPNNRSSQQAPAVPPASARQNEYFVPRDGIDREVITSDICRYLGNDALVRPGTYESADGRVTQGYYITAYRNLTSPMIQDLKADSARWEQERRAASRSSGGGAGGSREQPRGQDYNAWKNLQREREFAEAQYPSAMDVDFAPPPGPSATPVYSGQQYAGAPPANYPPATYPPQGHAAAAQYQAQPGYGYPPNPPPTQYSPQPQTSGDRYPGIPPPPIAGSYAQDAGAFVHGSNYQTAGGYAAPGPNRMPPAMINASAAPSRTYSAPTAGTPVYGGETDPYAYPPPAANSVPQGYPTDALYGRGAYATATTNPPEAASSDVLGSPAGTTQRPGYPAPTDPQYDAHQNPALQSATTPTTAAPAQMATGSVPPPARRDRDSEPREREREHRDHRPRRSEQEREDRNRHRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4E2</accession>
    <name>Q2H4E2_CHAGB</name>
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        <recommendedName>
            <fullName evidence="9">DUF803 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_06473</name>
    </gene>
    <organism evidence="7 8">
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001222567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4E2"/>
    <dbReference type="GeneID" id="4391421"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06473"/>
    <dbReference type="eggNOG" id="KOG2922">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011406_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H4E2"/>
    <dbReference type="OMA" id="KPFIVWM"/>
    <dbReference type="OrthoDB" id="2504919at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.20:FF:000012">
        <property type="entry name" value="DUF803 domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF86">
        <property type="entry name" value="ADR321CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
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        <source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="62490" checksum="B11CABE237C99F61" modified="2006-03-21" version="1"> </sequence>
</entry>
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    <accession>Q2H4M8</accession>
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        </submittedName>
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            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
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        <property type="entry name" value="BCDNA.GH02901"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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            <dbReference type="Pfam" id="PF13193"/>
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    </evidence>
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            <dbReference type="EMBL" id="EAQ89768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="438" mass="48287" checksum="C402A8998850859B" modified="2006-03-21" version="1">MGSVYTNLGQTRPTRSSIGEFMRNEIYGRCPISKSRNPFTCGLTGKTYTVTESHKRSDLIAKSLAKVMGWEPNADSPWDKVVAVFSFNTIDYLSVLNAVHRLSGVATPANVAYSAEELEHHLRSSGAKALFTCVPVLETALMAAKALGIPKDKIFFIKAVMISHQNVIANTMQYCIFENVSRKSEGIETQLTVQVPPIVVRMLSSKDMLKKYDLSSVRLVFTGAAPLGKETSDELIRLYPKWRVGQGYVVDRGVLDERARYLPWEPSGSLMPGARAKVVDPDGKEIHEYGKPGELLVQSPSVTLGYLNNEKATAEAFIWDEEGSVAEDGRRVAPAELEAHLLAHPAVDDCAVISVPDARDGEAPKAFVVTPASMASRSDEEMAAEIIKHVQDYKAHYKWLKGGIEFIDAIPKSPSGKILRRLLRDREKEARRANGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
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                <person name="Untereiner W.A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="FI21118P1"/>
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    </dbReference>
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        <property type="entry name" value="G-patch"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="99"/>
        </location>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="803" mass="88239" checksum="9A5A89FB364367BF" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5A9</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CHGG_06156</name>
    </gene>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89537.1"/>
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    <dbReference type="GeneID" id="4390581"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06156"/>
    <dbReference type="eggNOG" id="KOG3041">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062658_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H5A9"/>
    <dbReference type="OMA" id="NDPGLCN"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF1">
        <property type="entry name" value="ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="148" mass="16170" checksum="3C04FDC587DAD49B" modified="2006-03-21" version="1">MSGEAKVISTGPLPASEAVWTKLVKKTYKDPNGVTRTWESAERTTRPKGSDIDGVGIVAILEKETDPGFCNTNLRMVHVTVDMSLPANQDLKPELEENEFIEVFLVKLVDLWEECIKLEAQGYAIDARIANLAEGIEIGQEVQALGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5I5</accession>
    <name>Q2H5I5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_06080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222175.1">
        <property type="nucleotide sequence ID" value="XM_001222174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5I5"/>
    <dbReference type="GeneID" id="4391283"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06080"/>
    <dbReference type="eggNOG" id="ENOG502QQIE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012066_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H5I5"/>
    <dbReference type="OMA" id="VEYCIPE"/>
    <dbReference type="OrthoDB" id="415532at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049207">
        <property type="entry name" value="DUF4246_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119">
        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21666">
        <property type="entry name" value="DUF4246_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="3">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="2">
        <location>
            <begin position="113"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ89461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="716" mass="81510" checksum="5CCA967BD7E25A60" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5U6</accession>
    <name>Q2H5U6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_05969</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222064.1">
        <property type="nucleotide sequence ID" value="XM_001222063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5U6"/>
    <dbReference type="FunCoup" id="Q2H5U6">
        <property type="interactions" value="826"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H5U6"/>
    <dbReference type="GeneID" id="4390274"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05969"/>
    <dbReference type="eggNOG" id="KOG0400">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090139_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H5U6"/>
    <dbReference type="OMA" id="MHTRRKG"/>
    <dbReference type="OrthoDB" id="623277at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.130:FF:000001">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ89350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="151" mass="16809" checksum="D4933A08B80854CC" modified="2006-03-21" version="1">MGRLHSNGKGISSSAIPYSRTAPAWLKTTPEQVVDHICKLAKKGATPSQIGVVLRDSHGIAQVKVVTGNKILRILKSNGLAPDIPEDLYMLIKKAVAVRKHLERNRKDRDSKFRLILIESRIHRLARYYKTVGVLPPTWKYESSTASTLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H603</accession>
    <name>Q2H603_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin cytoskeleton-regulatory complex protein SLA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_05912</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222007.1">
        <property type="nucleotide sequence ID" value="XM_001222006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H603"/>
    <dbReference type="FunCoup" id="Q2H603">
        <property type="interactions" value="118"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H603"/>
    <dbReference type="GeneID" id="4391055"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05912"/>
    <dbReference type="eggNOG" id="ENOG502QQC3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003674_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H603"/>
    <dbReference type="OMA" id="FMAQGED"/>
    <dbReference type="OrthoDB" id="26539at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11774">
        <property type="entry name" value="SH3_Sla1p_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11775">
        <property type="entry name" value="SH3_Sla1p_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000256">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.700">
        <property type="entry name" value="SLA1 homology domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
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        <property type="entry name" value="PH_SLA1"/>
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        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
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        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SH3_domain"/>
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        <property type="entry name" value="SHD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035821">
        <property type="entry name" value="Sla1_SH3_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF19">
        <property type="entry name" value="ACTIN CYTOSKELETON-REGULATORY COMPLEX PROTEIN SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24081">
        <property type="entry name" value="PH_SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03983">
        <property type="entry name" value="SHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="98"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="439"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="159"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="507"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="671"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="769"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1134"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="279"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="523"/>
            <end position="551"/>
        </location>
    </feature>
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        <location>
            <begin position="562"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="598"/>
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        </location>
    </feature>
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        <location>
            <begin position="797"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="813"/>
            <end position="836"/>
        </location>
    </feature>
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        <location>
            <begin position="851"/>
            <end position="876"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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        </location>
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        <location>
            <begin position="987"/>
            <end position="998"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007948"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00020357"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ89293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1192" mass="128266" checksum="255B85F4F93CFD70" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7J6</accession>
    <name>Q2H7J6_CHAGB</name>
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        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">CHGG_05369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ88750.1"/>
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    </dbReference>
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    <dbReference type="STRING" id="306901.Q2H7J6"/>
    <dbReference type="GeneID" id="4390422"/>
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    <dbReference type="eggNOG" id="ENOG502S3M7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
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        <location>
            <begin position="82"/>
            <end position="139"/>
        </location>
    </feature>
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        <location>
            <begin position="170"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
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        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
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        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="42700" checksum="2FDF6B2F6239283A" modified="2006-03-21" version="1">MSPAMQMTGQHAPYTPRSDAMDRHDYGITKNRKTASTGGGRAWSEDEEAYLLQTRMQKMPYKHIAAYLKKTELACRLHYHQLSHGSNRRKRTTSMSSGSSNSHSPILHASIPSPIHEHGGAPSRSVSPPDSAYSAISPGGIQLPSIMSATASTSTSPRLPTILPKPASMNLAMSSMNGSNSTGTSPTASRGYPTPLHDTHPPNMAPMNSTGYRGGAPNPPARGTTAGPLRLDCSALPPPPSTNGLPAPPGFAASHPVDMARLTAVYNAHRASFWAAVAADYGPGANPLVLEQAWRGTSSATAPGCPPSGSASAAASMGIAAQTPITPVGSPDDQIYSAGVVHHHHAAAHGHGQQQQQHMHHGHGGMGKPDKTRISAILGIDANPRSPSEREMVRRIEEERGAVGVGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7M1</accession>
    <name>Q2H7M1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001221438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7M1"/>
    <dbReference type="GeneID" id="4390562"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05344"/>
    <dbReference type="HOGENOM" id="CLU_2037791_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7M1"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="121" mass="13581" checksum="52E395F060CB85AE" modified="2006-03-21" version="1">MKQEATAGAEGVKRNRTEDDEFLPGTLNLSQLRWNPNRNPESARSGERPRLHTTRPGCRPSAQVEMSKLLISPRNSAAIRTTPQQKTATRERAFQPKRSSEKPTDQECRRQPGASAARWTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7U0</accession>
    <name>Q2H7U0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Leptomycin B resistance protein pmd1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_05275</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221370.1">
        <property type="nucleotide sequence ID" value="XM_001221369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7U0"/>
    <dbReference type="FunCoup" id="Q2H7U0">
        <property type="interactions" value="668"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H7U0"/>
    <dbReference type="GeneID" id="4391275"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05275"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_17_8_1"/>
    <dbReference type="InParanoid" id="Q2H7U0"/>
    <dbReference type="OMA" id="NYDNHKQ"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000057">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
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        <property type="entry name" value="ABC multidrug transporter SitT"/>
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        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ABC1_TM_sf"/>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
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        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
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    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="84"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="129"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="180"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="206"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="320"/>
            <end position="340"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="602"/>
            <end position="625"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="645"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="710"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="742"/>
            <end position="760"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="857"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="58"/>
            <end position="348"/>
        </location>
    </feature>
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        <location>
            <begin position="383"/>
            <end position="651"/>
        </location>
    </feature>
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            <begin position="607"/>
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    </feature>
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            <begin position="921"/>
            <end position="1175"/>
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    </feature>
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        <location>
            <begin position="1"/>
            <end position="35"/>
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    </feature>
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        <location>
            <begin position="531"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
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    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ88656.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1179" mass="127975" checksum="EEEEFE534C173AD1" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7Y7</accession>
    <name>Q2H7Y7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CHGG_03667</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
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        <property type="protein sequence ID" value="EAQ91732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001230182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7Y7"/>
    <dbReference type="GeneID" id="4388387"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03667"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_010365_6_0_1"/>
    <dbReference type="InParanoid" id="Q2H7Y7"/>
    <dbReference type="OMA" id="FWTEWVR"/>
    <dbReference type="OrthoDB" id="3944240at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
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    </dbReference>
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        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FAD-bd_8"/>
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        <property type="entry name" value="FAD-bd_FR_type"/>
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        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
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    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
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    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
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        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_binding_8"/>
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    </dbReference>
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        <property type="entry name" value="Ferric_reduct"/>
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    </dbReference>
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        <property type="entry name" value="NAD_binding_6"/>
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    </dbReference>
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        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="317"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="523"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAQ91732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="635" mass="71265" checksum="5963AC58B3ACA56E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8E3</accession>
    <name>Q2H8E3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230027.1">
        <property type="nucleotide sequence ID" value="XM_001230026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8E3"/>
    <dbReference type="STRING" id="306901.Q2H8E3"/>
    <dbReference type="GeneID" id="4388712"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03511"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_495201_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8E3"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="550" mass="60823" checksum="A38E5C602C379BAD" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8P8</accession>
    <name>Q2H8P8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229922.1">
        <property type="nucleotide sequence ID" value="XM_001229921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8P8"/>
    <dbReference type="GeneID" id="4389789"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03406"/>
    <dbReference type="eggNOG" id="ENOG502RIXV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_849921_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8P8"/>
    <dbReference type="OrthoDB" id="4579941at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="327" mass="36767" checksum="AE93F540CA7527FD" modified="2006-03-21" version="1">MSEGRVLGEMLETLQRLETRIDGQKDRLDAIELSIRSGGASSMATSSSIVNSDHDSTAAEHLHECPSPITPPSAEQPTYPASVYRASIAEMRKRFEFVDASCSDVHPMQAASPDNLQWDQTGVASNPNQDEGYEHEVVYTESAYSRPLSRLDLGDMAEAPPLPNNIQFQTDFQGRAVPSYSGEQHHEPVVDTRELQTSHSDPAHTQDEIRAVRYEDVHFHSIQAQKETSQTTGARPDISRRHEHVEVMYLAWDNFKTSLRPSWWLFSSEHRAALNEKRRLGELCGTGATPRQRLGEVLKWYKLAIKVIRRTKTRGLGKGDMVSVVQM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8S0</accession>
    <name>MED10_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">NUT2</name>
        <name type="synonym">MED10</name>
        <name type="ORF">CHGG_03384</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229900.1">
        <property type="nucleotide sequence ID" value="XM_001229899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8S0"/>
    <dbReference type="SMR" id="Q2H8S0"/>
    <dbReference type="FunCoup" id="Q2H8S0">
        <property type="interactions" value="498"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H8S0"/>
    <dbReference type="GeneID" id="4388777"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03384"/>
    <dbReference type="eggNOG" id="KOG3046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096169_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8S0"/>
    <dbReference type="OMA" id="QYQRAKM"/>
    <dbReference type="OrthoDB" id="337270at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345:SF13">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000303168" description="Mediator of RNA polymerase II transcription subunit 10">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="167" mass="18297" checksum="51DD3CCAE59004F7" modified="2006-03-21" version="1">MAPINPDLQNVQDDIKNVIQDLFQVLVQVSNYDAAGRPTRDVLAQDIQTLDKTLHTLHTNAQHLPTPTADKPIPEPLIQYVENGRNPDIYTREFAELVRRMNQLARGKMHAFRDFRDVLAREMESALPELRADVQMVVGATGGRTVGGEGEGAGQGEGGEGRGEGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9I1</accession>
    <name>Q2H9I1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase regulator Ste50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_03123</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229639.1">
        <property type="nucleotide sequence ID" value="XM_001229638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9I1"/>
    <dbReference type="STRING" id="306901.Q2H9I1"/>
    <dbReference type="GeneID" id="4388447"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03123"/>
    <dbReference type="eggNOG" id="ENOG502QQYX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021546_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9I1"/>
    <dbReference type="OMA" id="DWTAEEC"/>
    <dbReference type="OrthoDB" id="445896at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01786">
        <property type="entry name" value="RA_STE50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09533">
        <property type="entry name" value="SAM_Ste50-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051569">
        <property type="entry name" value="SHANK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135:SF28">
        <property type="entry name" value="LD13733P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135">
        <property type="entry name" value="SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="47"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="3">
        <location>
            <begin position="324"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ91188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="47119" checksum="1FC8D64889236F50" modified="2006-03-21" version="1">MHNSSPIATDLETSPIDSDPPSAEHTPTTYGYRASADRLPETIISEWTADECADFIASIGLQQYADIFLENEIVGEALVALQHEDLKAMGLNSVGHRLTILKSVFDVKKAQDVPIESDHYMPLTAETQAQSSRLREDVLPAVRMVKDAQQPLPNLSNGPAYESTLSPPAPTPSTAQSAVGLKRQYSTKEIMLGTTAKATSPTHLQTNHDRSIVEQTLDPSSAAERAVLSSSHLAAMNGSGGSASSPSYPSPNMPSPTSPPTGMLSGTTLGARSYRAGGEPTPSSRSTFAPDDSYNQAKNTAPRRMQTPAPETPGAASNASVEIFKSFRVSMDDPCYKVLPAALKKYQINAPWDQYALYIVYGDQERCLALDEKPLILFKQLDKEGKKPMFMLRKTNNASADGAAAPDGTPGSAGLVGPGSSTAAAAAAAARGVGGAGVGYDPPGGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9S4</accession>
    <name>Q2H9S4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_03030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229546.1">
        <property type="nucleotide sequence ID" value="XM_001229545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9S4"/>
    <dbReference type="GeneID" id="4388498"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03030"/>
    <dbReference type="eggNOG" id="KOG4266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1184896_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9S4"/>
    <dbReference type="OMA" id="ELARCKF"/>
    <dbReference type="OrthoDB" id="4589541at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00306">
        <property type="entry name" value="Peptidases_S8_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="5">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ91095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="234" mass="25597" checksum="7DC1FA70A255E917" modified="2006-03-21" version="1">MCLGFQEEHDPIEEAVDKAIDAGKLIIAAASNNGGLSGRARPARHEGVICIHATDGRGNKGGMNPSPLPNRNNFATLGVAVRCLWKGKVWKSGTSFAVPIAAGFAADIMEFARCRCTNLKSRKLKKLQRKDGMRAIFERMEKLRDGYDFIAPRSCGTGGGVHKRSRILWILLSAQWSPSSRVQSRTLLKDLSTYILNGSRLLLPCSLSHSSVRSLARSDGRLDSKTNSRACPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HB37</accession>
    <name>Q2HB37_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zinc transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_02567</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a zinc transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229083.1">
        <property type="nucleotide sequence ID" value="XM_001229082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HB37"/>
    <dbReference type="FunCoup" id="Q2HB37">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HB37"/>
    <dbReference type="GeneID" id="4389324"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02567"/>
    <dbReference type="eggNOG" id="ENOG502QV77">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024994_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HB37"/>
    <dbReference type="OMA" id="ADYGRSP"/>
    <dbReference type="OrthoDB" id="5382797at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF5">
        <property type="entry name" value="ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="200"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="437"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ90632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="577" mass="62215" checksum="18734AECE8BE3716" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBD2</accession>
    <name>Q2HBD2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent DNA ligase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_02472</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228988.1">
        <property type="nucleotide sequence ID" value="XM_001228987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBD2"/>
    <dbReference type="STRING" id="306901.Q2HBD2"/>
    <dbReference type="GeneID" id="4389388"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02472"/>
    <dbReference type="eggNOG" id="KOG0966">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004299_4_0_1"/>
    <dbReference type="InParanoid" id="Q2HBD2"/>
    <dbReference type="OMA" id="YEHLYIM"/>
    <dbReference type="OrthoDB" id="2160351at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF2">
        <property type="entry name" value="ATP DEPENDENT DNA LIGASE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G02430)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="7">
        <location>
            <begin position="344"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="673"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="759"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="801"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="894"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="818"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="898"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ90537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1002" mass="111219" checksum="FFC8FA471C8FB7BB" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCI7</accession>
    <name>Q2HCI7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11 12">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4 11 12">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_02067</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11 12">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4 11 12"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221288.1">
        <property type="nucleotide sequence ID" value="XM_001221287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCI7"/>
    <dbReference type="GeneID" id="4386669"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02067"/>
    <dbReference type="eggNOG" id="ENOG502RXA7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052631_3_1_1"/>
    <dbReference type="InParanoid" id="Q2HCI7"/>
    <dbReference type="OMA" id="QPRECGI"/>
    <dbReference type="OrthoDB" id="2115822at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018208">
        <property type="entry name" value="GH11_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033119">
        <property type="entry name" value="GH11_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF2">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00776">
        <property type="entry name" value="GH11_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00777">
        <property type="entry name" value="GH11_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11 12" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209202" description="Endo-1,4-beta-xylanase" evidence="13">
        <location>
            <begin position="17"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="14">
        <location>
            <begin position="44"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ93832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="238" mass="25732" checksum="8C2EE475076A25F9" modified="2006-03-21" version="1">MLKSLVLSAVLAAAVPLDEQLFGKSFNLGSRINTAGQGSQGIAAGSPEGNGFHSGYFYSFWSDGRGSVTYNNLANGSYNSQWNNVGNWVGGKGWNPGGPKTVHYNGTWNAANVNSYLALYGWTKDPLIEYYIVESYGSYNPSSGAQRRGTIQSDGGTYDIYQTQRVNQPSIVGRATFMQFWSHFDAWTKSGLKLGSHDYMILATEGYQSSGSSSITVGEVGVEGVPYPDEPDSVRPNN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-20" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDQ7</accession>
    <name>PSF1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PSF1</name>
        <name type="ORF">CHGG_01647</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220868.1">
        <property type="nucleotide sequence ID" value="XM_001220867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDQ7"/>
    <dbReference type="SMR" id="Q2HDQ7"/>
    <dbReference type="FunCoup" id="Q2HDQ7">
        <property type="interactions" value="389"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HDQ7"/>
    <dbReference type="GeneID" id="4388014"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01647"/>
    <dbReference type="eggNOG" id="KOG3303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079191_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HDQ7"/>
    <dbReference type="OMA" id="MFCEKAT"/>
    <dbReference type="OrthoDB" id="10252587at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21696">
        <property type="entry name" value="GINS_B_Psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1030:FF:000003">
        <property type="entry name" value="DNA replication complex GINS protein PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056783">
        <property type="entry name" value="PSF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24997">
        <property type="entry name" value="PSF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000278397" description="DNA replication complex GINS protein PSF1">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="213" mass="23734" checksum="C1D0C49970467BC3" modified="2006-03-21" version="1">MPMYGDLGNKLVQHAKRTQNLTHLPPYQTELVRAVTREVRDLDKDVASLLEPFQGSFDPSTDQATACTLLVNHLSMRRNKRCLLAYHRTRTDKLEELVWNGSDVLDLAGQQAGGVNGAAADSGAGSSLSPQEEDYFRQYGDLLSAYKGQWTDIDLTGSLEPPRDLFIDVRVLKDAGEIQTEYGAINLTKNSQFYVRQGDVERLIAQGYLQKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEG6</accession>
    <name>Q2HEG6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220609.1">
        <property type="nucleotide sequence ID" value="XM_001220608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEG6"/>
    <dbReference type="FunCoup" id="Q2HEG6">
        <property type="interactions" value="362"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HEG6"/>
    <dbReference type="GeneID" id="4387060"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01388"/>
    <dbReference type="eggNOG" id="KOG3381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075876_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HEG6"/>
    <dbReference type="OMA" id="NQCISAR"/>
    <dbReference type="OrthoDB" id="2746at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="196" mass="21613" checksum="A0DD4B5943ADADE3" modified="2006-03-21" version="1">MERDLENANPTILNVSQLPSRQRKGPVTRHGPDSKCDSIVFPQHPWPFGSTSSSDEGDDDGEDHVDAQDIYDLISTISDPEHPHTLGQLSVVRLPDIHLDPSPAVLPDPDSLVTVLVELTPTINHCSLATVIGLAVRCRLEQTLPPNYRVDVRMKDGSHAQDDQVNKQLGDKERVAAALENDTLQRMVDKMLETCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFD7</accession>
    <name>Q2HFD7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_01067</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220288.1">
        <property type="nucleotide sequence ID" value="XM_001220287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFD7"/>
    <dbReference type="STRING" id="306901.Q2HFD7"/>
    <dbReference type="GeneID" id="4386462"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01067"/>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_2_1_1"/>
    <dbReference type="InParanoid" id="Q2HFD7"/>
    <dbReference type="OMA" id="CNKIVAP"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF112">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G02370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="72"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ92832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="298" mass="31865" checksum="734501B32B59CD30" modified="2006-03-21" version="1">MATFSRLVRFLARDGRTYYGDAILPRGISDISKARQARIITGDIFGKHDVTDQVADIRTLLAPLAPEDVRTVRCLGLNYAAHAKESNMPIPQYPVIFYKPATSLTGPTDPIPIHPLAQQHTGLDYECELVVVIGKRCADVSEARALDHVLGYAVGNDVSHRDWQLKLGGGQWSLGKGFDGWAPFGPGIVRAVGGGGGVEGGIKDPQGLGIRTRVNGKVVQDSTTADMVFGVARTVAFLSQGTTLMPGDVIFTGTPQGVGMGRKPQVWLKDGDVVEVELDGVGTCTNKVEFSPARDAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFE7</accession>
    <name>Q2HFE7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Uracil-DNA glycosylase</fullName>
            <shortName evidence="7">UDG</shortName>
            <ecNumber evidence="7">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UNG1</name>
        <name evidence="11" type="ORF">CHGG_01057</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="7"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220278.1">
        <property type="nucleotide sequence ID" value="XM_001220277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFE7"/>
    <dbReference type="FunCoup" id="Q2HFE7">
        <property type="interactions" value="266"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HFE7"/>
    <dbReference type="GeneID" id="4386493"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01057"/>
    <dbReference type="eggNOG" id="KOG2994">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032162_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HFE7"/>
    <dbReference type="OMA" id="CPLHKVR"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000007">
        <property type="entry name" value="Uracil-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003589">
        <property type="entry name" value="PRK05254.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="10">
        <location>
            <begin position="121"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="354"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ92822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="393" mass="42432" checksum="8CC333153AAEB6F7" modified="2006-03-21" version="1">MSTLKRKAGAEAGAEAKKAKQGSIMSFFGGPKPSSTSATGAAAPEPTPAKFDKAKWAASITPEQRGLLKLEIDTLHESWFALLKEELLTKEFLELKKFLKREAAAGKTVFPPQEDIYSWSRHTPFSTVKVVILGQDPYHNHNQAHGLAFSVRPPTPAPPSLKNMYIALKNDYAAFTPPPNKAGLLTPWAERGVLMLNTCLTVRAHEANSHSNRGWERFTQRVIDLVAARRARGVVFMAWGTPAGKRVLKVDQKRHLVLKSVHPSPLSAARGYFTCGHFKEANEWLAERYGVSGRVDWSLVEGASVFEGEGEKVVEKKEEEAEGGKGKVEGEVVEEGVVKKVEAVATTAAAAAAAAGVGGDAENKENGEKTVVETKGVVKGEDGDENAAPEVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFU4</accession>
    <name>Q2HFU4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_00910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220131.1">
        <property type="nucleotide sequence ID" value="XM_001220130.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4386388"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00910"/>
    <dbReference type="eggNOG" id="KOG4231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_125_6_1"/>
    <dbReference type="InParanoid" id="Q2HFU4"/>
    <dbReference type="OMA" id="MAYLETA"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07216">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="6">
        <location>
            <begin position="12"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="885"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1249"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="56"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="890"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="926"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1249"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1263"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ92675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1318" mass="149197" checksum="55650AAA0245DE8B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFW4</accession>
    <name>Q2HFW4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAR-17a/AIG1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220111.1">
        <property type="nucleotide sequence ID" value="XM_001220110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFW4"/>
    <dbReference type="STRING" id="306901.Q2HFW4"/>
    <dbReference type="GeneID" id="4386689"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00890"/>
    <dbReference type="eggNOG" id="ENOG502RZDB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062880_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HFW4"/>
    <dbReference type="OMA" id="QHAMNSG"/>
    <dbReference type="OrthoDB" id="419711at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242:SF1">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242">
        <property type="entry name" value="OS02G0130600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="30598" checksum="517C715317A389B3" modified="2006-03-21" version="1">MAGQVFKFGTDLWDPTHRFETSWLLSPWVLFFCRALISLYAFTTLIFVLAWQCAQAETGCAASQASFSFFTSLTYWGLGFYFLVAAIHTFTYARTGAALLDRFPRPLQALHSAFYTTVVVYPFIVTIVYWGVLFSGPWFAEVYSGWSNVSQHALNSAFALFELTIPRTDPPPPLHMLWLILVLALYLAVAYITHADKGFYPYSFLDPGEQGPLVAAYVFGIAVGCLIVFGVVWGLIWLRRYVTETRLGKQGKFAKAGRDLSAAGDMEMAKPHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG59</accession>
    <name>Q2HG59_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_00795</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220016.1">
        <property type="nucleotide sequence ID" value="XM_001220015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG59"/>
    <dbReference type="FunCoup" id="Q2HG59">
        <property type="interactions" value="545"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HG59"/>
    <dbReference type="MEROPS" id="T01.012"/>
    <dbReference type="GeneID" id="4386928"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00795"/>
    <dbReference type="eggNOG" id="KOG0175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_7_0_1"/>
    <dbReference type="InParanoid" id="Q2HG59"/>
    <dbReference type="OMA" id="NLGMAMQ"/>
    <dbReference type="OrthoDB" id="37597at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080129">
        <property type="term" value="P:proteasome core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03761">
        <property type="entry name" value="proteasome_beta_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000013">
        <property type="entry name" value="Proteasome subunit beta type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF3">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ92560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="283" mass="31253" checksum="1445033771D64798" modified="2006-03-21" version="1">MDTLVARYSRPAYHQNEVFSEQEQQDLNDTVPSLKFAMPPVAHPSAWLRAATDDRSNPSCPIKIAHGTTTLAFRFQGGIIVATDSRATAGNWIASQTVKKVIEINSDLLGTMAGGAADCQYWLAWLGMQCRLHELRHKRRISVAAASKILANLVYQYKGMGLSMGTMCAGVTKEEGAALYYIDSDGTRLAGDLFCVGSGQTFAYGVLDSEYRWDLTTEEALELGSRSILAATHRDAYSGGFINLYHVKETGWEKHGFTDTNPVFWKTKLEKGEFSNVTSNFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGD2</accession>
    <name>Q2HGD2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_00722</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-nitrosoglutathione + NADH + H(+) = S-(hydroxysulfenamide)glutathione + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:78371"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:145544"/>
            <dbReference type="ChEBI" id="CHEBI:229723"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="12"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219943.1">
        <property type="nucleotide sequence ID" value="XM_001219942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGD2"/>
    <dbReference type="FunCoup" id="Q2HGD2">
        <property type="interactions" value="682"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HGD2"/>
    <dbReference type="GeneID" id="4386763"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00722"/>
    <dbReference type="eggNOG" id="KOG0022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_14_0_1"/>
    <dbReference type="InParanoid" id="Q2HGD2"/>
    <dbReference type="OMA" id="SCYIGCG"/>
    <dbReference type="OrthoDB" id="417550at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033833">
        <property type="term" value="F:hydroxymethylfurfural reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106322">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106321">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080007">
        <property type="term" value="F:S-nitrosoglutathione reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000947">
        <property type="term" value="P:amino acid catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033859">
        <property type="term" value="P:furaldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="18"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ92487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="381" mass="40638" checksum="6B8F39CDA2A066FA" modified="2006-03-21" version="1">MASTVGKTITCKAAIAWGPGKDLSYEDVEVLPPRAHEVRIKIEYTGVCHTDAYTLSGKDPEGAFPVILGHEGAGTVESVGEGVTNVKPGDHVVALYTPECKECKFCKSNKTNLCGKIRATQGKGVMPDGTSRFRARGQDILHFMGTSTFSQYTVVADISVVAVQQDAPMDRTCLLGCGITTGYGAARITARVEEGSNVAVFGAGCVGLSVVQGAVAQKAGKIIVVDVNPAKEEWARRFGATDFVNPAQLPEGKSVVDRLIEMTDGGCDYTFDCTGNVSVMRAALEACHKGWGESIIIGVAAAGQEIATRPFQLVTGRVWRGSAFGGVKGRSQLPDLVTDYLEGRLKVDEFITHRKTLPEINDAFEVMKQGDCIRAVLNMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGK6</accession>
    <name>Q2HGK6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_00648</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219869.1">
        <property type="nucleotide sequence ID" value="XM_001219868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGK6"/>
    <dbReference type="STRING" id="306901.Q2HGK6"/>
    <dbReference type="GeneID" id="4386698"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00648"/>
    <dbReference type="eggNOG" id="ENOG502QTTC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010577_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGK6"/>
    <dbReference type="OMA" id="FYMGVDY"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209167" description="GH16 domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="25"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="582"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="637"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ92413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="705" mass="74066" checksum="34313A296731B5E2" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGL4</accession>
    <name>Q2HGL4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219861.1">
        <property type="nucleotide sequence ID" value="XM_001219860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGL4"/>
    <dbReference type="GeneID" id="4387194"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00640"/>
    <dbReference type="eggNOG" id="ENOG502RJ5U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_711721_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGL4"/>
    <dbReference type="OrthoDB" id="3910171at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="388" mass="42169" checksum="48C254B1FDB675AC" modified="2006-03-21" version="1">MDARLAYGSRPGPAPPREGTDGVQVQVQVLPEENATEEEEAQPTPTLGPGPQSGELQQQQAPYLHFQPSHTPQISNLGLPPPTDADRTVSPGRTVERLARKLSKQDLQQRHQSRTRHRQRQTKQPTPLSPASTTSVQTQAPELRRFQAWAAHDANCQSPLPPPTPSENHAIPCLPIPALGVGEPIEIDEAYVEPEQPEDRRLLDVRRPRRQTSGQLRPSARPVDHRLEGMIADGTQCNVRSEPQPILTPTPMPAPSLPKSGLQLADPGFIEPDPECATADPGIEIDETDPGDMSAFRDELLALAEGNTIPLRYAAGPGGVRKYTVGGVALRYRLSADVAMRCANVVRSRPRMRKRAKSRYGSATTSAVTSPAMSSAQSPPLPPTEFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGZ1</accession>
    <name>Q2HGZ1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CHGG_00513</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219734.1">
        <property type="nucleotide sequence ID" value="XM_001219733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGZ1"/>
    <dbReference type="FunCoup" id="Q2HGZ1">
        <property type="interactions" value="133"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HGZ1"/>
    <dbReference type="GeneID" id="4387808"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00513"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003731_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGZ1"/>
    <dbReference type="OMA" id="WGDSNRI"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007234">
        <property type="term" value="P:osmosensory signaling via phosphorelay pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000004">
        <property type="entry name" value="Ethylene receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000289">
        <property type="entry name" value="Osmosensing histidine protein kinase SLN1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2C_system_His_kinase"/>
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        <property type="entry name" value="CheY-like_superfamily"/>
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        <property type="entry name" value="HATPase_C_sf"/>
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        <property type="entry name" value="His_kinase_dom"/>
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    </dbReference>
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        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TWO-COMPONENT SYSTEM PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 14" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="17">
        <location>
            <begin position="575"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="18">
        <location>
            <begin position="996"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="442"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="744"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="907"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1119"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="448"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="752"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="771"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="788"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="909"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="14">
        <location>
            <position position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAQ92278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1172" mass="127888" checksum="2EA9D960CA18CBD7" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH60</accession>
    <name>Q2HH60_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_00444</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219665.1">
        <property type="nucleotide sequence ID" value="XM_001219664.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2HH60">
        <property type="interactions" value="696"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HH60"/>
    <dbReference type="GeneID" id="4388230"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00444"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003712_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HH60"/>
    <dbReference type="OMA" id="IAKRSWG"/>
    <dbReference type="OrthoDB" id="2215036at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042565">
        <property type="term" value="C:RNA nuclear export complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045478">
        <property type="entry name" value="Exportin-5_C"/>
    </dbReference>
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        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF3">
        <property type="entry name" value="EXPORTIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Exportin-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="43"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1231"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1259"/>
            <end position="1271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ92209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1292" mass="144296" checksum="F1A989AC57A78B17" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHC3</accession>
    <name>Q2HHC3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_00381</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219602.1">
        <property type="nucleotide sequence ID" value="XM_001219601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHC3"/>
    <dbReference type="STRING" id="306901.Q2HHC3"/>
    <dbReference type="GeneID" id="4387947"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00381"/>
    <dbReference type="eggNOG" id="KOG0762">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_16_1_1"/>
    <dbReference type="InParanoid" id="Q2HHC3"/>
    <dbReference type="OMA" id="WVTATPF"/>
    <dbReference type="OrthoDB" id="193856at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="113"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="268"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="146"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ92146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="40304" checksum="1EB54E144AD3A71B" modified="2006-03-21" version="1">MSADFWAGYISGAAGIILGNPLDVLKVRLQAGITTPSPSPSSPLTPPSAAPSTSRAYSYARPFLLGTAAPVLGYGALNALLFVSYNRTEAFLNQLSRCNTGGSTPQDTQARGTNLLTTWLAGAVGGLATWAVSTPTELVKCRAQLQIPTSPPPPPPPPHRHTHPTPNHRPPPTTSTTTTSSWHITKHLLQQHGPRALYAGGAVTALRDTIGYGFYFWGYELCSRAMRGFVLSSPTSGAAAGTVSGMGGGDGGGGGGGNSGGGGEGMGMEAARVLLCGGLAGIITWASIFPLDVVKTRVQTQFLGGERAPLLGGGGGGEGGGRPLGAWEVARQTYREGGVRPFFRGLGVCSVRAFIVNAVQWAVYEWVMAELGQGRREARESQEGGFIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHQ8</accession>
    <name>Q2HHQ8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ketosynthase family 3 (KS3) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_00246</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219467.1">
        <property type="nucleotide sequence ID" value="XM_001219466.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4387182"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00246"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_31_4_1"/>
    <dbReference type="InParanoid" id="Q2HHQ8"/>
    <dbReference type="OMA" id="WEHKNNG"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025363">
        <property type="entry name" value="DUF4267"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF50">
        <property type="entry name" value="HIGHLY REDUCING POLYKETIDE SYNTHASE SRDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14087">
        <property type="entry name" value="DUF4267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2128"/>
            <end position="2150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2177"/>
            <end position="2197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2231"/>
            <end position="2249"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="51"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ92011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="2260" mass="242152" checksum="006F8E5BBE8C386D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHV5</accession>
    <name>Q2HHV5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_00199</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219420.1">
        <property type="nucleotide sequence ID" value="XM_001219419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHV5"/>
    <dbReference type="GeneID" id="4387499"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00199"/>
    <dbReference type="eggNOG" id="ENOG502RDNH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1412006_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHV5"/>
    <dbReference type="OMA" id="WNDSRSK"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF13">
        <property type="entry name" value="RTA1 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208980" evidence="6">
        <location>
            <begin position="18"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ91964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="195" mass="21195" checksum="832E4D89C462CAB2" modified="2006-03-21" version="1">MTLFLPFTCALLAAGYATRSYGTYHNDDPQVYTASLLLIYAAPPLLQLTNHLILTRLFHFVPYFAPIHPHRTLIIFSALTAAIELLTIAGVAYITDRTAPDKSLGIGDTLTKASLVVQLIVVAAFLLLAGVFYGSCRGGRIRNARVVRPLPVAVNVEHPAGYLPENPCMYLAQNGKTILKGPGWNDSRSKTGDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHX7</accession>
    <name>Q2HHX7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tryptophan synthase beta chain-like PALP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219398.1">
        <property type="nucleotide sequence ID" value="XM_001219397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHX7"/>
    <dbReference type="STRING" id="306901.Q2HHX7"/>
    <dbReference type="GeneID" id="4387613"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00177"/>
    <dbReference type="eggNOG" id="KOG1481">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_973185_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHX7"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="2">
        <location>
            <begin position="61"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="286" mass="31204" checksum="45A9ABA70DC26AFE" modified="2006-03-21" version="1">MDASNNVFRGTSAVADFFDPDKNPPLPLVEIPDRLNPYRQDGVRIYAKMLTHLPAQNVKSLPVGTGGCITGTASYLKSQKPSCRILGVFNVFGDPTPGPRHFQGFNTCGFPWTQNVDTFVEVPSTDSFRMSMKLTREGLIAGPSSGQALKGLLDHIGQLKEAGTIAELADPTTGEVSCVFTYSYRCDQARHDERWILEPAQAAAMLRLNDPPELLPPHKDETTISSASLDSSIQATHLPATPTTLTNRPPTLWSTLQILPRRASSTPTTPQTTPNHHNHQQPTTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHY7</accession>
    <name>Q2HHY7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219388.1">
        <property type="nucleotide sequence ID" value="XM_001219387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHY7"/>
    <dbReference type="GeneID" id="4387856"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00167"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002055_4_0_1"/>
    <dbReference type="InParanoid" id="Q2HHY7"/>
    <dbReference type="OMA" id="AWITHTR"/>
    <dbReference type="OrthoDB" id="5242358at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="898" mass="100937" checksum="92301FC30696A902" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHZ5</accession>
    <name>Q2HHZ5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219380.1">
        <property type="nucleotide sequence ID" value="XM_001219379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHZ5"/>
    <dbReference type="GeneID" id="4387201"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00159"/>
    <dbReference type="HOGENOM" id="CLU_2320111_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHZ5"/>
    <dbReference type="OrthoDB" id="5060480at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208983" description="Hydrophobin" evidence="1">
        <location>
            <begin position="17"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="10448" checksum="0AF4E95472A06A97" modified="2006-03-21" version="1">MKPYFTALLALPAALAVPVAKPRHAIATTATAISPKHRACTLVRLSSPANGPRMETVFTDAYCAQATGGNLSKAVCKSITICKDPLIPETEIGTFYVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI72</accession>
    <name>Q2HI72_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Outer spore wall protein RRT8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219303.1">
        <property type="nucleotide sequence ID" value="XM_001219302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HI72"/>
    <dbReference type="GeneID" id="4387622"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00082"/>
    <dbReference type="eggNOG" id="ENOG502SH72">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062645_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HI72"/>
    <dbReference type="OMA" id="REFWPLF"/>
    <dbReference type="OrthoDB" id="2107885at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005619">
        <property type="term" value="C:ascospore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF1">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN RRT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35826" checksum="347FA19575CD40E7" modified="2006-03-21" version="1">MPSEGLSDSAALLRPVRGAVNYTRRALRAAAYPIRGIWYFLRHPEFYPLFVSRLLPLSIISFLVYLLLFAFAFLPQFLFLLIFHGRAGALINTTVLVLGEGLVVIQGLFEGFFVDECRVDIFDVSHASHVALAEWGRSSQLTTPAQATLINHGLTDLIAPQRVLFLDAPDAVRMLGKPTARAEYQPWSLIQIIELIVFLPLNLVPYVGTIAFIMITGSRLGKLSHHRWFKIRGLDKKETKRELKLRRWEYLWFGTVAMILELVPILSFFFLLTSTAGAAMWAAKMEERARIRVGRPIAHESNTHAAEEGPVYHDDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HID6</accession>
    <name>Q2HID6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrodipicolinate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_00018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219239.1">
        <property type="nucleotide sequence ID" value="XM_001219238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HID6"/>
    <dbReference type="STRING" id="306901.Q2HID6"/>
    <dbReference type="GeneID" id="4387585"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00018"/>
    <dbReference type="eggNOG" id="ENOG502RFPT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HID6"/>
    <dbReference type="OMA" id="ETWERIQ"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF68">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ91783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="35560" checksum="0F035414398E4102" modified="2006-03-21" version="1">MSSTPLIPPKGVFVPSPTFFLPASAGASLKIPQAPVDTETQINHSIFLAKAGITGITILGSTGEAVHLSRSERSDLVSSVRRGLDKAGFPGYPLMAGVLTNGELEDTLQWLDDYAKAGAQWGLVLTPGYFGPSVPQEGLVEWYTLIADRSPIPILVYNYPGVTNGVQVLPETYRALANHPNIVGCKMSHGNVSHHVQVSLDPAINHDQFRVYSGFGNQLGPIVAFGAAGVIDGMAAFYPKTVVQLMKLMLKGDSSPQTQAEIHRLQFAVSQGEEFVMRYGVLGIKEATFRVAGFGNLEGGRLPIRGKLPEGAWEKAKGMFLVEIQDIESSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GLX0</accession>
    <name>Q2GLX0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_11102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408039">
        <property type="protein sequence ID" value="EAQ82866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230224.1">
        <property type="nucleotide sequence ID" value="XM_001230223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GLX0"/>
    <dbReference type="GeneID" id="4397398"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_11102"/>
    <dbReference type="eggNOG" id="ENOG502R6NC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1618809_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GLX0"/>
    <dbReference type="OrthoDB" id="10553049at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ82866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="164" mass="17389" checksum="0AEC0D0A14C668F2" modified="2006-03-21" version="1">MRNLTPEPAGHRGARHCALGRWVYEKGEARAARAAKAASNGAQGYYWLASTALAGMRGPPPRFVRVRCTFPSQAADGPISYIAAFAWCPTVCRGTDDCGEHHPSTAAALAHPPGGQRGIWEDSIQAQGNTPYALEGWAMWVFGGSPYSVQSPPGVPTRLGTPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMG7</accession>
    <name>Q2GMG7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RPEL repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_10837</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226104.1">
        <property type="nucleotide sequence ID" value="XM_001226103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMG7"/>
    <dbReference type="STRING" id="306901.Q2GMG7"/>
    <dbReference type="GeneID" id="4397313"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10837"/>
    <dbReference type="eggNOG" id="ENOG502SC67">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121574_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GMG7"/>
    <dbReference type="OMA" id="ENHLMHR"/>
    <dbReference type="OrthoDB" id="197676at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043451">
        <property type="entry name" value="Myocardin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004018">
        <property type="entry name" value="RPEL_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22793:SF12">
        <property type="entry name" value="MYOCARDIN-RELATED TRANSCRIPTION FACTOR, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22793">
        <property type="entry name" value="MYOCARDIN-RELATED TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02755">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00707">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51073">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ83019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="12895" checksum="5A29A1A881CC3004" modified="2006-03-21" version="1">MADENTKPIDTSPISPGLPNPARKNSLEFHLSHRPDRQELVNKNILPASTAAPGLQAHQKDLEKHMRADSLNEKIAHRPSPETLLKDGVLHDDPRSAEDKYTEAIEEEYAKREGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GML4</accession>
    <name>Q2GML4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_10790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ82972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226057.1">
        <property type="nucleotide sequence ID" value="XM_001226056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GML4"/>
    <dbReference type="STRING" id="306901.Q2GML4"/>
    <dbReference type="GeneID" id="4397361"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10790"/>
    <dbReference type="eggNOG" id="ENOG502QTQH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_362896_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GML4"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF97">
        <property type="entry name" value="ISOAMYL ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="630"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="726"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="640"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="671"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="726"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ82972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="770" mass="82934" checksum="5EEF8719A5F556E7" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMQ8</accession>
    <name>Q2GMQ8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pisatin demethylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_10746</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ82928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226013.1">
        <property type="nucleotide sequence ID" value="XM_001226012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMQ8"/>
    <dbReference type="STRING" id="306901.Q2GMQ8"/>
    <dbReference type="GeneID" id="4397215"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10746"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="InParanoid" id="Q2GMQ8"/>
    <dbReference type="OMA" id="MWLQYYA"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000050">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ82928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="58102" checksum="BCED06268BE1ED32" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMW9</accession>
    <name>Q2GMW9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fructose-2,6-bisphosphate 2-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_10685</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.46" evidence="2"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228612.1">
        <property type="nucleotide sequence ID" value="XM_001228611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMW9"/>
    <dbReference type="FunCoup" id="Q2GMW9">
        <property type="interactions" value="411"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GMW9"/>
    <dbReference type="GeneID" id="4396371"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10685"/>
    <dbReference type="eggNOG" id="KOG0234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006383_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GMW9"/>
    <dbReference type="OMA" id="RWIQERC"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000005">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000644">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="8">
        <location>
            <begin position="13"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="232"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ84281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="443" mass="50773" checksum="2F9947433E21E53B" modified="2006-03-21" version="1">MAPKINGLGIMPEDTRICVVMVGLPARGKSYIAQRAQRYLKWLSVPAATFNVGNYRRENAPHPSADFFDTNNAEGERQRRAAANAAVADMLKWFKSGGVVAILDATNSTKERRKWVLERISSEGIEVIFVESKCDDEELVMANIRDVKATSPDYVGQDPEKAALDFRERIRNYEKVYKSINDDKDEDHLTYLKIMNVGKKVFINRIQDYLQSRVVYFLMNLHIRPRSVWLSRHGESMFNLDGRIGGDATLSHRGEEYALKLPELVRESVGSDRPLTVWTSTLKRTIATARHLPKHYNQLQWKALDELDAGVCDGMTYQEIADQYPEDFQARDEDKYNYRYRGGESYRDVVIRLEPIIMELERSEDILIISHQAVIRCIYAYFMQKTQEDSPWVPVPLHTLMKLTPRAYGTELQSYRANIKAVSTWRGKGSTAKHEDPAPEGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNE9</accession>
    <name>Q2GNE9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Chorismate synthase</fullName>
            <ecNumber evidence="4 8">4.2.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_10505</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the chorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228432.1">
        <property type="nucleotide sequence ID" value="XM_001228431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNE9"/>
    <dbReference type="FunCoup" id="Q2GNE9">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GNE9"/>
    <dbReference type="GeneID" id="4396204"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10505"/>
    <dbReference type="eggNOG" id="KOG4492">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034547_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GNE9"/>
    <dbReference type="OMA" id="MLSINAV"/>
    <dbReference type="OrthoDB" id="1721239at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.150.10:FF:000004">
        <property type="entry name" value="Chorismate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="entry name" value="Chorismate synthase AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003793">
        <property type="entry name" value="PRK05382.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085:SF0">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="Chorismate synthase, AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="402"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ84101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="428" mass="45642" checksum="B472C10BD69E0A0A" modified="2006-03-21" version="1">MSTFGEYFRVTTYGESHCRSVGCIVDGCPPGMELTEDDIQPQMTRRRPGQSAITTPRNEKDRVLIQSGTEFGVTLGTPIGMMVMNEDQRPKDYGNKTMDIYPRPSHADWTYLEKYGVKASSGGGRSSARETIGRVAAGTIAEKYLRLAYGIEIVAFTSSVGNVHLFPPTPEHPSPSTNPKFLSLLQTIDRKGVDSFLPVRCPDETITKKMEATIADFRDREDSIGGTVTCVIRNAPSGLGEPCFDKLEAKLAHAMLSIPATKGFEIGSGFGGCEVPGSTHNDPFISTADVEVPSSVAESGAVKSGVARPKLTTKTNYSGGIQGGISNGAPIYFRIAFKPPATIGQEQRTATYDGASEGVLAAKGRHDPCVVPRAVPIVEAMAALVLMDAVLAQQARHTAKSLLPPLQQTVNSGKPSGNGVTETEMSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNF6</accession>
    <name>Q2GNF6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228425.1">
        <property type="nucleotide sequence ID" value="XM_001228424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNF6"/>
    <dbReference type="GeneID" id="4396791"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10498"/>
    <dbReference type="HOGENOM" id="CLU_1643485_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNF6"/>
    <dbReference type="OrthoDB" id="5422061at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="119"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="161" mass="18407" checksum="AF9F0D7DF731EB72" modified="2006-03-21" version="1">MPPQSILASDAGESRPQLALAAPRQPLQPISANTGTRLPPAAPVKKKPGPKPKSLIDRKVVEKPVKRQQRSYSRERKLQVLTFLLHHKMIQTRQRQQRRRDDLLSFHTSTEDMVGPSRYGLMPKAELVRLCRHYRLKVSGNKASLIERLRAREEQADQGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNT9</accession>
    <name>Q2GNT9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_10365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228292.1">
        <property type="nucleotide sequence ID" value="XM_001228291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNT9"/>
    <dbReference type="FunCoup" id="Q2GNT9">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GNT9"/>
    <dbReference type="GeneID" id="4396842"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10365"/>
    <dbReference type="eggNOG" id="KOG2771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024580_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNT9"/>
    <dbReference type="OMA" id="HEPCVAC"/>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF156">
        <property type="entry name" value="INACTIVE TRNA-SPECIFIC ADENOSINE DEAMINASE-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="198"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ83961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="414" mass="46388" checksum="D7893A0844C7421F" modified="2006-03-21" version="1">MDEGDRSIKRSLAAQDPIVRELLQEDVEHGVLIPLKTTLELRDDYQTGHVLITRTPTKAANPAILMLRSLLPDEIIKGVPHLRRCAKPSDLPAHLKAQFMNESPQSRQIHTGKSNWIYIIVGPENMLNRDEVISALSSVEGMEGEVFLRRIPVPMVSPTSQVQAAMWSQHFWPSLYRKNNPLGPHPSMIARQTDEIADDAAIWMTLAHKVAKESHDAGYGEPMGACVIQRDEGKTTLVALAGDSRWCHQEKTGCTGNPMAHSAMRAISIVAQKLVRAENRKTQTRQKPILEFEAFQDSPIAGDEMKVFELEHPNPDGYLCHGLEMYLTHEPCVMCSMAILHSRMGKVVFRHRMPLTGGLCAEDRGRDHPSLKGADGGRGLGLFWRRELNWSMVAWEWESSGCLKPLRVDRAVHA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-20" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPK5</accession>
    <name>PSF3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>DNA replication complex GINS protein PSF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PSF3</name>
        <name type="ORF">CHGG_10099</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GINS3/PSF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228026.1">
        <property type="nucleotide sequence ID" value="XM_001228025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPK5"/>
    <dbReference type="SMR" id="Q2GPK5"/>
    <dbReference type="FunCoup" id="Q2GPK5">
        <property type="interactions" value="354"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GPK5"/>
    <dbReference type="GeneID" id="4396656"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10099"/>
    <dbReference type="eggNOG" id="KOG1106">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1326230_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPK5"/>
    <dbReference type="OrthoDB" id="10251744at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11713">
        <property type="entry name" value="GINS_A_psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010492">
        <property type="entry name" value="GINS_Psf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055221">
        <property type="entry name" value="PSF3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22466">
        <property type="entry name" value="PSF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000278418" description="DNA replication complex GINS protein PSF3">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="207" mass="22646" checksum="4ADF1EAEB8F224E2" modified="2006-03-21" version="1">MSYYDIDAILTDAEPLKAGTKVNLPLWLAEMLAIANTGDVEGKSFVSFDLPPAMGNDVVQALKADPRAVPLRDHSAHFYGLAIHMMELSEEQELAAALRKTFITRASEVALHAQGPEQDATGRWISIDLIHIDLTRARRLGQLGSRPSNRGLGSASPIPEHCAPHMTKNDELRPLQPADTEVGELLLSLHIELSHPTPTMFSRSDPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQ50</accession>
    <name>Q2GQ50_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_09904</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227831.1">
        <property type="nucleotide sequence ID" value="XM_001227830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQ50"/>
    <dbReference type="GeneID" id="4396077"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09904"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012970_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GQ50"/>
    <dbReference type="OMA" id="AATSHQY"/>
    <dbReference type="OrthoDB" id="4078873at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000335">
        <property type="entry name" value="Siderochrome iron transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000284">
        <property type="entry name" value="Siderophore iron transporter mirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="480"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="78"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ83500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="596" mass="65154" checksum="5FCD73C9FEE6F61F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQ57</accession>
    <name>Q2GQ57_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_09897</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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                <person name="Untereiner W.A."/>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQM4</accession>
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                <person name="Untereiner W.A."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
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            <end position="40"/>
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        <location>
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    </feature>
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        <location>
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            <end position="329"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="EAQ83326.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) = [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + nicotinamide + 3 H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:55708"/>
            <dbReference type="Rhea" id="RHEA-COMP:14264"/>
            <dbReference type="Rhea" id="RHEA-COMP:14265"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:90873"/>
            <dbReference type="ChEBI" id="CHEBI:139151"/>
            <dbReference type="EC" id="2.4.2.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homooctamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">During the catalytic reaction, a sulfide is transferred from Cys-218 to a reaction intermediate, generating a dehydroalanine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the THI4 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.60" evidence="6"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227644.1">
        <property type="nucleotide sequence ID" value="XM_001227643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQN7"/>
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        <property type="interactions" value="724"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GQN7"/>
    <dbReference type="GeneID" id="4396637"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09717"/>
    <dbReference type="eggNOG" id="KOG2960">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053727_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQN7"/>
    <dbReference type="OMA" id="MFPRIVV"/>
    <dbReference type="OrthoDB" id="410463at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160205">
        <property type="term" value="F:cysteine-dependent adenosine diphosphate thiazole synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052837">
        <property type="term" value="P:thiazole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03158">
        <property type="entry name" value="THI4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027495">
        <property type="entry name" value="Sti35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002922">
        <property type="entry name" value="Thi4_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00292">
        <property type="entry name" value="sulfide-dependent adenosine diphosphate thiazole synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43422">
        <property type="entry name" value="THIAMINE THIAZOLE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43422:SF3">
        <property type="entry name" value="THIAMINE THIAZOLE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01946">
        <property type="entry name" value="Thi4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="110"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="297"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="2,3-didehydroalanine (Cys)" evidence="6">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ83313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="329" mass="35321" checksum="C0DEFB03C7E883C2" modified="2006-03-21" version="1">MAPSAISPAQQHAQLAFASKKVKDAAALVEDRTDDGLTKSLNEMMGSWDNFTFAPIRESTVSRAMTRRYFADLDTHAESDIVIVGAGSCGLSAAYTLGTLRPDLRITIIEAGVAPGGGAWLGGQLFSAMVMRKPADVFLREIGVPFDDEGDYVVVKHAALFTSTVMSKVLAMDNVKMFNATTVEDLITRPDEGGAGVRIAGVVTNWTLVSMHHDDQSCMDPNTINAPVIISTTGHDGPFGAFSVKRLVSMKQLEQLEGMRGLDMQRAEDAIVKNTREIVPGLIVGGMELSEIDGANRMGPTFGAMALSGVKAAEEAIRVFDLRKKQNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GR02</accession>
    <name>Q2GR02_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_09602</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227529.1">
        <property type="nucleotide sequence ID" value="XM_001227528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GR02"/>
    <dbReference type="FunCoup" id="Q2GR02">
        <property type="interactions" value="1068"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GR02"/>
    <dbReference type="GeneID" id="4396162"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09602"/>
    <dbReference type="eggNOG" id="KOG2584">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015572_4_0_1"/>
    <dbReference type="InParanoid" id="Q2GR02"/>
    <dbReference type="OMA" id="HFNEPGR"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009442">
        <property type="term" value="P:allantoin assimilation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF2">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="5">
        <location>
            <begin position="72"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase 3" evidence="6">
        <location>
            <begin position="491"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="382"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ83198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="63350" checksum="3804FE5A4138D3DE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GR11</accession>
    <name>Q2GR11_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-binding protein REB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_09593</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227520.1">
        <property type="nucleotide sequence ID" value="XM_001227519.1"/>
    </dbReference>
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    <dbReference type="STRING" id="306901.Q2GR11"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380:SF2">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="571"/>
            <end position="619"/>
        </location>
    </feature>
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            <end position="615"/>
        </location>
    </feature>
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        <location>
            <begin position="618"/>
            <end position="687"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
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        <location>
            <begin position="142"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="442"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="798"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
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        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
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            <end position="824"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1004"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ83189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1035" mass="115153" checksum="2F5128EC9878C517" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GR28</accession>
    <name>Q2GR28_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RTA1 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_09576</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227503.1">
        <property type="nucleotide sequence ID" value="XM_001227502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GR28"/>
    <dbReference type="STRING" id="306901.Q2GR28"/>
    <dbReference type="GeneID" id="4395546"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09576"/>
    <dbReference type="eggNOG" id="ENOG502RZA5">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_3_0_1"/>
    <dbReference type="InParanoid" id="Q2GR28"/>
    <dbReference type="OMA" id="NIMHPGF"/>
    <dbReference type="OrthoDB" id="5384040at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF15">
        <property type="entry name" value="LIPID TRANSPORTER ATNI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="282"/>
            <end position="321"/>
        </location>
    </feature>
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        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ85562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="36044" checksum="AF94CCF68FDC203C" modified="2006-03-21" version="1">MSLNQLTTATRLFRREGEWDGEENCLHVTPGPNGNVPPTACNANYNFDPQFAPAVAVAVLFGTLTAMHILEAIVFKKQNTGYATAWQLLFLLAPLWINAFVYMTFARMVLYWHPEGKITGLKATVIARWFVLADVLSFIVQGAGGLMATPSASADVIRIGLNIYLGGLGLQEFFVLLFCGLMVCFQRQCGRGREFDGKPSWKPLLLGLYAVLVCITIRIIFRIVEFSGGLGDNNPIPFHEEYAYVLDCFPMMLALLVLAVIHPGRYLRGPQSEFIRLSRKEKKALKLQKKAERREEKEAKKRAKKHKMADMSRSDDTSYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRE6</accession>
    <name>Q2GRE6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_09458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227385.1">
        <property type="nucleotide sequence ID" value="XM_001227384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRE6"/>
    <dbReference type="STRING" id="306901.Q2GRE6"/>
    <dbReference type="GeneID" id="4395326"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09458"/>
    <dbReference type="eggNOG" id="ENOG502RD0D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049918_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GRE6"/>
    <dbReference type="OMA" id="FTIINYY"/>
    <dbReference type="OrthoDB" id="10260017at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01543">
        <property type="entry name" value="ANATRNSFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ85444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="308" mass="34918" checksum="AD29E6F0F0899896" modified="2006-03-21" version="1">MSTYTDAQLTRYLSHIGYHGDDARHRAAQDPLGCLTALQHHHMARVPFESLSLHYSRHRLLSLDPQDLFAKVVDRGRGGYCMEVNTLFAVVLRSLGFTLYSVGGRVCGPDGKYKGWDHMVNIVTIAGQRYLVDVGFGSRGALHPVPMIDGHEFVGLAAARGRLDHRRLEEHADPNQRVWMYSVREGKDRPWRTQYHFVETEFLAADFEVMNLRTMTAPQSFFVQSVMCMWTLLDEKQESPVGLLILHRDYVKRQLGAVSEVVKRFQSEEERVKALEKYFGIVLNSEERGGIKGLASELSRSPGTMGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRI0</accession>
    <name>Q2GRI0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_09424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227351.1">
        <property type="nucleotide sequence ID" value="XM_001227350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRI0"/>
    <dbReference type="STRING" id="306901.Q2GRI0"/>
    <dbReference type="GeneID" id="4394799"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09424"/>
    <dbReference type="eggNOG" id="ENOG502T7P9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057715_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRI0"/>
    <dbReference type="OMA" id="IDTIAGC"/>
    <dbReference type="OrthoDB" id="5244958at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ85410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="42453" checksum="074A676FE712F38F" modified="2006-03-21" version="1">MGRRNKKPPPRVYHDGLIPATHDTYQSYPEVVGDDFDQVKHEKSYPELAPPQDDPDQQPPPQPHHQYHQHQQDPPDNQPNHQHAHHPSTILAPPNNNNNNANNNLSHHHSPLSPLSGSNPPHSHSQPPPSSSSAPAPPPLIHPLAGLPRPSGVHSLRQAWSEPGDPEDPHGVLLDADRVAWWKRPVFWVLVVAGAVIVVLAGILGGVASGRVGTALGGVGGAGGRGEGSSGSMPPVANPTCPGSGNRNYTTSVAGAMPKTFRIQCGANYPGGDGILGLRKTGSIDTIAGCFDACARESGCVAAVFSPGDAVECWLKEFVGVVQTGGKAEGMVFGMEVGRCQTVRTTLHTWRVIQQTHASQSSTNNMSSQSESQTEASQSKTPAEGKYPYSLLSFMNADEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRL0</accession>
    <name>Q2GRL0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227321.1">
        <property type="nucleotide sequence ID" value="XM_001227320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRL0"/>
    <dbReference type="GeneID" id="4394965"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09394"/>
    <dbReference type="eggNOG" id="ENOG502TAYX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116843_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRL0"/>
    <dbReference type="OMA" id="AYCNYTF"/>
    <dbReference type="OrthoDB" id="4991875at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640:SF1">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208380" description="AA1-like domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="18132" checksum="BA39750507D87A46" modified="2006-03-21" version="1">MLPDISLLLLAGVMSADAHALPVVAAAAEAEPTTVGVFLGAKREGEYSFDASVIAADAVATTYQIRCQSGHLNMPGFPTTTCDQNDPPWTVTEGPSTMVGILSTAIASVTAVLDETCVIEDRTAAYCNYTFSGESAGTTTSTAYTTIITGELFTAYPVVITAGAEKLPAATDSPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRQ5</accession>
    <name>Q2GRQ5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_09349</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227276.1">
        <property type="nucleotide sequence ID" value="XM_001227275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRQ5"/>
    <dbReference type="STRING" id="306901.Q2GRQ5"/>
    <dbReference type="GeneID" id="4395562"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09349"/>
    <dbReference type="eggNOG" id="KOG1290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_81_1_1"/>
    <dbReference type="InParanoid" id="Q2GRQ5"/>
    <dbReference type="OMA" id="KLLRCQV"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ85335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="201" mass="23233" checksum="6F5DD3D1775EB103" modified="2006-03-21" version="1">MYGRERDYVTLKIFARGHGETCKNEFRTYEVLRKANPSHPGYHYVRTALDTFPIERPGGEHQCLVQEPMWDSWKDLLRRNPSGRFSDVLLKGGLQHLFRALDYLHTQCKLVHTDIKADNILHAIADPEILTSFVDGEMEAPSPRKVINGDPVYMSRRFGLPKEWGRIILSDFWCVVDGDVKRNHNAQPDVYRSPEVMLQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRV3</accession>
    <name>Q2GRV3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227228.1">
        <property type="nucleotide sequence ID" value="XM_001227227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRV3"/>
    <dbReference type="GeneID" id="4394853"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09301"/>
    <dbReference type="eggNOG" id="ENOG502STEY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001248_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRV3"/>
    <dbReference type="OrthoDB" id="3934771at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="54890" checksum="46924C1BC9048C49" modified="2006-03-21" version="1">MFRLKDGLHTLLLTGASGNAAALIGGVTLHSATNIGFEGKNEVARNISEEEKLRWKNMVILIVDEISQVGGLTLAAVDSRLRHSTPFCRPVILLPMPRDRGGQRPESAARHLAAHKLFLQFTTVVILREQVRAAGCPRLRGFLRRLRNGDQTELDFQRLRHRLHTPSCESSFVDGLRAITPLNQDRWDLNMAAVVHCQPPGLFFDAQGMSVVVTRNQFVGLKVVNGAPFKGRRHLPRPRRRHHRPSPSDVTLHLGPPVAVLLSSRRIPPVLAIPGAPERHNLDQEQDRSAIPSHNAGAKKGRWRGKPGFRWVTHRTGSLCTPAFAMTDQKSQGKQFSNVLVNLKGVHSSGTATRPSFMSLYVQLSRAQSEDGLHLFRKPARGDFVEPKNVLDKDMKEAILKLERQGEETRRRFEQDHRHEPWFQEWDAMAESAQATEAADEQAETVRAPPPPRPTCEMLIRGSKMQMTPEFEMLSREVEKEKKAKILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GS08</accession>
    <name>Q2GS08_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6589 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_09246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227173.1">
        <property type="nucleotide sequence ID" value="XM_001227172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GS08"/>
    <dbReference type="GeneID" id="4395581"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09246"/>
    <dbReference type="eggNOG" id="ENOG502S7C8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_455602_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GS08"/>
    <dbReference type="OMA" id="WLMEYAL"/>
    <dbReference type="OrthoDB" id="4774349at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6589" evidence="2">
        <location>
            <begin position="69"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ85232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="599" mass="68775" checksum="D782E8756C8DB1F2" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GS22</accession>
    <name>Q2GS22_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pyridoxamine 5'-phosphate oxidase putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227159.1">
        <property type="nucleotide sequence ID" value="XM_001227158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GS22"/>
    <dbReference type="STRING" id="306901.Q2GS22"/>
    <dbReference type="GeneID" id="4395520"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09232"/>
    <dbReference type="eggNOG" id="ENOG502RRJ9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017006_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GS22"/>
    <dbReference type="OMA" id="DCVRTWT"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815">
        <property type="entry name" value="FAD-BINDING, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815:SF2">
        <property type="entry name" value="FAD-BINDING, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="48609" checksum="60AA8E5841B4573E" modified="2006-03-21" version="1">MATLLDNTNSWHAGERAVHTLLKVPTSGRRNPTTAGLPPSYAHRVAVSPLLAVGTLDDQGRPWTSIWGGERGFAQPVAQGILGVQSLVDRAHDPVVEALLGKAADGEVLQPEDDKVMSALSVDLETRDRVKLAGKMMVGTVTGRPDNSTIAETQLAMIVQESLGNCPKYLNIKDIRAHVPSPQLVSPSLPLPAEALALIQQADMFFLSSTNGQTMDTNHRGGPAGFVRVVSNTPDSVELVYPEYSGNRLYQTLGNLHTNPLIGIAIPNYTTSDVLYLTGSTQLLIGPAAGTLMPHTNLAVKITIHAARLVKDGLPFRGTPGEPSPYNPPVRRLASESPNSLATPPQTTSPTATLTLTRRDLLTPTIARFTFLLRPPNTSHKPPPTTTAAPLRWHPGQHITLSFAAELDMGYSHMREADPQSLNDDFVRTFTISNPPPPHPPSADGDGDGDGGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSJ0</accession>
    <name>Q2GSJ0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226991.1">
        <property type="nucleotide sequence ID" value="XM_001226990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSJ0"/>
    <dbReference type="GeneID" id="4395703"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09064"/>
    <dbReference type="eggNOG" id="ENOG502RG1C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1026723_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSJ0"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846:SF1">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="271" mass="30652" checksum="872584C6CD0427FA" modified="2006-03-21" version="1">MPCPSADEEDEGPPPPSQSHFAKFEHFTPNDAASFDDEFARLASSQQWVPGSQDYTRQRTIAMREELQLHYFSQPQRLDNVDEEELSDEERALQGYQALCHEVGIDPRYSAAECKRDLKNTLVNIVDLIDARRTGKRVEVWNSFEEFRAYTLQDKKRINLGRRRSPQGILLRCCRICQRPDYVEKTENATVLKGRRWSTLGHISALLALKADASCSGGPGVGSGRWVAGWVEKFVLFSTSLCHWHRDSDSCLGLSGSWVSLQEDDASVAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSS0</accession>
    <name>Q2GSS0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_08984</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226911.1">
        <property type="nucleotide sequence ID" value="XM_001226910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSS0"/>
    <dbReference type="STRING" id="306901.Q2GSS0"/>
    <dbReference type="GeneID" id="4395372"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08984"/>
    <dbReference type="eggNOG" id="KOG3056">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011047_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSS0"/>
    <dbReference type="OMA" id="IGFCKAV"/>
    <dbReference type="OrthoDB" id="273123at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040184">
        <property type="entry name" value="Mcm10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055065">
        <property type="entry name" value="OB_MCM10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015408">
        <property type="entry name" value="Znf_Mcm10/DnaG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454:SF11">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22379">
        <property type="entry name" value="OB_MCM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09329">
        <property type="entry name" value="zf-primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM10 OB-fold" evidence="10">
        <location>
            <begin position="329"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger Mcm10/DnaG-type" evidence="9">
        <location>
            <begin position="477"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="202"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="289"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="526"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="702"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
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        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="587"/>
            <end position="607"/>
        </location>
    </feature>
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        <location>
            <begin position="648"/>
            <end position="665"/>
        </location>
    </feature>
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        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="715"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="757"/>
            <end position="769"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ84970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="799" mass="86863" checksum="63483F8BD74C18F0" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSZ9</accession>
    <name>Q2GSZ9_CHAGB</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001226831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSZ9"/>
    <dbReference type="GeneID" id="4395285"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08905"/>
    <dbReference type="eggNOG" id="ENOG502QQ65">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118661_0_0_1"/>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="212" mass="19733" checksum="A507EAB8B34DF48B" modified="2006-03-21" version="1">MPGIPFGAFDNLKGKLKAAFKKRGEKKAAKANPKAEEATAAAPAAAAATTAAATEATKTDTAAAAAPAEAPAAETATAAAPATEAPAAEQKTEETPAPGTFGSPADTPARTLTLSKAVAATETTAAAAAPAAEVTPAPAAAAATPATEAAAAPAATGTVAAPAATEPTPAPAAEAAATETPAAEAPAAEEKKEDAAAAATPAPAAAAPAPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTA6</accession>
    <name>Q2GTA6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-dependent oxidoreductase 2 FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_08798</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001226724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTA6"/>
    <dbReference type="STRING" id="306901.Q2GTA6"/>
    <dbReference type="GeneID" id="4395424"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08798"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_0_1"/>
    <dbReference type="InParanoid" id="Q2GTA6"/>
    <dbReference type="OMA" id="RSNFKDE"/>
    <dbReference type="OrthoDB" id="9993796at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF314">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="6">
        <location>
            <begin position="5"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ84784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="371" mass="39571" checksum="C4DA2B6BA5684998" modified="2006-03-21" version="1">MPLQVIVVGAGIGGLCTAIALRQAGHSVQVLQKSTFTTPQTGAALLLTPNGEHVLSFLGFDHTRARADQMTCWEVLDGASLAALARTDLSDARERFGAPLHTTRTGEGGGDGVGGGGETGRGGGGRGVGMGTARLRMGVRVVGGDAEKGVVELEDGEVLRADLVVAADGLHSVLRGVVLGDEGRDAARATPSGLSAFRFLIPTSMLEGNPHFRELRKVKGKGSTVFADTTHESERHLVWYDCQGGQVQNFVGIHSAHQECAPEGERNPENTRLMLPFGGQGANQAIEDAGALGALLKGVESAAALSERLVLFEQVRRLRASRVQIMSKTRLGKEKEVEEELRQFSDPLNPTRLWYCSKFRTEFESRISVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTB9</accession>
    <name>Q2GTB9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_08785</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226712.1">
        <property type="nucleotide sequence ID" value="XM_001226711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTB9"/>
    <dbReference type="GeneID" id="4395655"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08785"/>
    <dbReference type="eggNOG" id="ENOG502SQDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055859_4_2_1"/>
    <dbReference type="InParanoid" id="Q2GTB9"/>
    <dbReference type="OMA" id="DANCCAA"/>
    <dbReference type="OrthoDB" id="5215637at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208168" description="Mid2 domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="155"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="180"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ84771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="34218" checksum="15F343DDE24E7ADF" modified="2006-03-21" version="1">MKTPLIFLLHLGLLQTCLGKKCYYPGGEEAPGDLPCDTEAEHSPCCAGGKIAGACLANKLCLAKGNPDWYARGSCTDPTFEAPECPKFCLSHEGRGWNLDYCFSQTGSETAFCCEGDANCCAAGRLEIQPAPTHVWALWNGAVSRYDVVTPLGTAKETSAPTSSATSSGTTSDAVEHSSTETTSASTTGTAAGGDRSDATGSANSNSNANSNESTGLSTGAQAGIGVGAAAGALLLAAVAFLWWRMNRMQKAMLVAQQQAAAAYPPPETPAYYSRTPAEKHELMAERPTHELAGQHYYVQGDTRSAELSSQPAYTPVESPAAGRNYGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTD4</accession>
    <name>Q2GTD4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226697.1">
        <property type="nucleotide sequence ID" value="XM_001226696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTD4"/>
    <dbReference type="GeneID" id="4395744"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08770"/>
    <dbReference type="eggNOG" id="ENOG502S9QT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127827_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTD4"/>
    <dbReference type="OrthoDB" id="4751730at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208991" evidence="2">
        <location>
            <begin position="18"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="138" mass="14639" checksum="22E3AD0D8D4CC110" modified="2006-03-21" version="1">MKTSFLALLTFAASVLATPLLASRQLESQADALDQLTELVKVHTANINTTTAAVQDNPTLAQQNEACRRPSPPDFDAINGRPDLGHRPLWPRVSGTTTTTGGGDDACGQDSLIAKVQTLVWEVAGTLKFVIVKLGLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU82</accession>
    <name>Q2GU82_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Indoleamine 2,3-dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_08472</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226399.1">
        <property type="nucleotide sequence ID" value="XM_001226398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GU82"/>
    <dbReference type="FunCoup" id="Q2GU82">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GU82"/>
    <dbReference type="GeneID" id="4395514"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08472"/>
    <dbReference type="eggNOG" id="ENOG502QV6W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010089_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GU82"/>
    <dbReference type="OMA" id="SNKIMEP"/>
    <dbReference type="OrthoDB" id="540174at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.480:FF:000004">
        <property type="entry name" value="Indoleamine 2,3-dioxygenase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF5">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00876">
        <property type="entry name" value="IDO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="383"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="285"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ84458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="56262" checksum="29855D4FEA40570A" modified="2006-03-21" version="1">MLPSIPVLADYGISPTHGFLPDVLPLTRLPDPYYNKWEAIVANLQGLILSRRLRGVVDRLPVLSTIGLEHDAEWRRAYMLLCFMAHGYIWGGDSPSDRLPAPISVPLLEIAEHLEVPPVATYAAVCLWNFKPLFMDEEIDNLENLATLTTFTGSLDESWFYLVSVAMEARGAPIIPLMLTAIAAAREDDATTVTSCLNTFAERVDDLSALLQRMHESCDPHIFYHRIRPFLAGSKNMADAGLPQGVIYEDGSGNETYRQYAGGSNAQSSLFQFFDIVLGIEHRPTGEKKATSGEEAERQGRAPPPNHNFISEMRRYMPGPHARFLGDVQAVANLRGYVERNSANRPLAVAYDACLSMLRSLRDRHIAIVTRYIVIPSREVRARSRSPETTRRRVNLATGSRQRAPGIAYHAEEPDAANGGKKNLKGTGGTALISFLKQARDETGEPAVEEWTKRFMSRRPRAEGQGDFFAGKPEEGAGLEVVADTEEVTMPGLAGSWTMDDDVGGICNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUQ6</accession>
    <name>Q2GUQ6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ87045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225954.1">
        <property type="nucleotide sequence ID" value="XM_001225953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUQ6"/>
    <dbReference type="STRING" id="306901.Q2GUQ6"/>
    <dbReference type="GeneID" id="4394478"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08298"/>
    <dbReference type="eggNOG" id="ENOG502T2IP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2003653_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUQ6"/>
    <dbReference type="OrthoDB" id="5082906at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="124" mass="13690" checksum="C11A5BDFA50F07C6" modified="2006-03-21" version="1">MRHEGLTKAQSSLLSQARIGDIGLRDYLFRVKSPGGPVPPIASAGEAGRRWSTWWFGAPTRRYKGRGTAERFGHIGTYKPVLRGSFGPKLSKPALIESSREALSNHATCTDTQPAARPQWAWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUU5</accession>
    <name>Q2GUU5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_08259</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ87006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225915.1">
        <property type="nucleotide sequence ID" value="XM_001225914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUU5"/>
    <dbReference type="FunCoup" id="Q2GUU5">
        <property type="interactions" value="750"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GUU5"/>
    <dbReference type="GeneID" id="4393337"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08259"/>
    <dbReference type="eggNOG" id="KOG2509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023797_4_3_1"/>
    <dbReference type="InParanoid" id="Q2GUU5"/>
    <dbReference type="OMA" id="EQNCIDR"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000069">
        <property type="entry name" value="Seryl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="276"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="362"/>
            <end position="364"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="378"/>
            <end position="381"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="455"/>
            <end position="458"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="8">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ87006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="534" mass="58937" checksum="DCAC363E95B13473" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWD1</accession>
    <name>Q2GWD1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Urease accessory protein UreF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_07723</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225379.1">
        <property type="nucleotide sequence ID" value="XM_001225378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWD1"/>
    <dbReference type="GeneID" id="4393350"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07723"/>
    <dbReference type="eggNOG" id="ENOG502REVQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049215_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWD1"/>
    <dbReference type="OMA" id="WVGRHEK"/>
    <dbReference type="OrthoDB" id="2550922at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="entry name" value="Urease accessory protein UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="168"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="171"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ86470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="32467" checksum="6F01C7C9C23F6732" modified="2006-03-21" version="1">MILSKVNGESGHEIDDEIADLEQPLSSPLTSPTHFLLLLSDSALPLGSFAFSSGLESYLAHQKVVFGQPSSFASFLPLSISSYASTTLPFVLAAHRDPSLANLTALDDALDAAIVCTVGRRASVAQGRALLSIWERSFAGALAERGTAGGGADVNEALRGFSALLRGCSNSSSSSTTTTTTTPTSTPALTNGDSTPTTTTTPPSPNDDPPLPPPVAAHLGPLFGALCALAGLGLEQTAYVFMVSHVKALVSAAVRAGMFGPYQAQKTLASAGVQGLVAAVVQREWGTPVEEAGQSVPVMDLWVATEYKRPSSPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWI7</accession>
    <name>Q2GWI7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_07667</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225323.1">
        <property type="nucleotide sequence ID" value="XM_001225322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWI7"/>
    <dbReference type="STRING" id="306901.Q2GWI7"/>
    <dbReference type="GeneID" id="4393862"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07667"/>
    <dbReference type="eggNOG" id="KOG1287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_552057_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWI7"/>
    <dbReference type="OMA" id="MATIWAR"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF382">
        <property type="entry name" value="LOW-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ86414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="53348" checksum="E8D41C72B3257CB1" modified="2006-03-21" version="1">MALTSTEDPFIRASLPGRQLECTTWRFSNETEDDKPGRSRDSKTAASVACIVAAETAYELSSYVMRRPERTRFISRPVDDDAADSEGTGETFDYDGLAGIGTEPRQIGVAGAMFLILNKMIGTGIFSTPSSIFAATGSVGISLLLWAVAGLLTLSGLSVYLEFGLAIPRSGGEKNYLERIFRRPRRLATSVFAVQIVLLGFSAGNSLAFGRYVLLAVGHPMPDGWIPRAIAVACMTFVVVLHGVFPKWGLRLTNALGIFKVLVLLLIVFSGFAALAGYRLVPDPHNFDDFWAVEKGDGYGGGGAYAYATALLQVVYSYKGWENANYVMGELKNPQRTLKIAAPLAVVGITVLYVLANVAYFAAIPKRELAKSEVIVAGLFFRNMFGESVAARSLPALVALSNIGNVLALLLHWIVTIIVLLAPPPGPAYNFIVNLYTSPRRPGSTALVGRRPSCTLRPSPRRALVLALADLLARARRLSVLEHLPSRHPLCAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWJ3</accession>
    <name>Q2GWJ3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_07661</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225317.1">
        <property type="nucleotide sequence ID" value="XM_001225316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWJ3"/>
    <dbReference type="GeneID" id="4393892"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07661"/>
    <dbReference type="eggNOG" id="ENOG502QR6D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013783_3_0_1"/>
    <dbReference type="InParanoid" id="Q2GWJ3"/>
    <dbReference type="OMA" id="VTITPDC"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF35">
        <property type="entry name" value="PEPTIDASE S53 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208680" description="tripeptidyl-peptidase II" evidence="16">
        <location>
            <begin position="22"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="17">
        <location>
            <begin position="214"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="552"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="553"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="585"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="587"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ86408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="630" mass="67657" checksum="FFA029F9B839AE84" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWV0</accession>
    <name>Q2GWV0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_07554</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225210.1">
        <property type="nucleotide sequence ID" value="XM_001225209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWV0"/>
    <dbReference type="GeneID" id="4393275"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07554"/>
    <dbReference type="eggNOG" id="KOG2029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1686357_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWV0"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ86301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="156" mass="16827" checksum="274ED7F5CD4FFAE7" modified="2006-03-21" version="1">MSFEYNAQAIASISPAGVRDHAANLVKLLVDEREDLVFFGTPHRGSEAAKWASIVADVASAVLNRPKSQLLEALETNSDDLTEISEDFSPLASRYAIASFYESNVHRGLGTVVVGKASAIMALPHEETFMLGGDHSSMFEDPAFMMKLVIPVGVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWY5</accession>
    <name>Q2GWY5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arylsulfotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225175.1">
        <property type="nucleotide sequence ID" value="XM_001225174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWY5"/>
    <dbReference type="GeneID" id="4394330"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07519"/>
    <dbReference type="eggNOG" id="ENOG502QTSQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018249_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GWY5"/>
    <dbReference type="OMA" id="HAYMDSG"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF9">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209091" description="Arylsulfotransferase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="564" mass="62190" checksum="605E354D753D89D7" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXZ0</accession>
    <name>Q2GXZ0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_07164</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224820.1">
        <property type="nucleotide sequence ID" value="XM_001224819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXZ0"/>
    <dbReference type="STRING" id="306901.Q2GXZ0"/>
    <dbReference type="GeneID" id="4393564"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07164"/>
    <dbReference type="eggNOG" id="KOG0131">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_21_1_1"/>
    <dbReference type="InParanoid" id="Q2GXZ0"/>
    <dbReference type="OMA" id="TARTAMH"/>
    <dbReference type="OrthoDB" id="10259687at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12334">
        <property type="entry name" value="RRM1_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12335">
        <property type="entry name" value="RRM2_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000288">
        <property type="entry name" value="Splicing factor 3b subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000505">
        <property type="entry name" value="Splicing factor 3B subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034158">
        <property type="entry name" value="SF3B4_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034159">
        <property type="entry name" value="SF3B4_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052084">
        <property type="entry name" value="SF3B4_spliceosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030:SF3">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="139"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="227"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="366"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="426"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="452"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="515"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ85911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="529" mass="55089" checksum="4A7CBAE332791EFE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GY14</accession>
    <name>Q2GY14_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_07140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224796.1">
        <property type="nucleotide sequence ID" value="XM_001224795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GY14"/>
    <dbReference type="STRING" id="306901.Q2GY14"/>
    <dbReference type="GeneID" id="4393510"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07140"/>
    <dbReference type="eggNOG" id="KOG3409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067135_3_0_1"/>
    <dbReference type="InParanoid" id="Q2GY14"/>
    <dbReference type="OMA" id="PMVPVGW"/>
    <dbReference type="OrthoDB" id="440760at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019495">
        <property type="entry name" value="EXOSC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE CSL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10447">
        <property type="entry name" value="EXOSC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="6">
        <location>
            <begin position="11"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Exosome complex component CSL4 C-terminal" evidence="5">
        <location>
            <begin position="103"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ85887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="21516" checksum="86BD440A1E443F05" modified="2006-03-21" version="1">MTTTTPAPPTLAIPGQLLGPASRYQPGPGTHLHNANLYASLLGHVHITQPAQQPPRQRAPGPAKRLTKITPAPAPAPTPPAERPTISVAVADAVVAILVCGDSVLEAEWQGLIRVQDVRATEKDRVRIYESFRPGDVVRAEVISLGDQANYYLSTTRNELGVVLAVSEAGNTMQPVSWKEFRDPETGAMELRKVAQPQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYC2</accession>
    <name>Q2GYC2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224688.1">
        <property type="nucleotide sequence ID" value="XM_001224687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYC2"/>
    <dbReference type="GeneID" id="4393226"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07032"/>
    <dbReference type="HOGENOM" id="CLU_1421269_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYC2"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="191" mass="20115" checksum="4157B26DDA8BE13D" modified="2006-03-21" version="1">MGAPAFDWRTGASHNQVAEEAHIHPRPGSAGHGVSEEGSFAAPSTASLPSAHTINKRGCLVAFDAVLDSEGLGTKKVVCNRNVESQLLGFERNWSLSGAMSRAGNAPARWRVRSPSRGPVQNRWADGAGRWHGGSVGLACGGREGWMNLRRPRPAPPAGLGEQVERVPALGALAGFTQCGRLASQPKLQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYM7</accession>
    <name>Q2GYM7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynactin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_06927</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224583.1">
        <property type="nucleotide sequence ID" value="XM_001224582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYM7"/>
    <dbReference type="STRING" id="306901.Q2GYM7"/>
    <dbReference type="GeneID" id="4393981"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06927"/>
    <dbReference type="eggNOG" id="KOG3121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088622_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYM7"/>
    <dbReference type="OMA" id="SQIHGTQ"/>
    <dbReference type="OrthoDB" id="417208at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03359">
        <property type="entry name" value="LbH_Dynactin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047125">
        <property type="entry name" value="DCTN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21711">
        <property type="entry name" value="DCTN5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ85674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="198" mass="21169" checksum="2814B9D68BA2A627" modified="2006-03-21" version="1">MSSRRPPRGEYIETDTGNKVARKATLVGTQNIMLGGKTVIQPEAMIRGDLIRTIQAQPQSGGAAPNNTAVSIGRYCFLSRGCCLRPPGRLYKGAFTFMPLRMGDHVFVGAGSVVQAASVGSHVHIGARVSIGEFAIIKEYVRILDGTVVPPNMVIPSFSIVAGQPARLIGEVPEGGHEAFELRDLYKTVGNNPQPMPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYQ4</accession>
    <name>Q2GYQ4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_06900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224556.1">
        <property type="nucleotide sequence ID" value="XM_001224555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYQ4"/>
    <dbReference type="GeneID" id="4393139"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06900"/>
    <dbReference type="eggNOG" id="KOG1121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_278218_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYQ4"/>
    <dbReference type="OrthoDB" id="6619648at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="506"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1064"/>
            <end position="1089"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ85647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1137" mass="128924" checksum="ACCF094F17101C51" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZ05</accession>
    <name>Q2GZ05_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224455.1">
        <property type="nucleotide sequence ID" value="XM_001224454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZ05"/>
    <dbReference type="STRING" id="306901.Q2GZ05"/>
    <dbReference type="GeneID" id="4393038"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05241"/>
    <dbReference type="eggNOG" id="KOG0514">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_138_0_1"/>
    <dbReference type="InParanoid" id="Q2GZ05"/>
    <dbReference type="OMA" id="CAWNTIN"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="41"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="319"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="384" mass="42231" checksum="07704DB1926A176B" modified="2006-03-21" version="1">MRLLDTLTLDLGDFTDNVPLYAILSHRWSNKEPTLQDSRFCSVAASHGFQYGWVDTCCIDKTSSAELSEAINSMYRWYKDATICFVYLGDVGRDSSMLNSPFLAKRYPGFSNSNWFSRGWTLQEPIAPSMVVFLDDTWQEIDTKYSLRSVLSAITGIPDTILGGASPYTASIAQRMSWASNRETTRVEDTAYSLMGLFDVNMPMLYGEGEKAFLRLQQEIIKTSDDHSIFAWEPPASNSEDGNTGLLATSPAAFAFCGDIVPWDSVNAQNTLSRAISTDNKGIHLKLITALLSAVLREHGAVAKALIDAGADAKAADEAGQTALHYATETGQTEIVKLLLDSGADVEHEDVDGNTALILASQRGYRDVERLLTRNVFDMRATSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H034</accession>
    <name>Q2H034_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zinc transporter YKE4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_04862</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224076.1">
        <property type="nucleotide sequence ID" value="XM_001224075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H034"/>
    <dbReference type="FunCoup" id="Q2H034">
        <property type="interactions" value="143"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H034"/>
    <dbReference type="GeneID" id="4392691"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04862"/>
    <dbReference type="eggNOG" id="KOG2693">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015114_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H034"/>
    <dbReference type="OMA" id="IWLHSIG"/>
    <dbReference type="OrthoDB" id="200954at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950:SF16">
        <property type="entry name" value="ZINC TRANSPORTER ZIP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208797" description="Zinc transporter YKE4" evidence="7">
        <location>
            <begin position="27"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="191"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ88243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="44055" checksum="DB05BEC7DD71F5D9" modified="2006-03-21" version="1">MALLPLRRTRAAAFVLVATFALAAWASTSSTADKTAIPSPDTLSLADLDAQLQECPIITHLSTLKATTHAAHPPSLTTRLFTTLFPSSHPAVNALLATLYISGPPNFLLALCPTNIDPASLSVMVAFAVGGLLGDTLFHLLPEIFLGEDEPDRVRLVLVEPNRNLLLGVAVLVGFLVFVGMDKGLRIATGGAGGHEHGHGGHGHGEGEGRSSAVEGGKDGVRLRKGKKGEVVEAGGKEVEKKEVNPSVKLGGLLNMIADFTHNITDGLAMSASFYASPTISATTTVAVFFHEIPHEVGDFALLVQSGFTKRQAMGAQFVTAIGALLGTLIGIAVQEFGGGGGGGGDADGAAMSMRGGLWGTSLTWGDMLLPFTAGTFLYVGTVAVIPELLETGPNKAAELRKTLVQFAAIFAGAGIMLYISWHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H097</accession>
    <name>Q2H097_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224013.1">
        <property type="nucleotide sequence ID" value="XM_001224012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H097"/>
    <dbReference type="STRING" id="306901.Q2H097"/>
    <dbReference type="GeneID" id="4392439"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04799"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006696_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H097"/>
    <dbReference type="OMA" id="HPHTHES"/>
    <dbReference type="OrthoDB" id="635774at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050167">
        <property type="entry name" value="Ser_Thr_protein_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257">
        <property type="entry name" value="SERINE-THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="218"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="836" mass="94160" checksum="C8E31947B48C6FD2" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-24" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0D3</accession>
    <name>NTE1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Lysophospholipase NTE1</fullName>
            <ecNumber>3.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Intracellular phospholipase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Neuropathy target esterase homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">NTE1</name>
        <name type="ORF">CHGG_04763</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Inhibited by organophosphorus esters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NTE family.</text>
    </comment>
    <comment type="sequence caution" evidence="5">
        <conflict type="frameshift">
            <sequence resource="EMBL-CDS" id="EAQ88144" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="3.1.1.5"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88144.1"/>
        <property type="status" value="ALT_FRAME"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223977.1">
        <property type="nucleotide sequence ID" value="XM_001223976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0D3"/>
    <dbReference type="SMR" id="Q2H0D3"/>
    <dbReference type="FunCoup" id="Q2H0D3">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H0D3"/>
    <dbReference type="GeneID" id="4392000"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04763"/>
    <dbReference type="eggNOG" id="KOG2968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H0D3"/>
    <dbReference type="OrthoDB" id="421051at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000062">
        <property type="entry name" value="Lysophospholipase NTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000007">
        <property type="entry name" value="Lysophospholipase NTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056556">
        <property type="entry name" value="NTE1_P-loop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF29">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE SWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24179">
        <property type="entry name" value="NTE_Ploop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0442">Lipid degradation</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000295316" description="Lysophospholipase NTE1">
        <location>
            <begin position="1"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="118"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="1217"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="315"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="738"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="3">
        <location>
            <begin position="1221"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="3">
        <location>
            <begin position="1248"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="3">
        <location>
            <begin position="1368"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="738"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="1250"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="1368"/>
        </location>
    </feature>
    <feature type="binding site">
        <location>
            <begin position="670"/>
            <end position="789"/>
        </location>
        <ligand>
            <name>a nucleoside 3',5'-cyclic phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58464"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site">
        <location>
            <begin position="837"/>
            <end position="957"/>
        </location>
        <ligand>
            <name>a nucleoside 3',5'-cyclic phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58464"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="1521" mass="167339" checksum="4120EA5A39BDAFF2" modified="2007-07-24" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0P6</accession>
    <name>Q2H0P6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223864.1">
        <property type="nucleotide sequence ID" value="XM_001223863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0P6"/>
    <dbReference type="GeneID" id="4392119"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04650"/>
    <dbReference type="HOGENOM" id="CLU_1686355_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H0P6"/>
    <dbReference type="OrthoDB" id="10470678at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="156" mass="17044" checksum="3D066FCF6CA850DE" modified="2006-03-21" version="1">MAKGLEWNSGNDGAVLQTELGKSLVYWALGHSAGHRFVRPIECIKQRLQCESGAQRNFVDALEVSRTSDDVSVTRLKRQVSGWTGKLPYLALAPATRAGRHAIKGYHRRRAGLDQKLGSGVGWMSKKPRTTADVVQNQPRASRDRGSGTGHSHSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0V4</accession>
    <name>Q2H0V4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_04592</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223806.1">
        <property type="nucleotide sequence ID" value="XM_001223805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0V4"/>
    <dbReference type="GeneID" id="4392745"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04592"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1532364_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H0V4"/>
    <dbReference type="OMA" id="VWEHASA"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ87973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="18279" checksum="B6D94823C77674B3" modified="2006-03-21" version="1">MAEPVGAVEAKVLGFLVFVGLGFGLSAAGGTMLAGAEAPVWEHASAQGIVAQVRIFGGSIGIAASSAILGAKTRGELAGGELPPEMLANLASDPSALSPEQWGSIRRAYTDALHEDMIVCCAVLAAAMVVTLGVYRKNRVSMQEMMKQRYREEGERRRAAKGGSEQRDYPGDAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1G2</accession>
    <name>Q2H1G2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_04384</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223598.1">
        <property type="nucleotide sequence ID" value="XM_001223597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1G2"/>
    <dbReference type="STRING" id="306901.Q2H1G2"/>
    <dbReference type="GeneID" id="4393071"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04384"/>
    <dbReference type="eggNOG" id="ENOG502SING">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031730_4_0_1"/>
    <dbReference type="InParanoid" id="Q2H1G2"/>
    <dbReference type="OMA" id="TCAQVKV"/>
    <dbReference type="OrthoDB" id="6038816at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF2">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208391" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="20"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="17">
        <location>
            <begin position="260"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ87765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="296" mass="32509" checksum="9E0D5A1AD9F8790A" modified="2006-03-21" version="1">MQLTNLALWAVAAVQTVQAHYRWSKLIVNDRLTGDWEYMRENSNGIMPTKQFIQASDDFRCNSGSFANAGRTGVYKVNPGDKIGFQLWYYATMQHPGPLTIHMSKAPNNDVRNYRGDGDWFKVHQMIICKPPSNGYLNDQDWCTWDQSTVSFTLPRDTPPGQYLVRVEHIALHGAKDGHTEFYFECAQIEVGGNGNGQPGPMVKIPGLYDSEDPALRFWIYGVPNYPYTNIGKHSVWTGGQANGGGNSGGGGNTGGGGSGKAPLYGQCGGKDWTGPTSCSEGTCKATNEWYSQCVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2H4</accession>
    <name>Q2H2H4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_04022</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223236.1">
        <property type="nucleotide sequence ID" value="XM_001223235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2H4"/>
    <dbReference type="ESTHER" id="chagb-q2h2h4">
        <property type="family name" value="Hormone-sensitive_lipase_like"/>
    </dbReference>
    <dbReference type="GeneID" id="4391653"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04022"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_340978_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2H4"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="576"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="667"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="807"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="675"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="698"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="715"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ87403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="832" mass="90548" checksum="6FCA38180A70F5B1" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2I0</accession>
    <name>Q2H2I0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_04016</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223230.1">
        <property type="nucleotide sequence ID" value="XM_001223229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2I0"/>
    <dbReference type="GeneID" id="4391534"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04016"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024886_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2I0"/>
    <dbReference type="OMA" id="SEKWIIP"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ87397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="58959" checksum="2405EF90804668AB" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2L8</accession>
    <name>Q2H2L8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CHGG_03978</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223192.1">
        <property type="nucleotide sequence ID" value="XM_001223191.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2H2L8">
        <property type="interactions" value="659"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H2L8"/>
    <dbReference type="GeneID" id="4392073"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03978"/>
    <dbReference type="eggNOG" id="KOG3595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000038_7_0_1"/>
    <dbReference type="InParanoid" id="Q2H2L8"/>
    <dbReference type="OMA" id="LWANECT"/>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000122">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000005">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000071">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000517">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000007">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000004">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000075">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000829">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF36">
        <property type="entry name" value="DYNEIN HEAVY CHAIN, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="41"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="698"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="1040"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2325"/>
            <end position="2358"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1288"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1535"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="2325"/>
            <end position="2337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="2338"/>
            <end position="2349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAQ87359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="2358" mass="265799" checksum="6D2A7669AAFC0D44" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2S1</accession>
    <name>Q2H2S1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="3 8">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_03925</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="3 8"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223139.1">
        <property type="nucleotide sequence ID" value="XM_001223138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2S1"/>
    <dbReference type="STRING" id="306901.Q2H2S1"/>
    <dbReference type="GeneID" id="4392742"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03925"/>
    <dbReference type="eggNOG" id="ENOG502SMCE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025694_2_1_1"/>
    <dbReference type="InParanoid" id="Q2H2S1"/>
    <dbReference type="OMA" id="CGSKWYT"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000033">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF38">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ87306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="423" mass="46337" checksum="024EB85755C38DA0" modified="2006-03-21" version="1">MQFLKSLKPAAATTAVIAALAPKDLDINDPSSIRGVAKTIAGGAMSYYSGTSEKFVDLPEPHYWWQAGALMGSMLDYSHYTGDKTYDQRISRALLAQVGPDFDYMLPTHFGQEGNDDQAFWGFAVMSAAERNFPHPDENVPSWLQLGSNLWNSLTSRWNTTACGGGLLWQIFESNPNGLDYKNTVSNGGLFQISARLARATGNNTYLEWAEKVWDWTEAVGLIDSYGNVYDGASASHNCTDTNPVTFSYSAAIYLYGAAVLADHTGDKKWTQRTERILEASRSFFSPFDNATNIMYEHACEQVFSCNADMRSFKGYFSRFVYGASLFVPSIQPTIDELWHTSALAAAGACSGGADGTTCGQKWYVGGFDGLTGLGEEMCALETIQGLLVGESKPPLKGDEIKVVRTFDSGSKSKRGRYDVRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3A9</accession>
    <name>Q2H3A9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Efficient mitochondria targeting-associated protein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_03737</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM97/sigma-2 receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222951.1">
        <property type="nucleotide sequence ID" value="XM_001222950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3A9"/>
    <dbReference type="STRING" id="306901.Q2H3A9"/>
    <dbReference type="GeneID" id="4392191"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03737"/>
    <dbReference type="eggNOG" id="ENOG502S97I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086812_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H3A9"/>
    <dbReference type="OMA" id="DWLYLFI"/>
    <dbReference type="OrthoDB" id="433124at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051987">
        <property type="entry name" value="Sigma-2_receptor-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016964">
        <property type="entry name" value="Sigma2_recept"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204:SF1">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031032">
        <property type="entry name" value="TMP_97_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="9">
        <location>
            <begin position="9"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ87118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="190" mass="21945" checksum="9C473772FC706833" modified="2006-03-21" version="1">MATYTITWRNKVWMGWFFMQLPIILFMDLLDYMWPAWLYEPVGSPLHAAFQMKAWYIGKYNDPIVQWTAETASGHDSWMGLFMHLEFFFLLPTVLYGIYRLAVQRRGTSGCDELLFFVFALEVAFTTLICIYDTSFLDEAIYPAAIKREMQFQLYAPWCIIPALGAIDMAARIMGRIKAADAAQGAKKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3R0</accession>
    <name>Q2H3R0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222800.1">
        <property type="nucleotide sequence ID" value="XM_001222799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3R0"/>
    <dbReference type="GeneID" id="4390812"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06705"/>
    <dbReference type="HOGENOM" id="CLU_2527250_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3R0"/>
    <dbReference type="OrthoDB" id="10351988at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="84" mass="8842" checksum="821CD96BEF2A513A" modified="2006-03-21" version="1">MKKGKKKWRRHGHGWEPKAPGTGDGSRSKIATAGHTAAHNASVAPGKTAAAWAGTNLGFRSNHIGCSAPSQWSPVKDSVSVRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4F3</accession>
    <name>Q2H4F3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_06462</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222557.1">
        <property type="nucleotide sequence ID" value="XM_001222556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4F3"/>
    <dbReference type="FunCoup" id="Q2H4F3">
        <property type="interactions" value="1015"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H4F3"/>
    <dbReference type="GeneID" id="4391512"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06462"/>
    <dbReference type="eggNOG" id="KOG0378">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060400_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H4F3"/>
    <dbReference type="OMA" id="GHIQLNL"/>
    <dbReference type="OrthoDB" id="1109245at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ89843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="262" mass="29589" checksum="C811984493073E93" modified="2006-03-21" version="1">MGRGPKKHQKRLSAPSHWLLDKLSGVYAPRPSAGPHKLRDCMPLIVFVRNRLKYALNYRETKAIMMQRLVKVDGKVRTDVTYPAGFMDVITIEKTGENFRLVYDTKGRFTVHRIQDEEAKYKLGKVKRVQLGRGGVPFLVTHDARTIRYPDPLIKVNDTVKIDLETGKATDFIKFDTGAIAMVTGGRNMGRVGVITHRERHDGGFNIVHLKDAIDNTFTTRESNVFVIGSEKPWISLPKGKGVKLTIAEERDRKRAATLASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4G7</accession>
    <name>Q2H4G7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_06448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222543.1">
        <property type="nucleotide sequence ID" value="XM_001222542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4G7"/>
    <dbReference type="GeneID" id="4391150"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06448"/>
    <dbReference type="HOGENOM" id="CLU_3068500_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4G7"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="53" mass="5655" checksum="48F4ACB7885D6BEA" modified="2006-03-21" version="1">MRLCTYEKTGCARTSPPFQDSGTENQAAPAGVRGAVLWASRKSVARGPSWADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5L3</accession>
    <name>Q2H5L3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_06052</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222147.1">
        <property type="nucleotide sequence ID" value="XM_001222146.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H5L3"/>
    <dbReference type="GeneID" id="4390289"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06052"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_2_4_1"/>
    <dbReference type="InParanoid" id="Q2H5L3"/>
    <dbReference type="OMA" id="DFAVHIE"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05359">
        <property type="entry name" value="ChcA_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19531">
        <property type="entry name" value="LCL_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1004"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="881"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ89433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1352" mass="147357" checksum="D130C8B51E9E140D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6Y5</accession>
    <name>Q2H6Y5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_05580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221675.1">
        <property type="nucleotide sequence ID" value="XM_001221674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6Y5"/>
    <dbReference type="FunCoup" id="Q2H6Y5">
        <property type="interactions" value="911"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H6Y5"/>
    <dbReference type="GeneID" id="4390792"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05580"/>
    <dbReference type="eggNOG" id="KOG1446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044117_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H6Y5"/>
    <dbReference type="OMA" id="KICVLNG"/>
    <dbReference type="OrthoDB" id="27537at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ88961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="299" mass="32969" checksum="BE12455BDA822E6A" modified="2006-03-21" version="1">MIQLERDCCGQAANGKAAYIRRLALTRLCRSADQFPGPCSRRKTDKDAIRYLATHDNSFIRYFEGHEGTVTNLALHPGADNFISCSVDNTVRIWNIGTKQWTGKLFLNTPYLSAWDPSGNVFAVASPGSGSILLYDYRNYEKAPFSVFDVLKARGPADTEASFRGWTKLEFSNDGKHILLGSRGNGHFLLDSFDGSLKAYLKKPGASTRRLGVGEMEGGNMESSGECCFAPDGRYVISGGKSDLLVWDTLMTPGSDKVLEPAHVLEEKREAAVVAYNPRYNMIASADQDLMFWLPDPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H745</accession>
    <name>Q2H745_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_05520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221616.1">
        <property type="nucleotide sequence ID" value="XM_001221615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H745"/>
    <dbReference type="GeneID" id="4391135"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05520"/>
    <dbReference type="eggNOG" id="ENOG502R0XT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036005_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H745"/>
    <dbReference type="OMA" id="NNWHTDV"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000008">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF9">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE (AFU_ORTHOLOGUE AFUA_3G01010)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="86"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ88902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="379" mass="42189" checksum="2969DE69E83FBCF9" modified="2006-03-21" version="1">MAPAPIFESIVDTVQPKKDTLDLPELARQRLTKAGINLSEGYPYRPAAPLYLQDVYKIRDDERPYEDAGARADKQKTRLFSAATKVTDLTTHIGTEIEGLQLKDLTPEQRDELALLIAERSVVFFRNQDITPQQQKELGEWFGEVEIHPQVPQVPGVAGVTVIWPDLFAQDNAASFRKPGGASSWHTDLVHERQPAGVTHLHNDTVPPVGGDTLWASGYGAYEKLSPEFRKLIDGKQAVYRSAHSYLDRENPTAGPKHIERTHPLVRVHPATGWKALWVNRAMTVRIVGLDKAESDLILNYLYDVFERSVDIQVRFKWTPGTSALWDNRSSISWSMAPSSTCVGRAVPSPTANPMVSRFLACIPSMVSSIDPAATNFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7C3</accession>
    <name>Q2H7C3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_05442</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221537.1">
        <property type="nucleotide sequence ID" value="XM_001221536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7C3"/>
    <dbReference type="FunCoup" id="Q2H7C3">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="GeneID" id="4390891"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05442"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H7C3"/>
    <dbReference type="OMA" id="RIMLWAW"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF14">
        <property type="entry name" value="MFS GENERAL SUBSTRATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ88823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="62781" checksum="083B77EE04823B40" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7R7</accession>
    <name>Q2H7R7_CHAGB</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ88679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001221392.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="4390489"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05298"/>
    <dbReference type="eggNOG" id="ENOG502RHP9">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067171_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7R7"/>
    <dbReference type="OMA" id="WHDAIED"/>
    <dbReference type="OrthoDB" id="4359806at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208603" evidence="2">
        <location>
            <begin position="18"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="270" mass="30904" checksum="63792996E4F184BC" modified="2006-03-21" version="1">MRPSLLLALPLAPLTRAAINWDVYEYGVVPSFQWSRPFPEDGTDPGGFQVLCRHAASFAARMYRLRDLAEAPPAGLAPWRGGIEAFLRAREYVGSWDGVDHKGEDRELVVMEWAEVPERVRAWIEEQRADESEANERRWLFGVFEKPEEKVAGERGEGGGEGQQEAGKASEVASGGDLNNLTKYKPRAGEDHTVLAWPVDHTKPQRDLGKRDITFKIEALSVVETEEGKKSRLMWEKMHRTIKRNERRQQREERQKAKEEIKNGWVRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7V5</accession>
    <name>Q2H7V5_CHAGB</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03699</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001230214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7V5"/>
    <dbReference type="GeneID" id="4389794"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03699"/>
    <dbReference type="eggNOG" id="KOG1121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1098380_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7V5"/>
    <dbReference type="OrthoDB" id="4849884at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="108"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="253" mass="28799" checksum="25F5D45642F20F19" modified="2006-03-21" version="1">MDDEGYQEGLEHWRRKGPIGKLRNIAKFIRASPQRGEAFRNVIQEWDESEDFIFSEASSRELELRQNNATRWNSTYLMIQRAWEKQAEIWAYLWKALYDDPATELAAELASQKPSEPLSPGSGPDAIPRPSPPTTPARDRPARQSRLPQHLQGFEVATPLRQQQQPSHRHPAAAASATAQFNEAALPDHARPAYMARSVSRISSLAADERTYLKEYLEEWYSTVEVEDSLKETPTPSPSPMMSAKRRRIQADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8F1</accession>
    <name>Q2H8F1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_03503</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230019.1">
        <property type="nucleotide sequence ID" value="XM_001230018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8F1"/>
    <dbReference type="STRING" id="306901.Q2H8F1"/>
    <dbReference type="GeneID" id="4388987"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03503"/>
    <dbReference type="eggNOG" id="ENOG502QVJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005679_4_0_1"/>
    <dbReference type="InParanoid" id="Q2H8F1"/>
    <dbReference type="OMA" id="DSHWFRR"/>
    <dbReference type="OrthoDB" id="5405781at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF128">
        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="3">
        <location>
            <begin position="10"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ91568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="451" mass="50813" checksum="EDC5A96E96A8ECF7" modified="2006-03-21" version="1">MSARPSQRNIKWVEGLRGVTSVLVIATHIARALDFPLFWPADYKNGPPRLLQLPYLRIPWQGRIGVPIFAFLTGFVCAYKPVKLAYQQGNQPAALKSVARSAFRRPPRLILPALIATFISFIMSVLGGYTAANRCDSHWVRFDAPDPLPFGENIKRLINTSITTWTNTENLYDRHQWAMRPLLIGAFQVYIVLAATIGMRFKYRMLVHVLMVLYWLINVNALTETFGAMLSLGTLLAELSQHRPTQNLISNHQRLCTYVLAPLIFLIGGYVGSYPAEHEDWAPWSLSLHRFLVNPVDGHRTGSILLDHHSFAVYLTHGTILRTVGMWIVYGISGEPWKPAGKNPDGSQQEQVWLKPKGRPHKMVAILVFTALTYTAAWAWMKWVDTACARATQWLEKKVFEDEDGNEGKDGMAEKGLGHNRGHSRAHSRAFSNGGAQLPRHHDGERSQPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8K1</accession>
    <name>Q2H8K1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229969.1">
        <property type="nucleotide sequence ID" value="XM_001229968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8K1"/>
    <dbReference type="GeneID" id="4389812"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03453"/>
    <dbReference type="HOGENOM" id="CLU_943344_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8K1"/>
    <dbReference type="OrthoDB" id="4585636at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="149"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="295" mass="32883" checksum="A1914E1F5FB23403" modified="2006-03-21" version="1">MADVRQAGVYLQDMAAKPPSSVTTEELLDLAKVCLCRDHHMNRSQMERAVREWVPIIERAKAAYAWAPAPVRPTPAPVKAPVPTFNTRSWQATNWQATLASQAAGFGVANISTQSSQSTTNGAQQQHADAPPGFTARNTAPVKTPEQELAAVQEQLATLRLENTELREKERRLESLVVENSAAKLRKEIERAATQKELSTLQDENRRLLQEQQRLAKLDSEYSAFRKRTEAELAATQERVMELQSQSETLVSSQQEDLELLKAEHSQLLTQLERELETLTVPLQPRILGSPGSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8M5</accession>
    <name>Q2H8M5_CHAGB</name>
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        <recommendedName>
            <fullName evidence="4">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_03429</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229945.1">
        <property type="nucleotide sequence ID" value="XM_001229944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8M5"/>
    <dbReference type="STRING" id="306901.Q2H8M5"/>
    <dbReference type="GeneID" id="4389707"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03429"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_2_12_1"/>
    <dbReference type="InParanoid" id="Q2H8M5"/>
    <dbReference type="OMA" id="GCCCVPG"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF3">
        <property type="entry name" value="SIDEROPHORE SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="280"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ91494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="836" mass="91372" checksum="00FC3215EEFFADC5" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H971</accession>
    <name>Q2H971_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">PQ-loop-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_03233</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the laat-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001229748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H971"/>
    <dbReference type="FunCoup" id="Q2H971">
        <property type="interactions" value="287"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H971"/>
    <dbReference type="GeneID" id="4388909"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03233"/>
    <dbReference type="eggNOG" id="KOG2913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019699_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H971"/>
    <dbReference type="OMA" id="RTTEWKK"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000011">
        <property type="entry name" value="PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF35">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER YPQ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="107"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ91298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="52783" checksum="7A82F1B1609CEFF3" modified="2006-03-21" version="1">MAPPTENLNLDVEAISGICGSISIACWVVVFSPQIIENFRRGSAEGLSIQFVVVWLLGDVFNILGAVLQGVLPTMLILAIYYTIADIVLMVQCFYYRGFTLRDDVTPPAAPPPKSKRNGNGNGNGHHHPGEPSERTRLLAGGRGEGAVSSDNPERSLYHEDHERRGSWTHLSPAVPFVNEEPETMPAPPPTTWTQAVAFNSLAVFMVCAAGVAGWWLSRTYGRGGDGDGKPPSDGQQDLLEFNMLGQVFGWLCAVLYLGSRLPQLLLNWRRKSTEGVSVLFFLFACLGNLTYVLSILAYEPKCAGEEGCQRGEAAQIFWQYILVNLSWLAGSAGTLLLDMSIFVQFFVYSKTEDDQVSDDDESTDEEESIVVPLPSPSSEPSAAAGLPFVISFITPGHADVYDPANRPYTTQNTYNTGRFTDRPHSKNVPTAAPTADTIKHLVTSNRSINHPIATHPAQLATFTNIIATTDGTGLAPSTARAYDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9F9</accession>
    <name>Q2H9F9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229661.1">
        <property type="nucleotide sequence ID" value="XM_001229660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9F9"/>
    <dbReference type="STRING" id="306901.Q2H9F9"/>
    <dbReference type="GeneID" id="4389805"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03145"/>
    <dbReference type="eggNOG" id="ENOG502QT51">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_486587_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9F9"/>
    <dbReference type="OMA" id="FEGSPHQ"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="560" mass="60989" checksum="CBEECBAECB5025C8" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HA83</accession>
    <name>Q2HA83_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Maintenance of mitochondrial morphology protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MMM1</name>
        <name evidence="12" type="ORF">CHGG_02871</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <text evidence="8">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MMM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229387.1">
        <property type="nucleotide sequence ID" value="XM_001229386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HA83"/>
    <dbReference type="FunCoup" id="Q2HA83">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HA83"/>
    <dbReference type="GeneID" id="4389801"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02871"/>
    <dbReference type="eggNOG" id="ENOG502QUUW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032730_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HA83"/>
    <dbReference type="OMA" id="WSFTQGL"/>
    <dbReference type="OrthoDB" id="5599157at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120013">
        <property type="term" value="F:lipid transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015917">
        <property type="term" value="P:aminophospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21671">
        <property type="entry name" value="SMP_Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03103">
        <property type="entry name" value="Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027537">
        <property type="entry name" value="Mmm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019411">
        <property type="entry name" value="MMM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF0">
        <property type="entry name" value="SMP-LTD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10296">
        <property type="entry name" value="MMM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="41"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="117"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="300"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="300"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ90936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="368" mass="41404" checksum="8522C77EF30B8B87" modified="2006-03-21" version="1">MARDVCPTNSEPTLSFTQGFILGQISVVLLIAAFIKFFIFGDPPSPEITASIRAAERRSRTLAHKRSLLSLRESSTRRAGQQPTLNRKKSSILRPSPPPLTIGSILDKTYYKVDSHQPESLDWFNVLVAQTIAQFRSDAQHDDAILTSLTKALNGTSRPDFVDEIRVTELSLGEDFPIFSNCRIIPVDEDGLNLQSAVSVVRFSGTLSISFVPSNPSENTPTKMTFTFLDDYRLDFSIRSLMGSRSRLQDVPKIAQLVESRLHRWFDERCVEPRFQEIALPSMWPRKKNTRGGDEAIADAERSMGKSKGMEMAKEMRTEARREVEAETDVRADRGHESLRYRRRPQTDDSFSTSGSMPGSMPDLDIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAD0</accession>
    <name>Q2HAD0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_02824</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229340.1">
        <property type="nucleotide sequence ID" value="XM_001229339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAD0"/>
    <dbReference type="FunCoup" id="Q2HAD0">
        <property type="interactions" value="559"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HAD0"/>
    <dbReference type="GeneID" id="4388501"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02824"/>
    <dbReference type="eggNOG" id="KOG0989">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042324_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HAD0"/>
    <dbReference type="OMA" id="GCQSGSF"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000011">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000237">
        <property type="entry name" value="replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="66"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ90889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="382" mass="41967" checksum="44D08332F4A18EA0" modified="2006-03-21" version="1">MSNFFDLKARKAAAANGTTSSSTEKQKSETTRVQPWVEKYRPKTLSDVTAQDHTITVLERTLQASNLPHMLFYGPPGTGKTSTILALAKELYGPELMKSRVLELNASDERGISIVREKVKDFARTQLTNPPAGYKTRYPCPPFKIIILDEADSMTQDAQSALRRTMETYSKITRFCLICNYVTRIIDPLASRCSKFRFKSLDQGNARRRLEEIARLEGVPIEDAAVDALIKCSDGDLRKAITFLQSAARLVGASASVAGGEDGEAMDVDKMVTAKVVEDIAGVIPDSTIQALVQAMRPRAAGETYQAIAKVVEEMVADGWSAGQTMTQLHSAVVYDETIPDIQKNKIVMVFSETDKRLVDGADEHLSILDLALRISGIMAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAD7</accession>
    <name>Q2HAD7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_02817</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2005-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Giovannoni S.J."/>
                <person name="Cho J.-C."/>
                <person name="Ferriera S."/>
                <person name="Johnson J."/>
                <person name="Kravitz S."/>
                <person name="Halpern A."/>
                <person name="Remington K."/>
                <person name="Beeson K."/>
                <person name="Tran B."/>
                <person name="Rogers Y.-H."/>
                <person name="Friedman R."/>
                <person name="Venter J.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 148.51</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2006-02" db="EMBL/GenBank/DDBJ databases">
            <title>Annotation of the Chaetomium globosum CBS 148.51 Genome.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Birren B."/>
                <person name="Lander E."/>
                <person name="Galagan J."/>
                <person name="Devon K."/>
                <person name="Nusbaum C."/>
                <person name="Ma L.-J."/>
                <person name="Jaffe D."/>
                <person name="Butler J."/>
                <person name="Alvarez P."/>
                <person name="Gnerre S."/>
                <person name="Grabherr M."/>
                <person name="Kleber M."/>
                <person name="Mauceli E."/>
                <person name="Brockman W."/>
                <person name="Rounsley S."/>
                <person name="Young S."/>
                <person name="LaButti K."/>
                <person name="Pushparaj V."/>
                <person name="DeCaprio D."/>
                <person name="Crawford M."/>
                <person name="Koehrsen M."/>
                <person name="Engels R."/>
                <person name="Montgomery P."/>
                <person name="Pearson M."/>
                <person name="Howarth C."/>
                <person name="Kodira C."/>
                <person name="Yandava C."/>
                <person name="Zeng Q."/>
                <person name="Alvarado L."/>
                <person name="Oleary S."/>
                <person name="Untereiner W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 148.51</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229333.1">
        <property type="nucleotide sequence ID" value="XM_001229332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAD7"/>
    <dbReference type="STRING" id="306901.Q2HAD7"/>
    <dbReference type="GeneID" id="4388621"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02817"/>
    <dbReference type="eggNOG" id="ENOG502SA5X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048021_2_1_1"/>
    <dbReference type="InParanoid" id="Q2HAD7"/>
    <dbReference type="OMA" id="WVKSHTP"/>
    <dbReference type="OrthoDB" id="4585165at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051762">
        <property type="entry name" value="UBF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46318">
        <property type="entry name" value="UPSTREAM BINDING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="244"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="244"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ90882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="316" mass="35630" checksum="632B510056B52532" modified="2006-03-21" version="1">MLSAFGRAAVRQVCVAGSLSIRSAGRLGAPVIPSGYRVVAVFTRGLATAVAPKRTTRATTAAASKKAPAAKKTTSTKKTTTKTAKKPAAKKAVKSKAKPKAKKAAKKPATRKPKKLTDEQKDRIKLRALKERALLKEQPAKLPVTSWNLYLVKNLKERLNKEPKPTFADAIRQLSAEHKALPEQEKEKLDLEAQKNKTANEINLKNWIDSHSVQEIREANVARNLLKRRKSAPTKHTLPDSRFPKGRLTAYMAYVKTRYTSQEFEGLQSKARLSHISSEWKEFNDEQRKPYVDIEKTDRARYEKEMEAYRETIEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAS6</accession>
    <name>Q2HAS6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229194.1">
        <property type="nucleotide sequence ID" value="XM_001229193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAS6"/>
    <dbReference type="GeneID" id="4389203"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02678"/>
    <dbReference type="HOGENOM" id="CLU_745961_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HAS6"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="371" mass="40467" checksum="BDA9225703760BA8" modified="2006-03-21" version="1">MYSRYGPSLNASHSIIGPDFLGFNFGLSIRTETIDTNNATKAAHRTAHGNPIRGIRYWIVAGKMTLPKPVPVAEMASAEDRFVTKYELMTDSGGMKMMPRPNPVHNPWARKICQYSLQRLVMKVPNTTINEPTMIVDFTYPASASLPEKVHIAKARKTYQATSPPSGGWNSSSAKGTASSPPDTEISSSCERIVLVGAAFSTSDPEVMLKSVLSAPNTEALRSGISVDAERGCPCSSGRAEKRACSDGSLLFKSREISTEKGYIRPYFRRHRPHLDVISHAFLVGPTRADQPPDSKSRTDALFPAARLHDSQNRTRKMRAHRSPPLRQGGLRSVRGFWGPYPKRIPGGSSNPTGLPGRTSDDGGRVESGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBT7</accession>
    <name>Q2HBT7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Non-reducing end beta-L-arabinofuranosidase-like GH127 middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228833.1">
        <property type="nucleotide sequence ID" value="XM_001228832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBT7"/>
    <dbReference type="GeneID" id="4388480"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02317"/>
    <dbReference type="eggNOG" id="ENOG502QVKK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016354_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HBT7"/>
    <dbReference type="OMA" id="WERGPYW"/>
    <dbReference type="OrthoDB" id="5358475at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049046">
        <property type="entry name" value="Beta-AFase-like_GH127_middle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20736">
        <property type="entry name" value="Glyco_hydro127M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 middle" evidence="1">
        <location>
            <begin position="232"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="515" mass="57755" checksum="CEA5C2D405FCF257" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-02-08" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBX6</accession>
    <name>LIS11_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nuclear distribution protein PAC1-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lissencephaly-1 homolog 1</fullName>
            <shortName evidence="1">LIS-1 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">nudF homolog 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">PAC1-1</name>
        <name evidence="1" type="synonym">LIS1-1</name>
        <name type="ORF">CHGG_02278</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates. Interacts with NDL1 and dynein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle pole</location>
        </subcellularLocation>
        <text evidence="1">Localizes to the plus ends of microtubules at the hyphal tip and the mitotic spindle poles.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Dimerization mediated by the LisH domain may be required to activate dynein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LIS1/nudF family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228794.1">
        <property type="nucleotide sequence ID" value="XM_001228793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBX6"/>
    <dbReference type="SMR" id="Q2HBX6"/>
    <dbReference type="FunCoup" id="Q2HBX6">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HBX6"/>
    <dbReference type="GeneID" id="4388592"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02278"/>
    <dbReference type="eggNOG" id="KOG0295">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_15_1"/>
    <dbReference type="InParanoid" id="Q2HBX6"/>
    <dbReference type="OMA" id="WHVATKE"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051012">
        <property type="term" value="P:microtubule sliding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000342">
        <property type="entry name" value="Nuclear distribution protein PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03141">
        <property type="entry name" value="lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017252">
        <property type="entry name" value="Dynein_regulator_LIS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037190">
        <property type="entry name" value="LIS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056795">
        <property type="entry name" value="PAC1-like_LisH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24951">
        <property type="entry name" value="LisH_PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037647">
        <property type="entry name" value="Dynein_regulator_Lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109925">
        <property type="entry name" value="Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0493">Microtubule</keyword>
    <keyword id="KW-0498">Mitosis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000405076" description="Nuclear distribution protein PAC1-1">
        <location>
            <begin position="1"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="LisH" evidence="1">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="104"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="147"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3">
        <location>
            <begin position="191"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4">
        <location>
            <begin position="239"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5">
        <location>
            <begin position="283"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 6">
        <location>
            <begin position="344"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 7">
        <location>
            <begin position="388"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="454" mass="49338" checksum="937ADAED133B8D84" modified="2006-03-21" version="1">MAQLLTSRQAEELHRALIAYLSSNNLTSTAAALRAEIGLGEDVFDATTAKKYEGLLEKKWTSVVRLQKKVRHTSQLSNATPTSRQNKDPVNWLPKSPARHTLQSHRQPITCVAFHPVFSSLASGSEDQTIKIWDWELGELERTIKGHTKTVLDVDFGGPRGNTLLASCSSDLTIKLWDPSDDYKNIRTLPGHDHSVSAVRFIPSGVAGGAGNLLVSASRDKTLRIWDVSTGYCVKTLRGHAEWVRDVCPSVDGRFILSTSDDYTSRLWDVSIANPEPKTTLIGHEHVVLCCAIAPSASYPHLAAIAGVKKPPTTSAVEFMATGSRDKTIRLWDARGTCIKILVGHDNWVRGLVFHPGGKYLLSASDDYTLRCWDLTQEGRCVKTISDAHAHFVQCIRWAPSVVKDVSVANGGDGQGGEANGTPRQAAGAGAAEAQIRCVLATGSVDLNVRIFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBY2</accession>
    <name>Q2HBY2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CHGG_02272</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Extracellular metalloprotease that contributes to pathogenicity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228788.1">
        <property type="nucleotide sequence ID" value="XM_001228787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBY2"/>
    <dbReference type="MEROPS" id="M14.014"/>
    <dbReference type="GeneID" id="4388665"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02272"/>
    <dbReference type="eggNOG" id="KOG2650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019326_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HBY2"/>
    <dbReference type="OMA" id="WSYDSGI"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
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        <location>
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            <end position="17"/>
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            <end position="367"/>
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        </source>
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    <sequence length="367" mass="39552" checksum="BD3242E799A9996E" modified="2006-03-21" version="1">MRYSLLVSGGLLALASAASVPSSEKKSYDGYKVVRLTVGEHVAKVQNIVDRLGLTTWKGKPRANADADIVVPPSLIGAFEAEIAGMKAVTMHDDLGASIADEASFSVYAGIEHLQFLDDLHSQYLNQSQVVSAGNSLKGNAITGIHFWGKAGKGKPAVVFHGTVHAREWISTMAQVVEYLAFNLLTTSDNAEVAGFLDKYDFIFFPVVNPDGFIYTQESDRMWRKNRQTTSGSSCIGHDINRNWPYKWSTSGGASSNPCAEDFKGKAEGDAPETVVLADWLKKTQAAQGVKLFIDWHAYSQLLMTPYGYSCTALAPKNDELQSLARGAAAAIKAVNGVSFTTGTHLLHHLQGRAGSSVDYVNDVTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCR1</accession>
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        <recommendedName>
            <fullName evidence="4">Integral membrane protein TmpA</fullName>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    </dbReference>
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    </feature>
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        <location>
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            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ93758.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="56828" checksum="0C2A2472358C4398" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HD66</accession>
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            <fullName evidence="3">PWI domain-containing protein</fullName>
        </recommendedName>
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PWI_dom"/>
    </dbReference>
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        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052225">
        <property type="entry name" value="Ser/Arg_repetitive_matrix"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148:SF0">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="522"/>
        </location>
    </feature>
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        <location>
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            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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            <end position="169"/>
        </location>
    </feature>
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        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
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        <location>
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            <end position="201"/>
        </location>
    </feature>
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        <location>
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            <end position="257"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
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            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
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            <end position="330"/>
        </location>
    </feature>
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        <location>
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            <end position="342"/>
        </location>
    </feature>
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        <location>
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            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="390"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
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        <location>
            <begin position="428"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ93603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="522" mass="58280" checksum="B6900FEE3484A956" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HD74</accession>
    <name>Q2HD74_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Restriction of telomere capping protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_01830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RTC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221051.1">
        <property type="nucleotide sequence ID" value="XM_001221050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HD74"/>
    <dbReference type="GeneID" id="4386962"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01830"/>
    <dbReference type="eggNOG" id="ENOG502SEU0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030573_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HD74"/>
    <dbReference type="OMA" id="HEDQDSI"/>
    <dbReference type="OrthoDB" id="128308at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039024">
        <property type="entry name" value="RTC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028094">
        <property type="entry name" value="RTC4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391:SF1">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14474">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01312">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Restriction of telomere capping protein 4 C-terminal" evidence="9">
        <location>
            <begin position="394"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="23"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ93595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="532" mass="58878" checksum="DDF4B8BA7BFD2DE6" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDA2</accession>
    <name>Q2HDA2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_01802</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221023.1">
        <property type="nucleotide sequence ID" value="XM_001221022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDA2"/>
    <dbReference type="GeneID" id="4386229"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01802"/>
    <dbReference type="eggNOG" id="ENOG502S6JZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069672_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HDA2"/>
    <dbReference type="OMA" id="CEIKWAP"/>
    <dbReference type="OrthoDB" id="2260257at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209138" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="27"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ93567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="241" mass="24386" checksum="64D2ABE305A3308D" modified="2006-03-21" version="1">MRFSITALFAFATAVMAQTEGFNVITKPVKGEKVPAGSTYEIVWQPSAAHPGEITIGLLGGASPQTLSVVDTIAKGVDGEDGTYSWSVPSTLGDLATYGIMITLESDASVFQYGFPFQIVPDESGSESSAEPTATATPTATDDDSETTTTTTKASTKTANTKSVTSTTTVAVPSSTIVSSTVHGNLSTTASPSSTITTSVISESPSQTETSTSSIATNGVASLAAGSFAMLSGVAMAVLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDC5</accession>
    <name>Q2HDC5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60s ribosomal protein L31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_01779</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221000.1">
        <property type="nucleotide sequence ID" value="XM_001220999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDC5"/>
    <dbReference type="FunCoup" id="Q2HDC5">
        <property type="interactions" value="799"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HDC5"/>
    <dbReference type="GeneID" id="4386275"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01779"/>
    <dbReference type="eggNOG" id="KOG0893">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112570_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HDC5"/>
    <dbReference type="OMA" id="EVWKQGI"/>
    <dbReference type="OrthoDB" id="9739313at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020052">
        <property type="entry name" value="Ribosomal_eL31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01144">
        <property type="entry name" value="RIBOSOMAL_L31E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ93544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="122" mass="13882" checksum="78F403369AF7F40B" modified="2006-03-21" version="1">MSSQKPQGKAQRSAIADVVAREYTIHMHKRLHGVSFKKRAPRAIKEIKAFATKAMGTSDVRVDPQLNKKVWEQGVKGVGYRLRIRISRRRNDEEGAKEKLYSYVQAVNVKNPKGLHTVVVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HE19</accession>
    <name>Q2HE19_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sialidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220756.1">
        <property type="nucleotide sequence ID" value="XM_001220755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HE19"/>
    <dbReference type="STRING" id="306901.Q2HE19"/>
    <dbReference type="GeneID" id="4387781"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01535"/>
    <dbReference type="eggNOG" id="ENOG502QW46">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036301_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HE19"/>
    <dbReference type="OMA" id="NPCIWEP"/>
    <dbReference type="OrthoDB" id="2130735at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792">
        <property type="entry name" value="BNR/ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792:SF1">
        <property type="entry name" value="BNR_ASP-BOX REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209154" description="Sialidase domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="44571" checksum="20D241C89764FA6A" modified="2006-03-21" version="1">MKFTLGLGLTAVAFIASLADAQKEPPKEPPKPPPKPPGPKPRPFGTFGENVIWWPDANHTIFYPRITELSDGTVLATAGLDSSPNVFPIFSSSDGGASWKWISNMTDQVNGLGMNAQPALAELPWAVGKFPAGTVLASGNSWARGNSTNIDLYASTDKGHTWEFVSNVARGSGPNTENGNPCIWEPYILPYEGTVGVFYSDQRDPLHAQKLAHQKSTDLVNWGPVVNDVAYKTYTDRPGMTVMAYIPPMKKWILVYEYPGTPSLNASGGESWNGDAYPVYYRLAASPFEFDNDRGYPIVIRGVQPGSSPYVVWSPTGGPNGTIIVSDNDHSDVFTNSFGGQPDRWEAHETPQMNAYSRALLVPAKYPDHLMILGAARYSRTVHRPLSISVVSVKDLLKKKPNDAKPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HE60</accession>
    <name>Q2HE60_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220715.1">
        <property type="nucleotide sequence ID" value="XM_001220714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HE60"/>
    <dbReference type="STRING" id="306901.Q2HE60"/>
    <dbReference type="GeneID" id="4388223"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01494"/>
    <dbReference type="eggNOG" id="ENOG502R9VV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1618804_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HE60"/>
    <dbReference type="OrthoDB" id="61870at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="164" mass="17924" checksum="E4F860BFEF56DCAD" modified="2006-03-21" version="1">MSSPQTILLEDTSTPSPPLLALLQAHLPHSITVLRHLQFARNFPGGHTPSTHILYACHAEEDNNNNSPSQTTTTNTNPPFAVAFVDLSRAPETQISLYSSLERTANEGHHRGQHQNPNHYHLGPPGPPQDEAFPRPSFLPLLRPHTGRGPSSPPPPDGEISFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEC4</accession>
    <name>Q2HEC4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chitin synthesis regulation, Congo red resistance, RCR protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220651.1">
        <property type="nucleotide sequence ID" value="XM_001220650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEC4"/>
    <dbReference type="GeneID" id="4387042"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01430"/>
    <dbReference type="eggNOG" id="ENOG502S8F1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131051_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HEC4"/>
    <dbReference type="OMA" id="YDWGRWV"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020999">
        <property type="entry name" value="Chitin_synth_reg_RCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28187">
        <property type="entry name" value="PROTEIN RCR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28187:SF1">
        <property type="entry name" value="PROTEIN RCR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12273">
        <property type="entry name" value="RCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16904" checksum="250B555E485F25D2" modified="2006-03-21" version="1">MAPFIAQIAELAKRRDGCGSGGYRDYDGDCRYYSSWYWWGRWVFAGLAVLFILLVFAGLFRNSRRRRRQGVQPMYGTGWMAPAPPPYYPPPPQYSAQDQGPPGGYKYGSGDGYYAGNQEGIQLQQPQSAYHRGPEPEYAPPPGPPPTTNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFJ2</accession>
    <name>Q2HFJ2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_01012</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220233.1">
        <property type="nucleotide sequence ID" value="XM_001220232.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2HFJ2">
        <property type="interactions" value="549"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HFJ2"/>
    <dbReference type="GeneID" id="4388049"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01012"/>
    <dbReference type="eggNOG" id="KOG1932">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002317_2_1_1"/>
    <dbReference type="InParanoid" id="Q2HFJ2"/>
    <dbReference type="OMA" id="TDLFMKK"/>
    <dbReference type="OrthoDB" id="308861at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09839">
        <property type="entry name" value="M1_like_TAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000011">
        <property type="entry name" value="Transcription initiation factor TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057345">
        <property type="entry name" value="Ig-like_TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057991">
        <property type="entry name" value="TPR_TAF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25316">
        <property type="entry name" value="TAF2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 Ig-like" evidence="10">
        <location>
            <begin position="605"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 TPR repeats" evidence="11">
        <location>
            <begin position="792"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="263"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1234"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1304"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1234"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1368"/>
            <end position="1377"/>
        </location>
    </feature>
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        <location>
            <begin position="1406"/>
            <end position="1419"/>
        </location>
    </feature>
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        <location>
            <begin position="1477"/>
            <end position="1486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010937"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00017363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00076306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ92777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1486" mass="166396" checksum="01BB7C568A6ACB34" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFL1</accession>
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        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="9" type="ORF">CHGG_00993</name>
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        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF12">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
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        <location>
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            <end position="33"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ92758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="675" mass="74793" checksum="BB22B6BA4379221C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFV5</accession>
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        <recommendedName>
            <fullName evidence="8">Transcription elongation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_00899</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TFS-II family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220120.1">
        <property type="nucleotide sequence ID" value="XM_001220119.1"/>
    </dbReference>
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        <property type="interactions" value="842"/>
    </dbReference>
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    <dbReference type="GeneID" id="4386370"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00899"/>
    <dbReference type="eggNOG" id="KOG1105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037637_1_1_1"/>
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    <dbReference type="OMA" id="RFVVMTH"/>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000001">
        <property type="entry name" value="Probable Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.30:FF:000003">
        <property type="entry name" value="Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035100">
        <property type="entry name" value="TF_IIS-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006289">
        <property type="entry name" value="TFSII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01385">
        <property type="entry name" value="TFSII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006704">
        <property type="entry name" value="TF_IIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="11">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="12">
        <location>
            <begin position="149"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="10">
        <location>
            <begin position="265"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="78"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ92664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="307" mass="34168" checksum="BBB5A3752E4EB8D7" modified="2006-03-21" version="1">MDDQVLSKRVKTLNKAAAAAEPPSVVIALLEELKNAKAPTEEQLRSTKAGVAVGKLRHNANKEIARLASEIVSKWRKNVDAAKESKKRKLEQSKLEQSKSEQSKSPTSPTPKDSPAPPSTSYSTPYEGDPEKRHFRVDKVDISRTGNKTRDGSIGVLYNGLAYRATESIEEVLQRTMEVEAAAYAAYGDTNEYRAKIRGLMTSLKRKDNPELGRRVLRGDIAPEKFAVMTDEELASDAQRERDAALERENMLKAQVPMAQRSISDSLQCGKCKQKKVSYSQAQTRSADEPMTTFCECTVCGHRWKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGA0</accession>
    <name>Q2HGA0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219975.1">
        <property type="nucleotide sequence ID" value="XM_001219974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGA0"/>
    <dbReference type="STRING" id="306901.Q2HGA0"/>
    <dbReference type="GeneID" id="4386675"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00754"/>
    <dbReference type="eggNOG" id="KOG4161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017748_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGA0"/>
    <dbReference type="OrthoDB" id="10265068at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="58561" checksum="A0E9EE962334E302" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGS0</accession>
    <name>Q2HGS0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication factor Cdt1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_00584</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cdt1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219805.1">
        <property type="nucleotide sequence ID" value="XM_001219804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGS0"/>
    <dbReference type="STRING" id="306901.Q2HGS0"/>
    <dbReference type="GeneID" id="4387212"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00584"/>
    <dbReference type="eggNOG" id="ENOG502S8WG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031309_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HGS0"/>
    <dbReference type="OMA" id="WGKRQVT"/>
    <dbReference type="OrthoDB" id="341730at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1420">
        <property type="entry name" value="DNA replication factor Cdt1, C-terminal WH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032054">
        <property type="entry name" value="Cdt1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038090">
        <property type="entry name" value="Cdt1_C_WH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16679">
        <property type="entry name" value="CDT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26121">
        <property type="entry name" value="HTH_CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Cdt1 C-terminal" evidence="4">
        <location>
            <begin position="364"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ92349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="500" mass="54978" checksum="5F81972C5EAEA866" modified="2006-03-21" version="1">MPGVLTRKTRTPRGKLASTTSTATATKFTKVSKQQESGKEARTTTPFTTRSANIEIVLTSRKRKDHDDVESTSKKARRVFESESRIPESSIAPATPISKKRKSVRFSEPEAVPSTPSRAAPTPSSNRKRQRESDETSQAEELLERLNIQSSPVVKRSKTTVHRRAPRNDFDLPKELLDLLDLHSAFLKTLSLQPDSTSASPIDLNTLYTDVTRAWGKRHVGLVDIQRCVGVLAWTPVKSDSAAPRAPYFLTDYGRDKICIEFYPGAERNPLHQHKLKMDFEANLRTLWLSRRDDIPATIFIGTLPKAALKPCALSILAPKTQTTLDAFKQSITEQKQKDQAAKAALLSQTTPPGGAGGQAPKLSLLDRIRLKETLMAQSPSTELSAAEVQRRSALQRAADVAAVVGMLCKATVAAGSGQVRVSFTMAALMGRLKDSMRTPVSQEDGMVCVRLLATEVAPQWLRVVKIGGRENVICMMGLQPTKAEVEERVKVLLGLGFIY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2025-02-05" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGZ8</accession>
    <name>ATG5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Autophagy protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ATG5</name>
        <name type="ORF">CHGG_00506</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Conjugated with ATG12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Conjugated to ATG12; which is essential for autophagy.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219727.1">
        <property type="nucleotide sequence ID" value="XM_001219726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGZ8"/>
    <dbReference type="SMR" id="Q2HGZ8"/>
    <dbReference type="STRING" id="306901.Q2HGZ8"/>
    <dbReference type="GeneID" id="4387819"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00506"/>
    <dbReference type="eggNOG" id="KOG2976">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051894_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HGZ8"/>
    <dbReference type="OMA" id="SIQKAVW"/>
    <dbReference type="OrthoDB" id="272162at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
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        <property type="term" value="C:phagophore assembly site membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:Atg8-family ligase activity"/>
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        <property type="term" value="P:autophagy of mitochondrion"/>
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        <property type="term" value="P:cellular response to nitrogen starvation"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.190">
        <property type="entry name" value="Autophagy protein Apg5, helix rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007239">
        <property type="entry name" value="Atg5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048940">
        <property type="entry name" value="ATG5_HBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042526">
        <property type="entry name" value="Atg5_HR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048939">
        <property type="entry name" value="ATG5_UblA"/>
    </dbReference>
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        <property type="entry name" value="Atg5_UblA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048318">
        <property type="entry name" value="ATG5_UblB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040:SF2">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20637">
        <property type="entry name" value="ATG5_HBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20638">
        <property type="entry name" value="ATG5_UblA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04106">
        <property type="entry name" value="ATG5_UblB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-1017">Isopeptide bond</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0832">Ubl conjugation</keyword>
    <feature type="chain" id="PRO_0000317853" description="Autophagy protein 5">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ATG12)" evidence="1">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="278" mass="30241" checksum="C8D4B2ACD3DF05F1" modified="2006-03-21" version="1">MSSPPASTDHRLVGSTTGAPDTPSAAATPLPQTLWSLQVPLHITHASKSTAPFIVSVPRFSYLALLLPRLTAYYGLPCSSFHHEEIQLRNLAVGLLVDLYQPATLPWRLVVGDGPEWDIADTFTNSAKEADFVRNGNAKQIMSLSKEHSTALWNAVQDNDHVSFGKVNRRLLNTPSPFKNVPIRIYIPSSPNDTGDATPGSFKVVQNLVSPRLPNRAPQTLGAALKSMLPTLFPSSRDPVLANVILHGGPVPFRAPLEELMREAAYPDGWLCLCVVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH74</accession>
    <name>Q2HH74_CHAGB</name>
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        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_00430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219651.1">
        <property type="nucleotide sequence ID" value="XM_001219650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH74"/>
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    </dbReference>
    <dbReference type="STRING" id="306901.Q2HH74"/>
    <dbReference type="GeneID" id="4387301"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00430"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_026447_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HH74"/>
    <dbReference type="OMA" id="GPMNADH"/>
    <dbReference type="OrthoDB" id="1049195at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
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    </dbReference>
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        <property type="term" value="F:mRNA binding"/>
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    </dbReference>
    <dbReference type="CDD" id="cd00590">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000145">
        <property type="entry name" value="Putative RNP domain-containing protein"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RNA-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
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        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
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        <property type="entry name" value="FI21236P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="151"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="270"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="430"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ92195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="530" mass="56781" checksum="24472D01CBEA80E3" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH76</accession>
    <name>Q2HH76_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_00428</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219649.1">
        <property type="nucleotide sequence ID" value="XM_001219648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH76"/>
    <dbReference type="FunCoup" id="Q2HH76">
        <property type="interactions" value="548"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HH76"/>
    <dbReference type="GeneID" id="4387299"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00428"/>
    <dbReference type="eggNOG" id="KOG2141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006786_2_1_1"/>
    <dbReference type="InParanoid" id="Q2HH76"/>
    <dbReference type="OMA" id="FMVDILN"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000050">
        <property type="entry name" value="Nuclear protein (Sgd1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
        <property type="entry name" value="NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="5">
        <location>
            <begin position="665"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="18"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="620"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ92193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="889" mass="98897" checksum="BEA1E6F727AB91D9" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHA8</accession>
    <name>Q2HHA8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome assembly protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_00396</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for efficient biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RSA3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219617.1">
        <property type="nucleotide sequence ID" value="XM_001219616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHA8"/>
    <dbReference type="STRING" id="306901.Q2HHA8"/>
    <dbReference type="GeneID" id="4387312"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00396"/>
    <dbReference type="eggNOG" id="ENOG502SBU9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181714_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HHA8"/>
    <dbReference type="OMA" id="DSKQMSQ"/>
    <dbReference type="OrthoDB" id="69550at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051898">
        <property type="entry name" value="Ribosome_Assembly_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028217">
        <property type="entry name" value="Rsa3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28127">
        <property type="entry name" value="RIBOSOME ASSEMBLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28127:SF1">
        <property type="entry name" value="RIBOSOME ASSEMBLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14615">
        <property type="entry name" value="Rsa3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome-assembly protein 3 C-terminal" evidence="8">
        <location>
            <begin position="15"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ92161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="78" mass="8848" checksum="04E503CD0FE80EAF" modified="2006-03-21" version="1">MAPPQKSDQEIASDFTWYYLQRATQEFAEDLDKVRAADDFKNDSLTIIVSALKQGTALFSPEEQRRIITTAARPESKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHE7</accession>
    <name>Q2HHE7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219578.1">
        <property type="nucleotide sequence ID" value="XM_001219577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHE7"/>
    <dbReference type="GeneID" id="4387778"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00357"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_567400_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHE7"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="54514" checksum="D287C9CECB71BC11" modified="2006-03-21" version="1">MSSPAHPTSPPPVPTDPGPDNDEPLVADDSLASSSTSLASSVMRFRHENGRSYHGWKPERGYILPSDEQESDRLDMQHHIFYLTLDGALHICPAGKEGAPLKRVLDAGTGTGIWAMDFGTAPSETRCPCNLSPGGWLELCDITFPTLCDDGTLSPDAPLSQWNDHVIRAGHMLGHSIESAKHYRQQMLDAGFVNVQSKLYKWPINAWPKDVRYKEIGMWSEHNFCGGMYGLSVALFTRALGWSAEELEVFLVGVRKDLRNRQIHAYWPIKASYLGKAKYFAARLTPGILVKTYGYLSSGLLFSHSDSELSLHDIRLLLTPAVVRWSPDDKPNERKLTDNIKSIYGDDVDPFGLEWQEARTRFMNDQKNCKFRVLQHMEKLLNTHAEHPEYANILNGELPVSRDYLKRMADAAWAEESFYKVWTYMEGRLDFKRSSKLGQYYIRMEAVAIVAIITNCWVEPGGEHGCRLQWLYVAIRRLGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHF8</accession>
    <name>Q2HHF8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219567.1">
        <property type="nucleotide sequence ID" value="XM_001219566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHF8"/>
    <dbReference type="GeneID" id="4387875"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00346"/>
    <dbReference type="eggNOG" id="ENOG502T4IJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153990_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHF8"/>
    <dbReference type="OrthoDB" id="2331623at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209320" evidence="1">
        <location>
            <begin position="17"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="92" mass="9493" checksum="F04C51759BDEB997" modified="2006-03-21" version="1">MKFTLLLTALITAAAAAPAPAAEPAEAGDVSVLATKKWTANGGCKTDWGGRCNAQCIGEAKQKGYKCKDVDSDITGSNCVIGWSTCKCTCFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHG1</accession>
    <name>Q2HHG1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_00343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219564.1">
        <property type="nucleotide sequence ID" value="XM_001219563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHG1"/>
    <dbReference type="GeneID" id="4387872"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00343"/>
    <dbReference type="HOGENOM" id="CLU_1283126_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHG1"/>
    <dbReference type="OrthoDB" id="4575324at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ92108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="215" mass="25686" checksum="99A346E92CE1AA2D" modified="2006-03-21" version="1">MEATMHRPLVIARHRNRISSRIRNPANRSRFTINHNIRPFLNKIKHECGFNSIEDVTNWLKSDEVFPWWQEFRRDCLQQFPPLTTRCKFSSPVTGRVEQRVYHRRAFLSISAVTRLLEDEDLFKKLQRAAGDKRSWAFNCHVAWFVAQVYAKCWDAKRDEGSLCPLVREDWEGDDGRQPWLWVYPLVYTLKYLSVIEERQPGWGVEFGDEDDYFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHG7</accession>
    <name>Q2HHG7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_00337</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219558.1">
        <property type="nucleotide sequence ID" value="XM_001219557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHG7"/>
    <dbReference type="FunCoup" id="Q2HHG7">
        <property type="interactions" value="682"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HHG7"/>
    <dbReference type="GeneID" id="4387701"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00337"/>
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</entry>
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ92010.1"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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            <begin position="442"/>
            <end position="472"/>
        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ92010.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="612" mass="68011" checksum="D9C570F67603B9E6" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHV9</accession>
    <name>Q2HHV9_CHAGB</name>
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        <submittedName>
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        </submittedName>
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    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ91960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001219415.1"/>
    </dbReference>
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    <dbReference type="STRING" id="306901.Q2HHV9"/>
    <dbReference type="GeneID" id="4387602"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00195"/>
    <dbReference type="eggNOG" id="ENOG502RJ75">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_329047_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="134"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="198"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="354"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="457"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="551"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="646"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="963" mass="106991" checksum="7D56A6FC94F8490D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HIB3</accession>
    <name>Q2HIB3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polyketide synthase-like phosphopantetheine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_00041</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219262.1">
        <property type="nucleotide sequence ID" value="XM_001219261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HIB3"/>
    <dbReference type="SMR" id="Q2HIB3"/>
    <dbReference type="STRING" id="306901.Q2HIB3"/>
    <dbReference type="GeneID" id="4386541"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00041"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002220_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HIB3"/>
    <dbReference type="OMA" id="MPMFHAA"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide synthase-like phosphopantetheine-binding" evidence="3">
        <location>
            <begin position="559"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ91806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1044" mass="117275" checksum="0D523EC5B5056201" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-10-17" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q0C718</accession>
    <name>Q0C718_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_11123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH670342">
        <property type="protein sequence ID" value="EAQ82855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230266.1">
        <property type="nucleotide sequence ID" value="XM_001230265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q0C718"/>
    <dbReference type="GeneID" id="4397413"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_11123"/>
    <dbReference type="HOGENOM" id="CLU_2885584_0_0_1"/>
    <dbReference type="InParanoid" id="Q0C718"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ82855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="63" mass="7026" checksum="E5689238152A4B36" modified="2006-10-17" version="1">MAYIYLDHSKVQNLVQTPQEAPQEAPQEAPQEAYQEAPAPQEAVIIESKNKLDSMEAKAESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM99</accession>
    <name>Q2GM99_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226172.1">
        <property type="nucleotide sequence ID" value="XM_001226171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GM99"/>
    <dbReference type="STRING" id="306901.Q2GM99"/>
    <dbReference type="GeneID" id="4397142"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10905"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001613_3_0_1"/>
    <dbReference type="InParanoid" id="Q2GM99"/>
    <dbReference type="OMA" id="AIRIYAW"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="420" mass="46679" checksum="7AAC242B4EB30F0C" modified="2006-03-21" version="1">MPLAVHDTLNTQQRQVYETIMRHFKAKNENRRPPPLRLQIDGGGGTGKSYMVVYGRPSPIVRAAPTGVASNQIGGQTLHSLLRLPVDGDYRSLSETPTTLNALQRRFRGIHYLVGPEPRPGPQHMLGLKTLAWIDQRLREVFPENRDEFFGGPSVILIGDFFQLPPRQQGEDQAPFRRALEELRKADVSVPSWELLASRCSIKLSPEEVDSFADALRIHPTKAQVVEYNHQHMLGLDSPAIQVEAKHEGVEGADVLRDPPEVIMVAFDDYDGPAFTMPNGEPLRSGEKLVVPILRVRQEFMIGANSCSREQFPLLVSYAITVHKSQGITLDKVVCDISAPEFASGLSYVAVSRVKTLGGLMFERPFDRSRIYRETPSRAMGLKLLDHATRRLQALDAVAGVDPSEELSGFISSDEKSVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMF4</accession>
    <name>Q2GMF4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_10850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_352660_0_0_1"/>
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    <dbReference type="OrthoDB" id="4590285at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
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        <property type="entry name" value="RVT_2"/>
    </dbReference>
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        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RVT_2"/>
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    </dbReference>
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        <location>
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            <end position="547"/>
        </location>
    </feature>
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        <location>
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            <end position="264"/>
        </location>
    </feature>
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            <end position="316"/>
        </location>
    </feature>
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            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ83032.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="797" mass="89543" checksum="874F10B55478EBB7" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83029.1"/>
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    </dbReference>
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    <dbReference type="OMA" id="VMTYDMM"/>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:endochitinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:chitin catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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        </location>
    </feature>
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            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ83029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="288" mass="32203" checksum="F93D8005B643712B" modified="2006-03-21" version="1">MASTRFLLPYFLFFFSLTMAGNLTAKSHLRRIMYFTGGNGEDYKQVPNSAKAWEINAYPLLLAELRAALGPDKLISAAVPGLTRDMLAFTRETVPQIMRHLDFLNVMTYDLMNRRDTVTKHHTGVELSLEAIDAYISAGAAPEKLNLGFAFYTKYFKTEHDACAGPSPVGCPTLLLEDPDTGGDLGRSGGFSWHDTVPEEVAESFGRAREHGVYDDQQGGFYYWDAKEDLWWTFDTPDAIKRKFPLIMAKRRLGGVFAWGLGEDAPLFDHFTALSEGLSGHLKARDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN45</accession>
    <name>Q2GN45_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10609</name>
    </gene>
    <organism evidence="3 4">
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228536.1">
        <property type="nucleotide sequence ID" value="XM_001228535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN45"/>
    <dbReference type="STRING" id="306901.Q2GN45"/>
    <dbReference type="GeneID" id="4396526"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10609"/>
    <dbReference type="eggNOG" id="KOG1211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_14_3_1"/>
    <dbReference type="InParanoid" id="Q2GN45"/>
    <dbReference type="OMA" id="FNGRAWG"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="30"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="672" mass="71973" checksum="1E343BE95B632AC5" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN56</accession>
    <name>Q2GN56_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10598</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228525.1">
        <property type="nucleotide sequence ID" value="XM_001228524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN56"/>
    <dbReference type="GeneID" id="4396153"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10598"/>
    <dbReference type="HOGENOM" id="CLU_2426820_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GN56"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="91" mass="9603" checksum="139398E82A846F59" modified="2006-03-21" version="1">MASELLEFSVPIDSSLTEGPGGALANERSRRSESSTLKNGSERIPGEIPKIQVSPRPPSPVPCPFWPVPLRALGINVAGLVFKIGNPPSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN69</accession>
    <name>Q2GN69_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228512.1">
        <property type="nucleotide sequence ID" value="XM_001228511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN69"/>
    <dbReference type="STRING" id="306901.Q2GN69"/>
    <dbReference type="GeneID" id="4396733"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10585"/>
    <dbReference type="HOGENOM" id="CLU_054599_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GN69"/>
    <dbReference type="OrthoDB" id="5134445at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="207" mass="23335" checksum="569FA62992E48554" modified="2006-03-21" version="1">MGGTAYNHQATKTTFLKLYNRKSSDILGCGNGINPWGPAMEIAYIKALQAGAGTIHQFLDDVRHIENPLHDTYHANEVAAYHTLRNFQGELMPRLLEDIDLHLTPPSSPDDELFYVKGIIHVHKHGTASMPRRSPASGHNRDIMVDFGQCRFKAEDESEQDFGKANAAQDEEGNVGVIMRYELKRHAFQLHYMPSGRCDKWKDDDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN77</accession>
    <name>Q2GN77_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_10577</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228504.1">
        <property type="nucleotide sequence ID" value="XM_001228503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN77"/>
    <dbReference type="GeneID" id="4396631"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10577"/>
    <dbReference type="eggNOG" id="KOG0253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_52_4_1"/>
    <dbReference type="InParanoid" id="Q2GN77"/>
    <dbReference type="OMA" id="TWRNYTL"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="53"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ84173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="490" mass="52791" checksum="543E0E28661C7EE3" modified="2006-03-21" version="1">MSTDKNLTEGSQPVDDRHVVGYVSDSMSESSKEQDLLAHHGQDPALSKKMSLVNDVGRASPKLGGYAVDSLVMLLQSVIAGQAYREFGEKGYETAMTIALYAGMFVGSLFWGIGADIIGRKHAFNFSLIICCIATIVAGGMPNWPSLGLFISLIGFGAGGNLVLDTTVFLEFLPGNKQWAITLMALWWGVGQAITGFIAWGFLVPAEWNCASVETCTRGNNMGWRYVMFTSGALVFIMSVLRLTLVKLKETPKYLLSMGEDEKVVETFQSLALKYNRPCGLTVEKLEACGKTANQSESFSIGEMTGHLRGLFTTRKTTLSTLMIWLSWMMIGIVYPLFYAFLPNYLASRGAGAASSARSWPPGCATSPLLGRRYTMLIGALLTAAFFFAYTAVRTADQNVAFSCTIGFCLNIYYGVLFAYTPEVLPSAHRATGNGVAVAGNRIMGALSAVIATEADTSTAAPIFICGALFAGLGVVAAMFPFEPYGRRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN97</accession>
    <name>Q2GN97_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228484.1">
        <property type="nucleotide sequence ID" value="XM_001228483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN97"/>
    <dbReference type="STRING" id="306901.Q2GN97"/>
    <dbReference type="GeneID" id="4395936"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10557"/>
    <dbReference type="eggNOG" id="KOG2965">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1488838_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GN97"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="181" mass="18656" checksum="0C9CB966A3C33297" modified="2006-03-21" version="1">MPPQTLTSLTSLTLISVPYHVGLRASPMHRSHVSEGPDYLKSAGLLSLLLGYGQQHNLPLPLPVHEFEIPPVEDTFEGEIGRTFELIRRVSLAVTAARDAASFPVVLAGNCCISVGVAAGLCGSRELLRAGGCGNGGDDGGGGLGWDCYDGGGVLEGVDGDSARVSAVVVEEGGALWDEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GP01</accession>
    <name>Q2GP01_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228230.1">
        <property type="nucleotide sequence ID" value="XM_001228229.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4396315"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10303"/>
    <dbReference type="eggNOG" id="ENOG502SK1W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_257312_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GP01"/>
    <dbReference type="OrthoDB" id="74545at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01709">
        <property type="entry name" value="RT_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015:SF1">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="120"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="829"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="843"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1356" mass="154810" checksum="5B76818970C497AA" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GP35</accession>
    <name>Q2GP35_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228196.1">
        <property type="nucleotide sequence ID" value="XM_001228195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GP35"/>
    <dbReference type="GeneID" id="4396288"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10269"/>
    <dbReference type="HOGENOM" id="CLU_1959317_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GP35"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ83865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="128" mass="14858" checksum="34AF4DC61D2C0319" modified="2006-03-21" version="1">MTKRKDDRVVGGSARRDRFVMIEDGMLKRDPLRAVVFDFLCSCAARWQMWRTTQPRCWERVMMCSIVGWSIILSSRSGVVVIMECSLQMPDRALTTYRHPPLPRPIAAILRMRCSYSVRLPVVPLSHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GP36</accession>
    <name>Q2GP36_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228195.1">
        <property type="nucleotide sequence ID" value="XM_001228194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GP36"/>
    <dbReference type="GeneID" id="4396287"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10268"/>
    <dbReference type="eggNOG" id="ENOG502RY0F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030370_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GP36"/>
    <dbReference type="OrthoDB" id="10266999at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF267">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="83"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="627" mass="68235" checksum="DDA143C582BE9B6B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPE1</accession>
    <name>Q2GPE1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_10163</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228090.1">
        <property type="nucleotide sequence ID" value="XM_001228089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPE1"/>
    <dbReference type="FunCoup" id="Q2GPE1">
        <property type="interactions" value="984"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GPE1"/>
    <dbReference type="GeneID" id="4396710"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10163"/>
    <dbReference type="eggNOG" id="KOG3283">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080597_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GPE1"/>
    <dbReference type="OMA" id="QRPHYRK"/>
    <dbReference type="OrthoDB" id="1703270at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11380">
        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.168.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.20">
        <property type="entry name" value="Ribosomal protein S8e, subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042563">
        <property type="entry name" value="Ribosomal_protein_eS8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ83759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="202" mass="22683" checksum="F0ABC156D6B5C06C" modified="2006-03-21" version="1">MGISRDSRHKRAATGAKRSQVWKKRAFEAGRQPANTRIGAKRIHTVRTRGGNHKYRALRLDSGNFAWASEGCTRKTRVIGVAYHPSNNELVRTNTLTKSAVIQVDAAPFRQWYEAHYGQPLGRRRQQKQGQAVEEVKKSKSVEAKQAARFAASGKVDSAIEKQFEAGRLYAVVSSRPGQSGRCDGYILEGEELAFYQRKLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPJ7</accession>
    <name>Q2GPJ7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_10107</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228034.1">
        <property type="nucleotide sequence ID" value="XM_001228033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPJ7"/>
    <dbReference type="FunCoup" id="Q2GPJ7">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GPJ7"/>
    <dbReference type="GeneID" id="4396570"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10107"/>
    <dbReference type="eggNOG" id="KOG0872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047036_3_1_1"/>
    <dbReference type="InParanoid" id="Q2GPJ7"/>
    <dbReference type="OMA" id="FVFICPM"/>
    <dbReference type="OrthoDB" id="6354873at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="157"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ83703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="330" mass="38263" checksum="60C2BB20AE81496B" modified="2006-03-21" version="1">MDVALEILDPLVFDKAYAYFNPAKIAPLNGSAHSASIGYGDFASGLSDASASHGSAWARDNIVRQCISILIITQIGATSLYWIFSALSYYFIFDRRLEYHPRFLKNQIRQEIISSMNAVPFINILTLPFFLAEVRGKSMLYTDVSDFGWSWLLISTVLFMVWNDFMIYWIHRLEHHPSIYKYIHKPHHKWIVPTPWAALAFHPLDGYVQSLPYHVFVFICPVQKYLYFFLFGLVQIWTILIHDGDMISGHWLEKFINSPAHHTLHHMYFTVNYGQYFTWADSYFDSHRAPQPELDPLHDALRVMREKGLVDEKGEPIPQPKKGKKGAKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPK3</accession>
    <name>Q2GPK3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228028.1">
        <property type="nucleotide sequence ID" value="XM_001228027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPK3"/>
    <dbReference type="GeneID" id="4396052"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10101"/>
    <dbReference type="HOGENOM" id="CLU_2542373_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPK3"/>
    <dbReference type="OrthoDB" id="425114at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ83697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="83" mass="9201" checksum="4D2B91CF51FB9C3E" modified="2006-03-21" version="1">MSSEAEAQTRQQPTIPVDTGSLRAVLVFGADHYVGEVMVIAALCREIEMSGMAYVVNEVQEPMDFIKRHAPEPGDDRTVWVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQI8</accession>
    <name>Q2GQI8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_09766</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227693.1">
        <property type="nucleotide sequence ID" value="XM_001227692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQI8"/>
    <dbReference type="STRING" id="306901.Q2GQI8"/>
    <dbReference type="GeneID" id="4396587"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09766"/>
    <dbReference type="eggNOG" id="ENOG502RYG3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026792_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQI8"/>
    <dbReference type="OMA" id="GQEQECY"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="61"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ83362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="589" mass="64304" checksum="7C5E5B0F1E8917E9" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQM0</accession>
    <name>Q2GQM0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_09734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227661.1">
        <property type="nucleotide sequence ID" value="XM_001227660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQM0"/>
    <dbReference type="STRING" id="306901.Q2GQM0"/>
    <dbReference type="GeneID" id="4396320"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09734"/>
    <dbReference type="eggNOG" id="ENOG502SKGP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064110_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQM0"/>
    <dbReference type="OMA" id="GWLIWRV"/>
    <dbReference type="OrthoDB" id="5421757at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="387" mass="43342" checksum="45AD2E16B701511D" modified="2006-03-21" version="1">MAPKSKARLTPSTKSTTTSSSSPPHPFKPAPAALQPFCATLPPGHVYITHVDPRPSAAKRKLFLIPIGINLTVIALFVWRVAHITPYYLALAMSMLGHSNETTLQTADLTWAELGWAVARRAATFLLDFVLGVFVWPWPYEFFVGTTGRGSPVAWRWAVGFRDREVYVRRSRDGWDGVLRKEKVDLFDSEAAEAREGRDAILSRVRTATAPMFMQQKTGYLTMNGEWDLDWRGMVDATRLVDSKEIALEAFGTVVLLHHAKFGWVSVDLGNGDNAEQDERRRQVMAFRDALAALGKEDLFFRWVEMIQFETDQPGGFTREKQVVAAQKIRDMFKTNGVDFDGLWKEAVGTDGLAGRVNIKSGLSAVRSQNALVQAARDLEVRYYPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQY2</accession>
    <name>Q2GQY2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227549.1">
        <property type="nucleotide sequence ID" value="XM_001227548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQY2"/>
    <dbReference type="STRING" id="306901.Q2GQY2"/>
    <dbReference type="GeneID" id="4396769"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09622"/>
    <dbReference type="eggNOG" id="ENOG502SR1A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041686_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQY2"/>
    <dbReference type="OMA" id="WAIEIME"/>
    <dbReference type="OrthoDB" id="4186058at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="321" mass="35215" checksum="010830D90D26174F" modified="2006-03-21" version="1">MWSTTTNSKISQNVGPTSPPETPRTASPVFGRKSSPRPGERPPPIPLRPMAPPMSTRQAVNGLNFGHSTAIRPGQLSPRSTSSSSAPSSSSDSSDSEASAPRNATSHSPSAASERPPAPAPPAPEARIGRIVTQVEFTEFIVEELSDFGDSDDERPGVVRPCAIEYAESDRSRSTSRTRPEIDQRMMFNLGNLNCSDSDETDLEEHEYQEFLIKRRLAARHKRMTSGSIGKRTISESIGSDTDREDIRSFLNSEEAGSSARRLRRRVGDRRSLQFSDPPPPRIEELDEPGSSEDEILAGESLARELPYYEYVSMEVDSPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GR03</accession>
    <name>Q2GR03_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dehydrogenase FUB6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Fusaric acid biosynthesis protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_09601</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227528.1">
        <property type="nucleotide sequence ID" value="XM_001227527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GR03"/>
    <dbReference type="FunCoup" id="Q2GR03">
        <property type="interactions" value="332"/>
    </dbReference>
    <dbReference type="GeneID" id="4396161"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09601"/>
    <dbReference type="eggNOG" id="KOG1196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_29_2_1"/>
    <dbReference type="InParanoid" id="Q2GR03"/>
    <dbReference type="OMA" id="EEKCRYA"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF42">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, ZINC-CONTAINING (AFU_ORTHOLOGUE AFUA_7G04530)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="94"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00069006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00083301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ83197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="361" mass="38891" checksum="ADE0A427B90BCE9E" modified="2006-03-21" version="1">MARQSQQLELAERPTGPIVPGKTFRQRTVAAPTEADLQDGQLLLECLYVSYDPAMRGWLDDKRSYIPPVQIGEVMRAATISRVLASRSAKAKAGDIVTAPLGIREVGILPESQVEPASALVAGAKVTDLLGVFGLTGLTAYFGMTKIGEPKAGDTVVVSAAAGATGSVAAQIAKIAGARVIGTAGSDEKCRWLKEELGLDVALNYKDPEFHRKFKEATPKFIDVFFDNVGGEQLEMALGRANAFSRFVMCGGISQYNSESKSGPTKNFFNIIGQRIKMQGFIVFDYAEEYAAARTQIGQWLGEGKLKRKETILKGGVGASEEALDYLFQGRNIGKLMVEVKNPRGGRGTAVTCMLDQNRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GR39</accession>
    <name>Q2GR39_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_09565</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227492.1">
        <property type="nucleotide sequence ID" value="XM_001227491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GR39"/>
    <dbReference type="GeneID" id="4395087"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09565"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_23_2_1"/>
    <dbReference type="InParanoid" id="Q2GR39"/>
    <dbReference type="OrthoDB" id="5244787at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01345">
        <property type="entry name" value="CERVTRCPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1180"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="15"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1182"/>
            <end position="1191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ85551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1231" mass="138483" checksum="A4382113D3ADFC33" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GR59</accession>
    <name>Q2GR59_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1264 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OBAP family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227472.1">
        <property type="nucleotide sequence ID" value="XM_001227471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GR59"/>
    <dbReference type="GeneID" id="4395187"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09545"/>
    <dbReference type="eggNOG" id="ENOG502QR3B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071931_2_1_1"/>
    <dbReference type="InParanoid" id="Q2GR59"/>
    <dbReference type="OMA" id="CTWQADR"/>
    <dbReference type="OrthoDB" id="1901244at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010686">
        <property type="entry name" value="OBAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360:SF0">
        <property type="entry name" value="OIL BODY-ASSOCIATED PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06884">
        <property type="entry name" value="DUF1264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="27330" checksum="62341D881EF3AC2E" modified="2006-03-21" version="1">MESTDFSPLQNICAHLNAFHVYASDPTRVVEANHYCGHLTEDVRQCLLYDSPSPGARLIGIEYMIKPHLYETLDREERRLWHSHVFEVKSGMLVMPQPSALVPQALWDKAETAEMEQVVELYGKVYHLWQVDRGDKLPLGEPQLMTSLTKADQLPGLEKAMDERDKRFPGCRWREKRAIRKDIEEPPIHPDYTWKKMFVELCLGVNFGFCDKMTIVWPLVNASPRLFRCIKWMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRY9</accession>
    <name>Q2GRY9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PBP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_09265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227192.1">
        <property type="nucleotide sequence ID" value="XM_001227191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRY9"/>
    <dbReference type="STRING" id="306901.Q2GRY9"/>
    <dbReference type="GeneID" id="4395647"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09265"/>
    <dbReference type="eggNOG" id="ENOG502RB9A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058099_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRY9"/>
    <dbReference type="OMA" id="EVMYNDF"/>
    <dbReference type="OrthoDB" id="10260248at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052738">
        <property type="entry name" value="ABC-Tungstate_binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37945">
        <property type="entry name" value="EXTRACELLULAR TUNGSTATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37945:SF1">
        <property type="entry name" value="EXTRACELLULAR TUNGSTATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005694028" description="PBP domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="PBP" evidence="2">
        <location>
            <begin position="50"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ85251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="297" mass="31937" checksum="A3EF9C220ABE867C" modified="2006-03-21" version="1">MVSLRFLAVTTLPLLCAALNPAAVYDGGYGNDSSILLGIGNGGAGQSGLIKALADAFIEQKVSNGSEPFRVAWYQSDTTYSINYLKDALIDVAITYSPAAERIAIEQGIALDPAYYAFRDHFLIVGPPSNPANVSGTSDIYTLFSDLHEAAEAKNTTPPVRFLSRYDKSATNIKESDLWISIGQVPWSTAYSTWYHQYITFPLEALSAAILLDEYTLTDRGTFLSLPANLTSETTVFKAATDAADDPLLNPAHLLVGARAPNPETAAEFARWLVGGEGQKVVGGFEKNGEQLYSPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GS84</accession>
    <name>Q2GS84_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_09170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227097.1">
        <property type="nucleotide sequence ID" value="XM_001227096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GS84"/>
    <dbReference type="STRING" id="306901.Q2GS84"/>
    <dbReference type="GeneID" id="4395247"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09170"/>
    <dbReference type="eggNOG" id="ENOG502S3J6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054813_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GS84"/>
    <dbReference type="OMA" id="HNKGAQK"/>
    <dbReference type="OrthoDB" id="333551at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025066">
        <property type="entry name" value="CCDC174-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13300">
        <property type="entry name" value="DUF4078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ85156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="347" mass="38911" checksum="168CCA37A1A00A29" modified="2006-03-21" version="1">MPQDPHLYGQPPPKKQKKEIALSGSLAFSSQLSSFLAEPSAKSSTSSSAGPTTGRTRPSKLKKDSLSDTKVKRKDSKANTQTKDNNKLSLKSPLGTEDSKAEREFARRKMESKARLYAAMQRGDYIGREVGLVDFDRKWAESQSKKNPTDAAPSSDSDSDSEPDDDEQANNTDTTLHEYTDEFGRVRQLTRAQILRLQRGAASATELENMSARPKAPSTLIYGDAVQAEAFAAHDGGAAMEALARKRDRSPTPPEATHYQADWEIRTKGVGFYKFSKEEGRREEEMKALEAERARTEGLRKEREEKARRRKEEIEERRREILERRTKKMADSFLEGLEKDLVGHDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSC4</accession>
    <name>Q2GSC4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_09130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227057.1">
        <property type="nucleotide sequence ID" value="XM_001227056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSC4"/>
    <dbReference type="STRING" id="306901.Q2GSC4"/>
    <dbReference type="GeneID" id="4395093"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09130"/>
    <dbReference type="eggNOG" id="ENOG502SJJF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024934_8_0_1"/>
    <dbReference type="InParanoid" id="Q2GSC4"/>
    <dbReference type="OMA" id="HWRESHG"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022698">
        <property type="entry name" value="OrsD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF3">
        <property type="entry name" value="ORSELLINIC ACID_F9775 BIOSYNTHESIS CLUSTER PROTEIN D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12013">
        <property type="entry name" value="OrsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ85116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="515" mass="55986" checksum="2A725BF4D29D6A36" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-25" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSI6</accession>
    <name>GPI18_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>GPI mannosyltransferase 2</fullName>
            <ecNumber>2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>GPI mannosyltransferase II</fullName>
            <shortName>GPI-MT-II</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Glycosylphosphatidylinositol-anchor biosynthesis protein 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">GPI18</name>
        <name type="ORF">CHGG_09068</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly.</text>
    </comment>
    <comment type="pathway">
        <text>Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGV family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226995.1">
        <property type="nucleotide sequence ID" value="XM_001226994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSI6"/>
    <dbReference type="FunCoup" id="Q2GSI6">
        <property type="interactions" value="255"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GSI6"/>
    <dbReference type="GeneID" id="4395328"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09068"/>
    <dbReference type="eggNOG" id="KOG2647">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029048_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSI6"/>
    <dbReference type="OMA" id="GALFIWC"/>
    <dbReference type="OrthoDB" id="10252502at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000246244" description="GPI mannosyltransferase 2">
        <location>
            <begin position="1"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="471" mass="50417" checksum="5FE05A32DDC5DEE0" modified="2006-03-21" version="1">MAPKHQTPHTHAQIHTHPYRTLLTSFAAWKLFLFAIVLGSTLVGDAYDTSGGLLLQGPANGDAATRPAGLGTTLIARLTSWDAIYYVSAARRDYVFEQEWAFGAGLPFVVRTLLQGLEYVGIIDAPGAEGGRALVAEALAGILVANTAHLLSALVLYRLGQVVWRDQTLSLVAALLHVISPAGLFLSAPYSESSFALLSFSGYLLFALGCRAEGSSNSNNSPTRRDLYTISAGVLFGAATVFRSNGLLNGAPFALEVLRHLPAFVRRPTAIDTLRRLAALGVGGAAVAAGSLGPQAAAYLRYCIPSSSSGASDGEENLLLPRPWCQGYLPSIFTFVQQHYWNVGFLRYWTLPNLPLFLLATPMLVILVKSGVDSLRGRHLPGDAKAVDGESGRLLALIRSTAAAQVLLAVLAATTYHVQIITRISSGYPVWHWWLAGRLVQGDKTGSRIVMFMVIYASIQGALFASFLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSJ1</accession>
    <name>Q2GSJ1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_09063</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226990.1">
        <property type="nucleotide sequence ID" value="XM_001226989.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GSJ1"/>
    <dbReference type="GeneID" id="4395702"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09063"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_229543_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSJ1"/>
    <dbReference type="OrthoDB" id="408320at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005990">
        <property type="term" value="P:lactose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000018">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050347">
        <property type="entry name" value="Bact_Beta-galactosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323:SF2">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta galactosidase small chain/" evidence="10">
        <location>
            <begin position="772"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1897"/>
            <end position="1929"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1930"/>
            <end position="1962"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1963"/>
            <end position="1995"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1996"/>
            <end position="2028"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="2029"/>
            <end position="2061"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="2062"/>
            <end position="2094"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="2095"/>
            <end position="2127"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="2128"/>
            <end position="2160"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="2161"/>
            <end position="2193"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="2194"/>
            <end position="2226"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="2227"/>
            <end position="2259"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="2260"/>
            <end position="2292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2296"/>
            <end position="2367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2296"/>
            <end position="2305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2345"/>
            <end position="2367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ85049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="2367" mass="263856" checksum="3670617A15EB466E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSM5</accession>
    <name>Q2GSM5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxin 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226956.1">
        <property type="nucleotide sequence ID" value="XM_001226955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSM5"/>
    <dbReference type="STRING" id="306901.Q2GSM5"/>
    <dbReference type="GeneID" id="4394872"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09029"/>
    <dbReference type="eggNOG" id="ENOG502S3XI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039527_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSM5"/>
    <dbReference type="OMA" id="DHHWDEM"/>
    <dbReference type="OrthoDB" id="5407351at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.230">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="38973" checksum="9C77E2A937081865" modified="2006-03-21" version="1">MADSMCGPSNGAKNLLSHVDRDRTHHQDRFVNAPQAGPGNAFRSQAPFANGAETAFGGFQQGGAPMDSAFGPGLDMNTIAGARAYGHPAPAAPTAMTNIGPGVPAARLASPATGGTSHQEWVNQFSGMQIGGARAGPSTAIAPQMQSTPMAAMNPAMNMQQAAFGMPMYNGLSAGVYGLQGMNPIAQQQPQIAVAQDSDLDVEAFNRAFGEYDDVNFKTELADWTEKQQVANTEFAEAQDKWMAQHGPRVDPTTGVTVPSPDEMEAIDANLEKLAQEQDKRRSDDDLVHAAIDIVNSVSDNTSEKFKNSRFFELMRRIGNREVVVEGDGFVNAATGEAVNTSHDDEQHDSGLGSDAATPQKAPEVQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSP0</accession>
    <name>Q2GSP0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226941.1">
        <property type="nucleotide sequence ID" value="XM_001226940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSP0"/>
    <dbReference type="GeneID" id="4395000"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09014"/>
    <dbReference type="HOGENOM" id="CLU_2558110_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSP0"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="82" mass="9183" checksum="0AC9FDAD87B6A0B4" modified="2006-03-21" version="1">MLPTPPHHHQLLHHLLPPPIRRPRLHHHLRRPRGWRAPAARLRRSLSVLAGRAYHADGGDEGGSEEDEEDGAEDADCGDGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTN2</accession>
    <name>Q2GTN2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226599.1">
        <property type="nucleotide sequence ID" value="XM_001226598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTN2"/>
    <dbReference type="STRING" id="306901.Q2GTN2"/>
    <dbReference type="GeneID" id="4395463"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08672"/>
    <dbReference type="eggNOG" id="KOG2804">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034585_5_1_1"/>
    <dbReference type="InParanoid" id="Q2GTN2"/>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="370" mass="39101" checksum="1C95A66374246FC1" modified="2006-03-21" version="1">MSSSNSAAQGAGKRKRNNTSATLDMDQNQTIQNESRDASGEEGDTTAPESSRTAANAHRKTDSSSSAHPNKRQRASSDQLPPSSTAASAIGHHTQARDPGEPSDTTEASVDIAERVTRKGSRKLTSSKGGDASANGSSMTSSKTTAAMAPPPIGKLTHPGGIHDKPASRGPGPIVRDYEKYIARQLKRGTSRQELNISWLKKNELELKRHVQDLRDNIRTNWTTTGQELSRELRQYWPTSRPQSPSPARFASGNGNGSGSASINGGDLPPSSPLGPAGGAAGGSAFPFPRSPPTGVATAGERATSTSNDFVTGYTLGLIGGVRSWMTKSRRGEREGESRPVSDDDSEESEDKHGSDGRRSMQLPATSQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTX8</accession>
    <name>Q2GTX8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226503.1">
        <property type="nucleotide sequence ID" value="XM_001226502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTX8"/>
    <dbReference type="GeneID" id="4395467"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08576"/>
    <dbReference type="eggNOG" id="ENOG502RHTD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_407677_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTX8"/>
    <dbReference type="OrthoDB" id="4590933at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="674" mass="74727" checksum="7C2133D3A69752F6" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU16</accession>
    <name>Q2GU16_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-dependent DNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226465.1">
        <property type="nucleotide sequence ID" value="XM_001226464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GU16"/>
    <dbReference type="GeneID" id="4395440"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08538"/>
    <dbReference type="HOGENOM" id="CLU_430199_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GU16"/>
    <dbReference type="OrthoDB" id="3934771at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="636" mass="69561" checksum="89D38EA24155BA8F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU99</accession>
    <name>Q2GU99_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_08455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226382.1">
        <property type="nucleotide sequence ID" value="XM_001226381.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4395377"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08455"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_23_2_1"/>
    <dbReference type="InParanoid" id="Q2GU99"/>
    <dbReference type="OrthoDB" id="4368687at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
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        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="387"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="507"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ84441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1393" mass="155015" checksum="B5D860DB3869A256" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUL9</accession>
    <name>Q2GUL9_CHAGB</name>
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        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_08335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001226261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUL9"/>
    <dbReference type="STRING" id="306901.Q2GUL9"/>
    <dbReference type="GeneID" id="4394782"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08335"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_23_5_1"/>
    <dbReference type="InParanoid" id="Q2GUL9"/>
    <dbReference type="OrthoDB" id="5244787at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="4">
        <location>
            <begin position="144"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ84321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="872" mass="96721" checksum="A4C3148D66630A50" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUR7</accession>
    <name>Q2GUR7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_08287</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ87034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225943.1">
        <property type="nucleotide sequence ID" value="XM_001225942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUR7"/>
    <dbReference type="STRING" id="306901.Q2GUR7"/>
    <dbReference type="GeneID" id="4394501"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08287"/>
    <dbReference type="eggNOG" id="KOG3437">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039415_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUR7"/>
    <dbReference type="OMA" id="SIVHIRI"/>
    <dbReference type="OrthoDB" id="24948at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08366">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016901">
        <property type="entry name" value="APC10/Doc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DOC" evidence="7">
        <location>
            <begin position="63"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ87034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="291" mass="32346" checksum="4D658CDAE57383BE" modified="2006-03-21" version="1">MPRSATTDHDFPNDDDTHFAGGAYEHGEISDEELMEGIGEGDDEMLGDAVTEDPGDEMSDGNDEDLHSGDEMDDDPFSPTELGLKEINNLAHFGVSSHRPGNGVAELLSDDLDKYWQSDGQQPHLLTIHFLRRVEIRAIRFYVDYNQDESYTPTHIVFYAGTGHHDLIQFAETPLTNPAGWQDVPIADSGGGADGHSLCCWMVQMHIKENHQNGKDTHIRGIKVYALDDHSLGSTAREPTRGSRVGVEDDHARGRTTQGLDDQSLQELLDAFERHPITPSNFDTVREPTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV79</accession>
    <name>Q2GV79_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like modifier HUB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_08125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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        </lineage>
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            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <property type="nucleotide sequence ID" value="XM_001225780.1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08125"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077999_0_0_1"/>
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    <dbReference type="OMA" id="QSSEPMI"/>
    <dbReference type="OrthoDB" id="3881at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hub1/Ubl5"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
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        <location>
            <begin position="161"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ86872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="236" mass="27423" checksum="0A8845C1AB990686" modified="2006-03-21" version="1">MPDSPRRRSRSRSPPRRPKAAGGFKWKDKRSNDADDRRDDRGLQRGYRDRSPRRDRERDRESGRDRDRDRGGNRDRDRSPRRDRSRDRDRERDRDRDGDRAHRRSDRDRERDRSPRNSNRLTDRDRDRDRDAQTRPKKSKPPAPPPAAAPAPAAAPGEQMILVTVNDRLGTKAQIPAFPSDTVGQFKIMVAMKVGREPHEIMLKRQGERPFKDMITLGDYGVSNGVQLDLEVDTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="61" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="3 4">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="STRING" id="306901.Q2GVF3"/>
    <dbReference type="GeneID" id="4393943"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08051"/>
    <dbReference type="eggNOG" id="KOG2058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005609_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GVF3"/>
    <dbReference type="OMA" id="WQDYLRI"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
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        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
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    </dbReference>
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        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RabGAP-TBC"/>
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    </dbReference>
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        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TBC_RABGAP"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="752"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1082"/>
        </location>
    </feature>
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        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
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        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
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        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
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            <end position="112"/>
        </location>
    </feature>
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        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
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        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
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        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ86798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1082" mass="116371" checksum="B7E3A106E531BEAB" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVI7</accession>
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        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">CHGG_08017</name>
    </gene>
    <organism evidence="6 7">
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR48 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EAQ86764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="4393954"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08017"/>
    <dbReference type="eggNOG" id="KOG0308">
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    <dbReference type="HOGENOM" id="CLU_002197_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GVI7"/>
    <dbReference type="OMA" id="PMWLGDV"/>
    <dbReference type="OrthoDB" id="2421129at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
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    </dbReference>
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        <property type="entry name" value="WD40_rpt"/>
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    <dbReference type="PANTHER" id="PTHR19862">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF3337"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
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    </dbReference>
    <dbReference type="SMART" id="SM00320">
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        <property type="match status" value="5"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="20"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="102"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="191"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="528"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="679"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="614"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="639"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ86764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="939" mass="102256" checksum="FEEB9DBE138705A6" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVP8</accession>
    <name>Q2GVP8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Shugoshin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_07956</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shugoshin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225612.1">
        <property type="nucleotide sequence ID" value="XM_001225611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVP8"/>
    <dbReference type="STRING" id="306901.Q2GVP8"/>
    <dbReference type="GeneID" id="4394243"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07956"/>
    <dbReference type="eggNOG" id="ENOG502SFX7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013723_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GVP8"/>
    <dbReference type="OMA" id="ENECACM"/>
    <dbReference type="OrthoDB" id="5394106at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011515">
        <property type="entry name" value="Shugoshin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011516">
        <property type="entry name" value="Shugoshin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07557">
        <property type="entry name" value="Shugoshin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07558">
        <property type="entry name" value="Shugoshin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shugoshin N-terminal coiled-coil" evidence="12">
        <location>
            <begin position="18"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Shugoshin C-terminal" evidence="11">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="107"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="180"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="456"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="624"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ86703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="753" mass="81543" checksum="BE052C57AFF25D26" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GW57</accession>
    <name>Q2GW57_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Wings apart-like protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_07797</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WAPL family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225453.1">
        <property type="nucleotide sequence ID" value="XM_001225452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GW57"/>
    <dbReference type="STRING" id="306901.Q2GW57"/>
    <dbReference type="GeneID" id="4394306"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07797"/>
    <dbReference type="eggNOG" id="ENOG502RZXD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011973_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GW57"/>
    <dbReference type="OMA" id="NNKPKAC"/>
    <dbReference type="OrthoDB" id="78088at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039874">
        <property type="entry name" value="WAPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022771">
        <property type="entry name" value="WAPL_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100:SF13">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07814">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wings apart-like protein C-terminal" evidence="3">
        <location>
            <begin position="399"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ86544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="865" mass="94086" checksum="30879345648A716C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GW98</accession>
    <name>Q2GW98_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CHGG_07756</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225412.1">
        <property type="nucleotide sequence ID" value="XM_001225411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GW98"/>
    <dbReference type="STRING" id="306901.Q2GW98"/>
    <dbReference type="GeneID" id="4393720"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07756"/>
    <dbReference type="eggNOG" id="ENOG502RAK7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031730_0_2_1"/>
    <dbReference type="InParanoid" id="Q2GW98"/>
    <dbReference type="OMA" id="TSGLKWF"/>
    <dbReference type="OrthoDB" id="2525337at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF13">
        <property type="entry name" value="ENDOGLUCANASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012904007" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="17">
        <location>
            <begin position="16"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="18">
        <location>
            <begin position="270"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAQ86503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="306" mass="31620" checksum="3C06720EAEC628EC" modified="2006-03-21" version="1">MKAFSLVTLATAVSGHAIFQRLSVNGQDQGQLKGIRAPYSNYPIQNVNDANIACNANIQIKDNNIIKIPAGARVGAWWQHEIGGPSGPNDQDNPIAASHKGPITVYLAKVSNAASASASGQQWFKIAERGVNNGVWAVDEMISNNGWHYFDVPSCVAPGQYLMRVELLALHSASTAGGAQFYMECAQVEITGSGTNSGSNFVSFPGAYPANHPGIVVSIYDSTGKPTMNGRTYQIPGPAPISCSGGNNGGGSNPTTTAGGSQPTGGNGGGSVPLYGQCGGNGYTGPTTCAQGTCKASNEWYSQCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWL2</accession>
    <name>Q2GWL2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_07642</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225298.1">
        <property type="nucleotide sequence ID" value="XM_001225297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWL2"/>
    <dbReference type="STRING" id="306901.Q2GWL2"/>
    <dbReference type="GeneID" id="4393763"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07642"/>
    <dbReference type="eggNOG" id="ENOG502SH49">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011017_3_1_1"/>
    <dbReference type="InParanoid" id="Q2GWL2"/>
    <dbReference type="OMA" id="CPIIHRR"/>
    <dbReference type="OrthoDB" id="3037908at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF3">
        <property type="entry name" value="C6 FINGER DOMAIN TRANSCRIPTION FACTOR DBAA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="117"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ86389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="616" mass="68217" checksum="87C72AF846C87222" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWY9</accession>
    <name>Q2GWY9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Membrane insertase YidC/Oxa/ALB C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_07515</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225171.1">
        <property type="nucleotide sequence ID" value="XM_001225170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWY9"/>
    <dbReference type="FunCoup" id="Q2GWY9">
        <property type="interactions" value="518"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GWY9"/>
    <dbReference type="GeneID" id="4394326"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07515"/>
    <dbReference type="eggNOG" id="KOG1239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029282_5_1_1"/>
    <dbReference type="InParanoid" id="Q2GWY9"/>
    <dbReference type="OrthoDB" id="2148490at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013262">
        <property type="entry name" value="OMP_MIM1/TOM13_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF66">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08219">
        <property type="entry name" value="TOM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="453"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="12">
        <location>
            <begin position="297"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="554"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ86262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="600" mass="65805" checksum="7B002EFD7AA4134B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWZ7</accession>
    <name>Q2GWZ7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_07507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225163.1">
        <property type="nucleotide sequence ID" value="XM_001225162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWZ7"/>
    <dbReference type="GeneID" id="4394397"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07507"/>
    <dbReference type="eggNOG" id="ENOG502S0NK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039214_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GWZ7"/>
    <dbReference type="OMA" id="PIIIHAG"/>
    <dbReference type="OrthoDB" id="2149705at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ86254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="487" mass="53374" checksum="3D12F45A17F5A220" modified="2006-03-21" version="1">MNQLLKTKSHLGRFGVRAYTSRRPRPCILNFSTTNKLSNPIDRATAARDFVALLTPIANAEQEPVLPKPSGGDASSVPDRRKVLSAIESLLHTLNPEQPLYAAFHDGLVHDPLGGGSYAFRDDLIKPLLEGLMHDEALNLDAYAEARLADNIPSRPIVIHAGAQPNNSPHCGTLIVFCYAFAVARAMRDRMQAMAAHSRAVFQPPPVSVNITFVDTAPVKGEGLEIDGIHYQKSYRDTPSASATWTGDYHEVLNLLSRWSNIPVTTTVQSDFFSNPFVPQLLDYFITNHRTLGRQLSPKYGTLALRAACPIPGCNLAEKHGRLNRYTKSTTTPDTPAAIIFHCPHHGPHTIPITRNPPALSRLEANAPTRNLLRSMSHLLDTHTHHVRVTGADYAGGVPGGDALPAAGGVERSDGGERGRVLGTAGLGSYRVLKRGVVGGDRVAGDEEGLRRIWEEVGRWVADPRKLFRCYSVEYLRRVIVEGRAWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXI5</accession>
    <name>Q2GXI5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_07319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224975.1">
        <property type="nucleotide sequence ID" value="XM_001224974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXI5"/>
    <dbReference type="GeneID" id="4394073"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07319"/>
    <dbReference type="HOGENOM" id="CLU_1970279_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GXI5"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ86066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="127" mass="14406" checksum="209DDE6830E4D50A" modified="2006-03-21" version="1">MSAPRESRRLRDQTTVAWAVSQCDACSQRSRVADFRLHRGARKAAGGIWSGCGHLDRCCLGPVQDLRYHRRSAVEATQQRVLCLFMQHVEEWMCCGRALQRLDQCDRHAASCRRCSEGFLGNPAQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYG1</accession>
    <name>Q2GYG1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ecm33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_06993</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224649.1">
        <property type="nucleotide sequence ID" value="XM_001224648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYG1"/>
    <dbReference type="FunCoup" id="Q2GYG1">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GYG1"/>
    <dbReference type="GeneID" id="4394413"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06993"/>
    <dbReference type="eggNOG" id="ENOG502QUZC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035846_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GYG1"/>
    <dbReference type="OMA" id="WANNITF"/>
    <dbReference type="OrthoDB" id="536881at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051648">
        <property type="entry name" value="CWI-Assembly_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018:SF3">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12454">
        <property type="entry name" value="Ecm33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209117" description="Protein ecm33" evidence="7">
        <location>
            <begin position="19"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="353"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ85740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="42256" checksum="FCBA22B370D9E486" modified="2006-03-21" version="1">MFVKQLLPALVAIGSAAAQSATCTVSTTTINGQAEATKLAGCGTVKGTVVLGSQGGATVELSGPKEITGNLIVENNGMLETFSSPSLQKIGGTFRLQNVTFLTSLQFPKLTEAQSIEWGSVTRLDSVTLGPLDKADNVRVSDTFLDNLDAFSLTTVKKLTLDNNRRLSKYTSQLTSLSDRLVIQANGLELEVDLSSLKWINDMEIANVTKFSVPALQVVNGSALFDSNRFPTFSAPNLTHTEKGDISFVGNGFLKNMTFPKLTDIAGGLLIANNTGLDEVTFFPKLRKVSGAVKLRGNFTTVDFPSLDNVKGAFDVSSTANIRKSCDKLGEKAPRSQGGDGSIEGVFTCTADNENANEDTDGSTSNSGNVDGTDGSDENGASGPVFNAALFGLVAVAGLASAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYU4</accession>
    <name>Q2GYU4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Yippee domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_06860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the yippee family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224516.1">
        <property type="nucleotide sequence ID" value="XM_001224515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYU4"/>
    <dbReference type="STRING" id="306901.Q2GYU4"/>
    <dbReference type="GeneID" id="4394085"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06860"/>
    <dbReference type="eggNOG" id="KOG3399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043857_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYU4"/>
    <dbReference type="OMA" id="YLRCARC"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="146"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ85607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="339" mass="36820" checksum="B7E42E9404B52A84" modified="2006-03-21" version="1">MSFLQPSVSAPPLPSRPKFPRYLLPALRIPFTRWRIPEPALQTPGSSDPPSPTGSNTSTSTSNTSAVPSLSTSPTSPTTPSTAGRRLSRTRPDTLRCRSCATDLAFHTQIVSKWFRGRHGRAYLVAPPPPIFPTAIRSRVHAPANTITHTTSIRRHVPFTPVLVPQPPPQTAAAKVALAGDLIDELVSGANLLNVTLGPEEDRPLMTGRHVVADARCAVCGATVGWKYVSTGQPSQAYKVGCFILETRRVVSCRGWEDGDEWVHGRAGLSLDGRPLGVDGSEEEVIPVGWAEDWKGEGEKEQDAVVFDSDDEDECEDMFEGVWDARVVACRRRRKAGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZ92</accession>
    <name>Q2GZ92_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224368.1">
        <property type="nucleotide sequence ID" value="XM_001224367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZ92"/>
    <dbReference type="GeneID" id="4392933"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05154"/>
    <dbReference type="HOGENOM" id="CLU_2061228_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZ92"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="119" mass="12497" checksum="A535D66155E5BAB9" modified="2006-03-21" version="1">MAFHHASITKRKSVTVPGAHTNCREVCSRVIVSAFLKRLLKDCAAGEPVQEDASSSPTTRWAQIPLCTSLQLIVCMSTSQSPSEQIPDDSEGSGVGSTGVSALANLDSRGGRLSWPIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZS0</accession>
    <name>Q2GZS0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_04976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224190.1">
        <property type="nucleotide sequence ID" value="XM_001224189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZS0"/>
    <dbReference type="GeneID" id="4392676"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04976"/>
    <dbReference type="HOGENOM" id="CLU_2812119_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZS0"/>
    <dbReference type="OrthoDB" id="9999611at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ88357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="67" mass="7468" checksum="2B0EF11F3CC4F45E" modified="2006-03-21" version="1">MSSPPNNPQDPSRPDQPGLWTAHAEYIKGAAERSTIGNKKSAVGCTHEIRRFGRESETTDKVMEDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H042</accession>
    <name>Q2H042_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_04854</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224068.1">
        <property type="nucleotide sequence ID" value="XM_001224067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H042"/>
    <dbReference type="FunCoup" id="Q2H042">
        <property type="interactions" value="419"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H042"/>
    <dbReference type="GeneID" id="4392799"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04854"/>
    <dbReference type="eggNOG" id="KOG1489">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011747_2_6_1"/>
    <dbReference type="InParanoid" id="Q2H042"/>
    <dbReference type="OMA" id="PRVGHWE"/>
    <dbReference type="OrthoDB" id="347018at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF31">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="5">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="234"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ88235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="505" mass="54357" checksum="03B8C54FBFE583AF" modified="2006-03-21" version="1">MSTFADKAKLNLYAGNGGHGCISFLREAYLEDGPANGGDGGHGGNIYIQAVHGETSLHKLSRRKIVRAGKGKSGMGGARGGRRGDDVVIAVPVGTVVRELSRDDPEAENRFLANRDKKRVGRDVLPVEEGPDGEPIDDPSRSKWMLYPGMSSSDMKRIQLPPLPNRERLLQQPKAPIQLDLSRPTPRPILLAVGGIGGLGNPHFVTKGTPKPMFATRGEGAVSMEIELELKLLADVGLVGLPNAGKSTLLRSISNSRTRVGNWAFTTLQPNIGTVVLDNNKGRPVLTSYRKVSDASPLRDDPFNLSAEPQPGLERRTRFTIADIPGLIEGAHLDKGLGIAFLRHVERAGVLAFVLDLGAGNAVQALKALWNEVGLYAHMREEEERERKRQAAVDWSATAGTDAEDSTFWPSSMTDDYSTPAANTGGLHIAGKPWFVVATKGDLLDTQENFKELREYLAAIGRGEEPHPSGVEGAWTHDCAAIPVSAIKGQGVDRVVHWAVGLLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H090</accession>
    <name>Q2H090_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_04806</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
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        <property type="nucleotide sequence ID" value="XM_001224019.1"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="C:mitotic spindle pole body"/>
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        <property type="term" value="P:cytoplasmic microtubule organization"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:meiotic cell cycle"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:microtubule nucleation"/>
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        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GCP"/>
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        <property type="entry name" value="GCP_C"/>
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        <property type="entry name" value="GCP_C_sf"/>
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        <property type="entry name" value="GCP_N"/>
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        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
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            <begin position="180"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="520"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="838"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="940"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="71"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="93"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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            <begin position="100"/>
            <end position="124"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="950"/>
            <end position="962"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ88187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="962" mass="108301" checksum="5FEB6B393D6AED47" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0S0</accession>
    <name>IML1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Vacuolar membrane-associated protein IML1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">IML1</name>
        <name type="ORF">CHGG_04626</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IML1 family.</text>
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    <dbReference type="Proteomes" id="UP000001056">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:intracellular signal transduction"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:negative regulation of TORC1 signaling"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
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    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19418">
        <property type="entry name" value="DEPDC5_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
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    <dbReference type="SMART" id="SM00049">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="chain" id="PRO_0000301768" description="Vacuolar membrane-associated protein IML1">
        <location>
            <begin position="1"/>
            <end position="1889"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="2">
        <location>
            <begin position="1331"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="74"/>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="540"/>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="570"/>
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        <location>
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            <end position="1272"/>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1424"/>
            <end position="1484"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1724"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="729"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="747"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="787"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="840"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="865"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1737"/>
            <end position="1789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1801"/>
            <end position="1811"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="1889" mass="211950" checksum="F562424015EA384C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0W9</accession>
    <name>Q2H0W9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223791.1">
        <property type="nucleotide sequence ID" value="XM_001223790.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2H0W9">
        <property type="interactions" value="894"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H0W9"/>
    <dbReference type="GeneID" id="4391776"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04577"/>
    <dbReference type="eggNOG" id="KOG0928">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001204_3_1_1"/>
    <dbReference type="InParanoid" id="Q2H0W9"/>
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    <dbReference type="OrthoDB" id="10258608at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="GBF1-like_TPR"/>
    </dbReference>
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        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
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        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
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        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
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        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR_28"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="665"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1337"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1584"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1598"/>
            <end position="1612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1612" mass="177392" checksum="A8F6FD9940A6B55A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H186</accession>
    <name>Q2H186_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mago nashi protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_04460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001223673.1"/>
    </dbReference>
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    <dbReference type="STRING" id="306901.Q2H186"/>
    <dbReference type="GeneID" id="4391707"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04460"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_109497_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H186"/>
    <dbReference type="OMA" id="IRKEMWI"/>
    <dbReference type="OrthoDB" id="6495301at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein mago nashi homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ87841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="17839" checksum="DBDB0F52D65C2A03" modified="2006-03-21" version="1">MSNLNEPFYIRYYSGHQGRFGHEFLEFDFRVVGDGRSATARYANNSNYRNDSLIRKEMFVSSLVVDEIKRIVKESEILKEDDAKWPTKNKDGRQELEIRVGNDHISFETAKIGSINDVTESADPEGLRVFYYLVQDLKALVFSLIALHFKIKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1B7</accession>
    <name>Q2H1B7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-hydroxyacyl-CoA dehydrogenase NAD binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_04429</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223643.1">
        <property type="nucleotide sequence ID" value="XM_001223642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1B7"/>
    <dbReference type="STRING" id="306901.Q2H1B7"/>
    <dbReference type="GeneID" id="4392556"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04429"/>
    <dbReference type="eggNOG" id="KOG2304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H1B7"/>
    <dbReference type="OMA" id="WASNERP"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF3">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="4">
        <location>
            <begin position="98"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="3">
        <location>
            <begin position="296"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ87810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="45991" checksum="3A0F77351A3DB78A" modified="2006-03-21" version="1">MSGSKQLAVKAFPAVGTATIAGKSQPIYTSVSRTRGLTYLTSRPPSWRVSLNPYCRHLPATQHSPFTTSSRRSTEGSGEPHAPKWRPPTDEGLKQRPVLVIGAGNIGRRVALVWASNERPVTIYDISPTALKSATEYITDNLAAYCTARGTHPGHVRTTSDLRTATTTSGFPARDSAGAITAEEHTKAPWLAIECLPESLPLKTSVLALLERSLPSDCVLASNSSSLTTAEMAAEGPLDYPHRLLNTHYFIPPRNRMVELMSSGATAGQIFPFLASQMRRVGFAPVIVPRDIQSRGFVFNRIWAACKRETLAVLAEGVAEPADVDALFRDFFHAEKGPCERMDEVGLDTVARVEQHNLERKPELASEGPLKWLRENYVRVGKLGEKSGDGLFKGEERDRLRERHYLERYKVVEETSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1D3</accession>
    <name>Q2H1D3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_04413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223627.1">
        <property type="nucleotide sequence ID" value="XM_001223626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1D3"/>
    <dbReference type="GeneID" id="4392863"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04413"/>
    <dbReference type="eggNOG" id="ENOG502SNZF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1677667_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H1D3"/>
    <dbReference type="OrthoDB" id="4499271at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ87794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="157" mass="17593" checksum="0EF2E658135C4FD5" modified="2006-03-21" version="1">MHMVAGYGVGIYVQSETLWFLPPLDPTLANPKSDTLPPYLAFACDRTALPPEAPGFGMGAFNSDETVVLVPRAHILTEALMRIMAVDYGTPMGLWSEQHYCYIERFVEKRGLLHLDLLPRPLANIHKAFRDGPESIGKVHVELLRTLGVPVHPKYYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1S6</accession>
    <name>Q2H1S6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_04270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223484.1">
        <property type="nucleotide sequence ID" value="XM_001223483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1S6"/>
    <dbReference type="GeneID" id="4392999"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04270"/>
    <dbReference type="eggNOG" id="ENOG502RJA8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1441993_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H1S6"/>
    <dbReference type="OMA" id="YCAIDGD"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ87651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="206" mass="22944" checksum="A30B97AA71F67DBB" modified="2006-03-21" version="1">MYCAIDGDVFDLGRYLHSHPGGAQILYAYAGRDATSLKIDDVSLFHQLTPYTGTDATHLLKTEDPPPALLELLKRDNLVCAKLVSSTRRLITPVEFSRRNHFPSKTERQNSFGARDTNWRVWVAVAEKEGSKKQMVYDVTSRRAQVLRGRGQYVGEKLAGSKRRVGALDDAVLETYGEEIEASWGLEVNMDADGQHLNGGFLLSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H215</accession>
    <name>Q2H215_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223395.1">
        <property type="nucleotide sequence ID" value="XM_001223394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H215"/>
    <dbReference type="STRING" id="306901.Q2H215"/>
    <dbReference type="GeneID" id="4392839"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04181"/>
    <dbReference type="eggNOG" id="ENOG502SACR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_321077_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H215"/>
    <dbReference type="OrthoDB" id="3545073at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022190">
        <property type="entry name" value="DUF3716"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12511">
        <property type="entry name" value="DUF3716"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="863"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="890"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1057" mass="114619" checksum="92740A8059548D80" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H293</accession>
    <name>Q2H293_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_04103</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223317.1">
        <property type="nucleotide sequence ID" value="XM_001223316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H293"/>
    <dbReference type="GeneID" id="4392068"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04103"/>
    <dbReference type="eggNOG" id="ENOG502RIXI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_963124_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H293"/>
    <dbReference type="OrthoDB" id="5242494at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208852" description="LysM domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="27"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ87484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="289" mass="30766" checksum="A0F1F52E75439903" modified="2006-03-21" version="1">MVAIFLTKSFLLLALGFSQQVIAECTQSITAKQGDTCASISSQVGITVTDFLRSNPSVTSCSLVAGQSYCVKGTADSGTPPQTSTPAGLVIRRLLFGPRLLRQHQRLLRRRLSGRVWKLRFRLRRAVPVSRRLPSPSRSPASQTSVITFHRHPKRAPPATVTQTQTSTVTQPRATTTTTVTRTLGGGGTVTTTVSVPATITSVVRLTTVVTSVRTSVSVSTSVSTRTVTVTSLVVDTITSIETSTRLVTSGVCATKTTTGKPTTTAPPEGRPTLPGTPMHWYILGYGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H297</accession>
    <name>Q2H297_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_04099</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223313.1">
        <property type="nucleotide sequence ID" value="XM_001223312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H297"/>
    <dbReference type="STRING" id="306901.Q2H297"/>
    <dbReference type="GeneID" id="4392054"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04099"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_274848_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H297"/>
    <dbReference type="OMA" id="YYALEHI"/>
    <dbReference type="OrthoDB" id="10029326at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="583"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="658"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="702"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="747"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="780"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="315"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ87480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1164" mass="130349" checksum="21A9A87967C01A94" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2B9</accession>
    <name>Q2H2B9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein HRI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_04077</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HRI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223291.1">
        <property type="nucleotide sequence ID" value="XM_001223290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2B9"/>
    <dbReference type="GeneID" id="4392619"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04077"/>
    <dbReference type="eggNOG" id="ENOG502S8GG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060351_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H2B9"/>
    <dbReference type="OMA" id="TVERWEW"/>
    <dbReference type="OrthoDB" id="4045395at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd11693">
        <property type="entry name" value="HRI1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11692">
        <property type="entry name" value="HRI1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.320">
        <property type="entry name" value="Protein HRI1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031818">
        <property type="entry name" value="Hri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038744">
        <property type="entry name" value="Hri1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043047">
        <property type="entry name" value="Hri1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16815">
        <property type="entry name" value="HRI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ87458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="300" mass="32636" checksum="517368C6CBCDE9A0" modified="2006-03-21" version="1">MSCSPHFKASRYDVMPPQTCKPSETMPAVKPATESGSAITGTRGRNRRESIRWLPDEASEPTSTIVLTTPSRRFVDLRILKSDSSASASAVLPDHVTLPLSRLDWAIAGTSSSSVIPSNGEPGKEIRHGQWAHWIDSRAADCDGVVDEGDMFDDPSDASLTLETGRMLNPATGVETDYEEVWRSDPIETVPAPGGGDGQVTCLALQMESVTGSGSEGPGKRVKRGLVVRLGQYCQAFARDGDNITVERLKWDTAQQWWVTQVRIGDQELPIEIATHLAHETTLDDEVRVGGAIWKVVERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2H8</accession>
    <name>Q2H2H8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitin-binding type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_04018</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223232.1">
        <property type="nucleotide sequence ID" value="XM_001223231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2H8"/>
    <dbReference type="GeneID" id="4391536"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04018"/>
    <dbReference type="eggNOG" id="ENOG502RJBP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1175278_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2H8"/>
    <dbReference type="OrthoDB" id="1193027at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208840" description="Chitin-binding type-1 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="4">
        <location>
            <begin position="36"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ87399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="236" mass="24255" checksum="E53982CC0CDC4DF0" modified="2006-03-21" version="1">MLLHLTALLLLPLGALTAAVHPPQSQAVTPRAVSPDNTCGADHSGYTCPGALPCCSQYGFCGATDAFCLTTAKCQTRFSNSSAACHAPVPGTSVSIDGTCGTEGAGKEGYRCPGNATVTSCCSAATPREGASQSSWISQNFPTDTSTQGHLPKASQAAPMRVLSVLSLPLVTELTDHCRAVVILIGDLYLVLSVLSLGLATELTDHLDHLPGSLIGPSNDCLGASRDPRSLLLAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2X5</accession>
    <name>Q2H2X5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_03871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223085.1">
        <property type="nucleotide sequence ID" value="XM_001223084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2X5"/>
    <dbReference type="GeneID" id="4392010"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03871"/>
    <dbReference type="HOGENOM" id="CLU_2426815_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2X5"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ87252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="91" mass="9977" checksum="1C8DAE735D8F080D" modified="2006-03-21" version="1">MTHHAGASDEHALGEIKIRRTPVTINLYDSRLAHTATPGIKVEDGKVKITSRFSIPESGEELSSLPGLDVQPSGQETYNYMVPYRVVGEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H390</accession>
    <name>Q2H390_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_03756</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222970.1">
        <property type="nucleotide sequence ID" value="XM_001222969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H390"/>
    <dbReference type="GeneID" id="4392484"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03756"/>
    <dbReference type="eggNOG" id="ENOG502S2BC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044876_3_3_1"/>
    <dbReference type="InParanoid" id="Q2H390"/>
    <dbReference type="OMA" id="WMSISCG"/>
    <dbReference type="OrthoDB" id="9984533at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="9"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ87137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="307" mass="33684" checksum="4180DED33266F7D4" modified="2006-03-21" version="1">MSTRRTPFKNVLLIGAGGSIGRYILAALLAEPTLTTTVLTRASSQTTLPTGVRTITIPDDYPTASLTTAFHNQDVVISCLTTLSTSDQFRFVDAALAAGVRRYVPSEYGLNNARADAQALNVVFRDKGAVQAYLREREGRMEWMAVSCGMWIGWSVRNDFLGMRVRERPGRVEVWDGGEGRFSVTTEENTALAVVRGLVEIPEETKNRSVLVEELVTTQAELFGEIERQRGEKLVVEEVDSVERIAELQAAYANGDKTATYGLIEAGFVTGRYGGDLAKEGEIFTEKLRLQRHSLQEVVASALASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3C8</accession>
    <name>Q2H3C8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_03718</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222932.1">
        <property type="nucleotide sequence ID" value="XM_001222931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3C8"/>
    <dbReference type="FunCoup" id="Q2H3C8">
        <property type="interactions" value="679"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H3C8"/>
    <dbReference type="GeneID" id="4391770"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03718"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023312_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3C8"/>
    <dbReference type="OMA" id="FAWQGMQ"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14518">
        <property type="entry name" value="DSP_fungal_YVH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016278">
        <property type="entry name" value="DUSP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000941">
        <property type="entry name" value="DUSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="4"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="8">
        <location>
            <begin position="111"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="5">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000941-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ87099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="389" mass="42808" checksum="FF8A06C204E7B1FE" modified="2006-03-21" version="1">MAVNRINGHEELYVGGVFGINRARLQEHNITHILSVIKYTLNRDDDAFRNVEHLSIDIDDMDDQDILVQLPRLVRFINRGLHPGKSTPDNDNNGEALSTTEITPSPDSAAPSSPGAVLVHCAMGKSRSATAVVAYLLWKHPHRFGKAKPTTTAQQAVAQAVEWVRKTRPLAEPNDGFMRQLEIWWDMGCPAGSDDAVEKEPTYQRWLYKREVEDAARIGRAPEWIRFEDEETTGGAVKATEASTGIELRCKKCRRVLATGPFIVPHHGTDEVGRADCPHFFIEALSWMRPILDEGALDGRLICPNAKCSASIGRYAWQGFKCSCGEWVAPAFSLQNSKVDKVVKGRQGAGAGAVTERMAALGIRMPPGAARVPPAATPDHVAERYKGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3I3</accession>
    <name>Q2H3I3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_06782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222877.1">
        <property type="nucleotide sequence ID" value="XM_001222876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3I3"/>
    <dbReference type="GeneID" id="4390630"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06782"/>
    <dbReference type="eggNOG" id="ENOG502S90D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096188_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H3I3"/>
    <dbReference type="OMA" id="STLHKWR"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02231">
        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047142">
        <property type="entry name" value="OryJ/VirC-like"/>
    </dbReference>
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        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156:SF2">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156">
        <property type="entry name" value="SLR2101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="2">
        <location>
            <begin position="135"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ90163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="213" mass="22812" checksum="33FB306A47BCAB71" modified="2006-03-21" version="1">MTDTNTNTAPDTQAAESPFGPPIRYITTHDPATGKSVFTTALPTEVPGFSMPGLAIFDAYKTLTSPVSLNDEADLAALQPQPPSTSSSHPPPPNTTTTATPSSLPNPNNTTTTPTEPAIWFPTSHPHTQTLLRYCDFPPGASSPLHRTETLDMGVVVAGQAEVRLDSGEARTLRVGDSIIQRGTMHAWRNVSEREWVRLVVFLVGVDEVRVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H400</accession>
    <name>Q2H400_CHAGB</name>
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        <recommendedName>
            <fullName evidence="3">UAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_06615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222710.1">
        <property type="nucleotide sequence ID" value="XM_001222709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H400"/>
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        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H400"/>
    <dbReference type="GeneID" id="4391126"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06615"/>
    <dbReference type="eggNOG" id="KOG1363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020031_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H400"/>
    <dbReference type="OMA" id="VYAFVEC"/>
    <dbReference type="OrthoDB" id="1026733at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UAS" evidence="3">
        <location>
            <begin position="183"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ89996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="514" mass="57061" checksum="3DBD70A780183139" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H421</accession>
    <name>Q2H421_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="11">40S ribosomal protein S9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_06594</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001222688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H421"/>
    <dbReference type="FunCoup" id="Q2H421">
        <property type="interactions" value="959"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H421"/>
    <dbReference type="GeneID" id="4390076"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06594"/>
    <dbReference type="eggNOG" id="KOG3301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089738_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H421"/>
    <dbReference type="OMA" id="RQFITHG"/>
    <dbReference type="OrthoDB" id="1697570at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000021">
        <property type="entry name" value="40S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003139">
        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="10">
        <location>
            <begin position="5"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="9">
        <location>
            <begin position="105"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="159"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ89975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="191" mass="21991" checksum="7B7E029B0836AD59" modified="2006-03-21" version="1">MAPLSYSKTAKVPRRPFEAARLDSELKLVGEYGLRNKREVWRVLLTLSKIRRAARELLTLDEKDPKRLFEGNALIRRLVRVGVLDESRMKLDYVLALKAEDFLERRLQTLVYKLGLAKSIHHARVLIRQRHIRVGKQIVNVPSFVVRLDSQKHIDFALTSPFGGGRPGRVRRKKAKAAEKGDGEEEEEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H428</accession>
    <name>Q2H428_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytoskeleton assembly control protein Sla2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_06587</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLA2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222682.1">
        <property type="nucleotide sequence ID" value="XM_001222681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H428"/>
    <dbReference type="FunCoup" id="Q2H428">
        <property type="interactions" value="218"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H428"/>
    <dbReference type="GeneID" id="4390342"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06587"/>
    <dbReference type="eggNOG" id="KOG0980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004601_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H428"/>
    <dbReference type="OMA" id="FQMSVEM"/>
    <dbReference type="OrthoDB" id="10262320at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17007">
        <property type="entry name" value="ANTH_N_Sla2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1410.10:FF:000004">
        <property type="entry name" value="Cytoskeleton assembly control protein Sla2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000021">
        <property type="entry name" value="Cytoskeleton assembly control protein Sla2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030224">
        <property type="entry name" value="Sla2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407:SF15">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="7">
        <location>
            <begin position="8"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="I/LWEQ" evidence="8">
        <location>
            <begin position="771"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="268"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="357"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ89968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1013" mass="114045" checksum="1EF44F0974900FB6" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4A3</accession>
    <name>Q2H4A3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">malate synthase</fullName>
            <ecNumber evidence="3">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_06512</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the malate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="3"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222607.1">
        <property type="nucleotide sequence ID" value="XM_001222606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4A3"/>
    <dbReference type="STRING" id="306901.Q2H4A3"/>
    <dbReference type="GeneID" id="4389967"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06512"/>
    <dbReference type="eggNOG" id="KOG1261">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104819_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4A3"/>
    <dbReference type="OMA" id="SHLIACP"/>
    <dbReference type="OrthoDB" id="186072at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1220.12:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="entry name" value="Malate synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="entry name" value="Malate synthase, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048355">
        <property type="entry name" value="MS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902:SF1">
        <property type="entry name" value="MALATE SYNTHASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20659">
        <property type="entry name" value="MS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="MS_TIM-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="Malate synthase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Malate synthase TIM barrel" evidence="9">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase C-terminal" evidence="10">
        <location>
            <begin position="83"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ89893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="197" mass="21591" checksum="8AE0CD5E7AF901F4" modified="2006-03-21" version="1">MAAQIPIKDDPAANEKAMAGVRADKLREVRAGHDGTWVAHPALAAIASDIFNQHMPTPNQLFVRREDVTIGANDLLNMNVPGKITEEGIRKNLNIGLGYMEAEDAATAEVSRSQLWQWVRHGVTTAEGKRVDKSYALKLLKEQAQELASKAPKGNKYQLAAQYFAGQVTGEDYADFLTSLLYDEITSQEAPKPASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4C4</accession>
    <name>Q2H4C4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CREG-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_06491</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222586.1">
        <property type="nucleotide sequence ID" value="XM_001222585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4C4"/>
    <dbReference type="GeneID" id="4390642"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06491"/>
    <dbReference type="eggNOG" id="ENOG502RDU8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056802_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H4C4"/>
    <dbReference type="OMA" id="ITLSMRW"/>
    <dbReference type="OrthoDB" id="2138282at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CREG_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273:SF1">
        <property type="entry name" value="ADL397C-AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13883">
        <property type="entry name" value="CREG_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209260" description="CREG-like beta-barrel domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="CREG-like beta-barrel" evidence="3">
        <location>
            <begin position="33"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ89872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="282" mass="30795" checksum="1D2AD1911CA1626B" modified="2006-03-21" version="1">MRPALASTLIFCTAASTAAAAVVSAPANELRIPTSYESAVLGRRILALTPLGTLSTVFPEDKNSNDASAQERRPPGLGGMPYGLMEYIADCETDDAGNPTILAIAIGTTFKNAAAGSNVSLAVQWAPPHPPAKRIKSGRKSWFSFLDLFGAAEDAHYHHHHYHDIPLPYSAANLPRFSLLGHLEAIEGGDDRDGEVGAALASCYVKSHPDARYWLPGNRIHEAHFVRLVVEQVYWVGGFGDRAFIGWIPVAEWQNVTREEWQRARLPGEKKGWKEWSAQGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4E8</accession>
    <name>Q2H4E8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Myosin class II heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_06467</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222562.1">
        <property type="nucleotide sequence ID" value="XM_001222561.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H4E8"/>
    <dbReference type="GeneID" id="4391187"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06467"/>
    <dbReference type="eggNOG" id="ENOG502QRRG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001004_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4E8"/>
    <dbReference type="OMA" id="WGFAYDK"/>
    <dbReference type="OrthoDB" id="1293114at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083:SF0">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="241"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
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        <location>
            <begin position="598"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="647"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="760"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="865"/>
            <end position="906"/>
        </location>
    </feature>
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        <location>
            <begin position="976"/>
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        </location>
    </feature>
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            <begin position="1018"/>
            <end position="1038"/>
        </location>
    </feature>
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            <begin position="1129"/>
            <end position="1237"/>
        </location>
    </feature>
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        <location>
            <begin position="1258"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1413"/>
            <end position="1444"/>
        </location>
    </feature>
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        <location>
            <begin position="2181"/>
            <end position="2317"/>
        </location>
    </feature>
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        <location>
            <begin position="1520"/>
            <end position="1641"/>
        </location>
    </feature>
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            <begin position="1674"/>
            <end position="1701"/>
        </location>
    </feature>
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            <begin position="1751"/>
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            <begin position="2112"/>
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        </location>
    </feature>
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        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
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        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
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        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
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        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
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        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
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        <location>
            <begin position="764"/>
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        </location>
    </feature>
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        <location>
            <begin position="982"/>
            <end position="999"/>
        </location>
    </feature>
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        <location>
            <begin position="1157"/>
            <end position="1168"/>
        </location>
    </feature>
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        <location>
            <begin position="1413"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2191"/>
            <end position="2208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2219"/>
            <end position="2243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="2299"/>
            <end position="2317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ89848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2317" mass="254177" checksum="A159F6E49E55FA39" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4G4</accession>
    <name>Q2H4G4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222546.1">
        <property type="nucleotide sequence ID" value="XM_001222545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4G4"/>
    <dbReference type="STRING" id="306901.Q2H4G4"/>
    <dbReference type="GeneID" id="4391153"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06451"/>
    <dbReference type="eggNOG" id="KOG3089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1740303_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4G4"/>
    <dbReference type="OrthoDB" id="1929311at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032704">
        <property type="entry name" value="Cms1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030:SF0">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14617">
        <property type="entry name" value="CMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="150" mass="17000" checksum="FD8DF83FDD4FED81" modified="2006-03-21" version="1">MTTEEQSKKRKVQDDDKPRKKQKKQKKVREDEGDLDVEAGLNRAFERMDGQLAADYIAQKTRRFGTDLSPVELSDLYISANHIKDSTSWEKPRSLENLADFLEAFAGESEKLDRAPKKNGSPHTLIVAGAGLRAADLVRYERLLKLSRPS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-23" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4X9</accession>
    <name>NACB_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Nascent polypeptide-associated complex subunit beta</fullName>
            <shortName>NAC-beta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>Beta-NAC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">EGD1</name>
        <name type="ORF">CHGG_06286</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the nascent polypeptide-associated complex (NAC), consisting of EGD2 and EGD1. NAC associates with ribosomes via EGD1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <text evidence="1">Predominantly cytoplasmic, may also transiently localize to the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAC-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222381.1">
        <property type="nucleotide sequence ID" value="XM_001222380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4X9"/>
    <dbReference type="SMR" id="Q2H4X9"/>
    <dbReference type="FunCoup" id="Q2H4X9">
        <property type="interactions" value="1095"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H4X9"/>
    <dbReference type="GeneID" id="4391309"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06286"/>
    <dbReference type="eggNOG" id="KOG2240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098726_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H4X9"/>
    <dbReference type="OMA" id="AGDTYME"/>
    <dbReference type="OrthoDB" id="8033832at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="entry name" value="Nascent polypeptide-associated complex subunit beta"/>
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        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER"/>
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    </dbReference>
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        <property type="entry name" value="NAC"/>
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        <property type="entry name" value="NAC_AB"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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            <begin position="1"/>
            <end position="150"/>
        </location>
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        <location>
            <begin position="36"/>
            <end position="101"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="150" mass="16411" checksum="9B2DC2D9A3103906" modified="2006-03-21" version="1">MADVQERLKKLGASARIGTGKGTPRRKVKRAPARSGADDKKLQQSLKKLNVQPIQAIEEVNMFKSDGNVIHFAAPKVHAAVPSNTFAIYGNGEDKELTELVPGILNQLGPDSLASLRKLAESYQNMQQKKDDDDEIPDLVAGESFENKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H537</accession>
    <name>Q2H537_CHAGB</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">CHGG_06228</name>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
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                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ89609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001222322.1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06228"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_18_0_1"/>
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    <dbReference type="OMA" id="ANPHMTD"/>
    <dbReference type="OrthoDB" id="4590798at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2"/>
            <end position="34"/>
        </location>
    </feature>
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        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
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            <begin position="68"/>
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        </location>
    </feature>
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        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
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        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="168"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ89609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="237" mass="26429" checksum="3919BCD42F9959DA" modified="2006-03-21" version="1">MSDRSLLIHAVRNGHPDTVRLLLEKGADIDRRDRNSRTPLWHAVERGHLDVVTLLLEKGADIAEKDYFGQTPIHYAAEKGNPRMVLLLFKKGADIGKADRWGHSPIWYAAREMRLKTVILPLLESGLHIDFKDENGRTLLSHATSAGDESAIKVLLQKGANIEQRDKDGLTPLSWAARWGQEATLRILVGSGAQIDVKDEQGRTPLSWAADTVASEARTRDKPLWQSYFVGILSDPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H576</accession>
    <name>Q2H576_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_06189</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222284.1">
        <property type="nucleotide sequence ID" value="XM_001222283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H576"/>
    <dbReference type="FunCoup" id="Q2H576">
        <property type="interactions" value="238"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H576"/>
    <dbReference type="GeneID" id="4390659"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06189"/>
    <dbReference type="eggNOG" id="KOG2722">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026460_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H576"/>
    <dbReference type="OMA" id="WSWGYHI"/>
    <dbReference type="OrthoDB" id="2499604at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794:SF2">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="488"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="258"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ89570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="586" mass="65119" checksum="23EE97B641DE6CAE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5V6</accession>
    <name>Q2H5V6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable endonuclease LCL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Probable endonuclease lcl3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CHGG_05959</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LCL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222054.1">
        <property type="nucleotide sequence ID" value="XM_001222053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5V6"/>
    <dbReference type="STRING" id="306901.Q2H5V6"/>
    <dbReference type="GeneID" id="4390178"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05959"/>
    <dbReference type="eggNOG" id="ENOG502S1U4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_531195_0_0_1"/>
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    <dbReference type="OrthoDB" id="430293at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000029">
        <property type="entry name" value="Probable endonuclease lcl3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="TNase-like" evidence="16">
        <location>
            <begin position="285"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="448"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAQ89340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="482" mass="54503" checksum="6B92B05706CF6EF1" modified="2006-03-21" version="1">MCYHRRLIFGCNHHAWLEITKPCEVEEAFNSGQADTGCDRQWSHPFHVIRIQSKCDQCVKRQKGDSFQLGTVKDRIKAIKERLERIKGKKELPSIDTVLQESESGAKEGADDTSLLEEMADTSDKEYRAVEEDPKHWPLKLPSIIAERETKEVNAVTVVSRKAIARGSRAETSEPESHGRRRKESDIEMWVDERWKCPFYGGSRTNDMLPAYEMTGNDREAAWSFKRKNGDSWADAIRHHLSFPQNWIVPVAAVAIALGARSFYQSYLHRLPASSHITHSFFRNRSLFGKVTSVGDGDGFHLFHTPGGRLAGWGWLRRVPTDKKQLKGQTISIRIAGVDAPEGAHFGRPAQPFAAEALTFLESYLLGRRVRAHLHRRDQYERVVATAYVRRPPFFVPRRDVGLEMLRRGLAVTYEGKTGAEFGGAEVEARYREAEAEAKRKGVGLWAGSAKRAGSAEGGKKKKELESPMEYKKRMKALEGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7X3</accession>
    <name>Q2H7X3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230197.1">
        <property type="nucleotide sequence ID" value="XM_001230196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7X3"/>
    <dbReference type="GeneID" id="4388751"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03681"/>
    <dbReference type="HOGENOM" id="CLU_1427816_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7X3"/>
    <dbReference type="OrthoDB" id="4754366at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="190" mass="21274" checksum="586039FFC7939C19" modified="2006-03-21" version="1">MPLQPSERGARETTGDLPPGEEAEAEMILGNLLSDLPAELRRQEKQRLSGLVALRVLVTHPFFDRCPGLLVIAVQYAVKLRANDRHEWPFENPIESRFLDDMAAAFARPHPDRPARVIHKMVNQARNGKYTPLMSVVLQEIEKAVDTPNVAFQGLTDPFDRYSVTTTDLRNVATALNNVRSCGVAIYLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H848</accession>
    <name>Q2H848_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_03606</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230122.1">
        <property type="nucleotide sequence ID" value="XM_001230121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H848"/>
    <dbReference type="STRING" id="306901.Q2H848"/>
    <dbReference type="GeneID" id="4389451"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03606"/>
    <dbReference type="eggNOG" id="KOG1185">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_4_0_1"/>
    <dbReference type="InParanoid" id="Q2H848"/>
    <dbReference type="OMA" id="DMCFPGD"/>
    <dbReference type="OrthoDB" id="2867507at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF164">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="4">
        <location>
            <begin position="210"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="5">
        <location>
            <begin position="418"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ91671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="591" mass="64510" checksum="087E9C99A90A0493" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8T1</accession>
    <name>Q2H8T1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229889.1">
        <property type="nucleotide sequence ID" value="XM_001229888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8T1"/>
    <dbReference type="STRING" id="306901.Q2H8T1"/>
    <dbReference type="GeneID" id="4388487"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03373"/>
    <dbReference type="eggNOG" id="ENOG502SEUQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106353_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8T1"/>
    <dbReference type="OMA" id="NGWFVAS"/>
    <dbReference type="OrthoDB" id="3990500at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="192" mass="20485" checksum="5578B5BBB118B2A6" modified="2006-03-21" version="1">MATRTLTRSALHTRLTTTTAPTAALRRLSLRHAALPLGLGLTTGLVAVHQQRPMRFDSAAVLTPQARAYSSKGDRDRKELLDGETVKQLSGGSLSGMDPPVLEGVCVMSGWMCANASGVWGSRVRCGDVGERVLQDAGAAGGDRDGAYPDIVSYLKLKERASTSRIVALLNQHTAFKFSFAIAFALSAFMSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9F6</accession>
    <name>Q2H9F6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myotubularin phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_03148</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229664.1">
        <property type="nucleotide sequence ID" value="XM_001229663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9F6"/>
    <dbReference type="FunCoup" id="Q2H9F6">
        <property type="interactions" value="345"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H9F6"/>
    <dbReference type="GeneID" id="4389028"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03148"/>
    <dbReference type="eggNOG" id="KOG1089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001839_5_1_1"/>
    <dbReference type="InParanoid" id="Q2H9F6"/>
    <dbReference type="OMA" id="WLAHIAN"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF128">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="4">
        <location>
            <begin position="69"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="452"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="621"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="709"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="633"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="717"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="739"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="1">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="287"/>
            <end position="288"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="351"/>
            <end position="357"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ91213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="757" mass="83960" checksum="883519D6551D83F6" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9M4</accession>
    <name>Q2H9M4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229596.1">
        <property type="nucleotide sequence ID" value="XM_001229595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9M4"/>
    <dbReference type="GeneID" id="4389345"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03080"/>
    <dbReference type="eggNOG" id="ENOG502QVGS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1077697_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9M4"/>
    <dbReference type="OMA" id="FMCASFA"/>
    <dbReference type="OrthoDB" id="5427833at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="258" mass="26369" checksum="1C3D9A6F3839B6BA" modified="2006-03-21" version="1">MESSVLTGLEEVQGHFPLAEPEEKGHECSTSTVSAIPLSKFEPITATTISLGCILAYNVEIPGCAISDFVAGNACSASCVRGLKRVEANLASACDRTEVSEISVLGQALLGNLVELLCPGTSSPENPVSSPTAAPTTFTTRRSSSPPPLTFTPVRPSSTTTTAVTETEEPETSTSTSRASPTTTTPQTFIQSSPPTSSPSSDSTSTPEPPAEDSGGSSGGGTPFDNPFDNAGSGSRQATACWVQAMAIGLGVGLLLLR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-03" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9N4</accession>
    <name>EIF3L_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="1">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">CHGG_03070</name>
    </gene>
    <organism>
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229586.1">
        <property type="nucleotide sequence ID" value="XM_001229585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9N4"/>
    <dbReference type="SMR" id="Q2H9N4"/>
    <dbReference type="STRING" id="306901.Q2H9N4"/>
    <dbReference type="GeneID" id="4388787"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03070"/>
    <dbReference type="eggNOG" id="KOG3677">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029210_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H9N4"/>
    <dbReference type="OMA" id="AGWFIRN"/>
    <dbReference type="OrthoDB" id="15082at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000364262" description="Eukaryotic translation initiation factor 3 subunit L">
        <location>
            <begin position="1"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="255"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01185"/>
        </source>
    </evidence>
    <sequence length="474" mass="54754" checksum="2308E16FEFC0C75F" modified="2006-03-21" version="1">MSYQTGMAPARAMEDDSDVEEEALVADYREQVQYSEGGMEEMDQATLAQQADEIQSRLVQASQPLDFQATLETKFASYDNYCALFHYILNSEGPVDLEPPTYYWAWDVIDEFIYQFNTFCTYRARIARQAGNEEEAQILRDNPNTWGCYSVLNVLYSLIQKSQITEQLAAMKRNEDPMAVAGPYGSKNLYRMLGYFSIIGLLRVHCLLGDFSLALKTLDDIELNKKAMFARVMAAHFTTYYYVGFSYMMMRRYADAIRMFSHILIYVSRTKNFQKNTQYDSITKKNDQMLALIAICVAFHPTRLDDTIHTALREKYGDQLLKLQRGGPDSLPVFEELFKSACPKFMSPIPPDFDKPEANIDPIDHHLSVFMEEVKTNMWSPTVKSYLRLYTTMDLKKLAGFLDVKPEELRSWLLVSKQRTKQLRWTENGLLEGEPVNVSDLDYALQGDLIHISEAKMGRKLVDWYIRNLSRTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9Z7</accession>
    <name>Q2H9Z7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_02957</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229473.1">
        <property type="nucleotide sequence ID" value="XM_001229472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9Z7"/>
    <dbReference type="STRING" id="306901.Q2H9Z7"/>
    <dbReference type="GeneID" id="4389751"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02957"/>
    <dbReference type="eggNOG" id="ENOG502S3WQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_498740_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9Z7"/>
    <dbReference type="OrthoDB" id="2924818at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="6">
        <location>
            <begin position="27"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="277"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="497"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="27"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ91022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="546" mass="56963" checksum="763F34D04D04B9BA" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAB2</accession>
    <name>Q2HAB2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_02842</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229358.1">
        <property type="nucleotide sequence ID" value="XM_001229357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAB2"/>
    <dbReference type="STRING" id="306901.Q2HAB2"/>
    <dbReference type="GeneID" id="4389579"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02842"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013258_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HAB2"/>
    <dbReference type="OMA" id="NTHEQHI"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="365"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="595"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="429"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ90907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="616" mass="64727" checksum="2CB189A45633CA21" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAS5</accession>
    <name>Q2HAS5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_02679</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229195.1">
        <property type="nucleotide sequence ID" value="XM_001229194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAS5"/>
    <dbReference type="STRING" id="306901.Q2HAS5"/>
    <dbReference type="GeneID" id="4389204"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02679"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_3_1"/>
    <dbReference type="InParanoid" id="Q2HAS5"/>
    <dbReference type="OMA" id="FWGLHRV"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF238">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01680)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="14"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="306"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ90744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="441" mass="48973" checksum="84AE8B191F2E64B2" modified="2006-03-21" version="1">MGVQTDSKEGIHLIIIGAGLAGLSAALSTKLANPAHRVTVLEAVNELQEVGAGLQLTPNGTRLLKAWSLDERLAPLAAVPSSLSMRRYDGSKLLAHEADLQGQMRARYGAGAPFWDLHRVDLQQAMVARCEALGVEIRLGSRVVAVDFAEARVRLAQGGLVLRGDVVLLADGLWSAIRPAFLGRPSPAVPTGDLAYRITIRVDQLEGEDAEELRRFIRDATVNFWIGPRSHCVGYSVRAGEMYNLVFLCPDDLPKDVAKLEGDMDEMRARFGGWDPLLGRFLKQVKGVVHKWRLMWLDALPEWTNKEGTFFMAGDCCHPMLPYLAQGANSSLEDGAVLGSLLGRVRKSEMAKQLPSVSVLYQKLRRERGRKIQLETFKQRDDSHMEDGEAQEKRDALMVSMLGKELKAPFPSRWTCPEIQPFLYGYDAYAEAEKGYRENPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCA6</accession>
    <name>Q2HCA6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228664.1">
        <property type="nucleotide sequence ID" value="XM_001228663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCA6"/>
    <dbReference type="GeneID" id="4389844"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02148"/>
    <dbReference type="HOGENOM" id="CLU_2209728_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCA6"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="107" mass="12131" checksum="50E46240F921A751" modified="2006-03-21" version="1">MPLHLHKENGSAPPMWRAAEMPCTLSFYLTHKGTLAERGAKPIRWQEHFMRFLYTSLVGRCPLAQHIRCALAAVKVRRQARLSGPHVEGGNDSRIKKRRAGRFGPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCR8</accession>
    <name>Q2HCR8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221207.1">
        <property type="nucleotide sequence ID" value="XM_001221206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCR8"/>
    <dbReference type="GeneID" id="4386233"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01986"/>
    <dbReference type="eggNOG" id="ENOG502RXTA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014722_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCR8"/>
    <dbReference type="OMA" id="DHVSYPE"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF13">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209132" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="33"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="337" mass="37488" checksum="403A51FC0E3BAA04" modified="2006-03-21" version="1">MKWNSITAALGLAAPASALLRFGCARLTIQRLDPLVTPGQNPSPHLHQIIGGDSFNVSMDHPSHDLVKQSKCTSCQFTEDFSNYWTAVLYFRARNGTFKRVPQIAQAGMEGTQAQVVYYMSDALFDTAQRSSVTAFKPGFRMLVGDASYKTRDQARDFRQLTYTCMENQASRQPESIGFPKTPCKLGIMANHRFPTCWDGVNLDTPNHQDHVAYPETGTFESGGPCPASHPVRLPQILLETVWDTSAFNRAEDWPADGSQPFVWSNGDSTGFSSHADYVFGWQDDSLQRAMDAHTYVSAPMLKTQSIAQQNKCVAKDMVHEDFDGWLKELPGGNTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HD55</accession>
    <name>Q2HD55_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Basic proline-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221070.1">
        <property type="nucleotide sequence ID" value="XM_001221069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HD55"/>
    <dbReference type="STRING" id="306901.Q2HD55"/>
    <dbReference type="GeneID" id="4386317"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01849"/>
    <dbReference type="eggNOG" id="ENOG502S9W4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046290_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HD55"/>
    <dbReference type="OMA" id="KYNESYP"/>
    <dbReference type="OrthoDB" id="5400063at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="30822" checksum="B93304D813D615B6" modified="2006-03-21" version="1">MEPVPETERMEEFRPSPLPSLRLPATTSLAPEFDSLRKPPTIRRSTDPSPSSPISPSWMPPALPHRPRASSPLSSNHVRSRSAASLAPPMGRTQSMPGTNATGHLLFSPHIRPQSPSGSPSRVRLPRKPVDEGFPSSPTRISVLDPERKISEGSSSPNQALGITPIASVPKLRRPSSPLSYGYYPSSSVPSTPTSARSRSPSISSLETIPDSPDAEEAALESERIAQLKAAADAAEGGETKGRGSLDVPTRGRTLSGFGSRDKRKRWSVCGAERRQDLDLETIWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDD4</accession>
    <name>Q2HDD4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannose-P-dolichol utilization defect 1 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_01770</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220991.1">
        <property type="nucleotide sequence ID" value="XM_001220990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDD4"/>
    <dbReference type="STRING" id="306901.Q2HDD4"/>
    <dbReference type="GeneID" id="4386277"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01770"/>
    <dbReference type="eggNOG" id="KOG3211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053568_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HDD4"/>
    <dbReference type="OMA" id="LQVLYYW"/>
    <dbReference type="OrthoDB" id="271506at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000006">
        <property type="entry name" value="mannose-P-dolichol utilization defect 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023381">
        <property type="entry name" value="MannP-dilichol_defect-1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="251"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR023381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ93535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="284" mass="30006" checksum="BAF16DBF04564504" modified="2006-03-21" version="1">MDALRSAIQPITHNLPGPIRDLGESIIGDACYKALLLDVDLENTACVKLAVSKGLGIGIVGASSIVKVPQILKLVQSQSASGVSFLSYLLETSSYLISLVYNVRNAFPFSTYGETALVLGQNVIITVLVLNYSGRASMAALFVAALAASVVTLFSENLVDMQNLRYLQAGAGALGVASKVPQILAILQEGGTGQLSAFTVFNYLLGSLARVFTTLQEVDDKLILYGFVAGFALNLVLALQMVYYWNAPSAKAKGKQKEVPVAAPVSATTTSTPKSKGPTTRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HE50</accession>
    <name>Q2HE50_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220725.1">
        <property type="nucleotide sequence ID" value="XM_001220724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HE50"/>
    <dbReference type="GeneID" id="4388193"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01504"/>
    <dbReference type="HOGENOM" id="CLU_1030587_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HE50"/>
    <dbReference type="OMA" id="PTSENHR"/>
    <dbReference type="OrthoDB" id="10438446at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="270" mass="30175" checksum="E5B8ABA04B36CFDE" modified="2006-03-21" version="1">MAYFDTIHNASTFQEKALSKKGQKTKLNRQARGTRRAPLPLLEPYLVNETPSRPDIQALIGGPVLNLQVLPMLSDAHFVLGYGRSGIGFVWAQLGALLQRQGDEDNQEQEEPRAGGTKSRRNQEQEEPRAGGDMENPQGTGVEDTEIDDLTLHLARFFVRVVLIWSQQLYIQLPDEQAVAETRVERVSANYQLQSGSNCILWAVEDGGVRLLSLPGLKDSRIVALMETKQRFQDLEDGKPVISDGLLAQMAGQALLVLLDKRRRTIFDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HED4</accession>
    <name>Q2HED4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_01420</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220641.1">
        <property type="nucleotide sequence ID" value="XM_001220640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HED4"/>
    <dbReference type="FunCoup" id="Q2HED4">
        <property type="interactions" value="645"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HED4"/>
    <dbReference type="GeneID" id="4387451"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01420"/>
    <dbReference type="eggNOG" id="KOG2667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034705_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HED4"/>
    <dbReference type="OMA" id="QRHEGCR"/>
    <dbReference type="OrthoDB" id="270930at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061852">
        <property type="term" value="C:retrograde transporter complex, Golgi to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="9">
        <location>
            <begin position="8"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="8">
        <location>
            <begin position="143"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ93185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="438" mass="48511" checksum="84156F409E34C6A3" modified="2006-03-21" version="1">MPPKSRFTRLDAFTKTVEDARIRTTSGGIVTIVSLVVVFFLAWGEWSDYRRVEVHPELIVDKGRGERMEIHLNITFPRIPCELLTLDVMDISGEQQHGVQHGVTKTRLRPQSEGGGDIDTKAVALHARDEVATHLDPSYCGPCYGAQPPPNAKKPGCCNTCEEVKDAYAQAAWAFGRGEGIEQCEREHYSEKLDEQRNEGCRIEGGLRVNKVIGNFHIAPGRSFSNGNMHVHDLKNYWDTPTKHTFSHQIHHLRFGPQLPDNLHKKLDARKNMRGRSTTFNPLDDTPPGDGTTSTTTTCTSSRSCPHRTCRWAGRKTWAGFREEHHAELGSFGASADGSVETHQYSVTSHKRSLAGGDDSAEGHQERLHARGGIPGVFFSYDISPMKVINREEKAKSFLGFIAGLCAIVGGTLTVAAAIDRALFEGGVRLKKMRSKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFE8</accession>
    <name>Q2HFE8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Meiotically up-regulated protein Msb1/Mug8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220277.1">
        <property type="nucleotide sequence ID" value="XM_001220276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFE8"/>
    <dbReference type="STRING" id="306901.Q2HFE8"/>
    <dbReference type="GeneID" id="4386794"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01056"/>
    <dbReference type="eggNOG" id="ENOG502RBV5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006014_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HFE8"/>
    <dbReference type="OMA" id="VVGWDAY"/>
    <dbReference type="OrthoDB" id="3362494at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037508">
        <property type="entry name" value="Msb1/Mug8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012965">
        <property type="entry name" value="Msb1/Mug8_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093:SF1">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08101">
        <property type="entry name" value="Msb1-Mug8_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meiotically up-regulated protein Msb1/Mug8" evidence="2">
        <location>
            <begin position="42"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="793"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="822"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ92821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="993" mass="108577" checksum="2DA4CB22A6B3CF84" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFM8</accession>
    <name>Q2HFM8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_00976</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220197.1">
        <property type="nucleotide sequence ID" value="XM_001220196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFM8"/>
    <dbReference type="FunCoup" id="Q2HFM8">
        <property type="interactions" value="1201"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HFM8"/>
    <dbReference type="GeneID" id="4386819"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00976"/>
    <dbReference type="eggNOG" id="KOG0815">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053173_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HFM8"/>
    <dbReference type="OMA" id="DMNPFKL"/>
    <dbReference type="OrthoDB" id="10259902at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="109"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="275"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ92741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="311" mass="33407" checksum="49B710F80BB71958" modified="2006-03-21" version="1">MGGKSGNKAGYFDKLKSLLEEYASIFIVSVDNVSSQQMHEIRQSLRGNGVVLMGKNTMVRRALKTFLADSPEYERLLPFVKGNIGFVFTNSDLKEIRDKILANKVAAPARAGAVAPSDVWIPAGNTGMEPGKTSFFQALGVPTKIARGTIEITTDLKLVEAGLKVGPSEATLLNMLNISPFTYGMGITQVYDHGNAFPADVLDIGEEQLLKSFSSAITTVAAISLALNFPTLPSVIHSVVNSYKKVLAIAIETDFSWPEIDELKDRIANPDAYAAAAPVAEAAGPAETKAEEKEESEKEESDDEGFGGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGA7</accession>
    <name>Q2HGA7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Chitin-binding type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CHGG_00747</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219968.1">
        <property type="nucleotide sequence ID" value="XM_001219967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGA7"/>
    <dbReference type="GeneID" id="4386899"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00747"/>
    <dbReference type="eggNOG" id="ENOG502STNY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042696_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGA7"/>
    <dbReference type="OMA" id="CDQTTGY"/>
    <dbReference type="OrthoDB" id="1193027at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF1">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 16" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="13 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 17" id="KW-0349">Heme</keyword>
    <keyword evidence="11 17" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 19" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209160" description="Chitin-binding type-1 domain-containing protein" evidence="19">
        <location>
            <begin position="27"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="21">
        <location>
            <begin position="72"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="20">
        <location>
            <begin position="183"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="22">
        <location>
            <begin position="330"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="22">
        <location>
            <begin position="491"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="293"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="17">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="385"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="535"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="544"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EAQ92512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="25">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="60446" checksum="74882DD8CBEFB804" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGH6</accession>
    <name>Q2HGH6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219899.1">
        <property type="nucleotide sequence ID" value="XM_001219898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGH6"/>
    <dbReference type="STRING" id="306901.Q2HGH6"/>
    <dbReference type="GeneID" id="4386782"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00678"/>
    <dbReference type="eggNOG" id="ENOG502QWDP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HGH6"/>
    <dbReference type="OMA" id="TWFREIN"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF14">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="34060" checksum="1000575641F1E3D3" modified="2006-03-21" version="1">MAPPASINMSVHSADRPLDNYQFTFESYLDDSAQIEPDQAYLFPNDNPENDRVDEQYEIIKMIMDGRLHLAPFSDDRPPRRVLDIATGTGIWAIEMGDKYPEAEIIGTDLSPIQPGFVPPNVRFFIEDSRDDWDYPAKFDFIHTRVTLGCWSDMKNEIIQRSFDHLQPGGWLECQEIPAPVMCDDGTLPEDFGWLRWVRDFRAGGQVANRQVDLGPQLTGWMHEVGFVDIHEMTFKIPINGWPKEMRLKHIGMMWQRNLLEGLSGFSLGMFNQLGKTVEEIETSVLSDTGFRGAHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH36</accession>
    <name>Q2HH36_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_00468</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219689.1">
        <property type="nucleotide sequence ID" value="XM_001219688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH36"/>
    <dbReference type="STRING" id="306901.Q2HH36"/>
    <dbReference type="GeneID" id="4388025"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00468"/>
    <dbReference type="eggNOG" id="KOG3466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3032189_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HH36"/>
    <dbReference type="OrthoDB" id="13598at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="10">
        <location>
            <begin position="5"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ92233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="55" mass="6643" checksum="25958C2274EBFBFB" modified="2006-03-21" version="1">MSSRQAALSLYRRSLKLALDWSVQRHLWRGQALYIRSLFEKNRDVSDPRLQRVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH77</accession>
    <name>Q2HH77_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="2 12">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_00427</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="10 12">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="12">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="2 12"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219648.1">
        <property type="nucleotide sequence ID" value="XM_001219647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH77"/>
    <dbReference type="FunCoup" id="Q2HH77">
        <property type="interactions" value="969"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HH77"/>
    <dbReference type="GeneID" id="4387298"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00427"/>
    <dbReference type="eggNOG" id="KOG1335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HH77"/>
    <dbReference type="OMA" id="CAQLGMK"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:pyruvate dehydrogenase complex"/>
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        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:flavin adenine dinucleotide binding"/>
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        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
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        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
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        <property type="term" value="P:2-oxoglutarate metabolic process"/>
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        <property type="term" value="P:L-leucine catabolic process"/>
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        <property type="term" value="P:L-serine biosynthetic process"/>
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        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
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        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
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        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mercury_reductase_MerA"/>
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    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 12" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="35"/>
            <end position="360"/>
        </location>
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    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="13">
        <location>
            <begin position="379"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="477"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
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        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>FAD</name>
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        </ligand>
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        <location>
            <begin position="174"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>FAD</name>
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        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <begin position="211"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
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        <location>
            <position position="234"/>
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        <ligand>
            <name>NAD(+)</name>
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        </ligand>
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            <position position="304"/>
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            <position position="345"/>
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            <begin position="351"/>
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            <begin position="72"/>
            <end position="77"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF07992"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="EAQ92192.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="498" mass="53485" checksum="0352462594968D90" modified="2006-03-21" version="1">MLSQRLIGRTAVRSAFKPSGWHWPLKLTIHVESRDLVIIGGGVAGYVAAIKAGQEGMKVTCIEKRGTLGGTCLNVGCIPSKSLLNNSHLYHQILHDSKHRGIEVGDVKLNLAQLMKAKDQSVSGLTKGVEFLLKKNGVEYIKGAGSFQDEHTVKVQLNDGGETSVTGKNILIATGSEVTPFPGLQIDEKTVISSTGAIALEKVPKKMTVIGGGIIGLEMASVWSRLGSEVTVVEFLDQIGGPGMDTEIAKNIQKILKKQGIKFKTGTKVLGGEQSGEGVRVNVDSAKGGKEETFDADVVLVAIGRRPYTEGLGLENIGLELDERGRVIIDSEYRTKIPHIRCVGDATFGPMLAHKAEEEAVAAVEYIKKGYGHVNYGCIPSVMYTFPEVAWVGQSEQDLKKAGIKYRIGTFPFSANSRAKTNLDTEGMVKMLADPETDRLLGVHIIGPNAGEMIAEGTLALEYGASSEDIARTCHAHPTLAEAFKEAAMATYSKAIHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHT0</accession>
    <name>Q2HHT0_CHAGB</name>
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        <recommendedName>
            <fullName evidence="1">Rhamnogalacturonase A/B/Epimerase-like pectate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2005-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Giovannoni S.J."/>
                <person name="Cho J.-C."/>
                <person name="Ferriera S."/>
                <person name="Johnson J."/>
                <person name="Kravitz S."/>
                <person name="Halpern A."/>
                <person name="Remington K."/>
                <person name="Beeson K."/>
                <person name="Tran B."/>
                <person name="Rogers Y.-H."/>
                <person name="Friedman R."/>
                <person name="Venter J.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 148.51</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2006-02" db="EMBL/GenBank/DDBJ databases">
            <title>Annotation of the Chaetomium globosum CBS 148.51 Genome.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Birren B."/>
                <person name="Lander E."/>
                <person name="Galagan J."/>
                <person name="Devon K."/>
                <person name="Nusbaum C."/>
                <person name="Ma L.-J."/>
                <person name="Jaffe D."/>
                <person name="Butler J."/>
                <person name="Alvarez P."/>
                <person name="Gnerre S."/>
                <person name="Grabherr M."/>
                <person name="Kleber M."/>
                <person name="Mauceli E."/>
                <person name="Brockman W."/>
                <person name="Rounsley S."/>
                <person name="Young S."/>
                <person name="LaButti K."/>
                <person name="Pushparaj V."/>
                <person name="DeCaprio D."/>
                <person name="Crawford M."/>
                <person name="Koehrsen M."/>
                <person name="Engels R."/>
                <person name="Montgomery P."/>
                <person name="Pearson M."/>
                <person name="Howarth C."/>
                <person name="Kodira C."/>
                <person name="Yandava C."/>
                <person name="Zeng Q."/>
                <person name="Alvarado L."/>
                <person name="Oleary S."/>
                <person name="Untereiner W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 148.51</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219445.1">
        <property type="nucleotide sequence ID" value="XM_001219444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHT0"/>
    <dbReference type="STRING" id="306901.Q2HHT0"/>
    <dbReference type="GeneID" id="4388240"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00224"/>
    <dbReference type="eggNOG" id="ENOG502SH8Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002540_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HHT0"/>
    <dbReference type="OMA" id="WWGVAQA"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000049">
        <property type="entry name" value="Putative exo-beta-1,3-glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Pectin_lyas_fold"/>
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        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
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    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="1">
        <location>
            <begin position="138"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="1">
        <location>
            <begin position="456"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="818" mass="86992" checksum="2B086DD4BF573129" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HIE2</accession>
    <name>Q2HIE2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219233.1">
        <property type="nucleotide sequence ID" value="XM_001219232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HIE2"/>
    <dbReference type="GeneID" id="4388263"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00012"/>
    <dbReference type="HOGENOM" id="CLU_801674_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HIE2"/>
    <dbReference type="OrthoDB" id="3856898at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="346" mass="36879" checksum="3D21AACBF46BD60F" modified="2006-03-21" version="1">MPADLAKRTPQETIQAVNQVSVRKGAVAARRLPSGDTIVTFQSAGARDWYSTNTNWVREAFGEQAEESKRTFAVQLKGVWKTNLQGGGDPGNGAGRFNLPGGSTQGVRRGSDLEGSTTGLRALLGRPQPNAVLQVLEVGAHAALLQGDSIVPALRDPKPMERAAGKARPSALLTKTKFRYGARPAEEDIRRGQESARGKSKVLAKAKEAYQFRPRTYETVTTITAIATHTSAPTFSFGAEEREDDSYQVVGRKRLRGRPTNVAAAQRQALLDPQQTRINFEAPGVRFASPVVSGVDTTALPPRAPEPATGPTPTAAANPAVTATPNQRDAEGDTTMDSITVAGDEN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HIE9</accession>
    <name>ATM1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Iron-sulfur clusters transporter ATM1, mitochondrial</fullName>
            <ecNumber evidence="2">7.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ATM1</name>
        <name type="ORF">CHGG_00005</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins (By similarity). Hydrolyzes ATP (By similarity). Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219226.1">
        <property type="nucleotide sequence ID" value="XM_001219225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HIE9"/>
    <dbReference type="SMR" id="Q2HIE9"/>
    <dbReference type="FunCoup" id="Q2HIE9">
        <property type="interactions" value="613"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HIE9"/>
    <dbReference type="GeneID" id="4386662"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00005"/>
    <dbReference type="eggNOG" id="KOG0057">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_1_1"/>
    <dbReference type="InParanoid" id="Q2HIE9"/>
    <dbReference type="OMA" id="VFHIIPI"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140466">
        <property type="term" value="P:iron-sulfur cluster export from the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18582">
        <property type="entry name" value="ABC_6TM_ATM1_ABCB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000004">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF402">
        <property type="entry name" value="IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="4">
        <location>
            <begin position="1"/>
            <end status="unknown"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000255442" description="Iron-sulfur clusters transporter ATM1, mitochondrial">
        <location>
            <begin status="unknown"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="1">
        <location>
            <begin status="unknown"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="1">
        <location>
            <begin position="89"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="1">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="1">
        <location>
            <begin position="184"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="1">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="1">
        <location>
            <begin position="306"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="20"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="345"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="189"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="252"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P40416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q2G506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q9NP58"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4"/>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="603" mass="67070" checksum="10D87CC6264CC055" modified="2006-03-21" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GLY9</accession>
    <name>Q2GLY9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_11067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408038">
        <property type="protein sequence ID" value="EAQ82891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230243.1">
        <property type="nucleotide sequence ID" value="XM_001230242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GLY9"/>
    <dbReference type="STRING" id="306901.Q2GLY9"/>
    <dbReference type="GeneID" id="4397387"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_11067"/>
    <dbReference type="eggNOG" id="ENOG502S3SW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_860530_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GLY9"/>
    <dbReference type="OMA" id="VEHTINC"/>
    <dbReference type="OrthoDB" id="94039at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="80"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ82891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="323" mass="35589" checksum="94DAFFF60BAC2B56" modified="2006-03-21" version="1">MPQFFRVVEHTINCAHTREYVTATANGDADRPRLAVKQYIPLDNPNPQPGDVTIIAAHANGFPKVINPHGFNRFKASWWDHTRDLANLINLKRDEMPQPLVGIGHSMGGAQLTYLALCHPRLLHSLALLDPVITTTHSGIGPAAASTNRRDIWDSRAAAAARFAKSPFYRAWDPRVLDLWVRHGLRALPTELYPYPPGAARTSPTATTPNPNATDPPVTLTTTKHQELFTFLRPTYLPHRDLRDFDPSLLGLGPATNSAAKAPRTPSTARSRCTRSRACPSCAPACCTCLARRRRCRARRRGGPRWRGRGVGSGVVGAWRRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMA8</accession>
    <name>Q2GMA8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Very long-chain fatty acid transport protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Very-long-chain acyl-CoA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CHGG_10896</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities. Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226163.1">
        <property type="nucleotide sequence ID" value="XM_001226162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMA8"/>
    <dbReference type="FunCoup" id="Q2GMA8">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GMA8"/>
    <dbReference type="GeneID" id="4397249"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10896"/>
    <dbReference type="eggNOG" id="KOG1179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_46_3_1"/>
    <dbReference type="InParanoid" id="Q2GMA8"/>
    <dbReference type="OMA" id="VWRQFLD"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000019">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="FATTY ACID TRANSPORT PROTEIN 3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="22">
        <location>
            <begin position="69"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="23">
        <location>
            <begin position="511"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="589"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="590"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EAQ83078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="644" mass="70430" checksum="AC405CE34689845E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMQ9</accession>
    <name>Q2GMQ9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_10745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ82927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226012.1">
        <property type="nucleotide sequence ID" value="XM_001226011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMQ9"/>
    <dbReference type="STRING" id="306901.Q2GMQ9"/>
    <dbReference type="GeneID" id="4397214"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10745"/>
    <dbReference type="eggNOG" id="ENOG502R67I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051036_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GMQ9"/>
    <dbReference type="OMA" id="ENLTECA"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="124"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="396"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ82927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="535" mass="57943" checksum="8DA5E85F821308FF" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN39</accession>
    <name>Q2GN39_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228542.1">
        <property type="nucleotide sequence ID" value="XM_001228541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN39"/>
    <dbReference type="GeneID" id="4396206"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10615"/>
    <dbReference type="HOGENOM" id="CLU_1081832_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GN39"/>
    <dbReference type="OrthoDB" id="10377350at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="257" mass="28206" checksum="214ABCA7C6F7AE87" modified="2006-03-21" version="1">MTDAIPTTNNGAEHAMEQGGEYKRGATWIKRRGNLTARPTWKELFDYGSGCCKWVIANNNVDGECFTRATNNCYVATLCYHHWDANTDKKHWEIFHSTIPRTRFFDLLWDNGNKEAPIWHAATKKCRGVNRQVHAEDGVLYCFEREHKRCPGPGQERLRIVVQFRQQQQQQPRPGTAGSGKSGSTAYGSEVFDGSEVISARGMVEGAGPPNPKPQPPAGGSSPSSVAQLTRGMSALSVGRHGPVPPPGHPASRPSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNF8</accession>
    <name>Q2GNF8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228423.1">
        <property type="nucleotide sequence ID" value="XM_001228422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNF8"/>
    <dbReference type="STRING" id="306901.Q2GNF8"/>
    <dbReference type="GeneID" id="4396789"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10496"/>
    <dbReference type="HOGENOM" id="CLU_2372595_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNF8"/>
    <dbReference type="OrthoDB" id="4570525at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="95" mass="10777" checksum="1A0B473C026DD2DB" modified="2006-03-21" version="1">MSVVLDVTFQTHHGPPIHHVLKLYDRRFGSCLREVDGDRVAPHTQENEAAFEAFVRRGMMPGFLRHRHERNDPEESSSVGHQARDHHATGSSALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNM0</accession>
    <name>Q2GNM0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase</fullName>
            <ecNumber evidence="3 12">2.4.1.131</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_10434</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:29523"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="EC" id="2.4.1.131"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11 12">
            <dbReference type="Rhea" id="RHEA:29524"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.131" evidence="3 12"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228361.1">
        <property type="nucleotide sequence ID" value="XM_001228360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNM0"/>
    <dbReference type="FunCoup" id="Q2GNM0">
        <property type="interactions" value="375"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GNM0"/>
    <dbReference type="GeneID" id="4396930"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10434"/>
    <dbReference type="eggNOG" id="KOG1387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017896_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GNM0"/>
    <dbReference type="OMA" id="ARLYGWV"/>
    <dbReference type="OrthoDB" id="2276068at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03806">
        <property type="entry name" value="GT4_ALG11-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031814">
        <property type="entry name" value="ALG11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919:SF1">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15924">
        <property type="entry name" value="ALG11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="ALG11 mannosyltransferase N-terminal" evidence="15">
        <location>
            <begin position="128"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="14">
        <location>
            <begin position="384"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="82"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF15924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAQ84030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="562" mass="62262" checksum="6FD9931264D525A9" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNW4</accession>
    <name>Q2GNW4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_10340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>propanoyl-CoA + oxaloacetate + H2O = (2S,3S)-2-methylcitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58853"/>
            <dbReference type="EC" id="2.3.3.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228267.1">
        <property type="nucleotide sequence ID" value="XM_001228266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNW4"/>
    <dbReference type="FunCoup" id="Q2GNW4">
        <property type="interactions" value="863"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GNW4"/>
    <dbReference type="GeneID" id="4396505"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10340"/>
    <dbReference type="eggNOG" id="KOG2617">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022049_2_1_1"/>
    <dbReference type="InParanoid" id="Q2GNW4"/>
    <dbReference type="OMA" id="VLEWLFK"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050440">
        <property type="term" value="F:2-methylcitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06105">
        <property type="entry name" value="ScCit1-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010109">
        <property type="entry name" value="Citrate_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01793">
        <property type="entry name" value="cit_synth_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF8">
        <property type="entry name" value="CITRATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR610109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ83936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="472" mass="52508" checksum="A5FB133220A5DC01" modified="2006-03-21" version="1">MPPAMRLATSTMRASLKAPSVFYRNTAFTAARCYSSKSQTLKERFAELLPEKIEQIKALRKEHGSKVIDKVTLDQVYGGARGIKCLVWEGSVLDAEEGIRFRGKTIPECQELLPKAPGGNEPLPEGLFWLLLTGEVPTEQQVRELSADWAARSEIPKFVEELIDRCPTDLHPMAQFSMAVTALEQTSSFARAYAKGVHKRDYWGYTFEDSMDLIAKLPTIAARIYQNVFKGGKVVPAEKDKDYAYNFSNQLGFGNNTDFIELMRLYLTIHTDHEGGNVSAHTTHLVGSALSSPFLSLAAGLNGLAGPLHGLANQEVLNWLTEMKKVVGDDLSDEAITKYLWDTLNSGRVVPGYGHAVLRKTDPRYSAQRKFALEKMPSDPMFKLVSQVYKIAPKVLTEHGKTKNPYPNVDAHSGVLLQYYGLTEGNYYTVLFGVSRAIGVLPQLIIDRAVGAPIERPKSFSTDKWVEICKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GP21</accession>
    <name>Q2GP21_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228210.1">
        <property type="nucleotide sequence ID" value="XM_001228209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GP21"/>
    <dbReference type="GeneID" id="4396245"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10283"/>
    <dbReference type="HOGENOM" id="CLU_1651960_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GP21"/>
    <dbReference type="OrthoDB" id="4558298at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="160" mass="17328" checksum="A3EE796744B3A2FA" modified="2006-03-21" version="1">MSTSHAPRLPHSSPIPIFRKECRRYHLIEIWTPTVRRSFDPVSGTLKLAALGSTVVSFLSPGTGQSPKSCATHSHSVPSFYARVAQWSGCCWPLKSGAAPVPAATWADRRGSSSSHPFAGGRPSLPMSPHGKRLWSEAARRDETLEPVLWSQRIVCGGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GP50</accession>
    <name>Q2GP50_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_10254</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228181.1">
        <property type="nucleotide sequence ID" value="XM_001228180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GP50"/>
    <dbReference type="FunCoup" id="Q2GP50">
        <property type="interactions" value="567"/>
    </dbReference>
    <dbReference type="GeneID" id="4396084"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10254"/>
    <dbReference type="eggNOG" id="ENOG502R6NR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024934_7_1_1"/>
    <dbReference type="InParanoid" id="Q2GP50"/>
    <dbReference type="OMA" id="RNCKTRK"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF7">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ83850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="483" mass="53778" checksum="6FAE8AD2FB4E9924" modified="2006-03-21" version="1">MPEGLDTPAPAAAPGRPYHAKRPHRKSRMGCRNCKTRKVKCDESRPVCHPCTLRGEKCVYLLAPPPARSSRSRTASPASSSSGSRPAPTPPSTQTPASDPDLALLGRHTPAVTHQPQFIPSGHSEADMRLLWFYTTATYASFSTGQLKERSVDVILRVNVVQQAFANPFLMNCLLGLTAMHVNYLGIPHMGISRALEAHYRTQGLESYRKAIEAADPTTYPALLATSLFLCGLSTHVFRGEDARPFSLLDWMMLWKGIGAIIDVTNLPHMFRTGIAALLFRPAVDMDASARALPNYLLFMITSVKPDDADYPLVPKYYKALKFLGSLYLELRNGFSHRLFLRTVTFLTYLPKVILAAARERRPRALVILAHYMVFVTFKARACWWMDGIAGFEIPNIARFLGPAWAPLLRVPLAALEVGGDNRAIARLLLDDPEWDEPTDMGVEPASPEGERELAIRALMEEDVAPEVQAYRERKMQLQLRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPC9</accession>
    <name>Q2GPC9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228102.1">
        <property type="nucleotide sequence ID" value="XM_001228101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPC9"/>
    <dbReference type="STRING" id="306901.Q2GPC9"/>
    <dbReference type="GeneID" id="4396567"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10175"/>
    <dbReference type="eggNOG" id="ENOG502RJK3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015560_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPC9"/>
    <dbReference type="OMA" id="YPKRKRN"/>
    <dbReference type="OrthoDB" id="5235778at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="556"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="595"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="731" mass="79275" checksum="32008FE9676F5F03" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPF4</accession>
    <name>Q2GPF4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228077.1">
        <property type="nucleotide sequence ID" value="XM_001228076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPF4"/>
    <dbReference type="STRING" id="306901.Q2GPF4"/>
    <dbReference type="GeneID" id="4396871"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10150"/>
    <dbReference type="eggNOG" id="ENOG502RVYA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015087_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPF4"/>
    <dbReference type="OMA" id="ERWCDYW"/>
    <dbReference type="OrthoDB" id="5238236at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="2">
        <location>
            <begin position="41"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="900" mass="101989" checksum="57664C5F96F68A3F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPM2</accession>
    <name>Q2GPM2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228009.1">
        <property type="nucleotide sequence ID" value="XM_001228008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPM2"/>
    <dbReference type="GeneID" id="4396767"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10082"/>
    <dbReference type="HOGENOM" id="CLU_562562_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPM2"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="485" mass="52795" checksum="FE17FF325A6A8BF0" modified="2006-03-21" version="1">MRCLADVPDASFVSLREARQWDGCLRTRQLVVPEPARSSVVRVCVVYPSHKTSHPAIGTGQGSISNCHKLTTDGICLWKSMATGRFFSSSGGGDATELLGAQIATSAVTSFPVPTNARPEARHFHIQLYAKGRSDTAQNHNRFADFVTESLGHLGPSWAIETAEPPPASQRAHQGIFLTLQEFYHPRQGGSNQTNAAMRSRPAPADTTRSRGVWKDLENLAEAFINATSTPPSLRGQLRTISQTRCDLLESLTTLDAAFHEAKGWVQAWSGRGERRDTGQELTTEEILEFAQLIGSFSRSADDTAAALNVLAPLLDERYILPKAANTGMAVIGTVVAVAVTFFWWNPMGWTASALGTAASFVAAHGTASAVTCGAGGVTAVVCGVKGKIGHDQCKLMDKVRCAKVRYQNQKNEVLRTLVLILAREQFQYLGHEDQKNICDRMGIQISLLGERGYEHGVLKTVWEDLEDAYNMYYSSLRAAAVVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPP8</accession>
    <name>Q2GPP8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227983.1">
        <property type="nucleotide sequence ID" value="XM_001227982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPP8"/>
    <dbReference type="STRING" id="306901.Q2GPP8"/>
    <dbReference type="GeneID" id="4396037"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10056"/>
    <dbReference type="eggNOG" id="ENOG502RUKM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047725_3_3_1"/>
    <dbReference type="InParanoid" id="Q2GPP8"/>
    <dbReference type="OMA" id="YTSEAVC"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051961">
        <property type="entry name" value="Fungal_Metabolite_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563:SF2">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ83652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="27914" checksum="41553D1ECAD7FC70" modified="2006-03-21" version="1">MEFRMSDEGWKARYNGRMHAGLLFGRSATAREQWCLNPDLLRIVNHFLRTTNPPDVDSQSASERSTDAILSQAASITILEGGKAQPLHRDDAIWQKAHVSQEQRGYRLGSDLGIGMLVAAVDTTYANGATLVVPGSHLWGDARIAQEHEVAAAELSRGEALLFLTSTLHAGGANTTPDPRTMYAIFYCRSWVRPEANDFACYTREEVESWSREAQKLAGYVTDRMLGICDDGDALDALRRGATQRWQDWLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQB7</accession>
    <name>Q2GQB7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose N-acetyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_09837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227764.1">
        <property type="nucleotide sequence ID" value="XM_001227763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQB7"/>
    <dbReference type="FunCoup" id="Q2GQB7">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GQB7"/>
    <dbReference type="GeneID" id="4396936"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09837"/>
    <dbReference type="eggNOG" id="KOG1950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_669028_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQB7"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="45244" checksum="1E4EFAF62C6F07FE" modified="2006-03-21" version="1">MVGAVNAQLTSDSTAVKVTNILSSRKLRLLLPITLILSVFVVFGHRYDALPRIPATWSQGSDSKPVDDTESVVDWSQFAYTQYVTNSQYLCNSVMLLERLQNVGSRADRVIMYPSYMLDQNAASISPDGRLLIKARDEYGAKLVPIQVQSRRGGDTTWAESFTKLLAFNQTQYKRVLSLDSDSVVLQSMDELFLLPSCPIAMPRAYWLYPDTKILSSQLVLVEPSEREFSRVMAKVDVAGRDDYDMEIVNYLYGDTALVLPHRRISAGESEVWDPVAVFNEAKFLHFSDWPVPKAVVGDGEDAGEEAAGVSCAGRDGILRGEGFVEWVLRGLYGKAQGTFLASRVQPHAQVSSLARRGGHRMVAAVHPKGQFSNLGRLPSTRTQQQLSSDCGGTHEKNGKLGGTLMVTSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQD0</accession>
    <name>Q2GQD0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_09824</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227751.1">
        <property type="nucleotide sequence ID" value="XM_001227750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQD0"/>
    <dbReference type="GeneID" id="4396402"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09824"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_0_5_1"/>
    <dbReference type="InParanoid" id="Q2GQD0"/>
    <dbReference type="OMA" id="MTWIACA"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF134">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="597"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="620"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="131"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ83420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="660" mass="71550" checksum="B5EF501DE77F2E8B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQP0</accession>
    <name>Q2GQP0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_09714</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227641.1">
        <property type="nucleotide sequence ID" value="XM_001227640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQP0"/>
    <dbReference type="STRING" id="306901.Q2GQP0"/>
    <dbReference type="GeneID" id="4396634"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09714"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_360149_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQP0"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001856">
        <property type="entry name" value="RAS small monomeric GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="604"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="698"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="703"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ83310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="777" mass="86110" checksum="1357348C89CF1608" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQV9</accession>
    <name>Q2GQV9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_09645</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227572.1">
        <property type="nucleotide sequence ID" value="XM_001227571.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GQV9"/>
    <dbReference type="GeneID" id="4396071"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09645"/>
    <dbReference type="eggNOG" id="KOG2604">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_240381_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQV9"/>
    <dbReference type="OrthoDB" id="296793at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:Golgi transport complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:autophagy"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="term" value="P:intracellular protein transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="COG3_C"/>
    </dbReference>
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        <property type="entry name" value="COG3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007265">
        <property type="entry name" value="COG_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302:SF8">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COG3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COG3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 N-terminal" evidence="10">
        <location>
            <begin position="143"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 C-terminal" evidence="11">
        <location>
            <begin position="300"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1318"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1398"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1318"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1420"/>
            <end position="1445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00031339"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ83241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1717" mass="187974" checksum="BA54FBE7865178F5" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQY8</accession>
    <name>Q2GQY8_CHAGB</name>
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        <recommendedName>
            <fullName evidence="10">DNA primase</fullName>
            <ecNumber evidence="10">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
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        <name evidence="12" type="ORF">CHGG_09616</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="10"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001227542.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="4396395"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="Q2GQY8"/>
    <dbReference type="OMA" id="NVTRGFN"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Prim-pol domain"/>
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    </dbReference>
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    <keyword evidence="2 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
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    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3 10" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ83212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="501" mass="56674" checksum="056B7C8AB4DFFE7F" modified="2006-03-21" version="1">MPVPDPSSAELGTSLPSAAQMEEDFAMAAESSSEDEEDIVMAEAGEVQGVEEDTKAATEPPAAQTVEDESIGVEIKQETKPAIKQEGKPEVKLEDLFEGLDSDDDEFIAPPQGLIETNDTSSIELLRIYYQRFFPWRYMFQWLNHSPIPSNDFKHREFSLWLHNDAVMRYQSYKTSDMLRQDVLRLMPRRIEIGPVYTADPRDRKTFRNSTAFVPMAKELCFDIDLTDYDDIRTCCDKANICNKCWKFTTMAIKVLDTALRDDFGYNHILWVYSGRRGVHAWVCDKKARALNDHQRKALASYFEVVTGKEGGKKVNIRRPLHPHLSRSIDILKDHFQEDVLEVQDPWQTPEKADALLQQIPNLQLREALRKKWESSPGRPSVSKWADIDVLAQTDGVAGLDPKDLLDAKQDIVLEHTYPRLDIAVSQKLNHLLKSPFVIHPGTGRVCVPIDRNDLDGFDPLDVPTLQGLVGEVDAWTETEGAAAAMAAVEVSEGSHRLSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQZ6</accession>
    <name>Q2GQZ6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227535.1">
        <property type="nucleotide sequence ID" value="XM_001227534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQZ6"/>
    <dbReference type="GeneID" id="4396138"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09608"/>
    <dbReference type="HOGENOM" id="CLU_1695272_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQZ6"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="155" mass="16678" checksum="2903EA73F46D9A46" modified="2006-03-21" version="1">MPAKSNEIPHRRNGRSAEMRAKRSPGSGRLGETGALRQRTISATAMEVPPPTLSDLRDSPVKNGNKGLLTCPWAFGDGSQPRDANLAPQNQSGAYNLPLRNQLGTGNPKALSHQPPFIPKSSDNRVILRSLERRRPLGLTPPLVGLEVTECGTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GR08</accession>
    <name>Q2GR08_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_09596</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227523.1">
        <property type="nucleotide sequence ID" value="XM_001227522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GR08"/>
    <dbReference type="STRING" id="306901.Q2GR08"/>
    <dbReference type="GeneID" id="4396131"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09596"/>
    <dbReference type="eggNOG" id="ENOG502QU5N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021380_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GR08"/>
    <dbReference type="OMA" id="DMNMDFL"/>
    <dbReference type="OrthoDB" id="5333823at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="139"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="562"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="575"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="635"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ83192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="748" mass="82471" checksum="42D627580ABD8844" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GR41</accession>
    <name>Q2GR41_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_09563</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 77 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227490.1">
        <property type="nucleotide sequence ID" value="XM_001227489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GR41"/>
    <dbReference type="GeneID" id="4395030"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09563"/>
    <dbReference type="eggNOG" id="ENOG502S9ID">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039661_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GR41"/>
    <dbReference type="OMA" id="ANDWAHE"/>
    <dbReference type="OrthoDB" id="3763672at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF3">
        <property type="entry name" value="NUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="5">
        <location>
            <begin position="176"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ85549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="390" mass="44108" checksum="F918088A7212E700" modified="2006-03-21" version="1">MPLQNLPQAWRRLVFFAPAFVVTLVLAAGIYNGSIPKPSLPTVVFDDPSAGPFHQKCGDEPPTLDNLPDVIRALWAPLVVPITAPVFTTIDGEKKRLPPSAELIHTEPLGKRVCILDLDNREFADHGDVFSYRLPAWDNLRGPAAGFLSHYLYAMIHGYSYKFVRAPKYPDRAPHWSKVVFTKEMLKQYDVVVMMDADAMFSTPQVPLEWLLNYWKIGPEALVAMPEDPLDHPNYDVRQRVNVNSGFIIAQAGEKTQRLFKDWAECPSETRYPGCAVWKKRPFHEQSAFSSHVRYDFLDGYSIDSHPQYIRTIPCTEANGYPKVAGSGCVGQFVRHYWADKNLTNLEFNHNVMAALTPLLVQAAYKKPGIVEDYRGKVLDGAQILDKPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRS9</accession>
    <name>Q2GRS9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_09325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227252.1">
        <property type="nucleotide sequence ID" value="XM_001227251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRS9"/>
    <dbReference type="GeneID" id="4395663"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09325"/>
    <dbReference type="eggNOG" id="ENOG502RQ9S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_794545_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRS9"/>
    <dbReference type="OrthoDB" id="3473305at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF1">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="89"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ85311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="349" mass="40218" checksum="123C9D234A83AEB3" modified="2006-03-21" version="1">MVRSCDEVIAKKSLSPLAATAGEDDVRVHSEEVYSAILDVTAPTGYMDNQVPPTRATPRESRVKHNQPITHRAILPHCPHSPTMAEPKFHPFMRLPPELRHQIWEMSIEPREVVFGRLKETNDRRRKLPFCAAPPPSLLTACAESRAHMQRFYTKAYIRPLPGAPSHGRDNVPEYCWVNFATDTVRITHRQVPHFSHLAAARKLVVETLYELASRDRFRHPGLALEQLTILDLDESRGAIWWFPWIDFMEGLYYGCDAVAFDTTVLHGDAEPLTRENWLQVDRAWRKEMLDKIFWGHPELREQAERGGDDEDAEDVEHVEWPRLVTFRRRWRHVDGCACANKKGAPANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GS23</accession>
    <name>Q2GS23_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227158.1">
        <property type="nucleotide sequence ID" value="XM_001227157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GS23"/>
    <dbReference type="STRING" id="306901.Q2GS23"/>
    <dbReference type="GeneID" id="4395519"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09231"/>
    <dbReference type="eggNOG" id="KOG1911">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1447516_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GS23"/>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="187" mass="20728" checksum="A23DE8BE1D1E7CC9" modified="2006-03-21" version="1">MAGYLDRTITRRTLVLLAPEYYRRLKPKPSFVAMPPAFSDDEGSDVGVDQSLAKKSSRARNPAKYEDEVPEDDDAASMDEKNGAPEGDDEEGDDDDEELDEEVYVVENIMSHMIDKSIGGRDKLYEDSANALKTKKRGRPSSSTPQASGKRSRRTRDHPADGEPPLSAKAAHMETTSRELGRTHRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSA0</accession>
    <name>Q2GSA0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)</fullName>
            <ecNumber evidence="2">1.2.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_09154</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:13458"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="2"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227081.1">
        <property type="nucleotide sequence ID" value="XM_001227080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSA0"/>
    <dbReference type="STRING" id="306901.Q2GSA0"/>
    <dbReference type="GeneID" id="4395364"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09154"/>
    <dbReference type="eggNOG" id="KOG0525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012907_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GSA0"/>
    <dbReference type="OMA" id="SEAYYMA"/>
    <dbReference type="OrthoDB" id="878at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007584">
        <property type="term" value="P:response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="5">
        <location>
            <begin position="80"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ85140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="404" mass="43722" checksum="A2333919F97DC331" modified="2006-03-21" version="1">MKGSSLRALSRALARGSPLAPSAPALVASRRRYYSTHPPNAKLNLPTDYSTTPLLSHSSQSALANPELPPEVRNGTTKRMNLFQAVNDALSIALAEDESVMIFGEDVAFGGVFRCTGKLAETYGGDRVFNTPLTEQGIMGFAIGVAAEGMRPVAEIQFADYVYPAFDQLVNEAAKFRYRDGACGRSSGGLTVRMPCGGVGHGALYHSQSPESLFTHIPGLRVIMPRSPLQAKGLLLSAIRSNDPCVFMEPKILYRAAVEQVPTASYTLPLSKAEVLKEGSDVTIVSYGQPLYKCEAALKQAEKDLGISVELIDLRTIYPWDKETVFKSVRKTGRCLVVHEAMINAGVGAEVAAAVQEDPETFVRLEAPVARVAGFSIHTPLLYEALNAPDVARIYDNIKKVLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSM7</accession>
    <name>Q2GSM7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_09027</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226954.1">
        <property type="nucleotide sequence ID" value="XM_001226953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSM7"/>
    <dbReference type="GeneID" id="4394870"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09027"/>
    <dbReference type="eggNOG" id="ENOG502QPZ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039534_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GSM7"/>
    <dbReference type="OrthoDB" id="507128at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054539">
        <property type="entry name" value="Beta-prop_PDH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22807">
        <property type="entry name" value="TrAA12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208155" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller" evidence="3">
        <location>
            <begin position="58"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller" evidence="3">
        <location>
            <begin position="348"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ85013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="499" mass="53617" checksum="3B5FB9F919347F0A" modified="2006-03-21" version="1">MSSLVKRAAAAALLLSSSVVAQDTSIDVTTITSTVTTPTSSSQASACATALAPGYSAPVAAKGWKAQLIATNLTKPRSIKFDSNGGLLVLEAGVGLRHLTFDDNGGTCLSVKSSTSVIADEELNHGLELSEDGKTLYVSSAENVDRYEYDADSATVGSLTRIIANMTNPGVGHVSRTLLLSKHQPDLLLVSRGSAENLDLLAANQSTGISQIRAFNISNTTTTSLQRSLQLPRRRPPRRLGPTQLGRRGGAPSQGHHLVGREQRRRDPPPRSRHPRRKPRRGAQLPRPPQRHRLTEHPAGLQLRLPVLLRSQQHDRFPLPRQPNHRLTILPPKQRHRQRHRLRPAHRASRLTFQAHTALSTSNSCPATAHAPSSPSTAAGTATHPAGYKLSYAVFATDSSSSDTDSNSDLTPGFPAEASKSTHPIRDVLTAPDVSRCAEPGACFRPVGLAFDAAAQRLFCVERRDGGDLGGGARWGTRRGIVMGMVGVGPSPVHHRGWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSS1</accession>
    <name>Q2GSS1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA replication ATP-dependent helicase/nuclease</fullName>
            <ecNumber evidence="19">3.1.-.-</ecNumber>
            <ecNumber evidence="19">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CHGG_08983</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="19"/>
    <dbReference type="EC" id="3.6.4.12" evidence="19"/>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
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                <person name="Untereiner W.A."/>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="34" mass="3942" checksum="33811ADF86302F6B" modified="2006-03-21" version="1">MFQCYLCQMLRWNEASVLQDPCNPAVTPLGRSRI</sequence>
</entry>
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            <taxon>Pezizomycotina</taxon>
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
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    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
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            <end position="535"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ84814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1213" mass="136867" checksum="996A604C50B6FEC2" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTY5</accession>
    <name>Q2GTY5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_08569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226496.1">
        <property type="nucleotide sequence ID" value="XM_001226495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTY5"/>
    <dbReference type="GeneID" id="4395471"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08569"/>
    <dbReference type="HOGENOM" id="CLU_2527254_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTY5"/>
    <dbReference type="OrthoDB" id="10562375at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="84" mass="8648" checksum="E0FDF2BDA584518A" modified="2006-03-21" version="1">MFPSSTSGTAGTGGHCKVQGAEGIGRAAVHEYLNGPPSVADRLISGVPVADIAALVKAREAATQDMLAAWQGKWDKASRVDVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTZ8</accession>
    <name>Q2GTZ8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226483.1">
        <property type="nucleotide sequence ID" value="XM_001226482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTZ8"/>
    <dbReference type="STRING" id="306901.Q2GTZ8"/>
    <dbReference type="GeneID" id="4395261"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08556"/>
    <dbReference type="eggNOG" id="ENOG502S130">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_25_3_1"/>
    <dbReference type="InParanoid" id="Q2GTZ8"/>
    <dbReference type="OMA" id="YELNCEA"/>
    <dbReference type="OrthoDB" id="4584170at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="45279" checksum="37E5554E5004F0E8" modified="2006-03-21" version="1">MKFAPEKSELIHFNKGRRQWTEQVNLANPGGGTSPVKPEGSARFLGVWLDWKLNWKAHLVAVEKKLRTQSYALSRIVAKTWGMGLAKAREVYTKCIRSALAYGASSFHIPTDVGGEPAKKGITKALGKAQNKSLRIVAGAFKSTPIRNLETETWVPPLDLYLNKRLADFENRLQRPDLDDGRGGKKTAASVVLTACRKIQQRLSSRRGNRGRPRTLGPQGPTAVERAAGTVMRWTGGTVDTNRVVEEAWKARWLKERDGRAISRPADDFDHQRETLFRNETLRRHDGLNKAKSSLLIQIRTGAICLRDFLFTRGVPEVLTPACECGEGRETAEHLVVWCLAPPLARRWERTVIRTRRDFYSVLHGINPTTARLARRILDWLMDSGKLPMYSLARRLELETAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU89</accession>
    <name>Q2GU89_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226392.1">
        <property type="nucleotide sequence ID" value="XM_001226391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GU89"/>
    <dbReference type="FunCoup" id="Q2GU89">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="GeneID" id="4395493"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08465"/>
    <dbReference type="eggNOG" id="ENOG502S0SX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044999_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GU89"/>
    <dbReference type="OMA" id="WTEGEIS"/>
    <dbReference type="OrthoDB" id="2898509at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="36361" checksum="A026B6E85E5C5D7E" modified="2006-03-21" version="1">MVAYSEVEASNAQINDATAPRVSVFLGGTAGVGKFTITALVGTGASVKIYLVGRKSSAQRMQAFIQEMHAVNPKAQIIWTEGEISLLADVKRICNEIKSKERHIDLVFLTAGYAPYGERVETTEGIDISQSLEYYSRLLCVQHLLPLLNQAEAPRVVSVLSGGMSRGNIDTDDPDLRKPGSFGLMKGQMQLGTMNSLGLEKLADENPNVVFIHSSPGSVNTGNLGRTFDAKSGILAWVFETILGWFVRAFAMSDERSGQRNLFGATSAAFGGRGVPWKGEPAANSRGEPAAKRGLFHVSWNCNSTPNERVMTKLRGTAREKIWGHTQEILRPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUG5</accession>
    <name>Q2GUG5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226316.1">
        <property type="nucleotide sequence ID" value="XM_001226315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUG5"/>
    <dbReference type="GeneID" id="4394707"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08389"/>
    <dbReference type="HOGENOM" id="CLU_1916834_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUG5"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="132" mass="14663" checksum="64395D0B85F97A95" modified="2006-03-21" version="1">MAEETGGSSSSNTMIPHDPRQNGERLARRVTLLLTLPPLPADGRAGAQSQDLIDAIQSGVAVGRRERFQNAGVAERMDRLKGPMAVVAVGDVWEDWFRDRALLARQWDAPAHRFKFGGETMSQSYKLDWDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUM8</accession>
    <name>Q2GUM8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_08326</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ87073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225982.1">
        <property type="nucleotide sequence ID" value="XM_001225981.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4393898"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08326"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_242590_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUM8"/>
    <dbReference type="OrthoDB" id="4584170at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
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        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
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        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF177">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="547"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="156"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="11">
        <location>
            <begin position="1013"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="82"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="937"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1447"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="966"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1449"/>
            <end position="1458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ87073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1647" mass="180534" checksum="BD22D52445502B3B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV96</accession>
    <name>Q2GV96_CHAGB</name>
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        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_08108</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
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        <property type="protein sequence ID" value="EAQ86855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001225763.1"/>
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    <dbReference type="STRING" id="306901.Q2GV96"/>
    <dbReference type="GeneID" id="4394417"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08108"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_041217_21_1_1"/>
    <dbReference type="InParanoid" id="Q2GV96"/>
    <dbReference type="OMA" id="RTKRTCI"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Rho4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rho GTPase Rho4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
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        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
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        <property type="entry name" value="Small_GTPase_Rho"/>
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        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
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        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAS"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ86855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="257" mass="27737" checksum="E14333EA757C25D3" modified="2006-03-21" version="1">MTEGPAYSKKIVVVGDGGCGKTCLLISYSQGYFPEKYVPTVFENYITYPTHPPTGKTVELALWDTAGQEEYDRLRPLSYPETDLIFVCFAIDCPNSLENVMDKWYPEVLHFCPYTPLILVGLKSDLRHKKTCIDMLKTQGLTPVTADQGLAVAKKMGAQYMECSSKEMKGVEEIFERAILTVVANDRKVLEAEAAAAGPMSPTGSGIGIGRRGSTNLNGLSGGSKNGHGSSGGGITFGSDGVQIPVVKKKKRKCALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GW50</accession>
    <name>Q2GW50_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_07804</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225460.1">
        <property type="nucleotide sequence ID" value="XM_001225459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GW50"/>
    <dbReference type="FunCoup" id="Q2GW50">
        <property type="interactions" value="405"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GW50"/>
    <dbReference type="ESTHER" id="chagb-q2gw50">
        <property type="family name" value="ABHD11-Acetyl_transferase"/>
    </dbReference>
    <dbReference type="GeneID" id="4394450"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07804"/>
    <dbReference type="eggNOG" id="KOG2382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_53_0_1"/>
    <dbReference type="InParanoid" id="Q2GW50"/>
    <dbReference type="OMA" id="FLGMSDN"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000039">
        <property type="entry name" value="Esterase ybfF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="70"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ86551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="314" mass="34528" checksum="852F5062F724A3C8" modified="2006-03-21" version="1">MITLRPSTSAFRQAYSGCVSRVRVPVSASGPASGSFLAARVQASSPFSTVSLAYDLHEPAKPVADKQTSPIIFMHGLFGSKKNNRTVSRHVYAVDLRNHGDSPHDPRHDYPAMAADVADFIRQHGLKEPTLIGHSMGAKTAMTLALHSPDLVANLIAVDNAPVDARLGSDFGWYIQGMKKIDEAQVTRQAEADAILAPYEPSIAIRQFLLGNLHRPSPATSQTQQFRVPLSILARALDHLGDFPFKRPGEVRFEKPALFVRGTQSKYVPDEVIPLIGQFFPLFELVDVEAGHWVISEKPEAFKDAVVRFLEPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWB8</accession>
    <name>Q2GWB8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM5</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_07736</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225392.1">
        <property type="nucleotide sequence ID" value="XM_001225391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWB8"/>
    <dbReference type="FunCoup" id="Q2GWB8">
        <property type="interactions" value="888"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GWB8"/>
    <dbReference type="GeneID" id="4393384"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07736"/>
    <dbReference type="eggNOG" id="KOG0481">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_7_2_1"/>
    <dbReference type="InParanoid" id="Q2GWB8"/>
    <dbReference type="OMA" id="ITYCKTR"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030174">
        <property type="term" value="P:regulation of DNA-templated DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17756">
        <property type="entry name" value="MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000005">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000015">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000241">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008048">
        <property type="entry name" value="MCM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054125">
        <property type="entry name" value="MCM5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21933">
        <property type="entry name" value="MCM5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01661">
        <property type="entry name" value="MCMPROTEIN5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="317"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ86483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="718" mass="80066" checksum="56131D5CF7A62BD8" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWV4</accession>
    <name>Q2GWV4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_07550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225206.1">
        <property type="nucleotide sequence ID" value="XM_001225205.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4393271"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07550"/>
    <dbReference type="eggNOG" id="KOG1121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_244686_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWV4"/>
    <dbReference type="OrthoDB" id="4837779at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
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        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="195"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="669"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1136"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1104"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="682"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1157"/>
            <end position="1174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ86297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1591" mass="178421" checksum="91B0587F522F5014" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX23</accession>
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        <recommendedName>
            <fullName evidence="4">Conidiation protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="9041" checksum="3FE80E68DF24E39F" modified="2006-03-21" version="1">MDSAGAKSAMSNDMQELTQGKEDTGNQIRGHKANLSNPNTSEESKQTSKQALKELGGDDTLEDRRNNPVSKNASETLYGGRATAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXD8</accession>
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        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
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        <name evidence="3" type="ORF">CHGG_07366</name>
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    <organism evidence="3 4">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ86113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001225021.1"/>
    </dbReference>
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        <property type="interactions" value="67"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GXD8"/>
    <dbReference type="GeneID" id="4393551"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07366"/>
    <dbReference type="eggNOG" id="KOG0620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016428_1_3_1"/>
    <dbReference type="InParanoid" id="Q2GXD8"/>
    <dbReference type="OMA" id="NIDGCAM"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="19"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ86113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="346" mass="39383" checksum="091F6444F17B2F5E" modified="2006-03-21" version="1">MCRRPSSGSRSSPGNILCDKFATSTLYGYTPPPALHWVYRSERILQELHERDADILCLQEIATDVFRDFFSPELAQDGYKGVHWPRPKAKTMAEKDAQAVDGCAVFYKSSKWILLDKQLLDYANIAINRPDMKNQHDIFNRTAIMMENITRLAEKYSRWPALKDKKMIQLPLERRGSSAPTCPNPGRHKNTATTPTFHWSSAGDYNSTYDSSVYELLSMGRVAPNHSDFGDHQYGSFTRDGIEHPFSMRSAYVHLKGTPEDLPFTNYVPGFAEVIDYIWYSTNTLEVVSLLGPPDRDHLKRVPGFPNYHFPADHIQIMAELVIKARKDKKMVQEPDFGSGSGDRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXW2</accession>
    <name>Q2GXW2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">MPE1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_07192</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224848.1">
        <property type="nucleotide sequence ID" value="XM_001224847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXW2"/>
    <dbReference type="FunCoup" id="Q2GXW2">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GXW2"/>
    <dbReference type="GeneID" id="4394543"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07192"/>
    <dbReference type="eggNOG" id="KOG0314">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019105_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GXW2"/>
    <dbReference type="OMA" id="NVPDHEP"/>
    <dbReference type="OrthoDB" id="106784at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
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        <location>
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        </location>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="651" mass="70160" checksum="2376FB16E395EF41" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GY44</accession>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ85857.1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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        <location>
            <begin position="334"/>
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        </location>
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        <location>
            <begin position="456"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ85857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="475" mass="51293" checksum="885BCED814F6247C" modified="2006-03-21" version="1">MAVFVDLGEDDNESPQDGQPVWNGPIDALKPVPVSAAGLNLPGDGGIGAGNATWEEREKAHGLAARENPNQNSMTQALGCYPFSSAKGNFADSMTSIAMSIAASIDLNTLDNLSRTCRQIRQGLLQYRTMLLVSTMHCINAQAPVDPEDTFRYRARASNWYYMQDAGRSSYNGKSGRCARDMVAGCRRCGVVVCRNCAIKPPAPIVLRDRHRRLCGPCVAAPLGSLVKPRLGPEIRIDSDDMERAICGCGSGGVWLCQPCGRSIRGDDSEYRGIWRWRNQYTQIHGGLGTGIGEGDRGVICGRETECCAAREREQEMDGDAEDARDAEYFQLAAATPPSGGSSTGTPSLAPWTAAMSGAGSSSASLSSLVSSSGASVQDRRTPSPAIKPGYERHEVEGIGGVMKNMRVRMVKVGACVPEWDDERARGEILGREVQGKRRSWCGWCRRVIPSCKDYEMDRQADRKGKGKAKEGSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GY71</accession>
    <name>Q2GY71_CHAGB</name>
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        <recommendedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </recommendedName>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001224738.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="4393824"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07083"/>
    <dbReference type="eggNOG" id="KOG3872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4096268at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
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        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF37">
        <property type="entry name" value="LD47843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="634"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="45"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="595"/>
        </location>
    </feature>
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        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ85830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="660" mass="72424" checksum="862A88090CE3D0B6" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYL3</accession>
    <name>Q2GYL3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_06941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224597.1">
        <property type="nucleotide sequence ID" value="XM_001224596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYL3"/>
    <dbReference type="FunCoup" id="Q2GYL3">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="GeneID" id="4394206"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06941"/>
    <dbReference type="eggNOG" id="KOG4366">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040660_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GYL3"/>
    <dbReference type="OMA" id="NMHKSNA"/>
    <dbReference type="OrthoDB" id="265761at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ85688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31095" checksum="BBA61E10A8F48D13" modified="2006-03-21" version="1">MRVLPLLHLPRTPTGPRHSPQRALFQYSITTSRTSLLETDYNIHKSNSTYFADLDVSRSHLVTHLLGPGLPIIAANAKNKLVRDKQGVLVKGSLGVGLGAVFCSFRKEIAPLQGYEMWSRVLAWDRKWLYVVTHFVVKGKVRPNGGWNGKGKRTARQGGGANGQQQLPDDFAKYVIATAVSKYVFKLGRFTVHPALVIEAAKMLPERPGEGWTGGETGTGTPEDLGDLEELENAGAESEWDWKRIEAERRKGLRYADHFAALDGTNSLFDGGEDGAIGNFPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYT4</accession>
    <name>Q2GYT4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11 12">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4 11 12">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CHGG_06870</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11 12">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4 11 12"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224526.1">
        <property type="nucleotide sequence ID" value="XM_001224525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYT4"/>
    <dbReference type="SMR" id="Q2GYT4"/>
    <dbReference type="GeneID" id="4394095"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06870"/>
    <dbReference type="eggNOG" id="ENOG502RXA7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052631_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GYT4"/>
    <dbReference type="OrthoDB" id="2115822at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018208">
        <property type="entry name" value="GH11_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033119">
        <property type="entry name" value="GH11_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF3">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00776">
        <property type="entry name" value="GH11_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00777">
        <property type="entry name" value="GH11_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11 12" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208743" description="Endo-1,4-beta-xylanase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="16">
        <location>
            <begin position="107"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="15">
        <location>
            <begin position="248"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAQ85617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="284" mass="29255" checksum="672A3ED04CB61605" modified="2006-03-21" version="1">MVAISSLFLAAAAAVVAVAAPGELPGMHKRQTLTSSQTEIPTTATTSPSGLMVLATFGTPTRLVASTARPGLATATGGERDYQGFQDHQLQRLNTTPTATRTLPSTGGTRNPLIEYYVVENFGTYDPSTGAQRLGSVTTDGSTYNVYKTRRTNQPSIEGTSSFDQFWSVRVNKRSGGSVNMQAHFDAWAQSGLRLGTHDYQIVATEGYFSSGSSTVNVGGSTGGGNTGGGNTGGGNTGGGNTGGGGSNCSAKWGQCGGQGWQGPSCCQSGSTCQASNQWYSQCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZZ3</accession>
    <name>Q2GZZ3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_04903</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224117.1">
        <property type="nucleotide sequence ID" value="XM_001224116.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2GZZ3">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GZZ3"/>
    <dbReference type="GeneID" id="4392048"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04903"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000192_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZZ3"/>
    <dbReference type="OMA" id="RLAEWAN"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000010">
        <property type="entry name" value="Chitin synthase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF13">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="675"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="945"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1342"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1369"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1397"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="13">
        <location>
            <begin position="704"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1498"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1508"/>
            <end position="1517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ88284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1517" mass="169774" checksum="711B33742FF7F1F4" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H131</accession>
    <name>Q2H131_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Probable electron transfer flavoprotein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_04515</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </cofactor>
        <text evidence="7">Binds 1 AMP per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223729.1">
        <property type="nucleotide sequence ID" value="XM_001223728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H131"/>
    <dbReference type="FunCoup" id="Q2H131">
        <property type="interactions" value="446"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H131"/>
    <dbReference type="GeneID" id="4392990"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04515"/>
    <dbReference type="eggNOG" id="KOG3180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060196_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H131"/>
    <dbReference type="OMA" id="EINQPRI"/>
    <dbReference type="OrthoDB" id="276685at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000011">
        <property type="entry name" value="Electron transfer flavoprotein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000049">
        <property type="entry name" value="ET-Flavoprotein_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF8">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01065">
        <property type="entry name" value="ETF_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="8">
        <location>
            <begin position="26"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00070315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ87896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="258" mass="27759" checksum="0C0F657B3EAAC08C" modified="2006-03-21" version="1">MSALRILVPIKRVIDYAVKPRVNKAQTGVETAGVKHSMNPFDELSVEESVRIREKSRAPGGVEDICVLSAGPPKAQDILRTAMAMGADRAIHVDVKEGDDLEPLAVAKLLKGAVEQQKSNLVILGKQSIDDDANQTGQMLAGLLGWPQATQASKVEFGEGDAVNVTREVDGGVETVRAKLPMIITTDLRLNEPRYASLPNIMKAKKKPLEKKTLADFGVSAEKRLKVLKVTEPPARQGGGKVEDVDGLISKLKELGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1A1</accession>
    <name>Q2H1A1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223659.1">
        <property type="nucleotide sequence ID" value="XM_001223658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1A1"/>
    <dbReference type="STRING" id="306901.Q2H1A1"/>
    <dbReference type="GeneID" id="4391955"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04445"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_23_5_1"/>
    <dbReference type="InParanoid" id="Q2H1A1"/>
    <dbReference type="OMA" id="HCHRSSE"/>
    <dbReference type="OrthoDB" id="5059038at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="40821" checksum="F4D4DD9A966D8D67" modified="2006-03-21" version="1">MWTDIHTLPETNPLRNTTSRMRKFRRSYRSPFFQVADLLKDVPLDSLETIAPVVLAPWERRVRTTVDRTGIQQKETEWAVRIAVSSSARNNMVGIGGVVRLPLPMRDGSRNEAFSVTLGSRYRKIILATSNKAAVMALERPHQQSGQQYLCQAYDAISALRKAGNTISVVWIQAGTKNELLNTAKAKSREATRQDATPQTQDPAMRSTALRIAWAKRAPPTSLPDKVGRHSKRVDIALPGKHTQLLYDHLSRSEAGVLAQLRTGMAKLNTYLHRIKAAPSDQCTCGQARETVDHFLFRCKQWDQHRREMLQCTDVHRGNLSFYLGGKSPSDDKDWSPNMRAVSGDDTFCHCHRSSEDRTTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1W2</accession>
    <name>Q2H1W2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223448.1">
        <property type="nucleotide sequence ID" value="XM_001223447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1W2"/>
    <dbReference type="GeneID" id="4391968"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04234"/>
    <dbReference type="eggNOG" id="ENOG502R0P4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1266731_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H1W2"/>
    <dbReference type="OrthoDB" id="5138418at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="218" mass="23567" checksum="FED34D1EE929E48B" modified="2006-03-21" version="1">MSFPPQFHPPGAFHFDTSTTPGQPLHANVFRPPPSPTASSYNLAKSTGSLLSDISMPTAPHTGTAKRKRARTRESTPLDWHMNMEGAFDGREEEKGRESRRALGPKAIPEAESPSTQIPLDRTSNAPSSAAWSLFSLQTIEDMVGKVWEFCTKGAFRGFQAGGGQGYTVNGATVTETTGHSWGPESDTPIRLYEDTPMTQATPSYFLPASANALLARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2D5</accession>
    <name>Q2H2D5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223275.1">
        <property type="nucleotide sequence ID" value="XM_001223274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2D5"/>
    <dbReference type="GeneID" id="4392873"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04061"/>
    <dbReference type="eggNOG" id="ENOG502SQ23">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035264_2_1_1"/>
    <dbReference type="InParanoid" id="Q2H2D5"/>
    <dbReference type="OMA" id="HEHGLVW"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="137"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="370" mass="40927" checksum="1B43C8F6300A8D32" modified="2006-03-21" version="1">MASPGNDLSRFAGLRYLGHGFVKSAVFTFHFNGVHVQVVVASPEDEAGGDTLVPPSYNFLESVEGKFLSEMSELSWGEFDEERDKATERLEDQLEKLLQDACLQTMEQLAPSPVPANQTLHGYLYPQTYALQAFTDFETSRLVCRPGDGHPAMPERHPPVSEQQLSEMGLDLATTDIPIVEASQVILVRRLQRLVWKVTVNGEEMICKASSDVFCHAVPNELQAYLKIRSARAELNVPELKGLVVSHRGVIGILLGYIPHKHPSLAALLHMDSVATGSIPPDENTASLRRKWATQIEKTLRGLHDLGILWRDLKTDNVLINEDGDAVLLDFGGGNTHGWVDHDKYGTMEGEEQGLKKIMEELKVAGVEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2F4</accession>
    <name>Q2H2F4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_04042</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223256.1">
        <property type="nucleotide sequence ID" value="XM_001223255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2F4"/>
    <dbReference type="STRING" id="306901.Q2H2F4"/>
    <dbReference type="GeneID" id="4392780"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04042"/>
    <dbReference type="eggNOG" id="ENOG502SI68">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_3_5_1"/>
    <dbReference type="InParanoid" id="Q2H2F4"/>
    <dbReference type="OrthoDB" id="5022096at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF167">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="34"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="145"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="311"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ87423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="364" mass="38351" checksum="002F206D83833FBA" modified="2006-03-21" version="1">MSGAAVMPPDENRGPEILAVCGALVGLALVVVLLRVYVRARMVRHLGLDDYTIIAAMLVMFVEMMIIIPQVDLGGGRHVQYIKPEENVIKGLHLNFVTQPLCLIALCLTKVSVGFFLLRLTPSPRFRWVVIGTMIFTVLSASGNFSVAAILSLGIFAAVAAIVKITYLGAYGQHGDFLWDSADITIWTTIEINVAIIAASIPCLKPLFKTLLDGTSARYYGSSKYKRYAHHPDDDNITPQHHHPISSSKATKSTSTARSAGRASRRLSVAILGSRTAVGPEFEMYGSGGGANSSSAVGVGTTASASGKFSTEIKSTGSEESILPQAGDDDDRGWVDGGGSGAGAGAGAGGGGITERRLRSVVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2M8</accession>
    <name>Q2H2M8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THO complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_03968</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223182.1">
        <property type="nucleotide sequence ID" value="XM_001223181.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2H2M8">
        <property type="interactions" value="543"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H2M8"/>
    <dbReference type="GeneID" id="4392529"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03968"/>
    <dbReference type="eggNOG" id="KOG1874">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000511_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H2M8"/>
    <dbReference type="OMA" id="QERWTCI"/>
    <dbReference type="OrthoDB" id="29024at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021726">
        <property type="entry name" value="THO_THOC2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032302">
        <property type="entry name" value="THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11732">
        <property type="entry name" value="Thoc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16134">
        <property type="entry name" value="THOC2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="9">
        <location>
            <begin position="123"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="9">
        <location>
            <begin position="544"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 N-terminal" evidence="8">
        <location>
            <begin position="815"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="7">
        <location>
            <begin position="1162"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="620"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1080"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1112"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1510"/>
            <end position="2446"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1185"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1518"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1532"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1639"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1660"/>
            <end position="1794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1818"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1841"/>
            <end position="1872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1893"/>
            <end position="1925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="2053"/>
            <end position="2064"/>
        </location>
    </feature>
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        <location>
            <begin position="2111"/>
            <end position="2127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2191"/>
            <end position="2213"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2223"/>
            <end position="2252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2266"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2323"/>
            <end position="2334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="2337"/>
            <end position="2349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="2372"/>
            <end position="2382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2403"/>
            <end position="2423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ87349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="2446" mass="271104" checksum="EB3BB2B840A55F47" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3D8</accession>
    <name>Q2H3D8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_03708</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001222921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3D8"/>
    <dbReference type="GeneID" id="4392417"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03708"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="InParanoid" id="Q2H3D8"/>
    <dbReference type="OMA" id="GWLIMFQ"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF80">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12170)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208875" description="Major facilitator superfamily (MFS) profile domain-containing protein" evidence="9">
        <location>
            <begin position="22"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="9"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ87089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="492" mass="54319" checksum="1DE7799C071DD86C" modified="2006-03-21" version="1">MGKAFNVCLAAFAATGSFLFGYDSGVMTDVIASPDFLEFFDTDTGSPIIGAINSTFSGGAVFGSLMGGLTMDRFGRRKTIMIGAMIALIGAILQSAAQNLAMILVGRIVAGWAVGLLSMSVPVYQSECAHPKIRGLLVGISQQMIGVGFIVSTWVGYGSSYAHGELAQFQWRFPLAFQAAPALLLVCGIMFFPESPRHLMEIDCEEEAKRVLWKLHSDGTNDEWIQQEFHEIKTTIAAEKAITVPGWRIMFTVPQWRTRLMHGVAVQVFTQFTGINVIGYYQTQMYGALGITGNRALLVAGIYNCMGPLANLIFIVFMIDRVGRRRPLIWGTVAIAIALICESAVNSRIDRNNPDHGLSIAGVFFIFCVTVIFSWSWGPISWVYMSEVMPLSIRARGNAFATGIGNWLVSTFWSQLSPMALKALDWKFYFLFVAWDIVITIPIVFFFFKETKQLSLEEIDLLFGERSLGALPKDLDKGELAQPVKQEAENPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3R3</accession>
    <name>Q2H3R3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_06702</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222797.1">
        <property type="nucleotide sequence ID" value="XM_001222796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3R3"/>
    <dbReference type="STRING" id="306901.Q2H3R3"/>
    <dbReference type="GeneID" id="4390869"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06702"/>
    <dbReference type="eggNOG" id="ENOG502QRTW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031730_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H3R3"/>
    <dbReference type="OMA" id="YYSQCAP"/>
    <dbReference type="OrthoDB" id="3238762at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
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    </dbReference>
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            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="310" mass="31134" checksum="2FEE0E80801F1BBF" modified="2006-03-21" version="1">MRSTFAAALAALAAQEVAGHATFQQLWVDGTDYISLPCARAVSGKCPVKAGGTVTVEMHQQPGDRSCNNEAIGGAHYGPVQVYLTKVSDATTADGSTGWFKIFSNSWSKKSGGNSGDDDNWGTRDLSNCCGRMDVPIPKDLASGDYLLRAEALALHTAGQANGAQFYMSCYQISIEGGSGTASPATVKFPGAYSANDPGIKINIHSALSGYQAPGPAVYAGGTTKQAGSGCSGCEKTCKVGSSPTAVAPSSGGSTGGNSGGAAPGGGNACSVQAYGQCGGDGYSGCTECASGYTCKAVSPPYYSQCAPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3T0</accession>
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        <submittedName>
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        <name type="common">Soil fungus</name>
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        <lineage>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ90066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="251" mass="26996" checksum="5506D649704039B8" modified="2006-03-21" version="1">MADPWQDEAPQGRQEGYYPPLPGTGPRVTMPQQQPWEYTIPQGPRRNATTPAIYPRRETAAPIIFTAAPPNNITPCNPWQFGYRHQAGGPSQRTLIPSAPATGSFPPAQGAPGRDFPPVESTTAPTNTNTGRQATAGNAQPAEGTARGGGVTQGPRPPFRPSYMANPQSRAERENPTREVIARRMAAGVSANYRGKIRSSSHAGFAFSSKTIPATCKGPRVVPRRDRKDQGSVMRWKAKNMALDGGDRGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3U8</accession>
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        <submittedName>
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </feature>
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        </location>
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        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
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            <end position="56"/>
        </location>
    </feature>
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    </feature>
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    </feature>
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    </feature>
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        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="590" mass="66916" checksum="11050CA468091BEF" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4Y1</accession>
    <name>Q2H4Y1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chitin synthase activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_06284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222379.1">
        <property type="nucleotide sequence ID" value="XM_001222378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4Y1"/>
    <dbReference type="STRING" id="306901.Q2H4Y1"/>
    <dbReference type="GeneID" id="4391307"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06284"/>
    <dbReference type="eggNOG" id="KOG1550">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_126_0_1"/>
    <dbReference type="InParanoid" id="Q2H4Y1"/>
    <dbReference type="OMA" id="RLSIVWY"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF3">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="956"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="51"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
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        <location>
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            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="512"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="599"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="988" mass="105693" checksum="F3A8B2E986962393" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H509</accession>
    <name>Q2H509_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosducin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_06256</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222351.1">
        <property type="nucleotide sequence ID" value="XM_001222350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H509"/>
    <dbReference type="FunCoup" id="Q2H509">
        <property type="interactions" value="460"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H509"/>
    <dbReference type="GeneID" id="4390305"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06256"/>
    <dbReference type="eggNOG" id="KOG3170">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072604_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H509"/>
    <dbReference type="OMA" id="FCEIRAN"/>
    <dbReference type="OrthoDB" id="45518at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071444">
        <property type="term" value="P:cellular response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903333">
        <property type="term" value="P:negative regulation of protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02988">
        <property type="entry name" value="Phd_like_VIAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051498">
        <property type="entry name" value="Phosducin-like_chap/apop_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809:SF3">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="71"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ89637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="260" mass="29041" checksum="E3F231B2BFEB738A" modified="2006-03-21" version="1">MAAPTEQRIAVPIDDPNADTEWNDILRKHGVIPEKPPSPTPLIEEAILEARRIAHENRLEGKDLSDLSDLEDEEDEAFLETYRQKRMQELAALQKTSVHGSVYPLSKPDYEREVTEASQAGPVLVNLASPQGSNVESRVLSELWRQAAREYGDIKFCEMRADKAIEGYPERNCPTILVYSKGEIVKQVVTLATVGGVRMSMLDLDNILVEVGALKDDDIRVLKRRRAAEDAEEERAAGGSRGIKSSRDGMKPSDDDDDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5J4</accession>
    <name>Q2H5J4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidoligase enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_06071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222166.1">
        <property type="nucleotide sequence ID" value="XM_001222165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5J4"/>
    <dbReference type="GeneID" id="4391415"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06071"/>
    <dbReference type="eggNOG" id="ENOG502SUNA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_473261_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5J4"/>
    <dbReference type="OrthoDB" id="412402at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022025">
        <property type="entry name" value="Amidoligase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847:SF1">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12224">
        <property type="entry name" value="Amidoligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="64118" checksum="9E8AA86CC76997DA" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5P2</accession>
    <name>Q2H5P2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222118.1">
        <property type="nucleotide sequence ID" value="XM_001222117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5P2"/>
    <dbReference type="GeneID" id="4390463"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06023"/>
    <dbReference type="HOGENOM" id="CLU_640930_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5P2"/>
    <dbReference type="OrthoDB" id="4955450at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="428" mass="48317" checksum="3846FB6B089FD055" modified="2006-03-21" version="1">MATVNVDVKLTGPDNWKSWNERFRSEATTRDLWELIDPKGTSKGQFKTAPIKPAIKDYPKRLDRADAPPAQSTRAGSVSSSVTVGESQALAIGPPVEEIDRRNPPRNTSEMTALGRDAYRTDLSAYHFEWQLYEAERQNLNRLTAWIRQTVAPQLYDTTCKADKTIDLWYATLKERAGSDDREELQQSMKHPEHRESRTCTSSPAPRPRQHTPNRSRSRSPGARGVRNHGHKRKHTGGAKSGCLACDGLHPLSGCWALFPELRPSYYPPAYRREFLAKERLEKDPELRRQVEALQSIIEALASFLGMMELQFGIKIKAVEADNEIFTVKPCGLRSVISDSSPRRRYASSQWRRRALTGCGQGEDQRHEEQLEAPSVALAGNQQSASTLSALTSTINWKTPFEIFHSNPDERRKLISPTFAPMDVNHTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5W7</accession>
    <name>Q2H5W7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_05948</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="252"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ89329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="625" mass="69102" checksum="A811D33426280A8E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5Z2</accession>
    <name>Q2H5Z2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Endopolyphosphatase</fullName>
            <ecNumber evidence="3 12">3.6.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_05923</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[phosphate](n+1) + n H2O = (n+1) phosphate + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22452"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endopolyphosphatase PPN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.10" evidence="3 12"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001222017.1"/>
    </dbReference>
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        <property type="interactions" value="184"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H5Z2"/>
    <dbReference type="GeneID" id="4391431"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05923"/>
    <dbReference type="eggNOG" id="KOG3770">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013424_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H5Z2"/>
    <dbReference type="OMA" id="WAERYSV"/>
    <dbReference type="OrthoDB" id="348678at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000082">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012358">
        <property type="entry name" value="EndopolyPtase_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF55">
        <property type="entry name" value="ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027093">
        <property type="entry name" value="EndopolyPtase_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209299" description="Endopolyphosphatase" evidence="14">
        <location>
            <begin position="19"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="15">
        <location>
            <begin position="41"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="445"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="639"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="451"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="499"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="645"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="680"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR027093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAQ89304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="725" mass="81281" checksum="AC51BC808E39ECF4" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H682</accession>
    <name>Q2H682_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_05833</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221928.1">
        <property type="nucleotide sequence ID" value="XM_001221927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H682"/>
    <dbReference type="STRING" id="306901.Q2H682"/>
    <dbReference type="GeneID" id="4390028"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05833"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_172_1_1"/>
    <dbReference type="InParanoid" id="Q2H682"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="291"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="464"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="151"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="8">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ89214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="524" mass="58210" checksum="1D5C6D0991BF650D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6R8</accession>
    <name>Q2H6R8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221742.1">
        <property type="nucleotide sequence ID" value="XM_001221741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6R8"/>
    <dbReference type="GeneID" id="4390918"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05647"/>
    <dbReference type="HOGENOM" id="CLU_1106996_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6R8"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="251" mass="26206" checksum="3BCA8F36F302BBC5" modified="2006-03-21" version="1">MDTLGYDPSSPTVPNCSSSISGSQQEQLPIAGAGAPCGPPPPPATYATFAEADEGIKAHALSNGYSLTVKEIWPRGADATPVANAINMPKLYPVFDSTTLFYEWVFQGRILLCSWGTFFYQEGIFFAVREASSAVGGPSFAMGGSSDCCVLGVDAQPVRLALHAWPDGVPEVSILEPTPAPAPLLEPTPALTPGDGIDPLAFLMPDGHCGRGRVNGQEGKCPRSYPALTSLAAARHGSVVLMMLQNGAASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H716</accession>
    <name>Q2H716_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL13m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_05549</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221644.1">
        <property type="nucleotide sequence ID" value="XM_001221643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H716"/>
    <dbReference type="FunCoup" id="Q2H716">
        <property type="interactions" value="641"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H716"/>
    <dbReference type="GeneID" id="4390502"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05549"/>
    <dbReference type="eggNOG" id="KOG3203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082184_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H716"/>
    <dbReference type="OMA" id="HKPIYTP"/>
    <dbReference type="OrthoDB" id="274622at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000007">
        <property type="entry name" value="50S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ88930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="183" mass="20165" checksum="9AA1AEACFF62B226" modified="2006-03-21" version="1">MSQTVGATRLAYSRVWHHISASTPHPTLSTIKAPAEAVTPPSLGRLASRIATILMGKHKPIWDPSTDCGDYVVVTNCAALYTTGQKKYRKTYYRHNTRPGSLRTVTMDVLMDKFGGSEVLRKAVSGMLPKNRLRDKRLARLKAFEGDAHPYKENLVRFGGKVVGTSGWEDVVKAVRAADAARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H739</accession>
    <name>Q2H739_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc-regulated transporter 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_05526</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221621.1">
        <property type="nucleotide sequence ID" value="XM_001221620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H739"/>
    <dbReference type="FunCoup" id="Q2H739">
        <property type="interactions" value="395"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H739"/>
    <dbReference type="GeneID" id="4391370"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05526"/>
    <dbReference type="eggNOG" id="KOG1558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027089_0_2_1"/>
    <dbReference type="InParanoid" id="Q2H739"/>
    <dbReference type="OMA" id="HHHGHFN"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000007">
        <property type="term" value="F:low-affinity zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF69">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="166"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ88907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="42295" checksum="563DA035F7D2B612" modified="2006-03-21" version="1">MHRHIYRQILVSREDGDAAAAVPECEISPSSTDYWGLRIASIFVILIGSALGALLPVFLARTSRMQVPKLCFFIAKYFGTGVILATAWMHLLSPASDNLRDECLANILPDYDWAMAIGLMTVMVMFLLELIVSRFDFGFGSAHDHSNEKSLETKDQNQAVIRHSQDAEAIGSNKSADTSTVAGSTSGGGFFDKSRVPGLRNDISYPPGGEDHLGHQRDHVQGDEHANYAAQITAIFVLEFGVIFHSIFIGLTLAVTDNFIILFVVLIFHQTFEGLGLGARLGMATWPPGARRWTPYALGLLYAVSTPFAIGMGLIATKSLALEAATSRVVNGVFDAISGGILMYTALVELVAHEFMFNPEMRKAGLGMQLSAYMCVALGVGLMALLAKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7L4</accession>
    <name>Q2H7L4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_05351</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221446.1">
        <property type="nucleotide sequence ID" value="XM_001221445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7L4"/>
    <dbReference type="GeneID" id="4390485"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05351"/>
    <dbReference type="eggNOG" id="ENOG502S7YR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088618_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H7L4"/>
    <dbReference type="OMA" id="SFDIYLV"/>
    <dbReference type="OrthoDB" id="5316007at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052479">
        <property type="entry name" value="GPI-anchor_Adhesion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185">
        <property type="entry name" value="SERINE/THREONINE-RICH PROTEIN ADG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185:SF1">
        <property type="entry name" value="UPF0619 GPI-ANCHORED MEMBRANE PROTEIN C1322.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208899" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="22"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="163"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ88732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="226" mass="22726" checksum="C60FD02DBA96A2C5" modified="2006-03-21" version="1">MRAQFATLLALAAPLYAIKITSPSKNDVVDPSKGVTVKWSTVNTDPSKAHLVLVNMASGHTPFSKDLGEIDLSAGSFKVSEKDVPSDGGYQFNFESTETQNTGILAQSEQFEVKSSASDSDDDEKSSSSATTSASASTSATSASSSSSVTLTTTLKTLTQTFTSTGSDTTVTGTTVTTSTGTPAGNSATQTESATSTSDGAAAPTGMVVQGGSLLALVAGVAAVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7R1</accession>
    <name>Q2H7R1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221399.1">
        <property type="nucleotide sequence ID" value="XM_001221398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7R1"/>
    <dbReference type="GeneID" id="4391488"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05304"/>
    <dbReference type="HOGENOM" id="CLU_1758585_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7R1"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="148" mass="16287" checksum="15FD238BDD45F3E0" modified="2006-03-21" version="1">MHVHAHTYSHTAFNPKSNPPDKPGAERRGHLRSIDSAAGCSSRHGASMSTENEQDRNESVRRRSPRASRKVPGFALLGCHGDAKRSIAAMDCSPGPLRRVLFKSKGGEARLLLVALMVGQMVDRNFTSLQRVERSLEFRATQGSIEHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7W8</accession>
    <name>Q2H7W8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aminotransferase class I/classII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_03686</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230202.1">
        <property type="nucleotide sequence ID" value="XM_001230201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7W8"/>
    <dbReference type="STRING" id="306901.Q2H7W8"/>
    <dbReference type="GeneID" id="4389833"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03686"/>
    <dbReference type="eggNOG" id="KOG0634">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_6_1"/>
    <dbReference type="InParanoid" id="Q2H7W8"/>
    <dbReference type="OMA" id="HAKRDVF"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF19">
        <property type="entry name" value="KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ91751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="38680" checksum="D3B2BAA30339AAC1" modified="2006-03-21" version="1">MGSVAYEPEALAFDPSPLFSQRVQRWEPGASKPNPDTFPFSKISITVNGPEEKTLVLDGTALSEALQYGPPAGHPGLLKWFQGLQQAVHGISNSDSWTCCVGNGSQEIIHKAFQVFTDPGDSVMLETLALAKRFNFMIFEDDAYFFLNFEQDQSKRARSYLALEQEVNGETGRVMRFESLSKIVSSGMRLQPSSTTQVLALTLFRHWGYTGFVEHCAKAAEFYQRKRDAFAAAADRHLQGRATWEVPTAGMFFWLKLLLPSGTDSFEILSKKGIDNKILAIPGMAFLPNARKACQLRASYSLVSDSDMDEACRRIAKLVDDAWREEFANSAKHEAQAPVPTTTMKITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8E0</accession>
    <name>Q2H8E0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HAUS augmin-like complex subunit 3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001230029.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="4388641"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03514"/>
    <dbReference type="eggNOG" id="ENOG502SC1V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027731_0_0_1"/>
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    <dbReference type="OMA" id="QWCKAII"/>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="314"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="59168" checksum="718EFC95E185F7F1" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H913</accession>
    <name>Q2H913_CHAGB</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229807.1">
        <property type="nucleotide sequence ID" value="XM_001229806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H913"/>
    <dbReference type="GeneID" id="4388841"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03291"/>
    <dbReference type="HOGENOM" id="CLU_1651951_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H913"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="153" mass="16944" checksum="CDF3D181FE28B1E0" modified="2006-03-21" version="1">MYMQNRCSGKHPAWVRWCPEAVKARGAAREAYHFRPRTFELALQQQTQQQQERLPPRMRIVPFRGASTLEEADDGFQEAGKRKRPRGRPPGFLIAQEEAARSSRQGKLTFARKFDTDLTGDRGDGVGGLGVTTPEAADTLEADGQDVGMQGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H925</accession>
    <name>Q2H925_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_03279</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="EAQ91344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229795.1">
        <property type="nucleotide sequence ID" value="XM_001229794.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="Q2H925">
        <property type="interactions" value="599"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H925"/>
    <dbReference type="GeneID" id="4389319"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03279"/>
    <dbReference type="eggNOG" id="KOG2126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004298_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H925"/>
    <dbReference type="OMA" id="YPSFDIF"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="550"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="610"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="637"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="671"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="698"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="725"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="769"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="803"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="842"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="905"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="992"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1024"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1064"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="37"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ91344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1101" mass="119286" checksum="A130534A6B6F5BD0" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H929</accession>
    <name>Q2H929_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_03275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229791.1">
        <property type="nucleotide sequence ID" value="XM_001229790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H929"/>
    <dbReference type="STRING" id="306901.Q2H929"/>
    <dbReference type="GeneID" id="4389315"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03275"/>
    <dbReference type="eggNOG" id="KOG1121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009123_20_1_1"/>
    <dbReference type="InParanoid" id="Q2H929"/>
    <dbReference type="OMA" id="GITRICH"/>
    <dbReference type="OrthoDB" id="5087195at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ91340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="54490" checksum="7C0C53306D7EC48C" modified="2006-03-21" version="1">MATSDTSSTATSPTNAAVVTGPVVTTENSTFSRLGHALSLVQQIEALGEDPPASIVPEQWPVVTCKKGLKYVPENWLDKRQDRRSWVWKYGFCVALVVDPTVKMKAKSFHFVCKRCSATFNAQSTSAARSHLEEQHRIFDDKPHSNSNDPQATTSRKRAATNHSISEMLSRNKNKKSTAVVPRTQGERFRYLLVCWMATANIPFAAVENKYYRQILQLFNAPLTDALLPKGGDTTRSWLTSMYHDLLDSIKIKLKASPHQKHLSFDLWTSSHGLALLAVVVHYFESSGNYQTHLLTLSRITGTHAGENIAPGVLDVIKTFDLQPCLGYFQTDDADNNDTAMTKVLLHLNPTLSPAQAIALKCKVRLIKSLAPESLAHHNAAEEGRLLQEWRKSGPIGKLHFLVHHIRRSPQRRDLFSDIAKSKLTEEEQQEFGAILMDKDIAKLQLRSDNETRWHSVYHMIDRAIMLRDPLDYFVNIVTKKGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H975</accession>
    <name>Q2H975_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229745.1">
        <property type="nucleotide sequence ID" value="XM_001229744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H975"/>
    <dbReference type="STRING" id="306901.Q2H975"/>
    <dbReference type="GeneID" id="4388905"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03229"/>
    <dbReference type="eggNOG" id="ENOG502R8TH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_669024_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H975"/>
    <dbReference type="OMA" id="WDLEVRT"/>
    <dbReference type="OrthoDB" id="5379420at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="411" mass="46038" checksum="5CA593E961F0F91C" modified="2006-03-21" version="1">MFSLRSSVPARRVACAVLQPNVFVLTSQLSVSWHHGPPQQQQQQQQQQQPQQQRRQYAMRAPSVSRRKRFIPLALVDSLDSPDLPNFPFKDVPIPPIDLWRSFKDKRGLGEMTPETCLHAFKQYCLVAPNDPMSTEPALVLERDFNIDLYTLYYTSLPLINTLDQNLSKIGYRMLIMASNLGYAPSTLTVMGMVAQTGRQPNMAKSTAWRTFDTNFKRLVRTGNSPDIFTLQGLLAKLQGDADNYVMSCFDKAIQAARSIPRSIADQPAPKNQDTPAGRKPRWTYEAFCHLGRGRILLKLNRTREAIASFKIAALELDHPDGYAELAKLLAPDAPERETYLIMAAQAGNFEACRLLALLMADRAADPALPRDERVVASKMAHEWAAIEPDAEMREQVGLQVTEKLSAASLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H992</accession>
    <name>Q2H992_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_03212</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229728.1">
        <property type="nucleotide sequence ID" value="XM_001229727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H992"/>
    <dbReference type="STRING" id="306901.Q2H992"/>
    <dbReference type="GeneID" id="4389686"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03212"/>
    <dbReference type="eggNOG" id="KOG0304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027974_3_0_1"/>
    <dbReference type="InParanoid" id="Q2H992"/>
    <dbReference type="OMA" id="ACIPRTT"/>
    <dbReference type="OrthoDB" id="1164111at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="305"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="333"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="365"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAQ91277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="405" mass="42296" checksum="291A3793A5DA15BA" modified="2006-03-21" version="1">MPPLNRFPSGPNTISPYHQQFPSHAQHATSHPPPMGATAAYLNAQVGGNPFAGSSNLLGLAGGLNTGAGFSDTEFPGVVARPMGGFRGKSDYHYQCLRTNVDLLKVIQIGIALFNEDGEQPPARPNSTDSAELRKTGSQAPMPYAWQFNFKFSLKEDMYNQTSIESLQQAGIDFALLERDGIDPHEFASLIIPSGLVCFEDVRWISFHGGYDFGYLTKLLFCEPLPCDDAIEIMQKFEQKSGLEHIAETLKLKRVGSAHQAGSDSLLTGRVFFELRKRIFNGDISDDHLGKVWGLGIPDFSMGGGGGGGITAGPNPSNNPVESTPPGHNHHPNGGGGGSGGGLQNGGGTPSTPNTGSVALAGTPAASSHNTNGTANISNSGGMGPMTPGGGGGVFGAFAFAGNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H993</accession>
    <name>Q2H993_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229727.1">
        <property type="nucleotide sequence ID" value="XM_001229726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H993"/>
    <dbReference type="STRING" id="306901.Q2H993"/>
    <dbReference type="GeneID" id="4389685"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03211"/>
    <dbReference type="eggNOG" id="ENOG502SCZX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030582_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H993"/>
    <dbReference type="OMA" id="SDWFQGK"/>
    <dbReference type="OrthoDB" id="5377009at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="162"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
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        <location>
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            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="429" mass="44888" checksum="5DD04460B3479FFD" modified="2006-03-21" version="1">MPYTGDGRSKGGGGGGLASWLSGSAGAADALGLSHDPETRNSPGPGTSKDATTPNMTPTQPQQTRTGQSTAGSNVATPKSTTATTTAASRFMSALSSRFNPTTPTTSPLPSVATAHPQDEICTLNIEAALFPSSPSSPSGAARDAFSPSAFKNLHLNAVGLLNKMQTAYREQAATLRDLQAERSAQGDEVEEAVTRAEHLRIQLEGMARKAAEQEQAIGALEAELEGERKARARAEAALGWTARRAPSSVGEGASVVSEDLGVEEERRRQRRESRHRKSVADGLSGEEDTTTDDENDSAGSESVFSRSRSPALPLQSPLQQAHTVSSMSDAASIVGVADASGTPQVAKTPRSGSVNATPKQRPMSAFQKIFKGISREDAGCLNCKGQDASVAWDTVGLLRDENRHLKTRIGELEVAVEGALDMVNGIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HA27</accession>
    <name>Q2HA27_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar complex-associated protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_02927</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001229442.1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="306901.Q2HA27"/>
    <dbReference type="GeneID" id="4388413"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02927"/>
    <dbReference type="eggNOG" id="KOG2153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012441_3_0_1"/>
    <dbReference type="InParanoid" id="Q2HA27"/>
    <dbReference type="OMA" id="HYCPQVR"/>
    <dbReference type="OrthoDB" id="10263597at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
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    <dbReference type="InterPro" id="IPR011501">
        <property type="entry name" value="Noc3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028977">
        <property type="entry name" value="Nucleolar_complex_p3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nucleolar complex-associated protein 3 N-terminal" evidence="8">
        <location>
            <begin position="124"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="CCAAT-binding factor" evidence="7">
        <location>
            <begin position="481"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="336"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
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        <location>
            <begin position="759"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
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        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR028977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ90992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="811" mass="89902" checksum="6F5848B0D6E10B15" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAC3</accession>
    <name>Q2HAC3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Carbamoyl phosphate synthase arginine-specific large chain, mitochondrial</fullName>
            <ecNumber evidence="14">6.3.4.16</ecNumber>
            <ecNumber evidence="5">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Ammonium-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Arginine-specific carbamoyl phosphate synthetase, ammonia chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CHGG_02831</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CarB family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="14"/>
    <dbReference type="EC" id="6.3.5.5" evidence="5"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229347.1">
        <property type="nucleotide sequence ID" value="XM_001229346.1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="306901.Q2HAC3"/>
    <dbReference type="GeneID" id="4388855"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02831"/>
    <dbReference type="eggNOG" id="KOG0370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000513_1_3_1"/>
    <dbReference type="InParanoid" id="Q2HAC3"/>
    <dbReference type="OMA" id="FPFNKFP"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01423">
        <property type="entry name" value="MGS_CPS_I_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000015">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-grasp fold, B domain"/>
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    </dbReference>
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        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
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        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
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        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF53">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
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    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="22">
        <location>
            <begin position="219"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="22">
        <location>
            <begin position="756"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="23">
        <location>
            <begin position="1021"/>
            <end position="1170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00068891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EAQ90896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1170" mass="128694" checksum="1442B0A0D215E9AE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAE0</accession>
    <name>Q2HAE0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_02814</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001229329.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="4388896"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02814"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_424638_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HAE0"/>
    <dbReference type="OMA" id="ANHIMQY"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="540"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="356"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="553"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="377"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="553"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ90879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="590" mass="64473" checksum="182694327B049E57" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAE6</accession>
    <name>Q2HAE6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_02808</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229324.1">
        <property type="nucleotide sequence ID" value="XM_001229323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAE6"/>
    <dbReference type="FunCoup" id="Q2HAE6">
        <property type="interactions" value="1037"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HAE6"/>
    <dbReference type="GeneID" id="4389252"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02808"/>
    <dbReference type="eggNOG" id="KOG1694">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066767_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HAE6"/>
    <dbReference type="OMA" id="KWYNADD"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000014">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049633">
        <property type="entry name" value="Ribosomal_eL6_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01170">
        <property type="entry name" value="RIBOSOMAL_L6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ90873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="199" mass="22261" checksum="20C9B9EEC80AF5BC" modified="2006-03-21" version="1">MSAPTTKTFGKSTRSVPHPTERAQKWYPAEDEDKPRKVRKAIRAWAPRSSLQPGTVLILLAGRFRGKRVVLLKNLDQGVLLVTGPFKINGVPLRRVNSRYVIATSLKVDLAGIDEAKIEEIAKPKYFTAEKTKEKAGEEAFFKQGEKPQKKEVSSSRAADQKAVDKALLANIKKVDMLASYLATSFSLRKGDKPHEMKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAJ0</accession>
    <name>Q2HAJ0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nop domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_02764</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229280.1">
        <property type="nucleotide sequence ID" value="XM_001229279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAJ0"/>
    <dbReference type="FunCoup" id="Q2HAJ0">
        <property type="interactions" value="1040"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HAJ0"/>
    <dbReference type="GeneID" id="4388369"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02764"/>
    <dbReference type="eggNOG" id="KOG2574">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026337_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HAJ0"/>
    <dbReference type="OMA" id="IGNGPMD"/>
    <dbReference type="OrthoDB" id="4771285at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000002">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000003">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027105">
        <property type="entry name" value="Prp31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019175">
        <property type="entry name" value="Prp31_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09785">
        <property type="entry name" value="Prp31_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="272"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="392"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="576"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ90829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="606" mass="64458" checksum="C399C111F6CE86B6" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAK2</accession>
    <name>Q2HAK2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_02752</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229268.1">
        <property type="nucleotide sequence ID" value="XM_001229267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAK2"/>
    <dbReference type="STRING" id="306901.Q2HAK2"/>
    <dbReference type="GeneID" id="4389015"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02752"/>
    <dbReference type="eggNOG" id="KOG3030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021458_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HAK2"/>
    <dbReference type="OMA" id="WNAGWMG"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF154">
        <property type="entry name" value="PAP2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G09730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="148"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="422"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="454"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ90817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="469" mass="50674" checksum="54C42E6B8C734515" modified="2006-03-21" version="1">MPDDSIRPLIYARSFSPAPTFEALNPTSMDNLDLAGGNVRRKGTVSWVLALSYVFDWAVLAAFAAIGYVLGHITPNKRPFSLDDRNIAFPFTVNETVPVWLAVVIAIIAPIFLIIVICLIFVPGATVPVGTPKSLIWKRKLWELHTGLLGLALSVVAAWFITNGMKNLFGKPRPDLLDRCQPDLDNLSKYIIGGLKGLKTATTSGQLVSPDICKNPDKSTLDDGFRSYPSGHSSSSASGLIYFSLFIASKFAITIPFLAPAGFADASAFTAFPSRTRLPSIKVSGPDTYELSNRGPGAPTPSTLDSALGNKGITRHNQTVSAVRRQAAAPPIYLLCLAVLPFFASVFIAGSRWWDYRHHGFDIIFGYLIGAVSAIFAFRYYHLPISSGAGWAWGPRSHDKAFWAGVGSFSYATDHLRGQYRSGDEEEALTGGDGYGRGSGMSGNTEPPSSRKGPSPDDRDVSYVGEARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HB68</accession>
    <name>Q2HB68_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">40S ribosomal protein S29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_02536</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="476" last="476">
            <title>High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Ruppert T."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="35079002"/>
            <dbReference type="DOI" id="10.1038/s41467-022-27967-9"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS) IN COMPLEX WITH ZN(2+)</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2024" name="Nat. Commun." volume="15" first="716" last="716">
            <title>Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.</title>
            <authorList>
                <person name="Klein M.A."/>
                <person name="Wild K."/>
                <person name="Kisonaite M."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="38267453"/>
            <dbReference type="DOI" id="10.1038/s41467-024-44862-7"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS) IN COMPLEX WITH ZN(2+)</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229052.1">
        <property type="nucleotide sequence ID" value="XM_001229051.1"/>
    </dbReference>
    <dbReference type="PDB" id="7OLC">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="Sd=1-56"/>
    </dbReference>
    <dbReference type="PDB" id="7OLD">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="Sd=1-56"/>
    </dbReference>
    <dbReference type="PDB" id="8OO0">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="Sd=1-56"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HB68"/>
    <dbReference type="EMDB" id="EMD-17004"/>
    <dbReference type="FunCoup" id="Q2HB68">
        <property type="interactions" value="656"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HB68"/>
    <dbReference type="GeneID" id="4388456"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02536"/>
    <dbReference type="eggNOG" id="KOG3506">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177289_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HB68"/>
    <dbReference type="OMA" id="HCFREIA"/>
    <dbReference type="OrthoDB" id="10252683at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.830.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="entry name" value="30s Ribosomal Protein S14, Chain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_uS14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039744">
        <property type="entry name" value="RIbosomal_uS14_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_uS14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004424">
        <property type="entry name" value="PRK05766.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010:SF2">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8 9 10" id="KW-0002">3D-structure</keyword>
    <keyword evidence="8 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 8 9" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ90601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="7OLC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="7OLD"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="8OO0"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="56" mass="6491" checksum="C818AB688DCA37F1" modified="2006-03-21" version="1">MAHESVWNSRPRTYGKGSRACRVCTHQAGLIRKYGLNICRQCFREKAADIGFVKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDA3</accession>
    <name>Q2HDA3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221022.1">
        <property type="nucleotide sequence ID" value="XM_001221021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDA3"/>
    <dbReference type="STRING" id="306901.Q2HDA3"/>
    <dbReference type="GeneID" id="4386228"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01801"/>
    <dbReference type="eggNOG" id="ENOG502SNQ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_743940_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HDA3"/>
    <dbReference type="OrthoDB" id="3525185at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="372" mass="41774" checksum="D9CEF8CB3FE407C2" modified="2006-03-21" version="1">MVGVPRSKGCITCRKRRKGCNLERPTCGQCKRAGLICEGYSAERVFVVSTPRSRQAGYSASSTPSSVGFPWQRIIQRNQVSSNITNLRLLARPEDERRCINQFWEAYFPSGQPIPSSAARSYTCTWTETARNFDRGDDCLRYALWANCLLVTGKRHGSVWMLREGSRVYGEALANLRNLLTGTRGLGRGTLIATIKLLSMFEAFSTQENGSMADRVQNWQRHHAGELALIVTRTPAAHIEGEAHHIFSDERVEMRLVLGAPEWKSIPWQKVPKDFKDILVDVLVDMPQLVEEFDNMRLCNDAAKRTGLQVELEQKCWEHDQQLLAWLASSGQLLGQGQTSLHVQTRCTMLEISRHPSARSSNPKPGCSGNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDC3</accession>
    <name>Q2HDC3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_01781</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221002.1">
        <property type="nucleotide sequence ID" value="XM_001221001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDC3"/>
    <dbReference type="FunCoup" id="Q2HDC3">
        <property type="interactions" value="361"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HDC3"/>
    <dbReference type="GeneID" id="4386265"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01781"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_59_8_1"/>
    <dbReference type="InParanoid" id="Q2HDC3"/>
    <dbReference type="OMA" id="ACIKKAC"/>
    <dbReference type="OrthoDB" id="539158at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000692">
        <property type="entry name" value="Serine/threonine protein kinase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ93546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="551" mass="60160" checksum="AAC342F4F625F06C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDG1</accession>
    <name>Q2HDG1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220964.1">
        <property type="nucleotide sequence ID" value="XM_001220963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDG1"/>
    <dbReference type="STRING" id="306901.Q2HDG1"/>
    <dbReference type="GeneID" id="4386775"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01743"/>
    <dbReference type="eggNOG" id="ENOG502SBR1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_644052_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HDG1"/>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="46331" checksum="3057F1C44464D1C3" modified="2006-03-21" version="1">MPLSKDSQTKATAALKPCNGKGPVIDNIPISGSTEQNDNEAPVPPAIIAAEAIDNPKMLLQTPNEHQSETITKHITETASLAEHLTRLDLKDEDDVRDILNGIIQALAINEESECEKPDLLPNSGIISREARRASQEGSQDGGQRLWCAIQRRRSTEQTPLAATEAALFGALSEADSGVVCRADKKKHTKSSASETVAASSGTGTPPADAGPKQQEDQPEEHTAVPSSPTDNVGTAAAGFEEFFKIQRSDLGGLGAFAARNLVRGQTILVERPLLRTTHFRLLPDYHNLSDAAKKAYLSLHDGENGDQFSKVERIKVLNSVRSSPSRFVKTWSRRGAELFISYGGSPAELYSTYGFRCACGGCTPLTDEDIRRLKNRVFGTWDCDEKHPSVDTRGIFKAQAWLMRKSGTRSMTAVLHTHDDVCVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDP5</accession>
    <name>Q2HDP5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_01659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220880.1">
        <property type="nucleotide sequence ID" value="XM_001220879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDP5"/>
    <dbReference type="GeneID" id="4387800"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01659"/>
    <dbReference type="HOGENOM" id="CLU_2483152_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HDP5"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ93424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="87" mass="9482" checksum="467B85C3655B4C38" modified="2006-03-21" version="1">MAKIRTVSSRIRIFRKAPAWTDITGESRNKSQSNAALVCHRSQMLGGSPASSTTHLSISNPEKEGFWSVRPFSGEDSEFASHGTSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HE07</accession>
    <name>Q2HE07_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7727 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220768.1">
        <property type="nucleotide sequence ID" value="XM_001220767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HE07"/>
    <dbReference type="GeneID" id="4388000"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01547"/>
    <dbReference type="eggNOG" id="ENOG502S16N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132815_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HE07"/>
    <dbReference type="OMA" id="AYFWAYS"/>
    <dbReference type="OrthoDB" id="2110422at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056144">
        <property type="entry name" value="DUF7727"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40629">
        <property type="entry name" value="PRO41 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40629:SF1">
        <property type="entry name" value="PRO41 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24853">
        <property type="entry name" value="DUF7727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7727" evidence="2">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="143" mass="16085" checksum="D7E616BA5BD701C5" modified="2006-03-21" version="1">MGRLIKNHWARLIVLSAAMYQIAAAVEGYFWPKIFWDFVTKTLDPAVKPIPVLQTINLVFGIILLAWEWPLGFLAGSSFHRSLEARLAFLPLTALAAALMYQGTNAAIYQVIGLGVYFWAYSEGEMICAKPWTLPQRTPRGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEJ0</accession>
    <name>Q2HEJ0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_01364</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mS38 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220585.1">
        <property type="nucleotide sequence ID" value="XM_001220584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEJ0"/>
    <dbReference type="STRING" id="306901.Q2HEJ0"/>
    <dbReference type="GeneID" id="4387019"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01364"/>
    <dbReference type="eggNOG" id="ENOG502S2R6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035429_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HEJ0"/>
    <dbReference type="OMA" id="PSTHHMS"/>
    <dbReference type="OrthoDB" id="5364404at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="Ribosomal_mS38_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035">
        <property type="entry name" value="AURORA KINASE A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="COX24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein mS38 C-terminal" evidence="6">
        <location>
            <begin position="311"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ93129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="345" mass="38142" checksum="23704F475EDA1ECE" modified="2006-03-21" version="1">MLPSSVRRVVAATPQSPTVSSLSSSVPRAAASYSLSYRPTGFQQRRYSSSKPSSPDDGSKDFAARPVPASRSSKTEKSKGQAKAAAPQPPSVPSTRHIGDEGLALSTFFALHRPISVTQLMPKSVSDDAFARIFATRTRNNRVADVLSTLSQTVSDLEEPLSKLNVANGDKQRSQEAHDAEEGTAKLSLKHSDGSETNLHIQLNPMAGQYLPYAPPPAPEPLAETAIDAESANSAIAEELAEPQDAQTRVYKAMVTIEETVDADGQVKVVAHSPELVEEGATERPQSFLERMLWRQLRYDESRRHQGRTMQAISVRRQRKLRMKKKKYKKLMKKTRNLRRKLDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HES3</accession>
    <name>Q2HES3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-amino-3-carboxymuconate-6-semialdehyde decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Picolinate carboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_01281</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite metabolism; quinolate metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.45" evidence="4"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220502.1">
        <property type="nucleotide sequence ID" value="XM_001220501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HES3"/>
    <dbReference type="STRING" id="306901.Q2HES3"/>
    <dbReference type="GeneID" id="4387404"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01281"/>
    <dbReference type="eggNOG" id="KOG4245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_314729_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HES3"/>
    <dbReference type="OrthoDB" id="2832284at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001760">
        <property type="term" value="F:aminocarboxymuconate-semialdehyde decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF27">
        <property type="entry name" value="2-AMINO-3-CARBOXYMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="13">
        <location>
            <begin position="45"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6570" evidence="14">
        <location>
            <begin position="569"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="464"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ93046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="929" mass="103156" checksum="FD3CD886C49E3356" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEU3</accession>
    <name>Q2HEU3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_01261</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220482.1">
        <property type="nucleotide sequence ID" value="XM_001220481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEU3"/>
    <dbReference type="FunCoup" id="Q2HEU3">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="GeneID" id="4386403"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01261"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_8_4_1"/>
    <dbReference type="InParanoid" id="Q2HEU3"/>
    <dbReference type="OMA" id="PPQKWNM"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="500"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="99"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ93026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="571" mass="61401" checksum="86AD74376CFC2130" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEY7</accession>
    <name>Q2HEY7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF6314 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_01217</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220438.1">
        <property type="nucleotide sequence ID" value="XM_001220437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEY7"/>
    <dbReference type="GeneID" id="4387676"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01217"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023116_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HEY7"/>
    <dbReference type="OMA" id="GQFPMGD"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045632">
        <property type="entry name" value="DUF6314"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19834">
        <property type="entry name" value="DUF6314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6314" evidence="6">
        <location>
            <begin position="574"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ92982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="751" mass="81977" checksum="1F690F17A0307397" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFL9</accession>
    <name>Q2HFL9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">DNA repair protein REV1</fullName>
            <ecNumber evidence="16">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CHGG_00985</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Involved in mitochondrial DNA mutagenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 2 magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="16"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220206.1">
        <property type="nucleotide sequence ID" value="XM_001220205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFL9"/>
    <dbReference type="FunCoup" id="Q2HFL9">
        <property type="interactions" value="761"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HFL9"/>
    <dbReference type="GeneID" id="4386468"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00985"/>
    <dbReference type="eggNOG" id="KOG2093">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003901_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HFL9"/>
    <dbReference type="OMA" id="IKNGMWM"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17719">
        <property type="entry name" value="BRCT_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01701">
        <property type="entry name" value="PolY_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000001">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000040">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000011">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1630">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1280">
        <property type="entry name" value="DNA repair protein Rev1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012112">
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    <sequence length="1141" mass="125482" checksum="8DF3559D44A73237" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
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                <person name="Untereiner W.A."/>
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            <dbReference type="PubMed" id="25720678"/>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGL7</accession>
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        <recommendedName>
            <fullName evidence="4">Pali-domain-containing protein</fullName>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ92402.1"/>
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        <property type="nucleotide sequence ID" value="XM_001219857.1"/>
    </dbReference>
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        <property type="interactions" value="6"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00637"/>
    <dbReference type="eggNOG" id="ENOG502S0K3">
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    </dbReference>
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    <dbReference type="InParanoid" id="Q2HGL7"/>
    <dbReference type="OMA" id="FGTFGWC"/>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
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        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="24490" checksum="3D4923902F3197EF" modified="2006-03-21" version="1">MARSTGFFHHIGTFLLFAATILLIVTCISAPVVHNLSLLRVDLGGDNGRGETVTFGTFGFCQTRPEADDSCSQSQVGYSPAAVMTQADGTEFSEYAERTTRALTKAMILHPIACGLNFIAFLLALGAGMIGSFLASMVALLAFLTTAVACIIDFVLFSIVKSNVNDRGGATGTGAYYGAAAWTILVSAICSLIGAVVVFFTCCSARLHRRRGVAHKTEYASPPRRRRFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGL8</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">CHGG_00636</name>
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        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001219856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGL8"/>
    <dbReference type="STRING" id="306901.Q2HGL8"/>
    <dbReference type="GeneID" id="4387190"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00636"/>
    <dbReference type="eggNOG" id="ENOG502S05V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_274400_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGL8"/>
    <dbReference type="OMA" id="PPRTNHH"/>
    <dbReference type="OrthoDB" id="3254104at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="830"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="891"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="924"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="957"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="857"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="641"/>
            <end position="651"/>
        </location>
    </feature>
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        <location>
            <begin position="665"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="703"/>
        </location>
    </feature>
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        <location>
            <begin position="717"/>
            <end position="730"/>
        </location>
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        <location>
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            <end position="764"/>
        </location>
    </feature>
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        <location>
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            <end position="778"/>
        </location>
    </feature>
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        <location>
            <begin position="869"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1071"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ92401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1168" mass="123143" checksum="4742FF45A893FE28" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH83</accession>
    <name>Q2HH83_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_00421</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="FunCoup" id="Q2HH83">
        <property type="interactions" value="313"/>
    </dbReference>
    <dbReference type="GeneID" id="4387183"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00421"/>
    <dbReference type="eggNOG" id="KOG1546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029389_3_1_1"/>
    <dbReference type="InParanoid" id="Q2HH83"/>
    <dbReference type="OMA" id="MHRIMVT"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="6">
        <location>
            <begin position="43"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ92186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="343" mass="38148" checksum="E8CE4ABC439DF9B4" modified="2006-03-21" version="1">MPTVNSNSYVHGNHSAPPPPPTTQQHYGYQQQFAFQYSQCTGRRKALLIGINYFNQRGQLRGCINDVRNMSAYLVENFGYKREDMVILTDDQQNPMSQPTKQNILRAMHWLVKDARPNDSLFFHYSGHGGQTKDLDGDEEDGYDEVIYPVDFRQYGHITDDEMHRIMVRPLQAGVRLTAIFDSCHSGTALDLPYIYSTQGILKEPNLAKEAGQGLLSAVSAYSRGDLGGVANNIMGFFKKASNSEDAYARSMAVKTSPADVVMFSGSKDDQTSADATIASQATGAMSWAFITALKKNPQQSYVQLLNSIRDELQTRYTQKPQLSCSHPLGRFLPALHPTASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHC2</accession>
    <name>Q2HHC2_CHAGB</name>
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        <recommendedName>
            <fullName evidence="4">NYN domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">CHGG_00382</name>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219603.1">
        <property type="nucleotide sequence ID" value="XM_001219602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHC2"/>
    <dbReference type="STRING" id="306901.Q2HHC2"/>
    <dbReference type="GeneID" id="4387948"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00382"/>
    <dbReference type="eggNOG" id="ENOG502S3QT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_356441_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHC2"/>
    <dbReference type="OMA" id="FRICEQP"/>
    <dbReference type="OrthoDB" id="5590473at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18724">
        <property type="entry name" value="PIN_LabA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF5">
        <property type="entry name" value="NYN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="728" mass="80401" checksum="226397179B688F0F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHU8</accession>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="4387739"/>
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    <dbReference type="eggNOG" id="ENOG502S7C8">
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    </dbReference>
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    <dbReference type="OrthoDB" id="4714109at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
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        <location>
            <begin position="133"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
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        <location>
            <begin position="290"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ91971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="432" mass="48928" checksum="A9F2B2DBB633FA78" modified="2006-03-21" version="1">MQKLSPDQEKHLADWVLAQEAFGLPVKHRQIQTFANRILHASGSDQTVGKHWLQKFINRYPVLKTKRNKSMDIKRLSGASIDVIKAWFRLLAIPIIKSVDPRDRWNMDETGIMEATSLTTSCGRVICHGYGRVPRPDEGTRGKRSQPIIKNGSQTNQQRNEGNGYRSQDPVWNERNDHRSSRSQQKGPEVGSSHYINNIYLLFLPAHASHVLQPLDLSVFSPLKTAYRCGIDDLALMTDSAPIGKRLFLCCYSKARSDAITERNIRSGWKASGLWPVNVDKPLMSRLLLPTQPTQPTQPAQPNQPTQPTQPTQPTQPTQPTQASSQGVNKPSSQEVKTPSRSQEVHKLVATNYRLKRLKAIDPVARTLFAKVGKSLDYTAIQLASQQQRIRALEAEVDRLKPRKKKKVRLDPNTRFAQIEQIMQAKRHLQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HID4</accession>
    <name>Q2HID4_CHAGB</name>
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        <recommendedName>
            <fullName evidence="3">MHYT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_00020</name>
    </gene>
    <organism evidence="4 5">
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219241.1">
        <property type="nucleotide sequence ID" value="XM_001219240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HID4"/>
    <dbReference type="STRING" id="306901.Q2HID4"/>
    <dbReference type="GeneID" id="4387587"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00020"/>
    <dbReference type="eggNOG" id="ENOG502R57D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008375_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HID4"/>
    <dbReference type="OMA" id="HQEFGHI"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152:SF1">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50924">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="3">
        <location>
            <begin position="21"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ91785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="891" mass="97285" checksum="96604AEE715B7953" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HIE0</accession>
    <name>Q2HIE0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_00014</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001219234.1"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00014"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_3_1"/>
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    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ91779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="54667" checksum="D76D673A7A45F766" modified="2006-03-21" version="1">MLTIVGGVAVLAVVTAVYLVLTVGKRNPKLPPGPPTWPIIGNLHQTPTKRTHLQFAKWAKQYGGIYSLKFGPGTSIVISSPRLIKQLFFREDMVMKHHIEVVDAEAVQMLRDFVVQPEGCMRHPKRFSNSIIMSLIYGTRTPTIKTKHMVKLYALMENWSKVMEAGNTPPVDIFPFLKLVPERFLGMWRSRAQDVGREMNALYSEWLEYVVRRRQDSGSRDCFLDRVLDQGEKVGLDKHGIYFLCGTVMEGGSDTTSSLIIAFLHAMTKWPAVLRKAQAEMDAVVGEERTPTWADHARLPYVAACVKEAHRWRPVTPLAFPHSLTEDDWVDGMFLPRGSDIFINAFGMHHDEARFPDPDTFDPAHYEGFTGLGSELANGDYANRDHYDYGSGRRLCPGIHLAEQNLFLTLAKLVWAFDIGPGKDAAGEVIEPDVSNEKGYCSGFLVCAEDFPCTITVRSEPRKATILRESDKATAEVFSRYETPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM14</accession>
    <name>Q2GM14_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_10990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226257.1">
        <property type="nucleotide sequence ID" value="XM_001226256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GM14"/>
    <dbReference type="STRING" id="306901.Q2GM14"/>
    <dbReference type="GeneID" id="4397223"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10990"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_23_6_1"/>
    <dbReference type="InParanoid" id="Q2GM14"/>
    <dbReference type="OrthoDB" id="414730at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="4">
        <location>
            <begin position="105"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="314"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="326"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ83172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="687" mass="75723" checksum="BB0885B6E29C922B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM35</accession>
    <name>Q2GM35_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Beta-xylanase</fullName>
            <ecNumber evidence="11">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_10969</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="11"/>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226236.1">
        <property type="nucleotide sequence ID" value="XM_001226235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GM35"/>
    <dbReference type="GeneID" id="4397236"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10969"/>
    <dbReference type="eggNOG" id="ENOG502SHCI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020161_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GM35"/>
    <dbReference type="OMA" id="MELRCHT"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF35">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208260" description="Beta-xylanase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="13">
        <location>
            <begin position="35"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ83151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="344" mass="37755" checksum="2B7A0226D301BA64" modified="2006-03-21" version="1">MKFSVSVALALGGFAAANPLPLNHQAEELFHRQVQTLNAAMVAAGREYIGTSLTVRNDNQESNIIRSEFGSITPENAQKWDATEPNRGQFNFGAADQHMNWAQQNGKHVRCHTLVWYSQLPGWVSNSGFNNATLIQVMTNHINQVMGRYKGRCNHWDVVNEALSEDGTYRDNVFLRVIGEAYIPIAFRAAAAADPAAKLYYNDYILATVCASTASAYQGHLTTESTPTQSTPTPSEEDLTAALKVTADLGVEVAWTEIDIRMRTPSNSQKLQQLADAYGRVARACLNVPSCVGMTIWGVTDRYSWVPNTFQGEGDALLWNSNYQKKAAYTSFLEGITSGGSSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM38</accession>
    <name>Q2GM38_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription activator GCR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_10966</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226233.1">
        <property type="nucleotide sequence ID" value="XM_001226232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GM38"/>
    <dbReference type="STRING" id="306901.Q2GM38"/>
    <dbReference type="GeneID" id="4397112"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10966"/>
    <dbReference type="eggNOG" id="ENOG502SBAB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009209_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GM38"/>
    <dbReference type="OMA" id="GTSTECH"/>
    <dbReference type="OrthoDB" id="4916058at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060963">
        <property type="term" value="P:positive regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.20">
        <property type="entry name" value="Centromere DNA-binding protein complex CBF3 subunit, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052146">
        <property type="entry name" value="HOT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038279">
        <property type="entry name" value="Ndc10_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031872">
        <property type="entry name" value="NDC10_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022210">
        <property type="entry name" value="TF_GCR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37784:SF2">
        <property type="entry name" value="HIGH-OSMOLARITY-INDUCED TRANSCRIPTION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37784">
        <property type="entry name" value="PROTEIN MSN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12550">
        <property type="entry name" value="GCR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16787">
        <property type="entry name" value="NDC10_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ndc10" evidence="3">
        <location>
            <begin position="96"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription activator GCR1-like" evidence="2">
        <location>
            <begin position="577"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ83148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="685" mass="77893" checksum="51D974E54AEC55DA" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM63</accession>
    <name>Q2GM63_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226208.1">
        <property type="nucleotide sequence ID" value="XM_001226207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GM63"/>
    <dbReference type="GeneID" id="4397086"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10941"/>
    <dbReference type="HOGENOM" id="CLU_420909_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GM63"/>
    <dbReference type="OrthoDB" id="10437651at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="529"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="471"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="566"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="604"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="627"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="651" mass="71650" checksum="71BE68F2A9CEBE5B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM66</accession>
    <name>Q2GM66_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Prenyltransferase alpha-alpha toroid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_10938</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226205.1">
        <property type="nucleotide sequence ID" value="XM_001226204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GM66"/>
    <dbReference type="STRING" id="306901.Q2GM66"/>
    <dbReference type="GeneID" id="4397164"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10938"/>
    <dbReference type="eggNOG" id="KOG0367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028946_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GM66"/>
    <dbReference type="OMA" id="PRSANHH"/>
    <dbReference type="OrthoDB" id="24893at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF4">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-1 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="9">
        <location>
            <begin position="18"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="93"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="314"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ83120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="373" mass="41173" checksum="156342DD41C02D16" modified="2006-03-21" version="1">MGDTPDHANGDTATEPTLDIDRHLKYWKMCLQAPLPNHYLSNEGVRMTLAYFIVNSIRILTPTPSPTSTTPPKPPLIPPSDHRRLRQWVLSHQQPGGGFAPSSTLLSPPTTTTTNNSNHTNPDPANPSATTGLANLPATLFALQLLALLADEGEEERAFEGVDRVQTLRWLRRLQRADGSFGEAVSWMPGEEEWFVGGGYDMLYCYIAVAVRWMLRGDVGGGGEDEAGVGDLDVGALERYILGSQTYDGGFAGSSKEEPHAGYAYCAIAALSLLDRPLTNSTALHPNKILHSGIRNMPALLHWLASRQFVYLEAPPPNPDDDNFDDSEDEDNFRLPVPPRRPLPRSANHHPRRVQRPLQQVLWRLPVRDGQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMA3</accession>
    <name>Q2GMA3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tautomerase cis-CaaD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226168.1">
        <property type="nucleotide sequence ID" value="XM_001226167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMA3"/>
    <dbReference type="GeneID" id="4397320"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10901"/>
    <dbReference type="eggNOG" id="ENOG502SN9D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113367_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GMA3"/>
    <dbReference type="OMA" id="MPLWLIY"/>
    <dbReference type="OrthoDB" id="2129288at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028116">
        <property type="entry name" value="Cis-CaaD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14832">
        <property type="entry name" value="Tautomerase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tautomerase cis-CaaD-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="128" mass="14397" checksum="84CDEB444FB7FB3C" modified="2006-03-21" version="1">MPLWLIYHPPSTFTTPSSKQSLAADITSIYTRSGLPAFYVVVNFIAVPATDTFVGGQNPNPDRPFVRFVADHIAVHIENDAARMQRMREMVNAALQPHVKEKGYDWEVHIDETPRGLWVINGLVPPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMD7</accession>
    <name>Q2GMD7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_10867</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226134.1">
        <property type="nucleotide sequence ID" value="XM_001226133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMD7"/>
    <dbReference type="GeneID" id="4397155"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10867"/>
    <dbReference type="eggNOG" id="KOG1153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_1_4_1"/>
    <dbReference type="InParanoid" id="Q2GMD7"/>
    <dbReference type="OMA" id="AQEVEYI"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208381" description="Peptidase S8/S53 domain-containing protein" evidence="8">
        <location>
            <begin position="21"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="167"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ83049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="424" mass="43655" checksum="95F916A1CE776DF6" modified="2006-03-21" version="1">MAGRVLLCFTLALSALGVSGVPTSLPNKTEGEFLGIPISNPGVLNAIPNRYIVVYNNTFNDDDIDVHEKSVIQTIAKRNVAKRSLTGKLLSTTVDTYKIGKWRAMALDADDLMINEIFSAKEVSYIEQDAVININARAVQGRTTTGLARISHAQAGSRTYVFDDSAGEGITAFVVDTGIRVTHSEFEGRATFAANFIDDVDTDEQGHGSHVAGTIGGKTFGVAKKVNLVAVKVLGADGSGSNSGVLAGMQFVVNNATAQGLGGKSVMNMSLGGGASAAINAAINNIEAAGVVPVVAAGNEAQDTANTSPGSAEAAITVGAIDQTTDRIAEFSNFGRLVDVFAPGVQVLSVGIETDNSTKALSGTSMASPHVAGLAAYLMALEGITGVQEVGDRIKELAQGTGARVRGSPRGTTTLIANNGADQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMN6</accession>
    <name>Q2GMN6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ82950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226035.1">
        <property type="nucleotide sequence ID" value="XM_001226034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMN6"/>
    <dbReference type="GeneID" id="4397350"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10768"/>
    <dbReference type="eggNOG" id="ENOG502SYM4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021744_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GMN6"/>
    <dbReference type="OMA" id="CRTIYLE"/>
    <dbReference type="OrthoDB" id="4570539at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF6">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ82950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="618" mass="70083" checksum="4A08597EA6AB629B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN72</accession>
    <name>Q2GN72_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228509.1">
        <property type="nucleotide sequence ID" value="XM_001228508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN72"/>
    <dbReference type="GeneID" id="4396720"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10582"/>
    <dbReference type="HOGENOM" id="CLU_1475010_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GN72"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="183" mass="19994" checksum="D2C7D86BBF084A42" modified="2006-03-21" version="1">MDIRALVNNNKSIHTSPCAQRFYQLLLRGLGRLCLLIIFDGWPTGCLVAYDRCTNTSRVALQGAPDSGKTLHVGRLPDSDRPQSLASHLTHVQETDNARGEEQWKACIKLIGICLRQPPGHQRTSPDGDSLYSMFSPPPTAPRRLGGRSDIPTSATFNKQIAAIQKDATNKAASEKTQSSGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNK3</accession>
    <name>Q2GNK3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228378.1">
        <property type="nucleotide sequence ID" value="XM_001228377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNK3"/>
    <dbReference type="GeneID" id="4396801"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10451"/>
    <dbReference type="HOGENOM" id="CLU_3260486_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNK3"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="42" mass="4623" checksum="B7611FF64122B0A4" modified="2006-03-21" version="1">MCYKAALLVAPVGSRHGPLEEHAVCEWREKHGDMQQQMAGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GP29</accession>
    <name>Q2GP29_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_10275</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228202.1">
        <property type="nucleotide sequence ID" value="XM_001228201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GP29"/>
    <dbReference type="FunCoup" id="Q2GP29">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="GeneID" id="4396825"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10275"/>
    <dbReference type="eggNOG" id="ENOG502QU6M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021993_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GP29"/>
    <dbReference type="OMA" id="ALQLLYW"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000308">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="65"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ83871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="482" mass="51761" checksum="F0012824D18C065E" modified="2006-03-21" version="1">MATAASDGPAKREQHIDSNTTQNGGEDTEKAVPLGDATDEESGAGSPQPDSKLQRWNDTPLNIFRYFTTIYCFILMGMTDGALGALLPYIEGYYSISYTVVSLVFLSPFVGYLLAALLNNLIHHHFGQLGVAILGPISRLIGIIPLIFHPPYPALPVILLFTGFGNGIEDSAWNAWVGNMHRANELLGFLHGAYGLGATIGPLIATAMVTRAGLPWYTFYYVMVGADGLALFLTVPAFWRATAKVHRAAMLEASNGAPRTTTRTVLRSPVVWLVALFLLGYVGAEVSLGGWITTFMLRVRHAPPFMAGLTATFFWLGLTVGRVVLGFVTGMIGEKLAIAAYLLLSVALQLLYWLVPNFAASATFVTFLGFFLGPLFPAAVVAATKLLPRDYHVSAIGFAAAFGGGGAALFPFAVGAIAQSKGVEVLQPVVLAILVFILLMWLLLPGGLRMGGLEKARDNNEKVGDDFRKGMAWVRGRSAKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GP32</accession>
    <name>Q2GP32_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228199.1">
        <property type="nucleotide sequence ID" value="XM_001228198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GP32"/>
    <dbReference type="GeneID" id="4396822"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10272"/>
    <dbReference type="HOGENOM" id="CLU_1510418_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GP32"/>
    <dbReference type="OrthoDB" id="10408012at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="178" mass="20274" checksum="5F51A900AFC463EC" modified="2006-03-21" version="1">MSAFLLQETTCPYPTFIYSSSSLSKPVNEPDQLNTETQCSKTPRKSFTISAACGQRRDLSPMGPMARARLFGFSESEPFNGLDKHRFDPHDPLQGSEAETFREYWAQRNKTQIARAVLKSKANLENPTKALINVEGEEEEEDACGEDTKIDENTRRRLEEARLNAQKNSQMTKDQKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GR17</accession>
    <name>Q2GR17_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_09587</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227514.1">
        <property type="nucleotide sequence ID" value="XM_001227513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GR17"/>
    <dbReference type="GeneID" id="4396354"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09587"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_6_1"/>
    <dbReference type="InParanoid" id="Q2GR17"/>
    <dbReference type="OMA" id="AMPIVYN"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF158">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="59"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ83183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="519" mass="56441" checksum="D7449859C99C53CC" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRJ3</accession>
    <name>MED7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Mediator of RNA polymerase II transcription subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Mediator complex subunit 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MED7</name>
        <name type="ORF">CHGG_09411</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227338.1">
        <property type="nucleotide sequence ID" value="XM_001227337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRJ3"/>
    <dbReference type="SMR" id="Q2GRJ3"/>
    <dbReference type="FunCoup" id="Q2GRJ3">
        <property type="interactions" value="639"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GRJ3"/>
    <dbReference type="GeneID" id="4394896"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09411"/>
    <dbReference type="eggNOG" id="KOG0570">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065214_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRJ3"/>
    <dbReference type="OMA" id="MMQDHLD"/>
    <dbReference type="OrthoDB" id="10253553at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009244">
        <property type="entry name" value="Mediatior_Med7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044888">
        <property type="entry name" value="Mediatior_Med7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428:SF11">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05983">
        <property type="entry name" value="Med7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000303198" description="Mediator of RNA polymerase II transcription subunit 7">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="263" mass="29315" checksum="814491DD9B4B0511" modified="2006-03-21" version="1">MDNHEDDPNRVTALWPDPPSFWRDFTPENVERYDSLKEDYTHQQGLSADADADAVIRIPSIPEELINLQPPPEPTEGTWTLFTETQTLTETLQSLEEAGIQRLGPTSDIDRDSKHLDRGFQLKKLVKSLLLNYLELVGLMGYNPDHAAEKIEDLKILLLNFHHTLNEYRPHHAREQLIQIMHAHGDQMRAETAGIRSVVDKAKRMIEGLASIQVPQLDNTESDTGGKGAVGVGVGVGGAKAQRTRLERGREAVGWAGVEGDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GST8</accession>
    <name>Q2GST8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_08966</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226893.1">
        <property type="nucleotide sequence ID" value="XM_001226892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GST8"/>
    <dbReference type="STRING" id="306901.Q2GST8"/>
    <dbReference type="GeneID" id="4395555"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08966"/>
    <dbReference type="eggNOG" id="KOG2820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GST8"/>
    <dbReference type="OMA" id="MECWRTD"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050031">
        <property type="term" value="F:L-pipecolate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF46">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="140"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ84952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="468" mass="50083" checksum="9367CF46C7076649" modified="2006-03-21" version="1">MAAGVCIGQISVCRGSPYNQQLGNRTNTQSHNLGRFLRQTPPASTPAELLGPTMLIQRTRRWVTRPRRNGANKTHPPTWEPKGATMRLGCSWVGDASPPAPGAAPSSGGLKPKLTGMDYARKSWANVLSLASKNPALAARVRELPNPDAIREALGTGGSSGSWGYINNNSGWANATASMAWLFDQVQKTGRVNFVAGTVISLERAEDTVTGAKLSDGRVLSADLVVVAAGAWTGSLVDLAGQTVATGQVLGYMDITEAEQEKLANMPVILNISTGLFIIPPTDRVLKIAQHAYGYLNPVTPANPPLPFSPSLTTQTPTPIFLPRTGLTDPDLTIPAAAAADLRRALREMIPWPALHDRPFTKTRLCWYADTADADFLVDYHPHWHGLFVATGDSGHAFKFLPVIGDKVVDCIVREPPLQFRGKWDWKVIVPKSGAAVAAFTEDGTRGGTPGLVLAEALGEVERVVPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GT90</accession>
    <name>Q2GT90_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2005-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Giovannoni S.J."/>
                <person name="Cho J.-C."/>
                <person name="Ferriera S."/>
                <person name="Johnson J."/>
                <person name="Kravitz S."/>
                <person name="Halpern A."/>
                <person name="Remington K."/>
                <person name="Beeson K."/>
                <person name="Tran B."/>
                <person name="Rogers Y.-H."/>
                <person name="Friedman R."/>
                <person name="Venter J.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 148.51</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2006-02" db="EMBL/GenBank/DDBJ databases">
            <title>Annotation of the Chaetomium globosum CBS 148.51 Genome.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Birren B."/>
                <person name="Lander E."/>
                <person name="Galagan J."/>
                <person name="Devon K."/>
                <person name="Nusbaum C."/>
                <person name="Ma L.-J."/>
                <person name="Jaffe D."/>
                <person name="Butler J."/>
                <person name="Alvarez P."/>
                <person name="Gnerre S."/>
                <person name="Grabherr M."/>
                <person name="Kleber M."/>
                <person name="Mauceli E."/>
                <person name="Brockman W."/>
                <person name="Rounsley S."/>
                <person name="Young S."/>
                <person name="LaButti K."/>
                <person name="Pushparaj V."/>
                <person name="DeCaprio D."/>
                <person name="Crawford M."/>
                <person name="Koehrsen M."/>
                <person name="Engels R."/>
                <person name="Montgomery P."/>
                <person name="Pearson M."/>
                <person name="Howarth C."/>
                <person name="Kodira C."/>
                <person name="Yandava C."/>
                <person name="Zeng Q."/>
                <person name="Alvarado L."/>
                <person name="Oleary S."/>
                <person name="Untereiner W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 148.51</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226741.1">
        <property type="nucleotide sequence ID" value="XM_001226740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GT90"/>
    <dbReference type="STRING" id="306901.Q2GT90"/>
    <dbReference type="GeneID" id="4394864"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08814"/>
    <dbReference type="eggNOG" id="ENOG502S5F4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043690_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GT90"/>
    <dbReference type="OMA" id="WHDKPHI"/>
    <dbReference type="OrthoDB" id="414322at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="412" mass="46431" checksum="AAF0F72B549161F1" modified="2006-03-21" version="1">MALDETPTFETPRPPAAADKPVEDAVADLLTLVITTSPTPSAPSTDLLSQILTSFREFCPELSRCRVILVLDTYDHISSTARLKKGHVTAEGARNYAEYKNNAKRLILDDYAPGRTEHRLEDLLEDYDEAEYGSTAYAQQTNTVPLAITKTEDERIIFVEPLQRLGFGLAVRSALRLTKTPYVWIQQHDWALVSDIPLRPLLTIMQQHSQPTAANLDDFETAKVPVKYVCFPSVRMLEYAKSDHVMQFPALRALTNLHKQNFSVAKLGDDGGGGGTVQKISLTPLFFWHDKPHVAETAHYLARVFPDRAALPRGAFIEDTIGHRARTVKKDAQWRKWACWLHYPDEGRRLCVRHLKGRTWRGTEGELAQKLEYMRLNRGGGVLDVRVEGVEVLDVTVQGGEVVDVRVEKQIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTK0</accession>
    <name>Q2GTK0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226631.1">
        <property type="nucleotide sequence ID" value="XM_001226630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTK0"/>
    <dbReference type="GeneID" id="4394883"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08704"/>
    <dbReference type="eggNOG" id="KOG2615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1532366_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTK0"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="18673" checksum="68064DC07E0E4C97" modified="2006-03-21" version="1">MGGSDTPGTLENDRGVDVGMAPSPPSHRLGQGNGRPSPHREYGMRGPSNRAAGPETVSWRDLPRKDQLCVITLARLSEPLVQTSIQSYMFYQLKWFGPTLSDAVISGQAGILQYVVPSGSVCRPGVAPDRLRLARSASFTAAQFLTAMLWGRIADSGRVGRKTVLMIGLAGTCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTM9</accession>
    <name>Q2GTM9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C-1-tetrahydrofolate synthase, cytoplasmic</fullName>
            <ecNumber evidence="8">1.5.1.5</ecNumber>
            <ecNumber evidence="7">3.5.4.9</ecNumber>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CHGG_08675</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="8"/>
    <dbReference type="EC" id="3.5.4.9" evidence="7"/>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226602.1">
        <property type="nucleotide sequence ID" value="XM_001226601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTM9"/>
    <dbReference type="FunCoup" id="Q2GTM9">
        <property type="interactions" value="1071"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GTM9"/>
    <dbReference type="GeneID" id="4395196"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08675"/>
    <dbReference type="eggNOG" id="KOG4230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003601_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GTM9"/>
    <dbReference type="OMA" id="QPIMFRR"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000006">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000245">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001123">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1510.10">
        <property type="entry name" value="Domain 2, N(10)-formyltetrahydrofolate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00766">
        <property type="entry name" value="THF_DHG_CYH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="17" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="20">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="21">
        <location>
            <begin position="143"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00017592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EAQ84661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="939" mass="99937" checksum="34726E64E47E5543" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTR8</accession>
    <name>Q2GTR8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Magnesium transporter protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_08636</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OST3/OST6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226563.1">
        <property type="nucleotide sequence ID" value="XM_001226562.1"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Oligosaccharyl transferase subunit (Gamma), putative"/>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="GH11935P"/>
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        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208997" description="Magnesium transporter protein 1" evidence="10">
        <location>
            <begin position="21"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ84622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="36706" checksum="48E72E1E993A47CA" modified="2006-03-21" version="1">MRLLTLLTTALLSAATGALAAKKTSEERFQLYHSKALSTSPVKLSEASYRELTATPRDYSVAVLLTAMDARYGCQLCREFQPEWELLARSWTGGDRKGDSRVVFGTLDFGDGRDVFMSLGLQTAPVLFFFPPTTGPHAPASPEPVRYDFTGGAQAAEVVHSWVARYLPDRPHPPIKRPINWMRWISTFVILSGGLTFSYVAWPYVLPVIQSRTVWAAITLISILLFTSGHMFNHIRNVPYVAGDGRGGISYFANGFQNQYGLETQIVAAMYGILALSSISLAIKVPRMTDPRNQGIAFLAWFGILFVVYSLLLSIFRGKNPGYTFSLPPFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTT0</accession>
    <name>Q2GTT0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_08624</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTT0"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08624"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
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        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
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        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="710"/>
            <end position="749"/>
        </location>
    </feature>
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        <location>
            <begin position="23"/>
            <end position="78"/>
        </location>
    </feature>
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        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ84610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="991" mass="112278" checksum="68298AE6B656B058" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTV9</accession>
    <name>Q2GTV9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_08595</name>
    </gene>
    <organism evidence="4 5">
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226522.1">
        <property type="nucleotide sequence ID" value="XM_001226521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTV9"/>
    <dbReference type="GeneID" id="4395102"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08595"/>
    <dbReference type="eggNOG" id="KOG0591">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_452830_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTV9"/>
    <dbReference type="OrthoDB" id="4584769at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053083">
        <property type="entry name" value="TF_kinase-domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44305">
        <property type="entry name" value="SI:DKEY-192D15.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44305:SF24">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE C03B1.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="94"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="599"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="611"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ84581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="631" mass="71399" checksum="69E841FC16D963D4" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU06</accession>
    <name>Q2GU06_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta-xylosidase C-terminal Concanavalin A-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_08548</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226475.1">
        <property type="nucleotide sequence ID" value="XM_001226474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GU06"/>
    <dbReference type="GeneID" id="4395435"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08548"/>
    <dbReference type="eggNOG" id="ENOG502QQH8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016508_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GU06"/>
    <dbReference type="OMA" id="QQDDRVW"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18617">
        <property type="entry name" value="GH43_XynB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF16">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="5">
        <location>
            <begin position="351"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ84534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="559" mass="62836" checksum="11A36E02A42C1CBA" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU32</accession>
    <name>Q2GU32_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226449.1">
        <property type="nucleotide sequence ID" value="XM_001226448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GU32"/>
    <dbReference type="GeneID" id="4395628"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08522"/>
    <dbReference type="eggNOG" id="ENOG502R72I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_383089_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GU32"/>
    <dbReference type="OrthoDB" id="3521097at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="722" mass="79592" checksum="BE8E6AD28C8D1BA0" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU92</accession>
    <name>Q2GU92_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_08462</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226389.1">
        <property type="nucleotide sequence ID" value="XM_001226388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GU92"/>
    <dbReference type="STRING" id="306901.Q2GU92"/>
    <dbReference type="PeroxiBase" id="4189">
        <property type="entry name" value="CgHalPrx01"/>
    </dbReference>
    <dbReference type="GeneID" id="4395348"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08462"/>
    <dbReference type="eggNOG" id="ENOG502QTVQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050230_0_2_1"/>
    <dbReference type="InParanoid" id="Q2GU92"/>
    <dbReference type="OMA" id="YFFQNER"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF7">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208620" description="Heme haloperoxidase family profile domain-containing protein" evidence="8">
        <location>
            <begin position="23"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="22"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ84448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="271" mass="29990" checksum="EB540AFBA9EF7D0C" modified="2006-03-21" version="1">MKSPTALLGCLSLACLMSEASSIPAWHPPGPGDLRGPCPMMNTLANHGILPHDGRAITKEAVIKAMKQGLNFDSTLAVVMFDQAVVANPEPNATFFTLDHLNRHNVLEHDASLSRTDAFFGSNHIFNQTIFDQTRRYWPEPVITTAHMANAKIARQIESKAFNPEYRFTESVENFSLGEMAAPFIAFGDLEEATVNRTLVEYFFQNERLPTELGWNVREEVVAVEAILRISNMIGKATSLITNQDSDGSAGSNCTKRGLRRGFHAAVRRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUE2</accession>
    <name>Q2GUE2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Cytochrome c oxidase subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Cytochrome c oxidase polypeptide VIIA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_08412</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the fungal cytochrome c oxidase subunit 7a family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226339.1">
        <property type="nucleotide sequence ID" value="XM_001226338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUE2"/>
    <dbReference type="FunCoup" id="Q2GUE2">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GUE2"/>
    <dbReference type="GeneID" id="4395131"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08412"/>
    <dbReference type="eggNOG" id="ENOG502SBM8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196969_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUE2"/>
    <dbReference type="OMA" id="ASYWWWG"/>
    <dbReference type="OrthoDB" id="2317211at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22888">
        <property type="entry name" value="CcO_VIIa_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014368">
        <property type="entry name" value="Cyt_c_oxidase_su7a_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034884">
        <property type="entry name" value="Cytochrome_c_oxidase_VIc/VIIs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037169">
        <property type="entry name" value="Cytochrome_c_oxidase_VIc_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02937">
        <property type="entry name" value="COX6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000283">
        <property type="entry name" value="COX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81415">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ84398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="61" mass="6837" checksum="17A6751CEE0FFBB3" modified="2006-03-21" version="1">MAVKPITGMLRRGLITDLGIALGLGLVFGNAFWYGYHVPRRDARDNFYKKLEEQRAAKLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUG9</accession>
    <name>Q2GUG9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_08385</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226312.1">
        <property type="nucleotide sequence ID" value="XM_001226311.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4394703"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08385"/>
    <dbReference type="eggNOG" id="ENOG502SF7G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_261829_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUG9"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="638"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1193"/>
            <end position="1225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ84371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1296" mass="145165" checksum="FA12DFF6B38B9F41" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUW4</accession>
    <name>Q2GUW4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_08240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAK10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225896.1">
        <property type="nucleotide sequence ID" value="XM_001225895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUW4"/>
    <dbReference type="FunCoup" id="Q2GUW4">
        <property type="interactions" value="548"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GUW4"/>
    <dbReference type="GeneID" id="4393572"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08240"/>
    <dbReference type="eggNOG" id="KOG2343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011757_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUW4"/>
    <dbReference type="OMA" id="QMEWIVQ"/>
    <dbReference type="OrthoDB" id="269405at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057983">
        <property type="entry name" value="NAA35-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057982">
        <property type="entry name" value="TPR_NAA35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04112">
        <property type="entry name" value="Mak10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25789">
        <property type="entry name" value="TPR_NAA35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAA35-like N-terminal" evidence="4">
        <location>
            <begin position="57"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="NAA35-like TPR repeats" evidence="5">
        <location>
            <begin position="264"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ86987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="692" mass="77565" checksum="E3B6D7938C4F3E2C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV91</accession>
    <name>Q2GV91_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225769.1">
        <property type="nucleotide sequence ID" value="XM_001225768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV91"/>
    <dbReference type="GeneID" id="4394422"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08113"/>
    <dbReference type="HOGENOM" id="CLU_1147084_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GV91"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="242" mass="26196" checksum="15C7F40B8114AAAD" modified="2006-03-21" version="1">MQTGNAILSGPLRDGFGRGSRDIKAASELTAAVFVQNQKHASLTNNGLILDPSHQKGSLEVKLKPPPATEASRGERTFQPQSASRRPRAPHVFGARSGPMPGFAFLDRGVGCRDWRALSLVHRSTTAPPNTMDQEGRCHSRCRRRPRSERRRGSQNGNHSRALTSSLPGVHLLTPGPRLTGLEVGSEGGPGFSFVNGPHCSARLNDVGRQPLLVDRTAMAAGVKHEDRSGHHEPTPILRQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GW58</accession>
    <name>Q2GW58_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">GTP-binding protein rhb1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_07796</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Lipid-anchor</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the small GTPase superfamily. Rheb family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225452.1">
        <property type="nucleotide sequence ID" value="XM_001225451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GW58"/>
    <dbReference type="FunCoup" id="Q2GW58">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GW58"/>
    <dbReference type="GeneID" id="4394305"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07796"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_9_8_1"/>
    <dbReference type="InParanoid" id="Q2GW58"/>
    <dbReference type="OMA" id="SARHNEN"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019003">
        <property type="term" value="F:GDP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905589">
        <property type="term" value="P:positive regulation of L-arginine import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04137">
        <property type="entry name" value="RheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000273">
        <property type="entry name" value="GTP-binding protein Rheb homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ86543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="20766" checksum="013DF7242C95EBFA" modified="2006-03-21" version="1">MPTTLAKQRKIAIVGSRSVGKSSLAVRYVDGHFVESYYPTIENTFSKEIRYKGQEFATEIVDTAGQDEYSILNSKHFIGIHGYMLVYSVSSLQSFEMVQVIRDKILNHLGTETVPICIVGNKCDLRPEQRQVTAEEGKALADKHGCAWTEASARYNENVAKSFELLIGEVEKSVNPGEPSGGGKCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GW85</accession>
    <name>Q2GW85_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small acidic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_07769</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMAP family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225425.1">
        <property type="nucleotide sequence ID" value="XM_001225424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GW85"/>
    <dbReference type="GeneID" id="4393492"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07769"/>
    <dbReference type="eggNOG" id="ENOG502SNXT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_796934_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GW85"/>
    <dbReference type="OMA" id="HRQPLWM"/>
    <dbReference type="OrthoDB" id="10066125at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026714">
        <property type="entry name" value="SMAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028124">
        <property type="entry name" value="SMAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22175:SF0">
        <property type="entry name" value="SMALL ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22175">
        <property type="entry name" value="SMALL ACIDIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15477">
        <property type="entry name" value="SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small acidic protein-like" evidence="4">
        <location>
            <begin position="276"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ86516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="348" mass="38492" checksum="AD6FA031326E2BD9" modified="2006-03-21" version="1">MGEKSKKKTKEPKEEADVTTISADVYVKEKKKKSKKPKGDKSDLPEADAPVTAGFEELPDTPAKTKKRKNKDGKRKREVADALIETVTPVEAEEAEVEVEPPMKKKKDGKLDGDGKSEKKEKKRKSKEQKGKVVEGDLAEEATAEESQEAEVEDGKKKKKDKKEKKSKKSKKAAEPTEPQTTEPTEEEHESEKREKKKRKLRDEDGDEEMADIAAEETQAEEKDEAPEGKKKKDKKAKKEKSKKRKTTDTPAETPEKEAPAPAPTTAPNADLTERWNVHGLGGGASRQSKFMRLLGGKKHGVESAGEAKDGPRKRFDIGHVSQELEKQFDAGIQMKFGGGGQRKGLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWB4</accession>
    <name>Q2GWB4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">High-temperature-induced dauer-formation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225396.1">
        <property type="nucleotide sequence ID" value="XM_001225395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWB4"/>
    <dbReference type="STRING" id="306901.Q2GWB4"/>
    <dbReference type="GeneID" id="4393462"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07740"/>
    <dbReference type="eggNOG" id="KOG2226">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007392_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWB4"/>
    <dbReference type="OMA" id="IFEDDKW"/>
    <dbReference type="OrthoDB" id="432953at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="649"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="879" mass="97288" checksum="13F9A640780325AA" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWJ5</accession>
    <name>FAL1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent RNA helicase FAL1</fullName>
            <ecNumber>3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">FAL1</name>
        <name type="ORF">CHGG_07659</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225315.1">
        <property type="nucleotide sequence ID" value="XM_001225314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWJ5"/>
    <dbReference type="SMR" id="Q2GWJ5"/>
    <dbReference type="FunCoup" id="Q2GWJ5">
        <property type="interactions" value="566"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GWJ5"/>
    <dbReference type="GeneID" id="4393890"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07659"/>
    <dbReference type="eggNOG" id="KOG0328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GWJ5"/>
    <dbReference type="OMA" id="TRFHDFK"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18045">
        <property type="entry name" value="DEADc_EIF4AIII_DDX48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000498">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000255985" description="ATP-dependent RNA helicase FAL1">
        <location>
            <begin position="1"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="58"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="239"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box">
        <location>
            <begin position="176"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="71"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="394" mass="44606" checksum="0BA0C862416231A3" modified="2006-03-21" version="1">MADGAGIDRKADEKIQFSTSKEVTVHPTFESMSLKESLLRGIYAYGYESPSAVQSRAIVQICKGRDTIAQAQSGTGKTATFSISMLQVIDTAVRETQALVLSPTRELATQIQSVVMALGDYMNVQCHACIGGTNVGEDIRKLDYGQHIVSGTPGRVADMIRRRHLRTRHIKMLVLDEADELLNQGFREQIYDVYRYLPPATQVVVVSATLPYDVLDMTTKFMTDPVRILVKRDELTLEGLKQYFIAVEKEDWKFDTLCDLYDTLTITQAVIFCNTRRKVDWLTDKMREANFTVSSMHGDMPQKERDSIMQDFRQGNSRVLISTDVWARGIDVQQVSLVINYDLPSNRENYIHRIGRSGRFGRKGVAINFVTSEDVRILRDIECMWLPSPCFSCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWQ7</accession>
    <name>Q2GWQ7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225253.1">
        <property type="nucleotide sequence ID" value="XM_001225252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWQ7"/>
    <dbReference type="GeneID" id="4393737"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07597"/>
    <dbReference type="HOGENOM" id="CLU_3014022_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWQ7"/>
    <dbReference type="OMA" id="YGTHASN"/>
    <dbReference type="OrthoDB" id="3549921at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="56" mass="6022" checksum="3090D2CD6CE0C093" modified="2006-03-21" version="1">MPGTNQPWKSVWPAASGVADQATTLPSNLSAEEMTNQRSFGSHASNTKGRIVHLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWU9</accession>
    <name>Q2GWU9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_07555</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225211.1">
        <property type="nucleotide sequence ID" value="XM_001225210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWU9"/>
    <dbReference type="GeneID" id="4393264"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07555"/>
    <dbReference type="HOGENOM" id="CLU_924384_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWU9"/>
    <dbReference type="OrthoDB" id="4574248at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="176"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ86302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="301" mass="33899" checksum="AFF1FC0979969776" modified="2006-03-21" version="1">MNFKVLQRPWDQSSRIFFGTPHFGADRNQWLSIAKALGKVSSKAKGEPSTLVEAMTQNSRGLVDISEDFVHVAPNYTIKTVYETQKMKSTGQLVVPMMSTRMFGLQQEEMPIEADHLSMCQFNDKDHPGFELVCSFIRKVIKKVPEPRVSERPIQMDQTPKIRVGNILGRPIYIDTPPMHQGSANPTGNTRSNMNGLPSVMPSHEQPLLPDPENRDLSTKAQPATVPLALPTPTPQPLRLDMAVPRVVPIEWKLEDAVKLLQKDIPVPRVVPVECESEKAVKQSRWSHFSRMMGGRIRYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWW6</accession>
    <name>Q2GWW6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_07538</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225194.1">
        <property type="nucleotide sequence ID" value="XM_001225193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWW6"/>
    <dbReference type="STRING" id="306901.Q2GWW6"/>
    <dbReference type="PeroxiBase" id="4193">
        <property type="entry name" value="CgHalPrx02"/>
    </dbReference>
    <dbReference type="GeneID" id="4393324"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07538"/>
    <dbReference type="eggNOG" id="ENOG502QTVQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050230_0_2_1"/>
    <dbReference type="InParanoid" id="Q2GWW6"/>
    <dbReference type="OMA" id="DNHDFNQ"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF7">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209089" description="Heme haloperoxidase family profile domain-containing protein" evidence="8">
        <location>
            <begin position="18"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="18"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ86285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="283" mass="31576" checksum="DBD9A0D9F308CC8F" modified="2006-03-21" version="1">MKTLFLLTLAAFTPVFAGFDTWAPPGPYDVRAPCPMLNTLANHGFLPHDGHEITREQTENALFDALHIDKMLGSSLFDFAMTTNPVANSTTFSLNDLGNHNVLEHDASLSRSDAYFGNTLTFNQTVFDETKSYWTDETVTIEMASNARLARIKTSNATNPTYSMSELGNGFTKGESAAYVVIFGDKISGTVPRAWVEWLFEIALKTQPSTPSIKPTQTPSSPTRLLLKRLGRQLMLIVPRPIRLRVLRNTPPLRLITKNKPREMAPNLLILAVHKRATSMQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX17</accession>
    <name>Q2GX17_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_07487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225143.1">
        <property type="nucleotide sequence ID" value="XM_001225142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX17"/>
    <dbReference type="GeneID" id="4394574"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07487"/>
    <dbReference type="eggNOG" id="ENOG502SIJ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034964_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GX17"/>
    <dbReference type="OMA" id="FGMMNVE"/>
    <dbReference type="OrthoDB" id="5279008at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="14"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ86234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="494" mass="54946" checksum="3D60C72F4CE0AE5E" modified="2006-03-21" version="1">MSGTTVAAMDPQLGSGLVQIPLEVLIRITHYISTTDLGNVRLSCKALEQGLFNFFSHEFFRKKQFMVLTESLQALINISKHPNLSPFLKHVIIATDRPAPQYYNSSRNNESRARLEVAYADQMQLMAAGGLRDMLAEAFANLPNLETVDIRDFNSPSRSRDGRGTEWRSWGANTLAASTGNPVTTGTRNTQDPYLSQIFSAVTAALAVAQARPNSLEVLTRPSARSGFISFTLHDNAFYIPPRMEAAISPVLANLKSLHLILGLTNNARMRPFMFQKFLSLTINLAWLRMNFKDSSWDDQEEVLSWLALKDAQKPNASFDMAPIQLPLERLDLGDSELKPETVLNLVVKFAPTLTSLYLRRVCLINEISDHTTTKINPWDRCLTVLSKVRGLNLRTLDLSQIAHRNSGFRGNVPFKPTGDAPETRDWTCSTNLVTLDKAIAQAIAIMAPVWPQEPDPDQMDEDDEDEGEDEDDDDSEVSSDEEGGDEGDGDADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXM4</accession>
    <name>Q2GXM4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_07280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224936.1">
        <property type="nucleotide sequence ID" value="XM_001224935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXM4"/>
    <dbReference type="FunCoup" id="Q2GXM4">
        <property type="interactions" value="344"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GXM4"/>
    <dbReference type="GeneID" id="4394426"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07280"/>
    <dbReference type="eggNOG" id="KOG1234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_5_0_1"/>
    <dbReference type="InParanoid" id="Q2GXM4"/>
    <dbReference type="OMA" id="FMTNKGS"/>
    <dbReference type="OrthoDB" id="201153at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="6">
        <location>
            <begin position="446"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="195"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ86027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="773" mass="84443" checksum="206740382A1FCB33" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZ34</accession>
    <name>Q2GZ34_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_05212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224426.1">
        <property type="nucleotide sequence ID" value="XM_001224425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZ34"/>
    <dbReference type="GeneID" id="4391850"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05212"/>
    <dbReference type="eggNOG" id="ENOG502RS7T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_2_4_1"/>
    <dbReference type="InParanoid" id="Q2GZ34"/>
    <dbReference type="OMA" id="IMQEVGF"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ88593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="20094" checksum="429D1E2125E6594B" modified="2006-03-21" version="1">MGRIMNGSFSDPKEIVRKAFDQLEPGGYLEIQDMACPLGCDDGTLKKDSDLWLWVTTLMKAMEIAQRPLTFAQQWKTFLEEVGFEDVVEIVHKWPINTWARDPKYKTLGRWSLLNTDQVIEPAILAPATRFLGWSHEDAMALATNARKAIKDPRVHSYWPMHFVYGRKPGGKAAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H049</accession>
    <name>Q2H049_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_04847</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224061.1">
        <property type="nucleotide sequence ID" value="XM_001224060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H049"/>
    <dbReference type="GeneID" id="4391843"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04847"/>
    <dbReference type="HOGENOM" id="CLU_997488_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H049"/>
    <dbReference type="OrthoDB" id="10375892at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208789" evidence="3">
        <location>
            <begin position="23"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ88228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="279" mass="30523" checksum="C0D6EF5C929F4AFD" modified="2006-03-21" version="1">MRSSFTATWPLVLSMVHAFANGLPIPPHKDTAEPAAPALAAPPPPPPVLISQDTGVAAELACVFRTALRKAGYAADVLRRKGGRYGGGDVVNDGEALQGQLHYLRRRGGEVDSPRTEGVTGHGDSVSGSQEGIAEDLGRLLRKLVPFYPAVFTLPSVAIGVGLMLVSFVAIWCGFVCRDALGKGRWLRWGAREGRSRLRGEEPVNWDLREKGEELLDERQGGYGEERYRDEKAGFDEERYRDEYVSLMFEDIEDIEDVEESESAVDLVESMVAAAGVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0I8</accession>
    <name>Q2H0I8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_04708</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223922.1">
        <property type="nucleotide sequence ID" value="XM_001223921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0I8"/>
    <dbReference type="STRING" id="306901.Q2H0I8"/>
    <dbReference type="GeneID" id="4392735"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04708"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008514_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H0I8"/>
    <dbReference type="OMA" id="CLRIHAN"/>
    <dbReference type="OrthoDB" id="747253at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057029">
        <property type="entry name" value="TPR_fung_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057027">
        <property type="entry name" value="TPR_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF27">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23276">
        <property type="entry name" value="TPR_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23279">
        <property type="entry name" value="TPR_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Pentatricopeptide repeat-containing protein-mitochondrial" evidence="7">
        <location>
            <begin position="348"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="382"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeats fungi 2" evidence="8">
        <location>
            <begin position="480"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="432"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="539"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="539"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ88089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="68846" checksum="56E266BF86DF9E59" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0N3</accession>
    <name>Q2H0N3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CSC1/OSCA1-like 7TM region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_04663</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223877.1">
        <property type="nucleotide sequence ID" value="XM_001223876.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4391786"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04663"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002458_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H0N3"/>
    <dbReference type="OMA" id="FVQFNHQ"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF20">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="880"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="932"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="989"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1027"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1061"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="197"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="388"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="789"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="946"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="1242"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="473"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="596"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1119"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1149"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ88044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1321" mass="146851" checksum="7268CEAB63D6F961" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1E9</accession>
    <name>Q2H1E9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_04397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223611.1">
        <property type="nucleotide sequence ID" value="XM_001223610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1E9"/>
    <dbReference type="GeneID" id="4392721"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04397"/>
    <dbReference type="eggNOG" id="ENOG502SNS3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060131_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H1E9"/>
    <dbReference type="OMA" id="DANPEHM"/>
    <dbReference type="OrthoDB" id="4738875at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ87778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="294" mass="33967" checksum="735BB0CE3962CBF1" modified="2006-03-21" version="1">MTASRTSIFHRMHHDAWATQSQQCASEAPSVPNSLVKAPSPALNPRPRLGLPTDIEAVTNVIIKTMPLDPQWDYRFPYRHQYPEDHHRYTRMLFEYFLDPEYDDWVVMVIEDSPKPEAPSEVVAFGVWDVSYINKRRYGPGYKTQDRKFRCSWPSTADYPCKTRKDANHEHFNEFWKGQIRAYKRFFGSIGPEQIHLQILATLPDFQRRGHGSSLCKWAMELVMSDSLNDMSVMASPMGNELYTWLGFEDVGAFYIQVAGESQRLVLHAMMYRPTKLRTATSRKDADGSCCVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1N1</accession>
    <name>Q2H1N1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223529.1">
        <property type="nucleotide sequence ID" value="XM_001223528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1N1"/>
    <dbReference type="FunCoup" id="Q2H1N1">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H1N1"/>
    <dbReference type="GeneID" id="4391832"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04315"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="InParanoid" id="Q2H1N1"/>
    <dbReference type="OMA" id="VEAMTHI"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="288" mass="29195" checksum="6B30785EA30640C1" modified="2006-03-21" version="1">MAPTTLSLAGKTAIVTGSGRENGIGAAIALTLAKNGARVAINYVSDSSAPRAAKVAANLQAAGGQVIVIQADVSTPAGAAKLVKDTLSGFKTDKIDILSLSPLIPRFSFLPPVLTCPPPKVNNAGAGTGQGKLLVDLTPEEVQQAFALNTFSTLYVAQAAAPHMPSGGRIVNIGTVVSRMNNMPGVGVYGASKAAQEYLTAALAAELGPRQGITVNTVAPGPTNTDAASWFPENDLRDEVSQKLAVGARLGKVAGDPEEIADAVLLVVSDAARWITGQYIAASGGVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1N7</accession>
    <name>Q2H1N7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_04309</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223523.1">
        <property type="nucleotide sequence ID" value="XM_001223522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1N7"/>
    <dbReference type="STRING" id="306901.Q2H1N7"/>
    <dbReference type="GeneID" id="4392037"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04309"/>
    <dbReference type="eggNOG" id="ENOG502SSIP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_688871_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H1N7"/>
    <dbReference type="OMA" id="NCTSAMH"/>
    <dbReference type="OrthoDB" id="6123at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01833">
        <property type="entry name" value="XynB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF31">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208698" description="SGNH hydrolase-type esterase domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="3">
        <location>
            <begin position="77"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ87690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="400" mass="43115" checksum="BDC971066CEC8819" modified="2006-03-21" version="1">MVSPPLSTLLLALAAPLTIHGAPTPTPTNTDTAPNPDTTICTNTTLAISLTLTQPLPSQHQQTTPLGNGVPLRIMPLGASITYGTASSDGNGYRAALRNHLVSGPGNKVNMVGTRQSGSMRDRDVEGWPGFRIAEVRAKAMAPGCVPHYRPNVVLVNAGTNDATQNFSVDGAGARMEGLVRDLWAASPRAVVVLSTLLVNKNAEAERNVRVINAQYVDLARRLREGERKRLVLVDMHGPDGPTTADLADDTHPNDAGYRKMADIWFKGLVAASDAGWLQAPESVAGVPTSPGRQSERTRRRSSLPTSIFIFRIRVRIGIRVGVGARRCYQTRSSRSTMNHGPRGARGKQRGLAVQGSAHVSQRQVARRRSEVAEGKRAVLWSPWAWEEVAEEGGEGWRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1T2</accession>
    <name>Q2H1T2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="11">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_04264</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Alpha-L-arabinofuranosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 62 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="11"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223478.1">
        <property type="nucleotide sequence ID" value="XM_001223477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1T2"/>
    <dbReference type="GeneID" id="4393034"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04264"/>
    <dbReference type="eggNOG" id="ENOG502QUZT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041805_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H1T2"/>
    <dbReference type="OMA" id="VNSWGAA"/>
    <dbReference type="OrthoDB" id="3156236at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08987">
        <property type="entry name" value="GH62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005193">
        <property type="entry name" value="GH62_arabinosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631:SF1">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03664">
        <property type="entry name" value="Glyco_hydro_62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208822" description="Alpha-L-arabinofuranosidase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="14">
        <location>
            <begin position="344"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="318"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ87645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="380" mass="40282" checksum="6765F3DB92E2C97A" modified="2006-03-21" version="1">MKLSKSDLSAALLASALPVAQAACSLPSSYKWTSTGALAQPRSGWANLKDFTYAPYNGKHLVYASYFGGNYGSMNFGLFSDWSSMGSASQNQMNSATVAPTLFYFAPKKVWVLAYQWGATPFSYRTSSDPTNPNGWSSAQPLFSGSISGSDTGPIDQTLISDGTNMYLFFAGDNGKIYRSSMPVGNFPGNFGSSSTVIMSGNKNDLFEAVQVYTVAGQSQKTYLMIIESIGSRGRYFRSYTSNNLGGSWTPQATSENAPFAGKANSGASWTNDISHGDLLRTSADETMTIDPCNLQLLYQGRSGDSSDYNSLPYRPGLLTLQGATGGSPNNPEPTGGTNPGTGGTVPKYGQCGGSGYTGPTTCASGSKCTFSNEWYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H291</accession>
    <name>Q2H291_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223319.1">
        <property type="nucleotide sequence ID" value="XM_001223318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H291"/>
    <dbReference type="FunCoup" id="Q2H291">
        <property type="interactions" value="475"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H291"/>
    <dbReference type="GeneID" id="4392070"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04105"/>
    <dbReference type="eggNOG" id="KOG1685">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026457_5_0_1"/>
    <dbReference type="InParanoid" id="Q2H291"/>
    <dbReference type="OMA" id="PQRAYKN"/>
    <dbReference type="OrthoDB" id="10251727at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="43734" checksum="363CA3284A9601B4" modified="2006-03-21" version="1">MSKSTAVARAADASVPVNPEQTLKACKALVAHIKKAAAEPRDDGKQNLLGDEETTVAETPVWLTLTTKKHIHDSHRLQPGKIVLPNPLNTNEELSVCLITADPQRWYKNAVADEFPEELRAKIGRVIDISHLRAKFKAYEAQRKLFSEHDVFLADDRIINRLPKALGKTFYKTTTKRPVPVVLMAPREKVDGKRVAAPKGKKPKRDPTENINARPIPEIVAEVQKAIGAAHVHLSPSTNTAVKVGYANWEPKKIAANVDTAARELVERFVPQKWQNVRNFYVKGPETAALPIYQTDELWLDDSKVVAEGQQPPSALPGKGQKTIGEKPNVGKKRKSLDAEPEPAAEEPVKEDRPKKKVKKAVPESNDDKLDKEISERKAKLKKQKKAAAKKAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2C8</accession>
    <name>Q2H2C8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_04068</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223282.1">
        <property type="nucleotide sequence ID" value="XM_001223281.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4392586"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04068"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_31_0_1"/>
    <dbReference type="InParanoid" id="Q2H2C8"/>
    <dbReference type="OMA" id="RGKMMAV"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="10"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="1004"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2496"/>
            <end position="2574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="447"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1004"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1178"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1276"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1283"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="1041"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="1236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ87449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="2575" mass="278135" checksum="F5CF9970E6F6E614" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2J0</accession>
    <name>Q2H2J0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Uracil permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_04006</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223220.1">
        <property type="nucleotide sequence ID" value="XM_001223219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2J0"/>
    <dbReference type="FunCoup" id="Q2H2J0">
        <property type="interactions" value="519"/>
    </dbReference>
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    </evidence>
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    <sequence length="555" mass="61212" checksum="242511A708E3F851" modified="2006-03-21" version="1"> </sequence>
</entry>
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        </source>
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        </source>
    </evidence>
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        </source>
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</entry>
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            </authorList>
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        </source>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="533" mass="57854" checksum="75B7FE1D524CBD99" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2Z4</accession>
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                <person name="Untereiner W.A."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000001056">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="EAQ87233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="108" mass="12321" checksum="CE0F7C1038AC092C" modified="2006-03-21" version="1">MCCGHSLRYYCGHMCARFTERCEKKCRVAKGLRISRRVRAMCKFGNSDTAMSLNAPVGWPDGYSTSEELLEDVNKQAKQQGYAIVKRRTHWDKKGAARHYDLVCDRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H369</accession>
    <name>Q2H369_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABC transporter domain-containing protein</fullName>
        </recommendedName>
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        <dbReference type="NCBI Taxonomy" id="306901"/>
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050334">
        <property type="entry name" value="Molybdenum_import_ModC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43514">
        <property type="entry name" value="ABC TRANSPORTER I FAMILY MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43514:SF4">
        <property type="entry name" value="ABC TRANSPORTER I FAMILY MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="29"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="617" mass="67321" checksum="BDC19ADCD6D21796" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H437</accession>
    <name>Q2H437_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein L37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_06578</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222673.1">
        <property type="nucleotide sequence ID" value="XM_001222672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H437"/>
    <dbReference type="FunCoup" id="Q2H437">
        <property type="interactions" value="478"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H437"/>
    <dbReference type="GeneID" id="4391095"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06578"/>
    <dbReference type="eggNOG" id="KOG3475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150908_2_1_1"/>
    <dbReference type="InParanoid" id="Q2H437"/>
    <dbReference type="OMA" id="RMAYLKH"/>
    <dbReference type="OrthoDB" id="10259236at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000001">
        <property type="entry name" value="Ribosomal protein L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00547">
        <property type="entry name" value="Ribosomal_eL37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_eL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018267">
        <property type="entry name" value="Ribosomal_eL37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01077">
        <property type="entry name" value="RIBOSOMAL_L37E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ89959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="95" mass="10507" checksum="258EEE6884AC0C68" modified="2006-03-21" version="1">MTKGTSSFGKRHNKTHGLCRRCGRRSLHNQKKVCAGCGYPAAKTRKYNWSEKAKRRKVTGTGRMRYLSTVSRKFKNGFQTGVPKGAQGPTVSASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4E1</accession>
    <name>Q2H4E1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar ATP synthase subunit E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_06474</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222569.1">
        <property type="nucleotide sequence ID" value="XM_001222568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4E1"/>
    <dbReference type="FunCoup" id="Q2H4E1">
        <property type="interactions" value="651"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H4E1"/>
    <dbReference type="GeneID" id="4391422"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06474"/>
    <dbReference type="eggNOG" id="KOG1664">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073641_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4E1"/>
    <dbReference type="OMA" id="QHMMAFI"/>
    <dbReference type="OrthoDB" id="10263003at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="entry name" value="ATP synthase, E subunit, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45715">
        <property type="entry name" value="ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160527">
        <property type="entry name" value="V-type ATPase subunit E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ89855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25534" checksum="158D797E6976CC70" modified="2006-03-21" version="1">MSQIHSLSDDQVGQELRKMTAFIKQEATEKAREIEIKADEEFAIEKSKLVRQETDAIDTAYQKKFKQATMSQQTTRSTVANKTRLRVLGARQALLDDIFSAAADQLGDAAKDPARYEEVLKGLVLEGFYAMGEPELQIRARKADYEIVRKAIDAAAAEYKEKVGSDVKATIDEENNVPDGSTGGVVIVGGNGKIDLNNTFEARLDLLRESALPAMREALFGKNPNRKFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4E3</accession>
    <name>Q2H4E3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222567.1">
        <property type="nucleotide sequence ID" value="XM_001222566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4E3"/>
    <dbReference type="STRING" id="306901.Q2H4E3"/>
    <dbReference type="GeneID" id="4391420"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06472"/>
    <dbReference type="eggNOG" id="ENOG502S3E8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066479_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4E3"/>
    <dbReference type="OMA" id="LGQCPLT"/>
    <dbReference type="OrthoDB" id="2279611at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25150" checksum="BAFB5163A1DD8E62" modified="2006-03-21" version="1">MANQDSDRLTWSADGLFFAHGRISSLGFSVIVNNIKDEVPENGRQAARNLLYQEFPLTAGIVNAIFVFITFFVTLPGLATSSRKWLKLASYMAVVCLIFSMILGLYLWIQTLKLREDFAPRFTAQPNDIKSLMQVEFNCCGYFNSSSPAFVTDATCASKAAAAVMRGCATPISGFANVFIDNIFTALFGIVGFDVMFIMATACLLKDRKERERFQHIDEKNGFGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4J5</accession>
    <name>Q2H4J5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222515.1">
        <property type="nucleotide sequence ID" value="XM_001222514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4J5"/>
    <dbReference type="STRING" id="306901.Q2H4J5"/>
    <dbReference type="GeneID" id="4390618"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06420"/>
    <dbReference type="eggNOG" id="KOG3043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4J5"/>
    <dbReference type="OMA" id="PTEWYPP"/>
    <dbReference type="OrthoDB" id="2147163at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668:SF1">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G01940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="38"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="253" mass="27704" checksum="C5434205167FD202" modified="2006-03-21" version="1">MSTMPASHGHNEACCNIPPVVTTGYEPKGSYKEYDGLKTYATGPADATKGIIVIYDIFGYFDQTVQGADILATSDSQKYQVFIPDWFKGEPCPIEWYPPNTPEKQKDLGAFFGKNPPTGVAQALPGFVDTLNAKHPEIKSWGILRVKIVSLVTSSASNPFSAAAECHPAMVDPKEAESIKVPLILLASGEEPADKVQQFEANLKGAAAKHVETFQDQIHGWMAARADLSNDRVKEEYARGYKTVLDFFGKNWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4M1</accession>
    <name>Q2H4M1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_06394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222489.1">
        <property type="nucleotide sequence ID" value="XM_001222488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4M1"/>
    <dbReference type="GeneID" id="4390109"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06394"/>
    <dbReference type="HOGENOM" id="CLU_2158086_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4M1"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="111" mass="12603" checksum="DF39966A445FE473" modified="2006-03-21" version="1">MPQRRDLRAARRHRPGALNRPSRAIVAGWNNELADDRFGGCKDRWRKRYGGVHDSTSAFQNRQMPTDGLSKLVFAPALLCPDSAQRPQFAEELPILIPLPAIQKRERIKAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4N6</accession>
    <name>Q2H4N6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beige protein homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_06379</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May be involved in protein sorting and cell wall formation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222474.1">
        <property type="nucleotide sequence ID" value="XM_001222473.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H4N6"/>
    <dbReference type="GeneID" id="4390116"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06379"/>
    <dbReference type="eggNOG" id="KOG1786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000175_2_1_1"/>
    <dbReference type="InParanoid" id="Q2H4N6"/>
    <dbReference type="OMA" id="EMSNFHY"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056252">
        <property type="entry name" value="Alfy-like_Arm-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23295">
        <property type="entry name" value="Arm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2912"/>
            <end position="2935"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH-type PH" evidence="9">
        <location>
            <begin position="1690"/>
            <end position="1823"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="8">
        <location>
            <begin position="1862"/>
            <end position="2154"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="2288"/>
            <end position="2329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1131"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1160"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1579"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1588"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1659"/>
            <end position="1678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00054699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ89760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="2949" mass="329725" checksum="DAAB8D18D2CCFA67" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4R3</accession>
    <name>Q2H4R3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_06352</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
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            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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    </dbReference>
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    <dbReference type="FunCoup" id="Q2H4R3">
        <property type="interactions" value="839"/>
    </dbReference>
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    <dbReference type="GeneID" id="4391223"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06352"/>
    <dbReference type="eggNOG" id="KOG1164">
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    <dbReference type="HOGENOM" id="CLU_019279_2_7_1"/>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
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    </dbReference>
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            <begin position="12"/>
            <end position="239"/>
        </location>
    </feature>
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        <location>
            <begin position="260"/>
            <end position="331"/>
        </location>
    </feature>
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            <end position="280"/>
        </location>
    </feature>
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        <location>
            <position position="41"/>
        </location>
        <ligand>
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        </ligand>
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            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="EAQ89733.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="331" mass="37356" checksum="F2937C7C49B7A06D" modified="2006-03-21" version="1">MTTMDLRVGNKYRIGRKIGSGSFGDIYLGTNIISGEEIAIKLESVKAKHPQLEYEARVYKSLAGGVGIPFVRWFGTECDYNAMVLDLLGPSLEDLFNFCNRKFSLKTVLLLADQLISRIEENKNLTGTARYASINTHLGVEQSRRDDMESLGYVMLYFCRGSLPWQGLKAATKKQKYDRIMEKKMTTPTDVLCRGFPNEFAIYLNYTRSLRFDDKPDYSYLRKIFRDLFVREGFQYDYVFDWTVYKYQKNAQAIQQAAGNTAQATQGDPKDAQAAARKDAQALPRGTRKQITGDAPDTNRAVGGSDRMLRSAAKAQGAGSGYATNKYRPMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5N2</accession>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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            <begin position="21"/>
            <end position="73"/>
        </location>
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            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5Z0</accession>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
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            <end position="194"/>
        </location>
    </feature>
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        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ89306.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="568" mass="61323" checksum="90EC5CB76DC0865C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H618</accession>
    <name>Q2H618_CHAGB</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1562704_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H618"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="171" mass="18231" checksum="3282504A2B7D65EB" modified="2006-03-21" version="1">MWAVEPLPTTISQLAARWQTSHKMVVYALPLLCFASTECDPIKLVAPFMPWRIKGVMAIAMLLAVTGEFTASGGLATRCTHEGLVGTLAMADQVSMCEALLRLVVHHGSIGASEDWGVLKEAKAMLADLESLQGQGAAFFESQVLGPIKTLSSFAVEGLEAMLGGKSLVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H632</accession>
    <name>Q2H632_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221978.1">
        <property type="nucleotide sequence ID" value="XM_001221977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H632"/>
    <dbReference type="GeneID" id="4390451"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05883"/>
    <dbReference type="HOGENOM" id="CLU_009209_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H632"/>
    <dbReference type="OrthoDB" id="4325529at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060963">
        <property type="term" value="P:positive regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.20">
        <property type="entry name" value="Centromere DNA-binding protein complex CBF3 subunit, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052146">
        <property type="entry name" value="HOT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038279">
        <property type="entry name" value="Ndc10_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031872">
        <property type="entry name" value="NDC10_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022210">
        <property type="entry name" value="TF_GCR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37784:SF2">
        <property type="entry name" value="HIGH-OSMOLARITY-INDUCED TRANSCRIPTION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37784">
        <property type="entry name" value="PROTEIN MSN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12550">
        <property type="entry name" value="GCR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16787">
        <property type="entry name" value="NDC10_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="900"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="637"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1122" mass="127132" checksum="9B111586D96849B2" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6A4</accession>
    <name>Q2H6A4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221906.1">
        <property type="nucleotide sequence ID" value="XM_001221905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6A4"/>
    <dbReference type="GeneID" id="4391287"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05811"/>
    <dbReference type="HOGENOM" id="CLU_1481808_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6A4"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="182" mass="20311" checksum="74A77ADF19146C89" modified="2006-03-21" version="1">MSPQKEGDDPETFTTISSSEADTSELFTIVEARRSRPQPSAAPRQIKCLLRFASGYLHKPLRSVCVNAGVICTLHFVRIYANQLRLLRLVVNANAFLILEVSKSRLRCFFLSTMHVRIELSMLDIDGHDSPMPSRTQTPRISARPSDRAHQPSHKKTRHPGSPTPSFPPQTGFGARALHVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6G2</accession>
    <name>Q2H6G2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Selenoprotein W family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221848.1">
        <property type="nucleotide sequence ID" value="XM_001221847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6G2"/>
    <dbReference type="GeneID" id="4391315"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05753"/>
    <dbReference type="eggNOG" id="ENOG502S6UH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068510_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H6G2"/>
    <dbReference type="OMA" id="WVSTELM"/>
    <dbReference type="OrthoDB" id="60822at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417:SF2">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="19735" checksum="2333606303740E85" modified="2006-03-21" version="1">MVETTPQSSQPRLPRVTIQFCTQCKWMLRAAYYAQELLSTFSVSLGEVALQPATGGVFVVEIVTAAAAAEQPTTATDAATAASTPARLTKAVLWDRKVDGGFPEVKELKRRVRDVIQPGRDLGHVDRDYGRGNHGQGQGQDQGEGGDGEAKKEVKKEVKKEEGAGEEQTGKVCGVEGGAGCEDCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6R6</accession>
    <name>Q2H6R6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_05649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221744.1">
        <property type="nucleotide sequence ID" value="XM_001221743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6R6"/>
    <dbReference type="GeneID" id="4390266"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05649"/>
    <dbReference type="HOGENOM" id="CLU_2468856_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6R6"/>
    <dbReference type="OrthoDB" id="10507325at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="88" mass="9843" checksum="81AEE5DF007795A5" modified="2006-03-21" version="1">MARAGIAMVGVSCRSVCGTGLWFGGEWIDAWLSQGYPGSDPNRWMESESGERQELHPHFARTAVLSRNAGHNSLELSVRWARLEKRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H722</accession>
    <name>Q2H722_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_05543</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221638.1">
        <property type="nucleotide sequence ID" value="XM_001221637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H722"/>
    <dbReference type="STRING" id="306901.Q2H722"/>
    <dbReference type="GeneID" id="4390414"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05543"/>
    <dbReference type="eggNOG" id="ENOG502S48N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030366_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H722"/>
    <dbReference type="OMA" id="YAPNPDM"/>
    <dbReference type="OrthoDB" id="1939603at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167:SF3">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="242"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ88924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="399" mass="43125" checksum="CC42784C2275C784" modified="2006-03-21" version="1">MERAAPEYSQSGLPSPHPSVVGDTQSKAEPVDTASAAAQYATQQEARSASYSNSATPTSDYNVYPTTSRSATFTEMQRSYHPASNPNGSGGGMPQTPTSPSMPLPDGRSHQNPQPEQAKSDSTLPIDPSIAGASPTYATHNQYPPYAAPPQDMSQGYQHPGTPGLYTQPRPDWGGYGQQPGPYYRHPHLPPGARGRRCPWPPTSIWLDMVLTVPQVYSFVPIPGAQQHKRPRRRFEEIERMYKCGHNGCEKAYGTLNHLNAHVTMQAHGVKRTPELFKDIRREWKAKKKEEEARKAAAAEEDRQRQAAAAAAAAAAQNGGADPQAGVDAAQPPTSYPGSGTVQLPPIGYQTARYAGPPPAGMQQQMPEYSYPGYSPASPYGQSGQQMYNPHNGGQPPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H743</accession>
    <name>Q2H743_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_05522</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221617.1">
        <property type="nucleotide sequence ID" value="XM_001221616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H743"/>
    <dbReference type="GeneID" id="4391136"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05522"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006909_5_2_1"/>
    <dbReference type="InParanoid" id="Q2H743"/>
    <dbReference type="OMA" id="CFEKQSD"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ88903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="507" mass="55151" checksum="C87FCA257F8DC103" modified="2006-03-21" version="1">MSSPIPVNHIRHAFGPGKTVAVIGAGISGVCTAAHLLKQGLRVAVFERSGIAGGVWHYDGHISEDPPYPNSMPSRGDYQVSQPGEFAYATPPPEHYAEVADGIGSQNSHAVADLEVHFSPPGPCYAGLKNNVPTNLMTSALGSWPEGTEPFVNQRYLEEYIQTLAKDHGVDEVTSFHTRVDEVRRTADGSKWELRLVALEKGGTGPRLTEKTSHFDLVVVASGHYNMPRIPDTEGLKEWKLRYPSQITHSKQYRSPEAHQGQNVLVVGGGVSALDICRELDGVVTNTYQSVRGGKFDLPSSMLPKSVVRVAEVARFESRIASAGDGQVDAKGGIPGVVVLKDGVALENIHHVVLATGYITSYPFLPQLHSDDAPIAAAGEDLLVTSDGTMAHNLHRDIFYINDPTLAFVGVPYYVATFSLFDFQAQAVARVFAGKARLPGREEMRKEYERRVEEKGLGRGFHSLHGPGLEVAYVQELADWVNSTGAEIPGSHRCWLIRKSGRKDMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7G0</accession>
    <name>Q2H7G0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221500.1">
        <property type="nucleotide sequence ID" value="XM_001221499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7G0"/>
    <dbReference type="GeneID" id="4391215"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05405"/>
    <dbReference type="eggNOG" id="ENOG502QUHS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047583_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7G0"/>
    <dbReference type="OMA" id="FTVSTQF"/>
    <dbReference type="OrthoDB" id="4770823at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047975">
        <property type="entry name" value="Heme_bind_FMP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040572">
        <property type="entry name" value="heme_bind_FMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="427" mass="46087" checksum="65E5604A7E3FD428" modified="2006-03-21" version="1">MWDSPDVGRPSNGQVISQPDGFKFTDADSRYGDDYRSRLTPAKQAEPPLGILAALEGKCFRGPGINMIFRPNNGPPPGTDFPNPVNPPPPDGTSDNALEINLYEETLSFSKGVGRVPNRGSQKQPDIDLNAIMYLQSINDVTNPDTGDADGTPVSIHIENGMFMHVPSSDVNPKIGTTIGRCGTIPHGVAIHLQGFAPSSPSTHKAGPPHIPSINTTPFQTNSPSTQVTFPSLMAANQDTPRIPQDLTNFIQQGTITQEILNDPTTILRNANKTRNILSTSTLQMSSTPTAGIQTGGGVIGSAFLNGDATPSPTSRPNAKPLSVDFTLWIETVEYAIPIPASNPTPAYGPLEVLHQAIRFVVHPPRRVREPMVLRIRTVELQYLQVVLLEFDGLSWPHPSCATLRPECVVVPREHDGWGQRGVGCEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7N4</accession>
    <name>Q2H7N4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_05331</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221426.1">
        <property type="nucleotide sequence ID" value="XM_001221425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7N4"/>
    <dbReference type="GeneID" id="4390757"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05331"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_9_2_1"/>
    <dbReference type="InParanoid" id="Q2H7N4"/>
    <dbReference type="OMA" id="VRFCDSK"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF10">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="7"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="398"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="491"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ88712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="61106" checksum="0A2CBE1DE394B6AB" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H819</accession>
    <name>Q2H819_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230151.1">
        <property type="nucleotide sequence ID" value="XM_001230150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H819"/>
    <dbReference type="GeneID" id="4388930"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03635"/>
    <dbReference type="eggNOG" id="ENOG502RN7X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_644054_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H819"/>
    <dbReference type="OMA" id="NGESHIF"/>
    <dbReference type="OrthoDB" id="4589467at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="426" mass="46285" checksum="55BD5E179454BD50" modified="2006-03-21" version="1">MGLPLRNSTSFMNPPSGGPSLGGPSTTSESESDADPSEPLSYHHTGSRRANRPSRFHHLATLHHSSKGCLELSPRFQSLLDHDDHNTNANNTPITTRQPLHLHRHHTNQRRRLHRHRIRQAQQSSQEPRGSWLSDAAEGYSIARSSLQLPGEGGTTTTSNSSHNTGRGGGRSINRSRSSGDGSQGSSAGSERRPPSLERQDAFRDEKTTKKRRRGRQHQRGWEGEEEAGQDTNLGDEQAEVAELYRLGLLYDDEHERGAGFSLDGIVRDEPVYSLRVRPAKRSRRAERRWNGGHSGVLSLSVVDLAFSAFGADEALAGWMLSGPGSGSGSALSGAPAREVHRFGTETAHDTPGLTVVYELADDAVSAMSVDDDLLDSISVSEISFCGGEEDEMAWAMLDGNAMPATMDLEADEEVDPWVVLGQDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8G0</accession>
    <name>Q2H8G0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_03494</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230010.1">
        <property type="nucleotide sequence ID" value="XM_001230009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8G0"/>
    <dbReference type="STRING" id="306901.Q2H8G0"/>
    <dbReference type="GeneID" id="4388950"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03494"/>
    <dbReference type="eggNOG" id="KOG0025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_17_0_1"/>
    <dbReference type="InParanoid" id="Q2H8G0"/>
    <dbReference type="OMA" id="VILRTHC"/>
    <dbReference type="OrthoDB" id="7482721at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ91559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="43316" checksum="EF56C10CD0649DAC" modified="2006-03-21" version="1">MASNQVVLTYSATSNSPAEVIQAHHDQDGPVPGDEKPLPEATALVTFLVAPINPQDVMAIAGRYPVKPEYRHLDNPIPGNDGVARVEATNPPPPTTTTNHNPLPQPGDLVIPQRHGLGTWRRHAILPLSALTRLPLPNMNPLTTPTPTATSTPSAMIPHITIDPIAASMLRTVFLPAYLLTEDMRALRPGDWVVQNAAGSTVAQVVAQFVRRKGARVVAVVRERERERDGGCGGGGMADVDVVLTEREVREGGVGASGELKAAAERGRVVLGLDAVFGAAGEALAGLLSRGATYVNYGSLGGVDGVVRVSQKMVFWNEVRFRNFRLSEQLGKRSVMEQEDLLGWLADLIARGELRAPVVERIPVPMDGSFVEAFQEKVKGVLAAAAEKKIGHRKHVLDFAGAGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8V8</accession>
    <name>Q2H8V8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_03346</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229862.1">
        <property type="nucleotide sequence ID" value="XM_001229861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8V8"/>
    <dbReference type="FunCoup" id="Q2H8V8">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H8V8"/>
    <dbReference type="GeneID" id="4389271"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03346"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014456_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8V8"/>
    <dbReference type="OMA" id="CRRMKEV"/>
    <dbReference type="OrthoDB" id="289314at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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</entry>
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    </evidence>
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        <source>
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        </source>
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</entry>
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                <person name="Untereiner W.A."/>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="47639" checksum="73A61C5B1C8885B2" modified="2006-03-21" version="1">MRLLIASLPLRRHRPHLTKLTHFPLACIKTNPIQPIHHTASYSSSSSPIPFSPQTYLHTARQKFASQPPTLIHDTLSPTPSHLLTLSLADHVPALFPPGTSTATSTGPREQERPATLPQGHHLVYFPLQLPPSQLMPDGTDPAHRPGAPIVLRMWAGGEVVFCEGWDLHLCLYGRAALCVEEVDGPVLKGVEGDEKVFVEVRRGYGLGGVGREVVVEEVRRLVFMRERVGGVVEGGRVVRAYATPEFTFSLRPDATLLFHFSALTYNAHSIHIDPDYARNQEGYKGLLVHGPLTLVLMLSALRACLAKLSGQPSTGALPEGQSMPYVKSLSYRNLAPLYVNEDMKVCLRRINTEEIGQLRWDVWIEGPEGGIAVKGSAITTPASGTPEAWTLINSDCEEAGERMGGCVRLRKTESFNGWRGPESEFCIRDTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9A5</accession>
    <name>Q2H9A5_CHAGB</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="common">Soil fungus</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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        </lineage>
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Untereiner W.A."/>
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                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_001229714.1"/>
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    <dbReference type="STRING" id="306901.Q2H9A5"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016024_0_0_1"/>
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    <dbReference type="OMA" id="VHTFRHE"/>
    <dbReference type="OrthoDB" id="5418627at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
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        <location>
            <begin position="170"/>
            <end position="594"/>
        </location>
    </feature>
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        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
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        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
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        <location>
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            <end position="269"/>
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        </location>
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            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="432"/>
        </location>
    </feature>
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        <location>
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            <end position="464"/>
        </location>
    </feature>
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        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="574"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ91264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="689" mass="73823" checksum="ECD25B12EF719BE0" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9H2</accession>
    <name>Q2H9H2_CHAGB</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">CHGG_03132</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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    </evidence>
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        <source>
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    <sequence length="174" mass="18693" checksum="BFAECAF91564C9F6" modified="2006-03-21" version="1">MVVNILDGEIEEGARQNRWTLICGFPSNVESLVEFERKVSLVLPPSELCLPRDLEQVVIFEGDKYFPIPACFLQCVCGDLILALDSTEELDDAPHRKGHAVGVLPVCDVGFSHSLQRLMVPATGSSAAATDPAAPHERFAGSPLRTLGEVEPSSSFHAATLESGGCGFAKGCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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            <dbReference type="PubMed" id="25720678"/>
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            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <text evidence="8">Involved in pre-mRNA splicing.</text>
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        <subcellularLocation>
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        </subcellularLocation>
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    <dbReference type="eggNOG" id="KOG2609">
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0005681">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ91035.1"/>
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    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HA56</accession>
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        </submittedName>
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    <organism evidence="2 3">
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02898"/>
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    </dbReference>
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    <dbReference type="InParanoid" id="Q2HA56"/>
    <dbReference type="OMA" id="ITLNDCM"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018853">
        <property type="entry name" value="DUF2457"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10446">
        <property type="entry name" value="DUF2457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="265"/>
        </location>
    </feature>
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        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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            <end position="39"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="256"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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        </location>
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            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="567"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ90963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HA92</accession>
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            <fullName evidence="2">CRIB domain-containing protein</fullName>
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        <lineage>
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    <reference evidence="4" key="1">
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
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            <end position="238"/>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="114"/>
        </location>
    </feature>
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        </location>
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            <end position="255"/>
        </location>
    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ90927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="756" mass="82719" checksum="551769E7BC521265" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBE9</accession>
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        <recommendedName>
            <fullName evidence="4">Phosphatidylglycerophosphatase GEP4, mitochondrial</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">CHGG_02455</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228971.1">
        <property type="nucleotide sequence ID" value="XM_001228970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBE9"/>
    <dbReference type="STRING" id="306901.Q2HBE9"/>
    <dbReference type="GeneID" id="4388756"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02455"/>
    <dbReference type="eggNOG" id="KOG2961">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_696385_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HBE9"/>
    <dbReference type="OrthoDB" id="198652at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000165">
        <property type="entry name" value="HAD superfamily phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027706">
        <property type="entry name" value="PGP_Pase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010021">
        <property type="entry name" value="PGPP1/Gep4"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01668">
        <property type="entry name" value="YqeG_hyp_ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF25">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROPHOSPHATASE GEP4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09419">
        <property type="entry name" value="PGP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="43000" checksum="3D211386AF94E1AA" modified="2006-03-21" version="1">MQGLGQEWVPSIETRPGPRTRLPQISHSSRGWPKLLQLQPFFTVSKSVQAVTNNFGSFPPKSHLLSLTCINFPILPNWIFLARLEPFWRCNMNLNLSASLNIFKLLAKPSLCLPHTTVATFDDLPIPLNKAFSRNGRQVDIRAVVLDKDDCFAIPDHNEVHEPYKGRFEALRAAYPGRRLLIVSNTAGATSYDVNGKLASAVEASTGVSVLAHTVKKPGCGDEIMSYFRQHPETGVTGPHQIAIVGDRLATDMMLANMMGSWGVWVKNGIVPLEQKSIVSIRWLRGFLDPRTDAMFSSQGSKGGSGPPSSLEDIRRPSPQILLSKSAMVNIGFYRSRAASTPGASGSLGSSSGRTAGTRKPYVAAEQGIVQRALGRVGPTARGATSGMINSWPRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HC36</accession>
    <name>Q2HC36_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_02218</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228734.1">
        <property type="nucleotide sequence ID" value="XM_001228733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HC36"/>
    <dbReference type="SMR" id="Q2HC36"/>
    <dbReference type="STRING" id="306901.Q2HC36"/>
    <dbReference type="MEROPS" id="M01.A25"/>
    <dbReference type="GeneID" id="4389195"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02218"/>
    <dbReference type="eggNOG" id="KOG1046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003705_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HC36"/>
    <dbReference type="OMA" id="HDMAGFY"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000004">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF171">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="105"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="343"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="634"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ90283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="983" mass="110173" checksum="0F346971D4324406" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HC41</accession>
    <name>Q2HC41_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_02213</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228729.1">
        <property type="nucleotide sequence ID" value="XM_001228728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HC41"/>
    <dbReference type="GeneID" id="4389190"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02213"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_263822_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HC41"/>
    <dbReference type="OMA" id="GEACYLG"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF1">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209396" description="cellulase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="9">
        <location>
            <begin position="82"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="473"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="754"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ90278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1272" mass="139580" checksum="707CEC3ADEEDC3D1" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HC65</accession>
    <name>Q2HC65_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_02189</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228705.1">
        <property type="nucleotide sequence ID" value="XM_001228704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HC65"/>
    <dbReference type="GeneID" id="4389475"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02189"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="InParanoid" id="Q2HC65"/>
    <dbReference type="OMA" id="VAQFLCM"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF37">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="12"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ90254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="500" mass="54763" checksum="C19199D61CED969D" modified="2006-03-21" version="1">MALSPKWYQFLVGVFASLGSLLYGYDLGVIAQVIASQSFKTKFHPSNNEEAAVVSVFTGGAFFGAFAAGPMGDKLGRRWTILLGAIVFCLGGALQTGAQALSYLYSGRAIAGVGVGVLCMIVPLYQAELAHPSIRGRITALQQFMLGIGALAAAWISYGTYVGFDPTNDGQWRTSLGIQVIPAVFLAALILLFPESPRWLIDHDKQELGLQTLAKLHAHGDTNDAWVQAEYQQIQEAVAFDRANEAKSYAELFKDKSCFRRLFLACALQGGAQMTGVSAIQYYSVTIYGLMGIQGDDTLKYQAISSIIALVAQALCMLFIDKFGRRWPLIFGNLGNCVTFLIATILLAKFPPGANDNTAAAWGFIVVTWVYNFSFSATCGPLSWIIPAEVFDTKTRSKGVSIATMTSFALNTMIGQITGPAMKTVGYRYYILFVICNFTNALFFWAVLPETARRPLEEMNRLFTDAPLFVPTMDRKDWAGNDLERRVEEVKAKQESVHMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCC7</accession>
    <name>Q2HCC7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221348.1">
        <property type="nucleotide sequence ID" value="XM_001221347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCC7"/>
    <dbReference type="GeneID" id="4386381"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02127"/>
    <dbReference type="eggNOG" id="ENOG502RA5I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1156996_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCC7"/>
    <dbReference type="OMA" id="ACVTSCR"/>
    <dbReference type="OrthoDB" id="4567474at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209125" evidence="1">
        <location>
            <begin position="24"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="219" mass="22170" checksum="500ABFEE75C8A5B6" modified="2006-03-21" version="1">MAVLSSLPRALLLAFLVTAGVHGNPVDLGSGNAITCASVRCIAGTACLEIDGRPQCVPIKDAKCGNTVCEAGTVCCNSSCSLCVKPGHGVHCPYLPARRHHAFARKHSVARATCKAGQECCNESCGICVEPGKGCTKQLCVPGGEQCGKTVCPAGLQCCNSSCGVCTKPGEACTMQLCGEEPGKQCGKTVCPAGLTCCNSSCGICVPPGGACTQQVCLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCJ7</accession>
    <name>Q2HCJ7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_02057</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EAQ93822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001221277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCJ7"/>
    <dbReference type="STRING" id="306901.Q2HCJ7"/>
    <dbReference type="GeneID" id="4387346"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02057"/>
    <dbReference type="eggNOG" id="KOG2896">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009375_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HCJ7"/>
    <dbReference type="OMA" id="HYRFEYG"/>
    <dbReference type="OrthoDB" id="72772at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="49"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="541"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="573"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ93822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="624" mass="67968" checksum="2D195A3C54FC8C1D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDH4</accession>
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    </protein>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ93495.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="4386833"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01730"/>
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    <dbReference type="InParanoid" id="Q2HDH4"/>
    <dbReference type="Proteomes" id="UP000001056">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ93495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="35" mass="3959" checksum="681CFF1F99BF7A6E" modified="2006-03-21" version="1">MAGQPTHAYLVVENSPDSRPLAKPTERLSQYLWAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HE02</accession>
    <name>Q2HE02_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="InParanoid" id="Q2HE02"/>
    <dbReference type="Proteomes" id="UP000001056">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="322"/>
        </location>
    </feature>
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            <end position="128"/>
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    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="322" mass="36232" checksum="CF917DD4CCA5F477" modified="2006-03-21" version="1">MSSGDRYGRSSDHENAEERALRRMRDLKDARKRQYEKLNDWVREQEAAMARLRPARDRAEASHETVMSMVKKLKNKEAELQLMADSTTETKFRRSKNRPATDGRGNMTPEARRQYEEDRERRRRLTQREYDNLLEMYRRYKSEDQEAQEAYEQLKDKLKHNEGHIKKVKQHIQELEAEIDELEEYLHGQERRRRQQDQNPKFPPPDGSGGGSSGGYGGGSRGRDAPFGYGGGGYVARYDAGSRGGSGHGSQAYGGSGGYHRAAGQTHATPDGKTKQDVAGRLAALDLGGEKHRRESKPTASKTSKTKSAAGTTAGGSRSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEH3</accession>
    <name>Q2HEH3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_01381</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001220601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEH3"/>
    <dbReference type="GeneID" id="4387013"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01381"/>
    <dbReference type="eggNOG" id="ENOG502QVDR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038276_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HEH3"/>
    <dbReference type="OMA" id="ITWDADF"/>
    <dbReference type="OrthoDB" id="4084551at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028000">
        <property type="entry name" value="Pma1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14610">
        <property type="entry name" value="Psg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209172" evidence="3">
        <location>
            <begin position="21"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ93146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="309" mass="33144" checksum="C933158E88647981" modified="2006-03-21" version="1">MIPSKLTPAAWLMLLGTASAAPATEAEITVPAAAAALTDTPTDTGAAQPVPTNELGASAFSPCSNTDGEFKPFCLPKQHDIFYPGATPYVTWDTTFFPDPNNTLVKVVGFYTNITVPSDDPADDTHKDFEDAEAFSSETISALWGFYQWHPEGSLLSRPSVDQANITLRLVALPANGQAAQWHSGPTVNLRWKPKAPKKKKPGHTPTRADDDVLYVALPLVFGFAAIMIAGTFCWNRQLRRIGVGSVMGGRRVGGGASRRVGASKRDRARNRDKEQGIRLMESGGSGGMDSDEDGGWGEARQGAGRKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEY3</accession>
    <name>Q2HEY3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GED domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_01221</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
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        <location>
            <begin position="35"/>
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        <location>
            <begin position="628"/>
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        <location>
            <begin position="675"/>
            <end position="689"/>
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        <location>
            <begin position="726"/>
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    </feature>
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        <location>
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            <begin position="804"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="862" mass="96655" checksum="DBEB9AA08647C5AC" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HF47</accession>
    <name>Q2HF47_CHAGB</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CHGG_01157</name>
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        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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        <property type="protein sequence ID" value="EAQ92922.1"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="82" mass="8732" checksum="A6E439A67A1C513A" modified="2006-03-21" version="1">MSHSSSTHSYSHGSSSKPKSKGKGKDKSDRKGSSSRDKTKSTSNRDPYATSLSKSSGVTRYIEEPVHDGAWNPMAASGANRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFG9</accession>
    <name>Q2HFG9_CHAGB</name>
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        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_01035</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="EAQ92800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_001220255.1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="306901.Q2HFG9"/>
    <dbReference type="GeneID" id="4387375"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01035"/>
    <dbReference type="eggNOG" id="KOG2520">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_238973_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HFG9"/>
    <dbReference type="OMA" id="PNSMDFS"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09904">
        <property type="entry name" value="H3TH_XPG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000061">
        <property type="entry name" value="Single-stranded DNA endonuclease (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018805">
        <property type="entry name" value="YJL171C/Tos1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018807">
        <property type="entry name" value="YJL171C/Tos1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10287">
        <property type="entry name" value="YJL171C_Tos1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10290">
        <property type="entry name" value="YJL171C_Tos1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="10">
        <location>
            <begin position="836"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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</entry>
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                <person name="Untereiner W.A."/>
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        <source>
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</entry>
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        <recommendedName>
            <fullName evidence="6">PNPLA domain-containing protein</fullName>
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            <taxon>Sordariomycetes</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Untereiner W.A."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="match status" value="1"/>
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    </feature>
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        <location>
            <begin position="1293"/>
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        <location>
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        <location>
            <position position="170"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ92676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1324" mass="148889" checksum="C1D0722469EA9B83" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG75</accession>
    <name>Q2HG75_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">mRNA export factor MEX67</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_00779</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the export of mRNA from the nucleus to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NXF family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220000.1">
        <property type="nucleotide sequence ID" value="XM_001219999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG75"/>
    <dbReference type="FunCoup" id="Q2HG75">
        <property type="interactions" value="444"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HG75"/>
    <dbReference type="GeneID" id="4386878"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00779"/>
    <dbReference type="eggNOG" id="KOG3763">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024991_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HG75"/>
    <dbReference type="OMA" id="RWNPQAG"/>
    <dbReference type="OrthoDB" id="25872at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000296">
        <property type="entry name" value="mRNA export factor MEX67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22602">
        <property type="entry name" value="NXF_NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="12">
        <location>
            <begin position="391"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="565"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ92544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="589" mass="64100" checksum="892D07A9EFFEB6DD" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGJ6</accession>
    <name>Q2HGJ6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_00658</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219879.1">
        <property type="nucleotide sequence ID" value="XM_001219878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGJ6"/>
    <dbReference type="STRING" id="306901.Q2HGJ6"/>
    <dbReference type="GeneID" id="4386799"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00658"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_587925_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGJ6"/>
    <dbReference type="OMA" id="HEMNEYT"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="238"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ92423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="52354" checksum="AF96E9CDDD1BB8AB" modified="2006-03-21" version="1">METEGMETEGMETQGMETLEKLLAFNTVEDMRSAWLAIPQETRESNWLGMMKAALDSRLESVAMLLVATIGADRTPGWAVTDVFSVLVIWYSKLPEASRKDQQIQLPQLLIHLLRYFPPSSYRFQQWTLGQTMSDCDPDLVAEIYAALQEHKHPLHWNTKLKIAGCLTKNTKYKLAALRLFESLFDDPKADIHGRRCAALATELFTLPHDWKDRRTPVEVRLLAEAFERVVGRGLSPNIVTYTAMIRALCSTNQLDAAWKIYEVMRNAGTTPDAHVFSVLLNGAKRALRLGSAIRVMEEATPDALREPYIWNDLVHTILLAAMEEAPPITLSQTPDPLPAFPSMLKVYSKFFDVKPLEKLIPGGLDVPTNHIITDLAWHEKLGPFIDQLPAAAPDKLVRPGLEILGIMLTGYTKSLSTTDDILSFYTHFRGLLSKRDPLRYQTPRRRIHAPTTSFSILYLAAPGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGK3</accession>
    <name>Q2HGK3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219872.1">
        <property type="nucleotide sequence ID" value="XM_001219871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGK3"/>
    <dbReference type="GeneID" id="4386701"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00651"/>
    <dbReference type="eggNOG" id="ENOG502RZH4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1610554_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGK3"/>
    <dbReference type="OrthoDB" id="10050400at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031942">
        <property type="term" value="C:i-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040201">
        <property type="entry name" value="Mrg3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142:SF1">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ92416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="165" mass="17824" checksum="C6A353DEFC3CD74D" modified="2006-03-21" version="1">MSPEEVGLESGGTRTKLPGEEPTSSRRSALLPGPEALPRSLPYRHLDFADHPLIPRGDAPVHAMMEESKAWVSAAEQRASYLAAAQRWAQNAIDHASETQGEKRTPECDQACAVALSNLGSVLAMLGKNTEAREKFEQAVTLSKKLGFEDYAAAADARLQELPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGP7</accession>
    <name>Q2HGP7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Indoleamine 2,3-dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_00607</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219828.1">
        <property type="nucleotide sequence ID" value="XM_001219827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGP7"/>
    <dbReference type="STRING" id="306901.Q2HGP7"/>
    <dbReference type="GeneID" id="4387217"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00607"/>
    <dbReference type="eggNOG" id="ENOG502QSE1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1754197_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGP7"/>
    <dbReference type="OrthoDB" id="10262710at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF3">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ92372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16619" checksum="074EE80C722FC236" modified="2006-03-21" version="1">MGSLGHAMAPYTVLDDTRPDDMSLPAFMVSSTRGFLPRMDPIVTLPAEFDALESILQRMPVKTLSGEPGLLAESKLGDTVTKELPDLTDAVDKYKDNLPLMNALYRDYSFLASAYLLEPCHERFVRGEEYGLGREVLPANIARPIAKCAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH23</accession>
    <name>Q2HH23_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_00481</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219702.1">
        <property type="nucleotide sequence ID" value="XM_001219701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH23"/>
    <dbReference type="GeneID" id="4387439"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00481"/>
    <dbReference type="eggNOG" id="ENOG502S3BW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001613_8_4_1"/>
    <dbReference type="InParanoid" id="Q2HH23"/>
    <dbReference type="OMA" id="CKETHLE"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="3">
        <location>
            <begin position="177"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="437"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="901"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="907"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ92246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="945" mass="109414" checksum="457991028C2B6366" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH26</accession>
    <name>Q2HH26_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_00478</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219699.1">
        <property type="nucleotide sequence ID" value="XM_001219698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH26"/>
    <dbReference type="STRING" id="306901.Q2HH26"/>
    <dbReference type="GeneID" id="4387436"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00478"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_8_0_1"/>
    <dbReference type="InParanoid" id="Q2HH26"/>
    <dbReference type="OrthoDB" id="5231586at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="51"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ92243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="319" mass="36898" checksum="E1D6A69F20F65211" modified="2006-03-21" version="1">MSVQTQEARIILAIEAIRTTRNMSRRRAAGIYNVPETTLRDRMNGITPKADSYHGRSNLTKIEEEVIVQYVLDRDSRGLLPRPADVIDMANLLLQKRDARHVGKNWTSRLIARRPELDTRFNRVYDYHRGLCKNPAIIEPWFRRVASMRAKYGILDCDFYNFDETGFMMDMIRPGMVVTRSDRVGKLKAIQPGHREWATAICIIAGDGYVVPPFLVVKGRFHLASWYSEQQILDDWAVTTTTDGWTDNKTGLEWLQHFDEHTKHRRRGVYRMLVLKGHECHVNAEFEDYCKENNIVTIFVCLRIPRILPSLSMSGVTAS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-10-25" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>P84675</accession>
    <accession>Q2H7A2</accession>
    <name>PFM_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Putative fungistatic metabolite</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">CHGG_05463</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="thesis" date="2005" institute="University of Sydney, Australia">
            <title>The endophyte Chaetomium interacts with the pathogen Pyrenophora tritici-repentis (Dried.) Drechs. in wheat.</title>
            <authorList>
                <person name="Istifadah N."/>
            </authorList>
        </citation>
        <scope>PROTEIN SEQUENCE OF 19-30; 130-140 AND 149-165</scope>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Inhibits the growth of the fungus P.tritici-repentis.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221558.1">
        <property type="nucleotide sequence ID" value="XM_001221557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P84675"/>
    <dbReference type="SMR" id="P84675"/>
    <dbReference type="GeneID" id="4391031"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05463"/>
    <dbReference type="eggNOG" id="KOG4157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063916_3_1_1"/>
    <dbReference type="InParanoid" id="P84675"/>
    <dbReference type="OMA" id="CHCGTGL"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050832">
        <property type="term" value="P:defense response to fungus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051589">
        <property type="entry name" value="Sialate-O-sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964:SF5">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0929">Antimicrobial</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0295">Fungicide</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <feature type="chain" id="PRO_0000058345" description="Putative fungistatic metabolite">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="WSC 1" evidence="1">
        <location>
            <begin position="16"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="WSC 2" evidence="1">
        <location>
            <begin position="127"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 2; AA sequence." evidence="3" ref="2">
        <original>I</original>
        <variation>L</variation>
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 2; AA sequence." evidence="3" ref="2">
        <original>G</original>
        <variation>A</variation>
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 2; AA sequence." evidence="3" ref="2">
        <original>G</original>
        <variation>R</variation>
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 2; AA sequence." evidence="3" ref="2">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source ref="2"/>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="222" mass="23183" checksum="5BDDCAE27D9186D0" modified="2007-02-20" version="2">MQSVLVLAAIVPAALAQTYYGCYTEIPTRALTGAVPLIDYEAMTLADCEAHCTGFDLWGLEYGGECYCGNSLAQGSFPAFSTDCTMPCPGDATLTSVCGGPNRLSLYGTSETAPESLPYPHDPPVTTTQYEGCYTEVTEGARALAGASGFSLTDMTVGGCGGYCRDSGFTWFGLEYSAECYCGSELSVNSTLAAEEDCAMPCSGAAGEVCGGSNRLSVYQWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM36</accession>
    <name>Q2GM36_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_10968</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226235.1">
        <property type="nucleotide sequence ID" value="XM_001226234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GM36"/>
    <dbReference type="STRING" id="306901.Q2GM36"/>
    <dbReference type="GeneID" id="4397114"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10968"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_301103_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GM36"/>
    <dbReference type="OMA" id="ARTWEQG"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359:SF37">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="936"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="967"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="234"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="690"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ83150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="993" mass="110675" checksum="3BCA916379C5E503" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMD4</accession>
    <name>Q2GMD4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226137.1">
        <property type="nucleotide sequence ID" value="XM_001226136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMD4"/>
    <dbReference type="STRING" id="306901.Q2GMD4"/>
    <dbReference type="GeneID" id="4397158"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10870"/>
    <dbReference type="eggNOG" id="ENOG502SM1Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022339_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GMD4"/>
    <dbReference type="OMA" id="IWVPVWG"/>
    <dbReference type="OrthoDB" id="5281682at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="593" mass="66492" checksum="66CE0FC24F8B997D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMK2</accession>
    <name>Q2GMK2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_10802</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ82984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226069.1">
        <property type="nucleotide sequence ID" value="XM_001226068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMK2"/>
    <dbReference type="STRING" id="306901.Q2GMK2"/>
    <dbReference type="GeneID" id="4397108"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10802"/>
    <dbReference type="eggNOG" id="KOG0077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1224630_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GMK2"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
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        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARF"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
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    <keyword evidence="10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="162"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ82984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="226" mass="24192" checksum="517FBEFBA1EF1240" modified="2006-03-21" version="1">MYSLCDPPVPRQNHLLNRNRPSPTPKAPPLIHRPLATPARPRCCTTSVIRIPPHLSPCPLRGPQEPIYTLTPATGAVSRSTRPTSAASATATAQVASARLRRDYLAAGGVDGVVFVVDAADYEDGLKEARGEFEELLRVLGEIEEGRDCAAGKRMPVLVLGNKIDKPGAVAEEELRDLLGGLSSPVGVGNEMSRGREASRPVKLFMCSVVMGQGYKEGFAWLANNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN03</accession>
    <name>Q2GN03_CHAGB</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="4396307"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10651"/>
    <dbReference type="HOGENOM" id="CLU_2830992_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GN03"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="66" mass="7566" checksum="DD715E6DB3F40EDD" modified="2006-03-21" version="1">MTRIPHLGVKGETASAYIREEAEGAHNIDYRHTISVMAYSDTMGREKAEGIWQEKGWLMDLAVAWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNF2</accession>
    <name>Q2GNF2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228429.1">
        <property type="nucleotide sequence ID" value="XM_001228428.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="4396201"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10502"/>
    <dbReference type="eggNOG" id="ENOG502QRTD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031065_0_0_1"/>
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    <dbReference type="OMA" id="WTMKHRR"/>
    <dbReference type="OrthoDB" id="3527108at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="497" mass="55299" checksum="E5A14A7C846F2C37" modified="2006-03-21" version="1">MACASARPRSRLLLLVVALLFFRVLLLNITLLVRHASLDTRERSTQKPSHDESPPQIRDWEVAGWEPAGAVYREKAYKPEPAGPSSLPVPDPFPLLSENPPPAPGILRAPQVNRPPQKHSPEQTPLFVGFTRNWPLLLQCVVSYIAAGWPAEDIFVVENTGVMHANRDGKLTLQNPFYLNHTQLSMLGVNVITTPTLLTFSQLQNFYLWTALTNNHPYFFWTHQDVLVFSFEKDNNNNNNNKPPSPSHTTDRSTATTGSSATARPASLYANALATLRHLTTNPAHVLNTKPWAHHFFAYDHLTLVNRDVVLDVLGGWDTHIPFYASDCDAYLRARWAGLAQTESEIGIVLDVGSVMADLGALLRVPGCVGRLLEADGRGSEGVEGWGPEGEGAAYVESWERLVALGEKMQEEKYVGGGNGLRNQWQAEQKGGKGEPFYRDADGFEIGVQMMIETGRNVFAEKWGHRGCDVGRMGVVPEDAWRLERDWDEDEEDTGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNN7</accession>
    <name>Q2GNN7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase II subunit RPB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_10417</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228344.1">
        <property type="nucleotide sequence ID" value="XM_001228343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNN7"/>
    <dbReference type="FunCoup" id="Q2GNN7">
        <property type="interactions" value="869"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GNN7"/>
    <dbReference type="GeneID" id="4396837"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10417"/>
    <dbReference type="eggNOG" id="KOG1522">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038421_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GNN7"/>
    <dbReference type="OMA" id="FYFEVES"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07031">
        <property type="entry name" value="RNAP_II_RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="9">
        <location>
            <begin position="27"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ84013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="338" mass="36336" checksum="570E91AC4708A868" modified="2006-03-21" version="1">MDYDPMVMDDAEALGPVVKISQADPIRVKFELSNADIAFANSLRRVMLGEIPTIAIDLVEIEENSSVLADEFIAHRLGLIPLNADGVEGLLFARDCDCDGCCEHCSVRLTLHAKCTGDENMHVFARDLVPTGERINQVLGTPVVSDSEGLGALILKLRPGQEIKLECIAKKGIAKEHAKWAPSAAIGFEYDPHNKLRHTDFWYETDAKTEWPPSEYAAWEEPPQEGEPFDYDAVPNRFYFNVESAGNLPPDTIVSEGIKVIQQKLAGLIHELADEGGDGMNGDYNGPRSPEYGTGADGFGGGYTTPFGNGGSWGGAGGAGGTTPYGATPYGGGQNSWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPB3</accession>
    <name>Q2GPB3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228118.1">
        <property type="nucleotide sequence ID" value="XM_001228117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPB3"/>
    <dbReference type="GeneID" id="4396116"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10191"/>
    <dbReference type="HOGENOM" id="CLU_2454528_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPB3"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ83787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="89" mass="9974" checksum="F8A79295B025EE74" modified="2006-03-21" version="1">MGYIWVAPRSLKRTELGDDPSIGGSLPTWLAKVEYYEVDSKLLITPGRSDKLEEAINAASRLNKKNLGSRQRAAESRLRAAHSWASFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPP9</accession>
    <name>Q2GPP9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_10055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227982.1">
        <property type="nucleotide sequence ID" value="XM_001227981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPP9"/>
    <dbReference type="STRING" id="306901.Q2GPP9"/>
    <dbReference type="GeneID" id="4396036"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10055"/>
    <dbReference type="eggNOG" id="KOG0256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_1_2_1"/>
    <dbReference type="InParanoid" id="Q2GPP9"/>
    <dbReference type="OMA" id="MYGSEEF"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF63">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="48"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ83651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="439" mass="48352" checksum="7429BCECECBC30AB" modified="2006-03-21" version="1">MWEVMKNPWDRHSNPTGAVNLGVAENHLMETELRDYVAKHVTLRNSAVTYQDGPLGSHRLRDALARFLSRHLATHRPLDAAHIMVTNGVSSALEHVAWALADPGEAFLVGRPYYGEITLRLRPHVRTVPVSFGGLDPLSLPSVRCYEEALLRAREQGQVVRGLLLCSPHNPLGRCYPREVLMALVALCNKYQLHLVSDEVYALSVWRDAPAFTSVLSLDLDSLIDPALVHVLWGVSKDFGANGWRVGCLVSPRNPALRAALSSIAIYSYASSLADTVVAQVLQDDAFTSAYLAENRRRLAAAYAFTTNFLQRHGIPFTAGTQAALFVWADLGWAYRRWHPHAEREGQATSIADDVRDALRRHKVYLASGDNFDSESPDMFRIVFAHPRDRLEEGLRRIHQALLQGVIGVPAGDQPCAPVGIGTGMPVAAPASQGRSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQE9</accession>
    <name>Q2GQE9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_09805</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227732.1">
        <property type="nucleotide sequence ID" value="XM_001227731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQE9"/>
    <dbReference type="STRING" id="306901.Q2GQE9"/>
    <dbReference type="GeneID" id="4395995"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09805"/>
    <dbReference type="eggNOG" id="ENOG502RYSN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031730_4_2_1"/>
    <dbReference type="InParanoid" id="Q2GQE9"/>
    <dbReference type="OMA" id="HYTFPEL"/>
    <dbReference type="OrthoDB" id="5271017at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208347" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="18"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="25"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ83401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="227" mass="23972" checksum="83A08F50E265FAEE" modified="2006-03-21" version="1">MKLTLATAVLAAALAEAHYTFPSVDDSADWQYVRTTTNYQSNGPVTDVTSDQIRCYERDPGTGAPETYSVTAGKVLNYNAKASVSHPGPMAFYIAKVPEGETAATWDGSGEVWSKIYQEMPEFGASMTWSSDGAKSIPVTIPSCLSDGEYLLRVEHIALHSAGSAGGAQFYLSCAQLSVTGGSGSWSPKSKVAFPGAYSATDPGILINIYYPVPTSYTPPGPAVESC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQT5</accession>
    <name>Q2GQT5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227596.1">
        <property type="nucleotide sequence ID" value="XM_001227595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQT5"/>
    <dbReference type="STRING" id="306901.Q2GQT5"/>
    <dbReference type="GeneID" id="4396303"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09669"/>
    <dbReference type="eggNOG" id="KOG3429">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089470_0_2_1"/>
    <dbReference type="InParanoid" id="Q2GQT5"/>
    <dbReference type="OMA" id="TTANRYY"/>
    <dbReference type="OrthoDB" id="270639at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016150">
        <property type="term" value="F:translation release factor activity, codon nonspecific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052104">
        <property type="entry name" value="Mito_Release_Factor_mL62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075:SF54">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14706" checksum="BD90D4E1DDD9A511" modified="2006-03-21" version="1">MNWLRQGNGTSRSSPTESKATTTWPVTQLLGVLPKLLHSGVRDLKYYSRRNDCLTIQAQTQRSRSANADENHQKLFEEIQSLYRRTVPGETRPEKAKKYAALKKGANEARMKSKKLQSLKKSSRRGSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRL7</accession>
    <name>Q2GRL7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cell wall mannoprotein PIR1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_09387</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PIR protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227314.1">
        <property type="nucleotide sequence ID" value="XM_001227313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRL7"/>
    <dbReference type="GeneID" id="4395353"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09387"/>
    <dbReference type="eggNOG" id="ENOG502RKR1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049782_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GRL7"/>
    <dbReference type="OMA" id="WYECESG"/>
    <dbReference type="OrthoDB" id="5415592at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054508">
        <property type="entry name" value="PIR1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051153">
        <property type="entry name" value="Yeast_CWMannoprotein_PIR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254:SF1">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22799">
        <property type="entry name" value="PIR1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208537" description="Cell wall mannoprotein PIR1-like C-terminal domain-containing protein" evidence="7">
        <location>
            <begin position="18"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall mannoprotein PIR1-like C-terminal" evidence="8">
        <location>
            <begin position="78"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="199"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ85373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="228" mass="23642" checksum="435B6F98B56DE1DC" modified="2006-03-21" version="1">MRFQLFALLAMVPLAIAQGVTDKVAPEGDAPAGCQPNADGRFEITVVPLAGKAKRDSLFANRATCSGGGTVVVQLADGVLTDDQGRTGYIASNFQFQFDDPPQSGALYTGGFSVCTNGSLALGSSATFWQCASGTFYNLYDRWSAAQCSPVDILVLPCGSGGENGNGQDATQTVVGTRIITTTLVVPLGDGQPQVITTTTLANSKHTPRPARQPTAPPSPKSPTAKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRN5</accession>
    <name>Q2GRN5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227296.1">
        <property type="nucleotide sequence ID" value="XM_001227295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRN5"/>
    <dbReference type="GeneID" id="4395620"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09369"/>
    <dbReference type="HOGENOM" id="CLU_1695271_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRN5"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="155" mass="16215" checksum="E09E7DC068D46496" modified="2006-03-21" version="1">MPPRRDPGVDAPARAVPRRGARWATAEVLGGVKDGAPAVLLALLPPLPPSSAFTPDTTASSTSSGHHDGASLGGASGAVDRGADGSGAKTSVLRGQVVEVLEVIFVRRHGSCANRQFRRRSTAFESVYSRDSRVVAAGSLQFPAVVRNWFEDLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRW6</accession>
    <name>Q2GRW6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_09288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227215.1">
        <property type="nucleotide sequence ID" value="XM_001227214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRW6"/>
    <dbReference type="GeneID" id="4395181"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09288"/>
    <dbReference type="HOGENOM" id="CLU_1189792_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRW6"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ85274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="233" mass="24760" checksum="176F42F2A23F1651" modified="2006-03-21" version="1">MSARMAEPLKALQVEMEAPASSVRVQGIAKMMEARAADDAGLFDGGPHPASNPIPNRIKFYNSHLGPDPSPSTRSLLASRGHRAAWADAENKVFKTGAATGTTYGKLSTIQADFRFTREFPDAALVSFVSTGLVVVDETPDNRFASHGDSGAVIRDGRAKMLGVVWAGVGPGREDYGDLALIGASHWSLRLSTITLCLPMGPFLRAMKAEVDKALPGQNARLFPLPNSFGPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GS41</accession>
    <name>Q2GS41_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_09213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227140.1">
        <property type="nucleotide sequence ID" value="XM_001227139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GS41"/>
    <dbReference type="GeneID" id="4394667"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09213"/>
    <dbReference type="HOGENOM" id="CLU_3406318_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GS41"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ85199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="30" mass="3366" checksum="69C2C37ECF6D305A" modified="2006-03-21" version="1">MVHCVRRPPADALAVVDGGRWRGRDHEVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSK9</accession>
    <name>Q2GSK9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226972.1">
        <property type="nucleotide sequence ID" value="XM_001226971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSK9"/>
    <dbReference type="GeneID" id="4394722"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09045"/>
    <dbReference type="HOGENOM" id="CLU_1309974_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSK9"/>
    <dbReference type="OrthoDB" id="10371141at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="210" mass="22831" checksum="E5638528FFB15EA4" modified="2006-03-21" version="1">MAAPGTGPAMVYQPLGSAALGHGSDDEDNERRWMVKSDLITVLRILVTLLAFADIVTWLSLGLASGTLVVAFIALFLVVGWNLTLVLPRSSFTRSLPAVVCQIGDCVCGFGGDHNQDDRPRKPKSRKQRRAKLIFIALVDLALGLIIVIFMWALELVLAILSLVACFWTLGLELGAVLRSIDEPEKYTRIQLAPDTEDRKTAGRTVSVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSL7</accession>
    <name>Q2GSL7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_09037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226964.1">
        <property type="nucleotide sequence ID" value="XM_001226963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSL7"/>
    <dbReference type="GeneID" id="4394862"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09037"/>
    <dbReference type="HOGENOM" id="CLU_2133229_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSL7"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ85023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="113" mass="12181" checksum="F0B715C2604EB348" modified="2006-03-21" version="1">MITNNQLVDAINHALLPCSLWCVMGGTRANYTRAHPRYLDRLQHCDTSRHEVLEVASSDYIGPLPPEVMSCLGPTAVPEEPAETQRGPCVAAKAAQSKPLLFAPGTCIERGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSX0</accession>
    <name>Q2GSX0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chalcone/stilbene synthase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_08934</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226861.1">
        <property type="nucleotide sequence ID" value="XM_001226860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSX0"/>
    <dbReference type="GeneID" id="4394912"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08934"/>
    <dbReference type="eggNOG" id="ENOG502S43A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034992_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GSX0"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001099">
        <property type="entry name" value="Chalcone/stilbene_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011141">
        <property type="entry name" value="Polyketide_synthase_type-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877:SF46">
        <property type="entry name" value="TYPE III POLYKETIDE SYNTHASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00195">
        <property type="entry name" value="Chal_sti_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Chalcone/stilbene synthase N-terminal" evidence="3">
        <location>
            <begin position="67"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ84920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="321" mass="33553" checksum="C5BB5419FC550C8D" modified="2006-03-21" version="1">MATQNEFEDLGLSILGLGAQYPPYDLKPESLEILSKRFYPESPAMSKVLAINRYTGIDQRSSIGTPDHPLVNQPNPPTITEINDIFMKEGVPLAVSAARKALAEAHVEAAQVTHMVSTTCTNSANPGYDHFVATELGLSPNTEKVLLHGVGCSGGLAALRTAANLCLGHTMRRQPARILVVALEISTTLVRSELDSSATILSVLDRLRRKDMDALAPAPRAGGGGGGGPKEYVVGCAFGPGITVEMCMLKRNLVGGSVASRGGMETPPETESEGGGGSDVDERSEQGEVASVEGARGGVDVGVGEDGEAFINEALEGVELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GT43</accession>
    <name>Q2GT43_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226788.1">
        <property type="nucleotide sequence ID" value="XM_001226787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GT43"/>
    <dbReference type="STRING" id="306901.Q2GT43"/>
    <dbReference type="GeneID" id="4395788"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08861"/>
    <dbReference type="eggNOG" id="ENOG502SK85">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1120052_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GT43"/>
    <dbReference type="OMA" id="YYMQARI"/>
    <dbReference type="OrthoDB" id="5398854at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="248" mass="27155" checksum="F2000C15AE993D93" modified="2006-03-21" version="1">MAGAYSPYGSTPAQEYIYDEKKFPSPSPTPSPRGPSYYYGATPQRPATRAHFRNGSTSGINNSNTGYASPRGPSFSPRYTSDGQYATVNVSVSRPRKPSFSGPPRPSRERRSSFSYHPASVSHGESDEDEFIDLGGQTFVLPGRSRPRPYKDHFTVNAGGHGTDYGYYAQGGPIFDREAGFASARFEPDRRPPPPAGHSRRSSTSMPQRPQTARPSASMHKKQRPRSPRLARPLPKMPSGTGFPLGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTB2</accession>
    <name>Q2GTB2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_08792</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226719.1">
        <property type="nucleotide sequence ID" value="XM_001226718.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2GTB2">
        <property type="interactions" value="435"/>
    </dbReference>
    <dbReference type="GeneID" id="4395429"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08792"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001995_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTB2"/>
    <dbReference type="OMA" id="CTVRRMD"/>
    <dbReference type="OrthoDB" id="4590285at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF440">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="5">
        <location>
            <begin position="479"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="237"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="323"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="797"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="852"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="819"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ84778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1460" mass="165719" checksum="63870BE684A49C7B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTF8</accession>
    <name>Q2GTF8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_08746</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226673.1">
        <property type="nucleotide sequence ID" value="XM_001226672.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4395572"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08746"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_31_0_1"/>
    <dbReference type="InParanoid" id="Q2GTF8"/>
    <dbReference type="OMA" id="IINHCTG"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF13">
        <property type="entry name" value="POLYKETIDE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="99"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="960"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2133"/>
            <end position="2210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="45"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="960"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1119"/>
            <end position="1279"/>
        </location>
    </feature>
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        <location>
            <begin position="45"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ84732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="2222" mass="240621" checksum="4FA6782D56261522" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTQ8</accession>
    <name>Q2GTQ8_CHAGB</name>
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        <recommendedName>
            <fullName evidence="13">Nucleoporin Nup133/Nup155-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_08646</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EAQ84632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001226572.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2GTQ8">
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    </dbReference>
    <dbReference type="STRING" id="306901.Q2GTQ8"/>
    <dbReference type="GeneID" id="4395342"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08646"/>
    <dbReference type="eggNOG" id="KOG4121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002493_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTQ8"/>
    <dbReference type="OMA" id="HVATLLW"/>
    <dbReference type="OrthoDB" id="103454at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Nuclear pore complex subunit Nup133, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="10">
        <location>
            <begin position="106"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="9">
        <location>
            <begin position="697"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1389"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="56"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ84632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1419" mass="157748" checksum="3172D1273B3F400B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU11</accession>
    <name>Q2GU11_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226470.1">
        <property type="nucleotide sequence ID" value="XM_001226469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GU11"/>
    <dbReference type="STRING" id="306901.Q2GU11"/>
    <dbReference type="GeneID" id="4395413"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08543"/>
    <dbReference type="eggNOG" id="ENOG502SHRF">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016969_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GU11"/>
    <dbReference type="OMA" id="SKLLVHW"/>
    <dbReference type="OrthoDB" id="4582033at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619:SF3">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="429"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="808" mass="90846" checksum="4245EFCF9DD1BE2F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU66</accession>
    <name>Q2GU66_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7143 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08488</name>
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    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226415.1">
        <property type="nucleotide sequence ID" value="XM_001226414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GU66"/>
    <dbReference type="GeneID" id="4394958"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08488"/>
    <dbReference type="eggNOG" id="ENOG502S5W9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120582_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GU66"/>
    <dbReference type="OMA" id="RQNPCFI"/>
    <dbReference type="OrthoDB" id="2497581at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055567">
        <property type="entry name" value="DUF7143"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37592">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37592:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23631">
        <property type="entry name" value="DUF7143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208615" description="DUF7143 domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7143" evidence="2">
        <location>
            <begin position="30"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="189" mass="20312" checksum="FBBF6685BB8DB17D" modified="2006-03-21" version="1">MKLFAVIYFGAGFALSAPLISERQANSCFLVGNQVLPKEVADIVTNLQERITCDNSRTTLSGVPDVFSGGVSFSSVNFASSAQTPLQFALDKFATPTPLRNADLATFQKQLDVYLATEAGIRSVGGNLGIKVPKFFLQFQVSRIQTAQGNPPTAPGAQVDHLLQKVLKNAPRESKQLRDQVTALAKTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUG8</accession>
    <name>Q2GUG8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_08386</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226313.1">
        <property type="nucleotide sequence ID" value="XM_001226312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUG8"/>
    <dbReference type="GeneID" id="4394704"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08386"/>
    <dbReference type="eggNOG" id="ENOG502SK11">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032923_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GUG8"/>
    <dbReference type="OMA" id="REVTKQC"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ84372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="399" mass="44236" checksum="8A5D65E88125BCA1" modified="2006-03-21" version="1">MADPLSITASVLAVVTAAIQSTKSLSATVKRYKDRDQTLNRLQAELEDLINILTSLEAAAGSDRSMSALLEGPVNRCSQVCVEFEKAMVKFTGKTKTGRRDWARMEFMRGDIRDFMDTLASYKSTIMVGLGTITIEMIQDTAYNLEIRLQRVEESLFNDSTSAEATIDLQDEREMTRQCLRICQDAQSYLKSLQDGQASQRAETTSSSSLTSNVQVQSLFDAEVMTIQAINESRRKFLETINQLQDRLASATSTQGAEREKQMSQLREDINISKQCLEVCQTATAQVHHHRKILTVGEVIADDDTDQVVVTTLADLFDVRKVLAKSRSSQLVGSMTEETLQQVSRDRYRSRFGSASGDLGPVQTGTPSPSSNSGFRESSRRRPSPNEARKRATDGESGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUI1</accession>
    <name>Q2GUI1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Ribonuclease H</fullName>
            <shortName evidence="10">RNase H</shortName>
            <ecNumber evidence="4 10">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_08373</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="4 10"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226300.1">
        <property type="nucleotide sequence ID" value="XM_001226299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUI1"/>
    <dbReference type="FunCoup" id="Q2GUI1">
        <property type="interactions" value="219"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GUI1"/>
    <dbReference type="GeneID" id="4394739"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08373"/>
    <dbReference type="eggNOG" id="KOG3752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030894_0_5_1"/>
    <dbReference type="InParanoid" id="Q2GUI1"/>
    <dbReference type="OMA" id="ELWYGLY"/>
    <dbReference type="OrthoDB" id="407198at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09280">
        <property type="entry name" value="RNase_HI_eukaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000090">
        <property type="entry name" value="Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.970.10:FF:000001">
        <property type="entry name" value="Ribonuclease H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017067">
        <property type="entry name" value="RNase_H1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036852">
        <property type="entry name" value="Ribonuclease_H1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="11">
        <location>
            <begin position="162"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ84359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="312" mass="34384" checksum="C2775C5B8B2B8D29" modified="2006-03-21" version="1">MPVAKKRKMDAAEQKYYAVRAGFKPGVYTSWTICQQQITGFKGAQFKSFLTYEDASAFAAGREPASAVDDTKPPRFYGVAVGRKPGVYTEWPAAQEAIIGWKGPKYKKFETRAEAEAFVRSFSGSAKAIAPTVAGSDQDDADGIEEPTAKRRKTTKKTIKAQNGLVIVYTDGSSLGNGRVGATAGVGVYFGANDPRNVSERLEGETQTNQRAELTAILRALEIIDLEQDLEIRTDSKYSIQCVTEWYINWERNGWKTRSGPVKNQDLVQLVRDKLEEREAKGGRTQFIWVKGHDTDQGNIAADQLAVAGARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVC8</accession>
    <name>Q2GVC8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">xanthine dehydrogenase</fullName>
            <ecNumber evidence="4">1.17.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CHGG_08076</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hypoxanthine + NAD(+) + H2O = xanthine + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24670"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>xanthine + NAD(+) + H2O = urate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="20">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="20">Binds 2 [2Fe-2S] clusters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.4" evidence="4"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225732.1">
        <property type="nucleotide sequence ID" value="XM_001225731.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GVC8"/>
    <dbReference type="GeneID" id="4394512"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08076"/>
    <dbReference type="eggNOG" id="KOG0430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001681_1_2_1"/>
    <dbReference type="InParanoid" id="Q2GVC8"/>
    <dbReference type="OMA" id="PHPTQER"/>
    <dbReference type="OrthoDB" id="8300278at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004854">
        <property type="term" value="F:xanthine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000015">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000003">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.50:FF:000001">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000002">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014307">
        <property type="entry name" value="Xanthine_DH_ssu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02963">
        <property type="entry name" value="xanthine_xdhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444:SF3">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000127">
        <property type="entry name" value="Xanthine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 20" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9 19" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 20" id="KW-0408">Iron</keyword>
    <keyword evidence="12 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 20" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="21">
        <location>
            <begin position="24"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="22">
        <location>
            <begin position="261"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="1291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="790"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="821"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="825"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="903"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="935"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="937"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1033"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="1102"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EAQ86823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1371" mass="150599" checksum="96A00D8B12DF76E7" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVJ4</accession>
    <name>Q2GVJ4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="11">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="11">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="11">PHB:PPT</shortName>
            <shortName evidence="11">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_08010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Mitochondrion inner membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
            <orientation evidence="2 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="11"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225666.1">
        <property type="nucleotide sequence ID" value="XM_001225665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVJ4"/>
    <dbReference type="FunCoup" id="Q2GVJ4">
        <property type="interactions" value="314"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GVJ4"/>
    <dbReference type="GeneID" id="4393483"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08010"/>
    <dbReference type="eggNOG" id="KOG1381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034879_2_1_1"/>
    <dbReference type="InParanoid" id="Q2GVJ4"/>
    <dbReference type="OMA" id="WCMIYDT"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="UniPathway" id="UPA00213"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000003">
        <property type="entry name" value="4-hydroxybenzoate polyprenyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ86757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="409" mass="43980" checksum="F6C91200628790AD" modified="2006-03-21" version="1">MSTCRILPRLPLRPPFSQTTNSYKPCHPRLSIPTSRAVSAPRRLAIETHASSSTRSLIAYHTTTKLLSTATTTSPPTPTAPTTTELPSYTPPQTGLLSVLPQSWVPYAELIRLDKPTGSYYLYFPCIFSTLLAAPLAVPTTPPLTVLGTSLLFLAGAIVMRGAGCTINDLWDRNLDPHVARTRLRPIARGAVTPFRAVIFTGAQLLAGLAVLLQFPLSCFFYATPSLLLVATYPLAKRVTYYPQFVLGLTFSWGAIMGFPALGVDLLHNGAAQAAAACLYASNVAWTVLYDMIYAHMDIKDDAKAGIKSIALKHDRETKQVLSGLAVAQVALLAGAGIATGAGPAFFVGSCGGALVTLGIMIKRVNLKSVKDCWWWFVNGCWITGGAVTLGLTADYLVRYAERDDEKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVQ0</accession>
    <name>Q2GVQ0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alanine--glyoxylate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_07954</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.44" evidence="3"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225610.1">
        <property type="nucleotide sequence ID" value="XM_001225609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVQ0"/>
    <dbReference type="FunCoup" id="Q2GVQ0">
        <property type="interactions" value="1153"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GVQ0"/>
    <dbReference type="GeneID" id="4394241"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07954"/>
    <dbReference type="eggNOG" id="KOG2862">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027686_5_2_1"/>
    <dbReference type="InParanoid" id="Q2GVQ0"/>
    <dbReference type="OMA" id="YEWDTPA"/>
    <dbReference type="OrthoDB" id="7403325at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004760">
        <property type="term" value="F:L-serine-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019265">
        <property type="term" value="P:glycine biosynthetic process, by transamination of glyoxylate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000049">
        <property type="entry name" value="Alanine-glyoxylate aminotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000027">
        <property type="entry name" value="Serine--pyruvate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152:SF24">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152">
        <property type="entry name" value="AMINOTRANSFERASE CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="9">
        <location>
            <begin position="32"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ86701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="385" mass="41045" checksum="0AF4857BBB1604E3" modified="2006-03-21" version="1">MSSQPAHPTLLIPGPIEFDDAVLQSMSHYSESHVGPGFVATFGETLSMLRKLFQTTDPSAQPFVISGSGTLGWDLVAANLIESGEDVLVLGTGYFSDGFADCLRVYGANVTELKAPVGTKPQLPEIEKALSEKRYKAITVTHVDTSTGVLSELKELSALVHKVSPDTLIIVDGVCSVACEEIDFDAWGLDGVVTASQKAIGCPAGLSISMFSGRAMKAVQARKTPPAAYFASMKNWAPIMQNYEAKKPSYFATPSPQLVHALHTALSQILSKPISERFAAHKAGSDRIKKVVTGLGLKQVAGNPAEQAHGMTAIYLPEGVKGTDLLPILGKKGVVFAGGIHKEIATKYIRFGHMGVSLLDPKRTDVDHALKSLEEGLAECGYKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVU8</accession>
    <name>Q2GVU8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225562.1">
        <property type="nucleotide sequence ID" value="XM_001225561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVU8"/>
    <dbReference type="GeneID" id="4394368"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07906"/>
    <dbReference type="eggNOG" id="ENOG502T4JK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_465389_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GVU8"/>
    <dbReference type="OrthoDB" id="4570123at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="586" mass="65486" checksum="A7A272F2E4A483B8" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVY7</accession>
    <name>Q2GVY7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225523.1">
        <property type="nucleotide sequence ID" value="XM_001225522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVY7"/>
    <dbReference type="GeneID" id="4393723"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07867"/>
    <dbReference type="HOGENOM" id="CLU_2558108_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GVY7"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="82" mass="8567" checksum="E1F38D907A7589F8" modified="2006-03-21" version="1">MAVYAVKRQSRVVACALGTANEPNVTSPHLRHGCSGRPTASSPGGSGGKGKPGSRHRRCRPALDSVGSIDLPPRAVTRLQHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWB6</accession>
    <name>Q2GWB6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear pore complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_07738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225394.1">
        <property type="nucleotide sequence ID" value="XM_001225393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWB6"/>
    <dbReference type="STRING" id="306901.Q2GWB6"/>
    <dbReference type="GeneID" id="4393386"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07738"/>
    <dbReference type="eggNOG" id="ENOG502S8U7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044363_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWB6"/>
    <dbReference type="OMA" id="QYATTFD"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012578">
        <property type="entry name" value="Nucl_pore_cmplx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28003">
        <property type="entry name" value="NUCLEOPORIN POM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28003:SF1">
        <property type="entry name" value="NUCLEOPORIN POM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08058">
        <property type="entry name" value="NPCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ86485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="29620" checksum="4A8E128A2B2466D4" modified="2006-03-21" version="1">MSSSIMTPVKATPVKQTTAPPAVSDSPGNWKHPRLAEITRRQSQNVFSEKNIRKMVYNAVALVGIGLVRQVVLPFVPSWLITPLWRQYSSWITATLILVPLINIVMALLPLYRPQDDLSDIPLTPAQRKLLGLPPSSRPETPNSVYSTPPRYSRTPSLAGSPASIKSYASSPLSNFASPSPGQYSSPRFGTSPSKLNAPQYSPSNVSPLRHKAIGGRTTSFGSTSPLNASTASSAFGEGPATPTPATGKRSTVGLNNKWLYEKGRRSSGNSWLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWS2</accession>
    <name>Q2GWS2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_07582</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DNA polymerase alpha subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225238.1">
        <property type="nucleotide sequence ID" value="XM_001225237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWS2"/>
    <dbReference type="FunCoup" id="Q2GWS2">
        <property type="interactions" value="374"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GWS2"/>
    <dbReference type="GeneID" id="4394637"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07582"/>
    <dbReference type="eggNOG" id="KOG1625">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014923_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GWS2"/>
    <dbReference type="OMA" id="PFLDIEH"/>
    <dbReference type="OrthoDB" id="336885at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.60:FF:000005">
        <property type="entry name" value="DNA polymerase alpha subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.60:FF:000008">
        <property type="entry name" value="DNA polymerase alpha subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054300">
        <property type="entry name" value="OB_DPOA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22062">
        <property type="entry name" value="OB_DPOA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018300">
        <property type="entry name" value="DNA_pol_alph_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha subunit B OB" evidence="8">
        <location>
            <begin position="215"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="7">
        <location>
            <begin position="362"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR018300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ86329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="657" mass="70734" checksum="F0E236E3B12214F8" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXV2</accession>
    <name>Q2GXV2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">valine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_07202</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="2"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224858.1">
        <property type="nucleotide sequence ID" value="XM_001224857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXV2"/>
    <dbReference type="STRING" id="306901.Q2GXV2"/>
    <dbReference type="GeneID" id="4393674"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07202"/>
    <dbReference type="eggNOG" id="KOG0432">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GXV2"/>
    <dbReference type="OrthoDB" id="629407at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000009">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000078">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="13">
        <location>
            <begin position="91"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="14">
        <location>
            <begin position="767"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="202"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="297"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ85949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="980" mass="108458" checksum="B9E25EF582A65DC0" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXW5</accession>
    <name>Q2GXW5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_07189</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224845.1">
        <property type="nucleotide sequence ID" value="XM_001224844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXW5"/>
    <dbReference type="FunCoup" id="Q2GXW5">
        <property type="interactions" value="601"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GXW5"/>
    <dbReference type="GeneID" id="4394613"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07189"/>
    <dbReference type="eggNOG" id="KOG2726">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036856_0_8_1"/>
    <dbReference type="InParanoid" id="Q2GXW5"/>
    <dbReference type="OMA" id="DHRVGFK"/>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000070">
        <property type="entry name" value="Related to MRF1-peptide chain release factor, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="5">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ85936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="400" mass="44400" checksum="88CF315A2DAC145F" modified="2006-03-21" version="1">METHTTLPSALLERARKLAIEHDQLSAALENDFDAKKAKRAGELSRVASAVKELEKAKAALVELQGLLESNDAEMRELARDDLEATNAQLAESSHNLSVALTPKHPFADMPCLLEIRPGPGGLEGRFFADSLFQMYKAYCSNKGYRTRIVQYEASDSDGSTGSEGEIPLQEAVLEVQEEGAYGLFRGEAGMHRVQRVPATEKSGRTHTSAVAVWVLPSFPENGTSDSEADWDKPESDFYIDPNEVRSETMRAGGAGGQHVNKTESAIRLTHIPTGTTVSMQDSRSQQRNREDAWRLLRSRLAQQRREAREEQARQLRSSVLANSQITRGDKIRTYQYQQDRCTDHRSGLNTHNLPDVLRGGETLEKVMDSVQNWLVNKDIEALIADEEAAAAPSKKKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYW7</accession>
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        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_107248_1_0_1"/>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="40S ribosomal protein S24"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="eRP_eS24_sf"/>
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        <property type="entry name" value="Ribosomal_eS24"/>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
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    <proteinExistence type="inferred from homology"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004383"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ85584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="136" mass="15567" checksum="0A5CAE5CF1DB491D" modified="2006-03-21" version="1">MADSDSPVTLRTRKFIRNPLLGRKQMVVDILHPNRANISKEELREKLAGMYKAQKDQVNVFGLRTQFGGGKTTGFALVYDSPEAMKKFEPHFRLVRVGMATKIEKASRQQRKQRKNRQKTLRGTAKVKGPKAKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZ23</accession>
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        </submittedName>
    </protein>
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    <organism evidence="5 6">
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001224436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZ23"/>
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        <property type="interactions" value="1038"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GZ23"/>
    <dbReference type="GeneID" id="4391809"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05223"/>
    <dbReference type="eggNOG" id="KOG1128">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004905_0_1_1"/>
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    <dbReference type="OMA" id="NNRYARA"/>
    <dbReference type="OrthoDB" id="1936594at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044244">
        <property type="entry name" value="TTC27/Emw1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <feature type="repeat" description="TPR" evidence="3">
        <location>
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            <end position="671"/>
        </location>
    </feature>
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        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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        <location>
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        </location>
    </feature>
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        <location>
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        <location>
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        <location>
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            <end position="736"/>
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    </feature>
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        <location>
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            <end position="832"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ88604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1005" mass="109299" checksum="915E29C80AB89F03" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZF5</accession>
    <name>Q2GZF5_CHAGB</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CHGG_05091</name>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001224304.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4392233"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05091"/>
    <dbReference type="eggNOG" id="ENOG502QZ1C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_258484_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZF5"/>
    <dbReference type="OMA" id="HTHANRG"/>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1159"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="761"/>
        </location>
    </feature>
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        <location>
            <begin position="776"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="794"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="880"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="923"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="951"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="961"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="979"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1031"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1066"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1166"/>
            <end position="1176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1339" mass="147336" checksum="027C8FCC6E787224" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZU6</accession>
    <name>Q2GZU6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kelch repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_04950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2005-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Giovannoni S.J."/>
                <person name="Cho J.-C."/>
                <person name="Ferriera S."/>
                <person name="Johnson J."/>
                <person name="Kravitz S."/>
                <person name="Halpern A."/>
                <person name="Remington K."/>
                <person name="Beeson K."/>
                <person name="Tran B."/>
                <person name="Rogers Y.-H."/>
                <person name="Friedman R."/>
                <person name="Venter J.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 148.51</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2006-02" db="EMBL/GenBank/DDBJ databases">
            <title>Annotation of the Chaetomium globosum CBS 148.51 Genome.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Birren B."/>
                <person name="Lander E."/>
                <person name="Galagan J."/>
                <person name="Devon K."/>
                <person name="Nusbaum C."/>
                <person name="Ma L.-J."/>
                <person name="Jaffe D."/>
                <person name="Butler J."/>
                <person name="Alvarez P."/>
                <person name="Gnerre S."/>
                <person name="Grabherr M."/>
                <person name="Kleber M."/>
                <person name="Mauceli E."/>
                <person name="Brockman W."/>
                <person name="Rounsley S."/>
                <person name="Young S."/>
                <person name="LaButti K."/>
                <person name="Pushparaj V."/>
                <person name="DeCaprio D."/>
                <person name="Crawford M."/>
                <person name="Koehrsen M."/>
                <person name="Engels R."/>
                <person name="Montgomery P."/>
                <person name="Pearson M."/>
                <person name="Howarth C."/>
                <person name="Kodira C."/>
                <person name="Yandava C."/>
                <person name="Zeng Q."/>
                <person name="Alvarado L."/>
                <person name="Oleary S."/>
                <person name="Untereiner W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 148.51</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001224163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZU6"/>
    <dbReference type="GeneID" id="4392762"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04950"/>
    <dbReference type="eggNOG" id="ENOG502SMKA">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012508_3_1_1"/>
    <dbReference type="InParanoid" id="Q2GZU6"/>
    <dbReference type="OMA" id="CYTMPAF"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cell periphery"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
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        <property type="entry name" value="Kelch-typ_b-propeller"/>
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        <property type="entry name" value="CHITIN-BINDING TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        </location>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ88331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="609" mass="64722" checksum="55504E33F2524844" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H165</accession>
    <name>Q2H165_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04481</name>
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    <organism evidence="2 3">
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        <name type="common">Soil fungus</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001223694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H165"/>
    <dbReference type="STRING" id="306901.Q2H165"/>
    <dbReference type="GeneID" id="4391796"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04481"/>
    <dbReference type="eggNOG" id="ENOG502RJIP">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_879993_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H165"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
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            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="316" mass="33463" checksum="9D834DAADD68AA29" modified="2006-03-21" version="1">MARPAAATPGSAASANATGPYSHLTEHQMQLMNEELKAAEEKYQPRFAEANQIADENARRARVEGLRNSFGTKQSMIRKKYGVRLRERRTKAEIFAERERLGLKKAEKEKEREKARGPAGTQTHNASPLAHPDFASRAAAGSGWTAANTPRTSSWEGPSAKRQRTDEDGGYQTPYKSLADETPTHKTLSASLLGNGSAGSSAVAATHDPTTPQSSRPAAVYEQAGARVEIHEPSKASNSLGGPDPSGATSESATPDGSEPGANDHGPNRGFQVPTAVVIDDDSSSDDDGDEDIPSTLPAHVRKGLASGSTSRLQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H192</accession>
    <name>Q2H192_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="9 10">
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        <name type="common">Soil fungus</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001223667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H192"/>
    <dbReference type="STRING" id="306901.Q2H192"/>
    <dbReference type="GeneID" id="4391649"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04454"/>
    <dbReference type="eggNOG" id="KOG0409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_344833_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H192"/>
    <dbReference type="OMA" id="AGCNCAR"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19473">
        <property type="entry name" value="SET_SUV39H_DIM5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
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        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060:SF17">
        <property type="entry name" value="L-THREONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pre-SET" evidence="7">
        <location>
            <begin position="562"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="651"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="8">
        <location>
            <begin position="804"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ87835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="820" mass="89227" checksum="74530760CC002BF9" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1A6</accession>
    <name>Q2H1A6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription initiation factor IIB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General transcription factor TFIIB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_04440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223654.1">
        <property type="nucleotide sequence ID" value="XM_001223653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1A6"/>
    <dbReference type="FunCoup" id="Q2H1A6">
        <property type="interactions" value="728"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H1A6"/>
    <dbReference type="GeneID" id="4391984"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04440"/>
    <dbReference type="eggNOG" id="KOG1597">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043736_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H1A6"/>
    <dbReference type="OMA" id="DHDQRMK"/>
    <dbReference type="OrthoDB" id="25790at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001113">
        <property type="term" value="P:transcription open complex formation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001174">
        <property type="term" value="P:transcriptional start site selection at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd20551">
        <property type="entry name" value="CYCLIN_TFIIB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000036">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="8">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ87821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="353" mass="38758" checksum="DDEFC9569E8356DC" modified="2006-03-21" version="1">MASAFSPFEEVGKQAEFREDLNRILICPECKEDPPRLVEEYSSGDMVCETCGLVLDRIIDTRSEWRTFSGDDNGNDDPSRVGDAPNLMIDGDQLQTAIAFDGKGAKNLAHLQNKINQDKGTKVLLQAYRDIQALTDSINAGTQVANTAKHIFKMVDDNKALKGKSQEAIVAGCIFIACRQTNVPRTFREVYGLTKVSKKEIGRVFKQLESFLQKMGGEDKVAKATGYSQQYTAKGSTTADELCIRYCSNLGFRNAVRVESVARRLAEKSSEVSDLAGRSPLSVAAACIYMASHLVGEPRSTKQISVVSSVSDGTVKTAYRYLYAAKDTILTKEVFSEEMFGDVLANIDKVPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1I3</accession>
    <name>Q2H1I3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223577.1">
        <property type="nucleotide sequence ID" value="XM_001223576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1I3"/>
    <dbReference type="STRING" id="306901.Q2H1I3"/>
    <dbReference type="GeneID" id="4392114"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04363"/>
    <dbReference type="eggNOG" id="ENOG502SJF8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1089901_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H1I3"/>
    <dbReference type="OrthoDB" id="4571872at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="71"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="255" mass="28204" checksum="F97DDBC84E4C1595" modified="2006-03-21" version="1">MAAPKPQPPLVPQLSLSSGGGIMADLPEHQKDVVIVELKNHLARLKTLKSNRMGGPSGIVIPPYRVLCETERDDWSQLRPSDHAEYVFCHNDCSQHNIIVNPTTLKIAAIVDWEYAGFYPEYFEFPFYLRKGPSVALGEEEDDTYAMLHFLNSQLSWEVWTPATTPCALSIVTDVLHSPGPGATHSNESNLSTVSVINLHRVHPIPPRAAGQTSQSRNWAFKDSGEGFHAGPGFYHLSQKFLIMKTALTHLPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1I5</accession>
    <name>Q2H1I5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pectate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_04361</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223575.1">
        <property type="nucleotide sequence ID" value="XM_001223574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1I5"/>
    <dbReference type="STRING" id="306901.Q2H1I5"/>
    <dbReference type="GeneID" id="4392706"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04361"/>
    <dbReference type="eggNOG" id="ENOG502S66G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021894_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H1I5"/>
    <dbReference type="OMA" id="WANFGSR"/>
    <dbReference type="OrthoDB" id="1637350at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF18">
        <property type="entry name" value="PECTATE LYASE 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012768282" description="Pectate lyase domain-containing protein" evidence="5">
        <location>
            <begin position="16"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="6">
        <location>
            <begin position="54"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ87742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="330" mass="34604" checksum="60682F6995B9ABC6" modified="2006-03-21" version="1">MKLLAAASLLALATASPTPTQPQAGTPRMAKRADVSEAANLGYATLNGGTKGGAGGTVTTVSTLPQFTEAVNEKNSEPVVVFVKGVISGAAKVRVGSNKSIIGLPGSGFKGVGLHFRKQSNLIVRNIVSSFVEADQGDALKIEESTNVWVDHCEFYSALVADKDFYDGLVDSSHGSDFITISHTYFHDHWKASLAGHSDSNGGEDTGKLHVTYANNHWKNINSRGPLLRFGTGHIYNSYFENMSTAINTRMGAQVLVQSNVFSNVTAPVTSRDSKEVGYATVIDTDLGGGLNDAPKGNMATDAVGYQYSLLGSGAVAGKVPGEAGAILTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1K1</accession>
    <name>Q2H1K1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_04345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223559.1">
        <property type="nucleotide sequence ID" value="XM_001223558.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4392126"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04345"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_236592_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H1K1"/>
    <dbReference type="OMA" id="SIDICIS"/>
    <dbReference type="OrthoDB" id="3798483at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019825">
        <property type="entry name" value="Lectin_legB_Mn/Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00307">
        <property type="entry name" value="LECTIN_LEGUME_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="5">
        <location>
            <begin position="283"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="4">
        <location>
            <begin position="553"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="1187"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1557"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1572"/>
            <end position="1593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ87726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1610" mass="180330" checksum="5238DC30C43557C3" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1K9</accession>
    <name>Q2H1K9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_04337</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223551.1">
        <property type="nucleotide sequence ID" value="XM_001223550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1K9"/>
    <dbReference type="FunCoup" id="Q2H1K9">
        <property type="interactions" value="106"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H1K9"/>
    <dbReference type="GeneID" id="4391698"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04337"/>
    <dbReference type="eggNOG" id="ENOG502QU8E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017709_1_1_1"/>
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        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Glucose_rcpt_Git3-like_N"/>
    </dbReference>
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        <property type="entry name" value="GPR1/2/3_C"/>
    </dbReference>
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        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR GPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Git3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
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        <location>
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            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="143"/>
        </location>
    </feature>
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        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
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            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="326"/>
        </location>
    </feature>
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        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
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        <location>
            <begin position="44"/>
            <end position="227"/>
        </location>
    </feature>
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            <begin position="293"/>
            <end position="376"/>
        </location>
    </feature>
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        <location>
            <begin position="492"/>
            <end position="519"/>
        </location>
    </feature>
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        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF11710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ87718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="58051" checksum="CCE0D824D6E1F5F0" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1M2</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="GeneID" id="4391952"/>
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    <dbReference type="HOGENOM" id="CLU_773864_0_0_1"/>
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    <dbReference type="OrthoDB" id="4581101at2759"/>
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    </dbReference>
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        <location>
            <begin position="28"/>
            <end position="121"/>
        </location>
    </feature>
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        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
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            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
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            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="358" mass="39617" checksum="1103CA53CC2689F3" modified="2006-03-21" version="1">MTSKPGRIPLITWMRFIFLFLRGRRNKSIRPSTNDKQETKVKGESLFRWLKSGKRSQTGGEAASPEDAPAPPRPSDGLIAEPRGPPSLSADESSTSTKGPSSFKQCNLDAAPKTAMRRPRLRRIAGVADLKVLARQNMPTLDGDRKETRREPILCPPSVRHGLAPRLHLDGDGEQRLRWRRDSTSRKRHQLTLKQPHQSMAIRCHSVNLGFLERSLHTGGRSGLRNIHTSQSGIRAANPTPQPLTEALALQQGEGLKPTNGDSNGIERRDYGFKSSLTQMQLPLVIEAYKGVLKWRKRETVLSQVTRPAVETDAIRSSRSSPDAAANATREAVPTLEHWLATLSVTYDGLVKEGGESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1T6</accession>
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        <recommendedName>
            <fullName evidence="5">Phytocyanin domain-containing protein</fullName>
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        <lineage>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="306901.Q2H1T6"/>
    <dbReference type="GeneID" id="4391806"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04260"/>
    <dbReference type="eggNOG" id="ENOG502S40X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1042073_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H1T6"/>
    <dbReference type="OMA" id="CEAHCTS"/>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
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        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF17">
        <property type="entry name" value="CUPREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208703" description="Phytocyanin domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="267"/>
        </location>
    </feature>
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        <location>
            <begin position="149"/>
            <end position="244"/>
        </location>
    </feature>
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            <end position="161"/>
        </location>
    </feature>
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        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
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        <location>
            <begin position="187"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="25699" checksum="009131B407BA9583" modified="2006-03-21" version="1">MHPTAVLLTIAGLSAATTIPVSVGKNGLTFEPNMIHAQEGDVIEFRFWPRNHSVVAGHFNEACRPASENGFFSGFFPTQPDTVNTRCPATARRKKGQDAKNGMVAVINPAGVGRLSLAAYAALARASAGNATSPSGGVFGGVVAPNQSQGGGGGGGGGGGSVSATGGSSVTGGSGSATATSGGGSASGASSSTVEDSETETQTQTQTESTAESETTAAATTTTGGGGGATVTSATEAPTGTETGNAAAGVVAPVAGLVAVVMGAFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2D6</accession>
    <name>Q2H2D6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_04060</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001223273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2D6"/>
    <dbReference type="GeneID" id="4392872"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04060"/>
    <dbReference type="HOGENOM" id="CLU_2222966_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2D6"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ87441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="106" mass="12025" checksum="3CDF9086FC62CC4D" modified="2006-03-21" version="1">MYFYRLFIRFSLRLTEFLDLRPTNSTYTHDVKKEYGCISAPCRLRTALCDVTKHGPSAARHRAASSPYAAALSHLVPESRNGRVVRSPMGKPRRSLPSEAKINFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2J9</accession>
    <name>Q2H2J9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine-specific methyltransferase SAM-dependent domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_03997</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223211.1">
        <property type="nucleotide sequence ID" value="XM_001223210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2J9"/>
    <dbReference type="GeneID" id="4392059"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03997"/>
    <dbReference type="eggNOG" id="ENOG502SQAU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_373373_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2J9"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017805">
        <property type="entry name" value="SAM_MeTrfase_EasF-type_put"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03439">
        <property type="entry name" value="methyl_EasF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF2">
        <property type="entry name" value="HISTIDINE-SPECIFIC METHYLTRANSFERASE SAM-DEPENDENT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="4">
        <location>
            <begin position="2"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ87378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="744" mass="81553" checksum="BBC5A79B362C0ACC" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H349</accession>
    <name>Q2H349_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223011.1">
        <property type="nucleotide sequence ID" value="XM_001223010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H349"/>
    <dbReference type="GeneID" id="4393045"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03797"/>
    <dbReference type="HOGENOM" id="CLU_2249822_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H349"/>
    <dbReference type="OrthoDB" id="10313413at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208476" description="Hydrophobin" evidence="1">
        <location>
            <begin position="18"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="10407" checksum="29835FC3BDA5B1F7" modified="2006-03-21" version="1">MKATTAIFLTIATLATAAPSPNAATNLGLLTTRQGCSYACVCQTDGEGEGPSPDTTRCCTGGTPVNEGVACTEMNFAAAVNFVGCCTLGHICTVASGCDPIPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3B6</accession>
    <name>Q2H3B6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_03730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222944.1">
        <property type="nucleotide sequence ID" value="XM_001222943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3B6"/>
    <dbReference type="STRING" id="306901.Q2H3B6"/>
    <dbReference type="GeneID" id="4391730"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03730"/>
    <dbReference type="eggNOG" id="ENOG502S3ZI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054794_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H3B6"/>
    <dbReference type="OMA" id="YYDFVGH"/>
    <dbReference type="OrthoDB" id="539398at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39336:SF3">
        <property type="entry name" value="PYRIDOXAMINE PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39336">
        <property type="entry name" value="PYRIDOXAMINE PHOSPHATE OXIDASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ87111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="266" mass="29841" checksum="EB8A2BBF56C99692" modified="2006-03-21" version="1">MGQFFETIPEYLMKWILEQKMFWVATSPLSASGHVNVSPKGGLYFGLLDDKTFWYMDLSGSGSETIAHLYEPDNGRITVMFNSFEGPPRIVRLFGHGSVLERGGVHEGGGEAFDDFVKKHDLQVLPSSRSIIIVKVHQVASSCGYSVPYYEFKDFRNTLNETFTKKAEKFEQGKSQESRERYWAFKNAYSVDGLPGMKIGYKTGKQEGIAPIQKMVGPMAPRTYHNSRRFGPWHLVLVAVLSAVCGAFFQRLLLTTLQGILDSSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3G8</accession>
    <name>Q2H3G8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_06797</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222892.1">
        <property type="nucleotide sequence ID" value="XM_001222891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3G8"/>
    <dbReference type="FunCoup" id="Q2H3G8">
        <property type="interactions" value="203"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H3G8"/>
    <dbReference type="GeneID" id="4391374"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06797"/>
    <dbReference type="eggNOG" id="KOG0223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_1_7_1"/>
    <dbReference type="InParanoid" id="Q2H3G8"/>
    <dbReference type="OMA" id="FKKKMFW"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="267"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ90178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="33007" checksum="88C145D5BE41EE7D" modified="2006-03-21" version="1">MSPSSSRPHRMLSFASEAGQNGSPTRLPMLTKPLTKHNNIVAALGEFVGTFLFLFFAFAGTQVANTPAPAPANGRDTPLPNTSNLMFIALAFGLSLMANVWAFYRVALALFLVGGLSLVRLLVVVIAQFLGGIAAAAVVSALFPGPMAVATTLGAGASISQGLFIEMFLTAQLVFVIIMLAAEKHKSTFLAPIGIGITFFLAELVGVYFTGGSLNPARSLGPAVVNHSFPGYFWIYWLGPLLGSLLACGFYVLLKYLRWKECNPGQDWDDAEKRKSEKHLTGKEASNHSESPNNGTAVGEDHRADAETGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3P8</accession>
    <name>Q2H3P8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SVP1-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_06717</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222812.1">
        <property type="nucleotide sequence ID" value="XM_001222811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3P8"/>
    <dbReference type="FunCoup" id="Q2H3P8">
        <property type="interactions" value="348"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H3P8"/>
    <dbReference type="GeneID" id="4391352"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06717"/>
    <dbReference type="eggNOG" id="KOG2111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025895_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3P8"/>
    <dbReference type="OMA" id="GGPQCMC"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ90098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="42070" checksum="CBCE7843D58794B4" modified="2006-03-21" version="1">MNTRTPLESPSSTVVLSISFNDDCSCFAVGLNTGFCKTCARRTTRVFNAGVGLVQMMGKANYIGLVGGGRQPKFAANKASPCRFYAALEISALTPVRGVQLSKEHIVVVLQNSVRVYKFAKPPNLQSAYETANNPWGLCCLSPKRIAFPGRTVGHVQLVEIATGNVSIIPAHSSAIKAVQLSPDGELLATASEKGTLIRVFATSNCARLVELRRGIDPATIFSLAFNPSGTMLACTSDKSTLHVFDVPHPKRASWQQQQQEQQQLQNGGVSGATSGSTSESNGGDGAGKWGILSKIPLMPRMFSDVYSFASAPFEVDDEETTNEGMTSGLPVSETTTLGTSKPPKGVLGWVGENTVLVVGAGKDARWEKFGIQEGGDGKRYCVREGWKRYLVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3T2</accession>
    <name>Q2H3T2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">BCS1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_06683</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222778.1">
        <property type="nucleotide sequence ID" value="XM_001222777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3T2"/>
    <dbReference type="STRING" id="306901.Q2H3T2"/>
    <dbReference type="GeneID" id="4390873"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06683"/>
    <dbReference type="eggNOG" id="KOG0743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010189_4_4_1"/>
    <dbReference type="InParanoid" id="Q2H3T2"/>
    <dbReference type="OMA" id="FEPTRGN"/>
    <dbReference type="OrthoDB" id="4574514at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="BCS1 N-terminal" evidence="11">
        <location>
            <begin position="47"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ90064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="416" mass="47504" checksum="7A8747BAF4B27591" modified="2006-03-21" version="1">MANNTTFSTPLIATQVSVLDFFVPGSSSILAAIELVLGTNSYIRPLMLCMFLAFLGRRVFRFVWDVAETYFVSTVHVQYGSEVYDMVNLWATSQPFARRARSSMARVGWKSPSYSDFEEDRHRGRRRKKLLYYLPWNGTFYFSYNEHLFWFRSREKENDGYLQQVVTVSCFGSPTVLRQLFDDCRDGYLKLTNNKTAVFEYLRHGNWQRTSLKSIRPISTVVMDEEDKEGLLRDIESFLDPGALTWHANRGIPYRRGYLLYGPPGTGKSSLCLSLAGHFGLDMYILNLSGTHGVPLDQALIRAGRVDRKLELPNADEDAAFRLFCMVFKGAKGDIPDPKRKAEDDDDTVENYGRQFVRKIPDGEFSPAEIQSYLVEHRGSARMALGKVQEWMDRTRTERAKMARANAPTAASPSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H433</accession>
    <name>Q2H433_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cytochrome c oxidase polypeptide VIa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_06582</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome c oxidase subunit 6A family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222677.1">
        <property type="nucleotide sequence ID" value="XM_001222676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H433"/>
    <dbReference type="STRING" id="306901.Q2H433"/>
    <dbReference type="GeneID" id="4391088"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06582"/>
    <dbReference type="eggNOG" id="KOG3469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122515_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H433"/>
    <dbReference type="OMA" id="YINFRAR"/>
    <dbReference type="OrthoDB" id="5947505at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.95.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001349">
        <property type="entry name" value="Cyt_c_oxidase_su6a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018507">
        <property type="entry name" value="Cyt_c_oxidase_su6a_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036418">
        <property type="entry name" value="Cyt_c_oxidase_su6a_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02046">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81411">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01329">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="24"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ89963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="128" mass="14952" checksum="C1A81FC4C4E038D6" modified="2006-03-21" version="1">MFAQRQIARATQRLTAQARAQAQRRFASTETENSFVRERRHVKEHAGPTTANKGNPNSGIPPALILAGANAYMLWNEHWEHWSHMPPLEERVEYPYQNIRTKNYQWGDGDKTLFWNDSVNYHNKDKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4I6</accession>
    <name>Q2H4I6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial</fullName>
            <shortName evidence="7">Glu-AdT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_06429</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222524.1">
        <property type="nucleotide sequence ID" value="XM_001222523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4I6"/>
    <dbReference type="FunCoup" id="Q2H4I6">
        <property type="interactions" value="297"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H4I6"/>
    <dbReference type="GeneID" id="4391467"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06429"/>
    <dbReference type="eggNOG" id="KOG1211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_7_6_1"/>
    <dbReference type="InParanoid" id="Q2H4I6"/>
    <dbReference type="OMA" id="QPASYCG"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="9">
        <location>
            <begin position="58"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ89810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="524" mass="55830" checksum="6612657B0A6266E0" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H524</accession>
    <name>Q2H524_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_06241</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222336.1">
        <property type="nucleotide sequence ID" value="XM_001222335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H524"/>
    <dbReference type="FunCoup" id="Q2H524">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H524"/>
    <dbReference type="GeneID" id="4391155"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06241"/>
    <dbReference type="eggNOG" id="KOG1450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010730_3_0_1"/>
    <dbReference type="InParanoid" id="Q2H524"/>
    <dbReference type="OMA" id="ENTNEEW"/>
    <dbReference type="OrthoDB" id="437889at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF136">
        <property type="entry name" value="RHO GTPASE ACTIVATOR (RGD1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="421"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ89622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="578" mass="62455" checksum="FF71766E6D512892" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6G3</accession>
    <name>Q2H6G3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_05752</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">G proteins are composed of 3 units, alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G protein gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221847.1">
        <property type="nucleotide sequence ID" value="XM_001221846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6G3"/>
    <dbReference type="STRING" id="306901.Q2H6G3"/>
    <dbReference type="GeneID" id="4391314"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05752"/>
    <dbReference type="eggNOG" id="ENOG502S5Z5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163540_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H6G3"/>
    <dbReference type="OMA" id="CLTIINY"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000003">
        <property type="entry name" value="G-protein complex gamma subunit Ste18/GpgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041848">
        <property type="entry name" value="Ste18_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="12">
        <location>
            <begin position="23"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ89133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="93" mass="10445" checksum="4D3925BA91CD6816" modified="2006-03-21" version="1">MPQYTSRDGGDPSQIRKNKQSMADLKLRRLTELNSRLREDLDRERIPVSGASKSIIAYCNSTRDYMVPNVWGPVPKGEDPYAPQQSGGCCIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6I3</accession>
    <name>Q2H6I3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_05732</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221827.1">
        <property type="nucleotide sequence ID" value="XM_001221826.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2H6I3">
        <property type="interactions" value="641"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H6I3"/>
    <dbReference type="GeneID" id="4390103"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05732"/>
    <dbReference type="eggNOG" id="KOG0732">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000536_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H6I3"/>
    <dbReference type="OMA" id="VTPKDFM"/>
    <dbReference type="OrthoDB" id="5421at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05491">
        <property type="entry name" value="Bromo_TBP7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001218">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000061">
        <property type="entry name" value="ATPase family, AAA domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045199">
        <property type="entry name" value="ATAD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069:SF0">
        <property type="entry name" value="TAT-BINDING HOMOLOG 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="643"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1245"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1332"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1379"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1527"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="343"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1273"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1379"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1407"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1535"/>
            <end position="1546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ89113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1559" mass="171543" checksum="85F76E51BD13B91B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6M9</accession>
    <name>Q2H6M9_CHAGB</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221781.1">
        <property type="nucleotide sequence ID" value="XM_001221780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6M9"/>
    <dbReference type="GeneID" id="4390325"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05686"/>
    <dbReference type="HOGENOM" id="CLU_059597_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6M9"/>
    <dbReference type="OrthoDB" id="4590459at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="223" mass="25025" checksum="011B366BF1156630" modified="2006-03-21" version="1">MSESPFHYQVQAGLRDYLKASLGKLYTNTKDPTIRNLIRLVAEQGTAQIWVDGKLLKQADVSFGPVGSLPALACEHDLYYHDLDQQPGGQVDLYLSDFLGSAGLPPAYCRPSTAELAAGITRNPTITLTYERLRAIFRKARHLHNPTEFTIEVGDEEESPYEEAERRVAEARAESERRVAEARAESERRVAEARAESERQLAVLKRRVAELEQQMAEGRRGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7B8</accession>
    <name>Q2H7B8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_05447</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ88828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001221541.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="4391179"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05447"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_397391_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7B8"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="617"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="650"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ88828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="693" mass="74909" checksum="AECB8BE919B05FC2" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7G3</accession>
    <name>Q2H7G3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Indoleamine 2,3-dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_05402</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221497.1">
        <property type="nucleotide sequence ID" value="XM_001221496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7G3"/>
    <dbReference type="STRING" id="306901.Q2H7G3"/>
    <dbReference type="GeneID" id="4391212"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05402"/>
    <dbReference type="eggNOG" id="ENOG502QV6W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1796251_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7G3"/>
    <dbReference type="OMA" id="WRRAYCL"/>
    <dbReference type="OrthoDB" id="540174at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF10">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ88783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="15875" checksum="450AB301DC3A7D9A" modified="2006-03-21" version="1">MSPLETPGSLTKGVHTNTPPLSLQDYAVTSNGFLPEEPPLRRLPDPYYAPWESLVETLSISIAEQTLRQQIDRLPVLSTDRLTTEPEWRRACVVLAFLTHGYIWGGETASEGAEVEVWCQFTGGSNGQTLRRCSFLDVVLGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7K7</accession>
    <name>Q2H7K7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_05358</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221453.1">
        <property type="nucleotide sequence ID" value="XM_001221452.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4390392"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05358"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_37_4_1"/>
    <dbReference type="InParanoid" id="Q2H7K7"/>
    <dbReference type="OMA" id="GMMCDDW"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19532">
        <property type="entry name" value="C_PKS-NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="13">
        <location>
            <begin position="7"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="14">
        <location>
            <begin position="943"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="12">
        <location>
            <begin position="2343"/>
            <end position="2421"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="12">
        <location>
            <begin position="3526"/>
            <end position="3604"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="10">
        <location>
            <begin position="943"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="10">
        <location>
            <begin position="1095"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2431"/>
            <end position="2536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="3608"/>
            <end position="3645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="2469"/>
            <end position="2482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="2497"/>
            <end position="2508"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="10">
        <location>
            <position position="976"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="10">
        <location>
            <position position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ88739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3645" mass="392358" checksum="BD493C963849DFE5" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7P9</accession>
    <name>Q2H7P9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_05316</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221411.1">
        <property type="nucleotide sequence ID" value="XM_001221410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7P9"/>
    <dbReference type="STRING" id="306901.Q2H7P9"/>
    <dbReference type="GeneID" id="4391394"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05316"/>
    <dbReference type="eggNOG" id="KOG3077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047042_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H7P9"/>
    <dbReference type="OMA" id="LWCKFLQ"/>
    <dbReference type="OrthoDB" id="27198at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF31">
        <property type="entry name" value="DCN1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCUN1" evidence="3">
        <location>
            <begin position="76"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ88697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="327" mass="37401" checksum="3A134DC39A72B5C2" modified="2006-03-21" version="1">MPKATKEKKAAKSTKDKPYSKAARSDPTSRRLMSTLTKLFHRLAFSPGRKADDGVPYRYYNDNQNHGGSSNKSEAATRAQLNKFFDDLIPEEEKARSSEPISEIGAEQSMAYLERLEVNMANYELFVVLEIVKAESIGTITRSGFVDGWARVIAETSSHANSSMRVTPDWDGQQQYVRSRVAQALTDDDYFKTLYDFAFQVGREPPQKAVAMAVAVSFWEGLYEPHSNPWRSAHVNWLEQWTAYLREKYGVVKTNEDGEEEVEYKRTVSKDLWTQTRLFAIKTMKDETLGFWSEEQAWPGIIDDFVLWCREKGIVKETKPGDVMEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7R0</accession>
    <name>Q2H7R0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221400.1">
        <property type="nucleotide sequence ID" value="XM_001221399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7R0"/>
    <dbReference type="STRING" id="306901.Q2H7R0"/>
    <dbReference type="GeneID" id="4391489"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05305"/>
    <dbReference type="eggNOG" id="ENOG502SC5D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_279927_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7R0"/>
    <dbReference type="OMA" id="AKHHEIE"/>
    <dbReference type="OrthoDB" id="10255512at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.510">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="513"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="925"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="336"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="705"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="434"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="941"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="982" mass="107306" checksum="90B9C64FD54BC0E9" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H801</accession>
    <name>Q2H801_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynactin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_03653</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the dynactin subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230169.1">
        <property type="nucleotide sequence ID" value="XM_001230168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H801"/>
    <dbReference type="STRING" id="306901.Q2H801"/>
    <dbReference type="GeneID" id="4389049"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03653"/>
    <dbReference type="eggNOG" id="KOG3896">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034750_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H801"/>
    <dbReference type="OMA" id="CGYCMWT"/>
    <dbReference type="OrthoDB" id="283815at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008603">
        <property type="entry name" value="DCTN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034">
        <property type="entry name" value="DYNACTIN P62 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034:SF2">
        <property type="entry name" value="DYNACTIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05502">
        <property type="entry name" value="Dynactin_p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="503"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="511"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ91718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="630" mass="68503" checksum="9A3CE1D8833037D5" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H867</accession>
    <name>Q2H867_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230103.1">
        <property type="nucleotide sequence ID" value="XM_001230102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H867"/>
    <dbReference type="STRING" id="306901.Q2H867"/>
    <dbReference type="GeneID" id="4389727"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03587"/>
    <dbReference type="eggNOG" id="ENOG502SXHQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065008_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H867"/>
    <dbReference type="OMA" id="DATSWIW"/>
    <dbReference type="OrthoDB" id="5226655at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="322" mass="34558" checksum="42E82531CF18FC49" modified="2006-03-21" version="1">MGKPPFEMGGRPADENLPEAVQHPQPQPPMASATPLPEVVPDSSPEFAQPRHYMETDKYPVYYDAAPKFPHEPQTPGMQGMPSPGHQSHQPWTDAEHSVSMMSPNSSLPWQSFPPGDDQQTYVGSEPPAPEKRICGLRKRLFIIIAVIVALVVVGAAVGGGVGGSIAARQGSSDGAEPAETSSASSSSATGTSTDTGSTTTTPTASSTVSRGPDLPTPTISFLSNQTDRTYKGYALQVYEKNDFEGKASPIFWDEGFYDLGFDATSWIWVPNGLDACVTFCANKTTRTGFACTDRRKHATDDGISFKRVSVWRGAWQNGRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9L3</accession>
    <name>Q2H9L3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable vacuolar protein sorting-associated protein 16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_03091</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229607.1">
        <property type="nucleotide sequence ID" value="XM_001229606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9L3"/>
    <dbReference type="FunCoup" id="Q2H9L3">
        <property type="interactions" value="961"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H9L3"/>
    <dbReference type="GeneID" id="4389130"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03091"/>
    <dbReference type="eggNOG" id="KOG2280">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008909_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H9L3"/>
    <dbReference type="OMA" id="WCGDDCL"/>
    <dbReference type="OrthoDB" id="1792at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000635">
        <property type="entry name" value="Probable vacuolar protein sorting-associated protein 16 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007949">
        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="3">
        <location>
            <begin position="504"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR007949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ91156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="834" mass="93166" checksum="D73E76B92B945888" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAX8</accession>
    <name>Q2HAX8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_02626</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229142.1">
        <property type="nucleotide sequence ID" value="XM_001229141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAX8"/>
    <dbReference type="FunCoup" id="Q2HAX8">
        <property type="interactions" value="669"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HAX8"/>
    <dbReference type="GeneID" id="4389387"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02626"/>
    <dbReference type="eggNOG" id="KOG0991">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042324_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HAX8"/>
    <dbReference type="OMA" id="SCNYSSQ"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000007">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000107">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
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        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
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        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="64"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
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        <source>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ90691.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="356" mass="39488" checksum="09B78431CC56136D" modified="2006-03-21" version="1">MALAKGEEKGESSTAAYKAHAANPTGNPTYELPWVEKYRPVFLDDIVGNTETIERLKIIARDGNMPHLIISGMPGIGKTTSVLCLSRQLLGDSYKEAVLELNASDERGIEVVRQRIKGFAQKKVTLPQGRHKIVILDEADSMTSGAQQALRRTMEIYSNTTRFAFACNQSNKIIEPLQSRCAILRYAKLTDAQVVKRLLQIIEAEKVEYNDEGLAALVFSAEGDMRQAINNLQSTFAGFGFVSADNVFKVVDSPHPIKVQAMLKACYEGNIDSALDTLRELWDLGYSSHDIISTMFKVTKTIPTLSEHAKLEFIKEIGFTHMKILEGVQTLLQLSGCVARLCKLNMDPAKFELATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HB91</accession>
    <name>Q2HB91_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">beta-glucosidase</fullName>
            <ecNumber evidence="10">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_02513</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="10"/>
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        <property type="protein sequence ID" value="EAQ90578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001229028.1"/>
    </dbReference>
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    <dbReference type="STRING" id="306901.Q2HB91"/>
    <dbReference type="GeneID" id="4389702"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02513"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_2_1_1"/>
    <dbReference type="InParanoid" id="Q2HB91"/>
    <dbReference type="OMA" id="PAPYGGW"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF2">
        <property type="entry name" value="BETA-GLUCOSIDASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
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        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209024" description="beta-glucosidase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="13">
        <location>
            <begin position="618"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ90578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="718" mass="77944" checksum="710845539BA43BC2" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBB7</accession>
    <name>Q2HBB7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_02487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229003.1">
        <property type="nucleotide sequence ID" value="XM_001229002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBB7"/>
    <dbReference type="GeneID" id="4388863"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02487"/>
    <dbReference type="eggNOG" id="ENOG502QVK9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_281332_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HBB7"/>
    <dbReference type="OrthoDB" id="4760011at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="785"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="873"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="484"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="750"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="795"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ90552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1082" mass="113796" checksum="7473FE5A4A367A9F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBS2</accession>
    <name>Q2HBS2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CHGG_02332</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228848.1">
        <property type="nucleotide sequence ID" value="XM_001228847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBS2"/>
    <dbReference type="STRING" id="306901.Q2HBS2"/>
    <dbReference type="GeneID" id="4388425"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02332"/>
    <dbReference type="eggNOG" id="KOG0592">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_550932_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HBS2"/>
    <dbReference type="OrthoDB" id="5278984at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="209"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAQ90397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="495" mass="54192" checksum="4CA2BB45E709907D" modified="2006-03-21" version="1">MASQGPPPDPDVPAGTVFEAYPLAPVGTFLGIACITTGLRIYWRIKPTWRIGADDYTLVFALVLTIAWYGIDVAMYHYGRGIEGFVPDPWTMGPLIVADGVLWVWGLNVIRISAALLLLRLKDSLPWKLALGTVITIQACMLVVGTTMHLVMCQPISARWAPTPTAKCIPVPNFMIYGYVYSASDFTISILPITFIRNLRRPFYEKFLIGCLMTAGMGATGIAVARLFLIMGYLGKGTARINALQDFLWGMELTIGVLATSLPTLKAPVHGLLQSWGVLRSTSSSSDMSPDSFLDELTNGTHVENQMRQWNSLVHGITYGYLPHDLGAVKFGRYIRYAHQSSKFLDNGWNKQVAETIGLIHDAGIIHGDLTCANIFLDANLDARVADFAGSSIDGSPMLVVVTESHEFPGPLSSIRADLFALGCVLYEMITTGNPPYKELEDTEIRARYLKQHFPETTSLGAVGAVIEKYWRGSFPGAGSVFETLKSTPRSATKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCP9</accession>
    <name>Q2HCP9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_02005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221226.1">
        <property type="nucleotide sequence ID" value="XM_001221225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCP9"/>
    <dbReference type="GeneID" id="4387489"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02005"/>
    <dbReference type="eggNOG" id="ENOG502QRCI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008033_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HCP9"/>
    <dbReference type="OMA" id="PNAIAGY"/>
    <dbReference type="OrthoDB" id="5358475at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049046">
        <property type="entry name" value="Beta-AFase-like_GH127_middle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31151">
        <property type="entry name" value="PROLINE-TRNA LIGASE (DUF1680)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31151:SF0">
        <property type="entry name" value="PROLINE-TRNA LIGASE (DUF1680)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20736">
        <property type="entry name" value="Glyco_hydro127M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209131" description="Secreted protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 catalytic" evidence="3">
        <location>
            <begin position="38"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 middle" evidence="4">
        <location>
            <begin position="437"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="755"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ93770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="797" mass="87190" checksum="4FA73ECAB281327A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HD73</accession>
    <name>Q2HD73_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Molybdopterin synthase sulfur carrier subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Common component for nitrate reductase and xanthine dehydrogenase protein G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Molybdenum cofactor synthesis protein 2 small subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Molybdenum cofactor synthesis protein 2A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Sulfur carrier protein MOCS2A</fullName>
            <shortName evidence="5">MOCS2A</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cnxG</name>
        <name evidence="7" type="ORF">CHGG_01831</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by UBA4. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoaD family. MOCS2A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221052.1">
        <property type="nucleotide sequence ID" value="XM_001221051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HD73"/>
    <dbReference type="STRING" id="306901.Q2HD73"/>
    <dbReference type="GeneID" id="4386963"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01831"/>
    <dbReference type="eggNOG" id="KOG3958">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038287_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HD73"/>
    <dbReference type="OMA" id="SDMDIQP"/>
    <dbReference type="OrthoDB" id="4977at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990140">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030366">
        <property type="term" value="F:molybdopterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00754">
        <property type="entry name" value="Ubl_MoaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03051">
        <property type="entry name" value="MOCS2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028133">
        <property type="entry name" value="Dynamitin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028887">
        <property type="entry name" value="MOCS2A_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15346">
        <property type="entry name" value="DYNACTIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04912">
        <property type="entry name" value="Dynamitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="modified residue" description="1-thioglycine; alternate" evidence="5">
        <location>
            <position position="541"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycyl adenylate; alternate" evidence="5">
        <location>
            <position position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ93596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="541" mass="59573" checksum="A6C248FE0D9D96FF" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HD85</accession>
    <name>Q2HD85_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221040.1">
        <property type="nucleotide sequence ID" value="XM_001221039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HD85"/>
    <dbReference type="STRING" id="306901.Q2HD85"/>
    <dbReference type="GeneID" id="4387630"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01819"/>
    <dbReference type="eggNOG" id="ENOG502SHU8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071111_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HD85"/>
    <dbReference type="OMA" id="VAMVNHM"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF7">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="65"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="284" mass="31487" checksum="611B2BDDC0EF9CFF" modified="2006-03-21" version="1">MFSRRFEPSQTKSVSSKSGRSRRASSSFNKEAGISKRPVESGRRRAGTISNAGASESALGGSISAIVTLVVGQEQRIFAAHENILGASPFFQSVLKNQLMDSQTKKISLPDEEPEVFSSILEFLYKGDYYPRLVHNKKRNSWELEQAGEDGRSEATVYHHSVEGELLKDTAIYCAADKYGLEELKRISLRKQGLQSGIQASTILASARYAYANTPDTDSKLRAHYLALIIRSRSTFKRSGTMQLEMFNGNTQLFFDLFVALCNHVDDISSAASTPRTPRSGRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HD99</accession>
    <name>Q2HD99_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221026.1">
        <property type="nucleotide sequence ID" value="XM_001221025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HD99"/>
    <dbReference type="GeneID" id="4388300"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01805"/>
    <dbReference type="HOGENOM" id="CLU_756497_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HD99"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="366" mass="39102" checksum="8A997B00BC79DC29" modified="2006-03-21" version="1">MADPIRHHNPRSDIPDLQLSGPLPRRPVPHTQILDHGRIDFDGDPIRPATGIEEVARTQKIDKERCRLPTIITSTTRPHPLDSSSSSSSRRPLQPLLRKPHLLPDLPAVANAVVVLDPDRPAPARPVRHIVRPHRSVDAAPSDAYYSSSFCSFYSPFGGWGVAGQAEAADEDDAAAGLGEGGIWARSASLPRPVPSRLRERRMVSEGWASRKGVEGAEEGGEVFGAGEGDGEGGVDEAELGDWGFGGGAVAVAVAGGRGRGRGVDGAGDAHVEEAHAVVELVEDGHGLAAHRGQGDVTGGRVVRAGDGEGREGQRVVQRRHPGGEVGRAEERQVRVLRQVDGRELFGFFFFFLCVSGERFEDYAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDF5</accession>
    <name>Q2HDF5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="12">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_01749</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="12"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220970.1">
        <property type="nucleotide sequence ID" value="XM_001220969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDF5"/>
    <dbReference type="FunCoup" id="Q2HDF5">
        <property type="interactions" value="586"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HDF5"/>
    <dbReference type="GeneID" id="4386787"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01749"/>
    <dbReference type="eggNOG" id="KOG2623">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024003_4_0_1"/>
    <dbReference type="InParanoid" id="Q2HDF5"/>
    <dbReference type="OMA" id="TKIHYQL"/>
    <dbReference type="OrthoDB" id="337870at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000001">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000227">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032005">
        <property type="entry name" value="TyrRSs_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF0">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="TYROSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16714">
        <property type="entry name" value="TyrRSs_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tyrosyl-tRNA synthetase C-terminal" evidence="14">
        <location>
            <begin position="436"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="615"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ93514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="708" mass="80882" checksum="28B3634D3F4EF533" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDG9</accession>
    <name>Q2HDG9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Elongator complex protein 3</fullName>
            <ecNumber evidence="16">2.3.1.311</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">tRNA uridine(34) acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CHGG_01735</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ELP3 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.311" evidence="16"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220956.1">
        <property type="nucleotide sequence ID" value="XM_001220955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDG9"/>
    <dbReference type="STRING" id="306901.Q2HDG9"/>
    <dbReference type="GeneID" id="4386755"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01735"/>
    <dbReference type="eggNOG" id="KOG2535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025983_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HDG9"/>
    <dbReference type="OMA" id="CTEASFI"/>
    <dbReference type="OrthoDB" id="10265243at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000003">
        <property type="entry name" value="Elongator complex protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="18">
        <location>
            <begin position="111"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAQ93500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="271" mass="31279" checksum="244381364CFE6989" modified="2006-03-21" version="1">MPDLPNVGMERDLDQFKEYFESPAFRTDGLKIYPTLVIRGTGLYELWRTGRYQNYTPNGLIDLVARILALVPPWTRIYRVQRDIPMPLVSSGVENGNLRELALARMMDFGTTCRDVRTREVGVNEVKHKIRPNQIELVRRDYTANGGWETFLAYEDPKQDILVALLRLRKCSEKYTFREELVGQPTSLVRELHVYGMAVPVHARDPRKFQHQGFGTLLMEEAERIAREEHGSEKISVISGVGVRSYYAKLGYWLDGPYMSKWLNGRPGPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDK0</accession>
    <name>Q2HDK0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CHGG_01704</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220925.1">
        <property type="nucleotide sequence ID" value="XM_001220924.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2HDK0">
        <property type="interactions" value="977"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HDK0"/>
    <dbReference type="GeneID" id="4387514"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01704"/>
    <dbReference type="eggNOG" id="KOG0260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000487_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HDK0"/>
    <dbReference type="OMA" id="KPCMGIV"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140463">
        <property type="term" value="F:chromatin-protein adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180034">
        <property type="term" value="P:co-transcriptional lncRNA 3' end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02584">
        <property type="entry name" value="RNAP_II_Rpb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.140:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04990">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 15 19" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="18">
        <location>
            <begin position="242"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1586"/>
            <end position="1756"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="690"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1604"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1650"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1660"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1703"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1718"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1746"/>
            <end position="1756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAQ93469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1756" mass="194660" checksum="7B926D424592F284" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDV8</accession>
    <name>Q2HDV8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220817.1">
        <property type="nucleotide sequence ID" value="XM_001220816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDV8"/>
    <dbReference type="GeneID" id="4386344"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01596"/>
    <dbReference type="eggNOG" id="ENOG502RIYH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1137886_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HDV8"/>
    <dbReference type="OMA" id="WCYETTI"/>
    <dbReference type="OrthoDB" id="10368677at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="244" mass="25767" checksum="B7CE47BE7FBF6439" modified="2006-03-21" version="1">MLRLLPEEASAAGFLDNMNTPHTFPHSRASTPSEEWTFVDGSYTEARSPQLIHDNMPSGQVANASADGTPSFSLSEVAIADSNNNTTNNDSPGVAHRPPSNVSTETPGTNDTTRTVTDRPRTAPAPVAATRYTPGLAQQKLTHHNMAVYQRELEQSRTDNLADWAANAGMGSRRPVGRAPSSHPSSSVGYNSSVLAVGGHSMGSRGSSSIGGGVGDWAYVQSPMRGDEEVNAAGAWCYETTIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDY3</accession>
    <name>Q2HDY3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">14-3-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_01571</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220792.1">
        <property type="nucleotide sequence ID" value="XM_001220791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDY3"/>
    <dbReference type="STRING" id="306901.Q2HDY3"/>
    <dbReference type="GeneID" id="4387533"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01571"/>
    <dbReference type="eggNOG" id="KOG0841">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058290_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HDY3"/>
    <dbReference type="OMA" id="SKGTDKH"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000002">
        <property type="entry name" value="14-3-3 protein epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ93336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="266" mass="29753" checksum="C856EBBB293CE01D" modified="2006-03-21" version="1">MANETFLARLCEQAERYDEMVTYMKEVAKIGGELTVDERNLLSVAYKNVVGTRRASWRIISSIEQKEESKGSDKHVGTIRDYRQKIETELEKVCQDVLDVLDEALIPNAASGESKVFYHKMKGDYHRYLAEFASGEKRKVAATAAHEAYKSATDVAQTELTPTHPIRLGLALNFSVFYYEILNSPDRACHLAKQAFDDAIAELDSLSEESYRDSTLIMQLLRDNLTLWTSSDNGEPEGAAEAPKDKPADAPKEADGQAEEPAPEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEG7</accession>
    <name>Q2HEG7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_01387</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220608.1">
        <property type="nucleotide sequence ID" value="XM_001220607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEG7"/>
    <dbReference type="STRING" id="306901.Q2HEG7"/>
    <dbReference type="GeneID" id="4387700"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01387"/>
    <dbReference type="eggNOG" id="ENOG502QVF9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009617_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HEG7"/>
    <dbReference type="OMA" id="PSHFIGN"/>
    <dbReference type="OrthoDB" id="2283631at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF79">
        <property type="entry name" value="C6 FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="645"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="735"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="664"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="693"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="750"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ93152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="831" mass="92024" checksum="4A41F24D220C187B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEQ2</accession>
    <name>Q2HEQ2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_01302</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220523.1">
        <property type="nucleotide sequence ID" value="XM_001220522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEQ2"/>
    <dbReference type="SMR" id="Q2HEQ2"/>
    <dbReference type="STRING" id="306901.Q2HEQ2"/>
    <dbReference type="GeneID" id="4388328"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01302"/>
    <dbReference type="eggNOG" id="KOG0865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_39_2_1"/>
    <dbReference type="InParanoid" id="Q2HEQ2"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ93067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="86" mass="9277" checksum="C628B515A36B54FF" modified="2006-03-21" version="1">MAFPNGFGYKGSTFHRIIKNFMIQGGDFTRGNVSIPMMADDFGSGANLTQGTGGKSIYGEKFADENFQLRHNRPGLLSMANAGPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HER9</accession>
    <name>Q2HER9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Prolyl 4-hydroxylase alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_01285</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220506.1">
        <property type="nucleotide sequence ID" value="XM_001220505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HER9"/>
    <dbReference type="STRING" id="306901.Q2HER9"/>
    <dbReference type="GeneID" id="4388346"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01285"/>
    <dbReference type="eggNOG" id="KOG1591">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058132_0_2_1"/>
    <dbReference type="InParanoid" id="Q2HER9"/>
    <dbReference type="OMA" id="NIWPRRY"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF242">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="7">
        <location>
            <begin position="75"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ93050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="304" mass="33939" checksum="CCC560E91921F5F8" modified="2006-03-21" version="1">MTTTSIAKSAGFWAGGLLLGLSIPYLPNLSSPHLASFIGDFPIPDHPFPHHHPKPPPSSATPPTPTAPSSSPSTPLIIYIHNILTPSEITSLLATAEPKFAPSQVTKHGRKQQTNDRTSSSAGLPRDDPAVRCVLDRARTFLGTMLRDGWDEMGPPQLVRYSEGQRFNVHHDWYDVPQWAPDGTTRKWNRVASFFAILEDQCEGGETHFPFVEGIVRPSPYGEGMWKGGMRRKEGEREDEVKPLWREHEEGGLAFRPVAGNAVFWVNLHANDTGDMRTRHAGLPLESGRKTAMNIWPRRYYAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HET7</accession>
    <name>Q2HET7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lytic polysaccharide monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220488.1">
        <property type="nucleotide sequence ID" value="XM_001220487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HET7"/>
    <dbReference type="GeneID" id="4387379"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01267"/>
    <dbReference type="eggNOG" id="ENOG502S005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032571_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HET7"/>
    <dbReference type="OMA" id="AGTECKE"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF2">
        <property type="entry name" value="LYTIC POLYSACCHARIDE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209191" description="Lytic polysaccharide monooxygenase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="46599" checksum="2FDF41264C5BF08C" modified="2006-03-21" version="1">MMSPIVSAAGVAMLLLRGAHGHMVMNSPTPYNLDIQPLLQVDPISGGLYPYPCHNQYGFTHRTPVEAGGATLVNFTGGGQHGGGSCQFSITYDEPINGEDWNKSASFKTIYSIIGGCPAVFTDESHNLATVAVDENKRQDGKHCGNDSGVDCIRQFMIPIPKFLKNGPATFAWTWFNKLGNKEMYMNCAPIKITGGTGNETEIENLPNIFVANYPNDPEVTNCITGTRSDNVVVNFPEPGKYGRVLQDPVEPVNKPSGYCTQIPPARSLPTFEPGLTLAATPVGKAGPATTTPTPPVEDTTSPALGHSANDPITESAEVTTPVPTLTRSPPPIVIPANITTTIMKSSAIDLGVNPTPLTTPTPTPTPAAVGTGAIAKKPNSKAVACPSHGSIVCLDDGTFGLCDWGWVMPQRVAAGTECKEGKIVKRDEGNLVKRGGGEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFJ8</accession>
    <name>Q2HFJ8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_01006</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220227.1">
        <property type="nucleotide sequence ID" value="XM_001220226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFJ8"/>
    <dbReference type="GeneID" id="4387457"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01006"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_0_3_1"/>
    <dbReference type="InParanoid" id="Q2HFJ8"/>
    <dbReference type="OMA" id="SAYWSAV"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000026">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF2">
        <property type="entry name" value="ASPERGILLOPEPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013198122" description="Peptidase A1 domain-containing protein" evidence="6">
        <location>
            <begin position="16"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="126"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ92771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="439" mass="47230" checksum="D1D322A155687A6B" modified="2006-03-21" version="1">MKFAAFAFAASLVAAAPRVVQVHPSDIRPRRLGGSRFKLPQIHNDLFRQHGRGPRALAKAYEKYDIELPTDLIEVVQKILGELGIKPSPKKVTGFRPHGNGGAPYTNETDDQGEVSATPQLFDVEYLAPVEIGTPPQTLMLNFDTGSSDLWVFSSETPSNQQGGQKLYEIEKSSTATKLDNHTWSIHYGDGSRSSGNVYLDTVSVGGVNVFQQAVESATFVSSSFVSDAASSGLLGLAFDSINTVAPKKQKTYISNALESLEMGLFTANQKKAEAGRLQHRASSAGSEFIGPLSFIDAGNSSANNTAASMFVPISHTAYRRLRARPSSCSPRPSPRPTYFQVSGARTAAEVGGWVFPCDATLPDLTLHIGAYKAVIPGELMLFAPVDTDELETATVCYGGIQSASGMPFAIYGDVFFKAQFTVFDVEEGRLGFAPKPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFM3</accession>
    <name>Q2HFM3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytoskeleton-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220202.1">
        <property type="nucleotide sequence ID" value="XM_001220201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFM3"/>
    <dbReference type="STRING" id="306901.Q2HFM3"/>
    <dbReference type="GeneID" id="4386464"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00981"/>
    <dbReference type="eggNOG" id="ENOG502SE0J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051207_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HFM3"/>
    <dbReference type="OrthoDB" id="5385189at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ92746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="34524" checksum="D433A826041E308B" modified="2006-03-21" version="1">MAAKYFRAAGWLGRLIRDDRILFGYLAINALGWLFSVRVLLKKGRAELGTLDTLLGHYNQSIRETSAKIVCDRAINDRDTVDQLLWGITRKDYDERMKNVGALAIITDPQLSLDPEQEVLDDEDSDEYTLRDMTDKLCLMFISQLVSRFDAEKLVKAKFVEKWLAKQNWGATEEERQRNFAQYMRCRGNRINDIIASIRGSQAGREALERTGLLPPSSPTDSDPEDNVPLIERFSVLLPSNINISNLREDEQARLLIRSLQEAPTAEEQRVRHRHREAMVLNDGSRPVNSEDIIQRPESPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFR0</accession>
    <name>Q2HFR0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220165.1">
        <property type="nucleotide sequence ID" value="XM_001220164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFR0"/>
    <dbReference type="GeneID" id="4387145"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00944"/>
    <dbReference type="HOGENOM" id="CLU_683342_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HFR0"/>
    <dbReference type="OrthoDB" id="10349500at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="403" mass="43851" checksum="9C602B42F3D4A79F" modified="2006-03-21" version="1">MATRPDPSKQSIPLRSGPPQAQRPNPPTTNTQNVNQDKPVGATPAKPARKYEWPSDTPPDIRSATHGAIELAIRLLKTVPSRKHLVGLGLDIITSFSGQHLCPPDMDQRKMYSLVVFFLNSIDCEFPKLEYSRIQGAAALFQPTADWCVQRSGVPKGLRDWKPLASGGTLTLGDSVFGPLAASREERAKRPQPRPHQEGGVTSALRARHDEAYTRLQFAAGTCIAAHLVTCFVGLLTGANPRYVRESRPLGHSSWAFKWERAVLGGEVTTRMERRHPLGAGQGGTVWLVDERRWATRVDEECVRAVVGYDFVLPLVTTKEESHIEELPQTMEGVRAAHMAQLVHGAARVKRPEAKRVPSGNDPSSSGPNGPSSNGPSNSASSTTSSNPPPPRSRPTQTLQGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFR4</accession>
    <name>Q2HFR4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220161.1">
        <property type="nucleotide sequence ID" value="XM_001220160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFR4"/>
    <dbReference type="STRING" id="306901.Q2HFR4"/>
    <dbReference type="GeneID" id="4387826"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00940"/>
    <dbReference type="eggNOG" id="ENOG502S404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_930665_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HFR4"/>
    <dbReference type="OrthoDB" id="4150019at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="299" mass="32195" checksum="9E37EA7C3F3FA675" modified="2006-03-21" version="1">MAYQYPPPPPNGADMDMAPSGYLPSYSVAPHASSGMDPDSSIPRERSELRRSISTPVVGPPQGHPQQSPQQAGASGQDAAAERRRNKLGYHRTSVACVPRGGVRAANDPVASSTRAYEYGQHGMSSWMPADASPNSSKPNDMNATWRSYPGDSPVTPAFSPYTPHAPSSVAWSASVGSDSSSRDDITWSSYPAPPPRSMSFGAESMSGHTHYPSMSQPNHHSSRGLRTTIELLFVATVVLVLEARRRLWQRVSCVVESCCLQDASVVNGPAPPFTRLRTGGVTWSYNRSFDAVASMRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFV0</accession>
    <name>Q2HFV0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00904</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220125.1">
        <property type="nucleotide sequence ID" value="XM_001220124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFV0"/>
    <dbReference type="GeneID" id="4386356"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00904"/>
    <dbReference type="eggNOG" id="ENOG502SWNK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099493_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HFV0"/>
    <dbReference type="OMA" id="VPQNHFT"/>
    <dbReference type="OrthoDB" id="5400539at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020999">
        <property type="entry name" value="Chitin_synth_reg_RCR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12273">
        <property type="entry name" value="RCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ92669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="195" mass="21644" checksum="8BACC8A2EFB2AB8F" modified="2006-03-21" version="1">MAPTVIHLLARQFENCTFTEDGYLDEDSCYVPFWSTRTGTIVKWSLFLGIIVMTGLYLLVGYVHAQKRIKKGLPPLGYHRFLVSRATLARVDPRYRPAQPGAVYIPTTAERNYYDMHAMPPPVYDPNAPRPPMYEPPAGSAKIEPNQQQHGSQPSQSPSEERFEYGPPPGSPPVPGPSQETYAPPPGPPPSTARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG73</accession>
    <name>Q2HG73_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220002.1">
        <property type="nucleotide sequence ID" value="XM_001220001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG73"/>
    <dbReference type="GeneID" id="4386880"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00781"/>
    <dbReference type="eggNOG" id="ENOG502S7T4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015973_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HG73"/>
    <dbReference type="OMA" id="EQDMAFT"/>
    <dbReference type="OrthoDB" id="5344169at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11392">
        <property type="entry name" value="bHLH_ScPHO4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="461"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ92546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="560" mass="59867" checksum="4BABEAFB0A2864C3" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGC7</accession>
    <name>Q2HGC7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_00727</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219948.1">
        <property type="nucleotide sequence ID" value="XM_001219947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGC7"/>
    <dbReference type="FunCoup" id="Q2HGC7">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HGC7"/>
    <dbReference type="GeneID" id="4386805"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00727"/>
    <dbReference type="eggNOG" id="KOG2258">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030006_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HGC7"/>
    <dbReference type="OMA" id="RALPECW"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08570">
        <property type="entry name" value="GDPD_YPL206cp_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43805">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43805:SF1">
        <property type="entry name" value="GP-PDE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="3">
        <location>
            <begin position="37"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ92492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="347" mass="37722" checksum="BFB6A081D6188452" modified="2006-03-21" version="1">MSPEEMPLLQDGALQAGASGTIGAAESGPGSGKPRLPQNIGHRGYKAAFPENSMAAFHGAVVAGAHALETDLHLSRDGVVVLSHDATLKRCFGIDTKIADCDWSYLRTLQTLQEPRQGMPRLSDLLEWLARPELASVWLLLDIKTDDDPEVLLPAIARTVASVPPWEGGKGWKEKIVVGAWNENYIHHARLHLPGHALAYIGFSLLYARRFLSDQHPDVHFNLFQPSLVGPLGAAFRRAARERGRKLFVWTVNEEEWMEWAVRKGVDGVITDEVGRLSGVLDRLGAGAGVGGVVVVPGAKWPHALGLYARAVVMQAAALVFSLLLWRRLSTMGSRRKPGSVTVPGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGE2</accession>
    <name>Q2HGE2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_00712</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219933.1">
        <property type="nucleotide sequence ID" value="XM_001219932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGE2"/>
    <dbReference type="STRING" id="306901.Q2HGE2"/>
    <dbReference type="GeneID" id="4386733"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00712"/>
    <dbReference type="eggNOG" id="KOG0712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043818_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGE2"/>
    <dbReference type="OMA" id="GPTHEDI"/>
    <dbReference type="OrthoDB" id="436519at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051948">
        <property type="entry name" value="Hsp70_co-chaperone_J-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209453" description="J domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="76"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ92477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="322" mass="35811" checksum="6BA525788083036B" modified="2006-03-21" version="1">MSALLSLLGWSFLPNLVTGWTQSLYYSITIRAGDPKPQPGTPRWAEHRLRIHIAVVALYLLYTIYEADYDLQRAGTYYTDLGVPLDATEREIKSRFRRLAALHHPDKVSSSTVGGSGPTHEDINAYFVHLKMAADALADPARRFTYERFGPDVVGWMRCMTAHSVTRPGMPRVLERVVNPLLGRLAGRPPYLPFQAIALARKLSVTVYIAFSQIGPLLAADTRSGQLVVSATKGGDDEKALREGLERLEAAVKRLDVDTTRLLETEMAPFAGTEDTRSTMWAKVKEWLVQNTIRSDPMVRDALGKSFAKRRMEAPAGARGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGJ3</accession>
    <name>Q2HGJ3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">R3H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219882.1">
        <property type="nucleotide sequence ID" value="XM_001219881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGJ3"/>
    <dbReference type="STRING" id="306901.Q2HGJ3"/>
    <dbReference type="GeneID" id="4386692"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00661"/>
    <dbReference type="eggNOG" id="KOG2953">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017788_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGJ3"/>
    <dbReference type="OMA" id="PFCRVPP"/>
    <dbReference type="OrthoDB" id="278430at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02637">
        <property type="entry name" value="R3H_PARN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034042">
        <property type="entry name" value="PARN_R3H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="712" mass="75432" checksum="AB082BB1B3A80413" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGK2</accession>
    <name>Q2HGK2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_00652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219873.1">
        <property type="nucleotide sequence ID" value="XM_001219872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGK2"/>
    <dbReference type="GeneID" id="4386702"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00652"/>
    <dbReference type="eggNOG" id="ENOG502R9Z7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182433_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HGK2"/>
    <dbReference type="OMA" id="CHYARND"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ92417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="105" mass="11993" checksum="9F595F6A9DD2B8FB" modified="2006-03-21" version="1">MCAYEEYIFTCGHARYGLVCYCHRARNHPTRRCDFVKTLDKIWHQGRLCDPCQAAWAACHQSQGQGQGEGQRQGQGQARYRSTTICWEGGGFIPLADVSIRHHCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGM1</accession>
    <name>Q2HGM1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219854.1">
        <property type="nucleotide sequence ID" value="XM_001219853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGM1"/>
    <dbReference type="GeneID" id="4387134"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00633"/>
    <dbReference type="HOGENOM" id="CLU_1731248_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGM1"/>
    <dbReference type="OrthoDB" id="10627921at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="151" mass="16551" checksum="179CA5138625E3F8" modified="2006-03-21" version="1">MFPITSSLLLQEGQQLQRSGLRAGCNGDHKNFSIAGTGAVCCFFPSLRLSDHSVTPREAGERVWQSESVASKDNGSGEQTGLTRGGLPDCTVSDAILPPHRLAGWQEQRGRRGLRALIRSPKSIRHRCPTPLTVFFLFTSLRFGASIFPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGN0</accession>
    <name>Q2HGN0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219845.1">
        <property type="nucleotide sequence ID" value="XM_001219844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGN0"/>
    <dbReference type="GeneID" id="4387228"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00624"/>
    <dbReference type="HOGENOM" id="CLU_1731247_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGN0"/>
    <dbReference type="OrthoDB" id="10340987at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="151" mass="16146" checksum="9D60D12B4250B9E4" modified="2006-03-21" version="1">MSMKDPIHSLQGSVVALGAAGLDGLMAKTPQRCARTPRKREDERGITERHSRLRSIKERHLVIRQAPYALLATSLSDWGRVIRRSSSCMAVLVFEAPLQLASTMATLLPGGSPPGSSIRAKIAAVIPTTRVYSAGKDGRTNTAAVGGYLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHC8</accession>
    <name>Q2HHC8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CSN8/PSMD8/EIF3K domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_00376</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219597.1">
        <property type="nucleotide sequence ID" value="XM_001219596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHC8"/>
    <dbReference type="FunCoup" id="Q2HHC8">
        <property type="interactions" value="1113"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HHC8"/>
    <dbReference type="GeneID" id="4387864"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00376"/>
    <dbReference type="eggNOG" id="KOG3151">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046003_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HHC8"/>
    <dbReference type="OMA" id="HIMDGYF"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006746">
        <property type="entry name" value="26S_Psome_Rpn12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSN8/PSMD8/EIF3K" evidence="3">
        <location>
            <begin position="107"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ92141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="283" mass="30634" checksum="F5DAA163D2D2EE7F" modified="2006-03-21" version="1">MADRELSQLLARLKAAPPSAPYAETAALLSRAKLLLLQLGALTPTATAATSSPALLALARDTYEQGALASIRAKDPDAFTRYVAQLRPFYELLPVGGGGGEEGERNKVTGLYLLLLLTQGLYGEFHSELEALSAGGGGVDVEGDRYLGYPVRLERWLMEGSYDRVWKAMKKGEVPCEEFGVFSELQILTSQIRSEIASSSERAYPSLPLSSTKSLLFLQSEGAVVEMRRSRGWIVKDGQIFCPLGPRDGRGGAGEGDEPDGDREYLGLCPPARDDRLVGSIMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHM6</accession>
    <name>Q2HHM6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219499.1">
        <property type="nucleotide sequence ID" value="XM_001219498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHM6"/>
    <dbReference type="GeneID" id="4387336"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00278"/>
    <dbReference type="HOGENOM" id="CLU_1133463_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHM6"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="245" mass="26161" checksum="E97F082D159B39C9" modified="2006-03-21" version="1">MVRRMPRQMHHPPPQPPHPKHRIILPQQIKHPFILGPLHAIPLPKQTLHLPNPPPNTHRRRRHHTIIVPTLRRRQPPLQVEGRREVVGVSVGFEDVGDGVAAGVDEGEEGVGGGGGHGAGGGVVVQYRVDDGCCVGRWVGDEVLPGAGLRVEEAVDGGLWGFGGWGGGGGGGGGEDSHLESRLESQEDINGDKPDTTGSPDVKVDSAYRGSTYKSPSRGPDRSQGLVPAPADSRESRLRSSKRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GLY0</accession>
    <name>Q2GLY0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_11076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408038">
        <property type="protein sequence ID" value="EAQ82900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230252.1">
        <property type="nucleotide sequence ID" value="XM_001230251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GLY0"/>
    <dbReference type="GeneID" id="4397377"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_11076"/>
    <dbReference type="eggNOG" id="ENOG502S130">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_25_0_1"/>
    <dbReference type="InParanoid" id="Q2GLY0"/>
    <dbReference type="OrthoDB" id="5082906at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ82900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="28936" checksum="4CEC7767162CB122" modified="2006-03-21" version="1">MSPHTRHIQLARTQKKQAGPNFENRLQRPDLDDGRGGKKTAASVVLTACRKIQQRLSSRRGNRGRPRTLGPQGPTAVERAAGTVMRWTGGTVDTNRVVEEAWKARWLKERDGRAITRPADDFDHQQETLFRNETLRRHDGLSKAKSSLLIQIRTGAIGLRDFLFTRGVPEVLTPACECGEGRETAEHLVVWCLAPPLTRRWERTGIWTRRDFYSVLHGTNPTTARLARRVLDWLMDSGKLPMYNLARRLELEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMU1</accession>
    <name>Q2GMU1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Leptomycin B resistance protein pmd1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_10713</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228640.1">
        <property type="nucleotide sequence ID" value="XM_001228639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMU1"/>
    <dbReference type="FunCoup" id="Q2GMU1">
        <property type="interactions" value="668"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GMU1"/>
    <dbReference type="GeneID" id="4396698"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10713"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_17_8_1"/>
    <dbReference type="InParanoid" id="Q2GMU1"/>
    <dbReference type="OMA" id="IEFHNTV"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="689"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="721"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="6"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="319"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="641"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="789"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="546"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ84309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1037" mass="111969" checksum="674D6CF7BED14E08" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMV7</accession>
    <name>Q2GMV7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_10697</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228624.1">
        <property type="nucleotide sequence ID" value="XM_001228623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMV7"/>
    <dbReference type="STRING" id="306901.Q2GMV7"/>
    <dbReference type="GeneID" id="4396965"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10697"/>
    <dbReference type="eggNOG" id="ENOG502QTQH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_285126_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GMV7"/>
    <dbReference type="OMA" id="TAVFEFQ"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208812" description="FAD-binding PCMH-type domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="653"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="739"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="767"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="805"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="839"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="902"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="939"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="10">
        <location>
            <begin position="151"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="972"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="996"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="972"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1003"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ84293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1114" mass="121275" checksum="B7BEE65C41D12C96" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMY2</accession>
    <name>Q2GMY2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Erythromycin biosynthesis protein CIII-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228599.1">
        <property type="nucleotide sequence ID" value="XM_001228598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMY2"/>
    <dbReference type="GeneID" id="4396743"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10672"/>
    <dbReference type="eggNOG" id="KOG1192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000537_4_1_1"/>
    <dbReference type="InParanoid" id="Q2GMY2"/>
    <dbReference type="OMA" id="PGNAQMA"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21015:SF22">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21015">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--N-ACETYLMURAMYL-(PENTAPEPTIDE) PYROPHOSPHORYL-UNDECAPRENOL N-ACETYLGLUCOSAMINE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="2">
        <location>
            <begin position="296"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="421" mass="45620" checksum="E09D53F7147DC86E" modified="2006-03-21" version="1">MTVLKEKPIIVAAAFPASGHTAGLMRISEYLIEKGHELYFITRADFKAATDKIGAHFVENPWSWEEVFASRPPDSDEMWNFKNIFANSTPLAHRALKDTLEQVRRNHPERDVVILHESFSGGLGPFLHGAPLPEGYTVLPKIINFHTSVYLPGDASFPPFGPGLPYDPTPENLALWQSISDAMKPAMGELTEHYNTLYKSLGATQAMTTPILSRAMGFGDVTLLATTASLEWPTVTANAALPADSPDKKKVVFVSQGTVHRKPTELILPALAGLAERKDLLVIATLGDRGAELEGAARAALPGNAFVVDYLEYEAVLPHTDVFVSNAGYGGFMQGVMNGVPMVLAGTMADKAEVSARAEWAGVAVNLRAQEPGPDAIRAAVDKVLADGRFKETVVRLQKENQDLDAFGKIDEILEELTGDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN01</accession>
    <name>Q2GN01_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_10653</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228580.1">
        <property type="nucleotide sequence ID" value="XM_001228579.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GN01"/>
    <dbReference type="GeneID" id="4396309"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10653"/>
    <dbReference type="eggNOG" id="KOG0730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1807">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001133_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GN01"/>
    <dbReference type="OMA" id="GNMETFM"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17936">
        <property type="entry name" value="EEXXEc_NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001660">
        <property type="entry name" value="NF-X1 finger and helicase protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000216">
        <property type="entry name" value="Type VII secretion ATPase EccA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000160">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050773">
        <property type="entry name" value="CbxX/CfxQ_RuBisCO_ESX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN / ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392:SF2">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN _ ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="492"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="1599"/>
            <end position="1960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1245"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2050"/>
            <end position="2082"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="2100"/>
            <end position="2149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1251"/>
            <end position="1265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ84249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="2183" mass="243630" checksum="DEDF2FF54CC5889A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN12</accession>
    <name>Q2GN12_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_10642</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228569.1">
        <property type="nucleotide sequence ID" value="XM_001228568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN12"/>
    <dbReference type="GeneID" id="4396027"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10642"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_23_6_1"/>
    <dbReference type="InParanoid" id="Q2GN12"/>
    <dbReference type="OrthoDB" id="4842715at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="4">
        <location>
            <begin position="492"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="311"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="865"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="336"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="896"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ84238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="928" mass="103955" checksum="390F0EF7B4D613F2" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN93</accession>
    <name>Q2GN93_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_10561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228488.1">
        <property type="nucleotide sequence ID" value="XM_001228487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN93"/>
    <dbReference type="GeneID" id="4395940"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10561"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001248_0_2_1"/>
    <dbReference type="InParanoid" id="Q2GN93"/>
    <dbReference type="OrthoDB" id="5095382at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="397"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="863"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ84157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="896" mass="98106" checksum="EB7405B8E2707603" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNB4</accession>
    <name>Q2GNB4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Potassium channel tetramerisation-type BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228467.1">
        <property type="nucleotide sequence ID" value="XM_001228466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNB4"/>
    <dbReference type="FunCoup" id="Q2GNB4">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GNB4"/>
    <dbReference type="GeneID" id="4396000"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10540"/>
    <dbReference type="eggNOG" id="ENOG502QRM9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017395_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GNB4"/>
    <dbReference type="OMA" id="PHEKVFP"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31758">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN YLR108C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31758:SF2">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN YLR108C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="53414" checksum="F01735C7823EB3A2" modified="2006-03-21" version="1">MPSSTVGAEELFLESGVSTHHIPNILPHERVFPVQLGSELFKLSGASISSDAPSYFSQYFRCQVKRAEEAGQDIGSAIRTLYIDRDPITFRDISLHLQGYHVQPRDATHFVRLFADAQFYHLPKLVSQLYEEPIFTTIGGVQFRIPRDLFSAPGNSPNFFTLGFAAFFSAPGGDLFPGLDREGLLRPPSIIPPSVEGRSPETFAELLHLLRGYPVAIRGEQHRAELLRDCRYFNFKGLEQRLIPSAVSFNLARGRDEIVLRLRDILKSGIAVAAEPTATDPRAGWVNYGRPFVDERALELVLEIGDESTRLRIVPGQGAGEGAVEARAEFFGEMRARVTKLLEVVATKLGLPPTAQLGGLLMGKGTGGSAPPSPGNTPLSEDLVKVLLDSESSVMLDGKPWTPVPEEEQLAWTTGSIDAALMPRKRKRVDEQGDAEEWIVKTGQWRLRLQGARNGKAAVECCLVAVKLDAYSSERARNGQRPFLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNF0</accession>
    <name>Q2GNF0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228431.1">
        <property type="nucleotide sequence ID" value="XM_001228430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNF0"/>
    <dbReference type="GeneID" id="4396203"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10504"/>
    <dbReference type="eggNOG" id="ENOG502SZB5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1120055_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNF0"/>
    <dbReference type="OrthoDB" id="5059038at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="248" mass="27443" checksum="854DF9A02B571512" modified="2006-03-21" version="1">MALEKLPASICHRHITVITRNQSALAAVGQPRQQSGQSIIRQIYDLARLHRQRGNSVNFLWIPAEIDFALGSDAKAAAQRASKQGRTPDSQIPQAKSTAMRLAMERQRATRVLFVSVGKFSKAMDAALPDKHTRHLYDKLKRKGGLRIGAAPNRNGETKRFFEQDWGGRVRPLCLWTSEGISGTLSFPMREMDSSEGRHAAMHSGKTRKPLVLSGRESAIGYKALVTRYEGSPGDDQIRNGNRKAGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNH7</accession>
    <name>Q2GNH7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SsuA/THI5-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228404.1">
        <property type="nucleotide sequence ID" value="XM_001228403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNH7"/>
    <dbReference type="STRING" id="306901.Q2GNH7"/>
    <dbReference type="GeneID" id="4396058"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10477"/>
    <dbReference type="eggNOG" id="ENOG502T6ZQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028871_9_2_1"/>
    <dbReference type="InParanoid" id="Q2GNH7"/>
    <dbReference type="OMA" id="WIEHTPQ"/>
    <dbReference type="OrthoDB" id="5194099at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024">
        <property type="entry name" value="ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024:SF42">
        <property type="entry name" value="ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208422" description="SsuA/THI5-like domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="SsuA/THI5-like" evidence="2">
        <location>
            <begin position="44"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="327" mass="35869" checksum="B927AE519ABB38C3" modified="2006-03-21" version="1">MHLLDPLTLLLTLPPPTHALKIACVQQWIEHTPLPHAASTFYTPQNPSDPPITIVTGGVANLATDRSIDLAANAETQGLKNYNQHRNHRLIGILVEVTYRLVARRASGITTLTDLRGKRIGTIPGTSAEVFVRQLMGSAGLQAGRDYTTVAGGLSTCMRAPCGRGSFPAELVAGRIDAFGVWETAVELGVQALMHEEGGQGAVTFKNASVYREVYSLYSTEEKLRNPVVRGRIVRFVRALNQSFGVFREGGQEVVDYVGKKVGVDEPVLRNVWEDHVWGPGNLGTGLLDYLEQEDQYLAKVDNRKALTRAELEKFVDTSVYEEAMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNU7</accession>
    <name>Q2GNU7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_10357</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TBCB family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228284.1">
        <property type="nucleotide sequence ID" value="XM_001228283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNU7"/>
    <dbReference type="FunCoup" id="Q2GNU7">
        <property type="interactions" value="627"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GNU7"/>
    <dbReference type="GeneID" id="4396944"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10357"/>
    <dbReference type="eggNOG" id="KOG3206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067577_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GNU7"/>
    <dbReference type="OMA" id="DQYEQRT"/>
    <dbReference type="OrthoDB" id="5295208at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01789">
        <property type="entry name" value="Ubl_TBCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045172">
        <property type="entry name" value="TBCB_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="5">
        <location>
            <begin position="181"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ83953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="240" mass="26399" checksum="9A4891A75CC5CDD4" modified="2006-03-21" version="1">MADVPLYVVSDYTSSERRITPAWSISQLKTKLETITGIPPSCQQISLKTSSGEKIAVEAPDEESVYLQQFPLAPYAELLVGDTRPASARPNFSSTAGVEKYVLPEEEYEKKTDSVLAWKKTEKLGRFDPNAASHEQAKISAIAQEIEVRGIAVGKRCQIGDDDSRRGEIKYVGDVKEIPGPGAWVGIQLDEPVGKNDGSIGGSRYWGEESQLKHGVFVRPDRVEVGDFPALDDLEDMEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNV3</accession>
    <name>Q2GNV3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7598 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_10351</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228278.1">
        <property type="nucleotide sequence ID" value="XM_001228277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNV3"/>
    <dbReference type="STRING" id="306901.Q2GNV3"/>
    <dbReference type="GeneID" id="4397048"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10351"/>
    <dbReference type="eggNOG" id="ENOG502SAQI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066685_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GNV3"/>
    <dbReference type="OMA" id="FWRIVIS"/>
    <dbReference type="OrthoDB" id="5327148at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056019">
        <property type="entry name" value="DUF7598"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24535">
        <property type="entry name" value="DUF7598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7598" evidence="3">
        <location>
            <begin position="14"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ83947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="317" mass="35693" checksum="54E6F9DED0D2AA6E" modified="2006-03-21" version="1">MFRLGQDSKLLGAGHVVLNVLRAFNMIGLAAAMVASMVMPVLSGINGHFYFFDMITHVFVFFFATFLFVSELPVPWRKLKGYYERNWPVLGPDHSLAWLGWGMVFIGFQILGDAWKPAYTVETIGLDWWRAILAAAILSVTFGFFNICASIIFRTSIDGLRGEVVKVTSRQIRTHGNLSLQNAANKNDDIEHSFSSHYSSPHRDNWSAQSWSKEEEAVGPSSAVKRLTRAFNPRNFNFRKSRIQISKPIPQNTADDVERGHSSHSRGDSFDDNLNGHGEDRGSPIMPGLQRPPTELHPAYMPKSRTSLYSAAHMDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GP27</accession>
    <name>Q2GP27_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_10277</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228204.1">
        <property type="nucleotide sequence ID" value="XM_001228203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GP27"/>
    <dbReference type="STRING" id="306901.Q2GP27"/>
    <dbReference type="GeneID" id="4396164"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10277"/>
    <dbReference type="eggNOG" id="ENOG502SM2K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023111_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GP27"/>
    <dbReference type="OMA" id="CHACEST"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208306" evidence="3">
        <location>
            <begin position="18"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ83873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="479" mass="52538" checksum="77039417801B4DF9" modified="2006-03-21" version="1">MAALSTVLALLASTALAGPSNEHVHVESSTDRHSSASAIAFVQGLYPPFPHVSCDSDVPGHNWMSDGSVLNYPLGGYQYPNIRTIAPDRDPDSIWAHGHGLCRKHEQSMLAFSNNSMANSLHQDSRLFYSNLWDKLFCEAFPRSEASFYNAHELYEYAAYRWTHENSSRSAITLDDLETLRHLAWQQQSLKHGYSENAQDGSTSTIAGRTLASRVAALFTENIETRGERNKLNLAFTSHEPFLSFFALADLNAGPSSDLFSQLPEPGATLTFELFSVDESVDSYEAESLTGSDAYGSDPSDNNDDAYSQTDSYGNTPGPYGAKTRRSLYSDHEATYDQKSIGAYSMQSPPHQEPLCAPSPTHNSNDNPPYPSADKLYVRFLYQNHHNGSAADKYTPCPLFGNTQTSIPFKQFHEIISTIGIANATTWCHACESTNSIFFCEGAVIAHDEHHHHLLAVLLGSASTLLAVAVVLALIGLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GP48</accession>
    <name>Q2GP48_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-amylase/branching enzyme C-terminal all beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228183.1">
        <property type="nucleotide sequence ID" value="XM_001228182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GP48"/>
    <dbReference type="SMR" id="Q2GP48"/>
    <dbReference type="STRING" id="306901.Q2GP48"/>
    <dbReference type="GeneID" id="4396086"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10256"/>
    <dbReference type="eggNOG" id="KOG0470">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011131_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GP48"/>
    <dbReference type="OMA" id="FSWEVLR"/>
    <dbReference type="OrthoDB" id="196493at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000338">
        <property type="entry name" value="1,4-alpha-glucan branching enzyme, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000003">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-amylase/branching enzyme C-terminal all beta" evidence="2">
        <location>
            <begin position="242"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="348" mass="39844" checksum="69FEDF4668080D99" modified="2006-03-21" version="1">MLYTHHGIGTGFSGGYHEYFGAAVDEEAVVYLMIANEMLHELYPNAITVAEDVSGMPALCLPLSLGGVGFDYRLAMAIPDMWIKILKEKKDEDWDIGNICFTLTNRRHGEKTIAYAESHDQALVGDKSLMMHLCDAELYTNMSTLAPLTPVIDRGMALHKMIRLLTHGLGGEGWLNFEGNEFGHPEWLDFPREGNQNSFWYARRQLNLTEDHLLRYQFLNNFDRSMNVCEGKYGWLHAPQAYISLKHEGDKVIVFERAGLVFVFNFHPTQSFTDYRIGIEDAGTYRIVLDSDTKDNGGFCRLDEGTRFFTQPLEWNGRKNCMHVYIPCRTAFVSRRGHREILLYPSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPI1</accession>
    <name>Q2GPI1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228050.1">
        <property type="nucleotide sequence ID" value="XM_001228049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPI1"/>
    <dbReference type="GeneID" id="4396849"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10123"/>
    <dbReference type="HOGENOM" id="CLU_1981407_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPI1"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ83719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="126" mass="14250" checksum="3539FC0107D602F5" modified="2006-03-21" version="1">MSRLVDPRTYELLLERNKPRSLDVPDFLRVLENRPRIVFFCLAAKECKRDAKGGPSRINADHIEKRHAVLVRLVRAVKEEEVGVRSKIAIKRVGMREEDGCNPAMRGPCLRGDRDTIAALNLSTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQ11</accession>
    <name>Q2GQ11_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar import and degradation protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_09943</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227870.1">
        <property type="nucleotide sequence ID" value="XM_001227869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQ11"/>
    <dbReference type="FunCoup" id="Q2GQ11">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="GeneID" id="4396676"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09943"/>
    <dbReference type="eggNOG" id="KOG2395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007002_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQ11"/>
    <dbReference type="OMA" id="RLNETKW"/>
    <dbReference type="OrthoDB" id="10251113at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040458">
        <property type="entry name" value="Vid27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013863">
        <property type="entry name" value="VID27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040979">
        <property type="entry name" value="Vid27_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040768">
        <property type="entry name" value="Vid27_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913:SF0">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08553">
        <property type="entry name" value="VID27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17748">
        <property type="entry name" value="VID27_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17747">
        <property type="entry name" value="VID27_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vid27 N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Vid27 PH-like" evidence="3">
        <location>
            <begin position="250"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar import/degradation Vid27 C-terminal" evidence="2">
        <location>
            <begin position="431"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ83539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="814" mass="91826" checksum="57DD0A653A187D25" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQ47</accession>
    <name>Q2GQ47_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227834.1">
        <property type="nucleotide sequence ID" value="XM_001227833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQ47"/>
    <dbReference type="GeneID" id="4396080"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09907"/>
    <dbReference type="HOGENOM" id="CLU_1970282_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQ47"/>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="127" mass="12902" checksum="D09A4EC515975CDA" modified="2006-03-21" version="1">MAEVAAAAIAAEQVVATGVEAAAAVAIAAPTLPLKIALTHLPNPAPEGSPHPALCRSHHTLTVLRNKAYIFGGLDPSGTLCPPGIHTITLPSSPTATDPASVAAPPTNNDNEQYNNNNDDNNLDADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQN4</accession>
    <name>Q2GQN4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LCCL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_09720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227647.1">
        <property type="nucleotide sequence ID" value="XM_001227646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQN4"/>
    <dbReference type="GeneID" id="4396966"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09720"/>
    <dbReference type="eggNOG" id="ENOG502QUEX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_613938_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQN4"/>
    <dbReference type="OMA" id="KRNNECG"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF8">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G02970)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00603">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50820">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="3">
        <location>
            <begin position="192"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ83316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="446" mass="49543" checksum="1B7C5D658461DE4E" modified="2006-03-21" version="1">MQVSEVTDEEVQLLHDEDYERFELDDASQPRRQLQDQSGSRGFWSRNRAPKWLAFLYGPDPPKIHTINPIFPSVQQLPRKWLEKALPGRWQRIGLLILFLLAWATSLAIPLILSKGTATDASGAAIRHIDCVDTLWKRNNECGLDGINCRPFSNTSFAFRCPADCASVRVLNPHHVGNQDVNFRPLVVGGGGNGPYRGDSFLCGAAIHAGVIRDTTGGCGVATLVGEYYQYFSSSQHNIESIPFDSYFPLSFTITADPTLKCTAPDPRWTVSLPLSILFTVLLTIFTTSPALYFFTTFLGIFTHVALVSDPPNLSTPSTTYLLPSLISHYAGRLLPAIFTAAIIYLTSVRHTLSPPPPPDSPHPPHPKNHPLETTLLHPPSSSRYRGWFAEQPLEEQVFKWTREAGRVVDEYFGFGFVTEGGRALDYTEAGTWFANGSWSQGAGYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQS3</accession>
    <name>Q2GQS3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mRNA 3'-end-processing protein RNA14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_09681</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Nucleus and/or cytoplasm.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227608.1">
        <property type="nucleotide sequence ID" value="XM_001227607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQS3"/>
    <dbReference type="FunCoup" id="Q2GQS3">
        <property type="interactions" value="1062"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GQS3"/>
    <dbReference type="GeneID" id="4396439"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09681"/>
    <dbReference type="eggNOG" id="KOG1914">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007630_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GQS3"/>
    <dbReference type="OMA" id="VQLWSVY"/>
    <dbReference type="OrthoDB" id="26282at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="6">
        <location>
            <begin position="141"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="534"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="781"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="836"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="935"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="993"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="855"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="996"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ83277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1013" mass="113790" checksum="F49C5E62AB1D6A9B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQV7</accession>
    <name>Q2GQV7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_09647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227574.1">
        <property type="nucleotide sequence ID" value="XM_001227573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQV7"/>
    <dbReference type="GeneID" id="4396073"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09647"/>
    <dbReference type="HOGENOM" id="CLU_1927355_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQV7"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ83243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="131" mass="14531" checksum="3B4610CDC169319A" modified="2006-03-21" version="1">MGCVGYTTAGPTQIPYSAEAVTGDGPWISSYNSSFEPSGSRRGHPRLSPTLNRYFGLRPFTSIMDVDCGFDIFPRLDAADEADRPAYQQFLGEIIDTYKDPHGEKGSWEERKVLQLPAGDSGGYFGDRVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GR22</accession>
    <name>Q2GR22_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_09582</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227509.1">
        <property type="nucleotide sequence ID" value="XM_001227508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GR22"/>
    <dbReference type="STRING" id="306901.Q2GR22"/>
    <dbReference type="GeneID" id="4396983"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09582"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1104957_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GR22"/>
    <dbReference type="OMA" id="YWRYIND"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF6">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208093" description="SET domain-containing protein" evidence="2">
        <location>
            <begin position="34"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="149"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ83178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="307" mass="34882" checksum="708B9ACC5D924EED" modified="2006-03-21" version="1">MVVSMRSWRNQRGSRIRILLLLALFIHFRPLGALKQKPMRDWTVCSWDAYVGPLVLQSQERACPLTNDWSLWSHQPICPGPVGDDYNSEPFSPDCVFTLTTFRGNQGISLITTPQLAANLADKLDDSRVSPSSRSQLTNTGQVQRDGEAPYEVREIPGRGKGVLAKRKYREHKTVMVGFPVLMVRLDFINEDRYGTRQKQYMMQASVRQLPPEQRESIQALARSTGGEPILDALRTNGFGVEIDGVQHLALFIDGSRVNHNCRPNSYWRYINDEMAMEVVALRDIQPGQEVAHSCKSRLQPMDNLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRT2</accession>
    <name>Q2GRT2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_09322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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            <begin position="78"/>
            <end position="87"/>
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            <end position="105"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
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    <sequence length="592" mass="67072" checksum="ED314A1367ED3101" modified="2006-03-21" version="1"> </sequence>
</entry>
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Untereiner W.A."/>
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            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <end position="59"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ85138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
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</entry>
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    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <begin position="358"/>
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        </location>
    </feature>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ85131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="389" mass="43084" checksum="B3EAC0EA20820FC1" modified="2006-03-21" version="1">MCCSTRTRHVHLTELHIIQGKVLTSKSGTLAYLAPEVYAGQGYDVRADWWSLGVLFYECIYNKRPFEGSSESSLSTVIQAARPKFPVTSPPVSLPCMYAIKDALDADPNKRLGSTWESFTQHEFFSCIDFVALERKEIEPVFVPSSEKTNFDATYDLEELLLEEAPLEARARRQKPRERLKDDATDKEIREDELYRMIDTDFRPFDYTVAAYKKITQQKERLSTGLEIFAGSKANLQPHALTTNEATPSPTSNGATTSRPSNENTTTTSNSSSTKQKQQQRRGNPPPGRSAPLAPYPQSYTPNAGSGGRAGRAFAPGMMVGSPTGGVQVTLDGGSSWSDLARQDATLPADASGANNEPGKDGARRRLLGRERERRRRLWLPAREEGQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSS3</accession>
    <name>Q2GSS3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 21</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">CHGG_08981</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001226907.1"/>
    </dbReference>
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    <dbReference type="STRING" id="306901.Q2GSS3"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08981"/>
    <dbReference type="eggNOG" id="ENOG502SPD4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009400_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GSS3"/>
    <dbReference type="OMA" id="PRPDWAM"/>
    <dbReference type="OrthoDB" id="5386574at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021582">
        <property type="entry name" value="Aim21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11489">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="797"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="867"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="970" mass="104905" checksum="F14B70F006373FF4" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GST3</accession>
    <name>Q2GST3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">General negative regulator of transcription subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_08971</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226898.1">
        <property type="nucleotide sequence ID" value="XM_001226897.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2GST3">
        <property type="interactions" value="1112"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GST3"/>
    <dbReference type="GeneID" id="4395382"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08971"/>
    <dbReference type="eggNOG" id="KOG1831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000286_3_1_1"/>
    <dbReference type="InParanoid" id="Q2GST3"/>
    <dbReference type="OMA" id="IDEYHCY"/>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000012">
        <property type="entry name" value="Ccr4-Not transcription complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.840:FF:000002">
        <property type="entry name" value="Ccr4-Not transcription complex subunit (NOT1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032194">
        <property type="entry name" value="CNOT1_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16418">
        <property type="entry name" value="CNOT1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 HEAT repeat" evidence="13">
        <location>
            <begin position="525"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="12">
        <location>
            <begin position="722"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="11">
        <location>
            <begin position="927"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="10">
        <location>
            <begin position="1203"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="9">
        <location>
            <begin position="1821"/>
            <end position="2189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ84957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="2193" mass="245869" checksum="D8CA82AFA7655962" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSU3</accession>
    <name>Q2GSU3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226888.1">
        <property type="nucleotide sequence ID" value="XM_001226887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSU3"/>
    <dbReference type="GeneID" id="4395890"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08961"/>
    <dbReference type="HOGENOM" id="CLU_1517702_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSU3"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="177" mass="18259" checksum="11A30E0E78C5E06A" modified="2006-03-21" version="1">MSGGWSRERIALVEEGLAFGGRMPSDTRAASALSSSSRGTGTKPAPGSAEREEVGDVGGMGRLGTGGAWPMGRRGIEGRPGASACEAATEVAAVKLLRRDVLRVRMPSLGGGVGLRLGRPNGDGHEDIRNGEVRKFERAELVELAPSAIAFITKADGIEANLGDHSEVVLPGQATTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GT56</accession>
    <name>Q2GT56_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BPL/LPL catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_08848</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226775.1">
        <property type="nucleotide sequence ID" value="XM_001226774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GT56"/>
    <dbReference type="FunCoup" id="Q2GT56">
        <property type="interactions" value="104"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GT56"/>
    <dbReference type="GeneID" id="4395830"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08848"/>
    <dbReference type="eggNOG" id="KOG1536">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006150_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GT56"/>
    <dbReference type="OMA" id="HHAFYSN"/>
    <dbReference type="OrthoDB" id="10250105at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin--[biotin carboxyl-carrier protein] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03144">
        <property type="entry name" value="GATase1_ScBLP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019197">
        <property type="entry name" value="Biotin-prot_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835">
        <property type="entry name" value="BIOTIN PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835:SF5">
        <property type="entry name" value="BIOTIN--PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09825">
        <property type="entry name" value="BPL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="396"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ84834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="680" mass="74362" checksum="9F20C4D7300123AB" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTP0</accession>
    <name>Q2GTP0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phospholipase D1</fullName>
            <ecNumber evidence="3">3.1.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Choline phosphatase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Phosphatidylcholine-hydrolyzing phospholipase D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_08664</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="3"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226591.1">
        <property type="nucleotide sequence ID" value="XM_001226590.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2GTP0">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GTP0"/>
    <dbReference type="GeneID" id="4395485"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08664"/>
    <dbReference type="eggNOG" id="KOG1329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000690_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GTP0"/>
    <dbReference type="OMA" id="DSLWTKH"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01254">
        <property type="entry name" value="PH_PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000011">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="897"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="1201"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="47"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="156"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="267"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="509"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="711"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1302"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1435"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1572"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1625"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="549"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1339"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1351"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1370"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1586"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1634"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1665"/>
            <end position="1678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1684"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1706"/>
            <end position="1723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ84650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1811" mass="202849" checksum="F7DE98FF027E14D0" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU96</accession>
    <name>Q2GU96_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U4/U6 snRNA-associated-splicing factor PRP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_08458</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a recycling factor of the spliceosome, a machinery that forms on each precursor-messenger RNA (pre-mRNA) and catalyzes the removal of introns. Chaperones the re-annealing of U4 and U6 snRNAs (small nuclear RNAs) released from previous rounds of splicing, an initial step in reforming the U4/U6-U5 tri-snRNP (small nuclear ribonucleoprotein) that can reassemble into another spliceosome complex; this step involves binding U6 and facilitating the unwinding of the U6 internal stem loop, followed by base-pairing of U6 to U4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226385.1">
        <property type="nucleotide sequence ID" value="XM_001226384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GU96"/>
    <dbReference type="STRING" id="306901.Q2GU96"/>
    <dbReference type="GeneID" id="4395380"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08458"/>
    <dbReference type="eggNOG" id="KOG0128">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003925_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GU96"/>
    <dbReference type="OMA" id="LWARYIL"/>
    <dbReference type="OrthoDB" id="360390at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12296">
        <property type="entry name" value="RRM1_Prp24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000365">
        <property type="entry name" value="U4/U6 snRNA-associated-splicing factor PRP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034397">
        <property type="entry name" value="Prp24_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031766">
        <property type="entry name" value="RRM_occluded"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16842">
        <property type="entry name" value="RRM_occluded"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="606"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="680"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="772"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="521"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="856"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="988"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1068"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="585"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="862"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="988"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1004"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1019"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1107"/>
            <end position="1123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ84444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1144" mass="125684" checksum="09D15A2B26064ECA" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUG7</accession>
    <name>Q2GUG7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Beta-galactosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_08387</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226314.1">
        <property type="nucleotide sequence ID" value="XM_001226313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUG7"/>
    <dbReference type="STRING" id="306901.Q2GUG7"/>
    <dbReference type="GeneID" id="4394705"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08387"/>
    <dbReference type="eggNOG" id="KOG2024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006501_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GUG7"/>
    <dbReference type="OMA" id="WYDTITR"/>
    <dbReference type="OrthoDB" id="408532at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032311">
        <property type="entry name" value="DUF4982"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048229">
        <property type="entry name" value="GalB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051913">
        <property type="entry name" value="GH2_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040605">
        <property type="entry name" value="Glyco_hydro2_dom5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041463">
        <property type="entry name" value="GalB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16355">
        <property type="entry name" value="DUF4982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18565">
        <property type="entry name" value="Glyco_hydro2_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208633" description="Beta-galactosidase" evidence="4">
        <location>
            <begin position="17"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="9">
        <location>
            <begin position="121"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="5">
        <location>
            <begin position="222"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="6">
        <location>
            <begin position="342"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4982" evidence="7">
        <location>
            <begin position="674"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2" evidence="8">
        <location>
            <begin position="746"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ84373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="853" mass="93037" checksum="1D47682693E046F1" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV44</accession>
    <name>Q2GV44_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UPF3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_08160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RENT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225816.1">
        <property type="nucleotide sequence ID" value="XM_001225815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV44"/>
    <dbReference type="STRING" id="306901.Q2GV44"/>
    <dbReference type="GeneID" id="4393540"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08160"/>
    <dbReference type="eggNOG" id="KOG1295">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018549_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GV44"/>
    <dbReference type="OMA" id="TVEFATY"/>
    <dbReference type="OrthoDB" id="18087at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12455">
        <property type="entry name" value="RRM_like_Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000637">
        <property type="entry name" value="Nonsense-mediated mRNA decay protein Upf3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039722">
        <property type="entry name" value="Upf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005120">
        <property type="entry name" value="UPF3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112:SF0">
        <property type="entry name" value="FI21285P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112">
        <property type="entry name" value="UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03467">
        <property type="entry name" value="Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF3" evidence="6">
        <location>
            <begin position="34"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="236"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="269"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="454"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="566"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="592"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ86907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="654" mass="67988" checksum="D8985D9EE271948B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-05" modified="2025-06-18" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV75</accession>
    <name>RSSA_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">40S ribosomal protein S0</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">RPS0</name>
        <name type="ORF">CHGG_08129</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225785.1">
        <property type="nucleotide sequence ID" value="XM_001225784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV75"/>
    <dbReference type="SMR" id="Q2GV75"/>
    <dbReference type="FunCoup" id="Q2GV75">
        <property type="interactions" value="1111"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GV75"/>
    <dbReference type="GeneID" id="4394490"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08129"/>
    <dbReference type="eggNOG" id="KOG0830">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058171_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GV75"/>
    <dbReference type="OMA" id="VKNFFEP"/>
    <dbReference type="OrthoDB" id="414863at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000010">
        <property type="entry name" value="40S ribosomal protein S0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000371627" description="Small ribosomal subunit protein uS2">
        <location>
            <begin position="1"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="293" mass="31735" checksum="F49A965809F4E08F" modified="2006-03-21" version="1">MAPANLPSIFNATSTDIEQLLAAQCHVGSKNLGVNMQPYLWKTRADGVNVINIGKTWEKITLAARIIAAIDNPSDVCVISARPYGQRAVLKFAAHTGAQAIAGRFTPGSFTNYITRSFKEPRLIIVTDPRTDSQAIKEASYVNIPVIALCDTDSPTEYVDVAIPTNNKGRHSIGLVWWMLAREVLRLRGTIYNRETPWDVMPDLYFYRDPEAEAEEKVEEEKVPGVEEEGPVAIESGFPAGGADWEAAPAGFPAAATGEWSEAQPATWESGAAAATGPSTEWADSAPKDTAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVJ6</accession>
    <name>Q2GVJ6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial carrier protein PET8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225664.1">
        <property type="nucleotide sequence ID" value="XM_001225663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVJ6"/>
    <dbReference type="GeneID" id="4393481"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08008"/>
    <dbReference type="eggNOG" id="ENOG502SEH2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121514_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GVJ6"/>
    <dbReference type="OMA" id="ETHERHK"/>
    <dbReference type="OrthoDB" id="529205at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13293" checksum="3CC63211242BFB27" modified="2006-03-21" version="1">MSARALFNTTTKALRPSILSLPNTTARRTLTQTPRVALKESASTDPDATNYEHHKQDSLAKQKKGEGHWKPELASVSEESVKADRMGPQEAGEAAMKRLQEQTKGRAEETSKKGTSMRDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVR5</accession>
    <name>Q2GVR5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_07939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225595.1">
        <property type="nucleotide sequence ID" value="XM_001225594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVR5"/>
    <dbReference type="GeneID" id="4394189"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07939"/>
    <dbReference type="HOGENOM" id="CLU_1594330_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GVR5"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ86686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="167" mass="18208" checksum="EABCBC74DB5A5D12" modified="2006-03-21" version="1">MAFRSPPKTPASAFRRWAAAAASWAGRRGGATRSDSRWVVHSRSCRRVSEVSGRVCGRSMQVPDGPWTVWALAHPGGVLDEGEVGPCHLVEHDDAGEVGLGGDEAVQVFQRRCHARVVLGPHEVDVPGEHGELERSRRCGGPPGNRWLRRLDRAPEPVPEGVVLLWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVW5</accession>
    <name>Q2GVW5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_07889</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225545.1">
        <property type="nucleotide sequence ID" value="XM_001225544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVW5"/>
    <dbReference type="STRING" id="306901.Q2GVW5"/>
    <dbReference type="GeneID" id="4393728"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07889"/>
    <dbReference type="eggNOG" id="KOG1612">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1434291_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GVW5"/>
    <dbReference type="OrthoDB" id="272245at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ86636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="189" mass="20438" checksum="4DF17D978391C42B" modified="2006-03-21" version="1">MASSQHVLLSPAELAYLHASLSLAPPIRPDGRSPTQFRPLVAETGILPGTNGSARICFADGTEAIVGVKAEVERTAQRPGEDTVFFEEGGAGSDDVDEEGETREGVDKRKGDASWVEMTVEIPGLRDDDSGTAFLSAMLSEALLADGEFAKRLWINRRFHWKLYLDVRPALSCLAPPTLPYLTLPPTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVW6</accession>
    <name>Q2GVW6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_07888</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225544.1">
        <property type="nucleotide sequence ID" value="XM_001225543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVW6"/>
    <dbReference type="FunCoup" id="Q2GVW6">
        <property type="interactions" value="907"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GVW6"/>
    <dbReference type="GeneID" id="4393727"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07888"/>
    <dbReference type="eggNOG" id="KOG0533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052367_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GVW6"/>
    <dbReference type="OMA" id="NEFGPIK"/>
    <dbReference type="OrthoDB" id="346839at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140746">
        <property type="term" value="P:siRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF35">
        <property type="entry name" value="RNA ANNEALING PROTEIN YRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="70"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="166"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ86635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="250" mass="25856" checksum="FA7DBF15C106F6FE" modified="2006-03-21" version="1">MSGKLDQTLDEILTSQRRNQQGRRRSTRRTAGTTRPAPAAPAGGIQKSTKPARGANKPTPTRAGGVTGESKIMVSNLPKDVSEAQIKEYFVQSVGQVKKVEISYGPGGVSRGIAHVSFQQADGASKAFATLNGLLIDSKPVKVEVVVASADLIPQPKSLAQRIAQPKAQPKSAAAVKKNATAGKGNAAASKGAKKTARGGRSNRVVKKTVEELDSEMADYFVGGNTDNNANAAAPPAAAGGDAAMEEDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWN7</accession>
    <name>Q2GWN7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_07617</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225273.1">
        <property type="nucleotide sequence ID" value="XM_001225272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWN7"/>
    <dbReference type="STRING" id="306901.Q2GWN7"/>
    <dbReference type="GeneID" id="4394280"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07617"/>
    <dbReference type="eggNOG" id="ENOG502RS9N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_407676_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWN7"/>
    <dbReference type="OMA" id="YAHARHE"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="579"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="457"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="601"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="499"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="606"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="644"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="656"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ86364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="674" mass="72207" checksum="78983B8DF2DA305A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWT9</accession>
    <name>Q2GWT9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_07565</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays a key role in the late stages of endoplasmic reticulum to Golgi traffic.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit TRAPP (transport protein particle) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225221.1">
        <property type="nucleotide sequence ID" value="XM_001225220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWT9"/>
    <dbReference type="FunCoup" id="Q2GWT9">
        <property type="interactions" value="316"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GWT9"/>
    <dbReference type="GeneID" id="4393416"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07565"/>
    <dbReference type="eggNOG" id="KOG3315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073154_2_1_1"/>
    <dbReference type="InParanoid" id="Q2GWT9"/>
    <dbReference type="OMA" id="YMVKFDD"/>
    <dbReference type="OrthoDB" id="10254842at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000007">
        <property type="entry name" value="Trafficking protein particle complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017479">
        <property type="entry name" value="TRAPP_I_complex_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ86312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="218" mass="24403" checksum="D104CDE4C3675F53" modified="2006-03-21" version="1">MAHLGPGKTASSKEQTGLRYPSNGKTIYHRPLNRTKAAELSQSSFAYLFSEMVTYAQRRVTGIQELEKRLNVQGHPIGLKLLDLLLMREPPRTQTRPLTIIALLHFIKINLWTHLFGRQADRLEKSSNPDTPDEYMIVDNEPVVNAYISVPREMSQLNCAAFIAGIIEGVCDGAMFPARVTAHSVGGKEEGEMWPGKTVFLVKFQPEILEREALLGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWX8</accession>
    <name>Q2GWX8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Conidiation-specific protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225182.1">
        <property type="nucleotide sequence ID" value="XM_001225181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWX8"/>
    <dbReference type="GeneID" id="4393614"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07526"/>
    <dbReference type="HOGENOM" id="CLU_107705_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GWX8"/>
    <dbReference type="OrthoDB" id="5419162at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018824">
        <property type="entry name" value="Conidiation-specific_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052670">
        <property type="entry name" value="UPF0654_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576:SF2">
        <property type="entry name" value="PROTEIN CON-6, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03615)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576">
        <property type="entry name" value="UPF0654 PROTEIN C11D3.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10346">
        <property type="entry name" value="Con-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11269" checksum="4E4CE53F3BDB8CE9" modified="2006-03-21" version="1">MEEPQAAQPKRRSSSSKKSSSTGPHSHSTGSQAPQAHSSGVEKGQPGGRKARRASVGEAGDAQMTEEKDRGNVIRGLKAALKNPHVSEQAKEADRKKLRDLGETVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX21</accession>
    <name>Q2GX21_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase T2-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_07483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225139.1">
        <property type="nucleotide sequence ID" value="XM_001225138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX21"/>
    <dbReference type="GeneID" id="4393507"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07483"/>
    <dbReference type="eggNOG" id="ENOG502R6SE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126139_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GX21"/>
    <dbReference type="OrthoDB" id="4671383at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057328">
        <property type="entry name" value="RNaseT2L_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25488">
        <property type="entry name" value="RNaseT2L_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208252" description="RNase T2-like C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="RNase T2-like C-terminal" evidence="2">
        <location>
            <begin position="36"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ86230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="173" mass="18223" checksum="59332C7768886B22" modified="2006-03-21" version="1">MRSSNPLLLLLPLLATLTTALPATTPLPPTARSTASFTGRGQIRTLWNQGDYADLGCLTAAGLWTTNNALCGTFTGTALTTSSLPTFTLSSSAGPCHVYGAQFKCEQGVVGFEFGIWPWPNSIPGKDCLRYGQYGLMASSGVGGPPAAGTAIDVHFVSYSEQGKYVWLTWAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXE3</accession>
    <name>Q2GXE3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225017.1">
        <property type="nucleotide sequence ID" value="XM_001225016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXE3"/>
    <dbReference type="ESTHER" id="chagb-q2gxe3">
        <property type="family name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="GeneID" id="4393559"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07361"/>
    <dbReference type="eggNOG" id="ENOG502S3GI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066049_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GXE3"/>
    <dbReference type="OMA" id="KLGWEQY"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="279" mass="30175" checksum="CC0E7C83104495B1" modified="2006-03-21" version="1">MGSNSMFDEQPSLIQIFDPDTAPTPTPPTPLVLIHDGGGTIFSYHCLGELGRTVHGIANPHYESAQPWAGGIPEMARQYLAYVESVIAPGGEVILGGWSLGGLLALEMAAQAAAADQGRRIRVVGILMVDSVCPVAPAEGAPRPALVVPHAVQWHEHTRPETREKVTWCFAEAVRMVGEWTLPVWEGKAGGGPSPPPVVMLRARERVPVEVGVSRVDLHRSDRLLGWGGYRKDLIKEIIDIPGHHYNVFDTEDNLDAATEAIMTACSVIERLDASRAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXK9</accession>
    <name>Q2GXK9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224951.1">
        <property type="nucleotide sequence ID" value="XM_001224950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXK9"/>
    <dbReference type="GeneID" id="4394293"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07295"/>
    <dbReference type="eggNOG" id="ENOG502RJYI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_652115_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GXK9"/>
    <dbReference type="OMA" id="PARESIY"/>
    <dbReference type="OrthoDB" id="3902588at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="421" mass="45622" checksum="EBD2FC38CF8BB5C4" modified="2006-03-21" version="1">MFEVDWQDYGCERVGQRRVRKEVEKEQKKNNDASSGHRTNSTLSTRTSSSSDQNHRKFFGSIGRKKPAASLKNNEPEATTPKVESTQANGTFKRSSLRFSGITTTMMAPPTANISTGLENKPLNIQPSGTLRNIADAMQSNSPQSADRSMTQLTVPTLESQGDEPTNDATTEIKLVQALDDKGSSVNKVVTTTYEHGEADPFVSTRSGVGTQITAGFKIPRKTGLSRAIHPAPSPADDAKSASELIDDWFIALHNPAARPALKPGPNGTFRSGGVLLPPNVVRRTLPETPTRQSAKNSDAGFLPARLTPIRFSADNPDDWTPVAQRKRAPSDSVRAPPAPVENQESVQGEEEVMRLMAADLKDIHIQEEVARESGTARSNADTPRAKRSAGYAVEPGPRSAPMEKNAETVRKSGRPVRPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYE2</accession>
    <name>Q2GYE2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA endonuclease activator Ctp1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_07012</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224668.1">
        <property type="nucleotide sequence ID" value="XM_001224667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYE2"/>
    <dbReference type="STRING" id="306901.Q2GYE2"/>
    <dbReference type="GeneID" id="4394100"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07012"/>
    <dbReference type="eggNOG" id="ENOG502S92Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018738_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYE2"/>
    <dbReference type="OMA" id="HRFSRMQ"/>
    <dbReference type="OrthoDB" id="5801062at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013882">
        <property type="entry name" value="Ctp1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08573">
        <property type="entry name" value="SAE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA endonuclease activator Ctp1 C-terminal" evidence="6">
        <location>
            <begin position="567"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="387"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="504"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="13"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="540"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ85759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="714" mass="80219" checksum="6A691336238717B9" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYE3</accession>
    <name>Q2GYE3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_07011</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224667.1">
        <property type="nucleotide sequence ID" value="XM_001224666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYE3"/>
    <dbReference type="FunCoup" id="Q2GYE3">
        <property type="interactions" value="707"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GYE3"/>
    <dbReference type="MEROPS" id="C19.A57"/>
    <dbReference type="GeneID" id="4394099"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07011"/>
    <dbReference type="eggNOG" id="KOG1871">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008279_3_0_1"/>
    <dbReference type="InParanoid" id="Q2GYE3"/>
    <dbReference type="OMA" id="AMIMFMK"/>
    <dbReference type="OrthoDB" id="429671at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
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        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="485"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="185"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="617"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="818"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
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        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
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        <location>
            <begin position="617"/>
            <end position="635"/>
        </location>
    </feature>
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        <location>
            <begin position="834"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ85758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="915" mass="98681" checksum="60CA4F3D98B3F35A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYZ5</accession>
    <name>Q2GYZ5_CHAGB</name>
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        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">CHGG_05251</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EAQ88632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="4392773"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05251"/>
    <dbReference type="eggNOG" id="KOG2533">
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    <dbReference type="OMA" id="EDSKRIC"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF16">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="313"/>
        </location>
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        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ88632.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="51819" checksum="FD409115E44E26A3" modified="2006-03-21" version="1">MRSDLKTDVKIGCVAVEDATPEAATDPRVVLTEEDVLDKITLGLSALFGLREDTHLVGNQYSVLAAAAPIAQLAWQPVSSVLIVKIRHRVLMPAMILGWGLFEAGCLPLFSIITSQWYRRSEQPIRVALWFGTNGLATMVAAILSYGLGRIESTVLAPWQWIYLVTGLLTIISVPFIYWRLDDDIRTARFLTPEERAQALERLRANQTGAGTQEYQWKQVLETFTDIKCYLFGAMSLAICIGAQMAVTFGPLILKSFGFDTYKTTLLNIPFGALQCIVVLSAAWVTVRTRWKSLALGFMLVFILVGLVLLYTLPRDKSHIPGLLLAYYFLAFIFGCVNLIVSWILANTAGQTKKSTMMAVFNAAASVGAIVGPLLFDAADAPEYRAGIRSTMGVFAGMFAIVLLQVGNLMLLNKLQVRRRIANNKPAHIHDHSMDDKYVDIRTGNAGTTGDRAFAGLTDRDNDEFVYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZA9</accession>
    <name>Q2GZA9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224351.1">
        <property type="nucleotide sequence ID" value="XM_001224350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZA9"/>
    <dbReference type="GeneID" id="4393112"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05137"/>
    <dbReference type="eggNOG" id="ENOG502RKGT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1062390_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZA9"/>
    <dbReference type="OrthoDB" id="5233988at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208627" evidence="2">
        <location>
            <begin position="19"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="263" mass="27507" checksum="B683DF72FDD6DC54" modified="2006-03-21" version="1">MELLMLFLLSTALVPVSSSPARRADRSEPFHLAISTTVAGGSPAGHGPSTPTVAPAIELRADNGAAAEPVLGRREALNIGDPNASPADTVILHPWPGQACTTTLSETFGYPCSWDGTTTMYPSTTILFQQINCNGCSSVYVSKDYYYCPNQSINATLRAGIPSTSWSTICQQSTGVAKRTEVDAPAATTPTAESGPKAVRSPEDGVHPAACPTTLVVQPVRSAGKTATTYASFTTTTSTVNCGGCPLVRVGRVEERAVEILFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H019</accession>
    <name>Q2H019_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_04877</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224091.1">
        <property type="nucleotide sequence ID" value="XM_001224090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H019"/>
    <dbReference type="STRING" id="306901.Q2H019"/>
    <dbReference type="GeneID" id="4392943"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04877"/>
    <dbReference type="eggNOG" id="ENOG502RKIP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2037792_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H019"/>
    <dbReference type="OrthoDB" id="4588272at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044249">
        <property type="entry name" value="XERICO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47258">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47258:SF7">
        <property type="entry name" value="RING-H2 FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="57"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ88258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="121" mass="13251" checksum="BF68279EF906AD62" modified="2006-03-21" version="1">MVRIISGGLLGLGYNNYGLAMEQPQSGQYDIRGSVVVWVTGGLLITAIVLIAVRTFICLDGFEDESLVSSLPCYHVFHAVCIRNWFQTRRDTCPLCKARVPSGSQVETVLPTQPQRAVLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0N1</accession>
    <name>Q2H0N1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223879.1">
        <property type="nucleotide sequence ID" value="XM_001223878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0N1"/>
    <dbReference type="GeneID" id="4391788"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04665"/>
    <dbReference type="eggNOG" id="ENOG502SSR4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087045_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H0N1"/>
    <dbReference type="OMA" id="YRREPLM"/>
    <dbReference type="OrthoDB" id="5423884at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="286" mass="31001" checksum="24FCDD7D80C56C8F" modified="2006-03-21" version="1">MYPSLADRIVAALPVERVILIVPSAALSDLSALSPLFYHITSIDPNHIAHALIIPRQNPQDNPPPPPTHTTTIPAYYGSLTGSPDPGAVAGITLGAVAGFVLLLWLVYTCINLGNPGAVGGGAGDTSTVVTEGSGSVYTRRRGQRSRSRRRSSRHQHKETVEVRRGGVTVRGGPVVVEEVVSSSMAPSEFDRVVVQEERRRRSVSRARMAGAGPPPPRRVVSSSGEDDEDDEDEVVVIEEHSPSRRRRSRVRSVERRSSGFREVDPDRFAGGDASFMEVRRSGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0P9</accession>
    <name>Q2H0P9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223861.1">
        <property type="nucleotide sequence ID" value="XM_001223860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0P9"/>
    <dbReference type="GeneID" id="4391691"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04647"/>
    <dbReference type="eggNOG" id="ENOG502RJCT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1786623_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H0P9"/>
    <dbReference type="OrthoDB" id="4590603at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="145" mass="15177" checksum="09363923B9E3D28D" modified="2006-03-21" version="1">MPPEDLLRGLIEDTDLNNDTTNNALQGLKRPHDDETADEPLAKRDKLGEELDRLFALNPSPVSATASSGSATFSISAAAAYPSPIDGPSIGGPPGPTVPSRTRGTLPIRAARRRLPRVGNGTVMSRSGIPETSEPASSSDNDSEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0T0</accession>
    <name>Q2H0T0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223830.1">
        <property type="nucleotide sequence ID" value="XM_001223829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0T0"/>
    <dbReference type="STRING" id="306901.Q2H0T0"/>
    <dbReference type="GeneID" id="4391604"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04616"/>
    <dbReference type="eggNOG" id="ENOG502QURC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062644_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H0T0"/>
    <dbReference type="OMA" id="DAGYQHT"/>
    <dbReference type="OrthoDB" id="891726at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007541">
        <property type="entry name" value="Uncharacterised_BSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321:SF12">
        <property type="entry name" value="PLANT BASIC SECRETORY PROTEIN (BSP) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04450">
        <property type="entry name" value="BSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="266" mass="29911" checksum="8D88481B635D3BAF" modified="2006-03-21" version="1">MAIKEQPSVPAPSPIPLPDRTRDTTERGPGPVSESSTGQSFSKPKLRLKIQDLDHPGAAKFLNSVNSATVLSTAVNNVLRLLYKSPSEKHTTVPPTRSVTLVLRDMGGVAYTTGFLLTQLPLLHPTRKTDLDNDHKEIHFSLNYINSINPVSRLTHEITGVLTHELVHCYQWDAEGTCPGGLIEGVADWVRLNCDLSPPHWKKEVEGAYFLQYLEQRFGEGTIRRLNDELRRHKYECEAFWPGLLGRSVEKLYGDYVKKEKDDGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0V7</accession>
    <name>Q2H0V7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor SYF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pre-mRNA-splicing factor syf1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_04589</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223803.1">
        <property type="nucleotide sequence ID" value="XM_001223802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0V7"/>
    <dbReference type="FunCoup" id="Q2H0V7">
        <property type="interactions" value="930"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H0V7"/>
    <dbReference type="GeneID" id="4392195"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04589"/>
    <dbReference type="eggNOG" id="KOG2047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007736_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H0V7"/>
    <dbReference type="OMA" id="IWYNYLR"/>
    <dbReference type="OrthoDB" id="10067343at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000666">
        <property type="entry name" value="DNA repair and transcription protein (Xab2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000023">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000038">
        <property type="entry name" value="Putative pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="15">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor SYF1 central HAT repeats" evidence="13">
        <location>
            <begin position="72"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="14">
        <location>
            <begin position="287"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="692"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAQ87970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="711" mass="82572" checksum="70514DAC2F6467DD" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1U9</accession>
    <name>Q2H1U9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_04247</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223461.1">
        <property type="nucleotide sequence ID" value="XM_001223460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1U9"/>
    <dbReference type="GeneID" id="4391758"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04247"/>
    <dbReference type="eggNOG" id="ENOG502SF40">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018830_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H1U9"/>
    <dbReference type="OMA" id="PFNDPVN"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="343"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="17"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="205"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="397"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ87628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="509" mass="53587" checksum="5770D787852C6F88" modified="2006-03-21" version="1">MAARELWVVVKREVRDMLAPGQAERRGAASPDSPPRINQRQDGTSTSLPPAVLPPAISRPPLDDADATSLALAPVATTTAASTTLVVAETSTSTPSSSATAEPSESDSGEISGAAKAGIVIGALAGILAIFVLVYLIFNSRRKKLARRRQQIEDDEKINGPFADSAEIRPVPPAKAPRLSLRPVTQFLPNFNAQHGERRQSRGIALTLNPVSNSALSRPTGGSAWERPTMASPHAPSARWAPSTTASASQRHPTQSQNRVSPILGDDEDDNRRQPSMVSNLTRKTSIRKDLPKPLDLTKPPSPLYAMPPSPSGTEFSMHSVAPGQSPGPSASAAAIAAAGGPSQSTVHRVQLDFKPTLQDEMGLYAGQLVRLLHEYDDGWALCIRLDRSQQGVVPRTCLSTRPVKPRPQQQQPGPPHANHSGNQRGGPPINPSFHFGHGNGGQGSSRPRSPAGGGGGGGGGAFPPVPLAKDDRYGGRRAPSPRLQHGGWRGDGYDDGEGDVSPAPGQAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H226</accession>
    <name>Q2H226_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Rad4 beta-hairpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_04170</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223384.1">
        <property type="nucleotide sequence ID" value="XM_001223383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H226"/>
    <dbReference type="STRING" id="306901.Q2H226"/>
    <dbReference type="GeneID" id="4392142"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04170"/>
    <dbReference type="eggNOG" id="KOG2179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003639_0_2_1"/>
    <dbReference type="InParanoid" id="Q2H226"/>
    <dbReference type="OMA" id="TWPGKTK"/>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2460:FF:000001">
        <property type="entry name" value="DNA repair protein Rad4 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
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        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="7">
        <location>
            <begin position="549"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="608"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="678"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="377"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="800"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="846"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="856"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="921"/>
            <end position="934"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ87551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="934" mass="105199" checksum="B57E5139BE99D398" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2K9</accession>
    <name>Q2H2K9_CHAGB</name>
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        <recommendedName>
            <fullName evidence="3">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">CHGG_03987</name>
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    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="5244787at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ87368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="20524" checksum="E199D0F993F48258" modified="2006-03-21" version="1">MYGGSNTKEVVELAWQARWEQQRASQQSTTRQRVLNRRIADEDPPALLFTDKALMRHEGLTKAQSSLLSQARIGDIGLRDYLFRVKVPEVRTPYCECGRGRETVEHLVVWCPDPPLQRPWDGREIRSHRDLQTVLRGVGARSRRFVRKVLGWLMDSGRLLEYRLARRLELETVDGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2W9</accession>
    <name>Q2H2W9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_03877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223091.1">
        <property type="nucleotide sequence ID" value="XM_001223090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2W9"/>
    <dbReference type="GeneID" id="4391899"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03877"/>
    <dbReference type="HOGENOM" id="CLU_2196647_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2W9"/>
    <dbReference type="OrthoDB" id="10483604at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ87258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="108" mass="12447" checksum="5D59A5CE57175F83" modified="2006-03-21" version="1">MCYILSGTAVEANLRGQWTQRWANLRDRAGKLGNPAETIRYLHIIRNIHRAAFDLARTELRGLGAYDADYAQERRQQILYSIFDDVYGAEDYMLVEELTPVMSRQPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3F8</accession>
    <name>Q2H3F8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">beta-glucosidase</fullName>
            <ecNumber evidence="16">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CHGG_06807</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="16"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222902.1">
        <property type="nucleotide sequence ID" value="XM_001222901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3F8"/>
    <dbReference type="STRING" id="306901.Q2H3F8"/>
    <dbReference type="GeneID" id="4391259"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06807"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H3F8"/>
    <dbReference type="OMA" id="VVMESWI"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF20">
        <property type="entry name" value="BETA-GLUCOSIDASE E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 16" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="19">
        <location>
            <begin position="881"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="778"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="782"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EAQ90188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="962" mass="104698" checksum="6364A3808CD3F63B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3G3</accession>
    <name>Q2H3G3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_06802</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222897.1">
        <property type="nucleotide sequence ID" value="XM_001222896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3G3"/>
    <dbReference type="STRING" id="306901.Q2H3G3"/>
    <dbReference type="GeneID" id="4391379"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06802"/>
    <dbReference type="eggNOG" id="KOG3076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038395_3_0_1"/>
    <dbReference type="InParanoid" id="Q2H3G3"/>
    <dbReference type="OMA" id="QILNIHH"/>
    <dbReference type="OrthoDB" id="4239773at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008864">
        <property type="term" value="F:formyltetrahydrofolate deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04875">
        <property type="entry name" value="ACT_F4HF-DF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08648">
        <property type="entry name" value="FMT_core_Formyl-FH4-Hydrolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01927">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041729">
        <property type="entry name" value="Formyl-FH4-Hydrolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004810">
        <property type="entry name" value="PurU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044074">
        <property type="entry name" value="PurU_ACT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004684">
        <property type="entry name" value="PRK06027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00655">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706">
        <property type="entry name" value="FORMYLTETRAHYDROFOLATE DEFORMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706:SF1">
        <property type="entry name" value="FORMYLTETRAHYDROFOLATE DEFORMYLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036480">
        <property type="entry name" value="FormyFH4_hydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01575">
        <property type="entry name" value="FFH4HYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="6"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ90183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="284" mass="31594" checksum="4DBFD173E797562E" modified="2006-03-21" version="1">MATDQILTLSCPDKPGIVHAVTGIFAREEHNILDLQQFSDPVSEKFFMRVHFGPSPRAAESTEHLRPIFDSLAEDYKMTYKIRPVSQKPRVLIMVSKIGHCLNDLLFRAKAGQLPIEIPLIVSNHPEFAALAASYGIEFHHLPVTKETKAVQEGQILDLIKKHSIELVVLARYMQVLSPTLCEAMSGRIINIHHSFLPSFKGAKPYHQAYDRGVKIIGATAHFVTADLDEGPIIEQRVARVDHSINPNGLVDEGSNIESQVLAAAVKWYAEGRVFLNGTKTVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4W2</accession>
    <name>Q2H4W2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CHGG_06303</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 21">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222398.1">
        <property type="nucleotide sequence ID" value="XM_001222397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4W2"/>
    <dbReference type="STRING" id="306901.Q2H4W2"/>
    <dbReference type="GeneID" id="4390674"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06303"/>
    <dbReference type="eggNOG" id="KOG0591">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="InParanoid" id="Q2H4W2"/>
    <dbReference type="OMA" id="AYFERDH"/>
    <dbReference type="OrthoDB" id="10250725at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08217">
        <property type="entry name" value="STKc_Nek2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000697">
        <property type="entry name" value="G2-specific protein kinase nimA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000525">
        <property type="entry name" value="Serine/threonine-protein kinase KIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="7"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="384"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="502"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="590"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="292"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="618"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAQ89684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="766" mass="84873" checksum="F52D47CB08293E03" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H595</accession>
    <name>Q2H595_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_06170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222265.1">
        <property type="nucleotide sequence ID" value="XM_001222264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H595"/>
    <dbReference type="STRING" id="306901.Q2H595"/>
    <dbReference type="GeneID" id="4390975"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06170"/>
    <dbReference type="eggNOG" id="KOG3872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021864_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H595"/>
    <dbReference type="OMA" id="VEHAGFM"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF46">
        <property type="entry name" value="TO VACUOLE TARGETING VPS64, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="194"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="558"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="514"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="558"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="594"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="617"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ89551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="684" mass="73750" checksum="23FF88712282FFD2" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5L8</accession>
    <name>Q2H5L8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222142.1">
        <property type="nucleotide sequence ID" value="XM_001222141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5L8"/>
    <dbReference type="GeneID" id="4390284"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06047"/>
    <dbReference type="eggNOG" id="ENOG502SKQE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028906_4_1_1"/>
    <dbReference type="InParanoid" id="Q2H5L8"/>
    <dbReference type="OMA" id="THNMTDM"/>
    <dbReference type="OrthoDB" id="5412996at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="525" mass="59076" checksum="E0057CDA2D5449A0" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5Z7</accession>
    <name>DENR_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Translation machinery-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">TMA22</name>
        <name type="ORF">CHGG_05918</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Interacts with the 40S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The SUI1 domain may be involved in RNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DENR family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222013.1">
        <property type="nucleotide sequence ID" value="XM_001222012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5Z7"/>
    <dbReference type="SMR" id="Q2H5Z7"/>
    <dbReference type="FunCoup" id="Q2H5Z7">
        <property type="interactions" value="1057"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H5Z7"/>
    <dbReference type="GeneID" id="4391426"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05918"/>
    <dbReference type="eggNOG" id="KOG3239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073511_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H5Z7"/>
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        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
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    </dbReference>
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        <property type="entry name" value="SUI1"/>
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    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000320439" description="Translation machinery-associated protein 22">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="SUI1" evidence="2">
        <location>
            <begin position="96"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="188" mass="20530" checksum="4F1F77ABCB2E61DA" modified="2006-03-21" version="1">MAEPTPVGREIIYCGVCTLPPEYCEYGGTTKKCQEWLEKKHPDLYARIWSPEALEAATASLSLAAQERAAKDAAKKAAKAEAAEQKHADKLAKSVVTIKRIERNKRKFVTSVTGLEAFGLELKKVAKDFGKKFATGASVTKVPSGGEEIVVQGDVSGEIEEFLLEKYKDIPEDNIELVEDKKKKASAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6N2</accession>
    <name>Q2H6N2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TRUD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_05683</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
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    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_001221777.1"/>
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    <dbReference type="SMR" id="Q2H6N2"/>
    <dbReference type="FunCoup" id="Q2H6N2">
        <property type="interactions" value="1036"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H6N2"/>
    <dbReference type="GeneID" id="4390369"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05683"/>
    <dbReference type="eggNOG" id="KOG2339">
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    <dbReference type="OMA" id="IGEYYVE"/>
    <dbReference type="OrthoDB" id="447290at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:pseudouridine synthase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd02576">
        <property type="entry name" value="PseudoU_synth_ScPUS7"/>
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        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="3"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="347"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="655"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="731"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="851"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="655"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="744"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ89064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="986" mass="109262" checksum="0E7E1DDC0D775A32" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6S9</accession>
    <name>Q2H6S9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_05636</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221731.1">
        <property type="nucleotide sequence ID" value="XM_001221730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6S9"/>
    <dbReference type="GeneID" id="4390072"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05636"/>
    <dbReference type="eggNOG" id="KOG2922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_327797_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6S9"/>
    <dbReference type="OMA" id="RCIVAVQ"/>
    <dbReference type="OrthoDB" id="165382at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF65">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="598"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="636"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="699"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="730"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="761"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="7">
        <location>
            <begin position="73"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="451"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="800"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="904"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="826"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="931"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="964"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ89017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="989" mass="108548" checksum="CFF4BD0E8CBE6380" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H748</accession>
    <name>Q2H748_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221612.1">
        <property type="nucleotide sequence ID" value="XM_001221611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H748"/>
    <dbReference type="GeneID" id="4390229"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05517"/>
    <dbReference type="HOGENOM" id="CLU_1992366_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H748"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="125" mass="13439" checksum="19463D7E9DD11CAA" modified="2006-03-21" version="1">MASLRQIPEADIAAASPREVGSTQAIDTPTIQPYISPAPSRNPSCSHHASPAPAQVSAELDGWDAVNEGPKNAKEYWKQAYAALRQPDLLKRKRNGDTENKPACHDYGRMQATGGACWQCPGPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7E1</accession>
    <name>Q2H7E1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PhnB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221519.1">
        <property type="nucleotide sequence ID" value="XM_001221518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7E1"/>
    <dbReference type="GeneID" id="4390843"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05424"/>
    <dbReference type="eggNOG" id="ENOG502SNVF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_22_1_1"/>
    <dbReference type="InParanoid" id="Q2H7E1"/>
    <dbReference type="OMA" id="EESQCGW"/>
    <dbReference type="OrthoDB" id="10255422at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009725">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33990:SF2">
        <property type="entry name" value="PHNB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33990">
        <property type="entry name" value="PROTEIN YJDN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021700">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhnB-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="166" mass="18742" checksum="E0C19855C14DD5CF" modified="2006-03-21" version="1">MPLSKLQLTTCLWFDGQAEEAANFYTSIFPNSKITHIQHYLPNGQELHRHEPGTVLIVEFELDGHRFVGLNGGPHFRFNEAISFQIDCADQDEVDYYWDKLAEGGDPAKQQCSWVADKYGVSWQVVPTALKRMMASDDKAAAGRATEVMMQSKKMVIADLEKAFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7K4</accession>
    <name>Q2H7K4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221456.1">
        <property type="nucleotide sequence ID" value="XM_001221455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7K4"/>
    <dbReference type="STRING" id="306901.Q2H7K4"/>
    <dbReference type="GeneID" id="4390426"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05361"/>
    <dbReference type="HOGENOM" id="CLU_2372589_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7K4"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="95" mass="10387" checksum="AC1C0686CDFBAF7F" modified="2006-03-21" version="1">MPSDMGPPLPLQEALELVKLPSVGEARRFMGTRAAYLPGSDFDMEDSPTFHKAAFGGHVYAQAALAAARTWRELEDEKGATPAQRLDLHHPTLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7M8</accession>
    <name>Q2H7M8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221432.1">
        <property type="nucleotide sequence ID" value="XM_001221431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7M8"/>
    <dbReference type="STRING" id="306901.Q2H7M8"/>
    <dbReference type="GeneID" id="4390665"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05337"/>
    <dbReference type="eggNOG" id="ENOG502S3UW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1834931_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7M8"/>
    <dbReference type="OMA" id="CEKGMEV"/>
    <dbReference type="OrthoDB" id="63935at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004074">
        <property type="term" value="F:biliverdin reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="14259" checksum="775BF4394FF98579" modified="2006-03-21" version="1">MTTQKTILFLGATGGVGLSALRRSLAAGHTCIALCRTPANLTAQLTNTTTKNNNTTTTTTLPPNLHIITGNAHNPSDLRACLTHPSTTSSGGSGVDIIVSSIGARPTLRGMSDPLVCEKGMEVLFGGVEGRVGSKGAETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7P5</accession>
    <name>Q2H7P5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_05320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221415.1">
        <property type="nucleotide sequence ID" value="XM_001221414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7P5"/>
    <dbReference type="GeneID" id="4391233"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05320"/>
    <dbReference type="HOGENOM" id="CLU_2793772_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7P5"/>
    <dbReference type="OrthoDB" id="10302525at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ88701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="68" mass="7623" checksum="4E00ED6BA3F32843" modified="2006-03-21" version="1">MDRRQGRPPPAYLIATAYSKSGSRLKPITVGSELGAAHGDKRLMELNGSWLISRLIPMSWTLMKRLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H806</accession>
    <name>Q2H806_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_03648</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230164.1">
        <property type="nucleotide sequence ID" value="XM_001230163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H806"/>
    <dbReference type="GeneID" id="4388996"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03648"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_7_0_1"/>
    <dbReference type="InParanoid" id="Q2H806"/>
    <dbReference type="OMA" id="YMVFDLA"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF73">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208919" description="Peptidase A1 domain-containing protein" evidence="5">
        <location>
            <begin position="23"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="502"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="56"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="535"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="550"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="610"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="334"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ91713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="659" mass="69466" checksum="8346F548006D79BD" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H851</accession>
    <name>Q2H851_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2 type master regulator of conidiophore development brlA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_03603</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230119.1">
        <property type="nucleotide sequence ID" value="XM_001230118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H851"/>
    <dbReference type="STRING" id="306901.Q2H851"/>
    <dbReference type="GeneID" id="4389653"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03603"/>
    <dbReference type="HOGENOM" id="CLU_993969_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H851"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ91668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="280" mass="30593" checksum="735216E758101DDB" modified="2006-03-21" version="1">MDDEEYYGGQLQGYSIQNQPTVDPQDTIVAGGSRLAVGLTIETDQHEDPTPSYATGYLCGNTATYFVGHEGIAAAEHVSQAMADVTSPNIWPVQEMGYPGTPFLSAEYGPHTVEDETQTASAHIGNQSSIEIPISYPSAENDFLSTIVTDQSSSSSPSPPSSPLSSHIEPGGDIVCTEGKCAQNPQRFRRPGDYNMHTKRHRLPYKCTFAGCRWGQRGKGFSQRRELEKHEKTHLAGLSFSCPVKSCSSSATREDNLVRHLKKTHGIKAKKADIASLYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H870</accession>
    <name>Q2H870_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_03584</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230100.1">
        <property type="nucleotide sequence ID" value="XM_001230099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H870"/>
    <dbReference type="STRING" id="306901.Q2H870"/>
    <dbReference type="GeneID" id="4389117"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03584"/>
    <dbReference type="eggNOG" id="KOG1164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_765039_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H870"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ91649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="362" mass="41034" checksum="8FCCFA1E8369884C" modified="2006-03-21" version="1">MGLGKRSNQVSVIDFGLAKEYRDPKTHSHIPYRSKKNLTGTALYASINTHLGVEQSRRDDMESLGYVMLYLCRGSLPWQGLEASTRDEKHSRIMEKKMSTPTDELCRGLPNEFAIYLNYARSLHFEDKPDYRYLRAIFRNLFIREGFRYDYIFDWTVYKHRENAQAIQKTAHHSVAFPLISLQKADKHGDGRTAQLARMGSSKRISTPHRGDSSNQRRTARTMTVATTMTMSPPNLHRVPTTETVGASGSRAGVGAAVGAGVPFGFAATENFFSSWEARKRRQVWYYAMCALCLFPFIAPLVYWGTFDAAPWRYTHGEAELLTRRQRWNILVVGVASAVAWLVVLVVLVTVTVIRKVGEGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8R2</accession>
    <name>Q2H8R2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_03392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229908.1">
        <property type="nucleotide sequence ID" value="XM_001229907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8R2"/>
    <dbReference type="GeneID" id="4389881"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03392"/>
    <dbReference type="HOGENOM" id="CLU_2637849_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8R2"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ91457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="77" mass="8168" checksum="EDCEED5932326101" modified="2006-03-21" version="1">MAQYMEMPKVYYLSISHSAPPSPIEVSPGGRIRRMALLVLALPPRTGSPLGPAALPVVPVVARWEIGASRVETGSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9C5</accession>
    <name>Q2H9C5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_03179</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229695.1">
        <property type="nucleotide sequence ID" value="XM_001229694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9C5"/>
    <dbReference type="FunCoup" id="Q2H9C5">
        <property type="interactions" value="855"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H9C5"/>
    <dbReference type="GeneID" id="4389311"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03179"/>
    <dbReference type="eggNOG" id="KOG0402">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141199_2_1_1"/>
    <dbReference type="InParanoid" id="Q2H9C5"/>
    <dbReference type="OMA" id="GPRYGRK"/>
    <dbReference type="OrthoDB" id="10258345at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000002">
        <property type="entry name" value="60S ribosomal protein L37a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_eL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003058">
        <property type="entry name" value="PRK03976.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ91244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="92" mass="10162" checksum="32DF69E367A646F8" modified="2006-03-21" version="1">MSKRTKKVGISGKYGTRYGASLRKLVKKQEVSQHARYTCTFCGKNTVRRSAVGIWNCKSCKKTMAGGAYTVATPAAAAMRSTLRRLREITEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HA53</accession>
    <name>Q2HA53_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GPI anchored serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_02901</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229417.1">
        <property type="nucleotide sequence ID" value="XM_001229416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HA53"/>
    <dbReference type="STRING" id="306901.Q2HA53"/>
    <dbReference type="GeneID" id="4389132"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02901"/>
    <dbReference type="eggNOG" id="ENOG502SGJX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067145_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HA53"/>
    <dbReference type="OMA" id="YSTITGP"/>
    <dbReference type="OrthoDB" id="3565477at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208985" description="GPI anchored serine-rich protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ90966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="23566" checksum="B31DF7431F64D71F" modified="2006-03-21" version="1">MRFALATVALAGAALAHGHEEEAQSTVYSTEYYTITSCAPEVPDCPATATVVTSSVVSLTTSTVYSTTTKTITDCPDTVSNCPADSTTVVTETVAVSTTVCPVEPTETPEQPEETATESPEEPEETETPEVPEPSGSFVEPPVVSSTLVTEAPACPTTSVKTIKTSITTVIPTIIYETVEVPCETAAPPQSTPSSVPTGTRPGGPIETAGAATFGASALFAAAAGLFALMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HA76</accession>
    <name>Q2HA76_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA2/NAM7 helicase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_02878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229394.1">
        <property type="nucleotide sequence ID" value="XM_001229393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HA76"/>
    <dbReference type="GeneID" id="4389215"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02878"/>
    <dbReference type="eggNOG" id="KOG1802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007214_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HA76"/>
    <dbReference type="OMA" id="SNIAVIC"/>
    <dbReference type="OrthoDB" id="5408263at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ90943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="618" mass="68793" checksum="FE0F08E053330287" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAF6</accession>
    <name>Q2HAF6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acylphosphatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_02798</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the acylphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229314.1">
        <property type="nucleotide sequence ID" value="XM_001229313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAF6"/>
    <dbReference type="STRING" id="306901.Q2HAF6"/>
    <dbReference type="GeneID" id="4389783"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02798"/>
    <dbReference type="HOGENOM" id="CLU_141932_4_1_1"/>
    <dbReference type="InParanoid" id="Q2HAF6"/>
    <dbReference type="OMA" id="WVAEICT"/>
    <dbReference type="OrthoDB" id="7961613at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="Acylphosphatase/BLUF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ90863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="67" mass="7877" checksum="DB38DAA5D191F20B" modified="2006-03-21" version="1">MVKRFTYHRAIEQDLTGWVEGEAQGEEDAITEFLNHLNNGPRHSRVVRLDKEDKEVVDGEVEFEIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAK8</accession>
    <name>Q2HAK8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_02746</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229262.1">
        <property type="nucleotide sequence ID" value="XM_001229261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAK8"/>
    <dbReference type="STRING" id="306901.Q2HAK8"/>
    <dbReference type="GeneID" id="4389142"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02746"/>
    <dbReference type="eggNOG" id="ENOG502S8YW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015602_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HAK8"/>
    <dbReference type="OMA" id="ECLKPGH"/>
    <dbReference type="OrthoDB" id="303107at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031213">
        <property type="term" value="C:RSF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028938">
        <property type="entry name" value="Rsf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296:SF3">
        <property type="entry name" value="DIKAR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296">
        <property type="entry name" value="REMODELING AND SPACING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="404"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="153"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="289"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="468"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="536"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="623"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="295"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="541"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="623"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="646"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="664"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="694"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="774"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ90811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="795" mass="87695" checksum="01A7711F06AD0652" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAU8</accession>
    <name>Q2HAU8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 18">Delta(24(24(1)))-sterol reductase</fullName>
            <ecNumber evidence="15 18">1.3.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">C-24(28) sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Sterol Delta(24(28))-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CHGG_02656</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:18249"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.71"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:18503"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="14 18">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.71" evidence="15 18"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229172.1">
        <property type="nucleotide sequence ID" value="XM_001229171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAU8"/>
    <dbReference type="STRING" id="306901.Q2HAU8"/>
    <dbReference type="GeneID" id="4389724"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02656"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1435">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_280744_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HAU8"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF31">
        <property type="entry name" value="DELTA(24(24(1)))-STEROL REDUCTASE ERG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="8 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13 18" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="9 18" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12 18" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="366"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="944"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="1026"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="1060"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="550"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EAQ90721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1118" mass="125542" checksum="BFBAFDF91293786B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBC0</accession>
    <name>Q2HBC0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">E2 ubiquitin-conjugating enzyme 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ubiquitin-protein ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_02484</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229000.1">
        <property type="nucleotide sequence ID" value="XM_001228999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBC0"/>
    <dbReference type="FunCoup" id="Q2HBC0">
        <property type="interactions" value="702"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HBC0"/>
    <dbReference type="GeneID" id="4388860"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02484"/>
    <dbReference type="eggNOG" id="KOG0426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_10_1_1"/>
    <dbReference type="InParanoid" id="Q2HBC0"/>
    <dbReference type="OMA" id="APDGMFT"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990389">
        <property type="term" value="C:CUE1-UBC7 ubiquitin-conjugating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000837">
        <property type="term" value="C:Doa10p ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000839">
        <property type="term" value="C:Hrd1p ubiquitin ligase ERAD-L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180027">
        <property type="term" value="P:inner nuclear membrane-associated protein degradation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23796">
        <property type="entry name" value="UBCc_UBE2G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000008">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0882">Thioester bond</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="17">
        <location>
            <begin position="5"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="15">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ90549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="166" mass="18753" checksum="E2B4E9C5A06881B4" modified="2006-03-21" version="1">MAQSTAHRRLLQEYRALTNNPPEGITAGPVSEDDLLHWEALIQGPEGTPFEGGVFPAELRFPKDYPLAPPTMKFLGEIWHPNVYPSGLVCISILHPPGDDPNHYEHASERWSPIQSVEKILISVMSMLAEPNDESPANVEAAKMWRERREEYENTVRDGVRRMLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBV3</accession>
    <name>Q2HBV3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_02301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228817.1">
        <property type="nucleotide sequence ID" value="XM_001228816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBV3"/>
    <dbReference type="GeneID" id="4388565"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02301"/>
    <dbReference type="HOGENOM" id="CLU_2222961_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HBV3"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ90366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="106" mass="11528" checksum="E602315706468171" modified="2006-03-21" version="1">MMQGGMGRMYNDLGGYHSAAWGSTAVGNPGLQQLFPRLVCAPRLRRRRETKTAAKRHYGTLGQTNVRILGRADFTFLVQPEPETTAGFGSAVAFVCTLPMTHATAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCR9</accession>
    <name>Q2HCR9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221206.1">
        <property type="nucleotide sequence ID" value="XM_001221205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCR9"/>
    <dbReference type="GeneID" id="4386232"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01985"/>
    <dbReference type="HOGENOM" id="CLU_2385944_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCR9"/>
    <dbReference type="OrthoDB" id="10304188at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208779" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10406" checksum="5B6B4FC6F9CB2E83" modified="2006-03-21" version="1">MQLLTALVLLAATVTAMPTEPQSNEMNFVVRRDTWKRASCAVELPKPKCANACCELAGGCSSLNCADSYCRMFALDQPDYSAEGMFHYATWYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCV6</accession>
    <name>Q2HCV6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isoleucine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_01948</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221169.1">
        <property type="nucleotide sequence ID" value="XM_001221168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCV6"/>
    <dbReference type="FunCoup" id="Q2HCV6">
        <property type="interactions" value="657"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HCV6"/>
    <dbReference type="GeneID" id="4387430"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01948"/>
    <dbReference type="eggNOG" id="KOG0433">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_7_2_1"/>
    <dbReference type="InParanoid" id="Q2HCV6"/>
    <dbReference type="OMA" id="HCWRCKT"/>
    <dbReference type="OrthoDB" id="10264412at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000111">
        <property type="entry name" value="Mitochondrial isoleucyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.830">
        <property type="entry name" value="Ile-tRNA synthetase CP2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050081">
        <property type="entry name" value="Ile-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="13">
        <location>
            <begin position="33"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="14">
        <location>
            <begin position="708"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ93713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="947" mass="105330" checksum="D621AB92533FA224" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCZ8</accession>
    <name>Q2HCZ8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221127.1">
        <property type="nucleotide sequence ID" value="XM_001221126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCZ8"/>
    <dbReference type="GeneID" id="4386244"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01906"/>
    <dbReference type="HOGENOM" id="CLU_3299309_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCZ8"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="40" mass="4435" checksum="D7112A56D60771DC" modified="2006-03-21" version="1">MRSGRQRLARPLSPPSERTTNSSSASCSYFWVLGSVVHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDI0</accession>
    <name>Q2HDI0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pex N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CHGG_01724</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001220944.1"/>
    </dbReference>
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    <dbReference type="STRING" id="306901.Q2HDI0"/>
    <dbReference type="GeneID" id="4386913"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01724"/>
    <dbReference type="eggNOG" id="KOG2879">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024591_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HDI0"/>
    <dbReference type="OMA" id="IMINEME"/>
    <dbReference type="OrthoDB" id="1701437at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF4">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pex N-terminal" evidence="16">
        <location>
            <begin position="149"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="494"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="505"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAQ93489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="597" mass="64483" checksum="B9F1D86201EB79EF" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HE67</accession>
    <name>Q2HE67_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylmalonate-semialdehyde dehydrogenase (CoA acylating)</fullName>
            <ecNumber evidence="2">1.2.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_01487</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
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    <dbReference type="EC" id="1.2.1.27" evidence="2"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220708.1">
        <property type="nucleotide sequence ID" value="XM_001220707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HE67"/>
    <dbReference type="STRING" id="306901.Q2HE67"/>
    <dbReference type="GeneID" id="4387465"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01487"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_10_1"/>
    <dbReference type="InParanoid" id="Q2HE67"/>
    <dbReference type="OMA" id="GGAKNHI"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000002">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase (Acylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000003">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase [acylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="95"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ93252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="582" mass="61960" checksum="C3661268D1BBB5C6" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEL2</accession>
    <name>Q2HEL2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ferric oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_01342</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220563.1">
        <property type="nucleotide sequence ID" value="XM_001220562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEL2"/>
    <dbReference type="FunCoup" id="Q2HEL2">
        <property type="interactions" value="299"/>
    </dbReference>
    <dbReference type="GeneID" id="4386438"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01342"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_2_2_1"/>
    <dbReference type="InParanoid" id="Q2HEL2"/>
    <dbReference type="OMA" id="ILLHRWI"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209177" description="Ferric oxidoreductase domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="10">
        <location>
            <begin position="276"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding 8" evidence="11">
        <location>
            <begin position="434"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ93107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="58150" checksum="EA72E08B09CCD808" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEL3</accession>
    <name>Q2HEL3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_01341</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220562.1">
        <property type="nucleotide sequence ID" value="XM_001220561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEL3"/>
    <dbReference type="GeneID" id="4386437"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01341"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HEL3"/>
    <dbReference type="OMA" id="CFFTMWG"/>
    <dbReference type="OrthoDB" id="5667at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="341"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="45"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ93106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="447" mass="47451" checksum="9C18587F8B225ACF" modified="2006-03-21" version="1">MSTEKPRSSTSMSPDDAVLAPAAPAEAVDTRQPAPFVPPDGGTRAWMTVAGGWLCQFCSFGFINALGSFQFVYEKEILPNESSSNITWILTMQLFLMFFLSQPVGMGVDMFGVRAILIPAAIFSVGGLIALSFATEYWQIFLAQSLCFGLGAAGTFIPGLVAAGQYFKKKRALVMGIVASGSSCGGVVFPIMLARLFDQIGFRQTLRYTALMIGIMLAIANLLVTSPLQPKGLAGRKSLISFATFKKPAYLLFVSGSFLFFWGLFGPFDYLPIFASMNPKTEHIALYTVAILNAASIPGRILPNMYSDKVGSSLRVIALCAFLSAVMVLAIWLPINYHNSLGGLVVFVVLFGFVSGAFVSLMSPALIEVAGGHTHDLGVMLGTFFAIVAVASLTGLPAQGAIADGGDNLVGLIIFCGAVMLAGTALVACAAFVCDREKKRKAAEAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HET8</accession>
    <name>Q2HET8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Vta1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_01266</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220487.1">
        <property type="nucleotide sequence ID" value="XM_001220486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HET8"/>
    <dbReference type="STRING" id="306901.Q2HET8"/>
    <dbReference type="GeneID" id="4386408"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01266"/>
    <dbReference type="eggNOG" id="KOG0917">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030378_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HET8"/>
    <dbReference type="OMA" id="AYWCEYH"/>
    <dbReference type="OrthoDB" id="391137at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="10">
        <location>
            <begin position="76"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="11">
        <location>
            <begin position="418"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="196"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ93031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="48181" checksum="EAA2E817C6F97B2B" modified="2006-03-21" version="1">MQSLASQQRGNGCACSNATWIQRLEIQAGIFPSSAKEHISNAARAGATHDREPPGEKSKLGPRAFEGMAGPNIVGEYWAVNQILAKQLHTTDEDILNYTTNLMDKLEQTKSEHATEDAITDDLAGQAYVEQFAQETLDRAERVVKANRVTQQTATTFDAAATFFHVANIWGPVDQETQQKIKYAKWNAARIVKAIRDGNDPNESNPRHEEAPQPELDPNDPAVQSLGGASPNTGPRPVTVEDVPDSETTKDASGVSLPHSPVLGEPSPISDGGLQLPGVPTDMAEPSPSSYFGPEASITPPPQHPSYSQASPSLPAPPTGWAPSQQSPTTSLPPTAWQQGPVSPTDSGFYQQPSAPTTIPPTFATSPPSTAAVASPPVSPPTNPYYSNTTRPTAPPVAPPVSYAPVQSGGFTTDEAAMVGAQKHAKWAISALNFEDVPTAVRELRDALRLLGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEU2</accession>
    <name>Q2HEU2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PLC-like phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_01262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220483.1">
        <property type="nucleotide sequence ID" value="XM_001220482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEU2"/>
    <dbReference type="GeneID" id="4386404"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01262"/>
    <dbReference type="eggNOG" id="KOG4306">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024751_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HEU2"/>
    <dbReference type="OMA" id="PKQHQCY"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF146">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ93027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="51761" checksum="389462527EEFBCD3" modified="2006-03-21" version="1">MPSKGVHVFTYLAAHGCSIELSVPGQSVSVKELHRFRDVCLEVETSAIESFFDKRGKFTFKVFQNGKQITEQWIDVNALTGNASGGTMESIANTPSIFHGDDIIISYGLYEAGKGHDLLPNRHQCYITVTPNYSNWITNVAPPGSDLENKPFARLVLPSAHDVGMNSMESSEAVLRKVGGAIVAELINDNRILTKLADKLSANAIALIAPNIIFGLAITQKDSLEAMLGIGARYFEFRPAHLHKSVIPTGALPDRLYFQHSAIPGMAYDAFLRGVVSFLRTHPAEIVVVQLRWDGVPDVCAKPSRDEKKQYLDEALRHADGAIVAGNLADMKRMTIGQLRHEKKRLIMLDSVDSLSTYTDEGNATLDGDSILTALPKMLTPGNQKGKAFTNIQCQATASNITKAVVYSILESSVTTSCLLATKGLCDSKTLPWCRDNVLKTCDVNQLVVLMNDWIDGATSDIAVQLSRKRLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFE4</accession>
    <name>Q2HFE4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_01060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220281.1">
        <property type="nucleotide sequence ID" value="XM_001220280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFE4"/>
    <dbReference type="GeneID" id="4386496"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01060"/>
    <dbReference type="HOGENOM" id="CLU_2704593_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HFE4"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ92825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="73" mass="8207" checksum="81BDD2CB0C772F27" modified="2006-03-21" version="1">MGFALAEGEISSLMANYSQDYLGSYRSMPGLPELQPALQDPPLSDWTWLSREAFQVPIHGLISRLIDRDVNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFG5</accession>
    <name>Q2HFG5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_01039</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220260.1">
        <property type="nucleotide sequence ID" value="XM_001220259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFG5"/>
    <dbReference type="FunCoup" id="Q2HFG5">
        <property type="interactions" value="533"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HFG5"/>
    <dbReference type="GeneID" id="4386823"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01039"/>
    <dbReference type="eggNOG" id="KOG0974">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002615_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HFG5"/>
    <dbReference type="OMA" id="DKDLRIM"/>
    <dbReference type="OrthoDB" id="5594999at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051973">
        <property type="entry name" value="tRNA_Anticodon_Mtase-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="153"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="738"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="870"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="740"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ92804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1171" mass="123611" checksum="7D98755B1F756E94" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG17</accession>
    <name>Q2HG17_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_00837</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL54 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220058.1">
        <property type="nucleotide sequence ID" value="XM_001220057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG17"/>
    <dbReference type="STRING" id="306901.Q2HG17"/>
    <dbReference type="GeneID" id="4386630"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00837"/>
    <dbReference type="eggNOG" id="ENOG502S8RU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086132_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HG17"/>
    <dbReference type="OMA" id="YPEWLWR"/>
    <dbReference type="OrthoDB" id="10252718at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013870">
        <property type="entry name" value="Ribosomal_mL54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L54, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08561">
        <property type="entry name" value="Ribosomal_L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="36"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ92602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="221" mass="23799" checksum="98AB0AC55B6FAE24" modified="2006-03-21" version="1">MICRTCLRRAAGFTTRQITPQPFTRAPAAARSFTTTLRTRNATPTAPAAAPATTAAEPSTPDLTPLTPPSAADSEATTGPRSSCPEGTVLSGLNYIKGKSDPVALADEAYPAWLWNCLEVQKKADSTADADTGDEFSKSKKQRRLALKRKRVQEARLLASGDLEALVPKIPLQKQTINLPGAEPGNVGQAVAAVDKREELRRAMRKERRAGIKESNYLKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG96</accession>
    <name>Q2HG96_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FMN hydroxy acid dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_00758</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219979.1">
        <property type="nucleotide sequence ID" value="XM_001219978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG96"/>
    <dbReference type="STRING" id="306901.Q2HG96"/>
    <dbReference type="GeneID" id="4386679"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00758"/>
    <dbReference type="eggNOG" id="KOG0538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020639_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HG96"/>
    <dbReference type="OMA" id="CMLADTD"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03332">
        <property type="entry name" value="LMO_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000132">
        <property type="entry name" value="FMN dependent dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037350">
        <property type="entry name" value="LMO_FMN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF86">
        <property type="entry name" value="DEPENDENT DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G02720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 7" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="34"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="113"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="339"/>
            <end position="343"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="362"/>
            <end position="363"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ92523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="421" mass="44885" checksum="1AE9CE3852E4AB20" modified="2006-03-21" version="1">MSEPQDKDGSDGEEKVPYGQYQFDLYAQAMIAGQKPIVTTDPNKLEQAAREAMAPEAFNYVFGGAGEQATMHANRLAFRQWKLIPRMLRPTMPRDLSVELFGKKYDTPLLMAPIGVQGAYHPHGEEGVATACASLHVPYIYSTAATTPLEAVASAAPAVPRWFQLYWPLSDALTASLLSRARAAGCAALVVTLDTFTMSWRPLDLDAGYLPFARGQGNALGFSDPAFRRMFAEGNEGDGDVDGKENVVAASRAWLAEVFSGHAHRWEDLAVLRRLWGDGPIVLKGVLSVGDAEMAVRAGVDGIVVSNHGGRQLDGAVPALEMLPEIVDAVGDRLTVLYDSGVRTGADVLKALALGAKAVLVGRPVIYGLGIAGSEGARHVLAGLLADVDQSMGLAGVQNVSELNRSILRKINYGGDVKSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGX3</accession>
    <name>Q2HGX3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_00531</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219752.1">
        <property type="nucleotide sequence ID" value="XM_001219751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGX3"/>
    <dbReference type="FunCoup" id="Q2HGX3">
        <property type="interactions" value="401"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HGX3"/>
    <dbReference type="GeneID" id="4387884"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00531"/>
    <dbReference type="eggNOG" id="KOG0581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="InParanoid" id="Q2HGX3"/>
    <dbReference type="OMA" id="MIAKCLM"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071507">
        <property type="term" value="P:pheromone response MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034307">
        <property type="term" value="P:regulation of ascospore formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06620">
        <property type="entry name" value="PKc_Byr1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000253">
        <property type="entry name" value="MAP kinase kinase Ste7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049613">
        <property type="entry name" value="Byr1-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="64"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="337"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="356"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ92296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="397" mass="44220" checksum="01A6214165EE73E5" modified="2006-03-21" version="1">MADAFAPRSMKRKNVKGLALKAPAPKPPPTAENASRPANGKGDDNAAQLEIGIEFNLDLKPDDLEIIKDLGAGNGGTIIHVEAKKEMRKRIVRELQIMHGCHSDYIVTFYGAFLNENNDVIMCMEYMDVGSLDRISRVFGPVRVDVLGKIAEATLGGLTYLYSKHHIMHRDIKPSNILVNSRGSIKLCDFGVSGELINSVADTFVGTSTYMAPERIQGERYTVKSDVWSFGLSIMELAIGKFPFAASEQLSDAESAPAGILDLLQQIVHEPAPQLPKSDAFPQILEDMIQRCLYKEPERRPTPQDLFDRDLFVQAAKRTPVDLREWACGLMDRDNRKSHLAPQLSPATQDLLRASDSPTFAQQTPTSSYRNDPRQAADHTNLAAQVDRLYIREWDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGZ0</accession>
    <name>Q2HGZ0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219735.1">
        <property type="nucleotide sequence ID" value="XM_001219734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGZ0"/>
    <dbReference type="PeroxiBase" id="4648">
        <property type="entry name" value="CgCMDn"/>
    </dbReference>
    <dbReference type="GeneID" id="4388041"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00514"/>
    <dbReference type="eggNOG" id="ENOG502RZ3K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082760_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HGZ0"/>
    <dbReference type="OMA" id="RVAVCNK"/>
    <dbReference type="OrthoDB" id="9998495at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846:SF11">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxymuconolactone decarboxylase-like" evidence="1">
        <location>
            <begin position="44"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="203" mass="22386" checksum="EB6E111AAFE36903" modified="2006-03-21" version="1">MRIPYVPNPPEPSSAEEAAIVSRIQARRAPRPLQPLDLALLHAPAVADGWNSFLGAVRTRTGLAADLREIAISRVAVVNRAWYEWAHHAPLAEQGGVSKLGMEAVRREEELRLEDPVPEGLTAQQWAVVCYAEEMTRNVQVRDETFAKLREMFGEKEIVEITATVACYNCVSRFLVALDDSALEIQIGLMASSTQDRPAPNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHR4</accession>
    <name>Q2HHR4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pisatin demethylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_00240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219461.1">
        <property type="nucleotide sequence ID" value="XM_001219460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHR4"/>
    <dbReference type="STRING" id="306901.Q2HHR4"/>
    <dbReference type="GeneID" id="4386596"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00240"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="InParanoid" id="Q2HHR4"/>
    <dbReference type="OMA" id="EWIMARV"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ92005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="56757" checksum="C065E2A14BEAE315" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHT7</accession>
    <name>Q2HHT7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CHGG_00217</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219438.1">
        <property type="nucleotide sequence ID" value="XM_001219437.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2HHT7">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="GeneID" id="4387762"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5017987at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Integrase_cat-core"/>
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    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
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        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
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        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
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        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="18" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="15" id="KW-0695">RNA-directed DNA polymerase</keyword>
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    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="17" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="23">
        <location>
            <begin position="527"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="280"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="805"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1292"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="810"/>
            <end position="819"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ91982.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1389" mass="157667" checksum="4F36B62FF35284AD" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI29</accession>
    <name>Q2HI29_CHAGB</name>
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        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001219345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HI29"/>
    <dbReference type="GeneID" id="4387813"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00125"/>
    <dbReference type="eggNOG" id="ENOG502SJKQ">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014722_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HI29"/>
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    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF1996"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF5">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209198" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="31"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="354" mass="38658" checksum="512174DDAE03358A" modified="2006-03-21" version="1">MKWLSLSLALAGSSQAALRFGCSTVSIQRLDPLVEPGKLPSSHVHQIVGGNAFNATMEGDIAEQADCTTCTFSENFSNYWTAVMFFKHSNGSYKRVPIMQNTALPNGINGGMTIYYTQQDFNSNGNQKITAFKPGFRMTVGSPTYSAEPGSKGNPGLRFVCLQNKGTRFPELPSFPTQPCVGGIMTVHHFPSCWDGKNLDSPDHQSHMYNTVREAFAPAGACPSSHPVRMPQLAFETLWDTTQFNGMWPADGSNPFVLSYGDGVGYGTHADYVFGWKGDALQRAMDSSCMFNACENGRPLKSQNVQAMNKCAVKSQVNEDLDGWLDHLPGQGMDAPQAHGRIAGRITIHTPRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI85</accession>
    <name>Q2HI85_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219290.1">
        <property type="nucleotide sequence ID" value="XM_001219289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HI85"/>
    <dbReference type="GeneID" id="4386584"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00069"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_7_1_1"/>
    <dbReference type="InParanoid" id="Q2HI85"/>
    <dbReference type="OMA" id="CEKIGRT"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="38143" checksum="F9ABE3FE7D54DD27" modified="2006-03-21" version="1">MPSPTPSPPTSPDHVEVDDTTAPETGGGALDDADSAYGDDGSSSASTSLRSSILRYEWKHGRRYHAYQAGKYSFPNDEREQERLDMVHHVYFRTLHDRLFLAPVDPDAGLRVLDVGTGTGMWAIHLGDDYPGAAEIVGNDLSPIQPSWCPPNVRFIVDDVELDWAEPLPYDLIHCRYMAGAIKDWPRLIKQMYDNLKPGGWLEFQESANTLYSQDGSLTRKDPLSKLMDGLMEACEKIGRTMDPAPSMEQWVRDAGFVNVKVEVFKMPVGAWPKDPRLKEIGTLLGVNFTEGVEAFTAALFADVLGWSKEEITVLNAGVRDSIKRGEAHALFDFMVITGQRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM78</accession>
    <name>Q2GM78_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226193.1">
        <property type="nucleotide sequence ID" value="XM_001226192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GM78"/>
    <dbReference type="FunCoup" id="Q2GM78">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GM78"/>
    <dbReference type="GeneID" id="4397336"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10926"/>
    <dbReference type="eggNOG" id="KOG1674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013692_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GM78"/>
    <dbReference type="OMA" id="PMRGEGM"/>
    <dbReference type="OrthoDB" id="1060854at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF94">
        <property type="entry name" value="PHO85 CYCLIN-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="57385" checksum="C4DD1EDDC33884C3" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMX9</accession>
    <name>Q2GMX9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="8">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_10675</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228602.1">
        <property type="nucleotide sequence ID" value="XM_001228601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMX9"/>
    <dbReference type="FunCoup" id="Q2GMX9">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GMX9"/>
    <dbReference type="GeneID" id="4396325"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10675"/>
    <dbReference type="eggNOG" id="KOG2431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GMX9"/>
    <dbReference type="OMA" id="FHENQNA"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF89">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="513"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="337"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ84271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="527" mass="59436" checksum="CB68FA6B2A0C20D7" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN94</accession>
    <name>Q2GN94_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228487.1">
        <property type="nucleotide sequence ID" value="XM_001228486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN94"/>
    <dbReference type="GeneID" id="4395939"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10560"/>
    <dbReference type="eggNOG" id="ENOG502SY3V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029216_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GN94"/>
    <dbReference type="OMA" id="TWYCDDV"/>
    <dbReference type="OrthoDB" id="5186097at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208823" description="AA1-like domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="52020" checksum="439900A69B8C9F18" modified="2006-03-21" version="1">MAMRLLLAATSVAVLVSARASSDGSACTAKSFAIPSWFVQDVKHAEGVISFNVWNRATNYTADLACETTKTGLNACSVQGTPSSNDTLEASVEISGDPTTFHLKQSWTCSDREKSLKFTAAGNNSAAADYTSPLLIKGSLTSPVSITPVYPDGPKGHDSAGCSSRSESPTWTLSSIHYTDEPASGEGTVAFKNFNVLVTNPANGYQASCMPGGSFGDQPDLAHLMCAGYEFQSSSVGQYPIVTQASFDPETSTFTLNQTWFCDDVDAAKPLQITATGSSTLPLTCTTTPGTRNQTNTYCSTASSVTLTGQSGLTTTLRPYALEDPAPSWASTPPRGDGCTLTSIFAPRWQFSAFRVDGGAVSFEIILMAGDRGFQYPIPVYQGEAVAGEGGEGWYECEVGADGGNGLPLWPYQCRFRYEEGEEGKGGMLLLDADWECRDLDRVHPVKFSGVTNTAVNTTLECETVDGVSQCMTTDPGYTWVAPISDVTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNA8</accession>
    <name>Q2GNA8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CHGG_10546</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228473.1">
        <property type="nucleotide sequence ID" value="XM_001228472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNA8"/>
    <dbReference type="FunCoup" id="Q2GNA8">
        <property type="interactions" value="835"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GNA8"/>
    <dbReference type="GeneID" id="4395959"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10546"/>
    <dbReference type="eggNOG" id="KOG0749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_12_0_1"/>
    <dbReference type="InParanoid" id="Q2GNA8"/>
    <dbReference type="OMA" id="CWATIYK"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000001">
        <property type="entry name" value="ADP,ATP carrier protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="13"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="118"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="222"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAQ84142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="311" mass="33842" checksum="D367FA5E6F13B32A" modified="2006-03-21" version="1">MSKKEDIKILGMPSFVVDFLMGGVSAAVSKTAAAPIERIKLLVQNQDEMIKAGRLDRRYNGIVDCFRRTTADEGLMALWRGNTANVIRYFPTQALNFAFRDKFKAMFGYKKERDGYAKWMAGNLASGGAAGATSLLFVYSLDYARTRLANDAKSAKGGGARQFNGLIDVYRKTMATDGIAGLYRGFGPSVAGIVVYRGLYFGMYDSIKPVVLVGSLANNFFASFMLGWCVTTGAGIASYPLDTVRRRMMMTSGEAVKYKSSFDAFQQIVAKEGVKSLFKGAGANILRGVAGAGVLSIYDQLQVLMFGKAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNR5</accession>
    <name>Q2GNR5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_10389</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228316.1">
        <property type="nucleotide sequence ID" value="XM_001228315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNR5"/>
    <dbReference type="STRING" id="306901.Q2GNR5"/>
    <dbReference type="GeneID" id="4397039"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10389"/>
    <dbReference type="eggNOG" id="ENOG502QUDZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041333_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNR5"/>
    <dbReference type="OMA" id="TRHDPEY"/>
    <dbReference type="OrthoDB" id="359154at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22682">
        <property type="entry name" value="Ribosomal_uL24m-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ83985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="59225" checksum="B4544FFBDC793626" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNS5</accession>
    <name>Q2GNS5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Armadillo repeat-containing protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_10379</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228306.1">
        <property type="nucleotide sequence ID" value="XM_001228305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNS5"/>
    <dbReference type="STRING" id="306901.Q2GNS5"/>
    <dbReference type="GeneID" id="4396617"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10379"/>
    <dbReference type="eggNOG" id="KOG1293">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002741_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GNS5"/>
    <dbReference type="OMA" id="TIGHDQR"/>
    <dbReference type="OrthoDB" id="5559898at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038739">
        <property type="entry name" value="ARMC8/Vid28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651:SF7">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="484"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="563"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="717"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="572"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ83975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="989" mass="106482" checksum="9FB535654A7C4B9A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2023-02-22" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNT4</accession>
    <name>VEA_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Developmental and secondary metabolism regulator veA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Velvet complex subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">veA</name>
        <name type="ORF">CHGG_10370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2022" name="Synth. Syst. Biotechnol." volume="7" first="1084" last="1094">
            <title>CgVeA, a light signaling responsive regulator, is involved in regulation of chaetoglobosin A biosynthesis and conidia development in Chaetomium globosum.</title>
            <authorList>
                <person name="Wang Z."/>
                <person name="Zhao S."/>
                <person name="Zhang K."/>
                <person name="Lin C."/>
                <person name="Ru X."/>
                <person name="Yang Q."/>
            </authorList>
            <dbReference type="PubMed" id="35949485"/>
            <dbReference type="DOI" id="10.1016/j.synbio.2022.07.002"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 4">Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination (By similarity). The velvet complex acts as a global regulator for secondary metabolite gene expression (By similarity). Positively regulates chaetoglobosin A biosynthesis by controlling the expression of core genes of the chaetoglobosin A biosynthetic gene cluster and other relevant regulators in a light-dependent manner (PubMed:35949485). VeA directly regulates transcription factors brlA, laeA, and the chaetoglobosin A cluster-specific transcription regulator cheR (PubMed:35949485). Also directly regulates the expression of one of the chaetoglobosin A cluster cytochrome P450 monooxygenases (cheE or cheG), but only indirectly regulates the expression of the PKS-NRPS hybrid cheA (PubMed:35949485). Moreover, VeA has a significant effect on the asexual spores production, irrespective of light or dark condition (PubMed:35949485).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the heterotrimeric velvet complex composed of laeA, veA and velB; VeA acting as a bridging protein between laeA and velB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Enriched in the nucleus in the dark.</text>
    </comment>
    <comment type="induction">
        <text evidence="4">Expression under light condition is higher than that under dark condition (PubMed:35949485). Expressed almost constitutively at an increased level throughout the asexual and sexual developmental processes (PubMed:35949485).</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The C-terminal PEST domain is a region rich in proline, glutamic acid, serine and threonine residues that is required for the light-dependent regulation of development and secondary metabolism.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Decreases the production of chaetoglobosin A.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the velvet family. VeA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228297.1">
        <property type="nucleotide sequence ID" value="XM_001228296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNT4"/>
    <dbReference type="SMR" id="Q2GNT4"/>
    <dbReference type="STRING" id="306901.Q2GNT4"/>
    <dbReference type="GeneID" id="4396351"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10370"/>
    <dbReference type="eggNOG" id="ENOG502QVY9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022491_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GNT4"/>
    <dbReference type="OMA" id="IFRPSPM"/>
    <dbReference type="OrthoDB" id="5384689at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034250">
        <property type="term" value="P:positive regulation of amide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051176">
        <property type="term" value="P:positive regulation of sulfur metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043455">
        <property type="term" value="P:regulation of secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.3960:FF:000001">
        <property type="entry name" value="Sexual development activator VeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF14">
        <property type="entry name" value="DEVELOPMENTAL AND SECONDARY METABOLISM REGULATOR VEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0749">Sporulation</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000457171" description="Developmental and secondary metabolism regulator veA">
        <location>
            <begin position="1"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Velvet" evidence="2">
        <location>
            <begin position="35"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="250"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="PEST" evidence="1">
        <location>
            <begin position="455"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Nuclear localization signal" evidence="1">
        <location>
            <begin position="49"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="411"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="508"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="546"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="C8VTV4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="35949485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="35949485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ83966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="560" mass="61552" checksum="EB9001DB12D1E3DC" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNX6</accession>
    <name>Q2GNX6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Genetic interactor of prohibitins 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228255.1">
        <property type="nucleotide sequence ID" value="XM_001228254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNX6"/>
    <dbReference type="STRING" id="306901.Q2GNX6"/>
    <dbReference type="GeneID" id="4396008"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10328"/>
    <dbReference type="eggNOG" id="ENOG502S067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015286_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNX6"/>
    <dbReference type="OMA" id="GWLNNKP"/>
    <dbReference type="OrthoDB" id="1696305at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050896">
        <property type="entry name" value="Mito_lipid_metab_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434:SF1">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="68570" checksum="5D200664867EE8F0" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GP03</accession>
    <name>Q2GP03_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_10301</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228228.1">
        <property type="nucleotide sequence ID" value="XM_001228227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GP03"/>
    <dbReference type="FunCoup" id="Q2GP03">
        <property type="interactions" value="1158"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GP03"/>
    <dbReference type="GeneID" id="4396313"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10301"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="InParanoid" id="Q2GP03"/>
    <dbReference type="OMA" id="QTTVSWM"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000044">
        <property type="entry name" value="Hexose transporter Hxt3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF92">
        <property type="entry name" value="LOW AFFINITY GLUCOSE TRANSPORTER MSTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="39"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="507"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ83897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="539" mass="58718" checksum="8AA225C9BFF72E36" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPR3</accession>
    <name>Q2GPR3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227968.1">
        <property type="nucleotide sequence ID" value="XM_001227967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPR3"/>
    <dbReference type="STRING" id="306901.Q2GPR3"/>
    <dbReference type="GeneID" id="4396017"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10041"/>
    <dbReference type="HOGENOM" id="CLU_2941527_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPR3"/>
    <dbReference type="OrthoDB" id="4584184at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ83637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="60" mass="6703" checksum="1BF4EF0AD6D503A7" modified="2006-03-21" version="1">MPVLVDFGSCREIGTKLGASWGTVGWIDGDILEYAVSEERHDLSALGKIRVWLDSPHFDR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2026-01-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPS8</accession>
    <name>CCDK_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription fator ccdK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Cochliodone A biosynthesis cluster protein K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ccdK</name>
        <name type="ORF">CHGG_10026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2025" name="J. Am. Chem. Soc." volume="147" first="11555" last="11563">
            <title>Mechanism of Unexpected In-Trans Post-PKS Polyketide Reduction in Cochliodone Biosynthesis.</title>
            <authorList>
                <person name="Sarmales-Murga C."/>
                <person name="Sato M."/>
                <person name="Kosaka M."/>
                <person name="Akaoka F."/>
                <person name="Watanabe K."/>
            </authorList>
            <dbReference type="PubMed" id="40111931"/>
            <dbReference type="DOI" id="10.1021/jacs.5c03717"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Transcription fator; part of the gene cluster that mediates the biosynthesis of cochliodone A, a dimerized azaphilone (PubMed:40111931). Regulates the expression of the cochliodone A cluster genes and subsequent production of cochliodone A (PubMed:40111931).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="1">Leads to a complete loss of production of cochliodone A.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227953.1">
        <property type="nucleotide sequence ID" value="XM_001227952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPS8"/>
    <dbReference type="GeneID" id="4396047"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10026"/>
    <dbReference type="eggNOG" id="ENOG502T5Y8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_662538_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPS8"/>
    <dbReference type="OrthoDB" id="4222821at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000462672" description="Transcription fator ccdK">
        <location>
            <begin position="1"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="40111931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="40111931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="410" mass="44357" checksum="2C57512A8B4E8172" modified="2006-03-21" version="1">MNNHWNPAMDVTVVQPYHASERPDSRCSVTAPSDPFEDDGVIDSLLHADDALAGGLDPSFRDQVAAWSAALTGDGIKHWDGLAMADHSHHAIGNSADEQPLAVGTAEFRPAHVTTSRHPPTTPPIRSQPQLTTSPACIHASALREQNEYQTVKGSLAALVRRAAELCDNMYDLRIRYHDGHSELDPPGHFPIHMSGEVLKAADAFLRLLRCFFSDEHRGCSTPTLVPDPPPSTGPYSSSLVPGQTRRVAHVADRPAALTLIASYRRLLDLYLLYYQGVYEYVRDTDSARRRNQPIWKDLSVGGAPLRDFGDLHIKLVMQAAARVLEDIEGALGLAEGCRVSRRSVDEAGSGGDGILGTVVTSRFVEQCIAEGATGGSEQGPGITARIRDMAAGLAALLDAPDIERSSYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GR87</accession>
    <name>Q2GR87_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_09517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227444.1">
        <property type="nucleotide sequence ID" value="XM_001227443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GR87"/>
    <dbReference type="STRING" id="306901.Q2GR87"/>
    <dbReference type="GeneID" id="4395618"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09517"/>
    <dbReference type="eggNOG" id="ENOG502RZSK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008976_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GR87"/>
    <dbReference type="OMA" id="PVAQMFK"/>
    <dbReference type="OrthoDB" id="5238236at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="2">
        <location>
            <begin position="299"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ85503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1101" mass="123795" checksum="A02909C638ECF30F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRR0</accession>
    <name>Q2GRR0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450 monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_09344</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227271.1">
        <property type="nucleotide sequence ID" value="XM_001227270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRR0"/>
    <dbReference type="STRING" id="306901.Q2GRR0"/>
    <dbReference type="GeneID" id="4395108"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09344"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="InParanoid" id="Q2GRR0"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ85330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="597" mass="67342" checksum="F8348EFACFC8BB46" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRW4</accession>
    <name>Q2GRW4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA N(6)-methyladenine demethylase</fullName>
            <ecNumber evidence="2">1.14.11.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_09290</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an N(6)-methyladenosine in mRNA + 2-oxoglutarate + O2 = an adenosine in mRNA + formaldehyde + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:49520"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12417"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="1.14.11.53"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:49521"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkB family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.53" evidence="2"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227217.1">
        <property type="nucleotide sequence ID" value="XM_001227216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRW4"/>
    <dbReference type="STRING" id="306901.Q2GRW4"/>
    <dbReference type="GeneID" id="4395224"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09290"/>
    <dbReference type="eggNOG" id="KOG2731">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029471_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRW4"/>
    <dbReference type="OMA" id="APVICHA"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990931">
        <property type="term" value="F:mRNA N6-methyladenosine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.590:FF:000014">
        <property type="entry name" value="Oxidoreductase, 2OG-Fe(II) oxygenase family family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004574">
        <property type="entry name" value="Alkb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557:SF2">
        <property type="entry name" value="NUCLEIC ACID DIOXYGENASE ALKBH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="10">
        <location>
            <begin position="183"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604574-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ85276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="296" mass="32922" checksum="05DD567B0A7A5F4C" modified="2006-03-21" version="1">MTVDIKHLDAHEQPSDELRAKWKVFAKTEPKDLRSEDIDDLQNPESAAEFCLAGTLPVDTLNRSFRQICPDDDSEFQATKDAPIYYHPLLPAPPFPTTTTTSSSFFTYPPTSPPTFTPKDPTIHKPLTIKQVLDRRLHWVTLGGQYDWTNRVYPDEDGSPSSSPPAFPRDVAAFLETLFPDTRAQAAIVNLYTPGDTMMMHRDVSEESSRGLVSVSLGCEGLFMIAPNGGVAEEEGGGGEEEGGKREKEFLLLRLRSGDAIYMTEESRFAWHGVPKVLKGTCPEYLEEWARGGGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GS01</accession>
    <name>Q2GS01_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3HC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_09253</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227180.1">
        <property type="nucleotide sequence ID" value="XM_001227179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GS01"/>
    <dbReference type="STRING" id="306901.Q2GS01"/>
    <dbReference type="GeneID" id="4395590"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09253"/>
    <dbReference type="eggNOG" id="KOG4765">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031412_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GS01"/>
    <dbReference type="OrthoDB" id="2592092at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012935">
        <property type="entry name" value="NuBaID_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835">
        <property type="entry name" value="NUCLEAR-INTERACTING PARTNER OF ALK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835:SF6">
        <property type="entry name" value="ZINC FINGER C3HC-TYPE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07967">
        <property type="entry name" value="zf-C3HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C3HC-type" evidence="4">
        <location>
            <begin position="131"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="266"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ85239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="396" mass="42493" checksum="DD6A5AD2A0AFAD12" modified="2006-03-21" version="1">MNSNVKRKFNALLQGIGSRPPAEYGTDRDSLADPASSPISQHSSPQRPRTMAGDSSADLLKKRRTGGPTTTPSKYTTLQTTPMRSSPASIRSVPPSTTTVSNVTLRKWTPGAGSPAHDGRDGLPPPPKYCPGDRDQLLRRLTTFQELTDWTPKPDRVSEVEWAKRGWACQGKERVKCTLCGRELVVKVNRKEVDGKEVAVLIASEVAESVVDAYAALIVESHAEDCLWRKRGCDGEEREEVPLPAAWEVLVVGLRNEAFIRERVAGGGGSRKKKARGVVPGQSQSHGHGRSKSSVPAPGSGSGGGGDGAAVPKTPERPVTVDGRPRGLVGGEGEDGEEEGREGEVDDEEARNRKDRDMMSRLRRVKSLFNTKAGGKLRKLGSSRPGTSHSNVGGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSR1</accession>
    <name>Q2GSR1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226920.1">
        <property type="nucleotide sequence ID" value="XM_001226919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSR1"/>
    <dbReference type="FunCoup" id="Q2GSR1">
        <property type="interactions" value="697"/>
    </dbReference>
    <dbReference type="GeneID" id="4395260"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08993"/>
    <dbReference type="eggNOG" id="KOG2137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008724_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GSR1"/>
    <dbReference type="OMA" id="MAHKCIP"/>
    <dbReference type="OrthoDB" id="79687at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF6">
        <property type="entry name" value="SCY1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="872"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="712"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="753"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="875"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="910" mass="98269" checksum="19E2EBBE91933BC6" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTF3</accession>
    <name>Q2GTF3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_08751</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226678.1">
        <property type="nucleotide sequence ID" value="XM_001226677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTF3"/>
    <dbReference type="GeneID" id="4395675"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08751"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="InParanoid" id="Q2GTF3"/>
    <dbReference type="OMA" id="AISMIYV"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000313">
        <property type="entry name" value="MFS quinate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF8">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="31"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ84737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="562" mass="61625" checksum="EF809AE61D633F04" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTG3</accession>
    <name>Q2GTG3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta-mannosidase B</fullName>
            <ecNumber evidence="3">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mannanase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_08741</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="3"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226668.1">
        <property type="nucleotide sequence ID" value="XM_001226667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTG3"/>
    <dbReference type="STRING" id="306901.Q2GTG3"/>
    <dbReference type="GeneID" id="4395074"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08741"/>
    <dbReference type="eggNOG" id="KOG2230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005015_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GTG3"/>
    <dbReference type="OMA" id="QFACASY"/>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000118">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000050">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="13">
        <location>
            <begin position="13"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="11">
        <location>
            <begin position="198"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="12">
        <location>
            <begin position="708"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ84727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="836" mass="95238" checksum="5A74874C9D22849F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUB4</accession>
    <name>Q2GUB4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_08440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226367.1">
        <property type="nucleotide sequence ID" value="XM_001226366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUB4"/>
    <dbReference type="STRING" id="306901.Q2GUB4"/>
    <dbReference type="GeneID" id="4395886"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08440"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_1_2_1"/>
    <dbReference type="InParanoid" id="Q2GUB4"/>
    <dbReference type="OMA" id="STNCWLQ"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF54">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="54"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ84426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="485" mass="51769" checksum="4637B2F199E40984" modified="2006-03-21" version="1">MTQATKRCPSSGHSDPATSAAEACLAAQQALGPDLVIIAPVDQSFIDVNWSETCWAAPSCVVRPTSAQLLATVLRIIVQFQVLFAIRSGGHSPNPGWASIGEPGVLLDLSRLDTITVSDDASVVSVGPGQRWGGVVEALDSHNVTAVAGRLTSLGVGGLLLGGGFSFFSGEYGLAADNVRSVELVLGNGTVVEASAQENPDLFWALKGGGPNYGIVTRFDLFTIPIQKVYAEVVFYAPADTPTFLRALADWQLKAAASDPRATVIAVSTLGGTTAGFIYSQPVTARPDIFAAFSDIPVLAAALPPTNLSPLELMEVSAGQVGWTANRHDYRGVSTQIDGDLYVDMYNFWAERAADVYSKTGANQTFVIQPITVNLAKQSADKGGNALGMAPSSSMSWWTTLIDWENAADDDVVRSVSIATTEEWKKRSTVELLYMNDCSRDQDPLRSYGAENVAKLCEVSHKYDPGQVFQKLQHDGFLLRKLGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUG3</accession>
    <name>Q2GUG3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226318.1">
        <property type="nucleotide sequence ID" value="XM_001226317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUG3"/>
    <dbReference type="GeneID" id="4394685"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08391"/>
    <dbReference type="HOGENOM" id="CLU_527847_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUG3"/>
    <dbReference type="OMA" id="PVEFAHA"/>
    <dbReference type="OrthoDB" id="4849731at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208468" evidence="2">
        <location>
            <begin position="22"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="516" mass="54548" checksum="CCF7E10D54AD4B04" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUP7</accession>
    <name>Q2GUP7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">26S proteasome regulatory subunit 8 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_08307</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ87054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225963.1">
        <property type="nucleotide sequence ID" value="XM_001225962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUP7"/>
    <dbReference type="FunCoup" id="Q2GUP7">
        <property type="interactions" value="939"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GUP7"/>
    <dbReference type="GeneID" id="4394151"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08307"/>
    <dbReference type="eggNOG" id="KOG0728">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_2_1_1"/>
    <dbReference type="InParanoid" id="Q2GUP7"/>
    <dbReference type="OMA" id="HSYFTQK"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="45"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ87054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="269" mass="29989" checksum="5582EFF1C8CF8673" modified="2006-03-21" version="1">MMVEKVPDSTYDMIGGLDQQIKEIKEVIELGLKHPELFESLGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCKFIRVSGSELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRVEGSSGGDSEVQRTMLELLNQLDGFEPTKNIKVIMATNRLDILDPALLRPGRIDRKIEFPPPSVEARADILRIHSRKMNLTRGINLTKIAEKMNGCSGAELKGVCTEAGMYALRERRVHVTQEDFELATAKILNKHDDKEVSLAKLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUU3</accession>
    <name>Q2GUU3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ87008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225917.1">
        <property type="nucleotide sequence ID" value="XM_001225916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUU3"/>
    <dbReference type="FunCoup" id="Q2GUU3">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="ESTHER" id="chagb-q2guu3">
        <property type="family name" value="Dienelactone_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="4393339"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08261"/>
    <dbReference type="eggNOG" id="ENOG502QQFN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GUU3"/>
    <dbReference type="OMA" id="NIRIFMI"/>
    <dbReference type="OrthoDB" id="58297at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562:SF2">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="63"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="243" mass="26385" checksum="ADC0C09FECBE5D9C" modified="2006-03-21" version="1">MLIKESFADVKTLADGKEGSMRIFLFHPTIAGYPNARFPGVVLFSEIYQGEMHSLRPATSNSLCVVDSTRSVDYLLSLPTCTGRIGATGMCLGGHLALRASLDPRITASVCYFPTDIHTRTLGPYTAANSSATAPSADSQHTLDQLGRIRGEVSLIFGVKDTHVPDAGRDLIRLKMREAGVTTSFHEFAWAQHAFIRDELSKGRYDPAVSKACFEVLLEVFGRVLKTELGEPEGGVPAVEHVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV35</accession>
    <name>Q2GV35_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_08169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225825.1">
        <property type="nucleotide sequence ID" value="XM_001225824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV35"/>
    <dbReference type="GeneID" id="4393298"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08169"/>
    <dbReference type="HOGENOM" id="CLU_2512426_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GV35"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ86916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="85" mass="9759" checksum="4830B77B83F9154B" modified="2006-03-21" version="1">MAEIFFLTLPLLLHPGPWCWRRVLSLVEFHQSDSISRQGDERLRRIDRGMGRLLVPQRSFGRGFWVPACASASALHRTWTLVKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV86</accession>
    <name>Q2GV86_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_08118</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225774.1">
        <property type="nucleotide sequence ID" value="XM_001225773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV86"/>
    <dbReference type="FunCoup" id="Q2GV86">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="GeneID" id="4394302"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08118"/>
    <dbReference type="eggNOG" id="ENOG502QRFY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096561_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GV86"/>
    <dbReference type="OMA" id="ADWMTKH"/>
    <dbReference type="OrthoDB" id="289247at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040250">
        <property type="entry name" value="Nucleobindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237">
        <property type="entry name" value="NUCLEOBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237:SF20">
        <property type="entry name" value="NUCLEOBINDIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="71"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ86865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="185" mass="21552" checksum="386416031DDC0208" modified="2006-03-21" version="1">MALRPADEHDPLADTRLPPHPPAEEHHADGFDAASFFALHDFDADGNWEGEEILRTYGLMDESNKDVPEQRRVQIVQEILGLIDTNRDGRISRDEFVRFIETDGKTLPDMGTGPGHHGDDEYEYEIHHWEKYHDENTKLEDLTHPEDIEHFKKHEQMEAEQERLEKMSKQSIIESNIPSKFRRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVL4</accession>
    <name>Q2GVL4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit GON7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_07990</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GON7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225646.1">
        <property type="nucleotide sequence ID" value="XM_001225645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVL4"/>
    <dbReference type="GeneID" id="4393315"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07990"/>
    <dbReference type="eggNOG" id="ENOG502T1MI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146833_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GVL4"/>
    <dbReference type="OMA" id="PFKVAHT"/>
    <dbReference type="OrthoDB" id="2288868at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014849">
        <property type="entry name" value="EKC/KEOPS_Gon7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08738">
        <property type="entry name" value="Gon7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="69"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ86737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="106" mass="11801" checksum="90389FF35C38CFB2" modified="2006-03-21" version="1">MTAQQQQQQPTLSATYTSTTNAPFTVSLTLPCAADSTTLEHKTKYLSELRQSVISAQGQINRELTARMEEDKAREASTAKANGTKVVDDEKEEENYGEEVQEEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVQ6</accession>
    <name>Q2GVQ6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PRKR-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225604.1">
        <property type="nucleotide sequence ID" value="XM_001225603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVQ6"/>
    <dbReference type="STRING" id="306901.Q2GVQ6"/>
    <dbReference type="GeneID" id="4394579"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07948"/>
    <dbReference type="eggNOG" id="KOG4055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079129_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GVQ6"/>
    <dbReference type="OMA" id="RIEPRTN"/>
    <dbReference type="OrthoDB" id="10067079at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009548">
        <property type="entry name" value="Prkrip1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507:SF0">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06658">
        <property type="entry name" value="DUF1168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="23609" checksum="CC7CF57582ED4300" modified="2006-03-21" version="1">MTNLPPAKRRRALSPHASQATHLAALFSNPTQEIRLPPPTSSTTPANSRKPLPPPPEIVTNVQGSSAGAGSGEFHVYKAARRREYERLRQMDEDLARERAGSEFERRRAEREREDEERTRRNRERRERKKKKGKGGKGKKGGEGGGDGDGDGKGDSPKGEGGGVGVAAVKGGEGEVGGDTGNKGGKDGDKENGEGGTGADADTGKKQEAPVVADGPGAVIHDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GW63</accession>
    <name>Q2GW63_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Myosin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_07791</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225447.1">
        <property type="nucleotide sequence ID" value="XM_001225446.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2GW63">
        <property type="interactions" value="533"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GW63"/>
    <dbReference type="GeneID" id="4394333"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07791"/>
    <dbReference type="eggNOG" id="KOG0160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000192_3_1_1"/>
    <dbReference type="InParanoid" id="Q2GW63"/>
    <dbReference type="OMA" id="EIMFDDR"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15480">
        <property type="entry name" value="fMyo2p_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046943">
        <property type="entry name" value="Fungal_Myo2/2A_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50084">
        <property type="entry name" value="Myosin S1 fragment, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="12">
        <location>
            <begin position="6"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="11">
        <location>
            <begin position="74"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="10">
        <location>
            <begin position="1149"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="8">
        <location>
            <begin position="577"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="963"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1481"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="967"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1484"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1501"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="168"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ86538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1530" mass="172707" checksum="538EB95EE180B74D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GW93</accession>
    <name>Q2GW93_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_07761</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225417.1">
        <property type="nucleotide sequence ID" value="XM_001225416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GW93"/>
    <dbReference type="STRING" id="306901.Q2GW93"/>
    <dbReference type="GeneID" id="4394200"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07761"/>
    <dbReference type="eggNOG" id="KOG1485">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_2_2_1"/>
    <dbReference type="InParanoid" id="Q2GW93"/>
    <dbReference type="OMA" id="CWALRNQ"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000003">
        <property type="entry name" value="Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF12">
        <property type="entry name" value="CATION DIFFUSION FACILITATOR 1 (AFU_ORTHOLOGUE AFUA_1G14440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="193"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="10">
        <location>
            <begin position="392"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ86508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="478" mass="52559" checksum="246C7B3CB085E9FF" modified="2006-03-21" version="1">MDPPDLSNSISLHPHPFRTQSDSASRLARTQSPRPSSMTGNGASTGVEPTEGGDEGAVARHPPSAPGDVEVESQRAGRFSPSSAPANDPYGLSQRYKTASELAEIKANTSRKRDAAHQPSPTVTAKASTTSTLAGYIKPFGRKATTARRLEGFYQAQNETIERLLKSVEEHRAEARQEQGEDHLKFKIAIWGSLVANIILTGLQLYAAISSGSLSLFTTMADAIFDPLSNVTLILTNRAVRRVDPARFPSGKARLETVGNIVFCFLMTAVSLIIIAFAARELSESADELKPFFLPSIISVCIAFGTKLTLFLYTWSIKDKYSQVRILWQDHRNDLLVNGFGILTSVGGSKLVWWLDPAGAIVLSVVITSLWLRTAFTEFLLLVGVVAPVEIQQLITYVCLTHSPAIRQIDTVRAYHSGPRLIAEVDVVMDPDATLQETHDIAEELQIKLERLPDIERAYVHVDYETTHKPEHAFKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWG5</accession>
    <name>Q2GWG5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_07689</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225345.1">
        <property type="nucleotide sequence ID" value="XM_001225344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWG5"/>
    <dbReference type="FunCoup" id="Q2GWG5">
        <property type="interactions" value="419"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GWG5"/>
    <dbReference type="GeneID" id="4393602"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07689"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055356_2_1_1"/>
    <dbReference type="InParanoid" id="Q2GWG5"/>
    <dbReference type="OMA" id="ETYYCFN"/>
    <dbReference type="OrthoDB" id="1298661at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016958">
        <property type="entry name" value="DUF858_MeTrfase_lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016958-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ86436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="233" mass="25655" checksum="FAE251F4BC55F2EB" modified="2006-03-21" version="1">MTSNDLKTENVDSLINRDDGRKYWESTDATVDGMLGGHPHVSRVELRGSRNFLAKIGIGSKPGQQVAINALEGGAGIGRVTEGLLLGGIAQHVDIIEPIAKFTAQLQGKPGVRNIFNMGLEDWQPGDGVQYDLIWIQWCAAYLTDKQLVQFLERCKSALNPDRGVIVFKENTSPVGKDMFDDVDSSVTRGDDTYRRCFTAAGFRLIKTELQKGLVSGVKLMPVRMYALRPVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWH6</accession>
    <name>Q2GWH6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="7">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_07678</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="7"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225334.1">
        <property type="nucleotide sequence ID" value="XM_001225333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWH6"/>
    <dbReference type="FunCoup" id="Q2GWH6">
        <property type="interactions" value="363"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GWH6"/>
    <dbReference type="GeneID" id="4393598"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07678"/>
    <dbReference type="eggNOG" id="KOG3964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030471_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GWH6"/>
    <dbReference type="OMA" id="WLWDARY"/>
    <dbReference type="OrthoDB" id="10250191at2759"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000850">
        <property type="entry name" value="Phospholipase_D_PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ86425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="340" mass="37681" checksum="C20A5D072A483CD3" modified="2006-03-21" version="1">MKLYGVDDEIILSGANLSSDYFTNRQDRYHLFSSKDVTEYFANIQDAVSSLSFLVKPSESQAGFEMIWPEDNAAPSPLEDPTHFVKESTSLLAGLVSPKTAPLTAHDTTPRDKRDTSVFLLSQFSQLLSPDTSTELPAVTHVLKTLSLPQYANSSWTFTAGYFNPAPSLTKLLLSTQSHGNTVITASPFANGFYKSPGVSGLLPDAYTLLARRFVRAVHQQQLEASTVLREWRKGTVGEPGAWTYHAKGLWITLPGSKDPSISLIGSSNYTKRSYSLDLETNAMIVTENEELKKRLGQEQRWLQEHTTIVTRDDFAKADRRVGIKVRLAMMMVKLLGGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXB4</accession>
    <name>Q2GXB4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Cutinase</fullName>
            <ecNumber evidence="3 13">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_07390</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cutinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3 13"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225046.1">
        <property type="nucleotide sequence ID" value="XM_001225045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXB4"/>
    <dbReference type="ESTHER" id="chagb-q2gxb4">
        <property type="family name" value="Cutinase"/>
    </dbReference>
    <dbReference type="GeneID" id="4393973"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07390"/>
    <dbReference type="eggNOG" id="ENOG502SI38">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040058_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GXB4"/>
    <dbReference type="OMA" id="ACKPITF"/>
    <dbReference type="OrthoDB" id="3225429at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000235">
        <property type="entry name" value="Cutinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043579">
        <property type="entry name" value="CUTINASE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF3">
        <property type="entry name" value="CUTINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00129">
        <property type="entry name" value="CUTINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00155">
        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00931">
        <property type="entry name" value="CUTINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 13" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013130602" description="Cutinase" evidence="14">
        <location>
            <begin position="16"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="52"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="191"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ86137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="230" mass="23572" checksum="60FE6EA4B1AE764F" modified="2006-03-21" version="1">MKFVQILSAAGLAAALPATTPANDMADVMARQWGGSIGSTKNDLQNGNSASCPSVIFIFARASTERGNMGSSTGPAVANALAKTYRDMWVQGVGGPYDATLGDNALPAGTSKAAIDEAVKMFTMAHDKCPDAAVVAGGYSQGTAVMSNSLGQLPAEVQDQVKGVVLFGYTKNAQNGGKIPDFPDDKLKVFCNTGDRVCTGSLVITAAHFAYGGVAGNEAPAFLKEKIGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXG9</accession>
    <name>Q2GXG9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Branchpoint-bridging protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CHGG_07335</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the BBP/SF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224991.1">
        <property type="nucleotide sequence ID" value="XM_001224990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXG9"/>
    <dbReference type="STRING" id="306901.Q2GXG9"/>
    <dbReference type="GeneID" id="4394162"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07335"/>
    <dbReference type="eggNOG" id="KOG0119">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016864_3_0_1"/>
    <dbReference type="InParanoid" id="Q2GXG9"/>
    <dbReference type="OMA" id="PGMPSMY"/>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045131">
        <property type="term" value="F:pre-mRNA branch point binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02395">
        <property type="entry name" value="KH-I_BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000030">
        <property type="entry name" value="Branchpoint-bridging protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000024">
        <property type="entry name" value="Branchpoint-bridging protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032570">
        <property type="entry name" value="SF1-HH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047086">
        <property type="entry name" value="SF1-HH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF45">
        <property type="entry name" value="SPLICING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16275">
        <property type="entry name" value="SF1-HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="11 16" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 16" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="9 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="19">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="19">
        <location>
            <begin position="340"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="354"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="401"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="261"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="506"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="522"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="546"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="576"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EAQ86082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="603" mass="63591" checksum="6B4FD068172BB99A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXM3</accession>
    <name>Q2GXM3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear protein DGCR14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_07281</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESS2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EAQ86028.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001224936.1"/>
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    <dbReference type="AlphaFoldDB" id="Q2GXM3"/>
    <dbReference type="STRING" id="306901.Q2GXM3"/>
    <dbReference type="GeneID" id="4394427"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07281"/>
    <dbReference type="eggNOG" id="KOG2627">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024820_0_0_1"/>
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    <dbReference type="OMA" id="AQNDYLD"/>
    <dbReference type="OrthoDB" id="19679at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019148">
        <property type="entry name" value="Nuclear_protein_DGCR14_ESS-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940">
        <property type="entry name" value="ES-2 PROTEIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940:SF0">
        <property type="entry name" value="SPLICING FACTOR ESS-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09751">
        <property type="entry name" value="Es2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
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        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
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        <location>
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            <end position="188"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="377"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ86028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="48832" checksum="5B1602C8A4E6C1AF" modified="2006-03-21" version="1">MESSAHAQSTALIRKRTETELMPPPPPAKRIKRPKRVLDENTYTDALSHIIARDFFPGLLESETQQEYLDALESKDEEWIDSASRRLRQVMTPGRRRGLATPLRQATAAGGHTPLNFVGDTPASVVSTATVTTSAQKQPAIDTSVSLAMFQSKYTSEDNESFYKLLDKQNQKRPSGAPAPSETTDSPAIDWAILDKDAVDRPAAPDHWNKAKPDNELMFVPDGVDGSELQTVAERAQAESRAPPKRIVYENTRMPQPAAREVSGEGDRSSRAGSPSLSEIRNAIAGNRRACDAETSVTGGAGETPRVNGYAFVDDEEPEPEPEPARLKRDKMPVIDLGPGDATPNPFQFQEQRKREALHHRMVDKISLSKRTSARLGFTGNVGRTPVPKFPSSPRVSGGDLTPAAQRLWGRIGGSERRGAASPFSDSIKSTPKATPVGKRSGLRNLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-09-13" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GY33</accession>
    <name>Q2GY33_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224777.1">
        <property type="nucleotide sequence ID" value="XM_001224776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GY33"/>
    <dbReference type="GeneID" id="4393374"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07121"/>
    <dbReference type="HOGENOM" id="CLU_2812121_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GY33"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208574" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7441" checksum="E522ED67A2E3BEB2" modified="2006-03-21" version="1">MVWLLWIVFFSELHVVQLLGCDVGPGAEVAKGDLRCLLACAAGACVQVVREHVFGRDLEMQYGHNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GY47</accession>
    <name>Q2GY47_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_07107</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224763.1">
        <property type="nucleotide sequence ID" value="XM_001224762.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GY47"/>
    <dbReference type="GeneID" id="4393192"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07107"/>
    <dbReference type="eggNOG" id="KOG2029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_1_1"/>
    <dbReference type="InParanoid" id="Q2GY47"/>
    <dbReference type="OMA" id="CHCTIAN"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
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    </dbReference>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="65" xmlns="https://uniprot.org/uniprot">
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        <location>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ85692.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1071" mass="115148" checksum="17B308982FBF4BE4" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYX0</accession>
    <name>Q2GYX0_CHAGB</name>
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        <recommendedName>
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            <taxon>Sordariomycetidae</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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        <text evidence="9">Belongs to the glycosyl hydrolase family 6.</text>
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    </dbReference>
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        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glyco_hydro_6_CS"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glyco_hydro_6"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005142948" description="Glucanase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6 8">
        <location>
            <position position="169"/>
        </location>
    </feature>
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        <location>
            <position position="347"/>
        </location>
    </feature>
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        <location>
            <position position="81"/>
        </location>
        <ligand>
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        <location>
            <position position="214"/>
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        <ligand>
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        </location>
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        <location>
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        <ligand>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001100-2"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10057"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ85581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="381" mass="41068" checksum="BF5CCD15F80FD69B" modified="2006-03-21" version="1">MRPSCLLAALATGGLVSAAPSPKPPTPPAPGDVNPFQGKTQFVNPAWATKLGQTLRSFLRKGDLVNAAKTYKVQNTASFVWVSNRAGLSNIDDAIAAARKAQKKTGKKQIVGLVLYNLPDRDCSAGESAGEFHSDENGLQLYKDEFIKPYAQKVAAAKDLDFAIVLEPDSLANLVTNMGVELCANAAPVYREGIAHAIAELQHPHVHLYIDAAHGGWLGWDDNLPLAAKVFSEVVALAGKGKKIRGFVTNVSNYNPFNAVVRENYTEWSNSWDESHYATSLAPHLEAEGLPAHFIVDQGRVALPGAREEWGEWCNVEPAGFGPAPTTNTNNTVVDALVWVKPGGESDGECGLAGATRAGEWFDEYAQMLVKNADPSVFKWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZ55</accession>
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        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
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            <taxon>Sordariomycetes</taxon>
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            <authorList>
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                <person name="Untereiner W.A."/>
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            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <begin position="29"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="Pfam" id="PF24883"/>
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            <dbReference type="Proteomes" id="UP000001056"/>
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    <sequence length="529" mass="60453" checksum="CE93F9E74FD7CDD8" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZI1</accession>
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            <fullName evidence="2">DDE-1 domain-containing protein</fullName>
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            <taxon>Sordariomycetes</taxon>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="463"/>
        </location>
    </feature>
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        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
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        <location>
            <begin position="560"/>
            <end position="600"/>
        </location>
    </feature>
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        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="642" mass="72307" checksum="69CAC6D6EE0F4D7B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZT6</accession>
    <name>Q2GZT6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_04960</name>
    </gene>
    <organism evidence="7 8">
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001224173.1"/>
    </dbReference>
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    <dbReference type="STRING" id="306901.Q2GZT6"/>
    <dbReference type="GeneID" id="4393031"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04960"/>
    <dbReference type="eggNOG" id="KOG1649">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="VEVQGIW"/>
    <dbReference type="OrthoDB" id="10258327at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:chromatin remodeling"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SNF5"/>
    </dbReference>
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        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="55"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="236"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="431"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="597"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="432"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="511"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="598"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ88341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="630" mass="68967" checksum="4154C87B76064A3F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZZ7</accession>
    <name>Q2GZZ7_CHAGB</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224113.1">
        <property type="nucleotide sequence ID" value="XM_001224112.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000001056">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="142" mass="15757" checksum="3A0B398921FA780F" modified="2006-03-21" version="1">MPFSTRVPNTARSRAVPPAWSLPASVPGSRRPVYPIEEPSRGARAGDQEADEISAVDAEHETRDMTDQRHLLSHPSLEKAQSRPQAKGSVRAMAYNVSICTTDYLQCLTLRARNAESHPGYLDHDWSRAGTRRHVEPNISLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H031</accession>
    <name>Q2H031_CHAGB</name>
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        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001224078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H031"/>
    <dbReference type="GeneID" id="4392694"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04865"/>
    <dbReference type="eggNOG" id="KOG3947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041441_3_0_1"/>
    <dbReference type="InParanoid" id="Q2H031"/>
    <dbReference type="OMA" id="PHHDAWS"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF18">
        <property type="entry name" value="ESTER HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209156" description="Calcineurin-like phosphoesterase domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="68"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="335" mass="37961" checksum="E50E015A6640B48E" modified="2006-03-21" version="1">MFTLALHHLNTLLQLLHLRRASPWNPPTPLDWLLASPLQYLTQLLYRHVLLPLRGRPFHPPRGRRPIRVVCLSDTHNLIPGYAVPDGDVLVHCGDLTVGGTVAELQKQVDWLRGLGHRWKVVVGGNHDAWVDEGVREELGLGVGGEVDWTGVEYLCDRGVELEFEGGRRLNVYGWGAVPWCGEGFALQYQREKHPWQGRIPDETDLLVTHTPPRHHLDLGLGCAGLLDEVWRVKPKLHVFGHTHYGYGKEAVYYDECQRAYESLMSRPQRGPFYDMIPSARWTDAFNVFWYGVSNILWKWIMLGPGTNNGGLMANVSLMYGNSGKLRNPVTVVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H078</accession>
    <name>Q2H078_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_04818</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224032.1">
        <property type="nucleotide sequence ID" value="XM_001224031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H078"/>
    <dbReference type="STRING" id="306901.Q2H078"/>
    <dbReference type="GeneID" id="4392930"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04818"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014245_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H078"/>
    <dbReference type="OMA" id="FYWLAKY"/>
    <dbReference type="OrthoDB" id="9439903at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF12">
        <property type="entry name" value="RFEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0U9</accession>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223811.1">
        <property type="nucleotide sequence ID" value="XM_001223810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0U9"/>
    <dbReference type="GeneID" id="4392920"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04597"/>
    <dbReference type="eggNOG" id="ENOG502QUBE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047729_3_1_1"/>
    <dbReference type="InParanoid" id="Q2H0U9"/>
    <dbReference type="OMA" id="GMQCTGT"/>
    <dbReference type="OrthoDB" id="5418436at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021476">
        <property type="entry name" value="Egh16-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618:SF4">
        <property type="entry name" value="CAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618">
        <property type="entry name" value="SURFACE PROTEIN MAS1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11327">
        <property type="entry name" value="Egh16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208667" evidence="2">
        <location>
            <begin position="22"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="288" mass="28967" checksum="70EAA32C65E7D58C" modified="2006-03-21" version="1">MASTKTLLTLAFLATAQLVAGHGAIIAAVGDAGGTGMGLGVDTSTPRDGTRRRPFQQDSTRFRGDAADTVGETIGAGDNQLEAGTTAIMAETGDSLPQVTAGGELQMTLHQVNGDGAGPYTCMINADGTAQTWTNIQVTQNVPGRNSRNRDGSATDFPLVASIPATQTCTGTVAGQEDVCLVRCQNSARAGPFGGVVPVQMVNDNAGAGAGNGAAGNGTADAGTGAGTGAGGDAAANASTRAKNARRALARRVRESEAKLARLRNRAVALAEDLGDPDVLAEVLEDCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H180</accession>
    <name>Q2H180_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anthranilate phosphoribosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_04466</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223680.1">
        <property type="nucleotide sequence ID" value="XM_001223679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H180"/>
    <dbReference type="FunCoup" id="Q2H180">
        <property type="interactions" value="263"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H180"/>
    <dbReference type="GeneID" id="4393082"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04466"/>
    <dbReference type="eggNOG" id="KOG1438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034315_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H180"/>
    <dbReference type="OMA" id="GPMTNPA"/>
    <dbReference type="OrthoDB" id="427800at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1030.10:FF:000010">
        <property type="entry name" value="Anthranilate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285:SF2">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 3 N-terminal" evidence="4">
        <location>
            <begin position="27"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 3" evidence="3">
        <location>
            <begin position="106"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ87847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="46037" checksum="9C617759390B22E5" modified="2006-03-21" version="1">MAPPTEDQPLVNLKPLLARLWPLGHPDPVSPVEIAEAISHFFTNQVSEVQAGALLMCLHFTGLDRQAEVLAKTAECMLKSAAKIDQPLLRAAIDARRRKEGQYEGGLVDIVGTGGDSHNTFNISTTASIIASSLLLIAKHGNRASTSKSGSADLLNCMQPQPPQIDRIRPDTIAELYSNTNYGFLFAPVFHPGMRHVAPIRKQLPWRTIFNLVGPLANPTDLRDPTQPAGADPLLEARVIGVARKDIGPVFAHALRLGGARKAMVVCGDEELDEISCAGDTLCWRIRPADDGDGTSSGGGEEAITEHFRLHPRDFGLPAHPLSAVSPGKEPHENAGILRRILDGHVPDDDPILHFVLINAAALFVVSGICEADTSDLGHGDDGAVVTERGPGGGRWKEGVRRARWAIKSGEAARQWAKFVEVTNSFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2A1</accession>
    <name>Q2H2A1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF895 domain membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_04095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223309.1">
        <property type="nucleotide sequence ID" value="XM_001223308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2A1"/>
    <dbReference type="GeneID" id="4391922"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04095"/>
    <dbReference type="eggNOG" id="KOG3098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030884_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H2A1"/>
    <dbReference type="OMA" id="YMFVYWL"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF57">
        <property type="entry name" value="CINA C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ87476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="50602" checksum="1B0E367933DDBAED" modified="2006-03-21" version="1">MSSTEENLEKKIDDPNALEVAGTAEEQIKPVSRFMRWYRSPLSNVILVGLISFTQPGIWNALNSTGAGGQQEPYLVNGSNALTFGIGVKKVLIIGTLGYAPYSASLYVNNRYGTEWFVLFGGATCGIAASALWASEGAIALGYGDVKDRGKFAGIWLGLRELGQLIGASIQLSLNVGTSSRGKVGYSTYLVLIALQCLGLPLAFLISPPEKVIRSDGTRGRVAAKDTTLKEEMHKTWKLLKRKEMFLLVPILIGFQWNSTYLGIYMTKYFSVRARTLGALVSGIVATLANIFWGWFYDLRYFSRPTLAKACWLFFVVSMLGTFGWQVANEKLYGDSNPRVTLDWENSGFGRGFGSMVILRFLNESHYMYVYWIVGAFFDDMETLTLAVSLVRTFESIGSSISFGIGAAAVSPMVNLVISFAMFGLTIPATSLVVFMVPERPVDLRKDDKVLTSGEESERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2I1</accession>
    <name>Q2H2I1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sas10 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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        </location>
    </feature>
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            <end position="374"/>
        </location>
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        </location>
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        </location>
    </feature>
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    </feature>
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            <end position="364"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="41069" checksum="C49380182A4871A6" modified="2006-03-21" version="1">MAAPATLPALLDSLTKSITTTLEVAPKLAGAELPKDGISLLDVKNELLLAYLQNLVFLILLKLRQARNGDSSNDAGDQNLDDLVVSKLVELRLYLEKGARPLEDKLRFQIDKVLRAADDAERNAKAAEEAAKSDGHGSESESGSEEGESDEEEDDQGAVDGRKIADLQHRPNLGGFQRPAAAVYSGKETDASGVYRPPKIAPVVMPTTERREKAERRVGKSATLDEFIVDEMSTAPIAEPSIGTTIVNFGRKVKTASERRKEDERREFEETNFVRLPKESKKDRAKRAKQEGGSRRMNFGGEEWRDLSEGVDRISRLTQGKRTGGGTKALLEKSRKRGIDTTDGPRGNGANMGERYQKRLKVVESGRGTRGKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2Q2</accession>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="213" mass="23280" checksum="B88178D78225AB09" modified="2006-03-21" version="1">MTTTKTPPSPAAAALNDTSILPRRIASIALVVLLYTAATPFAPVSWLTGPVSLSGTYFLDRLVAGLVLFCAFYFQWAIASLRAAVVVSLPTGGSTARVLRNGRLEHDPASAGSVPLWVWRTADYWHFALAEVAVLLVAEFGGSETMRRLLVLGVILFLWVVGWAATPASLKRWAWEHIKVYLFVLVLDELRNIGYGALQGMAGGGQRRRRGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2Q7</accession>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    </dbReference>
    <dbReference type="GeneID" id="4392626"/>
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    <dbReference type="eggNOG" id="KOG0017">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:aspartic-type endopeptidase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
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        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
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        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
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        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
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        <property type="entry name" value="RNaseH_sf"/>
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        <property type="entry name" value="RT_dom"/>
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        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
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        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RT_RNaseH_2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
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    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="16">
        <location>
            <begin position="1011"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="1573"/>
            <end position="1733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="230"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="277"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="546"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="658"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="762"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1855"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="552"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1883"/>
            <end position="1892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ87320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1892" mass="215290" checksum="15E0BEA97085DE6B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H305</accession>
    <name>Q2H305_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phosphotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_03841</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223055.1">
        <property type="nucleotide sequence ID" value="XM_001223054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H305"/>
    <dbReference type="GeneID" id="4392679"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03841"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_301136_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H305"/>
    <dbReference type="OMA" id="SHEIVWG"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004396">
        <property type="term" value="F:hexokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24000">
        <property type="entry name" value="ASKHA_NBD_HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF67">
        <property type="entry name" value="MFS MULTIDRUG EFFLUX TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="581"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="657"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="688"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="739"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="827"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="852"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="899"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="964"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase N-terminal" evidence="12">
        <location>
            <begin position="68"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="13">
        <location>
            <begin position="179"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="457"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="525"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ87222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="991" mass="107427" checksum="56F9CD95C18A0447" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3K2</accession>
    <name>Q2H3K2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein HRI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_06763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222858.1">
        <property type="nucleotide sequence ID" value="XM_001222857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3K2"/>
    <dbReference type="GeneID" id="4390045"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06763"/>
    <dbReference type="eggNOG" id="ENOG502SQVR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036200_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H3K2"/>
    <dbReference type="OMA" id="ERCITFH"/>
    <dbReference type="OrthoDB" id="4561120at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ90144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="44645" checksum="C3A12A2164B9F973" modified="2006-03-21" version="1">MAVNHQIWPMDDLLAPYIRLTEADRLPHTPRVRLCMEAPPRLSTTLPYDISFYLQREDDDPRHCMIIWNAALDILIPSNLILLHHITNADGGLELERVDVEPDPTAEFRTPGANVKEKLPKLVMPGGSRLGFAAGTEAVPWPGREEHEARLGFASANDAELVWRWGEAKKRRAPDFVKASERVPGAPILVVTLDCPRELTLHKSRPGSSTFEVRAKVTYDAPASEKPITFRACDLWQSGSIGLRSRREGYEFYRYHKLDEGSDEQAWQVCEIDDEEEGCGIFDFDGPDIKVHIQEESDFISLRPGEFWTTAYQIQTPTDTRLPKDTKVGDRFRYRFLGATGVDWWDWGHVEDEHAETVVSLPSWRGRVVQPADNGGRPKLVVPASDHVEFRVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3Y1</accession>
    <name>Q2H3Y1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_06634</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:exocytosis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="279"/>
        </location>
    </feature>
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        <location>
            <begin position="39"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="423"/>
        </location>
    </feature>
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        <location>
            <begin position="590"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="735"/>
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        </location>
    </feature>
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        <location>
            <begin position="39"/>
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    </feature>
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        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
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        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
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        <location>
            <begin position="605"/>
            <end position="643"/>
        </location>
    </feature>
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        <location>
            <begin position="742"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ90015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="799" mass="87061" checksum="1D1EC6861155D9F1" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3Z0</accession>
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        </submittedName>
    </protein>
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        <lineage>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
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    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502SWZV">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ90006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="157" mass="16906" checksum="67FB940507296AD2" modified="2006-03-21" version="1">MLQPFSKTAVAVTTRAATRRAPTAKPATASRPFSSSSQSQSRSPPPTSSTRPTRTTTRTTATTEAQAQAQAKAEATQKIRRIILTVSFAAVIFTGTIYGAGLKTQQEWKAEKKKVQEASVDEKVAMLERQKLDMLRQKTEIESKVANPAKGGRGGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4H8</accession>
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        <recommendedName>
            <fullName evidence="5">DsDNA-binding protein PDCD5</fullName>
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    </gene>
    <organism evidence="3 4">
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDCD5 family.</text>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122978_1_0_1"/>
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    <dbReference type="OMA" id="MQYEMQK"/>
    <dbReference type="OrthoDB" id="10252486at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.140:FF:000007">
        <property type="entry name" value="DNA-binding TFAR19-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.140">
        <property type="entry name" value="PDCD5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
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        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
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    </dbReference>
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        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="12"/>
            <end position="53"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="15188" checksum="737A41290DD781F1" modified="2006-03-21" version="1">MADADLEQIRKARLEQLKTQGGGGGSASGGSSGQEQQAQKQQQEAEARKSVLNQILEPDAADRLGRIRLVKEQRATDVENRLIMLAQTGQLRQKVTETQLKDLLNAMVDNQEQEKIVVTRRKGWDDDEDDDELFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4J3</accession>
    <name>Q2H4J3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_06422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222517.1">
        <property type="nucleotide sequence ID" value="XM_001222516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4J3"/>
    <dbReference type="STRING" id="306901.Q2H4J3"/>
    <dbReference type="GeneID" id="4390620"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06422"/>
    <dbReference type="eggNOG" id="KOG0417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_13_2_1"/>
    <dbReference type="InParanoid" id="Q2H4J3"/>
    <dbReference type="OMA" id="AEPHEDN"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="113" mass="12433" checksum="4305E3C047857AD9" modified="2006-03-21" version="1">MALPKRIIKETERLMAEPVPGISAVPHEDNLRYFDVEIHGPSSSPYEAKAYRIPDNWSPALQIRTILLSIQALLGAPNPDDPLAADVAKSWKEDEAGAIATAKAWTQQYAVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5F0</accession>
    <name>Q2H5F0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Solute carrier family 40 member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_06115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in iron transport and iron homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222210.1">
        <property type="nucleotide sequence ID" value="XM_001222209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5F0"/>
    <dbReference type="GeneID" id="4390333"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06115"/>
    <dbReference type="eggNOG" id="KOG2601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1098381_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5F0"/>
    <dbReference type="OrthoDB" id="648861at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009716">
        <property type="entry name" value="Ferroportin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660:SF57">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06963">
        <property type="entry name" value="FPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ89496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="253" mass="28039" checksum="C98CC7E51E41D967" modified="2006-03-21" version="1">MGLPLGHGGRTGMLVLLSFLACIEKLCSILNLVSVEKDWVVVVADQDHAALMTMNAQMRRIDLLCNLFGPLFIALLDGVSTKVAITANLVMNVTSVVLEYFAIARVYYEVPRLQQAKVAPRREPTEIEPARVPESRSQLAQSWRRARGVFSKSARDFNFYFRHRAFLASISGALLYLTVLSFAGQMVTYLLSAGYTSNQVGITRTLSVFFEVLATWVAPWLMGRVGPFKSCPGGRDREPRCIFISGSGVAKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6N0</accession>
    <name>Q2H6N0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221780.1">
        <property type="nucleotide sequence ID" value="XM_001221779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6N0"/>
    <dbReference type="STRING" id="306901.Q2H6N0"/>
    <dbReference type="GeneID" id="4390324"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05685"/>
    <dbReference type="eggNOG" id="KOG2319">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017705_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6N0"/>
    <dbReference type="OMA" id="ETAYCLV"/>
    <dbReference type="OrthoDB" id="10264848at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF97">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="247"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="575"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="694"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="799" mass="85631" checksum="1E7ADDD9AC561BEE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H791</accession>
    <name>Q2H791_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glucan 1,3-beta-glucosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_05474</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221569.1">
        <property type="nucleotide sequence ID" value="XM_001221568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H791"/>
    <dbReference type="STRING" id="306901.Q2H791"/>
    <dbReference type="GeneID" id="4390985"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05474"/>
    <dbReference type="eggNOG" id="ENOG502SI3D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028820_0_2_1"/>
    <dbReference type="InParanoid" id="Q2H791"/>
    <dbReference type="OMA" id="WDVWGNA"/>
    <dbReference type="OrthoDB" id="77201at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF16">
        <property type="entry name" value="GPI-ANCHORED CELL WALL BETA-1,3-ENDOGLUCANASE EGLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="454"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="458"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ88855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="58542" checksum="3AC104B597D8C5AB" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7E5</accession>
    <name>Q2H7E5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221515.1">
        <property type="nucleotide sequence ID" value="XM_001221514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7E5"/>
    <dbReference type="GeneID" id="4390233"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05420"/>
    <dbReference type="eggNOG" id="ENOG502SM92">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_498741_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7E5"/>
    <dbReference type="OrthoDB" id="4566097at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209019" evidence="1">
        <location>
            <begin position="18"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="546" mass="61414" checksum="CC72E454AF388EAF" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7X4</accession>
    <name>Q2H7X4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Beta-xylanase</fullName>
            <ecNumber evidence="11">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_03680</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="11"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230196.1">
        <property type="nucleotide sequence ID" value="XM_001230195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7X4"/>
    <dbReference type="GeneID" id="4388750"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03680"/>
    <dbReference type="eggNOG" id="ENOG502QR4K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020161_5_0_1"/>
    <dbReference type="InParanoid" id="Q2H7X4"/>
    <dbReference type="OMA" id="TIWDFYD"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF35">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208913" description="Beta-xylanase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="13">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ91745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="315" mass="35092" checksum="D066515D37F43C4F" modified="2006-03-21" version="1">MHLPSSLLFLASLPLGMAAGKGKGNGPKTGLDWLFAEPAHGQFNFTEGDIVTSLARENGMYLRCHALVWHSQLAPWVESTEWTPEELRQVVVDHITNVMGHYKGQCYAWDVVNEALNEDGTYRESVFYNVLGEDFLKLAFETASKVDPKAKLYYNDYNLEWPSAKTEGAQRIVKLLKDDGIRIDGVGLQAHLVAEDHPTLDQHIDAIKGFTKLGVEVALTELDIRLQTPATPENLELQKQAYKNVCGCIGVTIWDFYDPFSWVPFVFEGEGAALLWFEDFSKHPAYDGVVEALTNRTTGVGKGKGKAKRATIWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8P2</accession>
    <name>Q2H8P2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_03412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229928.1">
        <property type="nucleotide sequence ID" value="XM_001229927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8P2"/>
    <dbReference type="STRING" id="306901.Q2H8P2"/>
    <dbReference type="GeneID" id="4389766"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03412"/>
    <dbReference type="HOGENOM" id="CLU_1294245_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8P2"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ91477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="213" mass="24138" checksum="2E99FCD71FF7D581" modified="2006-03-21" version="1">MVFVDTIFAEYQGKRYFGNWQKLSAWSLTDYERIVLLDSNHLILHPIDDLQTLLFSHGLHHSGGDRNDYIAAVLTAPGHPHPSTIILHPSLAQYQRLRSTLNEFFFSRANEQDVLVMAYRGRVASLLGGYSALESKWGGYVSDDGARVKVRLYDLGRPWEKREGRGAVREWLDVWREVRGEWVGDGMLSGVGLGDGRRRLWERVLGPMVGGGL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-07-27" modified="2025-06-18" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8T2</accession>
    <name>AMPP1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Probable Xaa-Pro aminopeptidase P</fullName>
            <shortName>AMPP</shortName>
            <shortName>Aminopeptidase P</shortName>
            <ecNumber>3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">AMPP</name>
        <name type="ORF">CHGG_03372</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229888.1">
        <property type="nucleotide sequence ID" value="XM_001229887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8T2"/>
    <dbReference type="SMR" id="Q2H8T2"/>
    <dbReference type="FunCoup" id="Q2H8T2">
        <property type="interactions" value="346"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H8T2"/>
    <dbReference type="MEROPS" id="M24.009"/>
    <dbReference type="GeneID" id="4388486"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03372"/>
    <dbReference type="eggNOG" id="KOG2413">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011781_2_2_1"/>
    <dbReference type="InParanoid" id="Q2H8T2"/>
    <dbReference type="OMA" id="EPGMILS"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000010">
        <property type="entry name" value="Probable Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000003">
        <property type="entry name" value="Xaa-pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0031">Aminopeptidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000411786" description="Probable Xaa-Pro aminopeptidase P">
        <location>
            <begin position="1"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="544"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="544"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="624" mass="68186" checksum="D3CC4ED836CB34F2" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8X7</accession>
    <name>Q2H8X7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CWF21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_03327</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229843.1">
        <property type="nucleotide sequence ID" value="XM_001229842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8X7"/>
    <dbReference type="FunCoup" id="Q2H8X7">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H8X7"/>
    <dbReference type="GeneID" id="4389552"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03327"/>
    <dbReference type="eggNOG" id="KOG1869">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067891_2_1_1"/>
    <dbReference type="InParanoid" id="Q2H8X7"/>
    <dbReference type="OMA" id="LAHMRPR"/>
    <dbReference type="OrthoDB" id="10267305at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21372">
        <property type="entry name" value="cwf21_CWC21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CWF21" evidence="8">
        <location>
            <begin position="56"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="148"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ91392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="189" mass="21850" checksum="C0E408E7DF2C0362" modified="2006-03-21" version="1">MSDNVGLSTPRGSGTSGYVQRNLAHMRPRDNAAPYAPRNDVDTLRHKPRQPDKGLLEHERKREVEVKVFELRDKLEEEEVDEEEIDSRCGELRKKLLAEMEKNQAGDGRRGGVGPKRNLKMHQVHELADAKIKESERLRQALKISKDYEEGGHWRRQEERLKKSLEQEAGGVTDGVKDEGERERSRDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9A2</accession>
    <name>Q2H9A2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cleavage and polyadenylation specificity factor subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nudix hydrolase family. CPSF5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229718.1">
        <property type="nucleotide sequence ID" value="XM_001229717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9A2"/>
    <dbReference type="STRING" id="306901.Q2H9A2"/>
    <dbReference type="GeneID" id="4389072"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03202"/>
    <dbReference type="eggNOG" id="KOG1689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068704_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9A2"/>
    <dbReference type="OMA" id="NDEWEIG"/>
    <dbReference type="OrthoDB" id="277288at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18871">
        <property type="entry name" value="NUDIX_Cfim25_Nudt21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000005">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016706">
        <property type="entry name" value="Cleav_polyA_spec_factor_su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13047">
        <property type="entry name" value="PRE-MRNA CLEAVAGE FACTOR IM, 25KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13869">
        <property type="entry name" value="NUDIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017888">
        <property type="entry name" value="CPSF-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR017888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="265" mass="29996" checksum="6880E64C0836ED3E" modified="2006-03-21" version="1">MSTITPTALQSTQPPIIPLNFNGNQPETIRLYPLSNYTFGVKETQPEEDPSVLARLKRLEEHYQAHGMRRTCEGILVCHEHNHPHILMLQIANAFFKLPGDYLRPEDDEVEGFKARLDERLAPVGSLGEGNKAADWQVGDCLAQWWRPNFETFMYPFVPAHITRPKECKKLYFIQLPHSKVLSVPKNMKLLAVPLFELYENTQRYGPQLSAIPHLLSRYNFEFVNEDGEVVAMTPGSGPTDGEVPKTKVLAGGDDIDMKTENGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9H6</accession>
    <name>Q2H9H6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229644.1">
        <property type="nucleotide sequence ID" value="XM_001229643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9H6"/>
    <dbReference type="STRING" id="306901.Q2H9H6"/>
    <dbReference type="GeneID" id="4388378"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03128"/>
    <dbReference type="eggNOG" id="ENOG502REH8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027433_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9H6"/>
    <dbReference type="OMA" id="WIAHHSG"/>
    <dbReference type="OrthoDB" id="3508621at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="621"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="658" mass="70922" checksum="7620B22888AFFC8B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9M3</accession>
    <name>Q2H9M3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229597.1">
        <property type="nucleotide sequence ID" value="XM_001229596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9M3"/>
    <dbReference type="STRING" id="306901.Q2H9M3"/>
    <dbReference type="GeneID" id="4389346"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03081"/>
    <dbReference type="eggNOG" id="ENOG502S1P2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052213_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H9M3"/>
    <dbReference type="OMA" id="KWSARFW"/>
    <dbReference type="OrthoDB" id="10005898at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="346" mass="36757" checksum="1D1774DE8F04A95B" modified="2006-03-21" version="1">MADAAPEVDVPAPAPIADLPSGDPIPSSTPPSKPPKRQPLPLGALLAALPSNLDSFLVRLEKCLSTPSGIDTVMLFLCYASKLSGSVLSSLSQSALRRSAREWIALVAALPRGNTRRLLLARRGPPQPGGGKTALPTFRRARPSSSPSASPRSPSLLSEARMIMRLLVAARHVFLGRACLLPPPPSPPAAPPQTPPPPPPPTNPPPPPPPPANWPPSSNTSASRSASPSSRSKTARTCPRGGSCRGRRRSRGGRSKWSARFWAAYVGIEIGRLAAERFGPTGARAFKTKTKQEKSEWTKKTVRQLAWAPLTLHWESDKGLVSDTTVGVLACIPGVIQMRDLWASTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9P4</accession>
    <name>Q2H9P4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ecp2 effector protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229576.1">
        <property type="nucleotide sequence ID" value="XM_001229575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9P4"/>
    <dbReference type="STRING" id="306901.Q2H9P4"/>
    <dbReference type="GeneID" id="4389084"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03060"/>
    <dbReference type="eggNOG" id="ENOG502T5P8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089018_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9P4"/>
    <dbReference type="OMA" id="NCHPQGG"/>
    <dbReference type="OrthoDB" id="4589349at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35605">
        <property type="entry name" value="ECP2 EFFECTOR PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35605:SF1">
        <property type="entry name" value="ECP2 EFFECTOR PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209078" description="Ecp2 effector protein domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23196" checksum="6E5223409AC6875C" modified="2006-03-21" version="1">MTFTNLRSIALTSVLAAAAVAPPAAKDSPIEGYTIAPATWEFNGPDGQTVQLNGTAQEVVAQFDVLVPNSRAQLIASITAASTSTSRHDENSLLEKCYDETKLHCWVGHWDYARLSAIQDGIDYLNGVPGRPWHNPRPSTCARVSCSYGSAIYWCNDNRSRKELNSYQNIAHGADRIKNTCHEIFPSMTLTQGQIFYKDNWNVIVRGDDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAR7</accession>
    <name>Q2HAR7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229203.1">
        <property type="nucleotide sequence ID" value="XM_001229202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAR7"/>
    <dbReference type="GeneID" id="4389113"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02687"/>
    <dbReference type="HOGENOM" id="CLU_1855035_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HAR7"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="138" mass="15061" checksum="E439D95EC47C1D63" modified="2006-03-21" version="1">MYGVKKLGLALIRQGVAPLIQAHLCSEKHENWRGSFARQRRKTPLLPSGIRTRTDSAPLVNIIYQQVHRANGCRRSRKLATKTGMCGRHTRCTPYCAGSHVAQGRGCCADGSVPEGKRINPQGAKDSSPPLSEKQGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAU9</accession>
    <name>Q2HAU9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229171.1">
        <property type="nucleotide sequence ID" value="XM_001229170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAU9"/>
    <dbReference type="GeneID" id="4389722"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02655"/>
    <dbReference type="HOGENOM" id="CLU_1594327_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HAU9"/>
    <dbReference type="OMA" id="QAGRHAC"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050972">
        <property type="entry name" value="SDr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403:SF14">
        <property type="entry name" value="OS05G0225800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="167" mass="17363" checksum="1F3D7154910E2D3F" modified="2006-03-21" version="1">MPHFFYILNAYPLITAPAPAPARAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAGSRAHCVEPPRRGNRYSTCKLEGHALRHRGRSHLLKPVGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HB05</accession>
    <name>Q2HB05_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_02599</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229115.1">
        <property type="nucleotide sequence ID" value="XM_001229114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HB05"/>
    <dbReference type="FunCoup" id="Q2HB05">
        <property type="interactions" value="651"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HB05"/>
    <dbReference type="GeneID" id="4389893"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02599"/>
    <dbReference type="eggNOG" id="KOG0018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HB05"/>
    <dbReference type="OMA" id="KHMDFQR"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03275">
        <property type="entry name" value="ABC_SMC1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028468">
        <property type="entry name" value="Smc1_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="13">
        <location>
            <begin position="505"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="34"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="156"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="314"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="386"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="656"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1015"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ90664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1219" mass="139658" checksum="61A15D6BDBFB9256" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBG2</accession>
    <name>Q2HBG2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228958.1">
        <property type="nucleotide sequence ID" value="XM_001228957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBG2"/>
    <dbReference type="STRING" id="306901.Q2HBG2"/>
    <dbReference type="GeneID" id="4388917"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02442"/>
    <dbReference type="eggNOG" id="KOG2651">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016581_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HBG2"/>
    <dbReference type="OMA" id="LQAPYNW"/>
    <dbReference type="OrthoDB" id="10258156at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF0">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="442" mass="49832" checksum="954D50A155EA0165" modified="2006-03-21" version="1">MKTKKVHEVTHFAGYIDRLAEDAARASGAEFTHFVDFGSGQNYLGRTLASPPYSKHIVAVESKEANMASARDLDILSGLAEAVDPSLHHDEEALKRAAKELGISDEDIATIDLRPRKELQATYAVEKEKGTIEYVVGRLEHADLTDVLSQLRGQENEVRQEDLRMMAISIHSCGNLSHYGIRSMILNPCIRAVAIVGCCYNLLTEKLGPPTYKPPFSRPTLQPINARVARESERRDPQGFPMSERVSTYGGDGIRLNITARMMACQAPQNWTEEESGAFFTRHFYRAVLQKIFLDRGVISRVYHGEETGEESPFNSSTNPVIIGSLRKQCYTSLTAYVRGAIAKLTTNSDFSQYSQTIKEKLGDITDEEIARYEEAFRHRKRELSAVWSLMAFSACVVESLIVTDRWLFLREHADIVRDCWVETVFDYRESPRNLVVVGIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBJ2</accession>
    <name>Q2HBJ2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_02412</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228928.1">
        <property type="nucleotide sequence ID" value="XM_001228927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBJ2"/>
    <dbReference type="GeneID" id="4389825"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02412"/>
    <dbReference type="eggNOG" id="KOG0502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_2_1"/>
    <dbReference type="InParanoid" id="Q2HBJ2"/>
    <dbReference type="OMA" id="CYRGHDK"/>
    <dbReference type="OrthoDB" id="4583255at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="3">
        <location>
            <begin position="224"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="746"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="779"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="812"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="845"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="875"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="933"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="934"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ90477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="968" mass="106275" checksum="C8B74B9C702111B8" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBV0</accession>
    <name>Q2HBV0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="17">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CHGG_02304</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="17"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228820.1">
        <property type="nucleotide sequence ID" value="XM_001228819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBV0"/>
    <dbReference type="STRING" id="306901.Q2HBV0"/>
    <dbReference type="GeneID" id="4388568"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02304"/>
    <dbReference type="eggNOG" id="ENOG502SHMC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_388290_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HBV0"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027377">
        <property type="entry name" value="ZAR1/RTP1-5-like_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF19">
        <property type="entry name" value="GLYCOSYLHYDROLASE FAMILY 61-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13695">
        <property type="entry name" value="Zn_ribbon_3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01328">
        <property type="entry name" value="zf-3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0186">Copper</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="3CxxC-type" evidence="19">
        <location>
            <begin position="65"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EAQ90369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="711" mass="77963" checksum="2326B5386AB3A96D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCC0</accession>
    <name>Q2HCC0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_02134</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="7">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="7"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221355.1">
        <property type="nucleotide sequence ID" value="XM_001221354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCC0"/>
    <dbReference type="GeneID" id="4386198"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02134"/>
    <dbReference type="eggNOG" id="KOG3870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030117_2_1_1"/>
    <dbReference type="InParanoid" id="Q2HCC0"/>
    <dbReference type="OMA" id="SHFWTGP"/>
    <dbReference type="OrthoDB" id="541375at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097023">
        <property type="term" value="F:fructose 6-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103026">
        <property type="term" value="F:fructose-1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF6">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="9">
        <location>
            <begin position="25"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ93899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="411" mass="46026" checksum="8B6D97F7B1AE37BC" modified="2006-03-21" version="1">MASATRPEPPREVWTSEKGSMARETATTRWPKIVQNMVDDLEESFGQSDKEHVEEGRRIQATLRIIKGEIMQDNQLHPLSSDGCPDIQTYNAQLQSFGNITWHNCPWLFAECYLYRCVQTLFARSQFWRDYDIFARQKLSAFVASHTAVQELSERYVSLTEATGALTIAKATDDAETERLFFSEMTEMALWGNVTDLSLLSALTNNSLDHLRSLQGSAAIREGQARIVSNDVPAAWDHLRSRRGAPQRRVDVVLDNAGFELLTDLVYALYLLDAGLASAVKLHVKAMPWFVSDVTPRDIDVLLSALADPTVFPGASNLSVQELVRRMRACCESGIVSVAEHAFWTTGFDFQALPEVAPELHRDLLDSSLVVFKGDLNYRKLVRDAMAAYNAVQGRYWAAARGVEDSGIEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCD1</accession>
    <name>Q2HCD1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_02123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221344.1">
        <property type="nucleotide sequence ID" value="XM_001221343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCD1"/>
    <dbReference type="STRING" id="306901.Q2HCD1"/>
    <dbReference type="GeneID" id="4386377"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02123"/>
    <dbReference type="eggNOG" id="KOG2710">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022891_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCD1"/>
    <dbReference type="OMA" id="QCIDFWE"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="341"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="519" mass="56354" checksum="6EFE5882A31EAE0F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCM7</accession>
    <name>Q2HCM7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_02027</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221248.1">
        <property type="nucleotide sequence ID" value="XM_001221247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCM7"/>
    <dbReference type="STRING" id="306901.Q2HCM7"/>
    <dbReference type="GeneID" id="4388103"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02027"/>
    <dbReference type="eggNOG" id="KOG0742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004471_6_3_1"/>
    <dbReference type="InParanoid" id="Q2HCM7"/>
    <dbReference type="OMA" id="LHRNAMV"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF2">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7025" evidence="3">
        <location>
            <begin position="234"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase AAA-type core" evidence="2">
        <location>
            <begin position="535"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ93792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="715" mass="81430" checksum="8ADA3C6C6BD920C1" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDF3</accession>
    <name>Q2HDF3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_01751</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220972.1">
        <property type="nucleotide sequence ID" value="XM_001220971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDF3"/>
    <dbReference type="STRING" id="306901.Q2HDF3"/>
    <dbReference type="GeneID" id="4386905"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01751"/>
    <dbReference type="eggNOG" id="ENOG502RP3U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_574901_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HDF3"/>
    <dbReference type="OMA" id="NTWFTIV"/>
    <dbReference type="OrthoDB" id="3862662at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ93516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="475" mass="52306" checksum="EAF02C60135C1E80" modified="2006-03-21" version="1">MSATSSSPAAGSSPQSWSPARPQHNCIECKRLKRACDKGSPCSKCVKANRICEYKDPGDDGLYGPISTAKDIHSLTFGTLLEILINKPRVKEAVSLYFSGVNTWFTIIERASFERDLEANWGNLSAEKSAMALCMALVARPPNQKSSKGMGDTVYPTTKTILGLVQSKLPMSVHMLQAELLIAMYEFSQAMPQQAYMSLGHCLQMTKAFGWHNQGFWAIDKQMAKPAEMKLNAILCLLNVAYDQPYPMHTTGLAPRLPVPMPETIDQYFSATSPFQFGDQGQGFRDGTGDQINSMFFPEATSAWYLSNVLQQLSDPTACGLTDPKTLSSMIMIHLRTMTSMGWRVGTSYIALMKLHYSGLFGGIGPMPVMCQNHVQDVQIIRNITSVILGKAGKLVQSEDQLTSGAIDPSWEFAMYYASLLLISHGDNVLQDMNWAQKVDNLTYALDKNDTANQLKSNSTIALPVVPGNHLTSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDQ6</accession>
    <name>Q2HDQ6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SLC26A/SulP transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_01648</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220869.1">
        <property type="nucleotide sequence ID" value="XM_001220868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDQ6"/>
    <dbReference type="STRING" id="306901.Q2HDQ6"/>
    <dbReference type="GeneID" id="4388015"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01648"/>
    <dbReference type="eggNOG" id="KOG0236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_554326_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HDQ6"/>
    <dbReference type="OMA" id="AGCEWEW"/>
    <dbReference type="OrthoDB" id="409725at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052706">
        <property type="entry name" value="Membrane-Transporter-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310:SF4">
        <property type="entry name" value="AFR304WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310">
        <property type="entry name" value="SULFATE TRANSPORTER YBAR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="458"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="SLC26A/SulP transporter" evidence="6">
        <location>
            <begin position="86"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ93413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="492" mass="53957" checksum="03267A9EADFAF39A" modified="2006-03-21" version="1">MFSIAEPQLVAACGDASEVDETSPLLAVSSQEDAQCVDLESQKGVARRESFGSRMASILSLVSNPKHWDRNALWDNVVVAPVACFPAVVVGLLLNILDALSYGISMFYVSCIISQLTISTGSIFKGGVGSELIEVVPFFHNMAATITNTVGEDKPDAVIATTITSYALSSMFTGALFYLMAKFKAGYLISFIPHHILLGCIGGVGWFLVVTGFDVTARMDGGLKYDLDTLKRLVQADTVPLWIIPLTLGVILFYGQPRIRSKYFLSLYILAIPAAFYALTGVLNEPNLDRLRRRGWVFTGPPADEPWWHFYTLYKLDQVHWGAIAHCLPTMLALTFFSILHVPINVPSLALNLGKDDVDVDHELKLHGYSNFLSGLAGSIQNYLVYSNSLLFMRSGGNSRLAGIELAVFTFLIMLIGPSLIGFIPVMMVGVLIFDLGFELLCEAVWLPRKTLKPVEYFTVVTIILIMGIYNFMIGIGVGIVMGFMSAAFIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HE48</accession>
    <name>Q2HE48_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dihydroneopterin aldolase/epimerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220727.1">
        <property type="nucleotide sequence ID" value="XM_001220726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HE48"/>
    <dbReference type="STRING" id="306901.Q2HE48"/>
    <dbReference type="GeneID" id="4388149"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01506"/>
    <dbReference type="eggNOG" id="KOG2544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062068_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HE48"/>
    <dbReference type="OMA" id="PCLIGVN"/>
    <dbReference type="OrthoDB" id="5425486at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroneopterin aldolase/epimerase" evidence="2">
        <location>
            <begin position="173"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="354" mass="38226" checksum="FAF0226FE6D8D78A" modified="2006-03-21" version="1">MSIFSIRNLSTTTPLQHAGHDAWGRARKAQPCTVSAEVAFHAPFAAASARDALGDDTVHYGTLSKAVLGSVARFEGEVAAEVGEGSKVGVEGERSLRDVLGRVWGDLTGLELDGRVRDGDATAAFLDLNKVRLLSVTVVLPKASLLGDGVRLTASAVFNAAERGEMEGRAMALEVSRLKVPTLVGVNANERLAKQFVIATVTVEGFTRGEDAYTDIERDVVTAMDASSFETLEALGAHLTEAVLASRWREDGWQVCIRMEKPTAVPMADCPIVEVRTTWESLERQRARHHEAIEVSATNMIGKHFGECLANVGVDLGPCRVSQIPRRWVLLKGKLGPDDEVHDSLIDTVRPVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEB5</accession>
    <name>Q2HEB5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_01439</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220660.1">
        <property type="nucleotide sequence ID" value="XM_001220659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEB5"/>
    <dbReference type="FunCoup" id="Q2HEB5">
        <property type="interactions" value="1230"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HEB5"/>
    <dbReference type="GeneID" id="4387434"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01439"/>
    <dbReference type="eggNOG" id="KOG0358">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_9_1_1"/>
    <dbReference type="InParanoid" id="Q2HEB5"/>
    <dbReference type="OMA" id="HPAANMI"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03338">
        <property type="entry name" value="TCP1_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000010">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012717">
        <property type="entry name" value="Chap_CCT_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02342">
        <property type="entry name" value="chap_CCT_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ93204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="537" mass="56993" checksum="EA433DDBA768048C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEI1</accession>
    <name>Q2HEI1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Actin-related protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_01373</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Component of the NuA4 histone acetyltransferase complex, of the INO80 chromatin remodeling complex, and of the SWR1 chromatin remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the actin family. ARP4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220594.1">
        <property type="nucleotide sequence ID" value="XM_001220593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEI1"/>
    <dbReference type="FunCoup" id="Q2HEI1">
        <property type="interactions" value="258"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HEI1"/>
    <dbReference type="GeneID" id="4387391"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01373"/>
    <dbReference type="eggNOG" id="KOG0679">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_6_2_1"/>
    <dbReference type="InParanoid" id="Q2HEI1"/>
    <dbReference type="OMA" id="MTEAPWN"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000137">
        <property type="entry name" value="Actin-related protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ93138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="465" mass="50898" checksum="24B167B46F4365F2" modified="2006-03-21" version="1">MSQQPLSSSVQPTDIYGGDEVSALVLDPGYCNTRAGFAGEEIPKQVIPSSYIHVDGRDLFGDPSIAPRAGIEVRNYMNRDSVVEDWDAATRVWEHVLVQRLQPPRPTPPSKNGLNVGDNDGDVEMGENEDATDALEKPLAENPLLMTEAPWNSAKAREKAIEISMENWGCPAFWLSRAPVLAAFAAGKATALVIDVGGANTSVTAIHDGMVLKRSVQRSPAAGVWLSGQIRSMWESGDPKVDVVPSFMVENKKPVEAGAPADARLKTFDFPITDSFRAFEEERVLTEFKESVVEVWRGPGRYTAPGNEDYARSQPGRVFEMPDGFNQMWREQRYRVAEGMWDESAAFPAVGEEPGLTKAQTIPAMIKAALDGVDVDLRPNLLGHVVVTGSTSLLNGFNDRLNHELTAMYPGLKIKIHAAGLTSERRFGAWIGGSILASLGTFHQMWISKKEYDENGAGIVEKRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEJ8</accession>
    <name>Q2HEJ8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220577.1">
        <property type="nucleotide sequence ID" value="XM_001220576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEJ8"/>
    <dbReference type="GeneID" id="4386616"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01356"/>
    <dbReference type="eggNOG" id="ENOG502S450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073105_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HEJ8"/>
    <dbReference type="OMA" id="NGSTWRN"/>
    <dbReference type="OrthoDB" id="3467153at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208854" evidence="1">
        <location>
            <begin position="17"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="329" mass="36398" checksum="6FD05F8B6D410FAB" modified="2006-03-21" version="1">MKFFTPLALLISLASAHPQPNIATFEEQFINSLPLVSRSESSAGNTSAITLVGYKSIPIEPEHVADFEKDYFANVSLWGRNRIYDRQARAIRVYFPVAGALLPLGARGEHVEADLLGRVPSTHADDTLQLLGRGLHVLGRKRTDHVTGVEGNVVENGIIYLSEPAKPVRHVGRAVVYNFGGKELHSHGPSGHPHKRAESKKGCLQNHNGKNCSKAYGINKGRCKMNTKVCMDYNGVVTDCKNYSSGWKKYRNFVDSDCDVSLGKGHCWNEIIPEGNYRENLNWVVARTAFKVFSGHRDSYQPGASTLRGLRSGLFSRLGAMSELRSLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEP2</accession>
    <name>Q2HEP2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="9">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_01312</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate esterase 1 (CE1) family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220533.1">
        <property type="nucleotide sequence ID" value="XM_001220532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEP2"/>
    <dbReference type="GeneID" id="4388338"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01312"/>
    <dbReference type="eggNOG" id="ENOG502QTDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027551_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HEP2"/>
    <dbReference type="OMA" id="RMYIYVP"/>
    <dbReference type="OrthoDB" id="2425929at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050955">
        <property type="entry name" value="Plant_Biomass_Hydrol_Est"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01840">
        <property type="entry name" value="esterase_phb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037:SF3">
        <property type="entry name" value="FERULOYL ESTERASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 9" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029039476" description="Carboxylic ester hydrolase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="11">
        <location>
            <begin position="326"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ93077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="362" mass="38140" checksum="A6DA7745ADBA03BF" modified="2006-03-21" version="1">MKFSTLASSLLALAPFSAAAEIVKRATLTRVNNFGSNPSGVRMYIYVPNNLQAKPPILTAIHYCTGTANAFYTGTPYARLADQYGFIVIYPESPNDGGCWDVSSKATLTRGGGANSNSIANMVTYTISQYKADPERVFVAGTSSGAMMTNVMAATYPDLFKAASAYAGVAAGCFYTGTVAGWNSSCANGQSIASQDAWAKTARDMYPGYTGSRPKMMIYHGSADSTIYPPNFNETMKQWSGIFGYTYGQPQQTLPNTPAAPYTKYVYGPNLVGVYGTGVTHNIAVNGAADMEWFGITGGSTTPTPTSSATPGGPTTSAPPTQPSGCTSAQWGQCGGNGYAGCKTCASPFKCTFVNDWYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HER6</accession>
    <name>Q2HER6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine peptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_01288</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220509.1">
        <property type="nucleotide sequence ID" value="XM_001220508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HER6"/>
    <dbReference type="ESTHER" id="chagb-q2her6">
        <property type="family name" value="Prolylcarboxypeptidase"/>
    </dbReference>
    <dbReference type="MEROPS" id="S28.004"/>
    <dbReference type="GeneID" id="4388349"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01288"/>
    <dbReference type="eggNOG" id="KOG2182">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023630_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HER6"/>
    <dbReference type="OMA" id="WLECNEI"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF23">
        <property type="entry name" value="SERINE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ93053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="55804" checksum="8891F97ED6B4BAE5" modified="2006-03-21" version="1">MKIPAGAVLPLAPWIAPKAALRGVQDVTSESARAVIRAAGAGSTCEWFPQPIDHKNPDLGTWQQLYCVNPQWWAPGAPVVVMTPGEMPITSAINSGFGYSYLSNTTMSGTYAETLGAAAVVVEHRYFGGSSPYDGFDSETLQYLTMEQAAEDIVNFAKNVVFPFDKEQTSVATKTPWVYWGASYAATLGSWIEHFHPGVFHAFHLSSATVEANTDNWYYYDTIRKGIDAYRNDTSCSLALTEVAAFVDSILLESPQNQTKVDALKQYFGATFPIADDDFAYTKSSVPISASVGNYAAYFRFNFRDSTCTYFDTWGQDDPLWCLNTHDLLNPFFEARTLGNPWRTWYWFLCNEPLASWATGAPPGSPSIVSRKIDSAYWQRQCEMHFPPVDGLKYGSSNGKTPDSLNLATGGWGRNSTRVIWTSGEFDPWRATGMSSEVRPGGPLESSDNVAVFVIKNAEHSDDAFTPRALANLGIKVNPDVVRVQEQSIELIKKWVSQYLVSNGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HF86</accession>
    <name>Q2HF86_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_01118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220339.1">
        <property type="nucleotide sequence ID" value="XM_001220338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HF86"/>
    <dbReference type="STRING" id="306901.Q2HF86"/>
    <dbReference type="GeneID" id="4388324"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01118"/>
    <dbReference type="eggNOG" id="ENOG502T4XY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1543790_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HF86"/>
    <dbReference type="OMA" id="CEIAQLD"/>
    <dbReference type="OrthoDB" id="3598281at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ92883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="188" mass="21165" checksum="F1A4C09282ACE6B3" modified="2006-03-21" version="1">MDLAGTIGLETAQTEPRATQPRYAIETEPFGEDEVEQYLAELLGAYRACYPEANEEGVPRSGDPDQAQNIRHTLRTLFGHHLELVDDDQFLLQEEEEDVLDAFMTLIRDKRVLLGHQGEAFASLSDCLQHLENLSHSTFVKRILLSVRTSQGSLLAAHLPARKFGGIIRWKLDEIYGIFCEIAQLDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFH5</accession>
    <name>Q2HFH5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin synthase</fullName>
            <ecNumber evidence="4">2.5.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_01029</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.9" evidence="4"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220250.1">
        <property type="nucleotide sequence ID" value="XM_001220249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFH5"/>
    <dbReference type="FunCoup" id="Q2HFH5">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HFH5"/>
    <dbReference type="GeneID" id="4387138"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01029"/>
    <dbReference type="eggNOG" id="KOG3310">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034388_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HFH5"/>
    <dbReference type="OMA" id="HFVTGHV"/>
    <dbReference type="OrthoDB" id="10258924at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000004">
        <property type="entry name" value="Riboflavin synthase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000006">
        <property type="entry name" value="Riboflavin synthase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006767">
        <property type="entry name" value="PRK09289.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098:SF0">
        <property type="entry name" value="RIBOFLAVIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="RIBOFLAVIN SYNTHASE ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lumazine-binding" evidence="10">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="9">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="9">
        <location>
            <begin position="104"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="10">
        <location>
            <begin position="104"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ92794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="233" mass="24442" checksum="268E9922815C26C9" modified="2006-03-21" version="1">MFTGIVEEIGTVTELNPSDATGGTSLTITLPPTSTLLSDCHLGDSIAINGVCLTVTTFTAQPPSFTVGIAPETLRLTNLGSLTPSSRVNLERAVRADTRMGGHFVQGHVDCTATLVGRVPDGNAVTLRLAPARREALRYVVHKGFVAVDGASLTVTRVDDEEGWWEVMLIAYTQERVVTAAKEVGETVNLEVDMTAKYVEKSLKGYLEGLGEGSGGLLKKVLEGAAAGKGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFX7</accession>
    <name>Q2HFX7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acetylserotonin methytransferase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220098.1">
        <property type="nucleotide sequence ID" value="XM_001220097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFX7"/>
    <dbReference type="STRING" id="306901.Q2HFX7"/>
    <dbReference type="GeneID" id="4387288"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00877"/>
    <dbReference type="eggNOG" id="ENOG502SETB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005933_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HFX7"/>
    <dbReference type="OMA" id="KHPPNDG"/>
    <dbReference type="OrthoDB" id="5383338at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="70157" checksum="264508605CDD2A9E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGU1</accession>
    <name>Q2HGU1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219784.1">
        <property type="nucleotide sequence ID" value="XM_001219783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGU1"/>
    <dbReference type="GeneID" id="4387126"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00563"/>
    <dbReference type="eggNOG" id="ENOG502QS87">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040551_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HGU1"/>
    <dbReference type="OMA" id="AMIAMSH"/>
    <dbReference type="OrthoDB" id="1705416at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00266">
        <property type="entry name" value="TIGR00266 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31801">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31801:SF0">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="TRAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ92328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="425" mass="44735" checksum="0FB899315173D870" modified="2006-03-21" version="1">MANYYPPPPGAGGPSAGGQQSYPPPPGSAPPTQTQFSYPAPPSSTQAATNYPPPPQAGAAPTPPPASSTPSYQHQQQHYAPPPQQQQYAPPPQQQYAAPPQQQYAPPPQASPSPMQHGALPQHLRTASTASQGSQKQPQFAAPPSYPKEDDKGAYPAEKTQHLQQAHAQAQVQAQAHSPAIDPTGAPTGNNFAGATSTIVDDVGTFNGGSYRISHRDCNSILTIQLAIGCPVEARPGSMIAMSPSIVLKGHIKFSMKKLVAGGDMNSSTFTGPGELLLAPPMLGDITSLRLSGQEAWSVSHDGFLACTQNVIKDYKRQGLGKAMFSGEGLWVYKISGTGLLWLTSFGAIIRKDLMDGEKYIVDNGHLVAWNTKYVLERVASGGLMSGMASGEGLVCKFTGPGTVFIQTRNAKSFTAYMTGQQAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH35</accession>
    <name>Q2HH35_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dihydrolipoyllysine-residue succinyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_00469</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="5"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219690.1">
        <property type="nucleotide sequence ID" value="XM_001219689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH35"/>
    <dbReference type="FunCoup" id="Q2HH35">
        <property type="interactions" value="761"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HH35"/>
    <dbReference type="GeneID" id="4388026"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00469"/>
    <dbReference type="eggNOG" id="KOG0559">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HH35"/>
    <dbReference type="OMA" id="NMPQTAV"/>
    <dbReference type="OrthoDB" id="5391403at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000006">
        <property type="entry name" value="Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004309">
        <property type="entry name" value="PRK05704.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="14">
        <location>
            <begin position="40"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="115"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ92234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="425" mass="46404" checksum="307BD4873E939BF5" modified="2006-03-21" version="1">MLYRGLRLAARTAPRLALSNTSSALRQLPVQFQHVRTYADKIVKVPTMAESISEGTLKQWNKSIGDFVEQDEEIATIETDKIDVAVNAPEAGVIKEYFANEEDTVTVGQDLARIELGGAPSGDKPTATESKESPKEATPEAQPEQDKAPEPKAQETKPTAPPVSPKEESTTTKQPSKPAKAATEGPATLGSRDERRVKMNRMRLRIAERLKQSQNTAASLTTFNEVDMSALMEFRSKYKDEVLKKTGVKLGFMSAFSRACVLAMRDIPVVNASIEGPNGGDTIVYRDYVDISVAVATEKGLVTPVVRNVESLDLIDIEKSIADMGKKARDGKLTIEDMAGGTFTISNGGVFGSLLGTPIINLPQSAVLGLHAIKDRAVAINGKAEVRPMMYIALTYDHRLLDGREATQFLVKIKEYIEDPRKMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH96</accession>
    <name>Q2HH96_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase EFM5</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM5</name>
        <name evidence="6" type="ORF">CHGG_00408</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that trimethylates elongation factor 1-alpha at 'Lys-79'.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219629.1">
        <property type="nucleotide sequence ID" value="XM_001219628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH96"/>
    <dbReference type="FunCoup" id="Q2HH96">
        <property type="interactions" value="247"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HH96"/>
    <dbReference type="GeneID" id="4387112"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00408"/>
    <dbReference type="eggNOG" id="KOG3350">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074410_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HH96"/>
    <dbReference type="OMA" id="CNFRPEH"/>
    <dbReference type="OrthoDB" id="206354at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03187">
        <property type="entry name" value="Methyltr_EFM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019369">
        <property type="entry name" value="Efm5/EEF1AKMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041370">
        <property type="entry name" value="Mlase_EEF1AKMT1/ZCCHC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200:SF0">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10237">
        <property type="entry name" value="N6-adenineMlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ92173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="258" mass="29525" checksum="72E36142E37B0FEA" modified="2006-03-21" version="1">MTNHESDDDGLSLPASTLDALKEFYAERDARAEEFKKLKVQAEAIHAAIDKVEVEVKPLSMDAFTEDWNESQFWYADETAELYAKLMLEGATSDMTVAVVSTPSVFMAVKNILNAAPPEQPKPKVVLLEHDRRFNIFPEFVYYDFAEPLKLPGTCDRIICDPPFLSEDCQTKAALTVRWLARPLSPNTDQEQPQQQQQQQPRLIVCTGERMEDVVTRVYRAFGLRTTDYEPVHARGLGNEFYCYANFESSSWGWRKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHC1</accession>
    <name>Q2HHC1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein URE2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_00383</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays an important role in the cellular response to the nitrogen source.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219604.1">
        <property type="nucleotide sequence ID" value="XM_001219603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHC1"/>
    <dbReference type="SMR" id="Q2HHC1"/>
    <dbReference type="FunCoup" id="Q2HHC1">
        <property type="interactions" value="593"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HHC1"/>
    <dbReference type="GeneID" id="4387927"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00383"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_14_2_1"/>
    <dbReference type="InParanoid" id="Q2HHC1"/>
    <dbReference type="OMA" id="IKPIQLY"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017298">
        <property type="entry name" value="Ure2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF23">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN TPCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037861">
        <property type="entry name" value="Prion_URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="95"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="183"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR037861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ92148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="319" mass="35884" checksum="207B57F92AE216F2" modified="2006-03-21" version="1">MACLHDVQILSEYIAYRGPSGTGPDVVQRSAAVKAITQLASDLHVGGLRHPASQIEDDSHGILSQLFLNYSLPNPAAVTSAQSLTKPTMGSQPNLQPIQLWGRRGPNPPKVTMILEELGLPYEHIPIEFKDVKQPEYLAINPNGRLPAIRDPNSGLTLWESGAIIEYLVERYDTDRRLSFAPGTNDAYHTRQWLYFQASGQGPYFGQATWFKMYHHEKVPSAFERFKTEVNRVSGVLEAYLESQRSAAGEGGGPWLVGGKMTFADIAFIPWYCWMDWMLDDEEFKLDDYPTVKDWLDRMRARPSVTKVLTDIKPANAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHI1</accession>
    <name>Q2HHI1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_00323</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219544.1">
        <property type="nucleotide sequence ID" value="XM_001219543.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4388210"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00323"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_4_1"/>
    <dbReference type="InParanoid" id="Q2HHI1"/>
    <dbReference type="OMA" id="IVMEREN"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="694"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1214"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1245"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1279"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1313"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="325"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="618"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1498"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="641"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1499"/>
            <end position="1508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ92088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1697" mass="187315" checksum="17FF9E8A4CE1614F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHK5</accession>
    <name>Q2HHK5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_00299</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219520.1">
        <property type="nucleotide sequence ID" value="XM_001219519.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HHK5"/>
    <dbReference type="GeneID" id="4386552"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00299"/>
    <dbReference type="eggNOG" id="ENOG502QUFK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000211_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HHK5"/>
    <dbReference type="OMA" id="DIMHTPM"/>
    <dbReference type="OrthoDB" id="3182339at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022099">
        <property type="entry name" value="DUF3638"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022105">
        <property type="entry name" value="DUF3645"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046541">
        <property type="entry name" value="DUF6606"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF33">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12340">
        <property type="entry name" value="DUF3638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12359">
        <property type="entry name" value="DUF3645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20255">
        <property type="entry name" value="DUF6606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUF6606" evidence="10">
        <location>
            <begin position="8"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3638" evidence="8">
        <location>
            <begin position="1989"/>
            <end position="2215"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3645" evidence="9">
        <location>
            <begin position="2335"/>
            <end position="2367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="746"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1787"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1792"/>
            <end position="1806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ92064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="2895" mass="326254" checksum="968FE04426E27C06" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHV7</accession>
    <name>Q2HHV7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_00197</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219418.1">
        <property type="nucleotide sequence ID" value="XM_001219417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHV7"/>
    <dbReference type="STRING" id="306901.Q2HHV7"/>
    <dbReference type="GeneID" id="4387497"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00197"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_12_1_1"/>
    <dbReference type="InParanoid" id="Q2HHV7"/>
    <dbReference type="OMA" id="LFTDFSM"/>
    <dbReference type="OrthoDB" id="2962696at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ91962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="302" mass="31004" checksum="49BF04FB738A5228" modified="2006-03-21" version="1">MASNLDAASLFRVDGMVAVVTGGGTGIGLTMARALAINGAKRVYLLGRRLDVLHTAAAEHPDIFRPIQCDVTAHASLQSAVDRVAADTGHVNLLVANSGVGGPAAGWNPALSVADVRAKLFSQASMDGMTSTLDVNVTGAFFTIVAFLELLDAGNKRALEGGFGRPIVEGGGVPAIQSQVIVTGSIAGFSRMAMSSPAYAASKAAIMHLTKQASSSLAGYGIRANALAPGLFPSELASGMIGTREPSKESADDPRFIPSRRFGGDEEMAGMLLYLASRTGAYTNGAVLLADGGRSAVMRSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI89</accession>
    <name>Q2HI89_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219286.1">
        <property type="nucleotide sequence ID" value="XM_001219285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HI89"/>
    <dbReference type="STRING" id="306901.Q2HI89"/>
    <dbReference type="GeneID" id="4386580"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00065"/>
    <dbReference type="eggNOG" id="ENOG502RE9P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007898_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HI89"/>
    <dbReference type="OMA" id="NKVPWLA"/>
    <dbReference type="OrthoDB" id="3029913at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1168" mass="130316" checksum="F394AFF6879C2E21" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HIB7</accession>
    <name>Q2HIB7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBZ4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219258.1">
        <property type="nucleotide sequence ID" value="XM_001219257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HIB7"/>
    <dbReference type="GeneID" id="4388236"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00037"/>
    <dbReference type="eggNOG" id="ENOG502SA6U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_834194_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HIB7"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019240">
        <property type="entry name" value="DUF2196"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03833">
        <property type="entry name" value="YwbE family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40069">
        <property type="entry name" value="YWBE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40069:SF1">
        <property type="entry name" value="YWBE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09962">
        <property type="entry name" value="DUF2196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="36000" checksum="1F609EA0D61F042D" modified="2006-03-21" version="1">MDTPGEPNLSPNNDAIAKQLDRVNTQFKDLQQQMTDVTNEWKQHERDRQSECCDLIRSEFRSPDSPIKKIIEASVRAELRATVKSLQKRLNPDEHACRLRQGLAACAARPTLRHLEHFSADERLGMRLLLLVQPNLFIATQNSNMARVPTTNHVTPGALVNIVLKEDQPTGRTVQGVVSQLLTKGNHPRGIKVRLSDGRVGRVQSMAGGAGSMGSQIQLDGNVEVAAEVGPAGVAPRGRVRHVADARLDQGPPPSTQPVGLDAYIKPAKKRGKGKGGTGNTAAQAAARDSQLEAAAHAGQSSPEEQESMCPVCGDFRGDEAALTHHVQSHFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM06</accession>
    <name>Q2GM06_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_11050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408038">
        <property type="protein sequence ID" value="EAQ82874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230223.1">
        <property type="nucleotide sequence ID" value="XM_001230222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GM06"/>
    <dbReference type="GeneID" id="4397381"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_11050"/>
    <dbReference type="eggNOG" id="ENOG502SSB8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035269_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GM06"/>
    <dbReference type="OMA" id="YRCTINS"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="174"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ82874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="417" mass="46772" checksum="0EE3152A5E527028" modified="2006-03-21" version="1">MSFINNGFPALVTADKHATLFAPTGNDNIAISVFYVLNWVFFGLCAVVFSVRVYIRFVCFRKLATEDYLMLVGLALHSAQTVLIQLYVGYMYDVEAVEKGDHSKISSDFFANSKKGFTALGVCVYITVVGLLVIKLNFLLFFKPLGTGFRSFHIAWWIVTVFTVGGAVVLCGLQEIRFLCFPIWILWGSGINRRKKLTLSFVFSLVWVTIAISIVRGTVFHEQYTMAVSGQVVQSQSATFTWFWFHAELSVAFLVACIVSFRSLFVQRAKRENVLRQEKQQREAAYRSAIRHGRGWRAKWQQLNGSVLDKCRTLEDWPGSDADSPHGSCHGLPTAPSGLMTVDFNDDANWKKTAGGVVHMTTETTVRKTADFYPQSRGLQCSQGPAPTGSMHSEEVLLQDPEAVHVRQNEYKIGVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMC5</accession>
    <name>Q2GMC5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_10879</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226146.1">
        <property type="nucleotide sequence ID" value="XM_001226145.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4397185"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10879"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001248_5_0_1"/>
    <dbReference type="InParanoid" id="Q2GMC5"/>
    <dbReference type="OMA" id="QYNQSMA"/>
    <dbReference type="OrthoDB" id="5095382at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF6">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="5">
        <location>
            <begin position="294"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="4">
        <location>
            <begin position="645"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="1391"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="496"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1292"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1895"/>
            <end position="1928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1294"/>
            <end position="1308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ83061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1928" mass="217436" checksum="B8E4F2D0569C24EE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMC9</accession>
    <name>Q2GMC9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytidyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226142.1">
        <property type="nucleotide sequence ID" value="XM_001226141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMC9"/>
    <dbReference type="STRING" id="306901.Q2GMC9"/>
    <dbReference type="GeneID" id="4397100"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10875"/>
    <dbReference type="eggNOG" id="KOG3351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035272_3_1_1"/>
    <dbReference type="InParanoid" id="Q2GMC9"/>
    <dbReference type="OMA" id="VEIWDPF"/>
    <dbReference type="OrthoDB" id="330671at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="1">
        <location>
            <begin position="210"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="406" mass="44326" checksum="D1680D11752A1ED3" modified="2006-03-21" version="1">MGLGDHPSLLMLPYPPNPLTRDSLSAAYRPSLKSALAKVRRPDGAAQLTVAIACPVLQGQFLRSKTLSWPDAQTLVAGTYGLISVLCAELSINTEVNGGPGSVDSTVVLIDDDRNKRYPVDFRPAIEPNNTVVVDMATFASSHFPWNLIFSVRSELGFQVSQAYLKFAEGRQNLLQSQLIPVEGGLVLNVAKSDPSAVAPQTSTYPTVCLGGTFDYLHPGHKLLLTAGALLLQVPRRGDRVPPCRYIIGITGDEMLRNKKFAEYVQTWEERARNVISFLAQLLELSPRGWKDSTSPQIEEKDGDFTATFRDGAIQVRCVRIQDAFGPTITVEDIQALVVSAETRSGGQAVNEKRAEKGWHALEVFEVDVLDAEEVSDESTKTENFASKISSTAIRQQRAARGGTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMV8</accession>
    <name>Q2GMV8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_10696</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228623.1">
        <property type="nucleotide sequence ID" value="XM_001228622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMV8"/>
    <dbReference type="GeneID" id="4396964"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10696"/>
    <dbReference type="eggNOG" id="ENOG502SJSX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_355725_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GMV8"/>
    <dbReference type="OrthoDB" id="3642468at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="702"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="745"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="54"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ84292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="782" mass="88109" checksum="11D686D604BD54B8" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNT8</accession>
    <name>Q2GNT8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_10366</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228293.1">
        <property type="nucleotide sequence ID" value="XM_001228292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNT8"/>
    <dbReference type="GeneID" id="4396843"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10366"/>
    <dbReference type="eggNOG" id="KOG4505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008635_5_1_1"/>
    <dbReference type="InParanoid" id="Q2GNT8"/>
    <dbReference type="OMA" id="QSETRND"/>
    <dbReference type="OrthoDB" id="5327978at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF1">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208841" description="Cation/H+ exchanger transmembrane domain-containing protein" evidence="7">
        <location>
            <begin position="19"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="8">
        <location>
            <begin position="2"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="346"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ83962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="409" mass="44464" checksum="DE587D39BD3D46C6" modified="2006-03-21" version="1">MAAMWMATSLLVWALVPGIPLLHALAIGSCVTPTDPVLSAVIVKGKFADHNVPKDLQKIIIAESGANDGLGYPFLFFALYLIKYIGDGATPGDGGARVAMGMWFGETWGYTILLSVAYGAAVGWVAKELLHWAEERKFVDRESFLVFAISLALFIVGTCGMIGSDDVLACFVAGNVFTWDDWFRLETLDDSLQPTIDMLLNVSIFMWYGAVCPWDLFLHNEVVPIGRLIALGVLVLLFRRLPWVFAIHKFIPQIEEVRQAIFVGFFGPVGVSAIFYLYVTLEFLHTLDVDGDARADVKALPEAVTVVVWFIAICSIQPGGESGDEAGEGSRRSVFRIGGSIIPRRQEARGDVAPGRNEIPDSNKNSSTDAVGSGQETVVESSVQYISRTVRFPDEPPTTVAQVAGPSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GP73</accession>
    <name>Q2GP73_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytokinesis regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228158.1">
        <property type="nucleotide sequence ID" value="XM_001228157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GP73"/>
    <dbReference type="STRING" id="306901.Q2GP73"/>
    <dbReference type="GeneID" id="4396606"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10231"/>
    <dbReference type="eggNOG" id="ENOG502QX1K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008906_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GP73"/>
    <dbReference type="OMA" id="DWGEGSL"/>
    <dbReference type="OrthoDB" id="19159at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990334">
        <property type="term" value="C:Bfa1-Bub2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034586">
        <property type="entry name" value="Bfa1/Byr4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140:SF1">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="786"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="482"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="997" mass="110535" checksum="2E6BE34CBB4AF18B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPD0</accession>
    <name>Q2GPD0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen54 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_10174</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN54 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228101.1">
        <property type="nucleotide sequence ID" value="XM_001228100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPD0"/>
    <dbReference type="STRING" id="306901.Q2GPD0"/>
    <dbReference type="GeneID" id="4396566"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10174"/>
    <dbReference type="eggNOG" id="KOG4772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028449_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPD0"/>
    <dbReference type="OMA" id="MYMRLRH"/>
    <dbReference type="OrthoDB" id="408683at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024337">
        <property type="entry name" value="tRNA_splic_suSen54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024336">
        <property type="entry name" value="tRNA_splic_suSen54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12928">
        <property type="entry name" value="tRNA_int_end_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen54 N-terminal" evidence="4">
        <location>
            <begin position="102"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ83770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="403" mass="43878" checksum="205A2756C0C396B7" modified="2006-03-21" version="1">MPLDDDDNPALAPPAPYLSSALPADTATAAAPAATDDLTTEDLIEDEGAASQDFRAFAAALQFRKTAGVSAQTIRRGEKDFEAHGTRAQADALEQSRGAMRDVLSYTRVHAAGRGGNLARGWYFPGWWEGYREEEVEEGKEGEKKPFGFVRERVVVLEGSSVASQALGRAVTGQAKDRPARGRDWLLPEEALYLVERGSLDLWWPLKGLEELFPPDGTAEAVKEDGEEDDEDDEVDEYDVGFPLSLQAAYALLIGEDGERGKISLQKFQVYSNLKRCGYNILRAPPTVNHPTTKPATTTPLAMVRLTPHRDPPPSSLRPKWTKLRHPPPDFQLAVVDAQASSVPTGAEITALLGATPPAPGKPEWTGPGRIYARLKHGYRNVLVAVVDHGVINYMRFAEGGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQC4</accession>
    <name>Q2GQC4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_09830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227757.1">
        <property type="nucleotide sequence ID" value="XM_001227756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQC4"/>
    <dbReference type="STRING" id="306901.Q2GQC4"/>
    <dbReference type="GeneID" id="4396817"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09830"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GQC4"/>
    <dbReference type="OMA" id="LLLTYWK"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF22">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208490" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="17"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="64"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ83426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="507" mass="53673" checksum="C0B0C38807BA663F" modified="2006-03-21" version="1">MGLATLFLTLLARVLSFHPLLILMASTDGAVQALQAAFPGGQVHIRGSDKYDKLNGAYLSGLESDLKPLLFFQPSSVTEVAAFVSTIRPFAGLLDCAIRGAGQQPLPGCANVDNGITLDLGLLDDITLTQDNSVVQIGAGARWGAVYQKLDALGLSVTGSRSAMGGVGGLALAGGLSFFSSREGFICDNVVNFQVVLSSGKVINANANENSDLWVALRGGGNNFGVVTRFDFRTFKQGLLWGGNVFYFADKFPGQIESLVNELKKPNASDQTHIMISIGHSGAMATAFGAPIMCLNQAYYNEPVENPPVLDPFTKMTPQIDVLNSMSLKNVTAAASEQTAAAQSQVRAAYINIAVKADVATLQAISDIYTAALPPLYGVSGATLSLTLQPFPVSLLAKSDALGGNVLGLHADDGPIVSVLLLSYWEKRSDDAAVIAFMERTLAQMRADATAKGTIIPYIYMNYAFTGQDVINSYGPANKAKLQAASKKYDPIGLFQKAFPGGFKLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQN1</accession>
    <name>Q2GQN1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CHGG_09723</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227650.1">
        <property type="nucleotide sequence ID" value="XM_001227649.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GQN1"/>
    <dbReference type="GeneID" id="4396969"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09723"/>
    <dbReference type="eggNOG" id="KOG2518">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2885">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_259048_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQN1"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
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        </source>
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    <sequence length="1331" mass="149069" checksum="084FED8733077599" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
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    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ85548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1089" mass="119741" checksum="D2A9F63887DD821D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GR83</accession>
    <name>Q2GR83_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_09521</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227448.1">
        <property type="nucleotide sequence ID" value="XM_001227447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GR83"/>
    <dbReference type="STRING" id="306901.Q2GR83"/>
    <dbReference type="GeneID" id="4395395"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09521"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="InParanoid" id="Q2GR83"/>
    <dbReference type="OMA" id="TAFIWQI"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ85507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="343" mass="36988" checksum="FEC03A1155D3A6E3" modified="2006-03-21" version="1">MSTKGTVLVTGANGYIAARTVEAFLKAGYSVKGTVRSLSSATEVKQAVTEYADKLEFIEVPDITVAGAFDSAVKGVDAIAHLASPVSFDFTDPEPVLHSAINGTVRILESALKESNIKNFVLMSSVTAILEPKTEDYTFTEADWNTAAENAVAELGKATPGRVIYAASKVAAEKAMWKFRDQKKPKFTLTAINPCFVAGPPLVVPASADKISMSNLLIPQVFTGKALEEAGFPGSDGYVDIRDVARLVVFGVEHGSETNNQRFLAAAHYSPAQAVADILREEFPERAEIIKQGTPGEGYFPDYRFPARSAFDGTKAVRATGQDYIPWRQTVLDTVEKLKSILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRI4</accession>
    <name>Q2GRI4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_09420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227347.1">
        <property type="nucleotide sequence ID" value="XM_001227346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRI4"/>
    <dbReference type="FunCoup" id="Q2GRI4">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="GeneID" id="4394795"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09420"/>
    <dbReference type="eggNOG" id="ENOG502SMPB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004835_3_1_1"/>
    <dbReference type="InParanoid" id="Q2GRI4"/>
    <dbReference type="OMA" id="RHIIYRP"/>
    <dbReference type="OrthoDB" id="4685598at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ85406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="561" mass="62529" checksum="F1D1F09D7216B423" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRM0</accession>
    <name>Q2GRM0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_09384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227311.1">
        <property type="nucleotide sequence ID" value="XM_001227310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRM0"/>
    <dbReference type="GeneID" id="4395362"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09384"/>
    <dbReference type="eggNOG" id="ENOG502T6FW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_569859_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRM0"/>
    <dbReference type="OrthoDB" id="4839021at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ85370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="479" mass="52957" checksum="CDD53CB07ABD25B1" modified="2006-03-21" version="1">MPKEVQTKQALHLEVIHFAPGQMFSSRLLAERVFGLLLGPQYSEPTGSNQLAQIRERASVILSRIFDLCLARAATFAALDDWDLGWQIVAGDLAENYKCVMGAGELKELVTLFADARVRFLDSPRANRPHASPDKLANLIDRWLEATLHDAAAISPHPPASPSLLPARPAPLENLFAGFSLHTHGASPAAATAAGPTATDWPPSHLPAADRHLLDHFKVRAQLAGVCWDTKGEMPNLPDDKSPPLALRLFLGWLAAAHTPPPAATTTPTTAPPFALFAAPVAFADNRERQAWFRPSGCQSKLFGHVEGFLAYAADNFAAGKTMVLGLLTPVLRRFGAALMLRLVERGGVRGVQVVFFCPWDEHPWIKEQWRLQDWRLRLWKSAVLDAVDAWAAKHGVVIHEGYSSGSIRVPRDRDHDSVGMCAGWLLRVVTATQKTIPGDGEDEEWEWEETCHFRKLENWAKVEEDIEEDEKMEVDAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GS09</accession>
    <name>Q2GS09_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">General negative regulator of transcription subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CHGG_09245</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227172.1">
        <property type="nucleotide sequence ID" value="XM_001227171.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GS09"/>
    <dbReference type="GeneID" id="4395580"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09245"/>
    <dbReference type="eggNOG" id="KOG0351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_227275_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GS09"/>
    <dbReference type="OrthoDB" id="1923159at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GeneID" id="4395221"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09162"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OMA" id="WHEGCEM"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
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            <end position="316"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01734"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ85148.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="517" mass="57887" checksum="630ADEFEBB383C6E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSB6</accession>
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        </submittedName>
    </protein>
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        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
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        <lineage>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
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            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ85124.1"/>
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    </dbReference>
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    <dbReference type="STRING" id="306901.Q2GSB6"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09138"/>
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    <dbReference type="OrthoDB" id="3166386at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
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        <location>
            <begin position="218"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ85124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="581" mass="64575" checksum="6201A53FE7C65EC3" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSR5</accession>
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        </submittedName>
    </protein>
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        <lineage>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="113" mass="12837" checksum="C7B5B22307C5416D" modified="2006-03-21" version="1">MCKGAYLLCRIWRAHGIKIASWSRDRWRQNQPRSLTMLRPDYALDCPVAIAITDCSSFYARDGYQGRDTKAARRALPSSTEQEEVGDETFFVEDYLSGSGLAVSVPPDCVWQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GT92</accession>
    <name>Q2GT92_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001226738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GT92"/>
    <dbReference type="STRING" id="306901.Q2GT92"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08812"/>
    <dbReference type="eggNOG" id="ENOG502SI3B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029043_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GT92"/>
    <dbReference type="OrthoDB" id="5412502at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="292" mass="31875" checksum="9AC05BE077396405" modified="2006-03-21" version="1">MAPLANTTDNSGWFPPGAEPSEGWHVDAVTLALLAIIGDARSEDLTRAMTATRLAILPRLVPAMQLLSAVRPARLPRANATLAAIHGPIPDEVFRKKTIGYFVNVLHGMDDMQRLGFRVLEVKHNTQKKNQDLESANVKFASVPPSRLVRGVLIFSSALTLGLFIAAIAWQNGPAALAVAFMGISSSLMSHASSWRPGLRYGALMATGSVSLMLSILMLGNCSWRARVSIALSYIVLNLLYWIVSMLPRRLFWDMSRYIVNDVTPSDALSAHEDTVPNPTSPDERKSSTRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTN3</accession>
    <name>Q2GTN3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226598.1">
        <property type="nucleotide sequence ID" value="XM_001226597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTN3"/>
    <dbReference type="STRING" id="306901.Q2GTN3"/>
    <dbReference type="GeneID" id="4395462"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08671"/>
    <dbReference type="eggNOG" id="ENOG502RASA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073405_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTN3"/>
    <dbReference type="OMA" id="HRHLKDW"/>
    <dbReference type="OrthoDB" id="3445164at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="32612" checksum="78E4F5C2F85B88B2" modified="2006-03-21" version="1">MIEVLYSGTPSMEGSRSPFTREEHRTNQTSLPKGGKRAPRRSQTQHEYFPPQSPGFTLYTIPQPPPIPESKPQTPSEPSQEPAQKAVEQTRPPARRPPLGPPRRSYSVTDQQPIPRRHKPTVRLALTDLPPELHFVMFEFLDPIDSTCFGLTNKHFYAIHRRLHGTVSLTARRNGPNELEWAWHLAGNVVSPSSFVAVGSKDALSKLRVRGQGYCRMCGVTKCQLHKHIQEWMGEGREYCSVTQKYGPVAPEGSKSYCYMSKPGDKRRHLSALWCSKVDDAAPALWVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTN4</accession>
    <name>Q2GTN4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226597.1">
        <property type="nucleotide sequence ID" value="XM_001226596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTN4"/>
    <dbReference type="STRING" id="306901.Q2GTN4"/>
    <dbReference type="GeneID" id="4395461"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08670"/>
    <dbReference type="eggNOG" id="ENOG502SQGV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1320763_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTN4"/>
    <dbReference type="OrthoDB" id="10059120at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="208" mass="22442" checksum="F40D8DA51F163B9A" modified="2006-03-21" version="1">MLKAVMAEATPQGATVPAYKFAINSTIVQHVVPTSQLNKPTTQSTEEGTSKKGQAGRRGMHSATGGYWNEKTDGMWSFKWDGDAKGLDVVLMPRERSSNALVTQGWGPYPAMCPGAEQLERKGAVEPHHTLSQPCVSPDSAHATPPDQSGRPPFVTYLATAARVRVGVLRRPHGPVGLVAWTSWAVNPAVAQQITLRRATISCHRSHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUC6</accession>
    <name>Q2GUC6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_08428</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226355.1">
        <property type="nucleotide sequence ID" value="XM_001226354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUC6"/>
    <dbReference type="FunCoup" id="Q2GUC6">
        <property type="interactions" value="869"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GUC6"/>
    <dbReference type="GeneID" id="4394676"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08428"/>
    <dbReference type="eggNOG" id="KOG1696">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083919_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUC6"/>
    <dbReference type="OMA" id="NRVWIDP"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01417">
        <property type="entry name" value="Ribosomal_L19e_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.240:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1650.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_eL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023638">
        <property type="entry name" value="Ribosomal_eL19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033935">
        <property type="entry name" value="Ribosomal_eL19_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006343">
        <property type="entry name" value="PRK08570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00526">
        <property type="entry name" value="RIBOSOMAL_L19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="6">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ84414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="193" mass="22487" checksum="CAFFB95853F1FC3D" modified="2006-03-21" version="1">MVNLTTQKRLASSVLGCGQRKIWLDPNEVSEISNANSRQTIRKLVSDGLIIKKPVTMHSRSRARELNLARRIGRHRGFGKRKGTADARMPEQVLWMRRQRVLRRLLVKYRASGKIDKHLYHELYHLAKGNTFKHKRALVEHIHRAKAEKARENQIKEEMDAKRARTKAARERKLERQAAKRNALMGEAEEESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUJ3</accession>
    <name>Q2GUJ3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_08361</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226288.1">
        <property type="nucleotide sequence ID" value="XM_001226287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUJ3"/>
    <dbReference type="GeneID" id="4394770"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08361"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_14_0_1"/>
    <dbReference type="InParanoid" id="Q2GUJ3"/>
    <dbReference type="OMA" id="CLCSQND"/>
    <dbReference type="OrthoDB" id="2690153at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF8">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21274">
        <property type="entry name" value="Rng_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="8"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ84347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="595" mass="66881" checksum="375C4FA3862A517F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUN1</accession>
    <name>Q2GUN1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cellobiose dehydrogenase-like cytochrome domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ87070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225979.1">
        <property type="nucleotide sequence ID" value="XM_001225978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUN1"/>
    <dbReference type="STRING" id="306901.Q2GUN1"/>
    <dbReference type="GeneID" id="4393918"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08323"/>
    <dbReference type="eggNOG" id="ENOG502SYC2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081649_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GUN1"/>
    <dbReference type="OMA" id="HWTLNAL"/>
    <dbReference type="OrthoDB" id="413885at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF5">
        <property type="entry name" value="CELLOBIOSE DEHYDROGENASE CYTOCHROME DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208647" description="Cellobiose dehydrogenase-like cytochrome domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Cellobiose dehydrogenase-like cytochrome" evidence="2">
        <location>
            <begin position="33"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="197" mass="20536" checksum="03D0D15277055655" modified="2006-03-21" version="1">MGPLHLAATALALGNIGLGNPVPQSTAISAAKYCDAATTICYSEWLSPEKIAYRIAIPDTATAGNFDVLLQIEAPRTIGWAAIAWGGVMVNNPLTVGWANGDKTVVSSRSASSTANTTHWTLTVLAKGVSSWGSTNLNPAGTVSLAYAQSATPPAEPANNATRFSIHNSRGKWTHDLKSAQIANFAELIEKAYAAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUP4</accession>
    <name>Q2GUP4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ87057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225966.1">
        <property type="nucleotide sequence ID" value="XM_001225965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUP4"/>
    <dbReference type="GeneID" id="4394154"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08310"/>
    <dbReference type="HOGENOM" id="CLU_2170778_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUP4"/>
    <dbReference type="OrthoDB" id="10335853at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="110" mass="11294" checksum="F695E6E95C46621C" modified="2006-03-21" version="1">MDGDDPVEPSAGRSGAPATSNCRCYGTSSKVFCHLGIISTIGVERAPAVIGQPPAAAVTIAGVPNASPAAKPDQVTYMQRIGAEPARCSWQLTARGVERGEGVVVRCQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV08</accession>
    <name>Q2GV08_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">OMP decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Uridine 5'-monophosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_08196</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OMP decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="3"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225852.1">
        <property type="nucleotide sequence ID" value="XM_001225851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV08"/>
    <dbReference type="FunCoup" id="Q2GV08">
        <property type="interactions" value="997"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GV08"/>
    <dbReference type="GeneID" id="4393396"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08196"/>
    <dbReference type="eggNOG" id="KOG1377">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030821_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GV08"/>
    <dbReference type="OMA" id="CLIKTHI"/>
    <dbReference type="OrthoDB" id="10263753at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119:SF2">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="13">
        <location>
            <begin position="37"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="165"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="203"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="10">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="10">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="10">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ86943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="403" mass="44666" checksum="1FDC24DDEB2DC4E8" modified="2006-03-21" version="1">MATRHATLGQPFAERAKTASHPLTRYLFRLMDLKASNLCLSADVTTARELLTLADKVGPSIVVLKTHYDLISGWDYNPQTGTGAKLAALARKHGFLIFEDRKFVDIGKTVQMQYTAGTARIVEWAHITNANIDAGKDMVRAMAEAAAKWKERIHYEVKTSVTVGTPLSDQFDDAEEQEQQQQQQQQQQQQQQQHQAQGQEQAQTRDDKGEPRRLEAMEQHQKRDSRDVDGRKGSIVSITTVTQSFEPADSPRLPKTNEHGDDAVFPGIEEAPVDRGLLLLAQMSSKGCLMTKDYTQACVEAARDHKGFVMGFVSQEALNAAPDDNFDPHDPRLQAARRRAAEENGQVESDGFGQQYNTPSKLVGVCGTDIVIVGRGIISAGDPPSEPERYRRKAWKASLARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVM7</accession>
    <name>Q2GVM7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225633.1">
        <property type="nucleotide sequence ID" value="XM_001225632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVM7"/>
    <dbReference type="STRING" id="306901.Q2GVM7"/>
    <dbReference type="GeneID" id="4393545"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07977"/>
    <dbReference type="HOGENOM" id="CLU_933836_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GVM7"/>
    <dbReference type="OrthoDB" id="1638493at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="298" mass="33937" checksum="3B5D779BE0EF18EF" modified="2006-03-21" version="1">MSPAEAIQQDAASQPSAASPILLDSLPVETLIEIISYTDFDTFDSIRATSQRLRSITDLHWYRILPGIIERDFHPVQEFFETVFDADVPSGMTCARLLMVSDTLDDGLHPLLGFCRVVRRWEAEFPRLRFASMPILRGFSMAMRRARWRIVGDARRAFMRQFSSARLHEAYDMWFVKPSAGECALRLMPLWDLNCSLTMSFTYLSIGTVVDEMTWPRIEESLATFGEATMHVFRERGLPHLGPFSQGLFPEPHGGILDYKHPLLEMWRAVHDGDAGVGDANYPGLSRITRRGRLEPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVP7</accession>
    <name>Q2GVP7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CHGG_07957</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225613.1">
        <property type="nucleotide sequence ID" value="XM_001225612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVP7"/>
    <dbReference type="STRING" id="306901.Q2GVP7"/>
    <dbReference type="GeneID" id="4394244"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07957"/>
    <dbReference type="eggNOG" id="ENOG502SG7I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138063_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GVP7"/>
    <dbReference type="OMA" id="NAMPERP"/>
    <dbReference type="OrthoDB" id="3230169at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013963">
        <property type="entry name" value="DASH_Dad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08654">
        <property type="entry name" value="DASH_Dad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAQ86704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="118" mass="12481" checksum="C2841C8C5FA6FA6D" modified="2006-03-21" version="1">MSGFPSRPLASHMRQPSLSANVGGQSPALVARVNEKKAELENLKELRHLSAEVATQMEALEQKLATLSDGTEAKLPKPAADAVDRDETPLPQTLVRIPTEHAPALQAHAEGAAEEASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVY1</accession>
    <name>Q2GVY1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_07873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225529.1">
        <property type="nucleotide sequence ID" value="XM_001225528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVY1"/>
    <dbReference type="GeneID" id="4393451"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07873"/>
    <dbReference type="HOGENOM" id="CLU_3106178_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GVY1"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ86620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="51" mass="5275" checksum="E3B0D8256FD21151" modified="2006-03-21" version="1">MPGVFGISGTASSLQEVHWRSCILDSEADGGGPTVWIGIAERGIGKNWSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GW02</accession>
    <name>Q2GW02_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_07852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225508.1">
        <property type="nucleotide sequence ID" value="XM_001225507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GW02"/>
    <dbReference type="GeneID" id="4393703"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07852"/>
    <dbReference type="HOGENOM" id="CLU_2941525_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GW02"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ86599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="60" mass="6636" checksum="D26BF6AFC1258B88" modified="2006-03-21" version="1">MGRARESIIWSKNDVPTRTSWSEEGSVCSEVEASVEEEEAPPTWTFRLGLAHQSDKSGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWC4</accession>
    <name>Q2GWC4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import receptor subunit TOM40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_07730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225386.1">
        <property type="nucleotide sequence ID" value="XM_001225385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWC4"/>
    <dbReference type="FunCoup" id="Q2GWC4">
        <property type="interactions" value="733"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GWC4"/>
    <dbReference type="GeneID" id="4393362"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07730"/>
    <dbReference type="eggNOG" id="KOG3296">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042174_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWC4"/>
    <dbReference type="OMA" id="TRFNYRW"/>
    <dbReference type="OrthoDB" id="19656at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ86477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="34582" checksum="FAEA70A3E8AC1756" modified="2006-03-21" version="1">MASTSDAPLAFLRKNPVFSGLSDVYNAFQERRERLGLSNPGMVENIAKEVQRDVLTTNLMFSGLRADLTKAFSFNPLFQVSHQFAMGERLSPYTFAALYGTSKIAPGGTGQDMAQFENEYLGNDFTATLKALNPSCLEGGLTGIFIGQYLQSVTPKLALGLEAVWQRAGLTQGPDTAISYVARYKADNFIASAQLQAQGALNASYWQRLSEKVQAGVDMTLSVAPSGAMMGGLAKEGITTFGAKYDFRMSTFRAQIDTAGKLSCLLEKRVAAPVMMTFAADVDHFTQQAKIGVGISIEAGGEELQEQQDALAAQPPPNIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWE6</accession>
    <name>Q2GWE6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mRNA export factor GLE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleoporin GLE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_07708</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225364.1">
        <property type="nucleotide sequence ID" value="XM_001225363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWE6"/>
    <dbReference type="STRING" id="306901.Q2GWE6"/>
    <dbReference type="GeneID" id="4393251"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07708"/>
    <dbReference type="eggNOG" id="KOG2412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018821_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWE6"/>
    <dbReference type="OMA" id="ILWAKYR"/>
    <dbReference type="OrthoDB" id="420884at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.510">
        <property type="entry name" value="GLE1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012476">
        <property type="entry name" value="GLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038506">
        <property type="entry name" value="GLE1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960">
        <property type="entry name" value="GLE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960:SF0">
        <property type="entry name" value="MRNA EXPORT FACTOR GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07817">
        <property type="entry name" value="GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="131"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="42"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="184"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ86455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="506" mass="55820" checksum="39721197A01AA17A" modified="2006-03-21" version="1">MAGSSPPRRQSYYLAAGSPQRNVLEEILGDDRNSEARHRYLLETAKREHDRVREEAERVYREQLQREERQRLLDARRKEEERIKLEEALAADRARLNELKAKKIAIPAPLPDPEPPVIVAPAVNGKVPAVPPPINNAPAQTNGTTSQKPTTIPAVPKLPSAPVPAQTQSQTPATAPHKAPEPSKTVNSVLGINGLLNNTPQPNGAASNPETSRSAAQPPTQTRPDKYVEIHKNLKMLRKSMADQAKSNPALKGRMGDMRREILQSELMDPSRFVLEPRNPAEGAAHNDATLPSIFLYLINIFAKAAIAQFINEAGARPETADPVGVCVAATLSEPDFLWRGSSLIDIMLAKFRIVCPVLFGYRGSEKTEQGRQRLGWWKDGGQWVPEQQHMDRMTGLGAGFASISLRNFAMSKKTNPFPPRVYWTAMARIVNTPHAEISDTQCVVLKAMVENYEQKFIEFYGTAAIAALRTALVDFPSRVPQKSAAVNSLEVLAQMLKRNTGLVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX03</accession>
    <name>Q2GX03_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_07501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225157.1">
        <property type="nucleotide sequence ID" value="XM_001225156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX03"/>
    <dbReference type="GeneID" id="4394409"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07501"/>
    <dbReference type="eggNOG" id="ENOG502RCZR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065853_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GX03"/>
    <dbReference type="OMA" id="IYHDTKD"/>
    <dbReference type="OrthoDB" id="2101473at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007396">
        <property type="entry name" value="TR_PAI2-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802:SF1">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04299">
        <property type="entry name" value="FMN_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010372">
        <property type="entry name" value="PaiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ86248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="28194" checksum="DF62B38047F83351" modified="2006-03-21" version="1">MYFRSAHVETDISELRRFIRENPLGILITTLPSPNYPTLQCTHIPWVLDVLDEDSNTELGTLRGHLAKQNPHCKAMQEAVERESGTVANGTLQQEVLVVFTGPVQSYVTTKFYTETKPTTGKVAPTWNYSAVQVYGRATVFFDTKAESTAAFLDKQLVDLSEHTERNIMGYTGVDGRPAPWEITDAPSSFINILKKAITGVEITIDRLEGKHKMSQELSVGDREGVIQGFEALGTDDGRRMAAAVRERSAMKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXH4</accession>
    <name>Q2GXH4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homoaconitate hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_07330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224986.1">
        <property type="nucleotide sequence ID" value="XM_001224985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXH4"/>
    <dbReference type="STRING" id="306901.Q2GXH4"/>
    <dbReference type="GeneID" id="4394037"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07330"/>
    <dbReference type="eggNOG" id="KOG0453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_3_1_1"/>
    <dbReference type="InParanoid" id="Q2GXH4"/>
    <dbReference type="OMA" id="ICATDRT"/>
    <dbReference type="OrthoDB" id="10262323at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170034">
        <property type="term" value="P:L-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170038">
        <property type="term" value="P:proteinogenic amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="6">
        <location>
            <begin position="131"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="6">
        <location>
            <begin position="216"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="6">
        <location>
            <begin position="301"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="7">
        <location>
            <begin position="467"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="424"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ86077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="605" mass="64045" checksum="71651F5C9BED2C93" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GY26</accession>
    <name>Q2GY26_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224784.1">
        <property type="nucleotide sequence ID" value="XM_001224783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GY26"/>
    <dbReference type="FunCoup" id="Q2GY26">
        <property type="interactions" value="605"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GY26"/>
    <dbReference type="GeneID" id="4393709"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07128"/>
    <dbReference type="eggNOG" id="KOG0806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GY26"/>
    <dbReference type="OMA" id="RQIPIYK"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050152">
        <property type="term" value="F:omega-amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043605">
        <property type="term" value="P:amide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF30">
        <property type="entry name" value="OMEGA-AMIDASE NIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="268" mass="28867" checksum="B2373D1C39CCD6DE" modified="2006-03-21" version="1">MASSSSTTHPPVLKQPVKLACVQLASGSDKAANLAHAAVKVREAAQTGAKIVVLPECFNSPYGCDYFPSYAETLLPSPPTPAQSPSYHALSTMARENAIYLIGGSIPELATSASEPSQNTYYNTSLTFSPSGALLATHRKIHLFDIDIPGGDHLPRIRRALPRQPADHGRPARLATIAARRGCFALVYPGAFNLTTGPLHWELLARARAVDNQLLVADPMAKVLAEAGEGEGIVVVELDGERIELARRGIPLRDQRRFDVYPDVSRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GY29</accession>
    <name>Q2GY29_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Guanine nucleotide-binding protein alpha-2 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_07125</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224781.1">
        <property type="nucleotide sequence ID" value="XM_001224780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GY29"/>
    <dbReference type="FunCoup" id="Q2GY29">
        <property type="interactions" value="418"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GY29"/>
    <dbReference type="GeneID" id="4393440"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07125"/>
    <dbReference type="eggNOG" id="KOG0082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014184_6_0_1"/>
    <dbReference type="InParanoid" id="Q2GY29"/>
    <dbReference type="OMA" id="INYGHPD"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090726">
        <property type="term" value="C:cortical dynamic polarity patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180040">
        <property type="term" value="P:negative regulation of pheromone response MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000009">
        <property type="entry name" value="Guanine nucleotide-binding protein G(O) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000051">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
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    <proteinExistence type="inferred from homology"/>
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            <end position="49"/>
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            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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            <end position="182"/>
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            <end position="205"/>
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            <end position="273"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="355" mass="41189" checksum="5469238BC11730E1" modified="2006-03-21" version="1">MCFGGREKTDESGAARSRELDKIIRADEKRMSKEVKLLLLGAGESGKSTVLKQMKLIYAQGFSKTEKMEWKPVVFTNILQSFRLIFDAMNDAGITFENPENEKNMAQMMVDYEMTAHEPLPEEYLEPVKKLWVDAGIKKAMEKGNEYALHDNLDYFCDDVERIWDKNYVPTDQDLLRSRLRTTGITETVFDLGQLTYRMFDVGGQRSERKKWIHCFENVNSLMFLVAISGYDQCLVEDKDGNQMNEALMLWESIANSHWFAKSALILFLNKMDLFKEKLVKSPITDHGFTDYHGPPNDWDQASQYFMDKFRALNRNPDKEIYGHFTNATDTNLLKITMSSVQDMIIQRNLKQLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GY48</accession>
    <name>Q2GY48_CHAGB</name>
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        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="9" type="ORF">CHGG_07106</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomium</taxon>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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        <location>
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            <end position="386"/>
        </location>
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        <location>
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        </location>
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        <location>
            <begin position="1012"/>
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        </location>
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        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
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        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
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        <location>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="912"/>
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        </location>
    </feature>
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        <location>
            <begin position="923"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1012"/>
            <end position="1024"/>
        </location>
    </feature>
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        <location>
            <begin position="1029"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1045"/>
            <end position="1060"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ85853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1129" mass="125892" checksum="DA4CC3EC04F9BE75" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GY64</accession>
    <name>Q2GY64_CHAGB</name>
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        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">CHGG_07090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="4393879"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07090"/>
    <dbReference type="eggNOG" id="KOG3178">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_5_2_1"/>
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    <dbReference type="OrthoDB" id="1535081at2759"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COMT-like"/>
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        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF11">
        <property type="entry name" value="O-METHYLTRANSFERASE (AFU_ORTHOLOGUE AFUA_2G17820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="118"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="372"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ85837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="483" mass="54326" checksum="BC139E4D957320B0" modified="2006-03-21" version="1">MPALAWGWEPSGRVLEGSSARWDFVPSSTNGMRDKTSLDKVATRKANGSIPWLNTLEALIMEDTSSALRAAEELVEALKSQPQANHAQHLALLERVDKVRTLLETPYDVIERQQETMCTSGVMYTLISTGAIKKIPDEGTITAEKLAAEMNMDVSAIHRLMRVAVVSGFFVETAPNTYAHNALSQAYQLHAQGPFFVLCMEFNKMCMALPNYFKTHKPEDIYDLKKSPYCFSIGKEGKTYYEAIDEDPEQRLIWNSCLQIIEKNMPITGMFPWESLKENVEKEPERPFVVDVAGGRGQALLKLQEEIPGAYGGKLILQDLPIVINSLKPEELPNIEAMSYDIFTPQPVKSEPPSPTPPSPTTAIFLWKFSSTNLSQDAHVYFMRRLLHDFYPSVCLDILKSTVSAMGPDSRLIVCDMLVPELVQPGRMKELYWLDLNLMSISGKEKTLHEFQQMFDAVGLELVKVWPSEIGATVQLETRLKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYA4</accession>
    <name>Q2GYA4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224706.1">
        <property type="nucleotide sequence ID" value="XM_001224705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYA4"/>
    <dbReference type="STRING" id="306901.Q2GYA4"/>
    <dbReference type="GeneID" id="4394643"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07050"/>
    <dbReference type="eggNOG" id="ENOG502RPXI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_333749_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYA4"/>
    <dbReference type="OMA" id="FSEEWER"/>
    <dbReference type="OrthoDB" id="4586356at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="813"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="572"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="621"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="836"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="861"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="904" mass="96320" checksum="D8DD6F163C62E292" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYZ6</accession>
    <name>Q2GYZ6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224464.1">
        <property type="nucleotide sequence ID" value="XM_001224463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYZ6"/>
    <dbReference type="GeneID" id="4392772"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05250"/>
    <dbReference type="eggNOG" id="ENOG502S2W1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040908_3_2_1"/>
    <dbReference type="InParanoid" id="Q2GYZ6"/>
    <dbReference type="OMA" id="WYDNFAG"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000207">
        <property type="entry name" value="Glycoside hydrolase family 128 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208594" description="Asl1-like glycosyl hydrolase catalytic domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="2">
        <location>
            <begin position="31"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="326" mass="35845" checksum="1FE3827B099D660D" modified="2006-03-21" version="1">MLLSTATFAVLLAAAPSFILPVSAASSKRGLVFTPNETSRADDKIWVEKPTSLTWYYNYESRPEPTYNDVSQSDFEFVPMMWGAPESIDDTSFLLSVQSLVKDQGINITNVLSFNEPDGPFVYGGSNMEPSAAAQIWVNNMIPIQKMGIRVGLPACTGGSSGLPWLQNFLSECSKLVSTEKNQQNCTYDFVTLHWYGNFEGLASHIGQYSAAFPNKTMWITEYNINDQDLETTQEFYNMSAEYFDRLEYVERYSLFGAFRSDVSNVGPNGAMLSANGSLTDIGAWYLGREATGILPGSSSSAFRPVLPQMSFAALAALVAVTVLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZB3</accession>
    <name>Q2GZB3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_05133</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224347.1">
        <property type="nucleotide sequence ID" value="XM_001224346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZB3"/>
    <dbReference type="GeneID" id="4391726"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05133"/>
    <dbReference type="eggNOG" id="ENOG502SMMJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_372978_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZB3"/>
    <dbReference type="OrthoDB" id="4337792at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="207"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="282"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="361"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ88514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="745" mass="79456" checksum="4EFC43150ECFEB00" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H052</accession>
    <name>Q2H052_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_04844</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224058.1">
        <property type="nucleotide sequence ID" value="XM_001224057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H052"/>
    <dbReference type="GeneID" id="4391875"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04844"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008721_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H052"/>
    <dbReference type="OMA" id="FQMRTHH"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000026">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000027">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF14">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="126"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="328"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ88225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="486" mass="52697" checksum="56E15281D3C7BD5F" modified="2006-03-21" version="1">MQSSRSPTLPPNSSSSSPTPEGEKPKPAQHQQTTPTTPSTHNGLLSPLPLHSAEVGLTRELTPVERIQRIFAVRASGDAGRSGVHPTMFLRNVFRSASWASRIVNVLWPVVPAAIAVRYAMPDNHLVIFILSYLAMVPCANLIGFAGQELSRKFPHVMGVIIETTLGSVVEIIMFIVLITRPANPKIDYIQVIQAAILGSVLATMLLCLGLCFVAGGLKREETHFNEAVSEAGSGLLLTAGFGLAIPTVFEHSLSGKIPQDELIDKTIEISRSTAVLLMIAYLIYIFFQSQTHHGIYDAIFVADEERDADKHLERKHHRLTFTECCIALTVAIALVTIIAIALVDQIHYLVEERGVSDAFVGLILIPLVEKAAEHLTAIDEAYDNQMNFALSHVLGATLQTALFNAPLVVIVGWGLGKPMGLNFEVFDVVVLLLAILTVGNFLRDQKSNYLEGALCVLVYVGIAVAALYYPNPHTIAAAEGGGEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H054</accession>
    <name>Q2H054_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_04842</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224056.1">
        <property type="nucleotide sequence ID" value="XM_001224055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H054"/>
    <dbReference type="STRING" id="306901.Q2H054"/>
    <dbReference type="GeneID" id="4391873"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04842"/>
    <dbReference type="eggNOG" id="ENOG502S8B6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027006_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H054"/>
    <dbReference type="OMA" id="GVFAAPW"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF17">
        <property type="entry name" value="PROTEIN SIMILAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="158"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="219"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="263"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="406"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ88223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="532" mass="59523" checksum="21BF7556BF1F9923" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H066</accession>
    <name>Q2H066_CHAGB</name>
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        <recommendedName>
            <fullName evidence="11">Vps52/Sac2 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_04830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS52 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224044.1">
        <property type="nucleotide sequence ID" value="XM_001224043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H066"/>
    <dbReference type="FunCoup" id="Q2H066">
        <property type="interactions" value="790"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H066"/>
    <dbReference type="GeneID" id="4393019"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04830"/>
    <dbReference type="eggNOG" id="KOG1961">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010797_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H066"/>
    <dbReference type="OMA" id="IHVVMVE"/>
    <dbReference type="OrthoDB" id="19482at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048361">
        <property type="entry name" value="Vps52_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048319">
        <property type="entry name" value="Vps52_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20655">
        <property type="entry name" value="Vps52_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04129">
        <property type="entry name" value="Vps52_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps52 coiled-coil" evidence="7">
        <location>
            <begin position="180"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="8">
        <location>
            <begin position="330"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ88211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="655" mass="71787" checksum="B1FC7F713409E1A0" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0E6</accession>
    <name>Q2H0E6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein transport protein GOT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_04750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GOT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223964.1">
        <property type="nucleotide sequence ID" value="XM_001223963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0E6"/>
    <dbReference type="FunCoup" id="Q2H0E6">
        <property type="interactions" value="730"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H0E6"/>
    <dbReference type="GeneID" id="4392260"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04750"/>
    <dbReference type="eggNOG" id="KOG1743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124519_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H0E6"/>
    <dbReference type="OMA" id="MWLTDAQ"/>
    <dbReference type="OrthoDB" id="204784at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000137">
        <property type="term" value="C:Golgi cis cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ88131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15188" checksum="6B7C0904C4956B1B" modified="2006-03-21" version="1">MPTMWMSDSQKIGVAFCSGGGFFLIAGVLLFFDRAMLAMGNILFLIGLTIIIGPQKTALFFARKQKLKGTAAFFGGLALILLRWPLIGFLVELYGILVLFGDFLGTIATFARNVPVVGPYIGMVVDRVGLGERRNAELPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0Y2</accession>
    <name>Q2H0Y2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_04564</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223778.1">
        <property type="nucleotide sequence ID" value="XM_001223777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0Y2"/>
    <dbReference type="STRING" id="306901.Q2H0Y2"/>
    <dbReference type="GeneID" id="4391569"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04564"/>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H0Y2"/>
    <dbReference type="OMA" id="HIQEDRA"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ87945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="197" mass="21218" checksum="18DBCE2B95CE1374" modified="2006-03-21" version="1">MTIPEIPTVFLKPSTCLADPYPSPTIIPKHTIASDSADYESELAIVLGREAKNVSEADALDYVLGYTASNDISSRASQFAQTQWCYSKGFDGACPIGPVLVSKRLVPDVGKLRLRGLKNGKVVQDSGLTDLIFSVEQIVSFLSQGTTLPKGTVIITGTPAGVGFAHKPQELLHDGDEFVVEIQPHIGSLYNVMQNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H188</accession>
    <name>Q2H188_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_04458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223672.1">
        <property type="nucleotide sequence ID" value="XM_001223671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H188"/>
    <dbReference type="GeneID" id="4391705"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04458"/>
    <dbReference type="eggNOG" id="KOG1611">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_1_1"/>
    <dbReference type="InParanoid" id="Q2H188"/>
    <dbReference type="OMA" id="VEKFRIM"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ87839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="205" mass="22556" checksum="F586158A251BB354" modified="2006-03-21" version="1">MTSKSVFVVGANRGIGFNLVKAFIAESWEVTGTVRPQTCADKDPTVAEKTGAKILELDYLDEETIEKAAAAYGDKPLDMLVDLGGLPPKPGHWHEQTAEVMVEKFRIMTAGPIITTEHFLPKLESATDAKIVNVSSAFGSVSSVVTKAFEWEPEGPQGPLICVEPGFPSTRLTGWDGEDDMDTWIARLMKVSRKSRRRIMRLSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H203</accession>
    <name>Q2H203_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GMP synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="4">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CHGG_04193</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="4"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223407.1">
        <property type="nucleotide sequence ID" value="XM_001223406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H203"/>
    <dbReference type="FunCoup" id="Q2H203">
        <property type="interactions" value="965"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H203"/>
    <dbReference type="MEROPS" id="C26.957"/>
    <dbReference type="GeneID" id="4392660"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04193"/>
    <dbReference type="eggNOG" id="KOG1622">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_0_5_1"/>
    <dbReference type="InParanoid" id="Q2H203"/>
    <dbReference type="OMA" id="IWQSFAV"/>
    <dbReference type="OrthoDB" id="1724632at2759"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="7 15" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 15" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="16">
        <location>
            <begin position="203"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="231"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAQ87574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="438" mass="48158" checksum="232AB5C3871C0E19" modified="2006-03-21" version="1">MAAGPGEAMAHSAFDTILVLDFGSQYTHLITRRLRELNVFSEMLPCTQKLSELKFVPKGIILSGGPYSVYEEGSPHVDPAVFDLNGMQELAYRLNPDNVIAGTHREYGHAMLKARSIDNHVDRLFEGIEESMRVWMSHGDKLAKLPDGFHTVATSDNSEYAAIGHQSKPIYGLQFHPEVTHTQNGTALLKNFAVGICGCKQEWTMQKFLEEAIAQIRHTVGEKGQVLAAISGGVDSTVAAKLMKEAIGSRFWAVLVNNGVMRLNECEQVKKDLTEALGINLTVVEASDRFLDGLKGIDDPEVFRPPPHYYVFIEEAAANDPAKAGKIEFFMQGTLYPDVIESLSFKGPSATIKDEVRALGRALGIREELVMRIFISEIRKAGIYDQISQAYAAVDPSRAVGVMGDKRVYGYVCCATRVLHPLPCRVLLMPGRSSSSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2B0</accession>
    <name>Q2H2B0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223300.1">
        <property type="nucleotide sequence ID" value="XM_001223299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2B0"/>
    <dbReference type="ESTHER" id="chagb-q2h2b0">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="4391944"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04086"/>
    <dbReference type="eggNOG" id="ENOG502QTP8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005757_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2B0"/>
    <dbReference type="OMA" id="KQSHDSW"/>
    <dbReference type="OrthoDB" id="435520at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF10">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="612"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="793"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="983" mass="106605" checksum="1759239DDF3492B3" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2G1</accession>
    <name>Q2H2G1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223249.1">
        <property type="nucleotide sequence ID" value="XM_001223248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2G1"/>
    <dbReference type="GeneID" id="4392391"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04035"/>
    <dbReference type="HOGENOM" id="CLU_1147082_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2G1"/>
    <dbReference type="OrthoDB" id="4761620at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="242" mass="27916" checksum="585467191C301C81" modified="2006-03-21" version="1">MVDSTMSQQNFFADGDDGLGDNGPFNAQHIDPALRAPDTRKRPAPPDNERPGGDDAAAVVAEMAEDDARERKLTSVSHWQVFLYHSRRPENDEENIKAVYGESVDPHSLEWTEARARFMNDQKNLKFRVVKNMEALLKKHAEHPGNALMLDIRVDLSRPVLKDIAHRAFSPENWLKLAMFQGLAVEVAEYLRAKAKDTDTALARRQELLEFYDDMPKKNQYKHLTQAHFHQVFERQRRQKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2T6</accession>
    <name>Q2H2T6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_03910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223124.1">
        <property type="nucleotide sequence ID" value="XM_001223123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2T6"/>
    <dbReference type="STRING" id="306901.Q2H2T6"/>
    <dbReference type="GeneID" id="4392174"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03910"/>
    <dbReference type="eggNOG" id="KOG1474">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033257_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2T6"/>
    <dbReference type="OMA" id="WKKGDPM"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="336"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="231"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ87291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="431" mass="47253" checksum="0522A9A09FA5A2E6" modified="2006-03-21" version="1">MSDEAVPPANGVIDAGSASNASNAGVAVEETATPVEPQPFSWLQPHPLFVIALIGPEETPFGIQKDFLCSKSTFYKKYFDETPDGLENLVRLPDTPVEVFAYAQNFLYTGQVFPSLDNLPTYEVLIGVWKLGNELGIEGLCDATLDAMTECRRVTEHIPATPLLVQVWKDTPEGSSIRKLLLSWAAEYMRSSESRAEFARSLPQEVLSELVVAMSSLDLPPIPIDAIAASGAQRSSAPHELNEAAEGRPSKKRRASDAGLNGTSTVTAAQATVRKPGPRPLLPAIKPGPKPGSKRRASGAVNGAQPFSANQKLNFCADLLSRMLSGPGFWTRVVGPFKDPVDPERDGVPDYLTVVKNPMDLMTMKAKMDGRQYADETEFLADMNQIFTNCYTYWREQDPMWAACEKLQKSFEDKFGQMNKWIAKMEGDEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2Y3</accession>
    <name>Q2H2Y3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Pre-mRNA-splicing factor cef-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_03863</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <text evidence="8">Involved in pre-mRNA splicing and cell cycle control.</text>
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        <text evidence="1">Belongs to the CEF1 family.</text>
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        <location>
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        </location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
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                <person name="Untereiner W.A."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ87171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H386</accession>
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        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">CHGG_03760</name>
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    <organism evidence="3 4">
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        <lineage>
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            <taxon>Sordariomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001222973.1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR010730">
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    </dbReference>
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        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
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            <begin position="103"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="666" mass="73203" checksum="4D07AE14C4803CD1" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3M1</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CHGG_06744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222839.1">
        <property type="nucleotide sequence ID" value="XM_001222838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3M1"/>
    <dbReference type="GeneID" id="4390767"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06744"/>
    <dbReference type="HOGENOM" id="CLU_2305763_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3M1"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="100" mass="10739" checksum="42F4F210673110F4" modified="2006-03-21" version="1">MREDNNDDGDDTSFPTLSNNPTHPYHNNTITITATDLTPTPDGLRNNLREGMSDDGRECGRPRPHALPTPARPPTPPPNPRPGPQAPRPPPGTPSPPPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3S1</accession>
    <name>Q2H3S1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein-sorting-associated protein 46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222789.1">
        <property type="nucleotide sequence ID" value="XM_001222788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3S1"/>
    <dbReference type="FunCoup" id="Q2H3S1">
        <property type="interactions" value="611"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H3S1"/>
    <dbReference type="GeneID" id="4391200"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06694"/>
    <dbReference type="eggNOG" id="KOG3232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125118_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3S1"/>
    <dbReference type="OMA" id="QQITMVM"/>
    <dbReference type="OrthoDB" id="10266568at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23100" checksum="412DDB4DD00DF27E" modified="2006-03-21" version="1">MSNRQLSRDMQTEFQARFNAKQARREAQKAAKQDNELKKQIQNLLKKGETAQAAQKARMLLAKQAIAAQMDQAADIAELSLAQIQANNAMNRMTTMMSQSSKTMQRAQRSANPEKTLLTLEQFRSQNEEYAMNNGIYQDAMTQNTSVQVSDDSVQELLGKLADDAGLELGQELNEASTSKVDPVKEPAEPTPEVEDALQQRLRALRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4X1</accession>
    <name>Q2H4X1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_06294</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222389.1">
        <property type="nucleotide sequence ID" value="XM_001222388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4X1"/>
    <dbReference type="FunCoup" id="Q2H4X1">
        <property type="interactions" value="232"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H4X1"/>
    <dbReference type="GeneID" id="4390727"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06294"/>
    <dbReference type="eggNOG" id="KOG1589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099502_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H4X1"/>
    <dbReference type="OMA" id="FRQNFYQ"/>
    <dbReference type="OrthoDB" id="869189at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ89675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="153" mass="17148" checksum="9D556CDA1E152077" modified="2006-03-21" version="1">MSPSSNFFRAARPAFRARQFFFRPKQGARFQSTTADAGAESWAKRMWNSPVGLKTVHFWAPVMKWALVLAGVSDFARPAEKLSLTQNAALTSTGLIWTRWCLIIKPKNYLLAAVNFFLGVVGVVQCTRILMWQQSQKGLPAKVEEVKEAVVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5N7</accession>
    <name>Q2H5N7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222123.1">
        <property type="nucleotide sequence ID" value="XM_001222122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5N7"/>
    <dbReference type="GeneID" id="4390468"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06028"/>
    <dbReference type="HOGENOM" id="CLU_1085864_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5N7"/>
    <dbReference type="OMA" id="HALMENY"/>
    <dbReference type="OrthoDB" id="10675289at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="256" mass="24534" checksum="1AA16151988EE69D" modified="2006-03-21" version="1">MPTSTSSSPSASGAGNAGNASPTLAPSSQAPKRYRGLSAYRWAPAPSPSSGPSPSSSALVPAPSLFSGPSPSSSALAPPPASSVPASSPVPSSSVSASAPAPSSPTAPKRYRGLSVSRWAPAPAPSPSGPASAPSSSSAASPSAPVSPGAPSDSPPSPVLVPSLGSPSSSVSALSLSSPLLPGSPPSLGSSPNPASASPPAPATPDPPPTPDSPPPTPAAPHRPKAVRRSDGSTVTVINDMKPGEKGLAASQWAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5Y9</accession>
    <name>Q2H5Y9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cystathionine gamma-synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_05926</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
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        </cofactor>
    </comment>
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        <text evidence="4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
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    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2 3 4" id="KW-0663">Pyridoxal phosphate</keyword>
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            <position position="226"/>
        </location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="EAQ89307.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="47317" checksum="E36A8B8BDA01E77D" modified="2006-03-21" version="1">MVSNGNTEKKAAGAGPDQLAAAFGRQLSLASRSVHADDYTNTHTAVAPPMHVSTTFRYPRNPDELVAWSDVEPEKWDDFYIYSREKSPNTTRYEAILSSILGGPAVSYASGLAAFHAMVVFLNPKRVAIGGGYHGCHGILKLMNKLNGLEQLELENEDDLAKLQKGDIIHVETPLNPTGEARDLAYYRKKADELGCYLTVDATFAPPPLQDPFKYGVDIIMHSGTKYFGGHSDMLSGVLAIHPDRAGSKDGKPGWLTEIREERLHLGGVMGSFEGWLGTRSLRTLELRVKRQSETTRNLVDWLASQKKAGGNVVADLVYKLQHSSQQPEASDPDSWLSKQMPNGHGPVFSLWLQSEELAKRLPSKLFLFHHATSLGGIESLVEWRAMSDTTVDRRLVRVSIGVESWEDLRDDLLQGFQALHKELNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H629</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CHGG_05886</name>
    </gene>
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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    </organism>
    <reference evidence="3" key="1">
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89267.1"/>
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    </dbReference>
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    <dbReference type="GeneID" id="4390017"/>
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    <dbReference type="OrthoDB" id="10390289at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="293" mass="30787" checksum="C2D7BBCCB6FEC8ED" modified="2006-03-21" version="1">MLPSRKGGDGDYQAASGLDNGQMKGRLRNKGPCSPREAPAFWCAEREKNSRSPTWGVVNCDCWVRLPCLFARTEFGKIAGKAPAAAGPRRKTQLPDYVPSRAVSQGQVVYAQCIECIFLAMARPGLLEKATPTSNEHPLSPLGSLAYPSGCPNPLRDSLPEERAVHPAVRSVEGAASQGGSPNTSLLGCFCSATCQIFSVAGATRTVTFPIPASASIEAPTSWATSWATSWATSWAGSAHLAANPLAKSNPPGRRHSTMHPPSGNVGIVGSADGALISLAACRCCQIWKLQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6A5</accession>
    <name>Q2H6A5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LPXTG-motif cell wall anchor domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001221904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6A5"/>
    <dbReference type="STRING" id="306901.Q2H6A5"/>
    <dbReference type="GeneID" id="4391286"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05810"/>
    <dbReference type="eggNOG" id="ENOG502S1ZU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003899_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6A5"/>
    <dbReference type="OMA" id="RFTHRRP"/>
    <dbReference type="OrthoDB" id="5369729at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="884"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="942"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="525"/>
            <end position="541"/>
        </location>
    </feature>
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        <location>
            <begin position="561"/>
            <end position="574"/>
        </location>
    </feature>
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        <location>
            <begin position="743"/>
            <end position="753"/>
        </location>
    </feature>
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        <location>
            <begin position="792"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="836"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="948"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="981" mass="106435" checksum="4C4393CAAB7093BA" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6B4</accession>
    <name>Q2H6B4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_05801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221896.1">
        <property type="nucleotide sequence ID" value="XM_001221895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6B4"/>
    <dbReference type="GeneID" id="4390930"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05801"/>
    <dbReference type="HOGENOM" id="CLU_3014021_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6B4"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="56" mass="6331" checksum="2E36780B8C728E4F" modified="2006-03-21" version="1">MAPEPGTEAVHELWRRASICRVRHIRSSRCSRNTAKPYPCQLIGTENGDEYFAPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6C8</accession>
    <name>Q2H6C8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221882.1">
        <property type="nucleotide sequence ID" value="XM_001221881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6C8"/>
    <dbReference type="GeneID" id="4390169"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05787"/>
    <dbReference type="eggNOG" id="ENOG502SD3B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112553_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6C8"/>
    <dbReference type="OMA" id="WKHAISF"/>
    <dbReference type="OrthoDB" id="4159136at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF1">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="183" mass="18939" checksum="F7519F940E251DD8" modified="2006-03-21" version="1">MSSDVFRRVGRGGAGNFYSQQDVQDAEKKAATTTDLEAQDQPANALTLTPTHATGSSSLGPGTNYTRAGRGGAGNFTFSPSAATNEVTGAPTSSADAAAQKQQEKEEADRAKANAAVVASLAAKSRAGGLSGRGGAGNWSFGGGGREEEEAEVRRREEELERKILRDVEVGLAPPAKAYVPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6M5</accession>
    <name>Q2H6M5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein RER1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_05690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RER1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221785.1">
        <property type="nucleotide sequence ID" value="XM_001221784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6M5"/>
    <dbReference type="FunCoup" id="Q2H6M5">
        <property type="interactions" value="760"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H6M5"/>
    <dbReference type="GeneID" id="4390329"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05690"/>
    <dbReference type="eggNOG" id="KOG1688">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074889_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6M5"/>
    <dbReference type="OMA" id="GWYVVCY"/>
    <dbReference type="OrthoDB" id="448250at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016013">
        <property type="entry name" value="AtER_Rer1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ89071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="190" mass="22367" checksum="A6519FCBD079DDA5" modified="2006-03-21" version="1">MDVPDEPQTPFSTVTAQTNKLQRQYQALLDQSTPFVLYRWIGTGVALFFFFVRVFFAQGWYIVAYALGIYLLNLFLAFLQPKFDPSNDALDNDMEDGAIGSLPTKQDEEFRPFIRRLPEFKFWHSATRAVAISFACSWFEVFNVPVFWPVLVMYWFMLFILTMRKQIQHMIKYRYVPFTVGKARYTKNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H744</accession>
    <name>Q2H744_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">O-methyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_05521</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221615.1">
        <property type="nucleotide sequence ID" value="XM_001221614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H744"/>
    <dbReference type="STRING" id="306901.Q2H744"/>
    <dbReference type="GeneID" id="4391134"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05521"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_1_4_1"/>
    <dbReference type="InParanoid" id="Q2H744"/>
    <dbReference type="OMA" id="QERYMRN"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF5">
        <property type="entry name" value="O-METHYLTRANSFERASE ASQN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="194"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ88901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="431" mass="47894" checksum="CDBE6488523F0B84" modified="2006-03-21" version="1">MPSPTSLLSELAEEISRNTSIIVERLKSGGLPQPSFDADGPSHPIPEADEELSAARHALIEASKALHTLAVGPSETTRLFYFKDIYFVGAMQVLCHFNVPQQVPISGEIGIHELSVKTGLDRGLLVRFLRIAAANYYFTEPRRGFFAHTAWSKTLAIDPKMRACVWFRHSEMMPSVAKLVEAVEMHTGSAEAAEPRNAAFSLAFGDSFFDYKEKHPDHMIKFGHFVDAFAGGIEADTAESIARAYAWETLPANSLVVDVGGGIGHISTAVAQKHAHLSFQVQDFGDLVEESGTLQQSAGVSDRVHFCPHSFFEPQPETCRKAAVYFLRNIMHNWPDLYCRRILEPIVEAMGPDSRLLICDIVLPEPNTMPKTQEAQVRALDIVMLSMFNAQERSYEDWQELLTSVDSRLRITAVVGRPKLGIDNLIEARLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H764</accession>
    <name>Q2H764_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="9">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_05501</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the helicase family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001221595.1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05501"/>
    <dbReference type="eggNOG" id="KOG0987">
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    <dbReference type="HOGENOM" id="CLU_001613_8_1_1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0006281">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
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    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
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        <property type="entry name" value="PIF1_helicase"/>
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    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
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    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 9" id="KW-0547">Nucleotide-binding</keyword>
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        <location>
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        <location>
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        <location>
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            <end position="1287"/>
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    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="14">
        <location>
            <begin position="1364"/>
            <end position="1396"/>
        </location>
    </feature>
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        <location>
            <begin position="108"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1060"/>
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        </location>
    </feature>
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        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1067"/>
            <end position="1078"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ88882.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1533" mass="173975" checksum="AB73A19495185DF3" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H787</accession>
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        <recommendedName>
            <fullName evidence="7">Nudix hydrolase domain-containing protein</fullName>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Untereiner W.A."/>
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            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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        <property type="entry name" value="DNA TOPOISOMERASE 2-BINDING PROTEIN 1"/>
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        <property type="match status" value="4"/>
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        <property type="match status" value="4"/>
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="182"/>
        </location>
    </feature>
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        <location>
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            <end position="278"/>
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        <location>
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            <end position="624"/>
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    <feature type="domain" description="BRCT" evidence="3">
        <location>
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            <end position="722"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        <location>
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        <location>
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    </feature>
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        <location>
            <begin position="1087"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="442"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="738"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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    </feature>
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        <location>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1087"/>
            <end position="1099"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ88859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1107" mass="120828" checksum="CFEE1A9B5913073D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7R4</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CHGG_05301</name>
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    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221396.1">
        <property type="nucleotide sequence ID" value="XM_001221395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7R4"/>
    <dbReference type="GeneID" id="4391485"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05301"/>
    <dbReference type="eggNOG" id="ENOG502RNUX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075595_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7R4"/>
    <dbReference type="OMA" id="PSGEYPY"/>
    <dbReference type="OrthoDB" id="2873061at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="319" mass="35140" checksum="EB5E10557AAADBBD" modified="2006-03-21" version="1">MPSSRRSSRAGSSGGKKDSKVPPEILHQFGRAILSYSLKKLSEQKAPSKSRSQSSRRKSSRSKPREPSSASKRGSSRDLPRSDSGDMHALVSQLAVGVFAFGIRALIRRRKEAKKKAAAAAAAAGTRSVPGDPGGAGDKKVGAGAVDPELSAALDSVTQELQGVSDSIRRLAHSAPPPSHRDCMVRNVLVADADRLTGSLANMQASIHNMKNLHPGLEQGMRSRQQSTRREGFRERGGVDEVDRRTEKRATRSRGTPRTEEARSRSRRVDLTREEESDEGHRSHRGYRTRVQPGERHRHRRRRDDEEVPPGRRPAPLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7T0</accession>
    <name>Q2H7T0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_05285</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221380.1">
        <property type="nucleotide sequence ID" value="XM_001221379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7T0"/>
    <dbReference type="STRING" id="306901.Q2H7T0"/>
    <dbReference type="GeneID" id="4391357"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05285"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022195_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H7T0"/>
    <dbReference type="OMA" id="DPNRFHF"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208604" description="Cytochrome P450" evidence="9">
        <location>
            <begin position="24"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ88666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="50365" checksum="3850B7BC6DA128B2" modified="2006-03-21" version="1">MSVALVSTVLVAAAAWLVLRVRASGPKLDIPYLQFEGDNSLLRYLNDTRSLMRKGYAEYIKQGKPFSMLNHVDFLSPLVILPPKYLEEVRSAPQTKLSFPLSLEKFLLNVFSRITARSLVGPELCDSQEWQDIILGFTNSAFKASHGVRVRYHPWTRWLAKYFDGDVKDVYRYRKRAGNLLRPILEARKAEYKARGKGEKVEHEDGIQWILDAYHSTGSTLTPDKLAQDEFIITIASIHSSAATALSILYDLMDRPECLAEIQEEISKVFMQYGSWTRQSLAALRIMDSFMKESQRVHTLQQLTLQRMVVEDFTFKDGLHLPAGTQMAMPNELISLDPDLHENAETFDAKRFLRKREQIDPNKFHFASISEDMLPFGSGLHACPGRFLAQDVMKLMFIRLLTRYEFKYPEGVESRPANIERHHNIMPNTGLSLLFKEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7Y8</accession>
    <name>Q2H7Y8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Copper acquisition factor BIM1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_03666</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230182.1">
        <property type="nucleotide sequence ID" value="XM_001230181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7Y8"/>
    <dbReference type="GeneID" id="4388437"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03666"/>
    <dbReference type="eggNOG" id="ENOG502S92W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070647_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H7Y8"/>
    <dbReference type="OMA" id="QIFPIVQ"/>
    <dbReference type="OrthoDB" id="2146436at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21176">
        <property type="entry name" value="LPMO_auxiliary-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF1">
        <property type="entry name" value="COPPER ACQUISITION FACTOR BIM1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208608" description="Copper acquisition factor BIM1-like domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="10">
        <location>
            <begin position="19"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ91731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="222" mass="22578" checksum="EDB069F9E39BEC8B" modified="2006-03-21" version="1">MVSLRSLFAAGALCLSAANAHFELRQPPSLEGDNMNEDLEPNAPCGGGVADLSTNKVVDFHVDGDAVAWFLGHPQAKWLIRGTLDSKAAGNWTEMYPIIQQDGRGEYCQPAVTAPKAWAGKKGIISVACGAPDGLLFQCAAVNFVSGANTSPSPCNNGSVNANFSEDPNLTALLDASTTTSPGPPESTSGSAAPSLILPGSGLSIGGLAVTAVMLLVGAAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H885</accession>
    <name>Q2H885_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Nuclear membrane fusion protein Kar5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_03569</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for nuclear membrane fusion during karyogamy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the KAR5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230085.1">
        <property type="nucleotide sequence ID" value="XM_001230084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H885"/>
    <dbReference type="GeneID" id="4388747"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03569"/>
    <dbReference type="eggNOG" id="ENOG502QQCT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039421_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H885"/>
    <dbReference type="OMA" id="VIPRECA"/>
    <dbReference type="OrthoDB" id="5311848at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000742">
        <property type="term" value="P:karyogamy involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048288">
        <property type="term" value="P:nuclear membrane fusion involved in karyogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007292">
        <property type="entry name" value="Nuclear_fusion_Kar5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012:SF1">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0415">Karyogamy</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209343" description="Nuclear membrane fusion protein Kar5" evidence="13">
        <location>
            <begin position="22"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ91634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="38063" checksum="880ED8989C9E235E" modified="2006-03-21" version="1">MQARSLILALLVLCINGFTWGNGRSGRAVPTLDKPDELPSSSRLPNIYAVALTELQELELHPLCHRVAARLLVNNCELVDGKDEATILTDSGQKVRDFVDSYAASLAICDLERGNFVIPAECAKFREPSLSQIAIRNEPQLHVSSGEIGLCLAALAASDAAWNTWVSYRHKALRFCEAARADHEKDLDLALRQSSKSIKDGLQHADNLQQLLRMLLANVVESNSQLALAYEQSLQRASQRVNDDMGALVAVLSIAMTSSNSLQKQIASMLAQRQETLHHGMDRLAIATETLSEKFEDHSGSYGLPPSILRNLALLALGGLVGFMVSSYDQLTTQLFGALQATANITASSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8G7</accession>
    <name>Q2H8G7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_03487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230003.1">
        <property type="nucleotide sequence ID" value="XM_001230002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8G7"/>
    <dbReference type="GeneID" id="4388881"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03487"/>
    <dbReference type="eggNOG" id="ENOG502T3E5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054614_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8G7"/>
    <dbReference type="OMA" id="PGRWIFD"/>
    <dbReference type="OrthoDB" id="4564076at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ91552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="276" mass="31046" checksum="880965490967C384" modified="2006-03-21" version="1">MDQIPVVSPFRGHITAPPPADSPLAYNEDVIVNLVIQILTMLISIGHIKAERILFAPPGGHTDIDEAVCAELNLAPRVVSLLKRLPYWTSSEFVEWAQVRPDSYLPNYRDPEHLRLGRRVCGLPIGKDTIRRSDNSAVVLDHIRQEFPDYVPEFPEEPNHYRNRVALHAPTVLADYIDDLRRLDFMPTGGLGTGEATVVSTGWEPGMAVVRDALLQRYGWPDEFRAEEWRQEGRAIYDTARQGVSWGPGGFGLPLNEMQVPGLHPDVIQYLQRRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8M8</accession>
    <name>Q2H8M8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_03426</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229942.1">
        <property type="nucleotide sequence ID" value="XM_001229941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8M8"/>
    <dbReference type="GeneID" id="4389704"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03426"/>
    <dbReference type="eggNOG" id="KOG2029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_287700_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8M8"/>
    <dbReference type="OMA" id="MFFATPH"/>
    <dbReference type="OrthoDB" id="5967843at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="273"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="663"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="729"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="877"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="672"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="729"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="754"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="944"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ91491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1070" mass="119438" checksum="145471AB5D9138D0" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8T9</accession>
    <name>Q2H8T9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylulose kinase</fullName>
            <ecNumber evidence="7">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_03365</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2005-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Giovannoni S.J."/>
                <person name="Cho J.-C."/>
                <person name="Ferriera S."/>
                <person name="Johnson J."/>
                <person name="Kravitz S."/>
                <person name="Halpern A."/>
                <person name="Remington K."/>
                <person name="Beeson K."/>
                <person name="Tran B."/>
                <person name="Rogers Y.-H."/>
                <person name="Friedman R."/>
                <person name="Venter J.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 148.51</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2006-02" db="EMBL/GenBank/DDBJ databases">
            <title>Annotation of the Chaetomium globosum CBS 148.51 Genome.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Birren B."/>
                <person name="Lander E."/>
                <person name="Galagan J."/>
                <person name="Devon K."/>
                <person name="Nusbaum C."/>
                <person name="Ma L.-J."/>
                <person name="Jaffe D."/>
                <person name="Butler J."/>
                <person name="Alvarez P."/>
                <person name="Gnerre S."/>
                <person name="Grabherr M."/>
                <person name="Kleber M."/>
                <person name="Mauceli E."/>
                <person name="Brockman W."/>
                <person name="Rounsley S."/>
                <person name="Young S."/>
                <person name="LaButti K."/>
                <person name="Pushparaj V."/>
                <person name="DeCaprio D."/>
                <person name="Crawford M."/>
                <person name="Koehrsen M."/>
                <person name="Engels R."/>
                <person name="Montgomery P."/>
                <person name="Pearson M."/>
                <person name="Howarth C."/>
                <person name="Kodira C."/>
                <person name="Yandava C."/>
                <person name="Zeng Q."/>
                <person name="Alvarado L."/>
                <person name="Oleary S."/>
                <person name="Untereiner W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 148.51</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>D-xylulose + ATP = D-xylulose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="7"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229881.1">
        <property type="nucleotide sequence ID" value="XM_001229880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8T9"/>
    <dbReference type="FunCoup" id="Q2H8T9">
        <property type="interactions" value="442"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H8T9"/>
    <dbReference type="GeneID" id="4388517"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03365"/>
    <dbReference type="eggNOG" id="KOG2531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016149_5_0_1"/>
    <dbReference type="InParanoid" id="Q2H8T9"/>
    <dbReference type="OMA" id="NSCALGG"/>
    <dbReference type="OrthoDB" id="1728974at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:D-xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005998">
        <property type="term" value="P:xylulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07776">
        <property type="entry name" value="ASKHA_NBD_FGGY_SpXK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000118">
        <property type="entry name" value="Xylulose kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042024">
        <property type="entry name" value="D-XK_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF57">
        <property type="entry name" value="XYLULOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="8">
        <location>
            <begin position="294"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ91430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="572" mass="62471" checksum="A0027BF3CB24A3D7" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8X1</accession>
    <name>Q2H8X1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_03333</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229849.1">
        <property type="nucleotide sequence ID" value="XM_001229848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8X1"/>
    <dbReference type="STRING" id="306901.Q2H8X1"/>
    <dbReference type="GeneID" id="4389635"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03333"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_25_3_1"/>
    <dbReference type="InParanoid" id="Q2H8X1"/>
    <dbReference type="OMA" id="WGADIEN"/>
    <dbReference type="OrthoDB" id="4841169at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ91398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="500" mass="55677" checksum="B30DD89768C20F20" modified="2006-03-21" version="1">MGNRAHRSTELAVRLVVAQVQEAWRQKGAASLLQLDISGAFDTVNHTRLLATLREMGFPRWLVLWTRDWLTGREATLLFDGKTAAPTAIRAGVPQGSPLSPVLFILYISSLYKQLKDEHPHLAITGFADDTNLLVFGRNPEANVRTCIRWADSRGMKFAPEKSELIHFNKGRRQWTEQVNLANPGGGTSPVKPEESARFLGVWLDWKLNWKAHLVAVEKKLRTQSYALSRIVAKTWGMGLAKAREVYTKCIRSALAYGASSFHIPTDVGGEPAKKGITKALGKTQNKSLRIVAGAFKSTPIRNLETETWVPPLDLYLNKRLADFENRLQRPDLDDGRGGKKTAASVFLTACRKIQQRLSSRRGNRGRPRTLGSQGPTAVERAAGTVMRWTGGTVDTNRVVEEAWKARWLKERDGRAITRPADDFDHQRETLFRNETLRRHDGLSKAKSSLLYSNPDGSNRLTGLLVYTGSPGGSDSCLRVWRGTRDCRTPGSVVFGPTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H941</accession>
    <name>Q2H941_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229779.1">
        <property type="nucleotide sequence ID" value="XM_001229778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H941"/>
    <dbReference type="GeneID" id="4389303"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03263"/>
    <dbReference type="HOGENOM" id="CLU_2483153_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H941"/>
    <dbReference type="OrthoDB" id="4589651at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="87" mass="8982" checksum="DA27EFBADED2CE6C" modified="2006-03-21" version="1">MAPSRPPPEDPESSGGRSGLSRKAPRWSAIPCAALIGVAAKASTIRHGSVRTHLKLMLPGYAAGVGWQTLVFVVVTRSGGDSMLLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9D3</accession>
    <name>Q2H9D3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_03171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229687.1">
        <property type="nucleotide sequence ID" value="XM_001229686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9D3"/>
    <dbReference type="GeneID" id="4389592"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03171"/>
    <dbReference type="eggNOG" id="ENOG502SM2Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044113_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9D3"/>
    <dbReference type="OMA" id="HGEYMFG"/>
    <dbReference type="OrthoDB" id="3535423at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ91236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="495" mass="56337" checksum="6F53191A4C07E849" modified="2006-03-21" version="1">MTSSPKVHNTIAVNSGCLCFGELHNIWNGASVPVQFEGLPSPRPRLSGTVKVHRIEYNIAARNGIWNGFRLIDLKTKKVAAWFLAHSDVDPEKEVDKILRVSGSPYEDESGSSFNDDKTAAEGVFVINRYDWGYYDERSREIVEPEEINEELFASVGLVDLSAAKPTVDRWKDHRSRERQWLEGGAWLHIPNGEYLFGRFGFDDDHAAARSFLFFTTNTYFTRTAFDGLERTLRKEVTPEERFERKLQEGFDFSGLETLRELSRVPEHSGVSRPPRADCLGPYRQSDHVLRAQEIDAIRVYRDAEELKLFVHGRDLSHLRMEGEIGEFIEPWAEPLYDVVNEMVLSYLQRSVIPNMANRGVSAAAELLFPQHTPEEDTGKLDVWCHRHFRQPDARPIPNFDSAYVGSRIASFLSRSADASAVFEDECVAGITRAVAYMLTDVLERASKGAHQDDMRTRIMPSDVRIAVSLSSELHDRFRFSIVYWEGRTGSVSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9H3</accession>
    <name>Q2H9H3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229647.1">
        <property type="nucleotide sequence ID" value="XM_001229646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9H3"/>
    <dbReference type="STRING" id="306901.Q2H9H3"/>
    <dbReference type="GeneID" id="4389120"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03131"/>
    <dbReference type="eggNOG" id="ENOG502RAQ3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_510893_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9H3"/>
    <dbReference type="OrthoDB" id="5362630at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF3">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209099" evidence="1">
        <location>
            <begin position="19"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="533" mass="59731" checksum="67AB072AB783AFFE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9K9</accession>
    <name>Q2H9K9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229611.1">
        <property type="nucleotide sequence ID" value="XM_001229610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9K9"/>
    <dbReference type="GeneID" id="4389506"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03095"/>
    <dbReference type="HOGENOM" id="CLU_2775728_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9K9"/>
    <dbReference type="OrthoDB" id="4590573at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="69" mass="7578" checksum="00F2267C6CA0D936" modified="2006-03-21" version="1">MDSLTEQLGGETPESVIESHNLPELEYERDRAETAVKEAESNIAARQEALGDTNNMQGPHNKGRLLQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9S9</accession>
    <name>Q2H9S9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229541.1">
        <property type="nucleotide sequence ID" value="XM_001229540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9S9"/>
    <dbReference type="GeneID" id="4388538"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03025"/>
    <dbReference type="eggNOG" id="KOG1124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_860526_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9S9"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054464">
        <property type="entry name" value="ULD_fung"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22893">
        <property type="entry name" value="ULD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="80"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="323" mass="35481" checksum="E9AF7A68F0CE3227" modified="2006-03-21" version="1">MATAGEIIAITARSTWTGIRRQVAAMGRMVKRMGSLVKDVRELFVFLAACSKEMLAEIGRNTHLKRVIQVIEAMPRDLGVDIIRLDDAWGETWGLPLQACGSWESFCDLLQGVVYAGKPGLDQVASGQFAITLAKRGDFNLNSFSWDSSLEKKLHIEQAIVVPRAYSRPSKGCPFPGCCGTTVLEVKGKMRCSTCGRQAAIRRRPQSIINIQHASDQSPEPQPGILPTSHGLGSPPIQLVGGEYQHFRRLQFQEPAKPVQNSREILHRLVEDFRDVTANAYSGNLILQVVEVDNPWSPDETVVALKHAVSCLGRAIISGELPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9T3</accession>
    <name>Q2H9T3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PH-response regulator protein palH/RIM21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_03021</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the palH/RIM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229537.1">
        <property type="nucleotide sequence ID" value="XM_001229536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9T3"/>
    <dbReference type="STRING" id="306901.Q2H9T3"/>
    <dbReference type="GeneID" id="4388603"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03021"/>
    <dbReference type="eggNOG" id="ENOG502QWMT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014594_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H9T3"/>
    <dbReference type="OMA" id="AWVVYYA"/>
    <dbReference type="OrthoDB" id="5393256at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014844">
        <property type="entry name" value="PalH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH/RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH_RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08733">
        <property type="entry name" value="PalH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="396"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="508"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="673"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="521"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="572"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ91086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="801" mass="86701" checksum="930F3DEFEFB1C101" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HA00</accession>
    <name>Q2HA00_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_02954</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the GSE complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229470.1">
        <property type="nucleotide sequence ID" value="XM_001229469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HA00"/>
    <dbReference type="FunCoup" id="Q2HA00">
        <property type="interactions" value="518"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HA00"/>
    <dbReference type="GeneID" id="4389777"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02954"/>
    <dbReference type="eggNOG" id="KOG3887">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047421_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HA00"/>
    <dbReference type="OMA" id="NCRTFQE"/>
    <dbReference type="OrthoDB" id="26136at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11385">
        <property type="entry name" value="RagC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000643">
        <property type="entry name" value="Small monomeric GTPase (Gtr2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039400">
        <property type="entry name" value="RagC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ91019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="343" mass="39348" checksum="11C7A542C57D6212" modified="2006-03-21" version="1">MSSASAEEDADVPADTTSGPSRPRPVRYISPAALNLHRVYEQNRQRLQKKDGAKVPDATTPQTKGRPRLLLMGQRRSGKSSISSVVFHKLPPTETLFLESTARIQKDSLSSFMEFQVWDFPGQIDIFDNPNFTFDMDAIFGEIGALIWVIDAQDDYLEAVARLNATILHLHRSYPHINIEVFIHKVDGLSDDYRLDIQRDVTIRIQDELSDQGVENAPVNFHLTSIYNHSIFEAFSKVIQKLIPRLGQLEAMLTNLCRTCRFEKAYLFDVNTKIYIATDNTPEDMASYEICSDYVDVFIDFTEVYGSWPRSEHWRERLEGEPWAQPLDDQVACEWAICHRLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HA15</accession>
    <name>Q2HA15_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DDT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_02939</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229455.1">
        <property type="nucleotide sequence ID" value="XM_001229454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HA15"/>
    <dbReference type="FunCoup" id="Q2HA15">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HA15"/>
    <dbReference type="GeneID" id="4389097"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02939"/>
    <dbReference type="eggNOG" id="KOG1245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002631_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HA15"/>
    <dbReference type="OMA" id="FVEVHCA"/>
    <dbReference type="OrthoDB" id="332390at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028942">
        <property type="entry name" value="WHIM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013136">
        <property type="entry name" value="WSTF_Acf1_Cbp146"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075:SF6">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02791">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10537">
        <property type="entry name" value="WAC_Acf1_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15612">
        <property type="entry name" value="WHIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51136">
        <property type="entry name" value="WAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAC" evidence="8">
        <location>
            <begin position="42"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="DDT" evidence="7">
        <location>
            <begin position="408"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="340"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="475"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="680"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="941"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1035"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="650"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="481"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="731"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="941"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="969"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1056"/>
            <end position="1071"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ91004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1082" mass="122910" checksum="52FC4E3E45008E68" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAV6</accession>
    <name>Q2HAV6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LCCL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_02648</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229164.1">
        <property type="nucleotide sequence ID" value="XM_001229163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAV6"/>
    <dbReference type="FunCoup" id="Q2HAV6">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="GeneID" id="4389491"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02648"/>
    <dbReference type="eggNOG" id="ENOG502QUEX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011125_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HAV6"/>
    <dbReference type="OMA" id="KHWRWIP"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF8">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G02970)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50820">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="376"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="3">
        <location>
            <begin position="192"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ90713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="638" mass="71063" checksum="78733DE78C4769E0" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HB44</accession>
    <name>Q2HB44_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamyl-tRNA synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_02560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229076.1">
        <property type="nucleotide sequence ID" value="XM_001229075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HB44"/>
    <dbReference type="STRING" id="306901.Q2HB44"/>
    <dbReference type="GeneID" id="4388793"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02560"/>
    <dbReference type="eggNOG" id="ENOG502S0KS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085403_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HB44"/>
    <dbReference type="OMA" id="YAQKMTK"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025255">
        <property type="entry name" value="DUF4202"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41729">
        <property type="entry name" value="GLUTAMYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41729:SF1">
        <property type="entry name" value="GLUTAMYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13875">
        <property type="entry name" value="DUF4202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ90625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="24423" checksum="FA5FD2BBC213BF8C" modified="2006-03-21" version="1">MASLPPLEPNYATALQLIDEAHATDPRTVPSANPDDDTPIPFELDYARKMTRWLAVREPNASPALQLACRAQHFRRWELPRTSYPPTRPGYLTWRAKQKSQAAAQLTTLLTTSPTIHPPLPESSIDRIAALVRKDGLSGGANANANEETQVLEDVACLVFLDGQLEGFERESGVEEAKLVGILRKTWGKMSERGKELALGMELGERARVLVGKALVGEGEGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBJ6</accession>
    <name>Q2HBJ6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_02408</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228924.1">
        <property type="nucleotide sequence ID" value="XM_001228923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBJ6"/>
    <dbReference type="ESTHER" id="chagb-q2hbj6">
        <property type="family name" value="Hormone-sensitive_lipase_like"/>
    </dbReference>
    <dbReference type="GeneID" id="4389820"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02408"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_3_1_1"/>
    <dbReference type="InParanoid" id="Q2HBJ6"/>
    <dbReference type="OMA" id="VIALHYW"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="103"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ90473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="400" mass="43363" checksum="0C1C9218CDE79B82" modified="2006-03-21" version="1">MTNLTQRKQRNDTNPKADHDKEVVLRREPPPFLTKLMYAGYMYGLKSILGPVLWLRDWQESRAPPMGWPDMIKTYDCRPQLPVRIFLPRAYNKNSQATLPTLFTIHGGGFCIGHQRDDDEWNRAFANTQSVLVISLNYSKAPAHPFPTGLHDLEALLLAVLADASLPIDRTTTSPTSRTAILGFSAGANLALSVSQLPTIHTHPLTPAAALSVYGCLDVSYPPHEKLPNRPWKTSLPPPRNSPTDGLISLAPAFDWSYIPYGQALRDPLLSPHHAARDALPPNVCVVAAELDMLAHESWRFACRLSREGFGAGRGERVVPDRGSAEARWRELGGGEGGDEGCGVEDRGVYGGGREVVEGCGVAGVVGTWGGVVNSETGSGAGEGVYGLAGRARFLHLFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCT8</accession>
    <name>Q2HCT8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-hydroxyacyl-CoA dehydrogenase type-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_01966</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221187.1">
        <property type="nucleotide sequence ID" value="XM_001221186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCT8"/>
    <dbReference type="STRING" id="306901.Q2HCT8"/>
    <dbReference type="GeneID" id="4386281"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01966"/>
    <dbReference type="eggNOG" id="KOG1199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_42_0_1"/>
    <dbReference type="InParanoid" id="Q2HCT8"/>
    <dbReference type="OMA" id="WAQRTIG"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ93731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="26086" checksum="4584E77B10EB601E" modified="2006-03-21" version="1">MKISGRTFIISGGASGLGRACARDICSLGGHAAILDMNSEQGSALQHHLGRDSGGRLGDPKRQAAGRGDPSRRGWGCPGWCWTGTCSRWGWRQVDFVLGVNLRGRWIWCGRCCRILGRGPGEGPDGERGVVVMVSSAAAFEGQMGQVAYAASKGAVAAMTLPMARDLARFGIRVVTIAPSMFESNMTAHMSEKVRVGLKKAMEFPARPGQPEEFASLVRQAIENVMLNGVVIRLDGATRMPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HD72</accession>
    <name>Q2HD72_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_01832</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221053.1">
        <property type="nucleotide sequence ID" value="XM_001221052.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HD72"/>
    <dbReference type="GeneID" id="4387362"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01832"/>
    <dbReference type="eggNOG" id="KOG0412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003583_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HD72"/>
    <dbReference type="OMA" id="FHNDAAN"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="13">
        <location>
            <begin position="50"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="12">
        <location>
            <begin position="675"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="150"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="807"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="807"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ93597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1555" mass="170899" checksum="66D56E4378706D7C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDP8</accession>
    <name>Q2HDP8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_01656</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220877.1">
        <property type="nucleotide sequence ID" value="XM_001220876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDP8"/>
    <dbReference type="FunCoup" id="Q2HDP8">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HDP8"/>
    <dbReference type="GeneID" id="4387797"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01656"/>
    <dbReference type="eggNOG" id="KOG0305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014831_6_0_1"/>
    <dbReference type="InParanoid" id="Q2HDP8"/>
    <dbReference type="OMA" id="PVKSHHG"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000098">
        <property type="entry name" value="WD repeat-containing protein slp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="9">
        <location>
            <begin position="278"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="323"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="406"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="537"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="151"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="574"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ93421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="599" mass="64502" checksum="D7322CEF71D3CE2C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDW5</accession>
    <name>Q2HDW5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pH-response regulator protein palC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_01589</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palC family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220810.1">
        <property type="nucleotide sequence ID" value="XM_001220809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDW5"/>
    <dbReference type="STRING" id="306901.Q2HDW5"/>
    <dbReference type="GeneID" id="4386289"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01589"/>
    <dbReference type="eggNOG" id="ENOG502QWTM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023703_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HDW5"/>
    <dbReference type="OMA" id="PNDKEWM"/>
    <dbReference type="OrthoDB" id="10266451at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037505">
        <property type="entry name" value="pH-resp_palC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="318"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ93354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="451" mass="48484" checksum="FAE2D7999E9C1DB2" modified="2006-03-21" version="1">MPYPFVLPTTSSFSFSSSVTCESHPSLPLQASTHRGVVRDTLKKHKRLPPASQAPSLSTVTSTLQTYLPYLFALNASLSGKPIHPDELSVTLKTAPQIEWRPTLSNNLLPGCEPPRVRIHSLEHELLFALSTLANTYTLQARATLQPLYQTTTAPVGTTQRQTAITTATRHLLDAASIYDHLSTRTESPPTATTTTTTKTPPYPCADISPHLLRAQRALALAEATLLAVLKDDPYPAAVAQTRNQHDTEWMYKSPDIPKVRAHLFARLCLAAAKHAAQARGRAGGSGGRGGESQRGLGGETGTGIAWLRAGLGEVGVERKGGEKSGGGGGGGGGSGGLKGLRKEWSERREDKKVEKGLDWGADGGRLEETRVIEMLEAKWVKQNDTMLTQPIPPIGPLLAQMPSGREIHSIKPFQPPLLSAEVLEAMRAPPDRSDEFGNYPSSDEETALAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HED2</accession>
    <name>Q2HED2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_01422</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PGAP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220643.1">
        <property type="nucleotide sequence ID" value="XM_001220642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HED2"/>
    <dbReference type="FunCoup" id="Q2HED2">
        <property type="interactions" value="155"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HED2"/>
    <dbReference type="GeneID" id="4387453"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01422"/>
    <dbReference type="eggNOG" id="KOG2970">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032917_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HED2"/>
    <dbReference type="OMA" id="DFMIEDC"/>
    <dbReference type="OrthoDB" id="419770at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016477858" description="Post-GPI attachment to proteins factor 3" evidence="7">
        <location>
            <begin position="31"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ93187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="335" mass="38457" checksum="5C74ED49C559E796" modified="2006-03-21" version="1">MMVPRGLRRGFPLGSLLFVAFLFLARPVAASIGDQLPEFRECVEICKHENCGPDASHQTSIPLHRRLLLWTCPAECDYTCQQIITTTRQTGTTPSLPVVQFHGKWPFRRVLGMQEPLSVVFSLGNLAAHYYGLHRQVLPRIPAVYSMRPFYVFLARLGMVTWLLSAVFHTRDFRVTERLDYFAAGASVLYGMYYAAVRIWRLDRPGNVRGLRGWTALCAVLYACHVAYLGLWRWDYTYNTLACVVCGVVQNLLWSWFSWMRYRQTGKTWALWPGLVVMWVVAAMSMELFDFPPLWDSVDAHSLWHLGTIPPAVLFYHFLVKDAQDDLARSARLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEV3</accession>
    <name>Q2HEV3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220472.1">
        <property type="nucleotide sequence ID" value="XM_001220471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEV3"/>
    <dbReference type="GeneID" id="4386866"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01251"/>
    <dbReference type="HOGENOM" id="CLU_1038286_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HEV3"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="268" mass="29152" checksum="B86A0FB5E2DCC8F5" modified="2006-03-21" version="1">MTSSSPGDDTRRHLAALPTQPSKNVRTGARANPRPFRGGSCRFRTSAGDLPPYWQFRVGARCCSTPPKRQSVLAVAVTALPEDFSPNHLSRTVPTLVDRSTADIPEPIFADSEERITVVLHRVTCRPFIGRKNQSWSPNPSRDLFSQRQSGGGSRRETPEAHWHVDQPRAGTSSSEPETFCTNIAGYPSLSVIGPPQGFESRKQLTLVHWVRRQGGKLANGAKFSAAKAKSRRVAPSEHESVCSPTGLASLATTKVWVPATCDSGQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEX0</accession>
    <name>Q2HEX0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_01234</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220455.1">
        <property type="nucleotide sequence ID" value="XM_001220454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEX0"/>
    <dbReference type="STRING" id="306901.Q2HEX0"/>
    <dbReference type="GeneID" id="4388306"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01234"/>
    <dbReference type="eggNOG" id="KOG1185">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_1_3_1"/>
    <dbReference type="InParanoid" id="Q2HEX0"/>
    <dbReference type="OMA" id="DFRHEEP"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02002">
        <property type="entry name" value="TPP_BFDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF133">
        <property type="entry name" value="BENZOYLFORMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="7">
        <location>
            <begin position="53"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="5">
        <location>
            <begin position="242"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="6">
        <location>
            <begin position="463"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="652"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ92999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="674" mass="74181" checksum="D09E8F24F721BCE4" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEX4</accession>
    <name>Q2HEX4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_01230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220451.1">
        <property type="nucleotide sequence ID" value="XM_001220450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEX4"/>
    <dbReference type="FunCoup" id="Q2HEX4">
        <property type="interactions" value="659"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HEX4"/>
    <dbReference type="GeneID" id="4388181"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01230"/>
    <dbReference type="eggNOG" id="KOG0271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_16_1"/>
    <dbReference type="InParanoid" id="Q2HEX4"/>
    <dbReference type="OMA" id="AWEPYHR"/>
    <dbReference type="OrthoDB" id="10267436at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110136">
        <property type="term" value="P:protein-RNA complex remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="142"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="185"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="228"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="276"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="400"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="442"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="484"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ92995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="517" mass="57049" checksum="0DC3E2A826F72EA6" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG25</accession>
    <name>Q2HG25_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_00829</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220050.1">
        <property type="nucleotide sequence ID" value="XM_001220049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG25"/>
    <dbReference type="STRING" id="306901.Q2HG25"/>
    <dbReference type="GeneID" id="4387752"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00829"/>
    <dbReference type="eggNOG" id="KOG1667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040079_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HG25"/>
    <dbReference type="OMA" id="KGYTCCK"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1130.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007051">
        <property type="entry name" value="CHORD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039790">
        <property type="entry name" value="CHRD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
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        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983:SF3">
        <property type="entry name" value="CHPADIPLOID STATE MAINTENANCE PROTEIN CHPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983">
        <property type="entry name" value="CYSTEINE AND HISTIDINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04968">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
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        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CHORD" evidence="6">
        <location>
            <begin position="5"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="CHORD" evidence="6">
        <location>
            <begin position="133"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="5">
        <location>
            <begin position="218"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="88"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ92594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="328" mass="35857" checksum="DB22B28078F4694E" modified="2006-03-21" version="1">MAQKCVHQGCGKEYTDPEEVCRYHPGPPVFHEGQKADHGFYGPGWKCCKPRVLTFEEFMTIEPCTEGKHSTTDLPPKVEKREADPALLAASNLPPPPPRAPVAAPQHVPTPPPPPPESEDDDETAEIPDGRMCRRKGCGATYTKGSSREGEACVHHPGAPIFHEGSKGYVCCKRRVLEFDQFMKIEGCKTKNRHLFVGSGSKNATGKGPTGSGGEELLETVRHDFYQTPTAVIASFFLKKIDKEAAKVEFEEQALVLDLPTTDAPVPKRYKTQVPLYGPIDPAKSTFKILGTKLEVSLAKADGSSWPVLRSDDRLTGEILQIGRAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG92</accession>
    <name>Q2HG92_CHAGB</name>
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        <recommendedName>
            <fullName evidence="6">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_00762</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219983.1">
        <property type="nucleotide sequence ID" value="XM_001219982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG92"/>
    <dbReference type="STRING" id="306901.Q2HG92"/>
    <dbReference type="GeneID" id="4386730"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00762"/>
    <dbReference type="eggNOG" id="KOG1703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009967_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HG92"/>
    <dbReference type="OMA" id="CGDPFTP"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031941">
        <property type="term" value="C:filamentous actin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051371">
        <property type="term" value="F:muscle alpha-actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PDZ-LIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214:SF38">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP-RELATED"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="620"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="716"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
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        <location>
            <begin position="196"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="784"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
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        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="399"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="420"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ92527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="837" mass="91317" checksum="24F3153B063DE577" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGN2</accession>
    <name>Q2HGN2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219843.1">
        <property type="nucleotide sequence ID" value="XM_001219842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGN2"/>
    <dbReference type="GeneID" id="4386997"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00622"/>
    <dbReference type="HOGENOM" id="CLU_1510411_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGN2"/>
    <dbReference type="OrthoDB" id="3530944at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="178" mass="18438" checksum="C9D4135F635012B3" modified="2006-03-21" version="1">MHRKRPDAEPRGQPHEDKHADADLGVDVELLLGLGGVLEGDADDGADGAGGQDEHHLEEGGDGQRQTPPARGHGQRREEDHQEGEHGGGEEEAEHDLGGEAQDVEDGDDLRGEGDGGAGEQFVHENLDRVEPVQGGGLGAEGDARADVALAEVPQADLVEVVQADGLGDAVDQASVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH32</accession>
    <name>Q2HH32_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD40 repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_00472</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219693.1">
        <property type="nucleotide sequence ID" value="XM_001219692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH32"/>
    <dbReference type="GeneID" id="4387786"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00472"/>
    <dbReference type="eggNOG" id="ENOG502SH8E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010931_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HH32"/>
    <dbReference type="OMA" id="LYPLPEC"/>
    <dbReference type="OrthoDB" id="5321461at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055525">
        <property type="entry name" value="DUF7099"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055526">
        <property type="entry name" value="DUF7100"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055527">
        <property type="entry name" value="DUF7101"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23388">
        <property type="entry name" value="DUF7099"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23391">
        <property type="entry name" value="DUF7100"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23392">
        <property type="entry name" value="DUF7101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208951" description="WD40 repeat protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7100" evidence="4">
        <location>
            <begin position="7"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7100" evidence="4">
        <location>
            <begin position="232"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7101" evidence="5">
        <location>
            <begin position="375"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7099" evidence="3">
        <location>
            <begin position="664"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ92237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1036" mass="115083" checksum="C795C563B4E2591D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH62</accession>
    <name>Q2HH62_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219663.1">
        <property type="nucleotide sequence ID" value="XM_001219662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH62"/>
    <dbReference type="GeneID" id="4388274"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00442"/>
    <dbReference type="eggNOG" id="ENOG502SSTB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150197_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HH62"/>
    <dbReference type="OMA" id="GWVGYQI"/>
    <dbReference type="OrthoDB" id="4083871at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42077">
        <property type="entry name" value="YALI0F30239P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42077:SF1">
        <property type="entry name" value="YALI0F30239P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ92207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="143" mass="16254" checksum="BB9A4763EBE37F02" modified="2006-03-21" version="1">MAWGKQKLQTPPSTIRSASPRLTELLPPRFWKWPNTSLRQLLPLIITIVVLSVVAWVCYQIYLSFGKIKTQARKQMGENVSFTKDGMRVKVHGIGAESYLDKTQSWVVKAWELGSGSSPNENDEAARRKRNVLTKPKPEEGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HIB5</accession>
    <name>Q2HIB5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_00039</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219260.1">
        <property type="nucleotide sequence ID" value="XM_001219259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HIB5"/>
    <dbReference type="GeneID" id="4388238"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00039"/>
    <dbReference type="eggNOG" id="ENOG502QW20">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011017_4_1_1"/>
    <dbReference type="InParanoid" id="Q2HIB5"/>
    <dbReference type="OMA" id="QEITNIM"/>
    <dbReference type="OrthoDB" id="3037908at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF10">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ91804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="40526" checksum="E8F423407E31F714" modified="2006-03-21" version="1">MATAGRPHPQPKGELTHNSNTPADNPSNPSNPVNPVNPSSVSCAQCRSRKLRVSLYFRNIHGGAPMLHQASYTAGLRLPPHMRPPMCLQYIVMASAAATSETYRHLSEPFYQRSRAYAEVDELRGQETFAAGTTNEPPIPLCKGLQQLEQGQDAQPSPLAIRILAANELLHALDNNPRHFFEVDNGDEIPNGPYWVRHRQIDMNLTTLTMLLPERLHLHRAPRTLDAILVHASTNMATIHLHRTALALLHELQTRSPKDASHQLLIAQGQTRLLPATEGILAVFRAAGDGVGTAIRNPFLSFAAYLAALVFLEDHFREAAGEEGRPREGPLGRSEEKLRYLAQTLVFFGRRARLCGPSRSSWRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM17</accession>
    <name>Q2GM17_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_10987</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226254.1">
        <property type="nucleotide sequence ID" value="XM_001226253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GM17"/>
    <dbReference type="STRING" id="306901.Q2GM17"/>
    <dbReference type="GeneID" id="4397220"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10987"/>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008964_7_0_1"/>
    <dbReference type="InParanoid" id="Q2GM17"/>
    <dbReference type="OMA" id="QSKPWEG"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF149">
        <property type="entry name" value="GTPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DYNAMIN"/>
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</entry>
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</entry>
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</entry>
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            <begin position="18"/>
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        </location>
    </feature>
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    </evidence>
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    </evidence>
    <sequence length="112" mass="11127" checksum="3FC9E2CA713E988F" modified="2006-03-21" version="1">MRPSPFLITLFTGLATAQSIIDTDTDTTTMTSTDVSTETAPGIVITTIMTIEYTTTTMTPSMVVISPTSTSTATTTATVVPVAGANALGAQVPLAGLAAAAAGVAMGMAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNF3</accession>
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    </dbReference>
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        </location>
    </feature>
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        <location>
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            <end position="240"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
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        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ84097.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="62391" checksum="2581BCC4140FA019" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNQ8</accession>
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        <submittedName>
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        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228323.1">
        <property type="nucleotide sequence ID" value="XM_001228322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNQ8"/>
    <dbReference type="STRING" id="306901.Q2GNQ8"/>
    <dbReference type="GeneID" id="4396575"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10396"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009958_6_1_1"/>
    <dbReference type="InParanoid" id="Q2GNQ8"/>
    <dbReference type="OMA" id="IYKHTME"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF82">
        <property type="entry name" value="FAMILY CHAPERONE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G08575)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ83992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="674" mass="74605" checksum="EF511BC04C24AC29" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPB8</accession>
    <name>Q2GPB8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Actin-related protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Actin-like protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_10186</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228113.1">
        <property type="nucleotide sequence ID" value="XM_001228112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPB8"/>
    <dbReference type="FunCoup" id="Q2GPB8">
        <property type="interactions" value="668"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GPB8"/>
    <dbReference type="GeneID" id="4396258"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10186"/>
    <dbReference type="eggNOG" id="KOG0678">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_3_0_1"/>
    <dbReference type="InParanoid" id="Q2GPB8"/>
    <dbReference type="OMA" id="GIHYPIR"/>
    <dbReference type="OrthoDB" id="421448at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10221">
        <property type="entry name" value="ASKHA_NBD_Arp3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000029">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000006">
        <property type="entry name" value="Actin-related protein 3 (ARP3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ83782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="438" mass="47698" checksum="2DCF08DEFFB2E80A" modified="2006-03-21" version="1">MANQTPAVVMDNGTGFSKLGFAGNDSPSFVFPTAIATKGAATGGGAGSGRPPVPNRPSFLTGGAGPTGHLSGKRGTEDLDFFIGDEAISAAGGPGYGLHYPIRHGQIENWDHMERFWSNSIFKYLRVEPEDHYFLLTEPPLNPPENRENTAEIFFESFNCAGLYIAVQAVLALAASWTSSKVTDRSLTGTVIDSGDGVTHVIPVAEGYVIGSSIKSIPIAGRDITYFVQSLLRDRGEPDSSLKTAQEIKEEYCYVCPDIVNEFGKYDRDRTRFLKHVVAHPGGRQVSVDVGYERFLAPEIFFNPEIYSSDFLTPLPVVVDGVIQSSPIDVRRGLYKNIVLSGGSTLYKDFGRRLQRDIKQLVDARIRQSEVRSGGAKSGGLEVQVIGHKRQRHGPWFGGSLLGQTPEFRSYCHTKAEYQEYGPGIVRRFALLGGPGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPI0</accession>
    <name>Q2GPI0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228051.1">
        <property type="nucleotide sequence ID" value="XM_001228050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPI0"/>
    <dbReference type="GeneID" id="4396850"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10124"/>
    <dbReference type="HOGENOM" id="CLU_1992373_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPI0"/>
    <dbReference type="OrthoDB" id="10428495at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ83720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="125" mass="13608" checksum="1B4E6ED7234CABE1" modified="2006-03-21" version="1">MLEDVTIMVACSRLAGYAGSTPSQSLSKKDGQWDVRPIAQEGPCQGNEQVLILLIKGVVSTLSTLKWIVYSHSFWGALGVLQLAITTTVRYKLGSRLLRQAFVVHLLAAPNLSTLERLPSTEAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPN2</accession>
    <name>Q2GPN2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227999.1">
        <property type="nucleotide sequence ID" value="XM_001227998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPN2"/>
    <dbReference type="GeneID" id="4396623"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10072"/>
    <dbReference type="eggNOG" id="ENOG502T3HY">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="Proteomes" id="UP000001056">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ83668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="13982" checksum="27C50AC24988E090" modified="2006-03-21" version="1">MEKCDCVYKVGASTKCTIGEFDKLRPDCVTKESRYMDMDGTGVAVESDEFMFISEDLDVPFARLGDSGSIVWDTHGNAVGLLFRGQRPNQTRGWCVYVTPIEDVFESIKAKSGNKIQEIRFLGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQK3</accession>
    <name>Q2GQK3_CHAGB</name>
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        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">CHGG_09751</name>
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227678.1">
        <property type="nucleotide sequence ID" value="XM_001227677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQK3"/>
    <dbReference type="STRING" id="306901.Q2GQK3"/>
    <dbReference type="GeneID" id="4396956"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09751"/>
    <dbReference type="eggNOG" id="ENOG502S5NQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081911_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQK3"/>
    <dbReference type="OMA" id="CFALGIM"/>
    <dbReference type="OrthoDB" id="4918558at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23335" checksum="761D7D6BD6043F8E" modified="2006-03-21" version="1">MLFGIMFAFWRFLEIVTLIPIMGMLAWFVNIHLEANVMTPAYILVLFIVSVLALAWAIFTLFSYHRSSANAQFVGVIDLAFVGALIAGVYYLRFIARADCVSVQPGSSVDLDFGILGSVGFTGVDVAASKTCSMLKACFALGIMNTVFFFVTAVMAWIHGDHAVKSEKRYVETRRRSHSRGHSHSRHRSHSGHRHGSRRSSHSHHRAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQL6</accession>
    <name>Q2GQL6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227665.1">
        <property type="nucleotide sequence ID" value="XM_001227664.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4396898"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09738"/>
    <dbReference type="eggNOG" id="KOG2029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001668_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GQL6"/>
    <dbReference type="OMA" id="RTTESHD"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48187">
        <property type="entry name" value="LD21810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48187:SF2">
        <property type="entry name" value="LD21810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="874"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1132"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1225"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1582"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1634"/>
            <end position="1678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1169"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1271"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1378"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1415"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1443"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1472"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1495"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1585"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1643"/>
            <end position="1658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1678" mass="183155" checksum="83EF175B2717277A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRF8</accession>
    <name>Q2GRF8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_09446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227373.1">
        <property type="nucleotide sequence ID" value="XM_001227372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRF8"/>
    <dbReference type="GeneID" id="4395551"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09446"/>
    <dbReference type="eggNOG" id="ENOG502RJ1Y">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2320114_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRF8"/>
    <dbReference type="OrthoDB" id="4580930at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ85432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="99" mass="10489" checksum="563693CDE347795D" modified="2006-03-21" version="1">MRVSTAPLFRTSLRPAFGQAHCIRPIQSRLATTSSGAGPEREVGHKGTAKEYNKDGTNPNKNVMYAGLAALGLGGVYAMFMARPEKVGEKAKANSPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRQ4</accession>
    <name>Q2GRQ4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_09350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227277.1">
        <property type="nucleotide sequence ID" value="XM_001227276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRQ4"/>
    <dbReference type="GeneID" id="4395563"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09350"/>
    <dbReference type="HOGENOM" id="CLU_765042_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRQ4"/>
    <dbReference type="OMA" id="GVECANR"/>
    <dbReference type="OrthoDB" id="4810403at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208536" evidence="2">
        <location>
            <begin position="21"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ85336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="362" mass="39483" checksum="DDA471A5AC8C9DA9" modified="2006-03-21" version="1">MHPKLHSIATSLLLATQAQAFRVTFYLGSQCRGARLGTGSYSYPGYPNACHNVPPNAISATIEPEYLDGESNNVAFWKSCSQDLIASGDDNCLNFPKATRFSIREDWTVPGKRSVPSAATTSTTESEKAIAPLAQKTRARGRSRTAAHAPWAAEQARHRQRLNVSEAAALGSLSPYFDPAIMAEGGFGHGNVSEAFGDTVRWQQVALGISVGVPIHEWDDAVHVKSDAFVPYGDVHSRGLEARDDGCGGAAAPDEEGVCHSHWALAERSEHEKRWDYARCRSLLTCVRDTVGGAPLRLADGWAQGVECANRIKAAGSTLYDYVKRYPVTCEVVKLGAGGRDRLRVRSDRFRWRVLRLKTPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRT3</accession>
    <name>Q2GRT3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_09321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227248.1">
        <property type="nucleotide sequence ID" value="XM_001227247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRT3"/>
    <dbReference type="STRING" id="306901.Q2GRT3"/>
    <dbReference type="GeneID" id="4395013"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09321"/>
    <dbReference type="eggNOG" id="KOG0593">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017513_4_1_1"/>
    <dbReference type="InParanoid" id="Q2GRT3"/>
    <dbReference type="OMA" id="QWIFLAP"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359:SF1">
        <property type="entry name" value="INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE EPSILON SUBUNIT HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="156"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ85307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="550" mass="63079" checksum="E6D6E388B5B6C6C3" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRX6</accession>
    <name>Q2GRX6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227205.1">
        <property type="nucleotide sequence ID" value="XM_001227204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRX6"/>
    <dbReference type="GeneID" id="4395253"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09278"/>
    <dbReference type="HOGENOM" id="CLU_1594333_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRX6"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="167" mass="17972" checksum="C6F72DBD110A917B" modified="2006-03-21" version="1">MGAVLCGVSSSEERRSSSHRSGGGGGGRRGGNNSRFADLDDRQSRRSAPRRWERGNIARNYARLDDRTIGERSRGAIPGTTTTENNVNIAKIAWLSRKDTSKAYGSIVVYVTKVKMASSSAFNNYIVDSAMGPTCSRQVPPGSFGVPAARGHGHSCRWAVPSPAFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSA8</accession>
    <name>Q2GSA8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor PAP1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_09146</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227073.1">
        <property type="nucleotide sequence ID" value="XM_001227072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSA8"/>
    <dbReference type="STRING" id="306901.Q2GSA8"/>
    <dbReference type="GeneID" id="4395768"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09146"/>
    <dbReference type="eggNOG" id="ENOG502RPD7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011807_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSA8"/>
    <dbReference type="OMA" id="LNMACGN"/>
    <dbReference type="OrthoDB" id="5380163at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.100">
        <property type="entry name" value="YAP1 redox domain. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013910">
        <property type="entry name" value="TF_PAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023167">
        <property type="entry name" value="Yap1_redox_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08601">
        <property type="entry name" value="PAP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111430">
        <property type="entry name" value="YAP1 redox domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor PAP1" evidence="4">
        <location>
            <begin position="236"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor PAP1" evidence="4">
        <location>
            <begin position="359"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="26"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="215"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ85132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="513" mass="55454" checksum="D6891191E6F03E01" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSH5</accession>
    <name>Q2GSH5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA repair metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227006.1">
        <property type="nucleotide sequence ID" value="XM_001227005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSH5"/>
    <dbReference type="STRING" id="306901.Q2GSH5"/>
    <dbReference type="GeneID" id="4395637"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09079"/>
    <dbReference type="eggNOG" id="KOG1361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013294_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GSH5"/>
    <dbReference type="OMA" id="CTENAQQ"/>
    <dbReference type="OrthoDB" id="5561659at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="42127" checksum="9AC26580078FCC2B" modified="2006-03-21" version="1">MSMFRFLMGSHSDNKFSPSSHLTPEAPALVGFMCGNTHHPGCLTSDETVRLHSCEKGNYCATVKNNSVVWIQPIITRLPDGEDVAEVGVGGGGDDLEREAELDYLSPDDVASLLEAAIVNGRKVPLGLEGAAFWENNEVDLIRGLQAIARKLGLRERPLGNRAKTLPNIVTFPYSRHASYPELCHLVETLKPRDIWPCTVDVPRWLREEITVGRLFAPYCSGVTFRHDDAMRERFGHYTNNANPSLESQITVSSASHDTRFSQDSVNDPASDHHSQPLSLPTQEYHPGSAASPELGVQADEVEAHEPQAWDLEMAEPIDELAALDSFHPTGLIDSQNSTISELALETRLQAFQALLKKAQGKAGAEIGLMSTTDNHSKLEEELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSH9</accession>
    <name>Q2GSH9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227002.1">
        <property type="nucleotide sequence ID" value="XM_001227001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSH9"/>
    <dbReference type="GeneID" id="4395139"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09075"/>
    <dbReference type="HOGENOM" id="CLU_2885581_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSH9"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="63" mass="6605" checksum="820278EAA7CE3F67" modified="2006-03-21" version="1">MPDLKALHACRNVGVASHAGQGAIKRQARNLNQTPSQTPHSQEGRSCRSAPSSGQFSPNPGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSJ4</accession>
    <name>Q2GSJ4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="9">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_09060</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="9"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226987.1">
        <property type="nucleotide sequence ID" value="XM_001226986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSJ4"/>
    <dbReference type="FunCoup" id="Q2GSJ4">
        <property type="interactions" value="838"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GSJ4"/>
    <dbReference type="GeneID" id="4395921"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09060"/>
    <dbReference type="eggNOG" id="KOG0347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_299349_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSJ4"/>
    <dbReference type="OMA" id="CEREYAR"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17946">
        <property type="entry name" value="DEADc_DDX24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="782"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="229"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="392"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="86"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="973"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ85046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1002" mass="109068" checksum="4455F3CF0FBA5531" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSV4</accession>
    <name>Q2GSV4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226877.1">
        <property type="nucleotide sequence ID" value="XM_001226876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSV4"/>
    <dbReference type="GeneID" id="4394701"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08950"/>
    <dbReference type="HOGENOM" id="CLU_2014998_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSV4"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="123" mass="14475" checksum="11D31160ABF18009" modified="2006-03-21" version="1">MHSDPRIKGSDVGEFQPFRFLLATISQHKKHNPEQQQQHRPAMSTGTPTITPLPSALSRRKTPLPRPPLRQLLIQAFVALLVTRLISPLLYYYDDYYYYYYRQNYYFLRQGRLQCPGKEDGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSZ0</accession>
    <name>Q2GSZ0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Lactoylglutathione lyase</fullName>
            <ecNumber evidence="3 9">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_08914</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-S-lactoylglutathione = methylglyoxal + glutathione</text>
            <dbReference type="Rhea" id="RHEA:19069"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:57474"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="4.4.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glyoxalase I family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="3 9"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226841.1">
        <property type="nucleotide sequence ID" value="XM_001226840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSZ0"/>
    <dbReference type="FunCoup" id="Q2GSZ0">
        <property type="interactions" value="194"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GSZ0"/>
    <dbReference type="GeneID" id="4395478"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08914"/>
    <dbReference type="eggNOG" id="KOG2944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GSZ0"/>
    <dbReference type="OMA" id="MGDAWGH"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF30">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00935">
        <property type="entry name" value="GLYOXALASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="VOC" evidence="10">
        <location>
            <begin position="11"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="10">
        <location>
            <begin position="170"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ84900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="321" mass="36684" checksum="A71BE89F18D626A3" modified="2006-03-21" version="1">MASTTETKNYKFNHTMLRVKDPKESVKFYSFLGMSQVKKLEFPEAKFDLYFLGYDSPKAASGGNNVWDREGLIELTHNYGTENDAEYKVNNGNVEPHRGFGHTCISVDNIQAACQRIEEAGYKFQKKLTDGRMRHIAFALDPDGYWVEIIGQKPVEETENVKETDVETYRMNHTMLRVKDAEKSLKFYQEALGMSLFRKHEAQAAGFNLYFLGYPGEKGAPIEGQSTADREGLLELTWNYGTEKDENFKYHDGNSQPQGFGHICVSVDNLDAACARLESLNVNWKKRLTDGRMKNVAFVLDPDGYWVEIVQNERFADKANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GT09</accession>
    <name>Q2GT09_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Autophagy-related protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_08895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ATG13 family. Fungi subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226822.1">
        <property type="nucleotide sequence ID" value="XM_001226821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GT09"/>
    <dbReference type="FunCoup" id="Q2GT09">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GT09"/>
    <dbReference type="GeneID" id="4395287"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08895"/>
    <dbReference type="eggNOG" id="KOG4573">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007151_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GT09"/>
    <dbReference type="OMA" id="FHQVGPT"/>
    <dbReference type="OrthoDB" id="70161at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040182">
        <property type="entry name" value="ATG13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018731">
        <property type="entry name" value="Atg13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10033">
        <property type="entry name" value="ATG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 13 N-terminal" evidence="6">
        <location>
            <begin position="67"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="348"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="409"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="603"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="833"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="411"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="522"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="624"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="647"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="663"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="707"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="739"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="754"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ84881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="860" mass="93419" checksum="2937379AD85250E4" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTF7</accession>
    <name>Q2GTF7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_08747</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226674.1">
        <property type="nucleotide sequence ID" value="XM_001226673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTF7"/>
    <dbReference type="GeneID" id="4395573"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08747"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="InParanoid" id="Q2GTF7"/>
    <dbReference type="OMA" id="FGCSYIE"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF35">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ84733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="44583" checksum="8EE11C1EB9AC3F0A" modified="2006-03-21" version="1">MYEASNVYFICGFAAIGGGLFGFDISSMSGVLGTQAYKRYFNNPVSYAQGGITASMPAGSLVGSLASSFIADKYSLICGLCVGIASSIVPVYQSEIAPKEIRGRVVSLQQWAITWGILIQYFIQFGAAEGTGGGSKDPNQPTAAFRIPWGVQMVPAFILLVGLFFFPYSPRWLASKDRMDEALRVLARLHGKGDVNHPKVLAQYQEIEEALQLEREQATSSFRDLVAPRMYKRVLLGMSIQMWSQLCGMNIMMYYIVYIMEGAQIASPLATASIHKIRAKAVSLSTATNWFWNMVLAFGVPPLLWNISYKMYYIFGAFNAAAFVHMTLMAPETKGFTLEEMDDVFNSGLPAWKRYKKASRLEELEREIEAGNLKVAVPVGGQTTAASTAPQATESEKKAEPTTTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTN9</accession>
    <name>Q2GTN9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-demethoxyubiquinone hydroxylase, mitochondrial</fullName>
            <shortName evidence="8">DMQ hydroxylase</shortName>
            <ecNumber evidence="8">1.14.99.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ubiquinone biosynthesis monooxygenase COQ7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">COQ7</name>
        <name evidence="10" type="ORF">CHGG_08665</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + AH2 + O2 = a 3-demethylubiquinol + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50908"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="1.14.99.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="8">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the COQ7 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.60" evidence="8"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226592.1">
        <property type="nucleotide sequence ID" value="XM_001226591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTN9"/>
    <dbReference type="FunCoup" id="Q2GTN9">
        <property type="interactions" value="309"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GTN9"/>
    <dbReference type="GeneID" id="4395486"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08665"/>
    <dbReference type="eggNOG" id="KOG4061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071892_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTN9"/>
    <dbReference type="OMA" id="WSTAVMG"/>
    <dbReference type="OrthoDB" id="275371at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160224">
        <property type="term" value="F:3-demethoxyubiquinone 3-hydroxylase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01658">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="21"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ84651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="260" mass="28619" checksum="D3B9F354596BFD6B" modified="2006-03-21" version="1">MASPRLLWQPMRHCMSRILAPARQQTRSISSTTTSASQATTSSSSSPSNTNTNTNTTSQPNPTPPPKPKKPLTPAQQAFLSSALRVNQAGELAATLIYTAQTPPVVAREPHLRPLMRHMYEQEAGHLATFNALIAKHRVRPTALYPVWSALATGLGWTTGVLGREAAMACTEAVETEIGGHYNAQIRRLLEMVAGWEAEGYEVGEELRELIGTLRRIRDEELEHLDHAVEHDAKKAEPYWLLTGVIRAGCRGAIWVSERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTT9</accession>
    <name>Q2GTT9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226542.1">
        <property type="nucleotide sequence ID" value="XM_001226541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTT9"/>
    <dbReference type="GeneID" id="4395847"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08615"/>
    <dbReference type="eggNOG" id="ENOG502QU7D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027354_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTT9"/>
    <dbReference type="OMA" id="HQIRISN"/>
    <dbReference type="OrthoDB" id="4564303at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="631"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="670" mass="75074" checksum="5DFB6A8704DAFA17" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUT0</accession>
    <name>Q2GUT0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_08274</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ87021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225930.1">
        <property type="nucleotide sequence ID" value="XM_001225929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUT0"/>
    <dbReference type="GeneID" id="4394506"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08274"/>
    <dbReference type="eggNOG" id="ENOG502SJS0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031730_4_2_1"/>
    <dbReference type="InParanoid" id="Q2GUT0"/>
    <dbReference type="OMA" id="EHIALHM"/>
    <dbReference type="OrthoDB" id="5271017at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209033" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="17"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="17"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ87021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="230" mass="24399" checksum="4C8F4F18D748AD5F" modified="2006-03-21" version="1">MQLITGLLLAATAVQAHYTFPRLVVNGKSEDKDWSATRMTKNAQSKQGVQNPTSGDIRCYSSQTASNVMTVPAGATVSYISTQQINHPGPTQYYLAKVPAGSSAKTFDGSGAVWFKIATTMPTTDNNKQLVWPGQNTYETTKATIPANTPSGEYLLRVEQIALHMASQPNQAQFYLACSQIQITGGGNGTPGPLVALPGAYSSNDPGILVNIYSIAPDSYKPPGPAVWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUX3</accession>
    <name>Q2GUX3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxin 22-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225887.1">
        <property type="nucleotide sequence ID" value="XM_001225886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUX3"/>
    <dbReference type="STRING" id="306901.Q2GUX3"/>
    <dbReference type="GeneID" id="4393681"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08231"/>
    <dbReference type="eggNOG" id="ENOG502SHU3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025740_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUX3"/>
    <dbReference type="OMA" id="VAAWIWS"/>
    <dbReference type="OrthoDB" id="5327700at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ86978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="41272" checksum="9C0C0CC631B71B6C" modified="2006-03-21" version="1">MSPPYESSRRRGVWNHWVPLAVTVTVATAGVAAWIWSLRKDEDNQETEQPADLQDLDYDNADYGDNPAYGASRDGGAGGTGPKTPTFGGVQPQPESSSSGWAALRRSPSPQQFFDNARRTVAAGVTAAGAVVGSALAAIREEDKSAYADHETWSEEADAKQDRAAAPSQSKDVNKRRKKVAIVISADNRLDDIDADGFHEHASILSHIPRQLDFSAIKLYVLIYAPNLKDSNPDATSALPPPSLSSSFSNIEHAQAQASEEARSPLIGQLIVSFTSPNGHSHILRHMQPEIIYLQESLSGDNGSTVTNMQTWLRHDVILVVGAESGHGGLADSESEAEKPGKEKEVWWHREDRIGRGRGVVVVDGTRVQDDWARRVLGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVC0</accession>
    <name>Q2GVC0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_08084</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001225739.1"/>
    </dbReference>
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        <property type="interactions" value="235"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GVC0"/>
    <dbReference type="GeneID" id="4394553"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08084"/>
    <dbReference type="eggNOG" id="KOG2286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011776_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GVC0"/>
    <dbReference type="OMA" id="MNIGPKT"/>
    <dbReference type="OrthoDB" id="190098at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Exocyst complex component Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ86831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="723" mass="84209" checksum="78B377B89FAE9DD2" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVH6</accession>
    <name>Q2GVH6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_08028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225684.1">
        <property type="nucleotide sequence ID" value="XM_001225683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVH6"/>
    <dbReference type="GeneID" id="4393425"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08028"/>
    <dbReference type="eggNOG" id="ENOG502SWX9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_885661_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GVH6"/>
    <dbReference type="OrthoDB" id="5153884at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ86775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="314" mass="33215" checksum="A027A9168F13E7CB" modified="2006-03-21" version="1">MGGIVDVVVVGEPDGKTGVPLEYSGIGEGGAVATLERRVIWVGGGLTLCTGLKTAVVGSPTLTVTGHQSMAVVVMAGMEMVVVMVWVSPPAADDSSVVVSGGHEMVVVEPSCDGGSTSVHGGMHEAVAPPPGAQMLVGTPVLVGESQDARAAALPEYRRILDAFAASSVHLAAPLTHQAFPKTRTFLNLWPNSVWQCLELTCFHVPPGALERQLFEHAFGAFERMTEPSVLAGIPVACTVDATGGWQPEPDENSGCQVFTGVLFWNSPAARAEWYEELFRLSCESYELFGQKLDALKILAAEGVVTRFLELQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GW75</accession>
    <name>Q2GW75_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Hypercellular protein HypA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_07779</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225435.1">
        <property type="nucleotide sequence ID" value="XM_001225434.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2GW75">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GW75"/>
    <dbReference type="GeneID" id="4393697"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07779"/>
    <dbReference type="eggNOG" id="KOG1953">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002231_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GW75"/>
    <dbReference type="OMA" id="EHSRDRM"/>
    <dbReference type="OrthoDB" id="27962at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058565">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058567">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058568">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058564">
        <property type="entry name" value="TPR_TRAPPC9_Trs120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058563">
        <property type="entry name" value="Trs120_TRAPPC9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26254">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26280">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26282">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26283">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26251">
        <property type="entry name" value="TPR_TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08626">
        <property type="entry name" value="TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 TPR region" evidence="5">
        <location>
            <begin position="448"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 first Ig-like" evidence="6">
        <location>
            <begin position="799"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 third Ig-like" evidence="7">
        <location>
            <begin position="1065"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 fourth Ig-like" evidence="8">
        <location>
            <begin position="1275"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="231"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF26283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ86526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1442" mass="157655" checksum="F8CC37BC35060B1C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWE1</accession>
    <name>Q2GWE1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_07713</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamate + NADP(+) + H2O = 2-oxoglutarate + NH4(+) + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11612"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.4.1.4"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 11">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225369.1">
        <property type="nucleotide sequence ID" value="XM_001225368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWE1"/>
    <dbReference type="FunCoup" id="Q2GWE1">
        <property type="interactions" value="681"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GWE1"/>
    <dbReference type="GeneID" id="4393141"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07713"/>
    <dbReference type="eggNOG" id="KOG2250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025763_2_1_1"/>
    <dbReference type="InParanoid" id="Q2GWE1"/>
    <dbReference type="OMA" id="PCFAAFP"/>
    <dbReference type="OrthoDB" id="6718861at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004354">
        <property type="term" value="F:glutamate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.285.10:FF:000001">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.285.10:FF:000003">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000002">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000030">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.285.10">
        <property type="entry name" value="Glutamate Dehydrogenase, chain A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050724">
        <property type="entry name" value="Glu_Leu_Phe_Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006929">
        <property type="entry name" value="PRK09414.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571:SF1">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="12">
        <location>
            <begin position="190"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="10">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ86460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="451" mass="48987" checksum="98398FC5A4A5F7D4" modified="2006-03-21" version="1">MSHLASEPEFEQAYKELVLTLENSSLFQKNPEYRTALKVVSIPERVIQFRVVWEDDAGNLQANRGYRVQFNSALGPYKGGLRLHPSVNLSILKFLGFEQIFKNALTGLMMGGGKGGADFDPKGKSDAEIRRFCVAFMRELSRHIGADTDVPAGDIGVSGREIGYMFGAYRRERNKFEGVLTGKGLDWGGSLIRPEATGYGLVYYVTHMLELAGVGNWEGKRVAISGSGNVAQYAALKCIELGATIVSLSDSKGSLVAVGDGHVTVEDIESIMDLKVKRQSLSSYTTKGNLQYIEGVRPWLHVGQVDVALPCATQNEVSKEEAEGLVAAGARFVAEGSNMGCTLEAIEVFENERRAKKGNAIWYAPGKAANCGGVAVSGLEMSQNSQRLAWTKEEVDQKLKDIMKNAFDLGVATAKNYVESSEGELPSLVAGSNIAGFVKVAQAMHEHGDWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWY1</accession>
    <name>Q2GWY1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225179.1">
        <property type="nucleotide sequence ID" value="XM_001225178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWY1"/>
    <dbReference type="FunCoup" id="Q2GWY1">
        <property type="interactions" value="1244"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GWY1"/>
    <dbReference type="MEROPS" id="I51.001"/>
    <dbReference type="GeneID" id="4394311"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07523"/>
    <dbReference type="eggNOG" id="KOG3346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1277497_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWY1"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030162">
        <property type="term" value="P:regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF148">
        <property type="entry name" value="CARBOXYPEPTIDASE Y INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208695" evidence="1">
        <location>
            <begin position="20"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="216" mass="23308" checksum="51D15D5200C9C617" modified="2006-03-21" version="1">MIRYSLLFVTLGLFSLGDAQEHPQQHVLGDEVVAGPNPLPQAAELVRDKLKAAEIIPTVIDDFLPSLGLHATWPSGSRAQLGNTLAPANLDSEPSIALHDMRAATGPSPPNKNKNKNKKKTITYAITLTDPDAPTREDPSWSEFCHWIAAGVLEPALCDPRDPGPCAPVLSHLREIVPYKAPAPPRGTGFHRDQQGAVDRVCKIAGHMFATQPSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX00</accession>
    <name>Q2GX00_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_07504</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225160.1">
        <property type="nucleotide sequence ID" value="XM_001225159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX00"/>
    <dbReference type="STRING" id="306901.Q2GX00"/>
    <dbReference type="GeneID" id="4394394"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07504"/>
    <dbReference type="eggNOG" id="ENOG502SWM0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063084_6_1_1"/>
    <dbReference type="InParanoid" id="Q2GX00"/>
    <dbReference type="OMA" id="TCGVPCI"/>
    <dbReference type="OrthoDB" id="3767534at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208539" description="CFEM domain-containing protein" evidence="10">
        <location>
            <begin position="18"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="11">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ86251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="97" mass="9717" checksum="DD3198D3552F341A" modified="2006-03-21" version="1">MQLSTLVIATLAAVASASPAVRRQAECPEVDNIPVCGYSCILAAVTEIGCGTEDYACMCGKFSDLQLAAASCVITNCGLDGAPAVLDAAQAVCDACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX18</accession>
    <name>Q2GX18_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">GAR transformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_07486</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GART family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225142.1">
        <property type="nucleotide sequence ID" value="XM_001225141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX18"/>
    <dbReference type="FunCoup" id="Q2GX18">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GX18"/>
    <dbReference type="GeneID" id="4394573"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07486"/>
    <dbReference type="eggNOG" id="KOG3076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038395_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GX18"/>
    <dbReference type="OMA" id="HYVDEGM"/>
    <dbReference type="OrthoDB" id="5575075at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.170:FF:000009">
        <property type="entry name" value="Phosphoribosylglycinamide formyltransferase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369:SF2">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ86233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="226" mass="25135" checksum="704822120C7510EC" modified="2006-03-21" version="1">MADPCRILVMASGNGSNFQALIDAVTAGRIPDSKIVRLIVNRGKAYATTRADLAGIPWEYFNLISHGFQAKAEKDQQKIQESRDRYDAALAEKLLQGDFKPDLVVLAGWMYVFGKQFLDPIEAAGIKVINLHPALPGKYDGAGAIERAFNDFKEGKLENNKTGIMVHYVIDKVDRGEPILVKEIECRAGEELHQLEERIHAQEHELIVEAAAKVARELVAQKNKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX75</accession>
    <name>Q2GX75_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="6">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_07429</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 8">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225085.1">
        <property type="nucleotide sequence ID" value="XM_001225084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX75"/>
    <dbReference type="FunCoup" id="Q2GX75">
        <property type="interactions" value="725"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GX75"/>
    <dbReference type="GeneID" id="4394060"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07429"/>
    <dbReference type="eggNOG" id="KOG1255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052104_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GX75"/>
    <dbReference type="OMA" id="VIICITE"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000005">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="9">
        <location>
            <begin position="38"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6 7">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="51"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="130"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ86176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="333" mass="34597" checksum="72CAB99832A4B107" modified="2006-03-21" version="1">MQAFSRQSRPAGALLRQLAQRNYSSSASPYAATIQNLRINGDTKVLYQGFTGKQGTFHAQQAIDYGTKVVGGTNPKKAGQTHLGLPVFANVSDAVKETGANATAIFVPPPLAAAGIEEAIAAEVPLVVCITEGIPQHDMVRITSMLKSQSKTRLVGPNCPGIIAPGQCKIGIMPGFIHKRGRIGIVSRSGTLTYEAVNQTTHAGLGQSLVVGIGGDPFSGTNFIDCLKVFLEDPETDGIIMIGEIGGSAEEDAADFIRENNTANGGKPVVSFIAGISAPPGRRMGHAGAIVSGGKGGADSKIKALEAAGVIVERSPAGLGKALRDEFVRRDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXB9</accession>
    <name>Q2GXB9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_07385</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="7">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="7"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225041.1">
        <property type="nucleotide sequence ID" value="XM_001225040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXB9"/>
    <dbReference type="FunCoup" id="Q2GXB9">
        <property type="interactions" value="538"/>
    </dbReference>
    <dbReference type="GeneID" id="4394597"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07385"/>
    <dbReference type="eggNOG" id="KOG3870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030117_2_1_1"/>
    <dbReference type="InParanoid" id="Q2GXB9"/>
    <dbReference type="OMA" id="IFARQKM"/>
    <dbReference type="OrthoDB" id="541375at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097023">
        <property type="term" value="F:fructose 6-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103026">
        <property type="term" value="F:fructose-1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF6">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="8">
        <location>
            <begin position="21"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ86132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="447" mass="49454" checksum="D4E7768646C3312B" modified="2006-03-21" version="1">MDLDPKLAIDDAYRTVGSCDAGEKQEEGKKIVAELAALKYEVQHDRALTPIRDDGHPDVAGYNKELEQLGKITWHNAPWLFTECYLFRRISTSFALSTHWKSYDVFARQKIKTFRSSRPAVLELAARYKDLVTQLRSQAPHDPEADALLFAEMCEVCLWGNATDLSLLTSLTYEDIQKLQGSEARRAAEKNILVNDLPQVFAHLRAAKKDKPAGAQRRVDIVLDNAGFELYVDLVLAGYLLSAGLATTVVLHPKSIPWFVSDVLPADFASLLTALADPRAFYETPTEEDTLQGVEPPRLSEAEVEELGFLFAEWSRFHAEGQLVLRPNRVWTGPGSFWRLPGEAEGLVEDLREGELVVFKGDLNYRKLVGDVAWDPTTPFADAIGPLGPGSGLNVLALRTCKADVVVGLKPGEDEKLKAMEDGGGESGARKWAWNGKWAVVSFSKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXJ0</accession>
    <name>Q2GXJ0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_07314</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224970.1">
        <property type="nucleotide sequence ID" value="XM_001224969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXJ0"/>
    <dbReference type="STRING" id="306901.Q2GXJ0"/>
    <dbReference type="GeneID" id="4394068"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07314"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GXJ0"/>
    <dbReference type="OMA" id="EFHSCDV"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF12">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_1G14540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ86061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="283" mass="28983" checksum="D836202155FC6031" modified="2006-03-21" version="1">MAEAQLHDFPSLFSLEGKVAVVTGGSRGLGLSAASALLQAGASKVFISSRKAAACDAACATLNALPNLRPGARAISVPADGATLEGVKHLVSQVAAQTEHVDILLANAGATWGEGFDTHSDAAFAKVLDLNVRGVFNAVREFAPLLQRRARAADPSRVVITASVAGLGVGTLGKQGTYGYSASKAAVLHLGRNLAVELGPRAITVNSICPGFFPSKMSNGLLEMSGGAEALGKENPLRRLGQAEDIAGVIVYLTSRAGAYVNGAAIEIDGGALWQKGQLDVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXL0</accession>
    <name>Q2GXL0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_07294</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2005-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Giovannoni S.J."/>
                <person name="Cho J.-C."/>
                <person name="Ferriera S."/>
                <person name="Johnson J."/>
                <person name="Kravitz S."/>
                <person name="Halpern A."/>
                <person name="Remington K."/>
                <person name="Beeson K."/>
                <person name="Tran B."/>
                <person name="Rogers Y.-H."/>
                <person name="Friedman R."/>
                <person name="Venter J.C."/>
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        <citation type="submission" date="2006-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="Birren B."/>
                <person name="Lander E."/>
                <person name="Galagan J."/>
                <person name="Devon K."/>
                <person name="Nusbaum C."/>
                <person name="Ma L.-J."/>
                <person name="Jaffe D."/>
                <person name="Butler J."/>
                <person name="Alvarez P."/>
                <person name="Gnerre S."/>
                <person name="Grabherr M."/>
                <person name="Kleber M."/>
                <person name="Mauceli E."/>
                <person name="Brockman W."/>
                <person name="Rounsley S."/>
                <person name="Young S."/>
                <person name="LaButti K."/>
                <person name="Pushparaj V."/>
                <person name="DeCaprio D."/>
                <person name="Crawford M."/>
                <person name="Koehrsen M."/>
                <person name="Engels R."/>
                <person name="Montgomery P."/>
                <person name="Pearson M."/>
                <person name="Howarth C."/>
                <person name="Kodira C."/>
                <person name="Yandava C."/>
                <person name="Zeng Q."/>
                <person name="Alvarado L."/>
                <person name="Oleary S."/>
                <person name="Untereiner W."/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="730" mass="80350" checksum="0AF8B1A1F0C32FF8" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYY0</accession>
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        <recommendedName>
            <fullName evidence="6">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomium</taxon>
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    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="nucleotide sequence ID" value="XM_001224479.1"/>
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    <dbReference type="HOGENOM" id="CLU_267261_0_0_1"/>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0003676">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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            <end position="1235"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1134"/>
            <end position="1171"/>
        </location>
    </feature>
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        <location>
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            <end position="157"/>
        </location>
    </feature>
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        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1158"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ85571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1235" mass="138158" checksum="7D0BC10DE8CD4C73" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZH3</accession>
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        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
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        <name evidence="8" type="ORF">CHGG_05073</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88454.1"/>
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        <property type="nucleotide sequence ID" value="XM_001224286.1"/>
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    <dbReference type="STRING" id="306901.Q2GZH3"/>
    <dbReference type="GeneID" id="4392272"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05073"/>
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    <dbReference type="OMA" id="YAMIHCL"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
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        </location>
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        <location>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="103"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
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            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ88454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="685" mass="74174" checksum="B47EA33AAD19B98D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZX9</accession>
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        <recommendedName>
            <fullName evidence="4">Pre-rRNA-processing protein PNO1</fullName>
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        <name evidence="2" type="ORF">CHGG_04917</name>
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            <taxon>Sordariomycetes</taxon>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="interactions" value="808"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GZX9"/>
    <dbReference type="GeneID" id="4391546"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04917"/>
    <dbReference type="eggNOG" id="KOG3273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064992_0_2_1"/>
    <dbReference type="InParanoid" id="Q2GZX9"/>
    <dbReference type="OMA" id="KDWVHIF"/>
    <dbReference type="OrthoDB" id="1932641at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042255">
        <property type="term" value="P:ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23192" checksum="BF7B3BA0239B70F8" modified="2006-03-21" version="1">MPAPTALLQPAAVPEAALVPVPEQEDELLVDMQDANTVDPTAIAPPTTAEETDMVVDEEGRPRFAPGKDIDPVRRAETRKIPIPPNRMSALKSNWSKLQVRMNIKEKRVELRSSKFTTSNDSLQMGADFVSAFAMGFDIDDAIALLRLDSLYIQSFDIKDVRQTLGQDALGRAIGRIAGKDGVCRFFKFHAFALAKAEGCVVVYGGFIAAGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0F9</accession>
    <name>Q2H0F9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_04737</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223951.1">
        <property type="nucleotide sequence ID" value="XM_001223950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0F9"/>
    <dbReference type="FunCoup" id="Q2H0F9">
        <property type="interactions" value="600"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H0F9"/>
    <dbReference type="GeneID" id="4392521"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04737"/>
    <dbReference type="eggNOG" id="KOG0953">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010647_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H0F9"/>
    <dbReference type="OMA" id="QPANWYT"/>
    <dbReference type="OrthoDB" id="6692397at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045025">
        <property type="term" value="C:mitochondrial degradosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17913">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18805">
        <property type="entry name" value="SF2_C_suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000269">
        <property type="entry name" value="ATP-dependent RNA helicase SUPV3L1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000957">
        <property type="entry name" value="ATP-dependent RNA helicase SUV3L, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055206">
        <property type="entry name" value="DEXQc_SUV3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022192">
        <property type="entry name" value="SUV3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041082">
        <property type="entry name" value="Suv3_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044774">
        <property type="entry name" value="Suv3_DEXQc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22527">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12513">
        <property type="entry name" value="SUV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18147">
        <property type="entry name" value="Suv3_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="302"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="717"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="719"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ88118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="742" mass="83574" checksum="1525EA051BC9DBCF" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0I4</accession>
    <name>Q2H0I4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ferrochelatase</fullName>
            <ecNumber evidence="12">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_04712</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ferrochelatase family.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="12"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223926.1">
        <property type="nucleotide sequence ID" value="XM_001223925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0I4"/>
    <dbReference type="FunCoup" id="Q2H0I4">
        <property type="interactions" value="620"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H0I4"/>
    <dbReference type="GeneID" id="4392951"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04712"/>
    <dbReference type="eggNOG" id="KOG1321">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018884_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H0I4"/>
    <dbReference type="OMA" id="DPYHCEC"/>
    <dbReference type="OrthoDB" id="1323at2759"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1400:FF:000003">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ88093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="409" mass="45077" checksum="BF7F53DCE6F690D7" modified="2006-03-21" version="1">MALRLPAAMRPLRTFGLTKPSAHQVRWLATPAHPVTRDSGRGTAMVFLNMGGPSTTDEVGDFLSRLFSDGDLIPLGRLQGYIGPLLSKRRTPKIQKQYAAIGGGSPIRKWSEHQCAEMCKILDKICPETAPHKPYVAFRYANPLTEDMYRQMLADGFGNGRGGRAVAFTQYPQYSCSTTGSSLNELWKWRQRLEGKAGPLDDGSDGTIKWSVIDRWPAHSGLVEAFAQNIEAKLLEYPAEKRDKVVLLFSAHSLPMTVVNRGDPYPAEVAATVHAVMNRLKNVNPYRLCWQSQVGPQPWLGPQTSSSVEDYIAKGQKDLLLIPIAFTSDHIETLYELDEEVIGESGHADTVKRVESLNGSPVFIQALADLAKSHLTSGIACSTQMGLRCPGCKSERCAESKKFFASQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H119</accession>
    <name>Q2H119_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_04527</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="5"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223741.1">
        <property type="nucleotide sequence ID" value="XM_001223740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H119"/>
    <dbReference type="STRING" id="306901.Q2H119"/>
    <dbReference type="GeneID" id="4392621"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04527"/>
    <dbReference type="eggNOG" id="KOG1390">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H119"/>
    <dbReference type="OMA" id="SMGTFGE"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF156">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="14">
        <location>
            <begin position="37"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="15">
        <location>
            <begin position="305"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAQ87908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="428" mass="44833" checksum="DAC6CDD089B0224D" modified="2006-03-21" version="1">MAGQFRHALRVSSHLRTGSARLFSSQACLRQEIRDAYILSASRTPTAKFNGSFLSVTGPQLGAVAIKSALEKSKVPVSKITDVYMGNVLQGSVGQAPARQASVFAGLPPSVEAVTINKVCASGLKAVAFAAQNIQLGLSEAQIAGGFENMSRVPYYMPRASGLPGFGHVKMEDGLIKDGLTDVYDQIHMGNCAENTAKKYEISRETQDQYAIQSYQRAQAAWKNNAFADEIAPVTVKGRKGDTLITTDEGYLDVKLEKVPSLKPAFVRDGTGTVTAANSSTLNDGASALVLGSRAVAQEYGAGSRVLARICGSADAAVDPIDFPIAPAKAVPIALERAGITKDQVAVWEFNEAFAAVIKANEKILGLEGARVNPLGGAISLGHALGSSGSRILVTLLHQLKPGEYGVAAICNGGGAASAMVVQRIESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1C2</accession>
    <name>Q2H1C2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223638.1">
        <property type="nucleotide sequence ID" value="XM_001223637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1C2"/>
    <dbReference type="GeneID" id="4392516"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04424"/>
    <dbReference type="HOGENOM" id="CLU_1643482_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H1C2"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="161" mass="17487" checksum="66768DC409613094" modified="2006-03-21" version="1">MTLGCDRELLNHGPWLMPFPGQRGLPIPTTDIRDRNHDLCHRDSHERPPFSFGAEEREDDSYQVVGRKRLRGRPTNVAAAQRQALLDPQQTRINFEAPGVRFASPVVSGVDTTALPPRAPEPATGPTPTAAANPAVTATPDQRDAEGDTTMDSITVAGDEN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-09-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1P3</accession>
    <name>SEC11_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="1">3.4.21.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Signal peptidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SEC11</name>
        <name type="ORF">CHGG_04303</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1 2">Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3 (By similarity). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity). SPC associates with the translocon complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The C-terminal short (CTS) helix is essential for catalytic activity. It may be accommodated as a transmembrane helix in the thinned membrane environment of the complex, similarly to the signal peptide in the complex substrates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S26B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="1"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223517.1">
        <property type="nucleotide sequence ID" value="XM_001223516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1P3"/>
    <dbReference type="SMR" id="Q2H1P3"/>
    <dbReference type="FunCoup" id="Q2H1P3">
        <property type="interactions" value="597"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H1P3"/>
    <dbReference type="MEROPS" id="S26.010"/>
    <dbReference type="GeneID" id="4392489"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04303"/>
    <dbReference type="eggNOG" id="KOG3342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089996_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H1P3"/>
    <dbReference type="OMA" id="ILMNEYP"/>
    <dbReference type="OrthoDB" id="10257561at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0735">Signal-anchor</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000412323" description="Signal peptidase complex catalytic subunit SEC11">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Signal-anchor for type II membrane protein" evidence="3">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="4">
        <location>
            <begin position="36"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal short (CTS) helix" evidence="2">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P15367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P67812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="172" mass="19006" checksum="D4C3433C041D79AF" modified="2006-03-21" version="1">MLSSLQNPRQAAAQLMNFGLILSTAFMMWKGLSVITDSPSPIVVVLSGSMEPAFQRGDLLLLWNRNLISETNVGEIVVYNVKGKDIPIVHRIVRKFGVGPDAKLLTKGDNNAADDTELYARGQDYLNRKDIVGSVVGYMPFVGYVTIMLSEHPWLKTVMLGIMGLVVVLQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H242</accession>
    <name>Q2H242_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_04154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223368.1">
        <property type="nucleotide sequence ID" value="XM_001223367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H242"/>
    <dbReference type="STRING" id="306901.Q2H242"/>
    <dbReference type="GeneID" id="4393055"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04154"/>
    <dbReference type="eggNOG" id="ENOG502SJ7Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024672_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H242"/>
    <dbReference type="OrthoDB" id="3945550at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ87535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="636" mass="71533" checksum="DFD79A5858C65BDF" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2G9</accession>
    <name>Q2H2G9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223241.1">
        <property type="nucleotide sequence ID" value="XM_001223240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2G9"/>
    <dbReference type="GeneID" id="4392401"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04027"/>
    <dbReference type="HOGENOM" id="CLU_949956_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2G9"/>
    <dbReference type="OrthoDB" id="10580640at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="293" mass="32463" checksum="9ECF06BA59698451" modified="2006-03-21" version="1">MAEEQPPEYPSIADLLSAMDADAVAKANITTKTNVNPDLGFNTHPDPSFIPSPNPGPGFNPNPNPRPSLNRSPFIPNPNFNLRPPRIPQRRRHRPSPPKEILDDFGDIVLRVGGHAAPAATQEQRDFKVCSHTLRRVGSGGDRVLEQHAYRAAWRRGEAEAEADGEGQEGGDGDGDGDDGGEEEERDEEGCRVGIKYGMLKALQEWFGVGQELGVVWKEVKPGQLPLMDVLRLMDVAWELGWERELTELGMAFVMYWPLHGDNGIETVEEIRKNLFEQGVPLGPDGFFSESFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2N6</accession>
    <name>Q2H2N6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223174.1">
        <property type="nucleotide sequence ID" value="XM_001223173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2N6"/>
    <dbReference type="GeneID" id="4392497"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03960"/>
    <dbReference type="eggNOG" id="ENOG502RNM1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_831821_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2N6"/>
    <dbReference type="OMA" id="ILYIPRY"/>
    <dbReference type="OrthoDB" id="3513892at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="7"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="322" mass="34363" checksum="2D08B185A07000FF" modified="2006-03-21" version="1">MTSPTSFTLFPLLPPELRLQIYHHACHPRVTTLSYLPAPRDTYHCSTPPPPLLHISRESRAEGLRLYAKCLLPSPPSPPSPPTQQPPPDLTESPPEDDDPQPRRYFYHHPHLDTLYLPRPPRAADPLGLGYADWAREFAAGAATARTAVVTTTTTTTTAAATRTGPGAGPSGLAGVVRRLAVDYVPAEVRRPWEVFGKVCLIRGCPLLEEAYLVVQVSDGGEGRRQQRLGAAGLPPGGRRAVEFVDPAAGDAEIVRIMERVRASFRVELGDGAGEAGSVGSAAWGGLGKEGAEEGTGRGGLELVPKAMVLSPWGCRHVACAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3B0</accession>
    <name>Q2H3B0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_03736</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222950.1">
        <property type="nucleotide sequence ID" value="XM_001222949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3B0"/>
    <dbReference type="STRING" id="306901.Q2H3B0"/>
    <dbReference type="GeneID" id="4392189"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03736"/>
    <dbReference type="eggNOG" id="ENOG502QT9R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009570_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H3B0"/>
    <dbReference type="OMA" id="HMERPAN"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF1">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="530"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="3">
        <location>
            <begin position="110"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="471"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ87117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="71237" checksum="E24D1B8488E11CDA" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3G6</accession>
    <name>Q2H3G6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_06799</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222894.1">
        <property type="nucleotide sequence ID" value="XM_001222893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3G6"/>
    <dbReference type="GeneID" id="4391376"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06799"/>
    <dbReference type="eggNOG" id="ENOG502SX83">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_546271_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3G6"/>
    <dbReference type="OMA" id="SSANVEC"/>
    <dbReference type="OrthoDB" id="4573956at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ90180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="499" mass="54686" checksum="E26FA6ECA852B9B5" modified="2006-03-21" version="1">MTITDQPNSANWQDPSPGAFDFERLLDFGVKDIESRRNKPSRPLACQRCHGQKLRCVRRTSDAPICDRCSSANVECVSRQPQRMGRPAETTTNGLNSAHDAGRPGWRLKAHAESHSRPAGTPLLTATGGTKRRRKSPGDPSASSSPTDMVITYDSAARQFELDGWMWPSGPSLSDAAPPALTAASNTAHSSSGVSSSALVQPSTGFTSYVSPLGSFGSPNALLQSLDDLSNLFPANIEPPCFEPQRTPETSDGVSDDQLSPSDAVEHLSRLHLELYHCLVAVKAVEKMKRDRLRYQPPTKPGGDIDTSWSENLFRTTERFIEALEDYVGPQASDPCFRPSSGPAPTTMDDDQNRWEDTDPSNPGPQVDTATGLMIVSCYTRLVQIFDVVVFVVETFQDMDCPGSYVQVRFGDFTPTVNKRFQARALGQYVLHLLEGISDGVDRAVASRQPYARAVAEVRRNEGRLKERILTTFHGGRKPYLGASRGPTYPFVPKKGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3K5</accession>
    <name>Q2H3K5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_06760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222855.1">
        <property type="nucleotide sequence ID" value="XM_001222854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3K5"/>
    <dbReference type="STRING" id="306901.Q2H3K5"/>
    <dbReference type="GeneID" id="4390094"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06760"/>
    <dbReference type="eggNOG" id="ENOG502S5NF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030288_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3K5"/>
    <dbReference type="OMA" id="NDETHCQ"/>
    <dbReference type="OrthoDB" id="2142759at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="2">
        <location>
            <begin position="194"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ90141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="421" mass="47816" checksum="52C2A0786D29C9C0" modified="2006-03-21" version="1">MASVDLPGSLQTRTISGTMEDPTAASKFRLRPPLPPPIPPSDSTIATQPRTIAFRHPGYPDFGPNLLSLIAVDGGQGIEAGIDYDTALVACGIVACNNWSQSWFGIKDRSGGDTVFRAVPRPEDGILRESTYYFFVNQNQDEQYPVFPSFDHWRFPHRNLPELWQALDIPPFVPSSQSPNRDGKLAVAVRDQSCCLTAWTNATEASHLIPFASSTWFLVNNMSQYCRLPMRRDPVDDDRNLILLRRDLHLLFDQRHFTILPKRNPGDPLGTPSLVFHTWQPRGDRELHHLFHNRTLQQPTTGLSVEFLLARFAWSIFREQTYPFLTGIFEYTVQLFNPATRRVRIEIRNSLGLFSLLRILPSRTFNRPVSPAEQKVAPVDADSDAGEEDDFESDEEEDDPPRGRSRERKPMCMARPNIIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H432</accession>
    <name>Q2H432_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) endonuclease 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_06583</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
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        <property type="protein sequence ID" value="EAQ89964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_001222677.1"/>
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    <dbReference type="eggNOG" id="KOG1294">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_010374_2_0_1"/>
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    <dbReference type="OrthoDB" id="391817at2759"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZF_GRF"/>
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    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
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            <end position="642"/>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="14">
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            <end position="448"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="14">
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            <end position="493"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="14">
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            <end position="509"/>
        </location>
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            <end position="530"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="14">
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            <begin position="540"/>
            <end position="564"/>
        </location>
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        <location>
            <position position="9"/>
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        <ligand>
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        </source>
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        </source>
    </evidence>
    <sequence length="646" mass="71465" checksum="CCF48DA84F448D9D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4B3</accession>
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        </submittedName>
    </protein>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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            <end position="229"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ89883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="229" mass="25568" checksum="E4A330590CB1442B" modified="2006-03-21" version="1">MFRGTLRRFKPLPANKSPPIFQNYPIISTQTTPGADLSPQALQAFEPSERVAKFAAEHKISFPFALRLMPGQKVKDFPLRVSIAPRNVFSMYHLKYLGPFEHPLISKVLYTYEQEKKTKPLWCYVQGFSTADNSNAVVRQTSERVVRAALFRALNAAGYDSFGKSLDGSKKDLRGSIRVAVAEPKAIMKIEFDKLLGYLTKLVANAIPRLDGSSPGPPQRPRKPSTSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4C6</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
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                <person name="Untereiner W.A."/>
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                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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            <end position="57"/>
        </location>
    </feature>
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        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="341" mass="39391" checksum="FBA8B9BAA73E6E7A" modified="2006-03-21" version="1">MKLTPIKVKGKAGQLKKWKPPPPEPARRSKRRRDDDDEGSDSKDGSRRRRFKSKRPAAPVEELPTEVLERIILMSRNLNVLRSSLRIGYRFSSPVFLTELLEAAFAPTWGAWFGYDRNVSAVLACRWVNTTLVLEAQQKWYRRNCGPGNLLEHLNPLGRSRAEYALALWSSNGGRDDTTARFEKDWERFKVSCANLFAADRPRLADIDTIWEQAMYMDLHPLTKVPERFLTTPFNWETAKATYWLVRGGGQLLAAQMSSWELTKKGYDRVMKLADQQLILVLLVLWVKLRVFDHWPGFLLEQELDVSQQMQQSESPADRKLWLWAFELMGCRGALGEPQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4Y2</accession>
    <name>Q2H4Y2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_06283</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222378.1">
        <property type="nucleotide sequence ID" value="XM_001222377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4Y2"/>
    <dbReference type="GeneID" id="4391306"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06283"/>
    <dbReference type="eggNOG" id="ENOG502RS92">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1396149_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4Y2"/>
    <dbReference type="OrthoDB" id="5424149at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="195" mass="22433" checksum="D90384931E9D8B06" modified="2006-03-21" version="1">MGNPKKSTHRDSDDMTSTKSLAITAPGFNGILDFLDPKPPKKLEDIRERLQSHGQLRHLLSQFYARNQALAYQRKFDPLNHASVITSTTDGTTLNQYAHYAEELEDGTTKYHQYRIKSTNPNSHEDFKDGYKRLRNAQDYAKGQSYILKDELQGHWKQQRSSGRNVITEGPRGTDLACTRHRTSIYKRMMTITKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H567</accession>
    <name>Q2H567_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_06198</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222293.1">
        <property type="nucleotide sequence ID" value="XM_001222292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H567"/>
    <dbReference type="STRING" id="306901.Q2H567"/>
    <dbReference type="GeneID" id="4390700"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06198"/>
    <dbReference type="eggNOG" id="KOG3138">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054412_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H567"/>
    <dbReference type="OMA" id="HGIAMHL"/>
    <dbReference type="OrthoDB" id="47374at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="84"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="322"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ89579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="453" mass="47151" checksum="8B29BADE0DD63541" modified="2006-03-21" version="1">MSRIQQSSIRSFFQPRRQPEYAAPPSTAPLENGNVATQSTSKPPVSPSADHLNATSTEPVKIPITLPPSGIPILPSPPSLPSGATIVPLVQEHVPALRRINSLLLPVPYPDSFYAKVLDPLASGLFSRAILWQDSDADTPKVIGGLICRLEPNPFLDTQGQLIPHPFPPSHLQKPSNVPLNTPYHAIYIQSLALLSPYRSLGLAAAALEHIIASATILPAAGSSIDARTIYAHVWTENEEGLKWYEARGFAREGAEPMKEYYFKLRPGTAWVVRRHIGPTAAAAAANLTTTATTTTTTAPALPPTTSTSSSESVLAAAVNLPLLAPKPPPPPPPPPRAPTPGTSGGGGPPRRPSAPPSANASSTSLSFQNARPESEWNDLPADMVSTGKVGSGSNNTNSPRLLSPDAAAAAANGSGGRAGAGAGTPVSGASSRSSSTGRKKRDRTYPTAAFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-09-13" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5V2</accession>
    <name>Q2H5V2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222058.1">
        <property type="nucleotide sequence ID" value="XM_001222057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5V2"/>
    <dbReference type="GeneID" id="4390808"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05963"/>
    <dbReference type="HOGENOM" id="CLU_2468857_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5V2"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208544" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9668" checksum="AAB6F91097132263" modified="2006-03-21" version="1">MICLLCSWLLPILAQLNARHGAARTTTPVLAYPTRRNKAKSRMQNLLLLSRSPSAASVTQWVVPGLHGICRKTPDTTAPAEFDREIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5X5</accession>
    <name>Q2H5X5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222035.1">
        <property type="nucleotide sequence ID" value="XM_001222034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5X5"/>
    <dbReference type="STRING" id="306901.Q2H5X5"/>
    <dbReference type="GeneID" id="4390717"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05940"/>
    <dbReference type="HOGENOM" id="CLU_1447512_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5X5"/>
    <dbReference type="OrthoDB" id="3199516at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="187" mass="19923" checksum="3BD2CC469A231AAF" modified="2006-03-21" version="1">MGQVSPQTFSNSLGSPGRHPTADYQGYSPEIMVIEYMAYSTGGMILGSLVANAIGRMGNLEIFSWDMPTGVHPRVFEALGSLAHRPGRTFTRAPGHRFRTPNPLDGPSLEQIDHRARWLGESTVGARRLGGVLGLLVGKVYDIPKRKIQAQPALDAPGFQPGETTPFLPTLSKGLKSGSPNSAGGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6I5</accession>
    <name>Q2H6I5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">50S ribosomal protein L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_05730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221825.1">
        <property type="nucleotide sequence ID" value="XM_001221824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6I5"/>
    <dbReference type="FunCoup" id="Q2H6I5">
        <property type="interactions" value="664"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H6I5"/>
    <dbReference type="GeneID" id="4390101"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05730"/>
    <dbReference type="eggNOG" id="KOG1715">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086499_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H6I5"/>
    <dbReference type="OMA" id="LEDKWGV"/>
    <dbReference type="OrthoDB" id="250175at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L7/L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_bL12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_bL12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="Ribosomal protein L7/12, oligomerisation (N-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL12 oligomerization" evidence="5">
        <location>
            <begin position="18"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein bL12 C-terminal" evidence="4">
        <location>
            <begin position="82"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ89111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="15712" checksum="4B3B1B9F6ABAD825" modified="2006-03-21" version="1">MSRRYNSTEAAPAATNPKISAIVDQISQLTLLETADLVSSLKTRLNIPDLPVGGFAAAPAGPAAAPVEEEEAAPAAAEKTLFTVKLQSFEAGSKPKVIKEIKNLLGLSLVDSKKFVESAPKLMKESVPKDEAEKILATMKELGAVVVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6K7</accession>
    <name>Q2H6K7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_05708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221803.1">
        <property type="nucleotide sequence ID" value="XM_001221802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6K7"/>
    <dbReference type="GeneID" id="4390523"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05708"/>
    <dbReference type="HOGENOM" id="CLU_1767834_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6K7"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="147" mass="15843" checksum="B7C5B2B5D48FE0ED" modified="2006-03-21" version="1">MGREPWPSGTVHLCGYLAARSLFCSLQGHGAQSSVAMRPLSGYMTLHKPIERHANQQPPWFFIIGEAIFKRVETPMEVSPVSPQGVSLSRGTAAPAQMVGPQSGNPADSLPIAGFCDKNTPRISCIFPMRQTAGLGAQGGRFRKHID</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6M3</accession>
    <name>Q2H6M3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221787.1">
        <property type="nucleotide sequence ID" value="XM_001221786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6M3"/>
    <dbReference type="GeneID" id="4391105"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05692"/>
    <dbReference type="eggNOG" id="KOG2458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005027_3_1_1"/>
    <dbReference type="InParanoid" id="Q2H6M3"/>
    <dbReference type="OMA" id="HEWTEEF"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF104">
        <property type="entry name" value="PROTEIN CAP1, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05595)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="476"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="617" mass="69783" checksum="6B2619B938619887" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H708</accession>
    <name>Q2H708_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphingolipid C(9)-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.317</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CHGG_05557</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.317" evidence="14"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221652.1">
        <property type="nucleotide sequence ID" value="XM_001221651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H708"/>
    <dbReference type="STRING" id="306901.Q2H708"/>
    <dbReference type="GeneID" id="4390067"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05557"/>
    <dbReference type="eggNOG" id="ENOG502QS47">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026434_5_0_1"/>
    <dbReference type="InParanoid" id="Q2H708"/>
    <dbReference type="OMA" id="GFKTWLF"/>
    <dbReference type="OrthoDB" id="412182at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052290">
        <property type="entry name" value="Sphingo_C9-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197:SF1">
        <property type="entry name" value="SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197">
        <property type="entry name" value="SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAQ88938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="524" mass="59037" checksum="FCBA29EBB84515C5" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7I1</accession>
    <name>Q2H7I1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pre-mRNA-processing factor 19</fullName>
            <ecNumber evidence="16">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_05384</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 21">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the WD repeat PRP19 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="16"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221479.1">
        <property type="nucleotide sequence ID" value="XM_001221478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7I1"/>
    <dbReference type="FunCoup" id="Q2H7I1">
        <property type="interactions" value="364"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H7I1"/>
    <dbReference type="GeneID" id="4389999"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05384"/>
    <dbReference type="eggNOG" id="KOG0289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3033">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_348186_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7I1"/>
    <dbReference type="OMA" id="WRESHTS"/>
    <dbReference type="OrthoDB" id="687049at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16656">
        <property type="entry name" value="RING-Ubox_PRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000027">
        <property type="entry name" value="Pre-mRNA-processing factor 19, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038959">
        <property type="entry name" value="Prp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013915">
        <property type="entry name" value="Prp19_cc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055340">
        <property type="entry name" value="RING-Ubox_PRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08606">
        <property type="entry name" value="Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 16" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12 16" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="14 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7 16" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4 15" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="U-box" evidence="17">
        <location>
            <begin position="329"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="604"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ88765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="807" mass="86599" checksum="8E43A4F99D03EAA7" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7Y6</accession>
    <name>Q2H7Y6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_03668</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230184.1">
        <property type="nucleotide sequence ID" value="XM_001230183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7Y6"/>
    <dbReference type="FunCoup" id="Q2H7Y6">
        <property type="interactions" value="933"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H7Y6"/>
    <dbReference type="GeneID" id="4388388"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03668"/>
    <dbReference type="eggNOG" id="KOG1195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006406_6_2_1"/>
    <dbReference type="InParanoid" id="Q2H7Y6"/>
    <dbReference type="OMA" id="YEFKWER"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07956">
        <property type="entry name" value="Anticodon_Ia_Arg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000058">
        <property type="entry name" value="Mitochondrial arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
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        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
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    </dbReference>
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        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
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    </dbReference>
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    </dbReference>
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            <end position="114"/>
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        <location>
            <begin position="517"/>
            <end position="633"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="26"/>
        </location>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ91733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="633" mass="71454" checksum="C387F4D2DB3B26A1" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8J1</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">CHGG_03463</name>
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000001056">
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ91528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="165" mass="17417" checksum="3DDE0D14C7757D8F" modified="2006-03-21" version="1">MHATSITQHAESVIQTAACSFLRLDPATQKENHTALLASQNFVLARCAAYNLCGNNSGDSAPPDPKTRSGGEARSCTTCHNPFDQLRGFKEVVHNWRAMTTGGGTVKSLEVGIFELVNENDGYLPKTSHGPGEEGGNRTAPCDFAALVVDREDGLGLVSESGALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8R9</accession>
    <name>Q2H8R9_CHAGB</name>
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        <recommendedName>
            <fullName evidence="4">Erythromycin esterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8R9"/>
    <dbReference type="STRING" id="306901.Q2H8R9"/>
    <dbReference type="GeneID" id="4388778"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03385"/>
    <dbReference type="eggNOG" id="ENOG502T00Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015328_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8R9"/>
    <dbReference type="OMA" id="GHASAWR"/>
    <dbReference type="OrthoDB" id="5204833at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="719" mass="77033" checksum="73B68B87188A90B3" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8V5</accession>
    <name>Q2H8V5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_03349</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229865.1">
        <property type="nucleotide sequence ID" value="XM_001229864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8V5"/>
    <dbReference type="STRING" id="306901.Q2H8V5"/>
    <dbReference type="GeneID" id="4388953"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03349"/>
    <dbReference type="eggNOG" id="KOG1591">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011017_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H8V5"/>
    <dbReference type="OMA" id="CATAINQ"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF10">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="236"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="608"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="694"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="762"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="696"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="776"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="798"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ91414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="828" mass="88875" checksum="548BFFFF942653FF" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9P0</accession>
    <name>Q2H9P0_CHAGB</name>
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        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_03064</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001229579.1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="4389065"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015768_7_1_1"/>
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    <dbReference type="OMA" id="DIIYNRF"/>
    <dbReference type="OrthoDB" id="428822at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:glutamate-tRNA ligase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
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    </dbReference>
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        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
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        <property type="entry name" value="GluQ/Sye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311:SF2">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="An anticodon-binding domain of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="502"/>
        </location>
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        <location>
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        </location>
    </feature>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ91129.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="522" mass="58136" checksum="AE0C3C92139E0AFC" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HA67</accession>
    <name>Q2HA67_CHAGB</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">CHGG_02887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229403.1">
        <property type="nucleotide sequence ID" value="XM_001229402.1"/>
    </dbReference>
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        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HA67"/>
    <dbReference type="GeneID" id="4389510"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02887"/>
    <dbReference type="eggNOG" id="ENOG502QQBW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033072_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HA67"/>
    <dbReference type="OMA" id="CSEEHWA"/>
    <dbReference type="OrthoDB" id="5282002at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046824">
        <property type="entry name" value="Mss51-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032717">
        <property type="entry name" value="Mss51_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069">
        <property type="entry name" value="GH20023P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069:SF1">
        <property type="entry name" value="PROTEIN MSS51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20179">
        <property type="entry name" value="MSS51_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13824">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial splicing suppressor 51 zinc-finger" evidence="2">
        <location>
            <begin position="129"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial splicing suppressor 51-like C-terminal" evidence="3">
        <location>
            <begin position="366"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="354"/>
        </location>
    </feature>
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        <location>
            <begin position="322"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ90952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="503" mass="56218" checksum="BA3D146F98929B6B" modified="2006-03-21" version="1">MALPAEIAARSALSRICTRCSVSLKRRGQAPNGFLHASWQQRRSQSRKSSSRTITQIDKLATPAARPAQNQNPVVRRFSSGFAQTSTTPPSESQPKQILAEDDLFHSFTNSPNPAIRQRAAFIRQHASCPHHDHQPGGSIAPAHVDFECPDCGIPVYCSKEHWADDYEAHLLICDTLRQINEDDHDLRSGRSFPEFDYAEPQMEDALVNMSSWDTFLYTRQFNAINDDRSMRQATRLLTYPITIGSILHELSPYNIKPGGRITPEGIKSFSALRYTLHPAKTGGGSDIKGLRMQAPAVRLFILGARAESSLSPGCLGSAGPSLPSSRESTSSSSARRAMLNRDDELSAVPPRTPTNPFGAIVEDRVWPTMKISTIVDYYHTIHKTGHFYPYDPYFDCFVMFHPGLGHPASSHEWEETLPMLLETKAPIIVTGYTQADMERDIDFVHKTAAGEFDVLMEPGQNKFSSLRWDLNDLDPQDISAGNWGVWAFRGKRYETTHKSTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAM8</accession>
    <name>Q2HAM8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_02726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229242.1">
        <property type="nucleotide sequence ID" value="XM_001229241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAM8"/>
    <dbReference type="SMR" id="Q2HAM8"/>
    <dbReference type="STRING" id="306901.Q2HAM8"/>
    <dbReference type="GeneID" id="4389417"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02726"/>
    <dbReference type="eggNOG" id="KOG1902">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011694_4_2_1"/>
    <dbReference type="InParanoid" id="Q2HAM8"/>
    <dbReference type="OMA" id="GFQSIGR"/>
    <dbReference type="OrthoDB" id="306690at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057720">
        <property type="entry name" value="RRM_YTH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25701">
        <property type="entry name" value="RRM_YTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="2">
        <location>
            <begin position="185"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ90791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="429" mass="46210" checksum="0B82F91D776E8D48" modified="2006-03-21" version="1">MYRGNPAPGRYRPSATPQYQDPRNRQPQHSGQEVNAAPPSPQDNGVTGGRQSIVRGPPRKPRQSVSPQGHAIWVGNLPPQTDLMSLVHHVCKETEGLESLFLISKSNLSRLRKSTVEGPAGATAPTGPAASTSQGGAMAIQEASLSENGDGETKEKGVIPDAVAAAAPESQATIPAVNGRPRQKDRFFVLKSLTVEDLELSVRTNIWATQSHNEEMLNSAYKTSDNVYLVFSANKSGEYFGYARMASAINEDPAAAIEFAPSAQPANEVDLPKAIPTDPTEFAPRGRIIDDSARGTIFWEANWEDKTASDGGQDDEGSSGSAGGDTGSVQSGQESNMSEPKAWGKPFRLEWLSTTRLPFFHTRGLRNSFNSNREVKIARDGTEIEPTVARTLIGKFYRAQGPMLGMLPPVVPGGFRMQAPVTVGYPPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAW1</accession>
    <name>Q2HAW1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_02643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229159.1">
        <property type="nucleotide sequence ID" value="XM_001229158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAW1"/>
    <dbReference type="GeneID" id="4389486"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02643"/>
    <dbReference type="eggNOG" id="ENOG502RZ22">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014887_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HAW1"/>
    <dbReference type="OMA" id="TWTGMEE"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054464">
        <property type="entry name" value="ULD_fung"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22893">
        <property type="entry name" value="ULD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="478"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ90708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="695" mass="77355" checksum="8C4DE90D9E9C38B9" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBK0</accession>
    <name>Q2HBK0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acyl-CoA dehydrogenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_02404</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228920.1">
        <property type="nucleotide sequence ID" value="XM_001228919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBK0"/>
    <dbReference type="GeneID" id="4389680"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02404"/>
    <dbReference type="eggNOG" id="ENOG502S9JP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_10_1_1"/>
    <dbReference type="InParanoid" id="Q2HBK0"/>
    <dbReference type="OMA" id="HNWDNVG"/>
    <dbReference type="OrthoDB" id="5356974at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000020">
        <property type="entry name" value="Putative acyl-CoA dehydrogenase YdbM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000025">
        <property type="entry name" value="Related to Dibenzothiophene desulfurization enzyme C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000032">
        <property type="entry name" value="Thermophilic desulfurizing enzyme family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="3">
        <location>
            <begin position="39"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase C-terminal" evidence="4">
        <location>
            <begin position="269"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ90469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="47591" checksum="488C55CE910B8B89" modified="2006-03-21" version="1">MATSALPVISKAPSSSDPAVYQEYESKWSTYPTDTEGWLQRARDVAAVLVVDAAAREKANKSPRAEVALLKHSGLLKLLGPKKYGGGEQPWSVGYKAIREVAKGDGSIGMLLGYHLLWSRTANVVGSDEQADRLQKFIIENNYYVGGAVNPRDSDLKITYDDEKITYSGFKNFTTGAAVSDLIVLEGAVDGRPPEEHIFAIVPTAQAGIVFSYNWDNIGLRLTESGAAKVENVSAPWADALGWDAKTKKPDPAVLGIPFPSLLLPSIQLVFSNFYLGIALGALDFAKQYTVAHTRAWPYGGDTKESATEEFHILSTYGNFHAHLRAAEALADRAGAEADRLYGTYAANRAGLTPQERGDWAEWVASVKVVATDTGLRVTSGVFEVTGARATASKVGLDRFWRDLRTHTLHDPVAYKNRELGRYFLLGQSPEPTWYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCB2</accession>
    <name>Q2HCB2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_02142</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228658.1">
        <property type="nucleotide sequence ID" value="XM_001228657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCB2"/>
    <dbReference type="FunCoup" id="Q2HCB2">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HCB2"/>
    <dbReference type="GeneID" id="4389040"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02142"/>
    <dbReference type="eggNOG" id="KOG3996">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048602_1_2_1"/>
    <dbReference type="InParanoid" id="Q2HCB2"/>
    <dbReference type="OMA" id="SCPVDHK"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="70"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ90207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="320" mass="35039" checksum="7AB94CCA3AF59259" modified="2006-03-21" version="1">MYTDLLDTVLVNPKNATVQENNIGPKAAEPRGAATAMKGRGHEVSGVASEADEEAKCPVDHKTRELWLQQAQRERASQAATPSAPQNLQTTSTIPSRQPASSWSSWLRLPSFSRQPQSEAPSTAQQPPRPQSRLDESREISSIPRTSDPGPAACPANDEQETGASSTGHWVYPSEKQFFEAMKRKGHEAAAADMRTVVPIHNAVNERAWAEILKWEAPYVEPVAKGGCGGPKLHSFAGLGSATMSPKARINTLLGYTAPFDRHDWVIDRCGTQVEYVIDFYSGRNDGPGKGKLNFYLDVRPKLNTWEGVKMRAMRAVGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCE3</accession>
    <name>Q2HCE3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_02111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221332.1">
        <property type="nucleotide sequence ID" value="XM_001221331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCE3"/>
    <dbReference type="GeneID" id="4386300"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02111"/>
    <dbReference type="eggNOG" id="KOG1121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001248_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCE3"/>
    <dbReference type="OrthoDB" id="4570014at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ93876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="52348" checksum="47F723C29C0247F2" modified="2006-03-21" version="1">MVMLIVDEINQVGGLTLAAVDSRLRQYRDDQHRPFGGIPTVMFFGDFFQFDPVLQTSLLLPMPRDPGGQRPDSSAKHLAAHKLFLQFANVVILGEQVRAAGCPRLRGFLRRLRSGEQTELDFQRLSQRLYTPSCKYSFVDALRAITPLNQDRWDLNMAAVVQWARAHGKHISVFVAKHDTESGKRLSAGDLCHVLLYGDDSQLPTSGLFFYAQGMPVVVTRNQFVGLKVVNGAPFTAVDIFPDLAAGTIALASDVTLHLGPPVAVLLQSDDSAGLAIPGLPNGTILIKSKTVAIPSQMRGKEGRWRGKPGFRWVTHRTGPLCTPAFAMTDQKSQGKQFSDVLVNLKGVHSSGTATRPSFMSLYVQLSRAQSWDGLHLFRTPARGDFIEPKNVLDKDMRDAILKLKRRGEETRRRFEQDHRSEPWFQEWAAMPESGQGTETDEVEDAALWRDPGGEMERLFFMGRFMGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCH5</accession>
    <name>Q2HCH5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_02079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221300.1">
        <property type="nucleotide sequence ID" value="XM_001221299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCH5"/>
    <dbReference type="GeneID" id="4386648"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02079"/>
    <dbReference type="HOGENOM" id="CLU_1895953_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCH5"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ93844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="134" mass="14602" checksum="F9F894AD948293EA" modified="2006-03-21" version="1">MAASQRVHGKAVAIAVCDMEAQRQRTSGWVSLGRHCNENGIDQTEPVNAWHVNGQRKTPEVNRVVEGLKMYLEVFCCTLPTPCGFPMPKRIVSEGHNAYLSRTGSSAFGMIGGVARTTRHGARYMLNGAQRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCI6</accession>
    <name>Q2HCI6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_02068</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221289.1">
        <property type="nucleotide sequence ID" value="XM_001221288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCI6"/>
    <dbReference type="STRING" id="306901.Q2HCI6"/>
    <dbReference type="GeneID" id="4386670"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02068"/>
    <dbReference type="eggNOG" id="KOG0022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_14_1_1"/>
    <dbReference type="InParanoid" id="Q2HCI6"/>
    <dbReference type="OMA" id="CHTDLSC"/>
    <dbReference type="OrthoDB" id="1560166at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08278">
        <property type="entry name" value="benzyl_alcohol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350:SF11">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350">
        <property type="entry name" value="NAD-DEPENDENT ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="39"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ93833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="415" mass="43579" checksum="FEEA09F9E8BB1932" modified="2006-03-21" version="1">MEKFLQRRTVKPTSQALEVSHPILAIAMTRTTTALVVPELNGKFQLREVQLDDMQPDEVLVEIHASGLCHTDLSFATGVLPCEPNAVLGHEGAGVVLAAGSAVQHVSAGDKVLLSFSYCEACAACTSGHPAYCHGFNARNFGGRRPDGTPSLFASASVPAPGEQAGAGEGTAGKGLFSAFFGQSSFARHTLAHRSTVVRVPPETDLALYAPLGCGMQTGAGAILNSLGVRPGSSVAVFGVGSVGMAAVMAAAKIAGAGVVVAVDLQQSRLELAMKLGATHAVLGSEKDVVGRIREICPPLGVDYAVDCTGVPAVIRTMIDSLGTRGRGATVGAPGFGKCVSVDVMEHLTYGKEYVGCVEGDSLPEKFIPYLMDVHRKGQFPLEEFVRYYDFQDHEKAIEDTHSGEVIKAVLRWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCY4</accession>
    <name>Q2HCY4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA repair protein RAD50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_01920</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221141.1">
        <property type="nucleotide sequence ID" value="XM_001221140.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2HCY4">
        <property type="interactions" value="911"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HCY4"/>
    <dbReference type="GeneID" id="4386439"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01920"/>
    <dbReference type="eggNOG" id="KOG0962">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006184_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCY4"/>
    <dbReference type="OMA" id="FSDYYYR"/>
    <dbReference type="OrthoDB" id="18797at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000947">
        <property type="entry name" value="DNA repair protein RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001195">
        <property type="entry name" value="DNA repair protein rad50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13558">
        <property type="entry name" value="SbcC_Walker_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="17">
        <location>
            <begin position="6"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="328"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="783"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="187"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="470"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="587"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="813"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="947"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ93685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1282" mass="147375" checksum="115A6B635C40D069" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDP6</accession>
    <name>Q2HDP6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_01658</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220879.1">
        <property type="nucleotide sequence ID" value="XM_001220878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDP6"/>
    <dbReference type="FunCoup" id="Q2HDP6">
        <property type="interactions" value="1560"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HDP6"/>
    <dbReference type="GeneID" id="4387799"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01658"/>
    <dbReference type="eggNOG" id="KOG4124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013026_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HDP6"/>
    <dbReference type="OMA" id="STVQDMD"/>
    <dbReference type="OrthoDB" id="3269380at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000676">
        <property type="entry name" value="C2H2 transcription factor (Sfp1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="565"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="626"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="268"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ93423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="689" mass="75108" checksum="90DB8F7B8D6104C6" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDX8</accession>
    <name>Q2HDX8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proteasome component PUP3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_01576</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220797.1">
        <property type="nucleotide sequence ID" value="XM_001220796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDX8"/>
    <dbReference type="FunCoup" id="Q2HDX8">
        <property type="interactions" value="980"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HDX8"/>
    <dbReference type="MEROPS" id="T01.P02"/>
    <dbReference type="GeneID" id="4387247"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01576"/>
    <dbReference type="eggNOG" id="KOG0180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_10_0_1"/>
    <dbReference type="InParanoid" id="Q2HDX8"/>
    <dbReference type="OMA" id="CSEQLYG"/>
    <dbReference type="OrthoDB" id="204949at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000003">
        <property type="entry name" value="Proteasome subunit beta type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ93341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21236" checksum="6BAC6E7F94A045AD" modified="2006-03-21" version="1">MVGKDCVAIACDLRLGLQALTVSNNFPKVFQYGENVFLGLTGLATDVSTVSDLFRYKVNMYRLREERHIAPRTFANLVSSSLYERRFGPYFVSPVVAGLDPTTGAPFICGFDSIGCIDFAKDFIVSGTATEQLFGMCESLWEPDMGPDALFETISQSLLNAVDRDALSGWGAHVYIIEKDKVTKRLLKGRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HE30</accession>
    <name>Q2HE30_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_01524</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220745.1">
        <property type="nucleotide sequence ID" value="XM_001220744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HE30"/>
    <dbReference type="STRING" id="306901.Q2HE30"/>
    <dbReference type="GeneID" id="4388065"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01524"/>
    <dbReference type="eggNOG" id="ENOG502QSVZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013753_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HE30"/>
    <dbReference type="OMA" id="KSYWWIF"/>
    <dbReference type="OrthoDB" id="2115177at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF5">
        <property type="entry name" value="DUF907 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G06100)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208831" description="ML-like domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="585"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="22"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="674"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="694"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ93289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="818" mass="86139" checksum="B21889C36BA6E214" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HE61</accession>
    <name>Q2HE61_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="4 14">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_01493</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the sequential decarboxylation of four acetate groups of uroporphyrinogen-III (octacarboxyporphyrin) to yield coproporphyrinogen-III (tetracarboxyporphyrin) with the formation of intermediate hepta-, hexa- and penta-carboxylate porphyrinogens in the heme biosynthesis pathway. Acts on a number of porphyrinogens, but only coproporphyrinogen III can ultimately be converted to heme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>uroporphyrinogen I + 4 H(+) = coproporphyrinogen I + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:31239"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62626"/>
            <dbReference type="ChEBI" id="CHEBI:62631"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="4 14"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220714.1">
        <property type="nucleotide sequence ID" value="XM_001220713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HE61"/>
    <dbReference type="FunCoup" id="Q2HE61">
        <property type="interactions" value="806"/>
    </dbReference>
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        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
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        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ93258.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000001056"/>
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    </evidence>
    <sequence length="370" mass="41903" checksum="76D734C9DBB9E851" modified="2006-03-21" version="1">MEHQFPPLQNDLILRVARGEKVERPPIWVMRQAGRYLPEYHEAKGGRDFFECCRDPEVASTLTLQPIERYGGLLDASIIFSDILVIPQAMGMVVEMVDKKGPHFPSPLQSPDDGQYAEVMKRNVDVAKELDYVYKAITLTRKKLQGRVPLFGFCGAPWTLFCYMVEGGGSKFFKETKKWIYKYPEETKALLQKISELCVEYLALQVKAGAQLIQVFDSWAGELSPSSFKKFSQPYLEYIAKHLPPRLKEMGLEPVPMVVFPKGAWYALDAACNMGYHIVGLDWLHDPAEAVKTVGDRPVVLQGNADPGVLYGSHAGITEVVEEMVKGFDWANRRKGWIVNLGHGITPFVNPDDLKFFFQEIHRLTKTDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEB4</accession>
    <name>Q2HEB4_CHAGB</name>
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        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">CHGG_01440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
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        <dbReference type="NCBI Taxonomy" id="306901"/>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF2">
        <property type="entry name" value="RESISTANCE PROTEIN ARS2, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="670"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
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        <location>
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            <end position="158"/>
        </location>
    </feature>
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        <location>
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            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="506"/>
        </location>
    </feature>
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        <location>
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            <end position="609"/>
        </location>
    </feature>
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        <location>
            <begin position="741"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="805"/>
            <end position="911"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
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        <location>
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            <end position="77"/>
        </location>
    </feature>
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        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
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        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="911" mass="102488" checksum="D20CC4BCF5F7EF4D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEL8</accession>
    <name>Q2HEL8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_01336</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220557.1">
        <property type="nucleotide sequence ID" value="XM_001220556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEL8"/>
    <dbReference type="GeneID" id="4386432"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01336"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001248_0_2_1"/>
    <dbReference type="InParanoid" id="Q2HEL8"/>
    <dbReference type="OrthoDB" id="5095382at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:telomere maintenance"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
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        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF6">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="385"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="889"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ93101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="922" mass="101129" checksum="F57339B6A843A70D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEU8</accession>
    <name>Q2HEU8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220477.1">
        <property type="nucleotide sequence ID" value="XM_001220476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEU8"/>
    <dbReference type="STRING" id="306901.Q2HEU8"/>
    <dbReference type="GeneID" id="4386889"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01256"/>
    <dbReference type="eggNOG" id="ENOG502SBT7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_410482_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HEU8"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="669" mass="76259" checksum="F5FBA1ACD995E8C5" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEZ0</accession>
    <name>Q2HEZ0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_01214</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220435.1">
        <property type="nucleotide sequence ID" value="XM_001220434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEZ0"/>
    <dbReference type="SMR" id="Q2HEZ0"/>
    <dbReference type="FunCoup" id="Q2HEZ0">
        <property type="interactions" value="867"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HEZ0"/>
    <dbReference type="GeneID" id="4387400"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01214"/>
    <dbReference type="eggNOG" id="KOG1541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055194_0_2_1"/>
    <dbReference type="InParanoid" id="Q2HEZ0"/>
    <dbReference type="OMA" id="WIQEKKE"/>
    <dbReference type="OrthoDB" id="2877at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000017">
        <property type="entry name" value="probable 18S rRNA (Guanine-N(7))-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="9">
        <location>
            <begin position="52"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal" evidence="10">
        <location>
            <begin position="210"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ92979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="30295" checksum="EF0C3C47694FDDE6" modified="2006-03-21" version="1">MSRPEDTLAADIHYDDVEARKYTTSSRIQNIQASMTRRALELLDLKSPSLILDVGCGSGLSGEILSGVLEDEGGPHVWVGMDVSASMLDVALQRDVEGDLFLADIGQGVPFRAGTFDAAISISAIQWLCNAENSETSPAGRLSRFFNGLYASLKRGGMAVCQFYPKNDIQKQMITSAAVKAGFGAGLLEDDPDTKNVKVYLVLTVGSSAVANKGGDITGVVEGMDNVDVMDHRKKAKTGKGDIKKGSKAWIIKKKEQMERKGKIVKSTSKFTGRKRRIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEZ5</accession>
    <name>Q2HEZ5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_01209</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220430.1">
        <property type="nucleotide sequence ID" value="XM_001220429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEZ5"/>
    <dbReference type="SMR" id="Q2HEZ5"/>
    <dbReference type="FunCoup" id="Q2HEZ5">
        <property type="interactions" value="570"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HEZ5"/>
    <dbReference type="GeneID" id="4387027"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01209"/>
    <dbReference type="eggNOG" id="KOG0201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_2_1_1"/>
    <dbReference type="InParanoid" id="Q2HEZ5"/>
    <dbReference type="OMA" id="EVHYTSP"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000488">
        <property type="entry name" value="Related to severin kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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            <begin position="22"/>
            <end position="261"/>
        </location>
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        </location>
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        <source>
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        </source>
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        </source>
    </evidence>
    <sequence length="557" mass="62336" checksum="AEEDE06FB9612991" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFI1</accession>
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    </gene>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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            <end position="79"/>
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            <end position="60"/>
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            <begin position="61"/>
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    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ92788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="355" mass="38243" checksum="42000C3B6A854256" modified="2006-03-21" version="1">MSTLAADVTYDFTFPSCDPTTPPSFTFDPSLLEIPYNPGHARSSSHGSVYSFESSPSDSLTAPSTRRTTPARSPIRTHGPLLLPKIRSQDQAMIPSAVATPGRPSGQTNPETISYSAALTFAEDSNPAPLLCSPVSFTRESSVMDSRRASSCSLDNVTVDNYFQAYQMPTYMPARASSSPTPPPQPQALSQPEPFLYQQYMPRGPSPLAAAAPITPEVTPSTTLYSYLTAPNRAPSLVRNLSFPLRDPNTKHFWWDVRQVRPWTDFTASSILSMPGAAGCLSTPVSSALLPTPITSQRHPETEAALHSIYAAHYLPKLNNALALCSQRPLKLSVAPTKPAAASKANNLGMTTDCI</sequence>
</entry>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:myosin filament"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="F:microfilament motor activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF7603"/>
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        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
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    </dbReference>
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        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="901"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
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        <location>
            <begin position="1035"/>
            <end position="1117"/>
        </location>
    </feature>
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        <location>
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            <end position="578"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="922"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
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        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
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        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
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        <location>
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            <end position="274"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1095"/>
            <end position="1104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ92780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1199" mass="132288" checksum="7D92D98617BAB0F9" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFU8</accession>
    <name>Q2HFU8_CHAGB</name>
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        <recommendedName>
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        </recommendedName>
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        <name evidence="5" type="ORF">CHGG_00906</name>
    </gene>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001220126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFU8"/>
    <dbReference type="GeneID" id="4386384"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00906"/>
    <dbReference type="eggNOG" id="ENOG502SB54">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065618_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HFU8"/>
    <dbReference type="OMA" id="NQTMSSA"/>
    <dbReference type="OrthoDB" id="5589325at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209225" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="24"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="110"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ92671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="203" mass="21359" checksum="46AC600B2A8C8CFA" modified="2006-03-21" version="1">MKFSFGTVLALAAAVLAQPKFTNSNFEVEEGEPFTLTWNNAEGPVTITLVHGPEKNLQPVTVLTTSGSDGSFTWTPSDLPSDTYAFEIIDDTGVKNWSQRFQYTGTGSVTSTEAPTSTAESSTSTEASSTTTSSSSSSETESTTTSEEASSTTFTTSTTEEAETSTRATTSPTGSPPDLNNGQRFASPLGFVLVTVAALVFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFZ5</accession>
    <name>Q2HFZ5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_00859</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220080.1">
        <property type="nucleotide sequence ID" value="XM_001220079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFZ5"/>
    <dbReference type="GeneID" id="4387339"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00859"/>
    <dbReference type="eggNOG" id="KOG2615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_54_5_1"/>
    <dbReference type="InParanoid" id="Q2HFZ5"/>
    <dbReference type="OMA" id="PWKELQP"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF8">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="15"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="488"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="497"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ92624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="565" mass="61242" checksum="C97323E3D643BFCC" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGD7</accession>
    <name>Q2HGD7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">General transcription and DNA repair factor IIH subunit TFB5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_00717</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the 7-subunit TFIIH core complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TFB5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219938.1">
        <property type="nucleotide sequence ID" value="XM_001219937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGD7"/>
    <dbReference type="FunCoup" id="Q2HGD7">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HGD7"/>
    <dbReference type="GeneID" id="4386739"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00717"/>
    <dbReference type="eggNOG" id="KOG3451">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166246_3_1_1"/>
    <dbReference type="InParanoid" id="Q2HGD7"/>
    <dbReference type="OrthoDB" id="354at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006294">
        <property type="term" value="P:nucleotide-excision repair, preincision complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1220">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035935">
        <property type="entry name" value="TFB5-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009400">
        <property type="entry name" value="TFIIH_TTDA/Tfb5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06331">
        <property type="entry name" value="Tfb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01395">
        <property type="entry name" value="Tbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142897">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ92482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="87" mass="10113" checksum="A92A4DB9CF55B51B" modified="2006-03-21" version="1">MVKAVRECEPAIKSILVHIDSTHHHEFIIEDLDDTHLFVKEAMLQVLKSKLEEVSLVFLRLLPIEADCCGQRLRETYRPDEPLEDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGT8</accession>
    <name>Q2HGT8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219787.1">
        <property type="nucleotide sequence ID" value="XM_001219786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGT8"/>
    <dbReference type="GeneID" id="4387129"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00566"/>
    <dbReference type="HOGENOM" id="CLU_2249817_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGT8"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="104" mass="11086" checksum="8D0E45009364E810" modified="2006-03-21" version="1">MSGSSNEFPLAQLQCWTIIGPSELSRLEPNCPGTRLWQPIGVQGRIKTVQNIAFWATTTGAEHVSQPERDNPALAGATEDAAAMHPAPPFLGLDFSTHSTVGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHK8</accession>
    <name>Q2HHK8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219517.1">
        <property type="nucleotide sequence ID" value="XM_001219516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHK8"/>
    <dbReference type="GeneID" id="4386549"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00296"/>
    <dbReference type="HOGENOM" id="CLU_541841_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHK8"/>
    <dbReference type="OrthoDB" id="4583791at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="503" mass="55780" checksum="C2F25C3132F192CC" modified="2006-03-21" version="1">MAAVPGPPKRKVNKSPQKLTADILSCKVPTYYNVGKAWNVLGYYGAPRPTLQNFVDDVSALWDHQTTLKTPKGRKARAYMLDALRTLGFRNPAFHTERAPLRLEVGDQDGSWGALPAPFRGGNNYGKRDAREYLAAVAPRATPNEPGRRSIIERAILLPDFHLFYGRRAANSRGRYFIYRRHRLENGKPVGGSSLWHYWVVKARIWTYFMQVLKDPSHELWAEYHLMQHLSKTVDPNFGTLSMARSLYAAPSQGKAAYPHEDLLHVIADYFDTKIQVYTSEATERHIDQYDLPVHATFYGRRPGGSSYPHILLARTRAGTQYSIVEPDTHPLHQTPGFSAAHPSPPNLPAHAHYQRDHEGGTPPPIPGRHNRNSRIPHPAPRNAHPPCEQARYNYFAPARPPGDGARGARAWRHPAGDASAAYGVVSGARRVLKQCGGSAALIFVSGAMGVCDERLSLGRSSTRCPYGCQLSAPCASLGAYERVFNSAVRGARIAFEPAFLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI17</accession>
    <name>Q2HI17_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219358.1">
        <property type="nucleotide sequence ID" value="XM_001219357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HI17"/>
    <dbReference type="GeneID" id="4387920"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00137"/>
    <dbReference type="eggNOG" id="ENOG502RKJN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_633129_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HI17"/>
    <dbReference type="OrthoDB" id="5429569at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="433" mass="46362" checksum="19E425D3771806E4" modified="2006-03-21" version="1">MTPHAAMPPNPWLLDLTGSLLACGQVGPRTDAARNAKILNRTGWRLPGGGMKSPLITGLHRGMFVVPYASRHHLNSSTPPAVSSIERQFTTGVSGTMAAFPAAAPLIVSASPTLVRWVTVAVAGIPTALLAADAIPKIREHIQGTSQPDNRVEPAPLEPPARKSESESGPCPAPTFEAEAHSNQVTSNTASIATTSEARAASTNEARAATSPDAVMPDAFELRPSRAARSVSVTYEEGGSWRIELPFPWSIGVAAGYLLYTAFASSNPRSPAAGDSTISSAPRSRSSPPAPSKTTVNARGATVTPPTPPSEDGSDSDEYPEAGRKELKKLLEAEGKEIYEKLKATANTDHSPGASRKVWKNKDFRIDNGHRDDKRGVRHWEFQVNGDAQSTTAKRIRGGSRRGTHQKLFKDTFELKNPPGFEEWKTRVMALLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI60</accession>
    <name>Q2HI60_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219315.1">
        <property type="nucleotide sequence ID" value="XM_001219314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HI60"/>
    <dbReference type="GeneID" id="4388319"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00094"/>
    <dbReference type="HOGENOM" id="CLU_1156259_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HI60"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="240" mass="25982" checksum="0D23F57AF6B45C99" modified="2006-03-21" version="1">MSSAGCELTPMRQGLKRARDSGVPRIQAYPGFRRAQGVKPVVPMFDEPKKIALRMLALIQAAVSDAVASNRELPVKRRFDGFAAAGTKSVRISRNGGCDTIKGAMQRPADMTTYRATPPLAACSLPVRSASDASSACHHQTNGTVSLGVTASPKQFPKRATITSHVAALTMWGIRGLVCWSPPRQNSAMQELERKAAASRLDRPNIKTSPRKDSKEGDDSYDGEQILSRSRIMALPIHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HIA8</accession>
    <name>Q2HIA8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_00046</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219267.1">
        <property type="nucleotide sequence ID" value="XM_001219266.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4386546"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00046"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_31_0_1"/>
    <dbReference type="InParanoid" id="Q2HIA8"/>
    <dbReference type="OMA" id="ALDSLYW"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF13">
        <property type="entry name" value="POLYKETIDE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="8">
        <location>
            <begin position="4"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="9">
        <location>
            <begin position="911"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2058"/>
            <end position="2135"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="911"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1050"/>
            <end position="1202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ91811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="2137" mass="235191" checksum="E931F9B89019A5C5" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM89</accession>
    <name>Q2GM89_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226182.1">
        <property type="nucleotide sequence ID" value="XM_001226181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GM89"/>
    <dbReference type="GeneID" id="4397295"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10915"/>
    <dbReference type="eggNOG" id="ENOG502RZ1N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025462_2_1_1"/>
    <dbReference type="InParanoid" id="Q2GM89"/>
    <dbReference type="OMA" id="TYRYPIQ"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ83097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="271" mass="29502" checksum="326562082C2C1993" modified="2006-03-21" version="1">MALQTSTPSSLILLDTNYLTRITARRALLTTHPRTVLGVLRPAGHAPVHELYTYLLGTYLPARYPTLFQVTTSRDPSTAPHTVRVGFRNCVTGRTAPLYPGLAGAEEMLTVLGETVEDDLFLLLPEGVGGGKGGAHRLVAFVCCHPSGFDPVEKLGKRLAGIHEPVPGYEKIAGSMERYFARLQWSIQTHPHLFAPSGNHIHSGEEVDEEADIDIEKIKEEGLGPELADAIEGLKAGNAPGMWRYKGAVRWGTAVCEYLRAEGKNERPTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMQ4</accession>
    <name>Q2GMQ4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">enoyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="11">1.3.1.104</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_10750</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.104"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.104" evidence="11"/>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ82932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226017.1">
        <property type="nucleotide sequence ID" value="XM_001226016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMQ4"/>
    <dbReference type="STRING" id="306901.Q2GMQ4"/>
    <dbReference type="GeneID" id="4397166"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10750"/>
    <dbReference type="eggNOG" id="KOG0025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_17_0_1"/>
    <dbReference type="InParanoid" id="Q2GMQ4"/>
    <dbReference type="OMA" id="PPTAWIM"/>
    <dbReference type="OrthoDB" id="7482721at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="14">
        <location>
            <begin position="36"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ82932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="394" mass="41014" checksum="5B63D5E4973C6080" modified="2006-03-21" version="1">MAQSLVYTTTPGSGSSTLLVSHAIPSYPSLSASASAVDPTSTASDAGQGKGEEGKDEGEVLVRFLAAPVNRVDLMLLAGRYPIKPKYTAPSPDGTTRHPIPGFDGCALVQSSSTPLFAPGDLVLPGDLGLGTWRTHAVLPASALIKLPAGVDPIDAALIRSGALIARLLLDEVTPLRAGDWVIASAGTSGVSQFLVQLARQRGVKVVLVVRDRGEPVLAVVKAELRALGADAVLSEGELEAELAARSSKAPGPSAAAGLLPKEPIVLALDSVFGRVGQLLASALAPGGKFVLVGLLAGPTATVTVTTDHLFTRQLSFLPFRGSEHLKRLGNARAEELIYETANMFIDGTLKRPTVNVVDWTTAGEGEVEEALKRAIQLASGKEVGHIKTVWRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN67</accession>
    <name>Q2GN67_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_10587</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228514.1">
        <property type="nucleotide sequence ID" value="XM_001228513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN67"/>
    <dbReference type="STRING" id="306901.Q2GN67"/>
    <dbReference type="GeneID" id="4396735"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10587"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_329547_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GN67"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="450"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="483"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="529"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="562"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="595"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="628"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="661"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="727"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="760"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="833"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="221"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="291"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="372"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="333"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ84183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="871" mass="93837" checksum="44173E3F8678EC9F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNM4</accession>
    <name>Q2GNM4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228357.1">
        <property type="nucleotide sequence ID" value="XM_001228356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNM4"/>
    <dbReference type="GeneID" id="4396926"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10430"/>
    <dbReference type="HOGENOM" id="CLU_1777217_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNM4"/>
    <dbReference type="OrthoDB" id="2420947at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02178">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="146" mass="15837" checksum="4B7F55665F465DF1" modified="2006-03-21" version="1">MKAPSEPNQKRKRGRPPGTSSALAREPRDGVIAEPADHGNVAKSEVVPKKRGRPRKSIDPVTQDEQDPALNQADPGETSNMAPKKRGRPPKARDPQAEEEISQETRPRKRRRAGELEEREGSPGEGEGSKKSKSVKGPTDGPPQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNV1</accession>
    <name>Q2GNV1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_10353</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228280.1">
        <property type="nucleotide sequence ID" value="XM_001228279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNV1"/>
    <dbReference type="STRING" id="306901.Q2GNV1"/>
    <dbReference type="GeneID" id="4397050"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10353"/>
    <dbReference type="eggNOG" id="KOG2741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_7_2_1"/>
    <dbReference type="InParanoid" id="Q2GNV1"/>
    <dbReference type="OMA" id="HMSLYHL"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF115">
        <property type="entry name" value="DIHYDRODIOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="10"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="150"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ83949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="393" mass="42703" checksum="9BBA4D80B206D80A" modified="2006-03-21" version="1">MASSTPYTVRWGIMATGWIAEVFTKDLLANPALRDVHDVRHEVAAAASSSSEERAADFLTKVKAPSSAKAYGSYHELVADPDIDIVYVATPHSHHFQNAMLALEAGKNVLCEKALTVTASQARKLVDTARAKGVFFMEAVWTRYFPLSIQVRNLISSGAIGNVYRTIADLSIGKDGADGKIDFDDSHRMVNPALAGGALLDLGIYALTWVFQTLYHVQPEEQKEAPNVVAAVNKYHTGADETTSIIVQFPKHKSHGIALTSLRVSSDVDGKNSGGAAIRIQGSAGEIQVMGPAYCPLQYRVIKKDGAGEVQVVDCPIPKDPESGWGQGMFWEADECARCLRDGQKESKSLPWSESIAIMEVMEETLRQGEVVYSDVITTDVYDAQSPLNTGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPE6</accession>
    <name>Q2GPE6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228085.1">
        <property type="nucleotide sequence ID" value="XM_001228084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPE6"/>
    <dbReference type="GeneID" id="4396614"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10158"/>
    <dbReference type="HOGENOM" id="CLU_2812125_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPE6"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ83754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="67" mass="7411" checksum="E7822563CA414BA7" modified="2006-03-21" version="1">MFDAEVVIRTTPHIPPPTGHKHTHRISSTIYSHPAAPHVRVRVRVRVRVCVCVCVCPCHGPPEARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPG1</accession>
    <name>Q2GPG1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit protein mS37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the mitochondrion-specific ribosomal protein mS37 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228070.1">
        <property type="nucleotide sequence ID" value="XM_001228069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPG1"/>
    <dbReference type="FunCoup" id="Q2GPG1">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GPG1"/>
    <dbReference type="GeneID" id="4396148"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10143"/>
    <dbReference type="eggNOG" id="ENOG502SBQ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162186_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPG1"/>
    <dbReference type="OMA" id="INYHAAR"/>
    <dbReference type="OrthoDB" id="2210at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017264">
        <property type="entry name" value="Ribosomal_mS37_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28066">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28066:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037706">
        <property type="entry name" value="MRP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="92" mass="10146" checksum="02F820174DA155DC" modified="2006-03-21" version="1">MSTKNPIRLPPLRVLRVRNPNRSESNPCVTVMSSVLACWASAGYHGRGCTTVEQALRACMDAPPPPKKGSNTINYHLARFSKRLIAQGKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPU7</accession>
    <name>Q2GPU7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227934.1">
        <property type="nucleotide sequence ID" value="XM_001227933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPU7"/>
    <dbReference type="STRING" id="306901.Q2GPU7"/>
    <dbReference type="GeneID" id="4396234"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10007"/>
    <dbReference type="eggNOG" id="ENOG502QQBX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1001165_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPU7"/>
    <dbReference type="OMA" id="GEHELPI"/>
    <dbReference type="OrthoDB" id="4575146at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ83603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="278" mass="30537" checksum="9CFA99861D92E65A" modified="2006-03-21" version="1">MTSEATSESLTQTGRPFQNVLQLWKGRIPLPSFSLGEHSYGFGWAGAQLPGILAPGDNGPDDLNPMVGIGAPPKLAVYHGGDIAGFSTYNALFPASGSAVVVLTNSLLRNNGVRWIGELLIEALFNNSHNAQDYQVVAKKAAESAVQRFQDTSKSLAAGRTVEQPNRPLNAYIGDYHNLGGNFFIQVRFNEKRDGLLIAYMGREADTFELVPYQADSFYWTLTYDDTVKLGREVVYPEEYYIVKFGLAIEEPGEMFKKAGGSAVVEMWEDLEVNLVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQ37</accession>
    <name>Q2GQ37_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_09917</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227844.1">
        <property type="nucleotide sequence ID" value="XM_001227843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQ37"/>
    <dbReference type="GeneID" id="4396499"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09917"/>
    <dbReference type="eggNOG" id="ENOG502SRWG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042941_2_2_1"/>
    <dbReference type="InParanoid" id="Q2GQ37"/>
    <dbReference type="OMA" id="LEPEIMH"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF7">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ83513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="30938" checksum="C00B7642D8F7ECCB" modified="2006-03-21" version="1">MKKSKNVEEEYTPVRNSMSEDSKDGLLHKERIEAYERPRTFWSRNGRFILIQVALLVLYTAAAFLISARASGRCLRGQPLSHSPASDAVVWEERRFVLGDRIQEKGIYSGKPRPELDKAWHDLLNAENIRLEPEIMHRLGRENIGVRIPGEDGYIGTLNVYHELHCLYMYQDIYYPGISDSDREMNRLHNEHCIDFLRQSAMCHGDVGLITFEWHPKQRIPVANATTHQCVKWDILDRWTKERSVDMLKPNWLVHPTLVVKFGEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQE4</accession>
    <name>Q2GQE4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidoligase enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227737.1">
        <property type="nucleotide sequence ID" value="XM_001227736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQE4"/>
    <dbReference type="GeneID" id="4397074"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09810"/>
    <dbReference type="HOGENOM" id="CLU_799259_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQE4"/>
    <dbReference type="OrthoDB" id="4571558at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022025">
        <property type="entry name" value="Amidoligase_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12224">
        <property type="entry name" value="Amidoligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="38022" checksum="24CB5B524FF1B5F6" modified="2006-03-21" version="1">MAGKMLTKSNTGGVEIISPPIAASSNWQRTIHRVFRAVCEQFDLWTNDLCACHVHVSLGPDPKGEFGRKDLVKFGKGTYFWEEALKGLLPYARHENRYAVANHLRYGEKQYKNVPTKGWEPVFNLITAPMEADVRKHKDNFINALNGGTTGAAVKYMSTNFQAYLRIKTVELRRQAGAASATTTIFRALLAVTFNISALEYRFPSASKEYPSTQTLIAELVRCMHTLPQESHHPNFEAWLKQCATTYARESKSRTAYTVGQTNTREMDLRIREGSEHALAPAASSSAAPAAAQAAPKKTGKAAASSAAPAAAAQPSTSTLPVRTVGSGGVSYSRQYTLDDVNFSNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQH4</accession>
    <name>Q2GQH4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein S-acyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_09780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.225" evidence="1"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227707.1">
        <property type="nucleotide sequence ID" value="XM_001227706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQH4"/>
    <dbReference type="STRING" id="306901.Q2GQH4"/>
    <dbReference type="GeneID" id="4396715"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09780"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_839370_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQH4"/>
    <dbReference type="OMA" id="RCHNIEE"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="215"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="248"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="281"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ83376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="331" mass="35900" checksum="827812D745FC8488" modified="2006-03-21" version="1">MVAVCAGLVVVDEESGIIRLVHYTAQEYFKWAQTQRKWFPDAERDIAVACVTYLSFDIFSTGRCHNIEELWERLWSNPLYRYASSTTTALHLASYFGIYDAVASLLPSWQDVDLAGTRGWTPLSYAAVGGHAVVIRLLLDKGADADRTVSFSTPLYWAAKNGHMAAMRVLLEKGADVNAISRGQTPLSISAKVGNADARRLFLNNDAVVDMKDDNGRTPLSHAAASGYEGVVRLLIENNAAVDMADEEGLTPLGHAAASGQQVVVRLLVDKGAAINTKEIEAVAPLLVTAYEGHEGIIRLLLDKGGEVEMTDPSDKTPLLLASEYRHGAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GR38</accession>
    <name>Q2GR38_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227493.1">
        <property type="nucleotide sequence ID" value="XM_001227492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GR38"/>
    <dbReference type="GeneID" id="4395088"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09566"/>
    <dbReference type="eggNOG" id="ENOG502SP9Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1085865_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GR38"/>
    <dbReference type="OrthoDB" id="3481585at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="256" mass="29978" checksum="57D941A6877F094C" modified="2006-03-21" version="1">MMFDNHALLRRPYRKPPPGSVEANRATVTDWEPLEPSARWRRIQGSARVSEAERKSWVRIIQSSREGLSSETSPTSLGYQAHDDIDKKAQKYIVGTGRQKRRCIECQRQSGLLARDQLRPSGFPPVHPREFTAVKWPELHAFAEPDLFNFKGLYYPEKPEDPLLCHDCRFESCQGRSLLTQKFSTKVLDRLQDIRRRLESMIRTGWNIQYPVMRIWVEDYPLADAMYHWVCNQIAWIENNPNAALNSVLNDKRYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GR89</accession>
    <name>Q2GR89_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_09515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227442.1">
        <property type="nucleotide sequence ID" value="XM_001227441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GR89"/>
    <dbReference type="GeneID" id="4395616"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09515"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001248_0_2_1"/>
    <dbReference type="InParanoid" id="Q2GR89"/>
    <dbReference type="OrthoDB" id="5095382at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF6">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="336"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="843"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ85501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="873" mass="95645" checksum="59610712F8EA9030" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRB5</accession>
    <name>Q2GRB5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="6">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_09489</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="6"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227416.1">
        <property type="nucleotide sequence ID" value="XM_001227415.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4395917"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09489"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_238363_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRB5"/>
    <dbReference type="OrthoDB" id="5095382at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="8">
        <location>
            <begin position="719"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="9">
        <location>
            <begin position="1253"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="871"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1154"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1759"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1156"/>
            <end position="1170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ85475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1790" mass="200152" checksum="62454EAB3A5089F9" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GS25</accession>
    <name>Q2GS25_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_09229</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="10"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227156.1">
        <property type="nucleotide sequence ID" value="XM_001227155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GS25"/>
    <dbReference type="FunCoup" id="Q2GS25">
        <property type="interactions" value="1082"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GS25"/>
    <dbReference type="GeneID" id="4394659"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09229"/>
    <dbReference type="eggNOG" id="KOG1885">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008255_6_0_1"/>
    <dbReference type="InParanoid" id="Q2GS25"/>
    <dbReference type="OMA" id="DFRNEGM"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000050">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000238">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="266"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ85215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="618" mass="70658" checksum="FA447BA54EA81B04" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSI7</accession>
    <name>Q2GSI7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226994.1">
        <property type="nucleotide sequence ID" value="XM_001226993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSI7"/>
    <dbReference type="STRING" id="306901.Q2GSI7"/>
    <dbReference type="GeneID" id="4395327"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09067"/>
    <dbReference type="eggNOG" id="ENOG502RZFD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_546273_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSI7"/>
    <dbReference type="OrthoDB" id="5404323at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="499" mass="54197" checksum="6B1DD5C81AAF2084" modified="2006-03-21" version="1">MFLHSGASLHGHEYSNRPSSKIQSPAHLRGPLLRSTFPPPKQRARASTDGTPPPALRQRPASDYIPRSPSPVVRFQDPQDGPPPTPSTHDDSVSESELSDVTHSIDGTLFARTARHRRPRRTRRQSTTYYLGYPTPRIIGKTKVGRSKPVLEVFPASRIAGPVVAPRLAKRFPGIFGVKRHLGYDDLVLVRRDDGDAGSDSMECENEENLEGRNLLAVYSPLRHSEEAEIVLDDGSVWVARPLPNGSFDFVHTDADGKTTTARWARRHTAAVSPTTDTSASSTAPQTRYTFSIINPLTRRHPVMATLTPSTLDVQDTYISVSPSHARHPPITRVGRSQSVTTPPSFVRAPYSPSKLSSSASTSDGENDSGVYIPPSPDRESQRTIHQIDDTTKTLISVTALWPRQAKHLDHPLLDLRRPPPRRPPPNLETTHSALLHAKASYTTTTTNATPCPTPPPSPTPTPPLSVCVSRNLSPSPDPNPDAQAVGSPGGGDGATNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSZ7</accession>
    <name>Q2GSZ7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226834.1">
        <property type="nucleotide sequence ID" value="XM_001226833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSZ7"/>
    <dbReference type="GeneID" id="4395453"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08907"/>
    <dbReference type="eggNOG" id="ENOG502RXW6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033263_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSZ7"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36459:SF1">
        <property type="entry name" value="FATTY ACID DESATURASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36459">
        <property type="entry name" value="ORF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="44426" checksum="3AA5CDB4E72DBC94" modified="2006-03-21" version="1">MEEIIYSPELTIPDTLLLRNLADDIQRHKEIKGASSKVDRDEGYSSTGSGRSAENAINKYGISEERDASDIQKLNGFNDHESKDFEPTVISSLDLADLQAKLPAVVYQNVVLPYIAWARTIVRHDTDVLMLTHLIMYFTTSLPSAIWLFYNFTYLHGIFHFVMQFWYMGTYTLMMHQHIHMGGILAKRPLLRLFDTYFPYVTDPLMGHTWNTYFYHHVKHHHVEGNGPDDLSSTLRYQRDELLHFLHYIGRFLVLIWLDLPLYYLRKGKYANAARAAFWELSNYTAIYMMYQLNSRAATFVFICPLTLMRIGLMVGNWGQHAFVDADEPDSDFRSSITLIDVPIDLTLDERAEMLRRHTRRFGEEEIKVKFAASAAAAATGKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTU7</accession>
    <name>Q2GTU7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_08607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226534.1">
        <property type="nucleotide sequence ID" value="XM_001226533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTU7"/>
    <dbReference type="GeneID" id="4395809"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08607"/>
    <dbReference type="HOGENOM" id="CLU_2133227_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTU7"/>
    <dbReference type="OrthoDB" id="10416910at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="113" mass="12564" checksum="2D3225054B8EE350" modified="2006-03-21" version="1">MGLDYKLDFQFPRGPIHLPDITEAFATLPISLIKSINVEDYSLHRITVEEPEDMVKLFFEELQIALGPSSPGRKWSASHVLAAWKHTSNIETGDINTSISECGGLVNLAKRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTZ3</accession>
    <name>Q2GTZ3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_08561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226488.1">
        <property type="nucleotide sequence ID" value="XM_001226487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTZ3"/>
    <dbReference type="GeneID" id="4395266"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08561"/>
    <dbReference type="eggNOG" id="ENOG502SWKZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_677934_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTZ3"/>
    <dbReference type="OrthoDB" id="5233753at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="45100" checksum="96689B191AB294A5" modified="2006-03-21" version="1">MQPTSLSGDVEVFDPRGDLKLIVGSDQIAFQVCSRALARSSKYWETMLYGAFAEGQGQQEAGSDWVIPLPEDRPEGLRILCLAVHGRFDALPGKITHGELLYLTVLADKYNMISSLKPFWKGWLKELDYITDSTPAADELLDYLSVCYKLGYGRGFRKAFVYVVKCAAAHGDGRLYIDGDQDHDIYGDDHVWLRDKVLGQTPFAGGDVLNESDADPNVEGVRRGREIVLTIICTKIQRGILSLIFESGCTAETPSKVCNCTMLGSLVRAMASRKLDRWFNDRMEGVADSITSCVSDFSSLLAELREEAVAARESFDWEHGECRPWASESEKMGDEGMDALYEIIYEFAADLEGEAKKSGLNPDNPARFSTPVPCQEIAELVVDEDQGIPLLDNGLLYETEVRYLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUW0</accession>
    <name>Q2GUW0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein RO7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225900.1">
        <property type="nucleotide sequence ID" value="XM_001225899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUW0"/>
    <dbReference type="STRING" id="306901.Q2GUW0"/>
    <dbReference type="GeneID" id="4393647"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08244"/>
    <dbReference type="eggNOG" id="ENOG502S8RP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023246_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUW0"/>
    <dbReference type="OMA" id="GDYRGWI"/>
    <dbReference type="OrthoDB" id="337660at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ86991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="573" mass="62825" checksum="A4942E697105E741" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV03</accession>
    <name>Q2GV03_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CHL4 family chromosome segregation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225857.1">
        <property type="nucleotide sequence ID" value="XM_001225856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV03"/>
    <dbReference type="STRING" id="306901.Q2GV03"/>
    <dbReference type="GeneID" id="4393522"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08201"/>
    <dbReference type="eggNOG" id="ENOG502QVRZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031572_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GV03"/>
    <dbReference type="OrthoDB" id="6585699at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007902">
        <property type="entry name" value="Chl4/mis15/CENP-N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05238">
        <property type="entry name" value="CENP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="42914" checksum="E681B551BFECA0DF" modified="2006-03-21" version="1">MTRISVPTTARLPSALRVDPTNPTATKILGRLSRSSLISVALDWLDENNLPLALPYLRENRGEYEDEDEDEDEDHDTGDFHPPARSLEALRELYTSLQARKGSKREVLDRIIEGDWRHGLTLYQLAMADLQYLYDHPTSQKWSAYRIAPLKPPRDPDGEEPSEVDDKSLTIPRFHPSTFLRTLQSHVLPDVKAHYNFDTHKTLPLLILRIFILDSPYNTEHALKTTTTAFNASRTVYIAFPDASPHLFLSKPTTTTTTTPSLNPPNPNPNPNTPLGETKSLHHLLLAGLPKALSNPLWGEFTGCYPPELDTRNLADLVARRRGGRTKVPGGGWSVYADEGKGVVGREIMNRQAIVAGRNPSFFSIASPRICKVLASDAVIRSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVQ1</accession>
    <name>Q2GVQ1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exportin-1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_07953</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225609.1">
        <property type="nucleotide sequence ID" value="XM_001225608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVQ1"/>
    <dbReference type="FunCoup" id="Q2GVQ1">
        <property type="interactions" value="1284"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GVQ1"/>
    <dbReference type="GeneID" id="4394240"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07953"/>
    <dbReference type="eggNOG" id="KOG2020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011906_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GVQ1"/>
    <dbReference type="OMA" id="WAFKHNN"/>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000490">
        <property type="entry name" value="CRM1p Major karyopherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Exportin-1 C-terminal" evidence="8">
        <location>
            <begin position="689"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ86700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="982" mass="112262" checksum="34C7C8BD92802B61" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVU6</accession>
    <name>Q2GVU6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">General transcription and DNA repair factor IIH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_07908</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the GTF2H2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225564.1">
        <property type="nucleotide sequence ID" value="XM_001225563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVU6"/>
    <dbReference type="FunCoup" id="Q2GVU6">
        <property type="interactions" value="889"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GVU6"/>
    <dbReference type="GeneID" id="4394370"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07908"/>
    <dbReference type="eggNOG" id="KOG2807">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028556_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GVU6"/>
    <dbReference type="OMA" id="INWVEVP"/>
    <dbReference type="OrthoDB" id="284275at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01453">
        <property type="entry name" value="vWA_transcription_factor_IIH_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000015">
        <property type="entry name" value="General transcription factor IIH subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004595">
        <property type="entry name" value="TFIIH_C1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07975">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015919">
        <property type="entry name" value="TFIIH_SSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01047">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VWFA" evidence="13">
        <location>
            <begin position="103"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="432"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR015919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ86655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="463" mass="49600" checksum="991170A3C8DA445F" modified="2006-03-21" version="1">MADSDGEYVGDLSDDELGDPRVASAADGSSYGTRSKAGRGNGKGGDGRKGGRSKAAWEDIKRSWEHVVETEDGSITVGALLEAEKRRRLMRDTTPFQRGIIRHVMLVLDMSFAMAEKDLLPNRYLLTLNYAVDFVREYFEQNPISQLGIVGMRDGIAVRISDMGGNPAEHIEKLRVWAEQQEPQGNPSLQNALEMCRGALFHTPSHGTREILIIYGALLSSDPGDIHDTITNLLADRIRVSIVGLAAQVAICEQLCSRTNGGDPSNYAVALHEQHFRELFLAATTPPVCRLPAECPVCALTLVLSTHLARSYHHLFPLRGWAAVSWADARARGSSACFACLAAFPAVPPSGQIQTQTQVQANGNGNGNGRDTDRDKGRDAAEVKAAAGVSESGRYACTVCNNHFCIDCDVFAHEVIHNCPGCQSDTRGTEGLQAADGSSGGEVVNGNGQALGNGASEAMVLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GW70</accession>
    <name>Q2GW70_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="10">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_07784</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="10"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225440.1">
        <property type="nucleotide sequence ID" value="XM_001225439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GW70"/>
    <dbReference type="FunCoup" id="Q2GW70">
        <property type="interactions" value="1071"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GW70"/>
    <dbReference type="GeneID" id="4393929"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07784"/>
    <dbReference type="eggNOG" id="KOG0376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_5_2_1"/>
    <dbReference type="InParanoid" id="Q2GW70"/>
    <dbReference type="OMA" id="IHKKYAF"/>
    <dbReference type="OrthoDB" id="445564at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07417">
        <property type="entry name" value="MPP_PP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000389">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041753">
        <property type="entry name" value="PP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058209">
        <property type="entry name" value="TPR_BSK1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25575">
        <property type="entry name" value="TPR_BSK1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="11">
        <location>
            <begin position="253"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ86531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="453" mass="51252" checksum="0F87707BF4D0B148" modified="2006-03-21" version="1">MATPEEKATDLKNQGNKAFAAHDWPTAIDLYTQAIELNSKEPTFWSNRAQAYLKTEAYGFAVRDATKAIELKPSFVKAYYRRATAYAAILRPKEAVKDFKTCVKIDPGNKDAKLKLVECEKIVRQLAFFAAIEVGDEPSAAEGLDVDSIAVEPAYDGARLEGEMTQEFIDDMTERFKNGKLIHKKYVYQIILAVKKLVYDEPTMVEVDIPEDVQLTVCGDTHGQYFDLMELFRLNGTPGDKHCGLRPKNFFINRGNHETDDMNRVYGFEGECKAKYNERVFKLFSESFSALPLATLIGKKYFVLHGGLFSDDNVTLDDIRKLDRHKQRQPGQAGLMMEMLWTDPQTEPGRGPSKRGVGMQFGPDVTKRFCEKNGLEAVIRSHEVRMGGYEEEHDGKCITVFSAPKYCDMTENRGAYINIGPDYKLKFTQFDAVPHPNIRPMAYAQNSVMSSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWS7</accession>
    <name>Q2GWS7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_07577</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225233.1">
        <property type="nucleotide sequence ID" value="XM_001225232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWS7"/>
    <dbReference type="STRING" id="306901.Q2GWS7"/>
    <dbReference type="GeneID" id="4393964"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07577"/>
    <dbReference type="eggNOG" id="ENOG502QYWX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004083_5_2_1"/>
    <dbReference type="InParanoid" id="Q2GWS7"/>
    <dbReference type="OMA" id="WGTEIFG"/>
    <dbReference type="OrthoDB" id="2269373at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ86324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="621" mass="69535" checksum="416FC971C32676CE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX42</accession>
    <name>Q2GX42_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_07462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225118.1">
        <property type="nucleotide sequence ID" value="XM_001225117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX42"/>
    <dbReference type="GeneID" id="4393578"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07462"/>
    <dbReference type="eggNOG" id="ENOG502QR4T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_1_1"/>
    <dbReference type="InParanoid" id="Q2GX42"/>
    <dbReference type="OMA" id="CPELKMR"/>
    <dbReference type="OrthoDB" id="4589250at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="87"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ86209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="333" mass="37698" checksum="F4FF8D3C96C80577" modified="2006-03-21" version="1">MANHLLRTRGAPPVGKLWAHRFVKRQPRLSTRRTRRYDYQRAKCEDPKVIGEWFALVQNTRAKYGIVDDDVYNFDETGFMMGMIFPVGLDWIKHFDYHTAPRTKGIYRLLILDGHESHHSTEFELYCRDNKIITLCMPPHSSHKCQPLDVGCFGPLKQAYGRYVEELMRAHINHISKLEFLCAFREAFFASMTEKNIQGGFAGAGIVPFDPERVLSKLDIKLHTPTPPNSRPGTAQPWVSKTPHNPQEASSQSNLIKTHIASHQNSSPASMLAAVDQLTRGTTAVMHQVALLQSEVSSLRKANEALSKRRRAKKTRVQLGGSLTVQDAQDLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXB6</accession>
    <name>Q2GXB6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Beta-xylanase</fullName>
            <ecNumber evidence="11">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_07388</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="11"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225044.1">
        <property type="nucleotide sequence ID" value="XM_001225043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXB6"/>
    <dbReference type="GeneID" id="4394600"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07388"/>
    <dbReference type="eggNOG" id="ENOG502QR4K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_769469_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GXB6"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF35">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209100" description="Beta-xylanase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="15">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="19"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAQ86135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="360" mass="37227" checksum="760FC8FECDCE3CAC" modified="2006-03-21" version="1">MARLATALLLASSLASSTTAQNQTQGQGLHSLMNPHKTNSPSPKRTASPRRSSPTANASAATPCTWHSQLPPFVSNGTWTPATLTAVLTAHITTVMQHYAGQCYAWDVVNEALSEDGTLRPSIFLTTLGASYIPLSFTIASRADPTAKLYYNDFNLETTPAKAAGALALLRTIQAARAPIHGIGFQAHLTVGQTPPRANLAALLRRFAALGVEVAYTELDIAHAEGTLPAGEAARERQAGDYVAVVGSCLDLGARGRFRGRGRRVCWTAGMEKKVAYARVVELLRGAAAVVGNGSRGVDGGAGVGMGGSGRGMGPNRTGGVGEAGRPAFMAPPPGFNGAVRVWGGLVGLVVPAVAALVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXC4</accession>
    <name>Q2GXC4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225036.1">
        <property type="nucleotide sequence ID" value="XM_001225035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXC4"/>
    <dbReference type="STRING" id="306901.Q2GXC4"/>
    <dbReference type="GeneID" id="4393529"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07380"/>
    <dbReference type="eggNOG" id="ENOG502RAQ3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_736045_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GXC4"/>
    <dbReference type="OrthoDB" id="5362630at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF3">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="49470" checksum="53FD0841D74CF8CC" modified="2006-03-21" version="1">MPEPSLTLRLLNLDRYPCVTSAAPGRLLWDFPPSPVDQAAAGSLYHWPLTAPTIQPPGPYDQLPSLPTPPILTGTDPHSFAAFPSDSGCPPLAAEQLAGPPRAPGDQGAAYLRFLQGPVDAILLPNGAEPDRVGGYGPPTVFGSYQEPATLHLAPNGSPPAPLDIGLRLSRMYGTVERLEDGNWIKEEPPTPANGDWGVPTPAGVPRNIHPANAVEGPPRPGNGEDDEEASNRKGRRRLNEGLRTETSNTRQIGACIRCHNQRIRCRPNKLDPTNPDAPCESCLLVRKASKKTIHYISCLRFKVTSMVVYRAGGLGYTKRFDHTKIVDVDGYSDGITYDIEITQGLCQTPILLKVRRFRPNQTDKTHWSYRVDDTTCAHRSQDTGAFCLVNIKETAKKFNDYIACNAADGLAEAVKDSDDMVKEVFAMIEKQCRSLPVWNPNLHPLQPPRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYJ5</accession>
    <name>Q2GYJ5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224615.1">
        <property type="nucleotide sequence ID" value="XM_001224614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYJ5"/>
    <dbReference type="GeneID" id="4394437"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06959"/>
    <dbReference type="HOGENOM" id="CLU_900162_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYJ5"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="309" mass="34080" checksum="C150F6AADDAB578D" modified="2006-03-21" version="1">MWFTGFTIDPDTVSLNVPKRPNQDPNDFFRAQKRVRLGEAKSILDPLPAQPPELQSFRDTAHRIRIGQWLDADPFGGEDVDCPPNTPIEVQGASVAPTHQVCENLAGQRNTLDTMRKIRQQVNASGADMREPEAQNMDANEEEQQPSELLSDLLAQARRSDQDRTAEDNGFVDPGEEQGHVEEQTRGGLTDGRSARATSSIPHLAGLELEDTTSTIEDQAAPFNLSPFELAFALWEKKHNISRAAHSHLREVLQLVQHIDELRKNPTAEGYGGTPTTSCPTTRYIMEGDTSGPKRAPQSGVVRQIDAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYP8</accession>
    <name>Q2GYP8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_06906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224562.1">
        <property type="nucleotide sequence ID" value="XM_001224561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYP8"/>
    <dbReference type="STRING" id="306901.Q2GYP8"/>
    <dbReference type="GeneID" id="4393538"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06906"/>
    <dbReference type="eggNOG" id="ENOG502S0Z5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035325_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYP8"/>
    <dbReference type="OMA" id="PGMGFYQ"/>
    <dbReference type="OrthoDB" id="4092340at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ85653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="599" mass="64617" checksum="334CB1D683686765" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYR0</accession>
    <name>Q2GYR0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_06894</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224550.1">
        <property type="nucleotide sequence ID" value="XM_001224549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYR0"/>
    <dbReference type="STRING" id="306901.Q2GYR0"/>
    <dbReference type="GeneID" id="4393218"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06894"/>
    <dbReference type="eggNOG" id="KOG3468">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154847_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GYR0"/>
    <dbReference type="OMA" id="YRDSCAN"/>
    <dbReference type="OrthoDB" id="268414at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ85641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="86" mass="10414" checksum="3195AEE5CD502447" modified="2006-03-21" version="1">MALESDETPRRATREEMRDAKLPLQYRDSCAHLLIPLNRCRFETWYMPWKCEDERHSYEKCQYVEFKKRVAKMDELREAKAGARSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZ61</accession>
    <name>Q2GZ61_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP-dependent DNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_05185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224399.1">
        <property type="nucleotide sequence ID" value="XM_001224398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZ61"/>
    <dbReference type="GeneID" id="4392277"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05185"/>
    <dbReference type="eggNOG" id="ENOG502S808">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1219573_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZ61"/>
    <dbReference type="OrthoDB" id="5103340at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ88566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="24597" checksum="2917259A79F83618" modified="2006-03-21" version="1">MALGKNSIALLAHLAAVKEFSLYCCSGAHALFLVRNSGVLDSGGGVLAKASLHDMFRLKDGLHTLLLTGASGNAAALIGGVTLHSATNIGFEGKNEVARNVSEEEKLRWKNMVMLIVDEISQGPRRTEIREGCKAPSCAQAVPPVHGRRHPPRTDGLRAITPLNQDRWDLNMAAVVQWARAHGKHISIFVAKHDTESGKRLRVEELGDVLRHGDDSQLPTPGLFFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZ70</accession>
    <name>Q2GZ70_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein transport protein BOS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_05176</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the BOS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224390.1">
        <property type="nucleotide sequence ID" value="XM_001224389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZ70"/>
    <dbReference type="FunCoup" id="Q2GZ70">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GZ70"/>
    <dbReference type="GeneID" id="4392538"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05176"/>
    <dbReference type="eggNOG" id="KOG3251">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078260_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GZ70"/>
    <dbReference type="OMA" id="FCWLVIH"/>
    <dbReference type="OrthoDB" id="158360at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15863">
        <property type="entry name" value="SNARE_GS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000054">
        <property type="entry name" value="Protein transport protein BOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027027">
        <property type="entry name" value="GOSR2/Membrin/Bos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF1">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028865">
        <property type="entry name" value="Membrin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ88557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="282" mass="30064" checksum="5CFE3EC0FB8AA57C" modified="2006-03-21" version="1">MNTTFNSALKQRTTIRKDLSALSAHLPTASNSNHDPHQPQPAAPLTPAALGSLSASLTAFARTVDEYNALAKQELNATKQDKAFERIRDFRAELADFRARFDALKAARDDAAHADNRAELLGRRPFAAATPENPYANVGGGGGGGGGGALGVASSASGYGMSGRGHARTTSSAEAGSGGLGMGSGDVTREGHALREQQFFANTHSALDDYIARGQAVLGDLGQQREMLKSTQRRLYSVGNTLGISGDTIRMIERRAKQDKWIFGAGVVVFFLFCWLVLHFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZP4</accession>
    <name>Q2GZP4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_05002</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224216.1">
        <property type="nucleotide sequence ID" value="XM_001224215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZP4"/>
    <dbReference type="STRING" id="306901.Q2GZP4"/>
    <dbReference type="GeneID" id="4391893"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05002"/>
    <dbReference type="eggNOG" id="ENOG502S77Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1626830_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZP4"/>
    <dbReference type="OrthoDB" id="5336366at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051668">
        <property type="entry name" value="ATG33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37278">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37278:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ88383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="163" mass="16831" checksum="D7C4CCAB1324BB6D" modified="2006-03-21" version="1">MAARGVSVLKFVGTVSLGVLTGLSYTLTSLTIPALLTLPSAGSAARAFDILTTTASRHARSLAAGVLLGAAATAAQRRQREKRQREREQRAAAARARMEASYEVLGGFEAHSEGSAEEYEAEEAYVNGEQGQGSGGGVPPESRSCGARCLALGFPALRGGHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZR2</accession>
    <name>Q2GZR2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224198.1">
        <property type="nucleotide sequence ID" value="XM_001224197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZR2"/>
    <dbReference type="GeneID" id="4392349"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04984"/>
    <dbReference type="HOGENOM" id="CLU_676144_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZR2"/>
    <dbReference type="OrthoDB" id="10663236at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="407" mass="43714" checksum="31F54973F5E2EA7A" modified="2006-03-21" version="1">MQSTTIRRRSRRRRSGFISPPVPANNGNGGVQSLSEDDDEGDDRPGLGKGRGKGKGDPDKFPPEPISTSEAIPPSSSLIQPPPTTSDLPTSSTSLEIPESTSPSSISAPAPQTSSHIETQPAYSTTSSIPPIQALNNEHSLRPGQIAGIVVGLLAFVLLTIVSVLFVLRSRRRRAKKYSGQKGLLDSTPATPQPTPYTKHETAEPPTVEDPQLFNTTANSTTEKVIPPTTRLSQWLNQLRHSHIPGTGTGTGTSRKSLPHITIGATSSTPSDTDDSSSILSIPTTFVTRQGRGSNTNSTFLPTTPLHHPRYVTPPAPQPPPPPPPSQRQGAEKQNLQPPPSPLRSSGQSNRMTIFDKRWPAREGRILPPPPLTPTSPWEFFYSLLPSLPTATRLSVAGVCCFPSFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H087</accession>
    <name>Q2H087_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224023.1">
        <property type="nucleotide sequence ID" value="XM_001224022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H087"/>
    <dbReference type="GeneID" id="4392985"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04809"/>
    <dbReference type="HOGENOM" id="CLU_1740305_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H087"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="150" mass="15847" checksum="4DAA86FA1558F9CE" modified="2006-03-21" version="1">MTARGPCDDAALVGAAENLCVDQLLLNLAGDVGEGACLGSSEEPAFGGGSAESMAPRVDSRMDRIPKWPPSPSELCRVQQQQEQQRNNSGASIECCYKLNSLNPEVAEYLQVPPKAMQRVVGLCRRPEGGKSGGGLSRNGPLKKIPPTPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0D7</accession>
    <name>Q2H0D7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223973.1">
        <property type="nucleotide sequence ID" value="XM_001223972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0D7"/>
    <dbReference type="STRING" id="306901.Q2H0D7"/>
    <dbReference type="GeneID" id="4391996"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04759"/>
    <dbReference type="eggNOG" id="ENOG502T09I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_480577_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H0D7"/>
    <dbReference type="OMA" id="YHQANIR"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="62316" checksum="A801C0CB53CB55C2" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0K8</accession>
    <name>Q2H0K8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223902.1">
        <property type="nucleotide sequence ID" value="XM_001223901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0K8"/>
    <dbReference type="GeneID" id="4392255"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04688"/>
    <dbReference type="HOGENOM" id="CLU_1111261_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H0K8"/>
    <dbReference type="OrthoDB" id="10570188at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="250" mass="26916" checksum="B09D24E92A70A007" modified="2006-03-21" version="1">MASGSTALVGPSGGAIADECRASKVDEGGSSNRIDQTLPSWDFGRGGPRVAVRSHQSSLDRRYLSSNCMFRLFWNSSAAPAPRPQTGQAAAPKHAGDRNAVFINRGAEDQSRIGCSLGLVDAAGRRSQEGVLLPPAGVELYVPLRCMLSRAIDRGERSTRLGRRRTKPPPRHFTRSTHAHGRPSHVDQRYISDDLMRSKGARAWTLSRQNTGTAALGPSSCSTSRRDAKAGAYRAVNLRFRPPRGGLGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0N2</accession>
    <name>Q2H0N2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SigF-like NTF2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_04664</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223878.1">
        <property type="nucleotide sequence ID" value="XM_001223877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0N2"/>
    <dbReference type="STRING" id="306901.Q2H0N2"/>
    <dbReference type="GeneID" id="4391787"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04664"/>
    <dbReference type="eggNOG" id="ENOG502S534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079426_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H0N2"/>
    <dbReference type="OMA" id="THIMENP"/>
    <dbReference type="OrthoDB" id="2344312at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057514">
        <property type="entry name" value="NTF2_SigF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35393">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35393:SF1">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24840">
        <property type="entry name" value="NTF2_SigF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="SigF-like NTF2-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ88045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="268" mass="29409" checksum="84401C2587D910A3" modified="2006-03-21" version="1">MEDPAQDIKNVLQALTQGTPEAQHDAIYRYFAPGAAFEHPFCWVPSFKNLNVPFVGEIDSRILIAAIYRWYKILSPKIELELESCVYDERANLLYLTIFQVFSIWFIPFHRAPVRLVTVLHLTPAHAPGDGTPPPTYDAAQEKLQAVLEGNEPSYAAVTGGSAGSQTQRKKKDGNSKPPPTSDAASKATGSGSDSGSSSSTASTRYLIKTQKDLYQVNEFFKFVTLTPLLPIIIGFLQVLATLACWAGETTLGPVMKFVWPAKGKEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0P0</accession>
    <name>Q2H0P0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein kinase RIO2</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Serine/threonine-protein kinase rio2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CHGG_04656</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223870.1">
        <property type="nucleotide sequence ID" value="XM_001223869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0P0"/>
    <dbReference type="FunCoup" id="Q2H0P0">
        <property type="interactions" value="1097"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H0P0"/>
    <dbReference type="GeneID" id="4391733"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04656"/>
    <dbReference type="eggNOG" id="KOG2268">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018693_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H0P0"/>
    <dbReference type="OMA" id="GYTNFRE"/>
    <dbReference type="OrthoDB" id="10258631at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000053">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000052">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="16">
        <location>
            <begin position="67"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="246"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="367"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAQ88037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="425" mass="47740" checksum="98B76212DFD58258" modified="2006-03-21" version="1">MKLDTRAMRYLTAEDWRVLTAVEICSKNHELVPTTLIERTARLKGGASGVHKSISALAKVGLIARMKEAKYDGYRLSYGGLDYLALHTHASRKQVYSVGTRVGVGKESDIMIVADDKGTQKILKIHRLGRISFRTVKTNRDYLKKHQSGSWMYLSRLAAIKEYAFMQALREEGFPVPEPIAQSRHTIVMSLIDAPPMRQIASVPDPATLYAELISLILRLAKHGLIHGDFNEFNILIREDKIENKSTNTSTDTTDTPADTNEQQQQQQQQQQQDTTAPSITLTPILIDFPQMVSMDHQNAEMYFDRDVECVKRFFSRRFHFVSTEPGPFFKDAKKTVGRDGARRLDAVVEASGFTKKMAKDLEAAIREQQANPKNDTGDSDEEEDESENEDEDEDENGGEGLQVIGDQIVSTEEGLEKLAINDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0U3</accession>
    <name>Q2H0U3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_04603</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223817.1">
        <property type="nucleotide sequence ID" value="XM_001223816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0U3"/>
    <dbReference type="STRING" id="306901.Q2H0U3"/>
    <dbReference type="GeneID" id="4392107"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04603"/>
    <dbReference type="eggNOG" id="KOG2665">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024775_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H0U3"/>
    <dbReference type="OMA" id="GVHFTRM"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF4">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="9">
        <location>
            <begin position="47"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ87984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="429" mass="45804" checksum="5901DE0E7C4ECDC9" modified="2006-03-21" version="1">MRPGLGRRLPLLLRGQHATNNTITAATRPFSQTTPNLSQLGADFTHAVIGGGVVGLAIARALAQRSSSSTHNGGSSSTLLLERHTSVGTETSSRNSEVIHAGLYYGAGTLKTTLCLQGKALLYNLCAAHDIPHRRTGKWIVAQTDAQRAALQRLHDFCTRELHVPVRWVGRDEAARREPAVRAESGVLESPTTGIVDSHALMMCLLGQFEEAGGTLALGSEVEEVVPLGGDGSGGWELTVRDGATGEVSTVTAETIVNSAGLGAVAVNNMIVPPKQRREMFYAKGNYFSYGASSPSVKTLVYPAPEPGQAGLGTHLTLDLGGRIKFGPDVEWVDSPDDLAVTESRRAQTVAEVKKYLPGLDEMQLQPDYAGIRPKLGKQGAVAQGKGFVDFVIQKEEGYQGWINLLNIESPGLTSCLAIAERVRKLLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H199</accession>
    <name>Q2H199_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_04447</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223661.1">
        <property type="nucleotide sequence ID" value="XM_001223660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H199"/>
    <dbReference type="FunCoup" id="Q2H199">
        <property type="interactions" value="743"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H199"/>
    <dbReference type="GeneID" id="4391957"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04447"/>
    <dbReference type="eggNOG" id="KOG1110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042860_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H199"/>
    <dbReference type="OMA" id="ANEWETQ"/>
    <dbReference type="OrthoDB" id="547796at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF72">
        <property type="entry name" value="NEUDESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="8">
        <location>
            <begin position="63"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ87828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="174" mass="19141" checksum="87FDB958278F2D25" modified="2006-03-21" version="1">MDYVQQRMAQAAASTDASSSTLLTPLNGLLLSILLYTAYTFLLRPTPPPQLPKEEPAVVFRTFTPPTLRPYNGENGMPVYLAVRGRVFDVSRGRNFYGPGGPYENFAGRDASRGLACGSFDEDMLTKDLEGPLDKLEGLGPSEMEALQGWEERFEEKYLVVGKLVAVGEEGKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1C4</accession>
    <name>Q2H1C4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_04422</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223636.1">
        <property type="nucleotide sequence ID" value="XM_001223635.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4392514"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04422"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001613_8_1_1"/>
    <dbReference type="InParanoid" id="Q2H1C4"/>
    <dbReference type="OMA" id="PENCWIS"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF6">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="5">
        <location>
            <begin position="287"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="4">
        <location>
            <begin position="554"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="1176"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="480"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ87803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1671" mass="191516" checksum="538E7ED54F946608" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H251</accession>
    <name>Q2H251_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glycosyltransferase family 71 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_04145</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223359.1">
        <property type="nucleotide sequence ID" value="XM_001223358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H251"/>
    <dbReference type="FunCoup" id="Q2H251">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H251"/>
    <dbReference type="GeneID" id="4392146"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04145"/>
    <dbReference type="eggNOG" id="ENOG502S4MX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040188_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H251"/>
    <dbReference type="OMA" id="PIEIHYW"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ87526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="53515" checksum="176B4E12F9B33401" modified="2006-03-21" version="1">MAIPRRILLVAVGLVCFIGFFTFHLHTRDTLSNARPEYLSPNRIPTHSQKTGQLDPEAHKLPWADSFSAHFKALTDVKNITMAEAKAGCHWPADEDVNFQYNADVGWVVTDRPDEEINARRKAWQEWCSGAWPGYSPRIPLEIHYWDNEMTEATLKDLAAIYQPMSFNDLSKPDNIIQVKKDGEYLNFQLKTAALINSKFAEPLLLDSDNIPILDPASLYESRVYQEYRTVFWPDIARSWPQNPAWAITNTPCRMDEYEQESGQMMVDKRRYWYHLQLAAWLNNDQGRYYNEFLLGDKDMFRFAWHALKTAYGRPKKWLTSVGTLNDGSYYCGHSFAQHHPDDGRVAFLHGGLVKWTAPEVMRWNREEMGGYFRHYKRAPTDEDPAQIVHVGIKFDEAKYMPDHTEPYKVAMCTDMRDLEAGNLDDILPGWEKEYEELGGYWMLEQETKSVAESEKAGAHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H254</accession>
    <name>Q2H254_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Aprataxin-like protein</fullName>
            <ecNumber evidence="4">3.6.1.71</ecNumber>
            <ecNumber evidence="3">3.6.1.72</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Hit family protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CHGG_04142</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 3'-end 2'-deoxyribonucleotide-3'-diphospho-5'-guanosine-DNA + H2O = a 3'-end 2'-deoxyribonucleotide 3'-phosphate-DNA + GMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:52140"/>
            <dbReference type="Rhea" id="RHEA-COMP:13186"/>
            <dbReference type="Rhea" id="RHEA-COMP:13187"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:136419"/>
            <dbReference type="ChEBI" id="CHEBI:136420"/>
            <dbReference type="EC" id="3.6.1.72"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5'-end adenosine-5'-diphospho-5'-2'-deoxyribonucleoside-DNA + H2O = a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:52128"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:13181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:136413"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 5'-end adenosine-5'-diphospho-5'-ribonucleoside-2'-deoxyribonucleotide-DNA + H2O = a 5'-end 5'-phospho-ribonucleoside-2'-deoxyribonucleotide-DNA + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:52132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13182"/>
            <dbReference type="Rhea" id="RHEA-COMP:13183"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136414"/>
            <dbReference type="ChEBI" id="CHEBI:136415"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.71"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.1.71" evidence="4"/>
    <dbReference type="EC" id="3.6.1.72" evidence="3"/>
    <dbReference type="EMBL" id="CH408032">
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        <property type="nucleotide sequence ID" value="XM_001223355.1"/>
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    <dbReference type="STRING" id="306901.Q2H254"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:DNA 5'-adenosine monophosphate hydrolase activity"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF4">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT" evidence="21">
        <location>
            <begin position="96"/>
            <end position="222"/>
        </location>
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        <location>
            <begin position="238"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012496"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024601"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF16278"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ87523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="299" mass="33188" checksum="98113B70CD6DCF95" modified="2006-03-21" version="1">MTEPADDEAKIPRPESASPGSRPPTATEAEKKTTQAVTSPANAPAKRNAFTELMAPKPEAPISQAPQSMASKASQIVRGVWRGALIEYIEHPERFPDKVLRVTANTVLIKDAFPKATIHLLLLPRSPAHYLLHPHSAFADPAFLTMMREEAAVGAQLAAAELARKLGPFSASNRTRDEAMGKGGVPFDELPAGRDYAAEIRVGIHAHPSMAHLHVHIISRDMHSERARHKKHYNSFVTPFFVPLADYPLAEDDVRRETGFQNGNLKRDLVCWRCGKNFGARFAELKKHLEEEFEAWRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2D4</accession>
    <name>Q2H2D4_CHAGB</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="809"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="879" mass="97780" checksum="2BC491F90AF970B3" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2F1</accession>
    <name>Q2H2F1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_04045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87426.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="4392783"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04045"/>
    <dbReference type="eggNOG" id="ENOG502T71Q">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_934016_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2F1"/>
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    <dbReference type="OrthoDB" id="4572647at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ87426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="341" mass="37384" checksum="621AFE41E1A0EC8C" modified="2006-03-21" version="1">MTNNLNRQPSDSDALDQSDDKDSILDTYLVGIGLAQWVPEIHSAIAQGAQDVLSIMTQPRSVDEIREASRKMRHSPASTIQVTGIMWYLTYLSIERGQTFVTGAYLCRDPEGRLAAYFNGIGTPRISSHLKRHTSPGCTAGIDLRIPAGKSNIAERPPPLPHGHCHILSIAIVNDKRRGKCLYLKPERYGVHGIRNLAHHAIMYSKSLKRKHTFGGNEVPGMRKERIPDDFVVAFAEAAASLEGGSDAIAEVGRRGKGEGIGGMYEFLTRTLGDASVVLPEGSEKRMRHLLGRLESEYDFVDLRFGNEVVIDLPVEINRTLPEAPGVVGPSPLLRWASSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2R7</accession>
    <name>Q2H2R7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_03929</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223143.1">
        <property type="nucleotide sequence ID" value="XM_001223142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2R7"/>
    <dbReference type="STRING" id="306901.Q2H2R7"/>
    <dbReference type="GeneID" id="4392867"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03929"/>
    <dbReference type="eggNOG" id="KOG1102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005062_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H2R7"/>
    <dbReference type="OMA" id="PNVEMFR"/>
    <dbReference type="OrthoDB" id="159449at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000003">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000027">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="57"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="361"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="418"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="614"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="683"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="783"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="467"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="725"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="445"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="696"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="785"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="809"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ87310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="819" mass="89329" checksum="4B4943CA95A8A399" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2U1</accession>
    <name>Q2H2U1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_03905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223119.1">
        <property type="nucleotide sequence ID" value="XM_001223118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2U1"/>
    <dbReference type="GeneID" id="4392396"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03905"/>
    <dbReference type="HOGENOM" id="CLU_1651957_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2U1"/>
    <dbReference type="OrthoDB" id="10345236at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ87286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="160" mass="17269" checksum="7D4CC047CDA8336B" modified="2006-03-21" version="1">MTKAKNGYFIPFSDGDGILISAPTPWCRCRLLVSGGPRRLTNCQARGAETAARMGLVRNGRNFYPPRSFPFDGFDDEKLRVAAPGVRPYQQHVCLRKSFHVNAINLPIPDILGFVGGSVWGKGTRVVTQDDAGGDSGTSDGAGDIFTKGPLAINCNIRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3A5</accession>
    <name>Q2H3A5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cip1-like core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222955.1">
        <property type="nucleotide sequence ID" value="XM_001222954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3A5"/>
    <dbReference type="GeneID" id="4392759"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03741"/>
    <dbReference type="eggNOG" id="ENOG502SH79">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071363_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3A5"/>
    <dbReference type="OMA" id="CFEYHIG"/>
    <dbReference type="OrthoDB" id="5313668at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048955">
        <property type="entry name" value="Cip1-like_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21340">
        <property type="entry name" value="Polysacc_lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209241" description="Cip1-like core domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Cip1-like core" evidence="2">
        <location>
            <begin position="23"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="236" mass="25215" checksum="97DC18FA219ED49F" modified="2006-03-21" version="1">MLRQTALLALALVPATFAQVAEDFEGGWDETAWPTYAPDCNQGGKVALDSSTAHSGSNSIRVDGAGGFCGHIFFGTKSIPSGDLYVRAWVKASKALTDSHVTFITMPDPAQGTNKHLRIGGQSKILMYNRESDDATLPDLSPQGIAASAALPTGEWQCFEYHVGTDGSIETWLNGEAVEGLTSVPGDGNPNAGQWQRSSIKPTPEAVYFGWESYGGDTNTFWYDDIAIDSARVGCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3I9</accession>
    <name>Q2H3I9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear distribution protein RO10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_06776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222871.1">
        <property type="nucleotide sequence ID" value="XM_001222870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3I9"/>
    <dbReference type="GeneID" id="4391493"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06776"/>
    <dbReference type="eggNOG" id="ENOG502S5XV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091042_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3I9"/>
    <dbReference type="OMA" id="WYEVGLV"/>
    <dbReference type="OrthoDB" id="5403729at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ90157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="21610" checksum="D7A46A220A1B2DDA" modified="2006-03-21" version="1">MENNLDQTTLDTISLLEARLRRIEHILYGPTTAPTEPPQESAITSLAELERRFNQLLHRFHKSHPTLFQPPTATDALPPTQLPPDAVRATVLAYASAFPTVASSLTAATADSPIPDARQSAALAALGPRMRGAAALQHAQAREMSELRARSEVAVRAWYEGGVLRYGMVLADVEGRLERVDRGVRRVAKGRVEEEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H496</accession>
    <name>Q2H496_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription elongation factor Eaf N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_06519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222614.1">
        <property type="nucleotide sequence ID" value="XM_001222613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H496"/>
    <dbReference type="STRING" id="306901.Q2H496"/>
    <dbReference type="GeneID" id="4391115"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06519"/>
    <dbReference type="eggNOG" id="ENOG502SEGQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041956_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H496"/>
    <dbReference type="OMA" id="VDSTFHM"/>
    <dbReference type="OrthoDB" id="125903at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019194">
        <property type="entry name" value="Tscrpt_elong_fac_Eaf_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09816">
        <property type="entry name" value="EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription elongation factor Eaf N-terminal" evidence="2">
        <location>
            <begin position="15"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="341" mass="37335" checksum="39CB2B2571DF333C" modified="2006-03-21" version="1">MAAPGVLDPTKAGQYPVILSDALLGKPSKETYTGIRYNHRPTLSSDTAPNTARLKKSAKDDSYNIGFDDQGDKYQYNGVRTTDDGNYVLIFDPARKAFVLHRVDSTFHMNITRMPTDNNAESLRQQFPQLEVKTADSTRKPRGKVAEKASNSRPNTAKAAPTKSKGGRNLAAGDTPKSKASGQPEKNKTLELTLPDLSAAAANPKKQPSASQPGQEKKPKRPALSPVESEEDDDDDDGGLTVEYPEGNPAAFRAPSQYIPTFPSVTRRFSEFANERESDDDDFDTTMAGGYDAGLPEEEGYAGDEYEEEDEEEPSRRPASPARPFPVGDARRRRTGPVHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4I0</accession>
    <name>Q2H4I0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_06435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222530.1">
        <property type="nucleotide sequence ID" value="XM_001222529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4I0"/>
    <dbReference type="FunCoup" id="Q2H4I0">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H4I0"/>
    <dbReference type="GeneID" id="4390901"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06435"/>
    <dbReference type="eggNOG" id="KOG1337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041939_3_0_1"/>
    <dbReference type="InParanoid" id="Q2H4I0"/>
    <dbReference type="OMA" id="VWDEVCI"/>
    <dbReference type="OrthoDB" id="441812at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31880" checksum="51404F1202AB5659" modified="2006-03-21" version="1">MPSRDSIISSLPLAWDPRLHAYLPKPALALLRKQQAKFTRDWTAIQQTPFASTDTPNPTITRQDYLYTWLLVNTRTFYHETPLTRRAPREDRMVLQPVADLFNHSGTGCAVHLHTHPIHHHGGPRLCHRRRGGHLLRETPQRLFVGQQQRGGGNCWDEVCLDEAVLPALGAGHRALLEERGFLGNYVLDAGTVCYRTQVALRVLCVTPGQWERLVSEGEDGGEGLQEEVDRLLLGLLRKWRGVVAGKIEEVEGLDVGQACQRQILCARWRQIASLVDQTIEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4S9</accession>
    <name>Q2H4S9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222431.1">
        <property type="nucleotide sequence ID" value="XM_001222430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4S9"/>
    <dbReference type="GeneID" id="4390923"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06336"/>
    <dbReference type="eggNOG" id="ENOG502RJ52">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118227_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4S9"/>
    <dbReference type="OrthoDB" id="4568923at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="18648" checksum="7A191A6AAA20EE69" modified="2006-03-21" version="1">MTTTQPPSEPTRRTTALRNLQTLYTNLTLLHTIASPSIILHPADRDLTTPPRPPLVGIAAAQQHEEDLVAAAARRGGLVMEVGVGSGGMVVDEGGVFGCVMGVLRGGSSSSGASSCEGKGGDGQEGRGGGEGVEREKQKEGIAMPFCGVWRFDEMGRAVEHWENAADPAALGRWLRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4U0</accession>
    <name>Q2H4U0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222420.1">
        <property type="nucleotide sequence ID" value="XM_001222419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4U0"/>
    <dbReference type="GeneID" id="4390593"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06325"/>
    <dbReference type="HOGENOM" id="CLU_1496020_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4U0"/>
    <dbReference type="OrthoDB" id="4583895at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="180" mass="19523" checksum="4E1F91CC341B0BEB" modified="2006-03-21" version="1">MASSHHNAQLAEEPIEPDDDIPATVDDHQYYGTQRPPYWYRICPGGFLIPPPLPPSSEQHHGVPPAQGPPVDGVLVHAQPVSDQHHQAPRDAQPRGISQEPTSWESRTGATNTHQPPEPTPASQGSTTALRPNSEPQSQDRQRCDLASHEAQVNSQGVSQQWPPPFSAAPISADRNMPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H512</accession>
    <name>Q2H512_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222348.1">
        <property type="nucleotide sequence ID" value="XM_001222347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H512"/>
    <dbReference type="GeneID" id="4390302"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06253"/>
    <dbReference type="eggNOG" id="ENOG502SCAA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022029_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H512"/>
    <dbReference type="OMA" id="YMEVGWI"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035426">
        <property type="entry name" value="Gemin2/Brr1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04938">
        <property type="entry name" value="SIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="428" mass="47131" checksum="934A03EA47ED71BA" modified="2006-03-21" version="1">MGPKRNHNAVTAGDDNELSYPSSNKRRREQQPSKPKQVEGKPDPTYGQRTAFPGLDDDGSAQFSDDDLEFEQNAEALAYLRAVRAPTPSTAASTPTASATHEATTTMAQRRPPQSLFRFAHRALPAPPRPPPPNPVRIGHCQPCRGDHGTEVGSFGANSWTFRVWTKRIRHTDPLPAQIAALKRQSVLKLLRVILGGKFIRRGYELRPRTSRWIWALLARLPDQGEMDYVEVGWVRELGKRAVLMMVSIAHMDALREEVEGDLEGNIDGDDEEEFVEEMVLDEDGEEHAISTSTKPQPPAAVTTDADNGEGQDGEMDMDIDEGEVTDDDAPSTAGNKDIAADIAAAKARLLARLEENTSTQQEKVLVAAHADTPEDRPNGSSDEETATMDEAEARANMRATLNMVLTVAGEFYGQRDLLEFRDPFPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5M7</accession>
    <name>Q2H5M7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_06038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222133.1">
        <property type="nucleotide sequence ID" value="XM_001222132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5M7"/>
    <dbReference type="GeneID" id="4389952"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06038"/>
    <dbReference type="HOGENOM" id="CLU_1320761_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5M7"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="208" mass="23028" checksum="6E0A8F320518ADFF" modified="2006-03-21" version="1">MTDFNNRRKSEQCAASESHHDEADDTHYQDSTDSLDLLLLPDGDDDDLNPNPDDHDAREHLRPSTTTKIITMAVVIVAVLLLGFVVVEGARALANIAATVVSCIHICCERGRAMIEAAIDRAHRHAVESEARMDALLENHRAPIDDFSARMDEFRARMHDYHARMDNSWAGRNRNHDGDPLGGFGAGLYDTEADLEDIGALLDDLLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5R7</accession>
    <name>Q2H5R7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HCNGP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222093.1">
        <property type="nucleotide sequence ID" value="XM_001222092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5R7"/>
    <dbReference type="STRING" id="306901.Q2H5R7"/>
    <dbReference type="GeneID" id="4390954"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05998"/>
    <dbReference type="eggNOG" id="KOG2959">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064352_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H5R7"/>
    <dbReference type="OMA" id="TLSKEVW"/>
    <dbReference type="OrthoDB" id="1714508at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012479">
        <property type="entry name" value="SAP30BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464:SF0">
        <property type="entry name" value="SAP30-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR PROTEIN HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07818">
        <property type="entry name" value="HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="25484" checksum="BD435B547EF73C7B" modified="2006-03-21" version="1">MTGLVQYDSSDEDEGVQTPVDVVRICGHATITTRTTLANRLTEPEPTATSSSTPTHPPPPAPAPVPTPALGPVLGPTLGPSRPPPPKTTTNASDQKPQAEQEEAAEEIDLAFLSAPDNTNPSQRSPSPYTRTRTLLHNLTLPAVPNMDIPASPPGSPPPGLDALTAKFDTFLRLKRTRGVHFNERLARSAGMANPAVVERLLGFVGVGTEFGGEGGEDGDVEMGGGGGGGEGEGLVGGAWSSTRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5T2</accession>
    <name>Q2H5T2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222078.1">
        <property type="nucleotide sequence ID" value="XM_001222077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5T2"/>
    <dbReference type="GeneID" id="4391402"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05983"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_1_1"/>
    <dbReference type="InParanoid" id="Q2H5T2"/>
    <dbReference type="OrthoDB" id="4589250at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="416" mass="46156" checksum="DB06C2F2431EB27F" modified="2006-03-21" version="1">MRSPPREARLRMAVEAIGKNKNLSIRAAARQYNVPEATIRHRCTGRSARRDLPANSRKLTDLEERTIVQYILELDARAFPPRLRGVEDMANHLLRERDAPPVGKLWALNFRQAPATASVRVVRVDTITRGPSAKIQRSLASGLRLYRTLRPKYGIVDDDVYNFDETGLMMGIIFAGQAYGRLIDELMRAHINHITKLEFLCAFREAFFASMTEKNIQGGFSGAGIVPFDPERVLSKLDVKLHTPTHPDSRPGTAQPWASKTPYNAQETRSQSDFIKTRISSYQNSSPASVLVAVDQLTKGATAVMHQVALLQSEVSSLRKANEPLSKRRKAKRTRIQLGGPLTVQDAQDPLDQRDVGKGALQETQPDSSGAGGARAKVRRCNSCCKFMCNVALPIRLLLDMKPVFGAVEMNGNEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6F7</accession>
    <name>Q2H6F7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_05758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221853.1">
        <property type="nucleotide sequence ID" value="XM_001221852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6F7"/>
    <dbReference type="GeneID" id="4391059"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05758"/>
    <dbReference type="HOGENOM" id="CLU_2096597_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6F7"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="116" mass="12558" checksum="F448E7633DE1D8E8" modified="2006-03-21" version="1">MGVTTAAATPRSLLPVVQKFFRPVSASSSFRIAGLNRTSHIYQPLLAKKAAPHGRITAPAASRSGSLIDSEYMLLILIFPKAEDSNHRPVEVNPMRHASGTQLCHFVPARTYVGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H732</accession>
    <name>Q2H732_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_05533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221628.1">
        <property type="nucleotide sequence ID" value="XM_001221627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H732"/>
    <dbReference type="STRING" id="306901.Q2H732"/>
    <dbReference type="GeneID" id="4391332"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05533"/>
    <dbReference type="eggNOG" id="ENOG502S130">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_25_0_1"/>
    <dbReference type="InParanoid" id="Q2H732"/>
    <dbReference type="OrthoDB" id="4842715at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ88914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="37612" checksum="D5D07FF6BF90ED21" modified="2006-03-21" version="1">MKTQSYALSRIAAKTWGLGLAKAREVYTKCIRSALAYGASSFHIPTDVEGEPVKKGITGALGKVQNKSLRIVAGAFKATPIRNLETETWVPPLDLYFNKRLADFETRLQRTDLDDGQGGKRTAGGIILTACRKIQQRLHPRSGNRGRPRTVGLQEPTAVEKAASTIARWTGGAADTDSVVEDAWRARWLKERDGRAVIRPADDLDHQRETLFRDETLRRHDGLSKAKSSLLVQIRTGAVGLRDFLFTRGVPEVLTPACQCGEGRETAEHLVVWCLAPPLTRRWERTDIRTRRDFYSVLHGIDPTSARLAGRVLEWLMDSGRLMMFSLARRLELEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H735</accession>
    <name>Q2H735_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221625.1">
        <property type="nucleotide sequence ID" value="XM_001221624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H735"/>
    <dbReference type="STRING" id="306901.Q2H735"/>
    <dbReference type="GeneID" id="4391329"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05530"/>
    <dbReference type="eggNOG" id="KOG1119">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069054_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H735"/>
    <dbReference type="OMA" id="WRATHAI"/>
    <dbReference type="OrthoDB" id="1938621at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="9"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="310" mass="33452" checksum="06EA1B9B1012D580" modified="2006-03-21" version="1">MPKFYLPQKPLGTPLKGRSCHPNSPVTEAPKNPAVTDTTNFGPHMPRLRCANAPSTATLFIQLSMRRQAVSCGLPILDVLLPVSSRAARAPFIRAHHVASTGRITGTHRHEPSSTAVCIPGRGGTPRSTLPKARATPLRLLSRPFSTSSSWRATHAIFNPQIDDDGKDMVLEITQRAAKRLSEIMAKDSNPNLALRIQVESGGCHGFQYLMKLVTLPPALPTQDSLRLGTDDHSTVIHEDDTIFTYASDGSSSPGDLTAPKIILDLPSLELLKGSKVDFTMELIGSQFKIVDNPLATSSCGCGTSFDIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H785</accession>
    <name>Q2H785_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221575.1">
        <property type="nucleotide sequence ID" value="XM_001221574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H785"/>
    <dbReference type="GeneID" id="4391020"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05480"/>
    <dbReference type="HOGENOM" id="CLU_2291362_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H785"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="101" mass="10638" checksum="AB68C966CB8D088C" modified="2006-03-21" version="1">MGQPTPSRDRSINNSRTDSQAREVRQGRKDGGSPNELGGVVWARSGTRQDTRAQVTSVGYSACRSSGNHNFADDVQPPAACKQGGGEHQTSPGSSAGQLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7Z2</accession>
    <name>Q2H7Z2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230178.1">
        <property type="nucleotide sequence ID" value="XM_001230177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7Z2"/>
    <dbReference type="GeneID" id="4388433"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03662"/>
    <dbReference type="eggNOG" id="ENOG502T8H9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022148_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H7Z2"/>
    <dbReference type="OMA" id="RANFYAM"/>
    <dbReference type="OrthoDB" id="2831684at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209339" description="Beta-glucuronidase C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="2">
        <location>
            <begin position="402"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="515" mass="55091" checksum="53B5ECC61E1BB436" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7Z8</accession>
    <name>Q2H7Z8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230172.1">
        <property type="nucleotide sequence ID" value="XM_001230171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7Z8"/>
    <dbReference type="STRING" id="306901.Q2H7Z8"/>
    <dbReference type="GeneID" id="4388507"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03656"/>
    <dbReference type="eggNOG" id="KOG3348">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_487437_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7Z8"/>
    <dbReference type="OrthoDB" id="60858at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919">
        <property type="entry name" value="PROTEIN CBG05606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="559" mass="60491" checksum="C9EBC441068C853C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8D1</accession>
    <name>Q2H8D1_CHAGB</name>
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        <recommendedName>
            <fullName evidence="8">NUDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_03523</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nudE family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230039.1">
        <property type="nucleotide sequence ID" value="XM_001230038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8D1"/>
    <dbReference type="STRING" id="306901.Q2H8D1"/>
    <dbReference type="GeneID" id="4388562"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03523"/>
    <dbReference type="eggNOG" id="KOG1853">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034391_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8D1"/>
    <dbReference type="OMA" id="NMAIERS"/>
    <dbReference type="OrthoDB" id="5877028at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033494">
        <property type="entry name" value="NUDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006964">
        <property type="entry name" value="NUDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921:SF1">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04880">
        <property type="entry name" value="NUDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUDE" evidence="8">
        <location>
            <begin position="131"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="190"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="345"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="288"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ91588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="632" mass="67884" checksum="21053FF5C4542867" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8U4</accession>
    <name>Q2H8U4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_03360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229876.1">
        <property type="nucleotide sequence ID" value="XM_001229875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8U4"/>
    <dbReference type="STRING" id="306901.Q2H8U4"/>
    <dbReference type="GeneID" id="4388540"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03360"/>
    <dbReference type="eggNOG" id="KOG1287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013661_4_1_1"/>
    <dbReference type="InParanoid" id="Q2H8U4"/>
    <dbReference type="OMA" id="FVYLEFG"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF382">
        <property type="entry name" value="LOW-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ91425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="52435" checksum="63DB9BE8416B15A2" modified="2006-03-21" version="1">MQEPEIFEQPVASKDPEAHGAGDEHAMYGGAYGGTIYSNGVSPVAARDDESDDYRDFVFPEGWSCPSPSPLRVWVIDTALTLQFVLFAISTGNSISFSSYLLHAATKSSQEGTWMNQGIAIAAITVVCLIHAFAPRWGIWLSNGFGAFKLVMLSLLVCTGFAALAGRTATPRPDNFSSFHGAGSSRAPDDNPAGAAGGYSIALLQVLYSYSGWENANYVLTEFAAMSKIEIANAKTVVAAKFFENVWGESSFVTRVVPLFIGLSALGNAFAQSFAMPRVKQELSKEGVLPFSRFWASDWPFNAPSGAIFLHWIFTVIFILGCRTPDVYSFVTNVFIYSGNWIKLFLALGLVYLNFAPSERWAEQRTTFRSSPLLTIFWILSLLFVQVAPFIDNDFLLFVPYYVFPTLGTSLLVIGTGYWLVWAKVLPAFGYHIQHEIVQMPDGSERVKYKRVKPKKRKKPGQWTRQRKRSVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8Y4</accession>
    <name>Q2H8Y4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">3-dehydrosphinganine reductase</fullName>
            <ecNumber evidence="14">1.1.1.102</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CHGG_03320</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>sphinganine + NADP(+) = 3-oxosphinganine + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.102"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:22642"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.102" evidence="14"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229836.1">
        <property type="nucleotide sequence ID" value="XM_001229835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8Y4"/>
    <dbReference type="STRING" id="306901.Q2H8Y4"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:sphingolipid biosynthetic process"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="KDSR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="3-ketodihydrosphingosine reductase tsc10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022190">
        <property type="entry name" value="DUF3716"/>
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        <property type="entry name" value="KDSR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12511">
        <property type="entry name" value="DUF3716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="348"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="520"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAQ91385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="797" mass="85930" checksum="A9C6C6C2770A3463" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H932</accession>
    <name>Q2H932_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_03272</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS18 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EAQ91337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229788.1">
        <property type="nucleotide sequence ID" value="XM_001229787.1"/>
    </dbReference>
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    <dbReference type="STRING" id="306901.Q2H932"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03272"/>
    <dbReference type="eggNOG" id="KOG2034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003488_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H932"/>
    <dbReference type="OMA" id="WIQREKW"/>
    <dbReference type="OrthoDB" id="1845386at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16462">
        <property type="entry name" value="RING-H2_Pep3p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007810">
        <property type="entry name" value="Pep3/Vps18_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058919">
        <property type="entry name" value="Pep3/Vps18_RING_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF26">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05131">
        <property type="entry name" value="Pep3_Vps18"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26148">
        <property type="entry name" value="VPS18_RING_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pep3/Vps18 beta-propeller" evidence="9">
        <location>
            <begin position="24"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Pep3/Vps18 beta-propeller" evidence="9">
        <location>
            <begin position="88"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="624"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="Pep3/Vps18 RING C-terminal" evidence="10">
        <location>
            <begin position="859"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="814"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF26148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ91337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="966" mass="106735" checksum="59AD1350E4BA7E4F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H966</accession>
    <name>Q2H966_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_03238</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229754.1">
        <property type="nucleotide sequence ID" value="XM_001229753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H966"/>
    <dbReference type="FunCoup" id="Q2H966">
        <property type="interactions" value="912"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H966"/>
    <dbReference type="GeneID" id="4388631"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03238"/>
    <dbReference type="eggNOG" id="KOG1570">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062853_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H966"/>
    <dbReference type="OMA" id="CTHNEAL"/>
    <dbReference type="OrthoDB" id="2449818at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000002">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000009">
        <property type="entry name" value="Ribosomal protein L10a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ91303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="178" mass="19577" checksum="5113758F75A3CFD5" modified="2006-03-21" version="1">MSKITVAGVRQNVAELLEYSNETKKRNFLETVELQIGLKNYDPQRDKRFSGTVKLPSVPRPNMAICILGDQHDIDRAKHGGVDAMSADDLKKLNKNKKLIKKLARKYDAFVASDTLIKQIPRLLGPGLSKAGKFPTPVSHADDLSAKITEVKSTVKFQLKKVLCMGVAVGNVGMTQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H989</accession>
    <name>Q2H989_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-aminobutyrate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GABA aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-amino-N-butyrate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_03215</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23352"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="2.6.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="3"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229731.1">
        <property type="nucleotide sequence ID" value="XM_001229730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H989"/>
    <dbReference type="FunCoup" id="Q2H989">
        <property type="interactions" value="242"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H989"/>
    <dbReference type="GeneID" id="4389689"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03215"/>
    <dbReference type="eggNOG" id="KOG1405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_12_0_1"/>
    <dbReference type="InParanoid" id="Q2H989"/>
    <dbReference type="OMA" id="GLMCAFD"/>
    <dbReference type="OrthoDB" id="10260828at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000029">
        <property type="entry name" value="4-aminobutyrate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004631">
        <property type="entry name" value="4NH2But_aminotransferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00699">
        <property type="entry name" value="GABAtrns_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF1">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ91280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="509" mass="56188" checksum="CDAC7594C7A1BA6F" modified="2006-03-21" version="1">MSACRTLRSSNALLRAVSSPPIARPVVGSLEARRRFTASTRAMSSFYPSWEPEGPSVKTDIPGPKSKAAIAELDDVFDTRSLNMLTDYTKSVGNYIADPDGNVLLDVYAQIASIPLGYNNPALRKAAQSDDMINGIINRPALGNFPPAEWARILKTGILKVAPKGLDQVFTAMAGSDANETAYKAAFMWRRQRERGGPNVEFTEEEMNSAMNNQSPGASQLSILSFKTGFHGRLFGSLSTTRSKPIHKLDIPAFDWPQATFPQLKYPLDQHAAENAAAERAALDEVERLLTTYHVPPCAVVVEPIQSEGGDNHATPAFFRGLREVTRKHGVLLIVDEVQTGVGATGRFWAHEHWDLPHPPDMVTFSKKAQTAGYYFGDPALRPNKPYRQFNTWMGDPARALLFRAIVDEVKKHDLVRHTERVGNYLFGKLEGLAAKYPGEFQNLRGKGMGTFIAFDNPRRDQFLAVAKKLGVNIGGSGQSAVRLRPMLIFEEKHADILVGVLEKIVTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9N5</accession>
    <name>Q2H9N5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome assembly protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Elongation factor-like 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_03069</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229585.1">
        <property type="nucleotide sequence ID" value="XM_001229584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9N5"/>
    <dbReference type="FunCoup" id="Q2H9N5">
        <property type="interactions" value="732"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H9N5"/>
    <dbReference type="GeneID" id="4388786"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03069"/>
    <dbReference type="eggNOG" id="KOG0467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_3_1_1"/>
    <dbReference type="InParanoid" id="Q2H9N5"/>
    <dbReference type="OMA" id="FARCDIQ"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000006">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000002">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000746">
        <property type="entry name" value="Ribosome assembly protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EFG_II"/>
    </dbReference>
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        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056752">
        <property type="entry name" value="EFL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25118">
        <property type="entry name" value="EFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="17"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="433"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="740"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="834"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="838"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ91134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1047" mass="115138" checksum="791BA26B38E3C000" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9Z4</accession>
    <name>Q2H9Z4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_02960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the THADA family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229476.1">
        <property type="nucleotide sequence ID" value="XM_001229475.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2H9Z4">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H9Z4"/>
    <dbReference type="GeneID" id="4389754"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02960"/>
    <dbReference type="eggNOG" id="KOG1810">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001011_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H9Z4"/>
    <dbReference type="OMA" id="LIMDPFD"/>
    <dbReference type="OrthoDB" id="73997at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056843">
        <property type="entry name" value="THADA-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056842">
        <property type="entry name" value="THADA-like_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019442">
        <property type="entry name" value="THADA/TRM732_DUF2428"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051954">
        <property type="entry name" value="tRNA_methyltransferase_THADA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387:SF0">
        <property type="entry name" value="DUF2428 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387">
        <property type="entry name" value="THADA/DEATH RECEPTOR INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10350">
        <property type="entry name" value="DUF2428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25150">
        <property type="entry name" value="TPR_Trm732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25151">
        <property type="entry name" value="TPR_Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26523">
        <property type="entry name" value="Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like TPR repeats region" evidence="4">
        <location>
            <begin position="165"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2428" evidence="3">
        <location>
            <begin position="590"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like C-terminal TPR repeats region" evidence="5">
        <location>
            <begin position="831"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ91025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1497" mass="164073" checksum="1B7D59276D9C7F26" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HA89</accession>
    <name>Q2HA89_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_02865</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229381.1">
        <property type="nucleotide sequence ID" value="XM_001229380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HA89"/>
    <dbReference type="FunCoup" id="Q2HA89">
        <property type="interactions" value="390"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HA89"/>
    <dbReference type="GeneID" id="4388877"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02865"/>
    <dbReference type="eggNOG" id="KOG1472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015741_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HA89"/>
    <dbReference type="OMA" id="IEYRVVN"/>
    <dbReference type="OrthoDB" id="1937912at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000004">
        <property type="entry name" value="Histone acetyltransferase KAT2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="77"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="318"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="16"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAQ90930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="414" mass="47434" checksum="1615F38A2B1722A4" modified="2006-03-21" version="1">MDNTFTWIPTGQERKTTFAKRLVPEPSNAAPDAKRFKNSHDDELPETKADVRSSTGPPQRVPFPDKPAVLEERNGEIEFQVVNNDGAKHSMIILTGLKCLFQKQLPKMPKDYIARLVYDRTHTSIAIVKKRLEVIGGITFRSFKARQFAEIVFCAVSSDQQVKGYGAHLMAHLKDYVKATSPVMHFLTYADNYATGYFQKQGFSKDITLDKSLWMGYIKDYEGGTLMQCSMVPRIRYLDTGRMLLKQKETVQAKIRALSKSHVVHQPPPEFAAGKPIDPLSIPAIRATGWSPDMDELARVPRHGPHFNELRRFLYQIQNHKQAWPFLNPVNRDEVPDYYKFIASPMDLSTMEGRLESDAYETPKDLVADLKLIFSNCRQYNDASTVYAKCAAKLEKYMWSLIKEIPEWFELLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HA96</accession>
    <name>Q2HA96_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor tau 55 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229374.1">
        <property type="nucleotide sequence ID" value="XM_001229373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HA96"/>
    <dbReference type="FunCoup" id="Q2HA96">
        <property type="interactions" value="118"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HA96"/>
    <dbReference type="GeneID" id="4389890"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02858"/>
    <dbReference type="eggNOG" id="ENOG502RYP8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042838_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HA96"/>
    <dbReference type="OMA" id="ICAHAAP"/>
    <dbReference type="OrthoDB" id="414418at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07040">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF51">
        <property type="entry name" value="TRANSCRIPTION FACTOR TAU 55 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="35749" checksum="88706FC347912995" modified="2006-03-21" version="1">MLEVIYVTRHGFRSNWLVDPSNGNYTTFIKSPTGGAADPALTAHGVDQANELAVRLLAVDPPIERVYSSLYYRCLQTVQPFVRQTQEEASKTARGKPALKIRGETGLGEWYGSADFEHPVPASLGKLDPLFPGLLDLDYGPTVTPSRMGEAIDELHGRVAATMEALIAQCDRDGVRAILLCSHAAVIIALGRVLTGQMPDSIDTDDFQCFTCGLSAYRRRRRQGLKTEGMDEPAGEPTAARDADHHGKGGTAMDWRGGRGVSGGWDCELNSDCAHLSLGEERGWRFSGDESFKDMATGQSMLDTTTRLGAASDGRTKELGKRAESSLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAP6</accession>
    <name>Q2HAP6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_02708</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229224.1">
        <property type="nucleotide sequence ID" value="XM_001229223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAP6"/>
    <dbReference type="GeneID" id="4389328"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02708"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_23_6_1"/>
    <dbReference type="InParanoid" id="Q2HAP6"/>
    <dbReference type="OMA" id="DAYTTIR"/>
    <dbReference type="OrthoDB" id="4842715at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="4">
        <location>
            <begin position="244"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ90773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="806" mass="90312" checksum="F28EC32063960D38" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBT2</accession>
    <name>Q2HBT2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228838.1">
        <property type="nucleotide sequence ID" value="XM_001228837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBT2"/>
    <dbReference type="STRING" id="306901.Q2HBT2"/>
    <dbReference type="GeneID" id="4388438"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02322"/>
    <dbReference type="HOGENOM" id="CLU_667311_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HBT2"/>
    <dbReference type="OrthoDB" id="5428490at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="412" mass="45173" checksum="98ABED092DA22EA8" modified="2006-03-21" version="1">MQTTIETSHLKRGTPKLTSLWKWAATLRALQQEEIELKGHPVSQHPNRETKGKGIDRTPCQNHVEPPPTEVPRSEAVHSNSIVTEAATTTKAIEPPTRKPPEPPSAQTTVSPTATTIPTIPVQVPVSKLERVRTLKFRSRLKLNAQEIALSTAELNKLRAFSAFVGTANQRTLFGRQLPPCHRYAVSIELDGSGAQTYIWIDGLTRAEDIRDFHAVISQRKYRKYYEPWKLCFKMVEVSYTSGEEVDLDLGHDELTLCETLLREVRSGETRISTIGGLLEIDGCLVALTTSFAPPRLPFGSEQDGEGDVTVSSIATTLNDVDFPEDISEALVFKGDKSTIHLVAPPTIGDGKARDSDANPASMLQPNLAARISPAHPSRHYITDFCRNPSLASVKVRAGASGPHSGTIPDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-09-13" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBW6</accession>
    <name>Q2HBW6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228804.1">
        <property type="nucleotide sequence ID" value="XM_001228803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBW6"/>
    <dbReference type="GeneID" id="4388591"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02288"/>
    <dbReference type="HOGENOM" id="CLU_2084587_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HBW6"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209114" description="Cyanovirin-N domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="12113" checksum="A4FADCE336D55BA5" modified="2006-03-21" version="1">MLSPMILAILLPSALAFATPRAAPVAVRQADDICQCEPLEGGALWPAQPSHDITTNICVKGSGSVSCVARHGSGQLCVESEDDISCACVAAAAAQWENDEGGVWYLCNGGNVTIARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HC39</accession>
    <name>Q2HC39_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_02215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228731.1">
        <property type="nucleotide sequence ID" value="XM_001228730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HC39"/>
    <dbReference type="STRING" id="306901.Q2HC39"/>
    <dbReference type="GeneID" id="4389192"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02215"/>
    <dbReference type="eggNOG" id="ENOG502STAJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_723978_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HC39"/>
    <dbReference type="OMA" id="PTAQFAN"/>
    <dbReference type="OrthoDB" id="3689214at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ90280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="318" mass="34913" checksum="1D3FEA1A706D1CFB" modified="2006-03-21" version="1">MAIWGRPTGHQATPPVRREEEAGDARRQYLWNTPDGEKPDFAETYTHGDEVVFSWNALNNSIYDLWLTSWKPGPDPVAVCLAINLAHDGNLKLVTSDPPTAQFANETRYVLRFKPTTGRGEFVASDPDLSSPGFLLVEPAFHQQDVPSTTAPSMPTISRVIPARETATTMADSGSEEPFSNVTPAAAAGLTIGLILMVALLVAGEVWYLMWRRKRRRGGGEDGTTPASSRWRMKRFGKGDRGVFVRVDKAEMVIDDSIWMSPELPGDSTWGERLVHELQGSRLGRGNSLGRPLTINSSVVELDVGREVVMQRGNVIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCU8</accession>
    <name>Q2HCU8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221177.1">
        <property type="nucleotide sequence ID" value="XM_001221176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCU8"/>
    <dbReference type="STRING" id="306901.Q2HCU8"/>
    <dbReference type="GeneID" id="4387747"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01956"/>
    <dbReference type="eggNOG" id="KOG2819">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032056_3_0_1"/>
    <dbReference type="InParanoid" id="Q2HCU8"/>
    <dbReference type="OMA" id="YRKNDQK"/>
    <dbReference type="OrthoDB" id="411211at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005373">
        <property type="entry name" value="PHAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039156">
        <property type="entry name" value="PHAF1/BROMI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465:SF2">
        <property type="entry name" value="PHAGOSOME ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465">
        <property type="entry name" value="UPF0183 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03676">
        <property type="entry name" value="PHAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="512" mass="56597" checksum="4E5664F3EBDDE8CA" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCW3</accession>
    <name>Q2HCW3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Letm1 RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_01941</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221162.1">
        <property type="nucleotide sequence ID" value="XM_001221161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCW3"/>
    <dbReference type="FunCoup" id="Q2HCW3">
        <property type="interactions" value="488"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HCW3"/>
    <dbReference type="GeneID" id="4386563"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01941"/>
    <dbReference type="eggNOG" id="KOG1043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008958_5_2_1"/>
    <dbReference type="InParanoid" id="Q2HCW3"/>
    <dbReference type="OMA" id="LQHYWDG"/>
    <dbReference type="OrthoDB" id="275278at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="10">
        <location>
            <begin position="249"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="57"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="481"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="527"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ93706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="555" mass="61151" checksum="19B39D41F8B07A26" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HD15</accession>
    <name>Q2HD15_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WIBG Mago-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221110.1">
        <property type="nucleotide sequence ID" value="XM_001221109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HD15"/>
    <dbReference type="STRING" id="306901.Q2HD15"/>
    <dbReference type="GeneID" id="4388135"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01889"/>
    <dbReference type="eggNOG" id="ENOG502SCAC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074603_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HD15"/>
    <dbReference type="OMA" id="IPGCADS"/>
    <dbReference type="OrthoDB" id="21625at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903259">
        <property type="term" value="P:exon-exon junction complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039333">
        <property type="entry name" value="PYM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015362">
        <property type="entry name" value="WIBG_mago-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036348">
        <property type="entry name" value="WIBG_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959:SF0">
        <property type="entry name" value="PARTNER OF Y14 AND MAGO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959">
        <property type="entry name" value="PYM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09282">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01273">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101931">
        <property type="entry name" value="Pym (Within the bgcn gene intron protein, WIBG), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WIBG Mago-binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="199" mass="21808" checksum="C7BA1FFC48E8E818" modified="2006-03-21" version="1">MAAQPTASGIVTDETSGERHIPESRRADGSTRKAIKIRPGYRPPEDVEVYKNRTAENFRNRGKGPIPGAEGLKDDKPAQSSSAAANKNAKRREARKKAKANDEGQGEAAPAEEVKEEVDPEAEKEKKVRNLKKKLRQAKELKEKKETGGELLPEQIAKVIKMNELIRELDALGFDAEGEPKAEEAGVEEAKPEKTEASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HD95</accession>
    <name>Q2HD95_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221030.1">
        <property type="nucleotide sequence ID" value="XM_001221029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HD95"/>
    <dbReference type="STRING" id="306901.Q2HD95"/>
    <dbReference type="GeneID" id="4388291"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01809"/>
    <dbReference type="eggNOG" id="KOG1206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040078_3_0_1"/>
    <dbReference type="InParanoid" id="Q2HD95"/>
    <dbReference type="OMA" id="FKHTDQE"/>
    <dbReference type="OrthoDB" id="60204at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044594">
        <property type="term" value="F:17-beta-hydroxysteroid dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078:SF57">
        <property type="entry name" value="DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078">
        <property type="entry name" value="PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peroxisomal multifunctional enzyme type 2-like N-terminal" evidence="2">
        <location>
            <begin position="17"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="MaoC-like" evidence="1">
        <location>
            <begin position="173"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="309" mass="33658" checksum="99BAF1BEFC7532C0" modified="2006-03-21" version="1">MSGPGVGFEYPPQEVSWTKRDALLFANTIGATADELHFLYELDPNFSVFPTYPIILTFKGTTQDVIDFYSAQKAVPIPGVPAFDPTRVVDGQRLLQSFQPLPASSAGKRFEIRTKVLGVYDKGRPGTVVDTQTDLVDAATATVYTRVISSSFYVAQGNWGGPKGPATVSFPAPKDRAPDVVFEKQTTPETALLYRLNGDYNPLHAHPEPGKKMGFGGVIIHGLYSWNWAAHGLLQHLGGSDPANMKEYQARFASPVRPGDKLVASAWKTGEKKGEWEEVRFEVKVEGGKVCLSNGRALMKCVAPAKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDA0</accession>
    <name>Q2HDA0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2005-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Giovannoni S.J."/>
                <person name="Cho J.-C."/>
                <person name="Ferriera S."/>
                <person name="Johnson J."/>
                <person name="Kravitz S."/>
                <person name="Halpern A."/>
                <person name="Remington K."/>
                <person name="Beeson K."/>
                <person name="Tran B."/>
                <person name="Rogers Y.-H."/>
                <person name="Friedman R."/>
                <person name="Venter J.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 148.51</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2006-02" db="EMBL/GenBank/DDBJ databases">
            <title>Annotation of the Chaetomium globosum CBS 148.51 Genome.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Birren B."/>
                <person name="Lander E."/>
                <person name="Galagan J."/>
                <person name="Devon K."/>
                <person name="Nusbaum C."/>
                <person name="Ma L.-J."/>
                <person name="Jaffe D."/>
                <person name="Butler J."/>
                <person name="Alvarez P."/>
                <person name="Gnerre S."/>
                <person name="Grabherr M."/>
                <person name="Kleber M."/>
                <person name="Mauceli E."/>
                <person name="Brockman W."/>
                <person name="Rounsley S."/>
                <person name="Young S."/>
                <person name="LaButti K."/>
                <person name="Pushparaj V."/>
                <person name="DeCaprio D."/>
                <person name="Crawford M."/>
                <person name="Koehrsen M."/>
                <person name="Engels R."/>
                <person name="Montgomery P."/>
                <person name="Pearson M."/>
                <person name="Howarth C."/>
                <person name="Kodira C."/>
                <person name="Yandava C."/>
                <person name="Zeng Q."/>
                <person name="Alvarado L."/>
                <person name="Oleary S."/>
                <person name="Untereiner W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 148.51</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221025.1">
        <property type="nucleotide sequence ID" value="XM_001221024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDA0"/>
    <dbReference type="GeneID" id="4388299"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01804"/>
    <dbReference type="HOGENOM" id="CLU_1796247_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HDA0"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="144" mass="16149" checksum="961E3346FF2617B1" modified="2006-03-21" version="1">MSSNSTQGYPGGIYIRSAEKREHVGRKEHNVKGEGKWSEYLARAFRNWPAKALSGRRNDARALPGTEGDYEPHLSLAIDHLMAYFGQELKSSLHGFIELQEQIDEGEGGSGPSRPDSRHQGITKCDNGNRSPRHTRSFSVTPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDK5</accession>
    <name>Q2HDK5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_01699</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220920.1">
        <property type="nucleotide sequence ID" value="XM_001220919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDK5"/>
    <dbReference type="STRING" id="306901.Q2HDK5"/>
    <dbReference type="GeneID" id="4387329"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01699"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HDK5"/>
    <dbReference type="OMA" id="ARETGFF"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050295">
        <property type="entry name" value="Plant_2OG-oxidoreductases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47991">
        <property type="entry name" value="OXOGLUTARATE/IRON-DEPENDENT DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="4">
        <location>
            <begin position="65"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="3">
        <location>
            <begin position="192"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ93464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="38569" checksum="5EB8A3C340EB7D76" modified="2006-03-21" version="1">MSFTSIPILDLALARDPATKPGFLSELRHALMEVGFLYLKNMRSMVNTSPLTLLPLKAEYLPRLKIEMKNAPSFLGYSRLSAEVTAGAIDNREQIDLSTEHPVPGPDAPRYYNLLAPNQWPSPEVLSNFRPIFTEYMKRMGAISIYFTSLIAEAIELPSGAFNKYFDADQQHKLKIVKYPDVGELGAEGSPHRGLQVQNMRGAWIDCPPIAGTLVVAIGQGLEALTGGVCASTTHRVLSPAAGAGARYSIPFFQGVSGDARFADLETVGVGAVVPAHVRAQREAVLRANGGRLDEVEFTFRGGGVAETLGEATLRNRVKSHPDVGERWYPDILESIREQQRKEAAAAAAATPAVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDL0</accession>
    <name>Q2HDL0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">L-arabinitol 4-dehydrogenase</fullName>
            <ecNumber evidence="10">1.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_01694</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-arabinitol + NAD(+) = L-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16381"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17399"/>
            <dbReference type="ChEBI" id="CHEBI:18403"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.12" evidence="10"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220915.1">
        <property type="nucleotide sequence ID" value="XM_001220914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDL0"/>
    <dbReference type="STRING" id="306901.Q2HDL0"/>
    <dbReference type="GeneID" id="4387549"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01694"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_5_1"/>
    <dbReference type="InParanoid" id="Q2HDL0"/>
    <dbReference type="OMA" id="MRVAMYY"/>
    <dbReference type="OrthoDB" id="2148442at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050019">
        <property type="term" value="F:L-arabinitol 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019568">
        <property type="term" value="P:arabinose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF12">
        <property type="entry name" value="L-ARABINITOL 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="15">
        <location>
            <begin position="63"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="14">
        <location>
            <begin position="213"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAQ93459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="386" mass="41014" checksum="5413FE9F0F9AD564" modified="2006-03-21" version="1">MNGTKTVNGANGTNGINGTNGTNGKLKAAKANIGVFTNPKHDLWISEATPTLESVQKGEELKEGQVTIAIRSTGICGSDVHFWKHGCIGPMIVGCDHILGHESAGEIVAVHPGVTSLKVGDRVAVEPQVICNACEPCLTGRYNGCEAVDFLSTPPVPGLLRRYVNHPAVWCHKIGDMSYEDGAMLEPLSVALAGLHRAEVRLGDPVLVCGAGPIGLITMLCAKAAGACPLVITDIDEGRLRFAKEICPEVITHKVERMSAEEAAKAVVASFGGIEPAVALECTGVESSIAAAIWAVKFGGKVFVIGVGKNEIQIPFMRASVREVDLQFQYRYSNTWPRAIRLVQNGVVDLSRLVTHRFGLEDALKAFDAASDPKTGAIKVMIQSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDR3</accession>
    <name>Q2HDR3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="20">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CHGG_01641</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 20">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="18">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 20">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Mitochondrion inner membrane</location>
            <topology evidence="1 20">Peripheral membrane protein</topology>
            <orientation evidence="1 20">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="20"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220862.1">
        <property type="nucleotide sequence ID" value="XM_001220861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDR3"/>
    <dbReference type="FunCoup" id="Q2HDR3">
        <property type="interactions" value="643"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HDR3"/>
    <dbReference type="GeneID" id="4387743"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01641"/>
    <dbReference type="eggNOG" id="KOG2403">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_6_1_1"/>
    <dbReference type="InParanoid" id="Q2HDR3"/>
    <dbReference type="OMA" id="PTGIWRM"/>
    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045273">
        <property type="term" value="C:respiratory chain complex II (succinate dehydrogenase)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
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    </dbReference>
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        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8 18 20" id="KW-0274">FAD</keyword>
    <keyword evidence="6 18 20" id="KW-0285">Flavoprotein</keyword>
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    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 20" id="KW-0813">Transport</keyword>
    <keyword evidence="5 20" id="KW-0816">Tricarboxylic acid cycle</keyword>
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        <location>
            <begin position="59"/>
            <end position="454"/>
        </location>
    </feature>
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        <location>
            <begin position="509"/>
            <end position="644"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="64"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="437"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
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        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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            <begin position="453"/>
            <end position="454"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57692"/>
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            <position position="95"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ93406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="644" mass="70529" checksum="BC3611AB68E61E0A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDZ0</accession>
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        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">CHGG_01564</name>
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    <organism evidence="4 5">
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000001056">
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    </dbReference>
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    </dbReference>
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    <dbReference type="PANTHER" id="PTHR38849">
        <property type="entry name" value="SMALL SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38849:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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        </location>
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            <begin position="18"/>
            <end position="621"/>
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            <end position="246"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="554"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ93329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="621" mass="68698" checksum="6ACB665DC0EEF273" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEA4</accession>
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        <recommendedName>
            <fullName evidence="2">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">CHGG_01450</name>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001220670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEA4"/>
    <dbReference type="GeneID" id="4387714"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01450"/>
    <dbReference type="eggNOG" id="ENOG502RS68">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_619631_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HEA4"/>
    <dbReference type="OrthoDB" id="5095644at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718">
        <property type="entry name" value="OS01G0519700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718:SF3">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="2">
        <location>
            <begin position="48"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="442" mass="49692" checksum="CF5CA0B87161542C" modified="2006-03-21" version="1">MIAKKMLEKAKVYHTVKWSKSDPTKPEGMFWALDWSKNEWKLSPWLQLYDNTYKTNNKKLAFFQVAGINAMGKIYSCAFGFINNERQEGFDWLMDQVNACRESIDANPPAVTITDYDKAMKSAISRVYPDADQQLCIFHVNKNVVLNIKRKWKKDVVEQLLAAEGAPATQSAVNEEEELDGEDWAVVTRLNNLATCEGLLERLPETVEYSRAGLYKLWAHAIYIIKHLEETYMTASIVKQWATCYTNQRLNFGHRTTSPVESMNRYLKSFVVNGNSTVFEAITQSLNMVKEMEVNLKEGRAQETGRLKREYLGKAWLGEAPYNVASRALKKISLQYRHMLGAIKTPERPNPAPLTPCTGQFTKQPTDSAVFASDPKAPRSTAPLSTPRESLLTPSIHADRPQWDGVDLATEDASDHANAEQPRKTISGLEMAVAASRGACGG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-06-02" modified="2025-02-05" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEW6</accession>
    <name>CHEC_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chaetoglobosin A biosynthesis cluster protein C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cheC</name>
        <name type="ORF">CHGG_01238</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2013" name="J. Am. Chem. Soc." volume="135" first="7371" last="7377">
            <title>Combinatorial generation of complexity by redox enzymes in the chaetoglobosin A biosynthesis.</title>
            <authorList>
                <person name="Ishiuchi K."/>
                <person name="Nakazawa T."/>
                <person name="Yagishita F."/>
                <person name="Mino T."/>
                <person name="Noguchi H."/>
                <person name="Hotta K."/>
                <person name="Watanabe K."/>
            </authorList>
            <dbReference type="PubMed" id="23611317"/>
            <dbReference type="DOI" id="10.1021/ja402828w"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2021" name="Fungal Biol." volume="125" first="201" last="210">
            <title>Functional analysis of a chaetoglobosin A biosynthetic regulator in Chaetomium globosum.</title>
            <authorList>
                <person name="Cheng M."/>
                <person name="Zhao S."/>
                <person name="Liu H."/>
                <person name="Liu Y."/>
                <person name="Lin C."/>
                <person name="Song J."/>
                <person name="Thawai C."/>
                <person name="Charoensettasilp S."/>
                <person name="Yang Q."/>
            </authorList>
            <dbReference type="PubMed" id="33622536"/>
            <dbReference type="DOI" id="10.1016/j.funbio.2020.10.010"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4 6">Part of the gene cluster that mediates the biosynthesis of chaetoglobosin A which has a unique inhibitory activity against actin polymerization in mammalian cells (PubMed:23611317, PubMed:33622536). Chaetoglobosin A and its intermediates are involved in the morphological differentiation of C.globosum (PubMed:33622536). The first step of the pathway is the synthesis of prochaetoglobosin I via condensation of one acetyl-CoA, 8 malonyl-CoA, and a L-tryptophan molecule by the PKS-NRPS hybrid synthetase cheA, followed by reduction of backbone double bond to install desired geometry by the enoyl reductase cheB (PubMed:23611317). Further multiple oxidation steps performed by the cytochrome P450 monooxygenases cheE and cheG, as well as by the FAD-linked oxidoreductase cheF, lead to the formation of chaetoglobosin A (PubMed:23611317). Depending on the order of action of these reductases, distinct intermediates can be identified (PubMed:23611317). Within the pathway, the cytochrome P450 monooxygenase cheE catalyzes a stereospecific epoxidation on prochaetoglobosin I, cytoglobosin D, and chaetoglobosin J intermediates (PubMed:23611317). The FAD-linked oxidoreductase cheF performs dehydrogenation of the C-20 hydroxyl groups in the 20-dihyrochaetoglobosin A and cytoglobosin D intermediates (PubMed:23611317). Finally, the cytochrome P450 monooxygenase cheG can catalyze the stereospecific dihydroxylation of prochaetoglobosin I and prochaetoglobosin IV at C-19 and C-20, respectively (PubMed:23611317). The Diels-Alderase cheD may play a role in the post-PKS-NRPS biosynthetic steps catalyzing Diels-Alder cyclization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4">Expression is positively regulated by the cluster-specific transcription factor cheR that binds directly to an asymmetric direct repeat present in the promoter.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220459.1">
        <property type="nucleotide sequence ID" value="XM_001220458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEW6"/>
    <dbReference type="SMR" id="Q2HEW6"/>
    <dbReference type="GeneID" id="4387644"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01238"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_1_1"/>
    <dbReference type="InParanoid" id="Q2HEW6"/>
    <dbReference type="OMA" id="RRTELKC"/>
    <dbReference type="OrthoDB" id="4589250at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000452798" description="Chaetoglobosin A biosynthesis cluster protein C">
        <location>
            <begin position="1"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="HTH CENPB-type" evidence="1">
        <location>
            <begin position="51"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="23611317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="33622536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="33622536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="33622536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ93003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="409" mass="46085" checksum="B4FE1B5DDA001E57" modified="2006-03-21" version="1">MRSPPREARLRMAVEAIGKNKNLSIRAAARQYNVPEATIRHRCTGRSARRDLPANSRKLTDLEERTIVQYILELDARAFPPRLRGVEDMANHLLRERDAPPVGKLWAHNFVKRQPQLRTRRTRRYDYQRAKCEDPKVIGEWFTLVQDAKAKYGIVDDDVYNFDETGLMMGIIFAGQAYGRLIDELMRAHINHITKLEFLCAFREAFFASMTEKNIQGGFSGAGIVPFDPERVLSKLDVKLHTPTHPDSRPGTAQPWASKTPYNAQETRSQSDFIKTRISSYQNSSPASVLVAVDQLTKGATAVMHQVALLQSEVSSLRKANEPLSKRRKAKRTRIQLGGPLTVQDAQDPLDQRDVGKGALQETQPDSSGAGGARAKVRRCNSCCKVGESASLAYMRRSLIIYVRSYNDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG67</accession>
    <name>Q2HG67_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_00787</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220008.1">
        <property type="nucleotide sequence ID" value="XM_001220007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG67"/>
    <dbReference type="STRING" id="306901.Q2HG67"/>
    <dbReference type="GeneID" id="4386886"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00787"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002572_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HG67"/>
    <dbReference type="OMA" id="DTMSITH"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045009">
        <property type="term" value="C:chitosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030476">
        <property type="term" value="P:ascospore wall assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097271">
        <property type="term" value="P:protein localization to bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF16">
        <property type="entry name" value="CHITIN SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ92552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="502" mass="57092" checksum="ACFDC8A546BD0719" modified="2006-03-21" version="1">MVKDHSTPPEQVEAFSYVAVASGSKRHNMAKIYSGFYDYGAKSAIPLEKQQRVPMMVVVKCGTPDEATKSKPGNRGKRDSQIILMSFLQKVMFDERMTELEYEMFNGLWKVTGISPDFYEIVLMVDADTKVFPDSLTHMISAMVKDPEIMGLCGETKIANKRASWVSAIQVFEYFISHHLAKSFESVFGGVTCLPGCFCMYRIKAPKGAQNYWVPILANPDVVEHYSENVVDTLHKKNLLLLGEDRYLSTLMLRTFPKRKQVFVPQAVCKTTVPDTFMVLLSQRRRWINSTIHNLMELVLVRDLCGTFCFSMQFIVFIELIGTLVLPAAIAFTFYVGKFLAKPGPSPKFIRTEANMSFFPVIISIINSPPQIIPLILLGLILGLPAVLIVVTAHSWSYVVWMFIYLLSLPVWNFILPTYSFWKFDDFSWGDTRKTAGEKTKKAGIEYEGEFDSSKITMKRWAEFERDRRTRNNSYWGSTENIVGGGSQQMGHGPYDGYYSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG98</accession>
    <name>Q2HG98_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_00756</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219977.1">
        <property type="nucleotide sequence ID" value="XM_001219976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG98"/>
    <dbReference type="FunCoup" id="Q2HG98">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HG98"/>
    <dbReference type="GeneID" id="4386677"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00756"/>
    <dbReference type="eggNOG" id="ENOG502QPSU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030903_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HG98"/>
    <dbReference type="OMA" id="DINTGLR"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF18">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, PHENYLALANINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="7">
        <location>
            <begin position="57"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ92521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="372" mass="40575" checksum="14D1D8021866D1B4" modified="2006-03-21" version="1">MSSFYLENKNVGNKAESEDWRIRGYNPLTPPGLLQHEIAQTPESKKTVLESREEAVAVVNGTDEKQRLLVVIGPCSIHDPKAALEYCDMLLKEKEKHKDELLIVMRSYLEKPRTTVGWKGLINDPDIDNSFNINKGLRLSRQLFVDLTSRGMPIASEMLDTISPQFLADLLSVGAVGARTTESQLHRELASGLSFPVGFKNGTDGSLTVAVDAIGAVRHPHHFLSVTKPGVVAIVGTVGNEDCFVILRGGTRGTNYDAQSIAEAKASLQKAGVRQRLMVDCSHGNSLKNHKNQPKVAATLAEQLEKGEDAIMGVMIESHINEGNQKVPKEGKDGLKYGVSITDACIGWEDTVQVLDLLANAVKKRREEGVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGF6</accession>
    <name>Q2HGF6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein BZZ1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_00698</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in endocytosis and trafficking to the vacuole. Functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BZZ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219919.1">
        <property type="nucleotide sequence ID" value="XM_001219918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGF6"/>
    <dbReference type="FunCoup" id="Q2HGF6">
        <property type="interactions" value="300"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HGF6"/>
    <dbReference type="GeneID" id="4386724"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00698"/>
    <dbReference type="eggNOG" id="KOG3565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015390_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HGF6"/>
    <dbReference type="OMA" id="FCRECHY"/>
    <dbReference type="OrthoDB" id="8783038at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106006">
        <property type="term" value="F:cytoskeletal protein-membrane anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20824">
        <property type="entry name" value="C1_SpBZZ1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000060">
        <property type="entry name" value="Actin polymerization protein Bzz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000161">
        <property type="entry name" value="Actin polymerization protein Bzz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000040">
        <property type="entry name" value="Actin polymerization protein Bzz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF21">
        <property type="entry name" value="PROTEIN NERVOUS WRECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="F-BAR" evidence="14">
        <location>
            <begin position="8"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="13">
        <location>
            <begin position="375"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="634"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="423"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="595"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="91"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="429"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="533"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ92463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="692" mass="76175" checksum="B28ECB0D2C827A98" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH00</accession>
    <name>Q2HH00_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219725.1">
        <property type="nucleotide sequence ID" value="XM_001219724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH00"/>
    <dbReference type="GeneID" id="4387817"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00504"/>
    <dbReference type="HOGENOM" id="CLU_634584_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HH00"/>
    <dbReference type="OrthoDB" id="10334664at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="432" mass="46353" checksum="16773D7BB56017BE" modified="2006-03-21" version="1">MAVARGEIKQRGSRKLAAAAWSTSGEVSPRLLENEPGRGFGKPRDCGRQTQVTAHREVLNSPRTLGPRRFVKPPGKGGVGGGVRVRKTSGSHWEEPLNSMIGVRLSQQQFARAGTRSYESGSNGMWSVLRVRDLGWAEWGVRKRELGPRSKGTASLCETCQAAQRDGVVSQETVNGRSGNRSGGILGLARKQIELWSSTAPSTSQGPRTVPGWWREVRGVAGQSEARKRIPCRSQTGKKDVSTGTCDTGQRGVTGLTMVDSGREAGLILGKLAIPPHGWRPRKVRQSMDAKPKLGSTKTCNARNKRAGATSTTSASSNTAGLSAFGRRKTPSRGDERRSGPADALESHPSGSSEECIKAAEAVAIQPQAGRVGRVFIPPDRQSAGRGAMHERAWWAGSRNSGATSSQRPLQHCDPNFGRAASWTRVRSRTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH72</accession>
    <name>Q2HH72_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RecF/RecN/SMC N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_00432</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219653.1">
        <property type="nucleotide sequence ID" value="XM_001219652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH72"/>
    <dbReference type="FunCoup" id="Q2HH72">
        <property type="interactions" value="724"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HH72"/>
    <dbReference type="GeneID" id="4387680"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00432"/>
    <dbReference type="eggNOG" id="KOG0250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009063_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HH72"/>
    <dbReference type="OMA" id="FMCHRSL"/>
    <dbReference type="OrthoDB" id="10072614at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="14">
        <location>
            <begin position="145"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="380"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="635"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="733"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ92197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1053" mass="120595" checksum="F41A29BB684E8D1C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHG8</accession>
    <name>Q2HHG8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Condensin complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_00336</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CND1 (condensin subunit 1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219557.1">
        <property type="nucleotide sequence ID" value="XM_001219556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHG8"/>
    <dbReference type="FunCoup" id="Q2HHG8">
        <property type="interactions" value="491"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HHG8"/>
    <dbReference type="GeneID" id="4388256"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00336"/>
    <dbReference type="eggNOG" id="KOG0414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001867_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HHG8"/>
    <dbReference type="OMA" id="CPLEKLW"/>
    <dbReference type="OrthoDB" id="436262at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="EnsemblFungi"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000272">
        <property type="entry name" value="Condensin complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000920">
        <property type="entry name" value="Condensin complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007673">
        <property type="entry name" value="Condensin_cplx_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024324">
        <property type="entry name" value="Condensin_cplx_su1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12922">
        <property type="entry name" value="Cnd1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Condensin_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="6 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 N-terminal" evidence="13">
        <location>
            <begin position="141"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="12">
        <location>
            <begin position="1059"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="838"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="934"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="840"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="861"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="879"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="941"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="964"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ92101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1243" mass="138355" checksum="E4320812EF3EFBF6" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHQ7</accession>
    <name>Q2HHQ7_CHAGB</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CHGG_00247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ92012.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="4388029"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00247"/>
    <dbReference type="HOGENOM" id="CLU_3124900_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHQ7"/>
    <dbReference type="Proteomes" id="UP000001056">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="50" mass="4933" checksum="3AD569D107B93DCE" modified="2006-03-21" version="1">MLDSAVRQSVGQGSTQGPPGSVSGAPGQPVPRPVEIIPARLGSLAEPAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHW8</accession>
    <name>Q2HHW8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219407.1">
        <property type="nucleotide sequence ID" value="XM_001219406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHW8"/>
    <dbReference type="STRING" id="306901.Q2HHW8"/>
    <dbReference type="GeneID" id="4386624"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00186"/>
    <dbReference type="eggNOG" id="ENOG502S0ES">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1677660_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHW8"/>
    <dbReference type="OrthoDB" id="5338458at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF1">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle" evidence="2">
        <location>
            <begin position="81"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="157" mass="18033" checksum="99ED2B96D2986AF2" modified="2006-03-21" version="1">MATAGLPTPPGPAPNRTSSRIGHRRGYKKYDTEDYSTRTLFLFQDCWLGPSRKRQRRQGRMRYELDDAPSIIVNSRKTLMVGDAKAVMEFYGRSFTEIQQDACKEVAKAFVKILCPKKRRTFPYAKGDAAAPDWWPDRVRHVEPDHLRKKGAYPGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI42</accession>
    <name>Q2HI42_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Maltose/galactoside acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_00112</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219333.1">
        <property type="nucleotide sequence ID" value="XM_001219332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HI42"/>
    <dbReference type="STRING" id="306901.Q2HI42"/>
    <dbReference type="GeneID" id="4388056"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00112"/>
    <dbReference type="eggNOG" id="KOG4750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_698292_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HI42"/>
    <dbReference type="OMA" id="EDGHACN"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF54">
        <property type="entry name" value="ACETYLTRANSFERASE, CYSE_LACA_LPXA_NODL FAMILY (AFU_ORTHOLOGUE AFUA_2G08430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Maltose/galactoside acetyltransferase" evidence="5">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
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        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ91877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="395" mass="42717" checksum="242A71D05095CC07" modified="2006-03-21" version="1">MSSDSTIASTPNETDIAYFPEVVFPAGNSDFRAARNRCARACREFNTTPDDADPEERSQKWLDIVRPDRDRTEDSVLAVTHDQTFANPALKAKTPFIKPPVYIDYGVRLHVGGSTFINRNCMIMDTPVADVVIGEGCNIGSNCCIIGVTHPVRLDERLQRHSIGQPVTIGNDVWIGANVTILGGVTIGDGAVIGACSLVKRDVPPMSVAFGVPARVVRFLKDVKPALNSSSVMAHTMADGMRLGNRLPMRGQFDPGSRDSSGGGEYQEDGHACNGSVVEGDGLLDFDPLGVDTDVDMDGPLPSGRRFSGGSGSTAHSVLHDVGLRDRLGRGSVRDREVRALLLPRRRHQQRRRQRWDVEAAAITAVVIALLMVFFFAGVYLGASKISFGPDLGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI48</accession>
    <name>Q2HI48_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219327.1">
        <property type="nucleotide sequence ID" value="XM_001219326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HI48"/>
    <dbReference type="GeneID" id="4387906"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00106"/>
    <dbReference type="eggNOG" id="ENOG502SH6B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011353_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HI48"/>
    <dbReference type="OMA" id="ASPWRHM"/>
    <dbReference type="OrthoDB" id="5392263at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209478" evidence="2">
        <location>
            <begin position="21"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="476"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="632"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1025" mass="113620" checksum="D54353D27607C023" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN41</accession>
    <name>Q2GN41_CHAGB</name>
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        <recommendedName>
            <fullName evidence="7">Transcription activator GCR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_10613</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228540.1">
        <property type="nucleotide sequence ID" value="XM_001228539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN41"/>
    <dbReference type="GeneID" id="4396808"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10613"/>
    <dbReference type="eggNOG" id="ENOG502RS66">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009209_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GN41"/>
    <dbReference type="OMA" id="ESGNEWC"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060963">
        <property type="term" value="P:positive regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.20">
        <property type="entry name" value="Centromere DNA-binding protein complex CBF3 subunit, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052146">
        <property type="entry name" value="HOT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038279">
        <property type="entry name" value="Ndc10_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031872">
        <property type="entry name" value="NDC10_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022210">
        <property type="entry name" value="TF_GCR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37784:SF2">
        <property type="entry name" value="HIGH-OSMOLARITY-INDUCED TRANSCRIPTION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37784">
        <property type="entry name" value="PROTEIN MSN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12550">
        <property type="entry name" value="GCR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16787">
        <property type="entry name" value="NDC10_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208287" description="Transcription activator GCR1-like domain-containing protein" evidence="2">
        <location>
            <begin position="41"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="Ndc10" evidence="4">
        <location>
            <begin position="253"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription activator GCR1-like" evidence="3">
        <location>
            <begin position="732"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="664"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ84209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="839" mass="94630" checksum="CAEFC3AB6CCB7FE0" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNZ1</accession>
    <name>Q2GNZ1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ornithine carbamoyltransferase, mitochondrial</fullName>
            <ecNumber evidence="4">2.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ornithine transcarbamylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_10313</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>carbamoyl phosphate + L-ornithine = L-citrulline + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228240.1">
        <property type="nucleotide sequence ID" value="XM_001228239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNZ1"/>
    <dbReference type="FunCoup" id="Q2GNZ1">
        <property type="interactions" value="577"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GNZ1"/>
    <dbReference type="GeneID" id="4396196"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10313"/>
    <dbReference type="eggNOG" id="KOG1504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_3_0_1"/>
    <dbReference type="InParanoid" id="Q2GNZ1"/>
    <dbReference type="OMA" id="DGNNVCN"/>
    <dbReference type="OrthoDB" id="10252326at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903269">
        <property type="term" value="C:ornithine carbamoyltransferase inhibitor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019240">
        <property type="term" value="P:citrulline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000017">
        <property type="entry name" value="Ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000009">
        <property type="entry name" value="Ornithine carbamoyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753">
        <property type="entry name" value="ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753:SF3">
        <property type="entry name" value="ORNITHINE TRANSCARBAMYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase carbamoyl-P binding" evidence="13">
        <location>
            <begin position="29"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase Asp/Orn-binding" evidence="12">
        <location>
            <begin position="193"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ83909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="359" mass="38406" checksum="CB8A0B1F412FAADF" modified="2006-03-21" version="1">MSSRAACRTIKSAMAHIQTRSLSSASGPRHLLSISDLSPAEFTKLVLNASSHKAAVKAAFAAGEQPPKPLHGSLTGKTVAMMFNKRSTRTRVSTEAAVQMMSGHPMFLGKDDIQLGVNESLYDTSVVISSMTSCMVARVGAHKEVADLAAHSSVPVINALSSDYHPLQTIADFQTIHESFPGRTPSDASLGLEGLKVAWVGDSNNVLFDLAIGCVKMGLDIAVASPAGYGIPAAMKQVILAAGEGVASPGRLTETQVPEEAIRDADILVTDTWVSMGQEEESKKRMKAFAGYQITNELAKRGGAKPDWKFMHCLPRHPEEVEDEVFYGSRSLVFPEAENRLWAAAAALEAFVVNKGKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GP77</accession>
    <name>Q2GP77_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_10227</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228154.1">
        <property type="nucleotide sequence ID" value="XM_001228153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GP77"/>
    <dbReference type="STRING" id="306901.Q2GP77"/>
    <dbReference type="GeneID" id="4397056"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10227"/>
    <dbReference type="eggNOG" id="KOG1488">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009803_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GP77"/>
    <dbReference type="OMA" id="RTREIWG"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF48">
        <property type="entry name" value="MEIOTIC COILED-COIL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="395"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="458"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="494"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="683"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="754"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="135"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="764"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ83823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="774" mass="85053" checksum="8D7836B77B0E678A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GP92</accession>
    <name>Q2GP92_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">U6 snRNA-associated Sm-like protein LSm1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LSM1</name>
        <name evidence="14" type="ORF">CHGG_10212</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a donut shape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228139.1">
        <property type="nucleotide sequence ID" value="XM_001228138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GP92"/>
    <dbReference type="FunCoup" id="Q2GP92">
        <property type="interactions" value="349"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GP92"/>
    <dbReference type="GeneID" id="4396977"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10212"/>
    <dbReference type="eggNOG" id="KOG1782">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GP92"/>
    <dbReference type="OMA" id="RTWDQFA"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01728">
        <property type="entry name" value="LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000021">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034104">
        <property type="entry name" value="Lsm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF8">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="44"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ83808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="182" mass="20038" checksum="172DCC6348DB7C0B" modified="2006-03-21" version="1">MENLTISDPPPPPMQQQHGGPGGMPPALGRPPPPPQQLPAQMFTTAAQLLDLTDKKLMLALRDGRKLVGILRSWDQFANLVLQSTKERIFVPPGTAPDQVRGLYADVDRGLFLVRGENVLLLGEIDLDKEDDAPPGYDLADVELVQSLAKQRKQQDKIKEKTKVKMLAKEGFEGENLGEVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPF6</accession>
    <name>Q2GPF6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228075.1">
        <property type="nucleotide sequence ID" value="XM_001228074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPF6"/>
    <dbReference type="GeneID" id="4396869"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10148"/>
    <dbReference type="eggNOG" id="ENOG502T668">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_636440_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPF6"/>
    <dbReference type="OMA" id="VPNTHFE"/>
    <dbReference type="OrthoDB" id="5190749at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="373" mass="41036" checksum="17E183BE58471B1C" modified="2006-03-21" version="1">MAPSSRPPSLPSIPDIALDLDEKAQLLPELEEVLSSGAETSTTLDEEYDFRPSRSHSTRTQNSFHRRIVLPSRFLSISSSHAPTTLTTLLLSLRHHDVTCQTTPPPPKKPSTNPGPSSTTTPRRTPNCTSAPLGITLWRQFDLRAAEEGSVLSVVPNTHFEQAELAATVALHEASVTASAGRRGGAAPKRTLSKPKIVGSAAGKGASGGGVGAGAGVGEGWWEGAVYAADLERRVRALDWRVQDEIYELLSDRVQSSSNAFRRRDWRVVALTEVPGGELTDAPTGFRAFGEVKRGWFGFGKTRRLSVKAKRWPDMPVTEYRLILRGAETKTNDQGWGHYNRYSRPWRAADEKDIGDRRRWSSFTGKSEKYVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPM4</accession>
    <name>Q2GPM4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228007.1">
        <property type="nucleotide sequence ID" value="XM_001228006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPM4"/>
    <dbReference type="GeneID" id="4396765"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10080"/>
    <dbReference type="eggNOG" id="ENOG502SIR2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028280_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPM4"/>
    <dbReference type="OMA" id="NFQTTLW"/>
    <dbReference type="OrthoDB" id="68575at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF26">
        <property type="entry name" value="FMN REDUCTASE LOT6, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208459" description="Amine oxidase domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="50520" checksum="FB079CAF52B3F0BD" modified="2006-03-21" version="1">MVLTLRLASGLLAAATAVSATSWLPDIVTRDVAIIGGGASGAYAAIRLKEDFKKSIVLVEKAGRLGGHVSTYDDPKTGTPFDFGVQSFNDYGPARAFFERMGVAVGAAPRVALTSKYADFSSGAAVDFTPPSNEDRVAALGRFLNATAAYEEYFLPGYWNFPAPGKIPEDLLLPFGKFVEKYQLHAAVNQVFQITGMGTGDMMNALTLYVLGAFGQPMIRAFLGQGATFTPTSRRNIALYEAIQSRLGNDVLLNTESASGKVTIILARRLLMAIEPTPSNMAPFGLDLVEQSTFSKFRYSSIHAGVVSHPSLPRNVSLVNTPRAASPANYVALPKPNFNVRFDYLGGNSDLFRVLMVGDEQFDKAKAQAQVRQDFARLMKQGTVQPKTADPGGELEFRAWADHGAMHMNVPAKELKSGFIQKLYALQGRRDTWWTGGAFSVQFQAILWAFDDILLPKMFEKGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPY5</accession>
    <name>Q2GPY5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_09969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227896.1">
        <property type="nucleotide sequence ID" value="XM_001227895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPY5"/>
    <dbReference type="GeneID" id="4396110"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09969"/>
    <dbReference type="eggNOG" id="ENOG502R6DE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1434294_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPY5"/>
    <dbReference type="OMA" id="KDDECHP"/>
    <dbReference type="OrthoDB" id="5125452at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="167" mass="18776" checksum="B06BEF3231E95071" modified="2006-03-21" version="1">MLIRREGEEKDCHPQPDIDLCKKPWVSSNKVTWIIVGVVVGLLVVATSLVVLYFHFRRRKREKSEDVEDRHYRADYGLDELPVAGKPRPDQDMRSPDRSPSGFGRRSRDPLQVGSEPKYPPPGQLNGHLSAFDDGASSRSGNGSSYPPSVNPAWPKRESSQLKPQDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQ65</accession>
    <name>Q2GQ65_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_09889</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227816.1">
        <property type="nucleotide sequence ID" value="XM_001227815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQ65"/>
    <dbReference type="GeneID" id="4396912"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09889"/>
    <dbReference type="eggNOG" id="KOG1121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001248_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQ65"/>
    <dbReference type="OrthoDB" id="3934771at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="118"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="529"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="529"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ83485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="579" mass="64455" checksum="7EFB009A10889D3F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQB6</accession>
    <name>Q2GQB6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_09838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227765.1">
        <property type="nucleotide sequence ID" value="XM_001227764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQB6"/>
    <dbReference type="GeneID" id="4396937"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09838"/>
    <dbReference type="HOGENOM" id="CLU_2637852_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQB6"/>
    <dbReference type="OrthoDB" id="4074350at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ83434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8240" checksum="E770F169E86E46A0" modified="2006-03-21" version="1">MYLETMSMQFATNIVDAQNHSIALIESASQISFGLHYGSAGATAKMPGSLLFGGYDRNCVIGPILSLDADFRNPVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQI3</accession>
    <name>Q2GQI3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227698.1">
        <property type="nucleotide sequence ID" value="XM_001227697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQI3"/>
    <dbReference type="STRING" id="306901.Q2GQI3"/>
    <dbReference type="GeneID" id="4396646"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09771"/>
    <dbReference type="eggNOG" id="ENOG502S9FG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013727_5_2_1"/>
    <dbReference type="InParanoid" id="Q2GQI3"/>
    <dbReference type="OMA" id="CIDSEEP"/>
    <dbReference type="OrthoDB" id="1421156at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718">
        <property type="entry name" value="OS01G0519700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718:SF10">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="1">
        <location>
            <begin position="190"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="504" mass="56429" checksum="5AC4B836590B94B5" modified="2006-03-21" version="1">MVKNGTKSGRACFRCAKGREYKPQANPETHESKRRKTSTQFTGCKFQLAARPLPDGRWAVKLPDGPAALHNHGWSDPTAFAGARADALAPFEQEVIKLSNSGSRPAQILAAIQAEQRGIHGQDIINLLQRHRRAELRGRSPLQCLYEDYLKPEASKFVWEDTRDSLGHVISLTIAPKSGLQLLKQNPDLLLLDSTYKTNHHNRPLFNACGVTSGNKTFNWAVTFMSGEKEGDYSCALAALIRILQNEGIKVPGLIVTDRELALLNALNNSAWVSIPHLLCRWHVNMNVLAKARRHFPAATKHGSEYRRHPTFKAFLKEWNALLASVTEDDFNKNLAKFRTPGRHPDAAVDYAVATWIEPWKATHGLPCRHILYRHLTGDEPVTIQQIHKHWWLWRPQEQQHVGDDDSRNPNVEVVGIMPMPDIPLDPRQVKGKGRPVGAIATTSAASRKKGAGVNSTKRLPSAFEYNIEDELTTAVPAPKQQQQQHVTNLLQDPVLLGFSFGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQY5</accession>
    <name>Q2GQY5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_09619</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227546.1">
        <property type="nucleotide sequence ID" value="XM_001227545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQY5"/>
    <dbReference type="FunCoup" id="Q2GQY5">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GQY5"/>
    <dbReference type="GeneID" id="4396398"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09619"/>
    <dbReference type="eggNOG" id="KOG2204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GQY5"/>
    <dbReference type="OMA" id="WDCVPQG"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF103">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSIDASE MNL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="36"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="454"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="700"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="700"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="720"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="747"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="771"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="523"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="640"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="835"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="925"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="597"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ83215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="934" mass="104811" checksum="BE7D80794704BFF4" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQZ3</accession>
    <name>Q2GQZ3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_09611</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227538.1">
        <property type="nucleotide sequence ID" value="XM_001227537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQZ3"/>
    <dbReference type="STRING" id="306901.Q2GQZ3"/>
    <dbReference type="GeneID" id="4396746"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09611"/>
    <dbReference type="eggNOG" id="KOG0139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_4_4_1"/>
    <dbReference type="InParanoid" id="Q2GQZ3"/>
    <dbReference type="OMA" id="YQCEKMG"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME_B5_2"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="2"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="82"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ83207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="527" mass="58739" checksum="EB56DB8B21677D41" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GR67</accession>
    <name>Q2GR67_CHAGB</name>
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        <recommendedName>
            <fullName evidence="10">Cytomegalovirus gH-receptor family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_09537</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227464.1">
        <property type="nucleotide sequence ID" value="XM_001227463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GR67"/>
    <dbReference type="GeneID" id="4395191"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09537"/>
    <dbReference type="eggNOG" id="KOG2490">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003655_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GR67"/>
    <dbReference type="OMA" id="TCCVLMY"/>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="883"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="190"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="410"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="422"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ85523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1006" mass="110976" checksum="B70E721EF0A81F1E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRB9</accession>
    <name>Q2GRB9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ecp2 effector protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_09485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cerato-platanin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227412.1">
        <property type="nucleotide sequence ID" value="XM_001227411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRB9"/>
    <dbReference type="STRING" id="306901.Q2GRB9"/>
    <dbReference type="GeneID" id="4395913"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09485"/>
    <dbReference type="eggNOG" id="ENOG502SHQD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083928_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GRB9"/>
    <dbReference type="OMA" id="HASKCKD"/>
    <dbReference type="OrthoDB" id="5370830at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010829">
        <property type="entry name" value="Cerato-platanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38850">
        <property type="entry name" value="CERATO-PLATANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38850:SF2">
        <property type="entry name" value="CERATO-PLATANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07249">
        <property type="entry name" value="Cerato-platanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208945" description="Ecp2 effector protein domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ85471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="22403" checksum="38581CD1C0CBD014" modified="2006-03-21" version="1">MFALASLAVGLLATFVAGELRGITPHDMYSSSIGVLGCKINTNRVAYWPMSVDCNNICVRVSYGGRSVDLLRIDQSGGAYDISYDAYNFLVSGQSATAHPITGGAVDMDVQNVAASNCVQHLKAGGLPLSASNSMNYVASCLGQPNSWVAKNSRLFNIQDPVCHWGYDEQCSVNLAVSNQPSCSHALGFTNGRLPDTVFNIQYGTGAVVAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRE1</accession>
    <name>Q2GRE1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_09463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227390.1">
        <property type="nucleotide sequence ID" value="XM_001227389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRE1"/>
    <dbReference type="GeneID" id="4395533"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09463"/>
    <dbReference type="HOGENOM" id="CLU_534188_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRE1"/>
    <dbReference type="OrthoDB" id="4580797at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ85449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="510" mass="56951" checksum="35575C980E84B789" modified="2006-03-21" version="1">MPSPQHRRLTQGATLPAAAPANPLPASSVSMPRPFSPPPRGEPAASPPRRPRSCRATLCRVVILLLAALVGLNVLSLFASDPDSPRPPALSPPAAPRGVGKPAYYAFTRLSVVPDLIAITMAMGQIGRKVHRLPCVQRGWVYRMKAALSDMEEPAQLLESWLYGKNFPGKPSASVEGRLAAEALENVENICRAAPRDLDRFRELRWYEMTGHAQFTVDGVLHDHFAEFKNSTWAFHPDEEDLGQYDDLDLVGNVNQHEAADLNRTAARFLSSLHKKRLPELMRFCNMNGPPFQTPPEEFAILKAKFDSMLKQVEELSSSDWAEAARAGLEQYGIWDGPKPGLLRRAAFWVWGSGWEYPCRQTPISWEAQAGEQEDYYWMDPSPAGLRAYRDRKYADPYYYASALRCLLASQRVIREEVLPRVRKSQTGLAEAQAKYEKQVAEASQRLKHQIAELVAGRGWEFVERVQIGLTSEGHRVELSRAEAKGIPLTDVRNTTVWKAHVPAAGQQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRI2</accession>
    <name>Q2GRI2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine amidotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227349.1">
        <property type="nucleotide sequence ID" value="XM_001227348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRI2"/>
    <dbReference type="STRING" id="306901.Q2GRI2"/>
    <dbReference type="GeneID" id="4394797"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09422"/>
    <dbReference type="eggNOG" id="KOG3179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054974_0_2_1"/>
    <dbReference type="InParanoid" id="Q2GRI2"/>
    <dbReference type="OMA" id="VHVWGTS"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF4">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="119"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="283" mass="31419" checksum="68C7C2BB5BB22745" modified="2006-03-21" version="1">MTTQHVELDTESGRPTVRMMVLETDEPHPETKFRRGTFGEILHHHFAKAGDAHDPPLGIETDTRYVLTEKGGTMPKAHEFDNCEALLITGSVYDAHGNDPWDLDLLGLLKELWLKHPKMHFSGVCFGHQLLCRLLGSDIASAASTDWELGHSRINLSPLGQKLFQTDTPEVYLHQMHQDYVVAPPMAESSGGLLAPGTKVEVWGHSGHTKVQGVYIKGRLFTTQAHLAFDEGMVKRQIQMRVDSGSIEDLEHADRAAETAEMDHDGDVAAAAILRFFHDEGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRL8</accession>
    <name>Q2GRL8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_09386</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227313.1">
        <property type="nucleotide sequence ID" value="XM_001227312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRL8"/>
    <dbReference type="GeneID" id="4395352"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09386"/>
    <dbReference type="eggNOG" id="KOG0150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_308585_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRL8"/>
    <dbReference type="OrthoDB" id="191651at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="298"/>
            <end position="343"/>
        </location>
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            <begin position="403"/>
            <end position="435"/>
        </location>
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        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
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        <location>
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            <end position="686"/>
        </location>
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            <end position="766"/>
        </location>
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            <end position="795"/>
        </location>
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            <end position="109"/>
        </location>
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            <end position="230"/>
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            <end position="91"/>
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            <end position="202"/>
        </location>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="956" mass="104463" checksum="4B2C08DFD4DE4ED0" modified="2006-03-21" version="1"> </sequence>
</entry>
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        </submittedName>
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        </lineage>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_016583_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GRZ1"/>
    <dbReference type="OMA" id="NYIIHTG"/>
    <dbReference type="OrthoDB" id="3918848at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="MPP_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056812">
        <property type="entry name" value="RRM_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF11">
        <property type="entry name" value="DUF2433 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10360">
        <property type="entry name" value="DUF2433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25061">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="300"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding" evidence="3">
        <location>
            <begin position="526"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
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            <begin position="570"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25061"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ85249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="689" mass="72958" checksum="5F9FAAE000933424" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRZ8</accession>
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            <fullName evidence="4">hydroxyacid-oxoacid transhydrogenase</fullName>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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        <reaction evidence="1">
            <text>(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate</text>
            <dbReference type="Rhea" id="RHEA:23048"/>
            <dbReference type="ChEBI" id="CHEBI:11047"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="EC" id="1.1.99.24"/>
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    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + succinate semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:24734"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16724"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.24" evidence="4"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227183.1">
        <property type="nucleotide sequence ID" value="XM_001227182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRZ8"/>
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        <property type="interactions" value="463"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GRZ8"/>
    <dbReference type="GeneID" id="4395399"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_7_1"/>
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    <dbReference type="OMA" id="NLMGAGC"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047988">
        <property type="term" value="F:hydroxyacid-oxoacid transhydrogenase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="Fe-containing alcohol dehydrogenase"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
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    </dbReference>
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        <property type="entry name" value="ADH_Fe/GldA"/>
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        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
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    <dbReference type="InterPro" id="IPR042157">
        <property type="entry name" value="HOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF83">
        <property type="entry name" value="HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dehydroquinate synthase-like"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="94"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="10">
        <location>
            <begin position="316"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000813"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010005"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ85242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="514" mass="55436" checksum="4E19A49F7D6C6936" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GS10</accession>
    <name>Q2GS10_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH:ubiquinone oxidoreductase 30kDa subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_09244</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227171.1">
        <property type="nucleotide sequence ID" value="XM_001227170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GS10"/>
    <dbReference type="STRING" id="306901.Q2GS10"/>
    <dbReference type="GeneID" id="4395780"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09244"/>
    <dbReference type="eggNOG" id="KOG1713">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042628_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GS10"/>
    <dbReference type="OMA" id="PCRKNRF"/>
    <dbReference type="OrthoDB" id="37721at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.80:FF:000002">
        <property type="entry name" value="NADH dehydrogenase iron-sulfur protein 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="10">
        <location>
            <begin position="117"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="252"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ85230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="284" mass="32597" checksum="E55B9214A0010E20" modified="2006-03-21" version="1">MASKLYRNRALASALRPANPSVAVRHEAAVRCFATTARNSVALPKDVQNPRAAPRGQVGTPLQAPLVNPADKYQSKSDNMHKYGSWLMGCLPKYIQQFSVWKDELTIYIPPFRRYPDNTAAEFTQMSTITAVDFPTRDQRFEIVYNLLSVRHNSRIRVKTYADETTPVPSATPLFDGANWYEREVYDMFGVFFLNHPDLRRIMTDYGFEGHPLRKDFPVTGYTEIRWDEEKKRIVTEPLELTQAFRNFEGGSSAWEQIGPGVDRTPETFKLPTPKPEEKTEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSI3</accession>
    <name>Q2GSI3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_09071</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226998.1">
        <property type="nucleotide sequence ID" value="XM_001226997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSI3"/>
    <dbReference type="GeneID" id="4395331"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09071"/>
    <dbReference type="eggNOG" id="ENOG502SHNK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_6_3_1"/>
    <dbReference type="InParanoid" id="Q2GSI3"/>
    <dbReference type="OMA" id="CICMPAL"/>
    <dbReference type="OrthoDB" id="2496787at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF143">
        <property type="entry name" value="EXTRACELLULAR MEMBRANE PROTEIN CFEM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="14" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208567" description="CFEM domain-containing protein" evidence="16">
        <location>
            <begin position="22"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="17">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="27"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ85057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="372" mass="40397" checksum="B7143D3ECBD8A3C3" modified="2006-03-21" version="1">MRSTIWAAALALTGLAVRCWAQEMPACASDCLVKYLPDSKCDPTDMDCVCSDLTLMDNVGTCTLGACSLFDALAAKNATATLCKEPVRDRGNVAPIATAITGSMALAFVLLRVYESGFRKKEFHWADVWAILAMAHGMGKDIWTLPPDEITEVVKYTWVTQVSYIPAIILTKITVLCFFLHVFPAPGFQMACWGTIVHCVLFMVSTTIAAILACVPVESAWVAWTGTAEGVCFDNNAFWWAHSAINIVTDVWILALPIPQLLNLQLGTRKKVYLIMMFSVGLVVIECNISIMCCCMPAMLSFLRHVLPAVFGSTNRSKHYNYNNGGGGGEDGSYKIGGTGGTGGGRSALPLQRHPEERHPHGFVFSALWGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSL1</accession>
    <name>Q2GSL1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_09043</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226970.1">
        <property type="nucleotide sequence ID" value="XM_001226969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSL1"/>
    <dbReference type="STRING" id="306901.Q2GSL1"/>
    <dbReference type="GeneID" id="4394732"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09043"/>
    <dbReference type="eggNOG" id="KOG1097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022829_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GSL1"/>
    <dbReference type="OMA" id="YQPRQTM"/>
    <dbReference type="OrthoDB" id="7202371at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF37">
        <property type="entry name" value="ADENOSINE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="10">
        <location>
            <begin position="329"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ85029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="688" mass="78504" checksum="B0AD220804D53360" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSN7</accession>
    <name>Q2GSN7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_09017</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226944.1">
        <property type="nucleotide sequence ID" value="XM_001226943.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GSN7"/>
    <dbReference type="GeneID" id="4394993"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09017"/>
    <dbReference type="eggNOG" id="KOG2319">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_231356_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSN7"/>
    <dbReference type="OMA" id="CLRYMCL"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Amine oxidase" evidence="5">
        <location>
            <begin position="120"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="5">
        <location>
            <begin position="397"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="7">
        <location>
            <begin position="731"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="6">
        <location>
            <begin position="995"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1178"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1211"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1244"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1434"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1467"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1559"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1883"/>
            <end position="1915"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2030"/>
            <end position="2062"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2084"/>
            <end position="2112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ85003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="2188" mass="242419" checksum="33D2C3EFA8905FDE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTE6</accession>
    <name>Q2GTE6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_08758</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226685.1">
        <property type="nucleotide sequence ID" value="XM_001226684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTE6"/>
    <dbReference type="STRING" id="306901.Q2GTE6"/>
    <dbReference type="ESTHER" id="chagb-q2gte6">
        <property type="family name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="4395337"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08758"/>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_16_1_1"/>
    <dbReference type="InParanoid" id="Q2GTE6"/>
    <dbReference type="OMA" id="AELSWWY"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208583" description="AB hydrolase-1 domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="63"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ84744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="340" mass="37151" checksum="E89258414F9E05B7" modified="2006-03-21" version="1">MRLPSLLTLLSSATTTLAAAITPTNTTTNTTLPTPLSRLSPLKHLNTTRLRITYHESGPATGPPVLLLHGWPYSIDSYTHVAPALAAAGHRVIVPYLRGQGPTTFLRPDTPRSGEQAALGEDVVELMDGLGIGRAVLAGYDWGGRAANVVCALSPERCAGLVSVNGYLVQDLERAWVPLDVKIEAGFWYFYYFLTPRGEAALAEKPKEIARLVWERNSPLWRFTEEDLDRAAETFENPDYVSVVTHVYRHRLFYAPGDPDYAEAEKKLRKLPPITVPAVTLDGLADGNFPATDGTSSAKYFTGPRVHHQVEGAGHNLAQEKPQAFVDAVLEVVKLARDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTR3</accession>
    <name>Q2GTR3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_08641</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226568.1">
        <property type="nucleotide sequence ID" value="XM_001226567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTR3"/>
    <dbReference type="STRING" id="306901.Q2GTR3"/>
    <dbReference type="GeneID" id="4395408"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08641"/>
    <dbReference type="eggNOG" id="KOG4750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013964_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GTR3"/>
    <dbReference type="OMA" id="ACNNCIR"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03357">
        <property type="entry name" value="LbH_MAT_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF76">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="260"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="419"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="491"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ84627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="722" mass="79832" checksum="1375323A42C9C3CF" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTS3</accession>
    <name>Q2GTS3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fimbrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_08631</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226558.1">
        <property type="nucleotide sequence ID" value="XM_001226557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTS3"/>
    <dbReference type="FunCoup" id="Q2GTS3">
        <property type="interactions" value="534"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GTS3"/>
    <dbReference type="GeneID" id="4395869"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08631"/>
    <dbReference type="eggNOG" id="KOG0046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015284_3_0_1"/>
    <dbReference type="InParanoid" id="Q2GTS3"/>
    <dbReference type="OMA" id="WQLMRKN"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099079">
        <property type="term" value="C:actin body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120106">
        <property type="term" value="C:mitotic actomyosin contractile ring, distal actin filament layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044837">
        <property type="term" value="P:actomyosin contractile ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070649">
        <property type="term" value="P:formin-nucleated actin cable assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21294">
        <property type="entry name" value="CH_FIMB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21300">
        <property type="entry name" value="CH_FIMB_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21303">
        <property type="entry name" value="CH_FIMB_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000042">
        <property type="entry name" value="Fimbrin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000010">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000016">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000027">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="115"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="264"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="389"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="514"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ84617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="622" mass="69975" checksum="C80918901990212B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU54</accession>
    <name>Q2GU54_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226427.1">
        <property type="nucleotide sequence ID" value="XM_001226426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GU54"/>
    <dbReference type="GeneID" id="4395035"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08500"/>
    <dbReference type="eggNOG" id="ENOG502S6CD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_561392_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GU54"/>
    <dbReference type="OMA" id="MAKHLAC"/>
    <dbReference type="OrthoDB" id="5245206at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="486" mass="52828" checksum="A45E6B95F349FACC" modified="2006-03-21" version="1">MADDGNLGLRLAWAQTVGTFVGLLAIGLAVVALLIERVRRVQAADERRFTSEDSALGCFRAKSVSRWSSLWGDTTETLRLPTVAGLIEVGDRGGWTSSALDFMIENHPKETWVKLYESIMTSIACNAGVLEKDWRGEEEPVLTFLGRIEGNHHREHHVSGLWKARQSAYQSTPRKLLSLQRQLEPPAGQNQNPSFPSQQPATTPVPPRSGKRGLSRLTSTLIVRDKACISVTREELAALIIILGVALPNLESHRYVSGVGGFGLSIDINHADAAWSINIVQGSRLARHAPSMGSGYTTLMAKHLACGSVPFAKAQSWILSVYLTDEVLDALKAGSYVIDKRAFGGDSLEFLRRLPGDKLIDAFYGTENAAAAVSSSGVPNQQKHEAGSILHADRRLAGKWSRAVTEIAFGGLVPQASPNVVSATNCLGLYGPIDRSQTSNWPRNSGSVWEDSERNRAGKSSTRLRTWLVLPKCHDPSSTIFGCHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU76</accession>
    <name>Q2GU76_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_08478</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226405.1">
        <property type="nucleotide sequence ID" value="XM_001226404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GU76"/>
    <dbReference type="STRING" id="306901.Q2GU76"/>
    <dbReference type="ESTHER" id="chagb-q2gu76">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="4395238"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08478"/>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_10_5_1"/>
    <dbReference type="InParanoid" id="Q2GU76"/>
    <dbReference type="OMA" id="WIGATHD"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005142958" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="22"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ84464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="544" mass="57654" checksum="F04CD0AC943580A3" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUM3</accession>
    <name>Q2GUM3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_08331</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ87078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225987.1">
        <property type="nucleotide sequence ID" value="XM_001225986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUM3"/>
    <dbReference type="GeneID" id="4393199"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08331"/>
    <dbReference type="eggNOG" id="KOG1121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009123_10_1_1"/>
    <dbReference type="InParanoid" id="Q2GUM3"/>
    <dbReference type="OMA" id="FKCFAHT"/>
    <dbReference type="OrthoDB" id="5056142at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="6">
        <location>
            <begin position="689"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ87078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="775" mass="87883" checksum="5E0DAEFEB3FAEFF6" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV22</accession>
    <name>Q2GV22_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225838.1">
        <property type="nucleotide sequence ID" value="XM_001225837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV22"/>
    <dbReference type="GeneID" id="4393343"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08182"/>
    <dbReference type="HOGENOM" id="CLU_1855044_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GV22"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="138" mass="15530" checksum="6930701CFF3D463C" modified="2006-03-21" version="1">MRPCNIDKQISKQQAEPWSRKAARRSLDVHELGIEAVRLRASQTLAGNNPPHRYSAVISKARLAGAILHAQEHRDLPTPVSNPISTPQPGEQSTEWCFSPRSATMVYAPYNASAVDRWKGRTHPVLLRSRIAGKSWWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV30</accession>
    <name>Q2GV30_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_08174</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225830.1">
        <property type="nucleotide sequence ID" value="XM_001225829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV30"/>
    <dbReference type="STRING" id="306901.Q2GV30"/>
    <dbReference type="GeneID" id="4393177"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08174"/>
    <dbReference type="eggNOG" id="ENOG502SEEP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006409_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GV30"/>
    <dbReference type="OMA" id="IDDYEVM"/>
    <dbReference type="OrthoDB" id="5569911at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056703">
        <property type="entry name" value="DUF7801"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029191">
        <property type="entry name" value="Uds1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25078">
        <property type="entry name" value="DUF7801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15456">
        <property type="entry name" value="Uds1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Up-regulated during septation protein 1" evidence="3">
        <location>
            <begin position="88"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7801" evidence="4">
        <location>
            <begin position="825"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="617"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="679"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="958"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="513"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="882"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="627"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="987"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ86921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1035" mass="114030" checksum="7A96FC116F6B4A6F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVB2</accession>
    <name>Q2GVB2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_08092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225748.1">
        <property type="nucleotide sequence ID" value="XM_001225747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVB2"/>
    <dbReference type="STRING" id="306901.Q2GVB2"/>
    <dbReference type="GeneID" id="4394567"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08092"/>
    <dbReference type="eggNOG" id="KOG0620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_22_1"/>
    <dbReference type="InParanoid" id="Q2GVB2"/>
    <dbReference type="OMA" id="KRVRVWY"/>
    <dbReference type="OrthoDB" id="4577454at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ86839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="39121" checksum="55630D43B31DF253" modified="2006-03-21" version="1">MSELNPNLYTVAWIAPLEIEVQAGLHMFDHIHPGRFRTSRGDDYLFYGGDICGHNVVLVTLPAGQEYGTGSAAALASQVKKFFPYLRFGLLVGVAAGLPNLSLSPPRDIRLGDILVAFPEGESPGVVAYDLGRETGTSGGLQLLRAGHVLESTEPIVRAAIEEIKADRANEAERFLPYYRSMKERRHAAGTFADPGQGKDMLYGADEKPIQREWRPDSRRTRVWYGPIGSGDKLMRSNRRRDELRDMYGLIGLEMEAAGTMNRIRVGVIRGVCDYGDERKNKEWQPYAAAMAAAYAKAILREIPVVQNKTLAMDVPIEPGPAPAPQEPGQFVFNGPISGTNVQIGSSISGPTTFNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVR0</accession>
    <name>Q2GVR0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Life-span regulatory factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225600.1">
        <property type="nucleotide sequence ID" value="XM_001225599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVR0"/>
    <dbReference type="GeneID" id="4393519"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07944"/>
    <dbReference type="eggNOG" id="ENOG502S7ZU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1147083_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GVR0"/>
    <dbReference type="OMA" id="MASRCQT"/>
    <dbReference type="OrthoDB" id="2563506at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024368">
        <property type="entry name" value="Ecl1/2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12855">
        <property type="entry name" value="Ecl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="26501" checksum="4E8EA0F5F0AB7C68" modified="2006-03-21" version="1">MASRCQTPPIRSQMTRVVPRQGHVMLTPCKKKFFLHTPRQGPLLLVSDKRGLAQIAAFGPLQDQPHHTSHPGPRFTRALNTTSSSDNVDTINHQPPTTVMSFDWEHQFCLGCDKQTDGATYCSESCRLADYEKTSPSTPSSAASSPALSGPPPDWTLSRPTTTSNTKFYLSPAYDFGLAQPSTRRGSTQTLSPSASHTSLCSMRSNSSAGLDAAQLSEKAARELRAYARSFESVRLQRRRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVT7</accession>
    <name>Q2GVT7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_07917</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225573.1">
        <property type="nucleotide sequence ID" value="XM_001225572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVT7"/>
    <dbReference type="STRING" id="306901.Q2GVT7"/>
    <dbReference type="GeneID" id="4394480"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07917"/>
    <dbReference type="eggNOG" id="KOG0111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_27_1_1"/>
    <dbReference type="InParanoid" id="Q2GVT7"/>
    <dbReference type="OMA" id="YKPVWID"/>
    <dbReference type="OrthoDB" id="407442at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12347">
        <property type="entry name" value="RRM_PPIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034168">
        <property type="entry name" value="PPIE_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037">
        <property type="entry name" value="ATPASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="9"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="118"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ86664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="152" mass="16303" checksum="C4C8B4D08F2D1488" modified="2006-03-21" version="1">MADTSRWKSTVYVGGLAPAVTKTTLQEAFLPFGEIADVSLPKNENPSTAATEPHRGFAYVEFEDVEDAKEAIDNMDQAELFGRVIKVSAAKAPKSAGQVLGGKTAVWEQEGWLAENAVSEEDRLATDQAQNARPDDPMQGLEGLDVAGPKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVU3</accession>
    <name>Q2GVU3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_07911</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225567.1">
        <property type="nucleotide sequence ID" value="XM_001225566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVU3"/>
    <dbReference type="FunCoup" id="Q2GVU3">
        <property type="interactions" value="919"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GVU3"/>
    <dbReference type="GeneID" id="4394373"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07911"/>
    <dbReference type="eggNOG" id="KOG3418">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067359_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GVU3"/>
    <dbReference type="OMA" id="NQWFFTK"/>
    <dbReference type="OrthoDB" id="2365484at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.770:FF:000001">
        <property type="entry name" value="60S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018262">
        <property type="entry name" value="Ribosomal_eL27_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="Ribosomal_eL27_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01107">
        <property type="entry name" value="RIBOSOMAL_L27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ86658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="135" mass="15790" checksum="09109E1A9A54CF31" modified="2006-03-21" version="1">MKFLKTSRVCLVTRGRYAGKKVVIIQPVDSGNKSHPYGHALVAGIERYPSKITRRMSKTRQEKRSKVKPFIKVINYNHLMPTRYTLELEGLKAVLNAETFKEVSQREEAKKTVKKVLEERYTSGKNRWFFTPLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GW89</accession>
    <name>Q2GW89_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_07765</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225421.1">
        <property type="nucleotide sequence ID" value="XM_001225420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GW89"/>
    <dbReference type="FunCoup" id="Q2GW89">
        <property type="interactions" value="292"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GW89"/>
    <dbReference type="GeneID" id="4393118"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07765"/>
    <dbReference type="eggNOG" id="KOG1725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028431_2_1_1"/>
    <dbReference type="InParanoid" id="Q2GW89"/>
    <dbReference type="OMA" id="DTQYWVV"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ86512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="171" mass="19206" checksum="314E38F251B20C66" modified="2006-03-21" version="1">MSSPQDRVQNLVAQVDKELSKYPVLNNLEKQTSIPKAYGVLGLGALYLFLIIFNLGGQLLTNIAGFVIPGYFSLAALFTTSKADDTQWLTYWVVFAFFTVLESLVSVVYWFPFYYTFKFVFLLWLSLPAFSFRGAEIIFRSFLAPALGRYFHAPGSTASGLRAKADSLHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWD4</accession>
    <name>Q2GWD4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_07720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225376.1">
        <property type="nucleotide sequence ID" value="XM_001225375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWD4"/>
    <dbReference type="FunCoup" id="Q2GWD4">
        <property type="interactions" value="223"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GWD4"/>
    <dbReference type="GeneID" id="4393379"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07720"/>
    <dbReference type="eggNOG" id="KOG0425">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GWD4"/>
    <dbReference type="OMA" id="FQAHIKF"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010828">
        <property type="term" value="P:positive regulation of D-glucose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="9"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ86467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="237" mass="26663" checksum="224F2DB48549703C" modified="2006-03-21" version="1">MSRTAAPTGAKTRLMSEMKALRKETWIHFHDDDDQDSNILKWHFALMVINSDSPFNGGYFKAEMTFTDEYPYQPPKFRFLIPITHPNIYPDGQLCISILHKPGEDITSGEEASERWSPLQGAESVLRSVLLLLDDPEINSPANVDAGVMYRDRRGEYLEKATETAARSKKDVPADFEMPTSFVEAPPPKQDDDADFWAGSSDEEFDFGGSDTGDEDEMDFDDDEGEGEGSDEDEDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXB0</accession>
    <name>Q2GXB0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta-xylosidase C-terminal Concanavalin A-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_07394</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225050.1">
        <property type="nucleotide sequence ID" value="XM_001225049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXB0"/>
    <dbReference type="STRING" id="306901.Q2GXB0"/>
    <dbReference type="GeneID" id="4393978"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07394"/>
    <dbReference type="eggNOG" id="ENOG502SIVT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016508_3_0_1"/>
    <dbReference type="InParanoid" id="Q2GXB0"/>
    <dbReference type="OMA" id="ATHYNLG"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18833">
        <property type="entry name" value="GH43_PcXyl-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF17">
        <property type="entry name" value="BETA-XYLOSIDASE C-TERMINAL CONCANAVALIN A-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208706" description="Beta-xylosidase C-terminal Concanavalin A-like domain-containing protein" evidence="8">
        <location>
            <begin position="18"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="9">
        <location>
            <begin position="341"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="554"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="556"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ86141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="582" mass="63203" checksum="7510CAD29CB91E0A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXE1</accession>
    <name>Q2GXE1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_07363</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cerato-platanin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225019.1">
        <property type="nucleotide sequence ID" value="XM_001225018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXE1"/>
    <dbReference type="GeneID" id="4393561"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07363"/>
    <dbReference type="eggNOG" id="ENOG502SQTH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_762903_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GXE1"/>
    <dbReference type="OrthoDB" id="4898945at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22778">
        <property type="entry name" value="DPBB_CEPL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010829">
        <property type="entry name" value="Cerato-platanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07249">
        <property type="entry name" value="Cerato-platanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208708" evidence="5">
        <location>
            <begin position="19"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="211"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ86110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="363" mass="37421" checksum="51D0B91076BEC7A6" modified="2006-03-21" version="1">MQFSKILSIFSLAAATSAVTVSYDEGYDRADRSLTEVACSDGTNGLMWKYNWKVLGDVTGFPNIGGSDSIPGWNSPNCGTCWSVSYNGNTIHVVAVDHAGAGLNLGLNAFNKLTNNHGVELGLRSARNEAISASITVEYQWPSPSYAFHSVSIPTAAKHSDAAFPRVTGTLSSSIPCPRNTGVSNDCGRPAGGFPSNSSISLNTLTTFPSIATSSSSSSSSSSLSNGSNPPSPSPKTPLTPASKTNHPHIPQNPASAGPSHNSSATNPAAHPWLSPPSTTLCGPPTAAASARMSPWRCRTVSRRPGAQRHSSVVVLVVREGGKVEVPAVEPLVDDAAGVYGGAVNGGEPYDESVFALEGAEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXU6</accession>
    <name>Q2GXU6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_07208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224864.1">
        <property type="nucleotide sequence ID" value="XM_001224863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXU6"/>
    <dbReference type="GeneID" id="4393307"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07208"/>
    <dbReference type="HOGENOM" id="CLU_2922434_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GXU6"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ85955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="61" mass="6455" checksum="CBF6B63CC611CEA2" modified="2006-03-21" version="1">MGVDRCGALVEKDEQVCPGKAWCECAAISVANLGNASESQGVGLNLQGNFWLFSALVVLWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYE7</accession>
    <name>Q2GYE7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_07007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224663.1">
        <property type="nucleotide sequence ID" value="XM_001224662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYE7"/>
    <dbReference type="STRING" id="306901.Q2GYE7"/>
    <dbReference type="GeneID" id="4394261"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07007"/>
    <dbReference type="eggNOG" id="KOG1605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020262_7_0_1"/>
    <dbReference type="InParanoid" id="Q2GYE7"/>
    <dbReference type="OMA" id="YLFHEDN"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000089">
        <property type="entry name" value="NIF domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="328"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ85754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="533" mass="59186" checksum="0BD8982E4BA1C0DA" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYP6</accession>
    <name>Q2GYP6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_06908</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224564.1">
        <property type="nucleotide sequence ID" value="XM_001224563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYP6"/>
    <dbReference type="GeneID" id="4394229"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06908"/>
    <dbReference type="eggNOG" id="ENOG502SCR5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_689134_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYP6"/>
    <dbReference type="OMA" id="YPGMMWL"/>
    <dbReference type="OrthoDB" id="5588185at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ85655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="375" mass="40208" checksum="3F8F92ADB60B53C6" modified="2006-03-21" version="1">MDPSTSDSIRPATLSARPLSSRSVAEYRLPAATQTHEFARVPGSKFVLLSQMSDSELIKIELDPTSEEPIALQSFPIGESSASGLHGVWPSKKYPGMMWLTLQSENKLLLVEPGPDLSTAPSIIQTIDVPEPGNGPHCIFEIGNRVWSGLKVASRQTGEYYVFSADIDNAADRVLYPCLNSPVFIQEEPTTRLIYVTQDVASSIMRINVTSGETTQLPIPPDVGSTPVGMTTVSGPLMGLWFTLAGNAAGGSGSFGRIEPTGELQFFQLREPMLGANAGLLHIADASTIDSGPALWLLSSSLLSSNSADALIRVTFDQAVTAVAGEEYISMPTQNAQVHRVVTLDATVLVSELRTFTLAQLTYKNTVAGKWVPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZ71</accession>
    <name>Q2GZ71_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">High-affinity methionine permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_05175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224389.1">
        <property type="nucleotide sequence ID" value="XM_001224388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZ71"/>
    <dbReference type="STRING" id="306901.Q2GZ71"/>
    <dbReference type="GeneID" id="4392613"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05175"/>
    <dbReference type="eggNOG" id="KOG1287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013661_4_1_1"/>
    <dbReference type="InParanoid" id="Q2GZ71"/>
    <dbReference type="OMA" id="WIGCGLI"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000025">
        <property type="entry name" value="High-affinity methionine permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF382">
        <property type="entry name" value="LOW-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ88556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="57571" checksum="A416A198B130FDAE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZE5</accession>
    <name>Q2GZE5_CHAGB</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224315.1">
        <property type="nucleotide sequence ID" value="XM_001224314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZE5"/>
    <dbReference type="GeneID" id="4391617"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05101"/>
    <dbReference type="eggNOG" id="ENOG502RJ0P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1377974_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZE5"/>
    <dbReference type="OMA" id="LIVFFTH"/>
    <dbReference type="OrthoDB" id="4590319at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="198" mass="21481" checksum="30C0B5370C334F62" modified="2006-03-21" version="1">MLAVTRAVNILTRTIQARQTFTFTNPPFPPFRQPDDFDDDDDVNPFRLDPEDPSDDNNHKLSAGTIAAIVISIVVFFIVITGLIVFFTHRRRKARRDVEMSVIKEASVSATAVTASGALDPPPPYVESHPGSPHLAQERRESRSDGSQSGKEEDSDVMGSHATITDGLAPGRHTGLGPDHGAGIHAGPGTHDDDDRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZG1</accession>
    <name>Q2GZG1_CHAGB</name>
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        <recommendedName>
            <fullName evidence="4">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">CHGG_05085</name>
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    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224299.1">
        <property type="nucleotide sequence ID" value="XM_001224298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZG1"/>
    <dbReference type="STRING" id="306901.Q2GZG1"/>
    <dbReference type="GeneID" id="4392309"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05085"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_4_1_1"/>
    <dbReference type="InParanoid" id="Q2GZG1"/>
    <dbReference type="OMA" id="STYMVGE"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF100">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208775" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="140"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ88466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="643" mass="69407" checksum="13BBB87198F83190" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-05-01" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZQ4</accession>
    <name>ESF2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Pre-rRNA-processing protein ESF2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>18S rRNA factor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ESF2</name>
        <name type="ORF">CHGG_04992</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ESF2/ABP1 family.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAQ88373" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="frameshift">
            <sequence resource="EMBL-CDS" id="EAQ88373" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88373.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224206.1">
        <property type="nucleotide sequence ID" value="XM_001224205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZQ4"/>
    <dbReference type="FunCoup" id="Q2GZQ4">
        <property type="interactions" value="825"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GZQ4"/>
    <dbReference type="GeneID" id="4392017"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04992"/>
    <dbReference type="eggNOG" id="KOG3152">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054086_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GZQ4"/>
    <dbReference type="OrthoDB" id="287393at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12263">
        <property type="entry name" value="RRM_ABT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001147">
        <property type="entry name" value="Pre-rRNA-processing protein esf-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034353">
        <property type="entry name" value="ABT1/ESF2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000285368" description="Pre-rRNA-processing protein ESF2">
        <location>
            <begin position="1"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="121"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="269"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="332" mass="37197" checksum="57D01E7537799CD4" modified="2007-05-01" version="2">MSTDKRNQFLDAGDSEDDAGHGYDSEEDLQKGGRSAKRRRVDDDDSDAEDVSDQEEEHGEDGATNLREGTADSEAARDDEEIAEEGPKDDKADLPAELPGVSKPLAKKNLVASEAAIKKSGVVYLSRIPPFMKPAKLRSLLEPYGKINRIFLTPEDPTEHTRRVRNGGNKKRSFTEGWVEFVKKKDAKKVCDLLNAQTIGGKKSSWYHDDVWALKYLNGFKWHHLTEQISAENAERTSRIRAEVAKTTRENKEFVRNVERAKVINGIQSKAAAKRKKTDDSEEAAGSGEAVGKTEGESAQDKRRTFKQILLAKKRKHEEQPAHVLRVLSKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H067</accession>
    <name>Q2H067_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="8">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_04829</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eIF-5A family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224043.1">
        <property type="nucleotide sequence ID" value="XM_001224042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H067"/>
    <dbReference type="FunCoup" id="Q2H067">
        <property type="interactions" value="896"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H067"/>
    <dbReference type="GeneID" id="4393018"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04829"/>
    <dbReference type="eggNOG" id="KOG3271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102600_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H067"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0385">Hypusine</keyword>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor 5A-like N-terminal" evidence="9">
        <location>
            <begin position="19"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ88210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="158" mass="17116" checksum="308DC4DD280728D0" modified="2006-03-21" version="1">MSEEEHAFEQDAAGESGASLTYPMQCSALRKNGHVVIKGRPCKIVDMSTSKTGKHGHAKVHLVAIDIFTGKKLEDLSPSTHNMDVPNVKRTEMMSRSPRASWVNKSRKVSKPGRISVGLGSDQTLRNKQANTATPVITIVASMGEEAAISWKEDSAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0A2</accession>
    <name>Q2H0A2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="7">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_04794</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="7"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224008.1">
        <property type="nucleotide sequence ID" value="XM_001224007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0A2"/>
    <dbReference type="FunCoup" id="Q2H0A2">
        <property type="interactions" value="218"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H0A2"/>
    <dbReference type="GeneID" id="4392434"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04794"/>
    <dbReference type="eggNOG" id="KOG2381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009049_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H0A2"/>
    <dbReference type="OMA" id="NWMVKVD"/>
    <dbReference type="OrthoDB" id="3349449at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="166"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="322"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="656"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="608"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="687"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ88175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="826" mass="92004" checksum="DA73B2A9B8C98742" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0K2</accession>
    <name>Q2H0K2_CHAGB</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_04694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0K2"/>
    <dbReference type="STRING" id="306901.Q2H0K2"/>
    <dbReference type="GeneID" id="4391637"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04694"/>
    <dbReference type="eggNOG" id="ENOG502T60I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_915272_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H0K2"/>
    <dbReference type="OrthoDB" id="5220781at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ88075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="304" mass="33256" checksum="47CA4A9FF875A309" modified="2006-03-21" version="1">MFFYFVDQARQLANTLASVANPGAPAQTECMVEEAEPSHKQRALLLGLAQAKGFVSMVASEAAISDPPAVGSNVNWQFATRGMDLVLVSSHEFASRGDADPDIQFERSTYINGAQNILRGIPRNLTPDESAMLRRALPRSLAPPDTGPASWWRRLNGQPQDAAPAAGGAGGRDQQNMVQSLLAIVLYCMYVLAMRFENLGIRMLAAERQHAYASRLLLATFDLACLAVRMLRVCSEFWPCQILFEMLKYFAIGVLGAFVEVWERVVVEEAARGDAITEDEAEENDEPVLLLSANLPQPSKTVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0L8</accession>
    <name>Q2H0L8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223892.1">
        <property type="nucleotide sequence ID" value="XM_001223891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0L8"/>
    <dbReference type="STRING" id="306901.Q2H0L8"/>
    <dbReference type="GeneID" id="4392891"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04678"/>
    <dbReference type="eggNOG" id="ENOG502RZ04">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062257_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H0L8"/>
    <dbReference type="OMA" id="HYTEDHE"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="255" mass="28765" checksum="90F6B89D3B58C385" modified="2006-03-21" version="1">MATEKRPNVKDVEDLQIFCLFDSTTGHYVEWFHYTEDHEAYHGSSYKDRRDMTLDEFATGLKRLSDDAIFPEVPTDQQITIAPKNLDGSTIHIKRPGLKYYLGAEKEAECATKDQELAEVFTTESISKTPHPYLVRYHGCTVRRGRITGIAMERLGETLSHYARCPGGCISEHKTMFDQIDKQAFLAGVESAVKFLHSLGLAHNDINPRNIMVREARKCLNPGFFTLFFDGHPSCGLSCHGGARERTLMETTACP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0V1</accession>
    <name>Q2H0V1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_04595</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223809.1">
        <property type="nucleotide sequence ID" value="XM_001223808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0V1"/>
    <dbReference type="GeneID" id="4392748"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04595"/>
    <dbReference type="eggNOG" id="ENOG502SHZM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008599_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H0V1"/>
    <dbReference type="OMA" id="LQTMPEE"/>
    <dbReference type="OrthoDB" id="3362851at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="359"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ87976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="797" mass="87845" checksum="D4AEEB58C5E0E074" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-25" modified="2025-06-18" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0X9</accession>
    <name>MCD4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber>2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">MCD4</name>
        <name type="ORF">CHGG_04567</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text>Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000246205" description="GPI ethanolamine phosphate transferase 1">
        <location>
            <begin position="1"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="679"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="752"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="795"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="825"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="862"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="715"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="921" mass="101802" checksum="285252B2C2D957E8" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H340</accession>
    <name>Q2H340_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ87187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223020.1">
        <property type="nucleotide sequence ID" value="XM_001223019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H340"/>
    <dbReference type="FunCoup" id="Q2H340">
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    </dbReference>
    <dbReference type="STRING" id="306901.Q2H340"/>
    <dbReference type="GeneID" id="4392835"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03806"/>
    <dbReference type="eggNOG" id="KOG1938">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014185_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H340"/>
    <dbReference type="OMA" id="PHMENRV"/>
    <dbReference type="OrthoDB" id="203724at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="791"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="829" mass="89092" checksum="8E47B745B8569DB2" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3U9</accession>
    <name>Q2H3U9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
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    </dbReference>
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    <dbReference type="AlphaFoldDB" id="Q2H3U9"/>
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    <dbReference type="OrthoDB" id="4590900at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="219" mass="25091" checksum="29726AD5F6D27B69" modified="2006-03-21" version="1">MTYNPYRQPPHDALYGSQYRSWSRDRGRDHYRPREADPRVGTPRASRNTRRGSPPRGADYPGASRIDDDDGYYERLGRRLGRDRYAGVGGPTYGEFDDRFRQAGAELNRERREAAVNYHYDLPRAMPPPRGGGGFDGYVPGYDYPPDPQTMPRAGNPPPTQPYHPHPPRDRSRSVPRRGGERLRKTRSKPKLSFWYVYVGTTDPDGKVIDGYEGYESEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H435</accession>
    <name>Q2H435_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CHGG_06580</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222675.1">
        <property type="nucleotide sequence ID" value="XM_001222674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H435"/>
    <dbReference type="STRING" id="306901.Q2H435"/>
    <dbReference type="GeneID" id="4391097"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06580"/>
    <dbReference type="eggNOG" id="KOG4628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007230_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H435"/>
    <dbReference type="OMA" id="SGNIDWV"/>
    <dbReference type="OrthoDB" id="5357315at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Protease-associated PA domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="PA_dom_sf"/>
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        <property type="entry name" value="Znf_RING"/>
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    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
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        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="TARGET OF ERK KINASE MPK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PA"/>
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        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
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    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208929" description="RING-type E3 ubiquitin transferase" evidence="15">
        <location>
            <begin position="28"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="721"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="301"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="371"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="633"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="774"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="841"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
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        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="509"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="638"/>
            <end position="651"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="652"/>
            <end position="661"/>
        </location>
    </feature>
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        <location>
            <begin position="783"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="841"/>
            <end position="853"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00022771"/>
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            <dbReference type="ARBA" id="ARBA00022786"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ89961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="861" mass="92756" checksum="C751CCC95F39B87F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4H3</accession>
    <name>Q2H4H3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_06442</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probably involved in the biogenesis of the COX complex.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF2">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 1"/>
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    </dbReference>
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        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
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        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ89823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="292" mass="33287" checksum="11E9CC394C96265E" modified="2006-03-21" version="1">MAANRASARILHSLRTQSRPIGKTSPRWPQPNSSTTRLPPRRPISSTPRRPKQAADDPGFTSIVDNPPELVRAGRKHGPGLIILAIIPITAFLLGTWQVKRLEWKTDLIAKCEDRIVRQPLPLPPRVDPSAIAEFDFRRVYVTGRFRHDQEMLVGSRMRDGEQGYIVVTPLEREGDDGAKVLVNRGWISKANAEQSKRPAGLPQGEVRVEGMLRQPWKKNMFTPVNRPDKREFYFPDVQQMAALTGSQAVWIEQTMEPDYFQFLDYHARGVPIGRPAEVNLRNNHAQYIFTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4Z3</accession>
    <name>Q2H4Z3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_06272</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222367.1">
        <property type="nucleotide sequence ID" value="XM_001222366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4Z3"/>
    <dbReference type="FunCoup" id="Q2H4Z3">
        <property type="interactions" value="964"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H4Z3"/>
    <dbReference type="GeneID" id="4391321"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06272"/>
    <dbReference type="eggNOG" id="KOG3421">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082438_3_0_1"/>
    <dbReference type="InParanoid" id="Q2H4Z3"/>
    <dbReference type="OMA" id="KLCFVVD"/>
    <dbReference type="OrthoDB" id="1875589at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL14" evidence="4">
        <location>
            <begin position="53"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ89653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="142" mass="16049" checksum="2061714F1F75AC52" modified="2006-03-21" version="1">MASIDIEATSWRRVEVGRVLKLESGSLATIVEIIDHKRALVDGPSTNEKLATPRGIVQLSRTLLTPIVVEKLPRGARSAAVKKAWEAAGVDSKWSESNWAKKQLQQERRQSLTDFDRFKVMRLKKQRRFEERKALAKIKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5B4</accession>
    <name>Q2H5B4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_06151</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="4"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222246.1">
        <property type="nucleotide sequence ID" value="XM_001222245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5B4"/>
    <dbReference type="STRING" id="306901.Q2H5B4"/>
    <dbReference type="GeneID" id="4390639"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06151"/>
    <dbReference type="eggNOG" id="KOG2277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002806_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5B4"/>
    <dbReference type="OMA" id="EACEQYV"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF113">
        <property type="entry name" value="POLY(A) RNA POLYMERASE CID11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="10">
        <location>
            <begin position="125"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="10">
        <location>
            <begin position="186"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="9">
        <location>
            <begin position="322"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="439"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="618"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="685"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="841"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="957"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="453"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="623"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="711"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="848"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="881"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1002"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1043"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1086"/>
            <end position="1097"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ89532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1097" mass="120029" checksum="6458BF25736D1A76" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5U2</accession>
    <name>Q2H5U2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_05973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222068.1">
        <property type="nucleotide sequence ID" value="XM_001222067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5U2"/>
    <dbReference type="GeneID" id="4391381"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05973"/>
    <dbReference type="HOGENOM" id="CLU_1786621_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5U2"/>
    <dbReference type="OrthoDB" id="10469438at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="145" mass="16330" checksum="9AE49BCE38F861DD" modified="2006-03-21" version="1">MAKYLAHRRRKEELLGQSVDSVAAAGFSVEDIVPPSRACPGRIHEIRDNMGWHGINTNHRGQMNPCIGITQRVAMAERMWKRQTTGYCTICQTNGPQTRNLAAEKFHRQIPASSMPYSYGPHTALWARHEHAKNQSIGSHDPSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H648</accession>
    <name>Q2H648_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221962.1">
        <property type="nucleotide sequence ID" value="XM_001221961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H648"/>
    <dbReference type="GeneID" id="4391022"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05867"/>
    <dbReference type="eggNOG" id="ENOG502RW1Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_501519_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H648"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="543" mass="61358" checksum="11B23802041C5E4E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6C6</accession>
    <name>Q2H6C6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221884.1">
        <property type="nucleotide sequence ID" value="XM_001221883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6C6"/>
    <dbReference type="STRING" id="306901.Q2H6C6"/>
    <dbReference type="GeneID" id="4390171"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05789"/>
    <dbReference type="eggNOG" id="ENOG502SANN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016815_4_0_1"/>
    <dbReference type="InParanoid" id="Q2H6C6"/>
    <dbReference type="OMA" id="CVDVESY"/>
    <dbReference type="OrthoDB" id="5953249at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="2">
        <location>
            <begin position="338"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="596" mass="67191" checksum="16CB27AC032C345D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6D8</accession>
    <name>Q2H6D8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein BNI4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221872.1">
        <property type="nucleotide sequence ID" value="XM_001221871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6D8"/>
    <dbReference type="STRING" id="306901.Q2H6D8"/>
    <dbReference type="GeneID" id="4390013"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05777"/>
    <dbReference type="eggNOG" id="KOG4339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011525_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6D8"/>
    <dbReference type="OMA" id="EINNFKM"/>
    <dbReference type="OrthoDB" id="5563016at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF18">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="775" mass="81667" checksum="0439094F0E147F6E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6E9</accession>
    <name>Q2H6E9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_05766</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221861.1">
        <property type="nucleotide sequence ID" value="XM_001221860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6E9"/>
    <dbReference type="GeneID" id="4390798"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05766"/>
    <dbReference type="eggNOG" id="KOG2262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004965_5_0_1"/>
    <dbReference type="InParanoid" id="Q2H6E9"/>
    <dbReference type="OMA" id="WGNSAVD"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208995" evidence="10">
        <location>
            <begin position="18"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ89147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="297" mass="33148" checksum="E870285FD3537780" modified="2006-03-21" version="1">MTWWAFLLAVFISFVFSLPIGIIQAVTNNQIGLNVLTEFIYGYIQPGRPLALMIFKTFGYITMSQALTFVSDLKFGHYMKIPPRTMFMAQVVATTFSCFVQVVVLNYALKNIPGVCEPTQPDHFTCPGGRVFFSASVIWGLIGPARIFSPGQIYSSLFLFFILGAVTPLVIYLLARRRPKSFLRYLMAPVIFGGAGAIPPATPLNYLSWGIVGFVFQFLIKKRHFAWWSRLNFLTSSGLDLGLALSTLVIFFAFTLREVEPPQWWGNEVVKSTMDYRGDAVQVVLGAGETFGPASWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6G6</accession>
    <name>Q2H6G6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_05749</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221844.1">
        <property type="nucleotide sequence ID" value="XM_001221843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6G6"/>
    <dbReference type="FunCoup" id="Q2H6G6">
        <property type="interactions" value="601"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H6G6"/>
    <dbReference type="GeneID" id="4391310"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05749"/>
    <dbReference type="eggNOG" id="KOG3405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112527_0_2_1"/>
    <dbReference type="InParanoid" id="Q2H6G6"/>
    <dbReference type="OMA" id="ADYWDPE"/>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.10:FF:000009">
        <property type="entry name" value="DNA-directed RNA polymerases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00192">
        <property type="entry name" value="RNApol_arch_Rpo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ89130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18047" checksum="797A69476E5958DB" modified="2006-03-21" version="1">MSDYSGGDDDREPLNDEPAFDEDPDEYYEPEPEPAEEDDAARAPELEGENQDADHVVASGDPNAAANHGKGNDKSHKDKKIPNDQRTTTPFMTKYEKARILGTRALQISMNAPVLVDLEGETDPLQIAIKELREKKIPLIVRRYLPDGYYEDWSCEELLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6Y4</accession>
    <name>Q2H6Y4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRP9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221676.1">
        <property type="nucleotide sequence ID" value="XM_001221675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6Y4"/>
    <dbReference type="STRING" id="306901.Q2H6Y4"/>
    <dbReference type="GeneID" id="4390536"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05581"/>
    <dbReference type="eggNOG" id="ENOG502SRXX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096859_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6Y4"/>
    <dbReference type="OMA" id="YETNKGA"/>
    <dbReference type="OrthoDB" id="5419752at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039914">
        <property type="entry name" value="SRP9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039432">
        <property type="entry name" value="SRP9_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834:SF12">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05486">
        <property type="entry name" value="SRP9-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP9" evidence="2">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="194" mass="20047" checksum="3C93DA1A125AC6BF" modified="2006-03-21" version="1">MPYYAKSEDWLHQSSLLLQARPLTTRITTRYHLKPARRVPKPKKSTDADATTTTTPPAAPKNQQQQQQAETDAKPPRGHLVLKTYDAHSGVTLKYKTSKAAEVTRLVQMLGTLGRGMAGLAATTTAAVENVAGAGAGAGGEDEVMVDVSGVSGGGEVGSGAQTPVGGATAGGKEQQQQQQGGGGGGKKKKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6Z8</accession>
    <name>Q2H6Z8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_05567</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221662.1">
        <property type="nucleotide sequence ID" value="XM_001221661.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H6Z8"/>
    <dbReference type="GeneID" id="4389959"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05567"/>
    <dbReference type="eggNOG" id="KOG0401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003998_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6Z8"/>
    <dbReference type="OMA" id="PRGGPNM"/>
    <dbReference type="OrthoDB" id="514777at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000020">
        <property type="entry name" value="Eukaryotic translation initiation factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.970.30:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor subunit eIF-4F, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.30">
        <property type="entry name" value="eIF4G, eIF4E-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022745">
        <property type="entry name" value="eIF4G1_eIF4E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036211">
        <property type="entry name" value="eIF4G_eIF4E-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
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        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
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    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="27"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="217"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ88834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="292" mass="32244" checksum="1F820AA0D9BFD72F" modified="2006-03-21" version="1">MSSLKITSAFKLPSGYELPRLGFGVYQTPVEDTARCVTEAFQAGYRHIDSAAGYRNEGPCGEAIRAASSIPRESIFFTSKVPPQKMGYEGTKSQIAESLAESGLEYIDLMLIHAPYGGSANRKGSWKALVEAVEAGKLRSIGVSNYGVQHLDELEKHIAELEKERGGKGKGGVISVGQWEIHPYLPRNDIVEWCAKRGIAVEAYCPLVQGKRWGEPAVKKAAEKYGKSEAQILIRWSLDKGLIPLPKSVTSQRIRDNADVFDFELTPEEVKEIETDEYTVIAWDPTVIPLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8C2</accession>
    <name>Q2H8C2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_03532</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230048.1">
        <property type="nucleotide sequence ID" value="XM_001230047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8C2"/>
    <dbReference type="STRING" id="306901.Q2H8C2"/>
    <dbReference type="GeneID" id="4388525"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03532"/>
    <dbReference type="eggNOG" id="ENOG502SKH5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_8_4_1"/>
    <dbReference type="InParanoid" id="Q2H8C2"/>
    <dbReference type="OMA" id="VEPFVRM"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF30">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="3"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ91597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="308" mass="33649" checksum="3BDB47EB5F50100B" modified="2006-03-21" version="1">MATHTVFVCGATGAQGGALARQLRALNWEVRTITRNTNSAAAQSLASIGVKVHEGSWSDRVALEAAISGCDLLFLNLLPDLTNFTAELEDGTTVLAVAKAAGIQHVVYSTSIPLPEDKTDPNSFAAQLFQPKKQLEQAIQTAGFPRWTILRPGAFMSNYLPPMVNLQYPGATETGVFTMALLATTMLPMIDTEDIGKFAVAAFQHPDRFHAQVVLVVSESLSVEEGLETMRRVLGRPNIRGKYLDGKELQAAKATNPILGMQELLRHVDVFEGADAREAAKKWGVETGTFEEFVKREKKVFDEAYRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8N0</accession>
    <name>Q2H8N0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">GPI inositol-deacylase</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_03424</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229940.1">
        <property type="nucleotide sequence ID" value="XM_001229939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8N0"/>
    <dbReference type="GeneID" id="4389619"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03424"/>
    <dbReference type="eggNOG" id="KOG2029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_182_1_1"/>
    <dbReference type="InParanoid" id="Q2H8N0"/>
    <dbReference type="OMA" id="PLDANHH"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="9">
        <location>
            <begin position="25"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ91489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="275" mass="30334" checksum="AA8CE94F6FA1CC0D" modified="2006-03-21" version="1">MSTTQEVGSRGELHELYIPPSGTPKQIDIVAVHGLNGDFRNTWTHIPLAGKGPQTLWLQDLLPGKLPNAHVMSFQYDSSTHGMSQQSVRGNAGKLVRLLRDIREDYEDEDRPIVFIGHSLGGIVIKQALKHAKDFHFTDISTHTHGIVFFGTPHRGADAAGWASTLSGILATATHKPPSKFLEALKNDSVELRKISEDFRPLCGGFNIVSFYEEHAHRVLGRVVVDKSSAIMGLPNEDPMMLGGSHSTMCKFGVGDKRFDPVWRAIRRAAKPRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8T8</accession>
    <name>Q2H8T8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_03366</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229882.1">
        <property type="nucleotide sequence ID" value="XM_001229881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8T8"/>
    <dbReference type="FunCoup" id="Q2H8T8">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H8T8"/>
    <dbReference type="GeneID" id="4388518"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03366"/>
    <dbReference type="eggNOG" id="KOG1396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006633_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H8T8"/>
    <dbReference type="OMA" id="EFFCPVS"/>
    <dbReference type="OrthoDB" id="266334at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000082">
        <property type="entry name" value="Sad1/UNC domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208645" description="SUN domain-containing protein" evidence="6">
        <location>
            <begin position="28"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="7">
        <location>
            <begin position="200"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="372"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="444"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="735"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="487"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="525"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="743"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="754"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="824"/>
            <end position="836"/>
        </location>
    </feature>
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        <location>
            <begin position="837"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="904"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ91431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="945" mass="103576" checksum="208351E4C234DF0E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H928</accession>
    <name>Q2H928_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_03276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001229791.1"/>
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    <dbReference type="AlphaFoldDB" id="Q2H928"/>
    <dbReference type="STRING" id="306901.Q2H928"/>
    <dbReference type="GeneID" id="4389316"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03276"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_038526_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H928"/>
    <dbReference type="OMA" id="DGVFCFW"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="24"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="112"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="257"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ91341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="38154" checksum="94D65F4E1E026329" modified="2006-03-21" version="1">MVYGKKTTTISAANSQQDKEYVFPKGPEDTVSALRWSPVSNHLAAASWDGKVYIYDATNTTSSDTIKGVAAIPVGSPVLDCDFNKDGTIAVGASADKKLHLMDLNSSQTMTLEAHTSPVRTVRFVNVPSANAPIIASGSWDRTVRYWDMRQPQPIGALELPERVYAMDTGGSVLAIGTAENHLHLVNLHDNPLKLWKSIASPIPHQTTAVSVTPDGTRWAIGTIAGRAAAQVVDEKDLSLANLSFKCHREAVPNKRNATDSYAVNDVAWSPGHKDVFATAGSDGTFSIWDVLNRNRLRSFPKVSSPVTAVSFTRDGMGMAYAMGYDWAKGYQHHKAGAETKIVMHRFATALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9E4</accession>
    <name>Q2H9E4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CHGG_03160</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + AH2 + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + A + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the MoaC family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229676.1">
        <property type="nucleotide sequence ID" value="XM_001229675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9E4"/>
    <dbReference type="STRING" id="306901.Q2H9E4"/>
    <dbReference type="GeneID" id="4388490"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03160"/>
    <dbReference type="eggNOG" id="KOG2876">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_7_2_1"/>
    <dbReference type="InParanoid" id="Q2H9E4"/>
    <dbReference type="OMA" id="QTVHMTS"/>
    <dbReference type="OrthoDB" id="429626at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21117">
        <property type="entry name" value="Twitch_MoaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="entry name" value="Molybdopterin cofactor biosynthesis C (MoaC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01224_B">
        <property type="entry name" value="MoaC_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040064">
        <property type="entry name" value="MoaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
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    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="MoaA_twitch"/>
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    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="MoaC"/>
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    <dbReference type="InterPro" id="IPR047594">
        <property type="entry name" value="MoaC_bact/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
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    <dbReference type="InterPro" id="IPR050105">
        <property type="entry name" value="MoCo_biosynth_MoaA/MoaC"/>
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    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
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    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
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    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
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    <dbReference type="NCBIfam" id="NF006870">
        <property type="entry name" value="PRK09364.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960:SF0">
        <property type="entry name" value="MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01383">
        <property type="entry name" value="cyclic_pyranopterin_phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01386">
        <property type="entry name" value="main_SPASM_domain-containing"/>
        <property type="match status" value="1"/>
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    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="Molybdenum cofactor biosynthesis protein C, MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="88"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="467"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008484"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009862"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAQ91225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="677" mass="73877" checksum="AC030F9A076C887D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-12-16" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9P7</accession>
    <name>KYNU1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Kynureninase 1</fullName>
            <ecNumber evidence="1">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Biosynthesis of nicotinic acid protein 5-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">L-kynurenine hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BNA5-1</name>
        <name type="ORF">CHGG_03057</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-kynurenine + H2O = anthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the kynureninase family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="1"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229573.1">
        <property type="nucleotide sequence ID" value="XM_001229572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9P7"/>
    <dbReference type="SMR" id="Q2H9P7"/>
    <dbReference type="FunCoup" id="Q2H9P7">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H9P7"/>
    <dbReference type="GeneID" id="4389081"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03057"/>
    <dbReference type="eggNOG" id="KOG3846">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_4_0_1"/>
    <dbReference type="InParanoid" id="Q2H9P7"/>
    <dbReference type="OMA" id="LPGWNSH"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00329"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000031">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084:SF0">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22580">
        <property type="entry name" value="KYNU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000356974" description="Kynureninase 1">
        <location>
            <begin position="1"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="183"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03017"/>
        </source>
    </evidence>
    <sequence length="509" mass="55240" checksum="B95634E76F9ED0D2" modified="2006-03-21" version="1">MSEILKSPIQSPLLRGFVTSRRCDASEIEDLGSNVTKGLRVAGGRRVLRSHFFSYCLTYPAVNVAATTETGSGDGATEKCVYLCGNSLGLQPKRTQTRVNQYLSTWGTQGVQGHFKPLEESPLPTWLDADDRAAQLIAPIVGASKAEVAVMQTLTANLHLLMSAFYKPDINGKHKIILESKAFPSDHFAVETQLRHHNLDPATSMITLTSPSSPEDNILTTAEILSAITTHAATTALILLPGIQYYTGQLLDIPTITAHARTHSVFLIWDLAHAVGNAPLHLHDWGVDAAAWCSYKYLNGGPGCIGGLFVHERNSAVPPPVGELEVQQKEGEWEREGYANRLAGWWGNDKRTRFAMVNRFRPVPGAAGFQLSNPSILDITSLTASLEVFAEAGGVGALRGKSLRLTAFLEELLVGEGSSIVGVEERALFRVITPSDPGQRGAQLSLMLRGGLLEAVMRELEKRAVIVDERKPDVIRVAPAPLYNSFEDCVRFVVAFGEALAVARKEVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAC4</accession>
    <name>Q2HAC4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear protein localization protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_02830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NPL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229346.1">
        <property type="nucleotide sequence ID" value="XM_001229345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAC4"/>
    <dbReference type="FunCoup" id="Q2HAC4">
        <property type="interactions" value="858"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HAC4"/>
    <dbReference type="GeneID" id="4388854"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02830"/>
    <dbReference type="eggNOG" id="KOG2834">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017172_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HAC4"/>
    <dbReference type="OMA" id="TKDRYVP"/>
    <dbReference type="OrthoDB" id="10251089at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08061">
        <property type="entry name" value="MPN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016563">
        <property type="entry name" value="Npl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007717">
        <property type="entry name" value="NPL4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007716">
        <property type="entry name" value="NPL4_Zn-bd_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710:SF0">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05021">
        <property type="entry name" value="NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05020">
        <property type="entry name" value="zf-NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010052">
        <property type="entry name" value="Polyub_prc_Npl4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MPN" evidence="9">
        <location>
            <begin position="228"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="53"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="564"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ90895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="616" mass="69230" checksum="78C31121269E4F9D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAW8</accession>
    <name>Q2HAW8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_02636</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229152.1">
        <property type="nucleotide sequence ID" value="XM_001229151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAW8"/>
    <dbReference type="STRING" id="306901.Q2HAW8"/>
    <dbReference type="GeneID" id="4389625"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02636"/>
    <dbReference type="eggNOG" id="ENOG502SSVT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031222_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HAW8"/>
    <dbReference type="OMA" id="QYNSPVS"/>
    <dbReference type="OrthoDB" id="5239590at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209101" evidence="3">
        <location>
            <begin position="21"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ90701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="507" mass="54134" checksum="02D414E1609AF33A" modified="2006-03-21" version="1">MPLRAACLLAAAVCARLAATLFVAPDSPCSKYCGNVQGSTATDEMACDAGTLRNSPTGVVWEQCIGCLLTSTHVAGGQSDLQALLYNLRFSMGHCLFGGGTNPCLTSTACEPFKAAVVYQNMTTSVPPLEYCKKWDPGMVDHCSTCLVPLLQDDVEGISQNNYMTTLEAACEQMPEPGSTVSIDGDLFGPDPITIVAPEVSYVGVPSPDYGPVSLGARVGIAFGGLALILAIVGFCIIFNGKRKRRAFLRELERRHGGQGWPHPKTRYGGGEGQDMFETPVSQQPLRGWENGSPVSAHTETQFPRYFSPYSSQYNSPVTGPDGSGPSHAQWPTIASHLPTQEQLDQIIQAQSPTHSSPPPAFTQWPTISQEKMAMQMHSQPEKRQDEIPIGVALGGDEASLRSKASNLNLNGYPIESKGKGRDEAYEMHEVESPYANGNGDAAGRQYEYPYRMPAEPQAPVLHHPGYGRHHGSRPGSGGAGGVDASAGYGMGEYGAGQYAQRGFTAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-09-29" modified="2025-04-09" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBN3</accession>
    <name>CGHD_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor cghD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Sch210972 biosynthesis cluster protein D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cghD</name>
        <name type="ORF">CHGG_02371</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2015" name="ChemBioChem" volume="16" first="2294" last="2298">
            <title>Involvement of lipocalin-like CghA in decalin-forming stereoselective intramolecular [4+2] cycloaddition.</title>
            <authorList>
                <person name="Sato M."/>
                <person name="Yagishita F."/>
                <person name="Mino T."/>
                <person name="Uchiyama N."/>
                <person name="Patel A."/>
                <person name="Chooi Y.H."/>
                <person name="Goda Y."/>
                <person name="Xu W."/>
                <person name="Noguchi H."/>
                <person name="Yamamoto T."/>
                <person name="Hotta K."/>
                <person name="Houk K.N."/>
                <person name="Tang Y."/>
                <person name="Watanabe K."/>
            </authorList>
            <dbReference type="PubMed" id="26360642"/>
            <dbReference type="DOI" id="10.1002/cbic.201500386"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of the tetramic acid Sch210972, a potential anti-HIV fungal natural product that contains a decalin core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228887.1">
        <property type="nucleotide sequence ID" value="XM_001228886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBN3"/>
    <dbReference type="GeneID" id="4388356"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02371"/>
    <dbReference type="eggNOG" id="ENOG502S7PT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_578946_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HBN3"/>
    <dbReference type="OMA" id="DATAPCQ"/>
    <dbReference type="OrthoDB" id="4222821at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000453349" description="Transcription factor cghD">
        <location>
            <begin position="1"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Zn(2)-C6 fungal-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="26360642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="26360642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ90436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="484" mass="50375" checksum="E0663CCC25AD3C41" modified="2006-03-21" version="1">MFQTESHPAGGSPLQSIRSSCDRCRLQKLKCTVQSMESDGRMVCERCVRAKVPCAFGRRRRASRPSDTKKQGDSSTRRSTAPRTTNPEPTVLTPPLSTTSSTSEQTLGGATPSPTLATSSALEAPLETLAECEPDTTAPTYSYHHHHHDSYQLGEGPPTPFPNPATTGGGSGSSMMDWDWLEQDFHANELYCLDPELLASAPASTSTSTGSPTAHHRALPDGGSGSSTMSMGGGADTPFSTTASVAGRRLPALIAEMQQRLEALENGAWLHDGAQSFDHYPIGAVLRLSQEFGALAGQVLGMAATYGGGGGVPPSDVAGLQMMAAVGGGGGLYELGRGGLAEGGSSTATVLLVLGGYVFLVRLYGLVLGHFHAHLNRIPSGSLGGHMHSTPAPTTSPTLQLGELPSGGAMPDVSRIHAALGMLLAALHSVEEQLGQGGEVAREMVVSILTQGSGLEPAKLQDGFGDLGEKVRSVKELLREKMGL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-09-29" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBN4</accession>
    <name>CGHC_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trans-enoyl reductase cghC</fullName>
            <shortName evidence="4">ER cghC</shortName>
            <ecNumber evidence="3">1.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Sch210972 biosynthesis cluster protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cghC</name>
        <name type="ORF">CHGG_02370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2015" name="ChemBioChem" volume="16" first="2294" last="2298">
            <title>Involvement of lipocalin-like CghA in decalin-forming stereoselective intramolecular [4+2] cycloaddition.</title>
            <authorList>
                <person name="Sato M."/>
                <person name="Yagishita F."/>
                <person name="Mino T."/>
                <person name="Uchiyama N."/>
                <person name="Patel A."/>
                <person name="Chooi Y.H."/>
                <person name="Goda Y."/>
                <person name="Xu W."/>
                <person name="Noguchi H."/>
                <person name="Yamamoto T."/>
                <person name="Hotta K."/>
                <person name="Houk K.N."/>
                <person name="Tang Y."/>
                <person name="Watanabe K."/>
            </authorList>
            <dbReference type="PubMed" id="26360642"/>
            <dbReference type="DOI" id="10.1002/cbic.201500386"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Trans-enoyl reductase; part of the gene cluster that mediates the biosynthesis of the tetramic acid Sch210972, a potential anti-HIV fungal natural product that contains a decalin core (PubMed:26360642). The PKS module of cghG together with the enoylreductase cghC catalyze the formation of the polyketide unit which is then conjugated to 4-hydroxyl-4-methyl glutamate (HMG) by the condensation domain of the cghG NRPS module (PubMed:26360642). One unique structural feature of Sch210972 is the tetramic acid motif proposed to be derived from the non-proteinogenic amino acid HMG, by a Dieckmann-type condensation catalyzed by the reductase domain of cghG (PubMed:26360642). The aldolase cghB catalyzes the aldol condensation of 2 molecules of pyruvic acid to yield the intermediate 4-hydroxyl-4-methyl-2-oxoglutarate (HMOG), which can then be stereoselectively transaminated by an unidentified enzyme to form HMG (PubMed:26360642). The Diels-Alderase cghA then uses the Dieckmann product released by cghG as substrate and catalyzes the Diels-Alder cycloaddition to form the decalin ring of Sch210972 (PubMed:26360642). CghA also suppresses the nonenzymatic formation of the alternative stereoisomer (PubMed:26360642).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(2S,4S)-4-hydroxy-4-methylglutamate + 8 malonyl-CoA + 3 S-adenosyl-L-methionine + ATP + 8 NADPH + 11 H(+) = (2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 3 S-adenosyl-L-homocysteine + 8 CO2 + diphosphate + 8 NADP(+) + 8 CoA + 6 H2O</text>
            <dbReference type="Rhea" id="RHEA:67264"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167901"/>
            <dbReference type="ChEBI" id="CHEBI:167907"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:67265"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228886.1">
        <property type="nucleotide sequence ID" value="XM_001228885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBN4"/>
    <dbReference type="SMR" id="Q2HBN4"/>
    <dbReference type="GeneID" id="4388355"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02370"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_1_1"/>
    <dbReference type="InParanoid" id="Q2HBN4"/>
    <dbReference type="OMA" id="KGSIDIC"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000453335" description="Trans-enoyl reductase cghC">
        <location>
            <begin position="1"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="48"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="135"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="188"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="211"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="276"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="297"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="366"/>
            <end position="367"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q9Y7D0"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="26360642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="26360642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ90435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="375" mass="39772" checksum="82675B8CB12DAE76" modified="2006-03-21" version="1">MAISATTQSALVGGSQDDIILSTSAPIPQRLEDDQVAVAVKAIALNPVDTKMLGDFHTPGAVLGCEFSGVITSAGPVATSEWGLREGDRVSGAIMGMNPLRPQIGAFAQHTVAPAHVVLKVREDWDFAQGAGMGNAWYTSGWALFHTMGLPAGPQLEPLHTLVPPPPGNAGKLPSTNKPITVLVSGGSSSTGTTAVQLLKLAGYHVIATCSARNFDLARQYGADEVFDHSSPTCAADIRERTRNALRFALDCITTPETTRLCYAALGRSGGRYVSLDPFSEAVAATRGVVRPDWVLGPELVGEDIAWPEPHGRKGNPKARVFCEAWTRTLQRLVDQGLVKTHPQLVRDTGLKGALGGLDDIRAKKVSGQKLVYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBQ6</accession>
    <name>Q2HBQ6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar RNA-associated protein 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_02348</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228864.1">
        <property type="nucleotide sequence ID" value="XM_001228863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBQ6"/>
    <dbReference type="FunCoup" id="Q2HBQ6">
        <property type="interactions" value="263"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HBQ6"/>
    <dbReference type="GeneID" id="4388367"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02348"/>
    <dbReference type="eggNOG" id="KOG2396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026025_3_1_1"/>
    <dbReference type="InParanoid" id="Q2HBQ6"/>
    <dbReference type="OMA" id="YAKLEMI"/>
    <dbReference type="OrthoDB" id="28112at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="7">
        <location>
            <begin position="47"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ90413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="437" mass="48394" checksum="D3B437C8A6554793" modified="2006-03-21" version="1">MILECRTSKSFRHGPHFPARPLHPILGASSLRFGLVLTARSGLGGEQEQKFFTKDEIRSLVTKRSDFEHLILSPGTKPTDFLSYISWERSLDRLRAKRCRRLNLSRSSSSRASHARTFGIFERAVLKHPGCVPLWRAYLDFAAHEAGAAKRWRRICTRALRLHPTDAGLWVLAGRRAAMAGDMERARAHFLRGCRFCTGDVVLWVEYARCEMEWLARVEAKKAGKGVRKGVNVMEAVKATEAVQEGDIVLFDEEDEDDSGDEGGLMLPDPDAQGGKMAKAEVFDEEATRKMEQSPALSGAIPMAIFGIAKKQPFFGPAAAETFFDAFAGFGHVSSQAKIVQHVVDTMVELFPNHPCTCSCQIRQPLVGVDVLTAAFPKALRESLARLKVGMETTQDKKELANKVVAWTDVILAIEGLDAAVKTVLEHTKRSLEDSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBU3</accession>
    <name>Q2HBU3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228827.1">
        <property type="nucleotide sequence ID" value="XM_001228826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBU3"/>
    <dbReference type="GeneID" id="4388546"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02311"/>
    <dbReference type="HOGENOM" id="CLU_2637848_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HBU3"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="77" mass="8302" checksum="B45630F9129E6838" modified="2006-03-21" version="1">MSRRADPADQNHCGPHATVPAAVDFAAKEGPVDGRQRAGFGSCKLRYSLQDATAVGLHNEERRSVQKKTRDLASVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBY6</accession>
    <name>Q2HBY6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_02268</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228784.1">
        <property type="nucleotide sequence ID" value="XM_001228783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBY6"/>
    <dbReference type="FunCoup" id="Q2HBY6">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="GeneID" id="4388679"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02268"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001650_18_1_1"/>
    <dbReference type="InParanoid" id="Q2HBY6"/>
    <dbReference type="OMA" id="IASENKW"/>
    <dbReference type="OrthoDB" id="5017987at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF440">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="5">
        <location>
            <begin position="137"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="415"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ90333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1091" mass="124758" checksum="FB783F5AC8E476DD" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCA3</accession>
    <name>Q2HCA3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228667.1">
        <property type="nucleotide sequence ID" value="XM_001228666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCA3"/>
    <dbReference type="STRING" id="306901.Q2HCA3"/>
    <dbReference type="GeneID" id="4389847"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02151"/>
    <dbReference type="eggNOG" id="ENOG502SHSN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_7_0_1"/>
    <dbReference type="InParanoid" id="Q2HCA3"/>
    <dbReference type="OMA" id="CNMMCAN"/>
    <dbReference type="OrthoDB" id="3548654at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="104"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="810" mass="91339" checksum="69990C3B84CD172F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCF7</accession>
    <name>Q2HCF7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_02097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="entry name" value="WW domain"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="136"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
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        <location>
            <begin position="124"/>
            <end position="230"/>
        </location>
    </feature>
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        <location>
            <begin position="289"/>
            <end position="374"/>
        </location>
    </feature>
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        <location>
            <begin position="53"/>
            <end position="105"/>
        </location>
    </feature>
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            <end position="152"/>
        </location>
    </feature>
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        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
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        </location>
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        </location>
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            <begin position="352"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ93862.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="374" mass="40114" checksum="0DF366406457D83F" modified="2006-03-21" version="1">MAFFKKFTDGIADDLGRLGLGDNKNDRKDDASSSNRDGVNPPQPYSGSGHYQSPPPPQGDPYSHPPPHQSNYSSPPPQTPYAYPPEAGPRPPPPYTPPADKPPIPSGWTPRWDDHYQRWYYVEESSGRSQWEVPGYDHSSHRPHGDESRGHDTPGGGYFPHGAPTPGVPTPGYGSPYGAPQASPGGQPGYGGLPGYGQPSPYGGGYASPQPGHDDQRGSHKEKKSHSGMMMGAAGGLAVGAIAGAVIVSPTRSSQQAAYAAAPAAAAYAPPPEPAQEPAPTTIVYETNNYYYNEPPPPAPPADDEFERGVIPTHNAYGEEIDGSDRESLREARDDYEEALEAAASSSASSSEQEELEEAREEYEEEYEEAYYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="70" xmlns="https://uniprot.org/uniprot">
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                <person name="Untereiner W.A."/>
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                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
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    </dbReference>
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            <end position="1053"/>
        </location>
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        </location>
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        <location>
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        </location>
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        <location>
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            <end position="523"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="EAQ93820.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1443" mass="160562" checksum="6E1CC686E3537EA2" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCQ3</accession>
    <name>Q2HCQ3_CHAGB</name>
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        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="EAQ93766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="34218" checksum="AC390E5A385BB06C" modified="2006-03-21" version="1">MTVDSDVLDLPPGYEIRKLNNEHLSWVQAIVAHTMSFDSAVWSKVDYPGGATQRAYDMYHAIRQSSLQSIQSGLSYGVFCTEYKCRTPGLEGTLDWDFNDLSADDDDLLEQMDFPLVSIAMSKDAAEDKPVPETGVKPWSEIVPGHAIISNSLKAGDNRPQSVWSPEHMGEVVRRSGTHTRGDHAGKGLSKVLAHHIMREIRDHEQGYKAILIHTGGEAVDKVWLRPPAPFKSEEICPFSTSGYHRKDDHSDTSYNPFGSAKVVSRRIWVTWPLKEDKEELPVLNLRRRSAVVIADVKPKELVDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCZ0</accession>
    <name>Q2HCZ0_CHAGB</name>
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        <recommendedName>
            <fullName evidence="5">Lysyl-tRNA synthetase</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">CHGG_01914</name>
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    <organism evidence="8 9">
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070154">
        <property type="term" value="P:mitochondrial lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000094">
        <property type="entry name" value="Lysine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF5">
        <property type="entry name" value="LYSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="7">
        <location>
            <begin position="196"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ93679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="587" mass="64288" checksum="C0A4562E36C329EB" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDH2</accession>
    <name>Q2HDH2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_01732</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220953.1">
        <property type="nucleotide sequence ID" value="XM_001220952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDH2"/>
    <dbReference type="FunCoup" id="Q2HDH2">
        <property type="interactions" value="482"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HDH2"/>
    <dbReference type="GeneID" id="4386752"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01732"/>
    <dbReference type="eggNOG" id="KOG2429">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HDH2"/>
    <dbReference type="OMA" id="CTPLTRD"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF5">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="518"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="604"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ93497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1102" mass="120736" checksum="C1F72AE0AB541444" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEF1</accession>
    <name>NAR1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Cytosolic Fe-S cluster assembly factor NAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Nuclear architecture-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">NAR1</name>
        <name type="ORF">CHGG_01403</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cytosolic Fe/S protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NARF family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220624.1">
        <property type="nucleotide sequence ID" value="XM_001220623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEF1"/>
    <dbReference type="SMR" id="Q2HEF1"/>
    <dbReference type="FunCoup" id="Q2HEF1">
        <property type="interactions" value="332"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HEF1"/>
    <dbReference type="GeneID" id="4387726"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01403"/>
    <dbReference type="eggNOG" id="KOG2439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018240_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HEF1"/>
    <dbReference type="OMA" id="GYLHHVL"/>
    <dbReference type="OrthoDB" id="10253113at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1780:FF:000004">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor nar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000383724" description="Cytosolic Fe-S cluster assembly factor NAR1">
        <location>
            <begin position="1"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="586" mass="62179" checksum="3A75770ACC440D5F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEN4</accession>
    <name>Q2HEN4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220541.1">
        <property type="nucleotide sequence ID" value="XM_001220540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEN4"/>
    <dbReference type="GeneID" id="4387239"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01320"/>
    <dbReference type="eggNOG" id="ENOG502S9G7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1366095_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HEN4"/>
    <dbReference type="OrthoDB" id="4576724at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="200" mass="22369" checksum="C6D5748D1A6283A1" modified="2006-03-21" version="1">MATLQTHDAPGPAQVQAVIIRCNIDKIRSPPWSATTISADHPVFSQAVPFPPRAHRDPAGRPPRRHASHVGTVVAARKDKKPLLPHHLEGVWMYCDYILDLFGEGGGAPTRLYSRQAFEKWWGDYCEEQKRLRTGDGGEKDPDDCRAVRSPYEISPTLVATLSKLSLDGFSGDFTEPKNVLDKDIRETILKLERASEETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HER8</accession>
    <name>Q2HER8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220507.1">
        <property type="nucleotide sequence ID" value="XM_001220506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HER8"/>
    <dbReference type="GeneID" id="4388347"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01286"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_645570_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HER8"/>
    <dbReference type="OMA" id="PRWGKPE"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051122">
        <property type="entry name" value="SDR_DHRS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477:SF1">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="425" mass="45205" checksum="147EF1E1968FB904" modified="2006-03-21" version="1">MFGCSGHTPALSGPLQAEIGSAAIKDVVVTVTLSSLLAYQPTATHCMALLPPAFANPERHRNRGDLFCQACICPQDAQDTQDGRTRSRKRAGPVKCLPDRKSSCYDAPFKYQRLFSLLSSLLNPSSTCRKPTRIFNWYIQNRRSKMTIPPRVLVVLGCGGMGLATARRLGGGRKVLLGDYTQTNLDSAAKALRDEGQVVETHLVDVADFDSVQAFATAASKEGHIDAVVHTAGLSPAMAPPKRIYEVDLLGTANVIDAFQDIIPAGASLTCIASIARFNKNPSPELAAHLASAPRDQLLTTKHLLDIDAPDPEPAASYSLSKCANFLRVQAAARPWAARGARINCVSPGIIITPMIRQEMASPLGPAIQSMVDSTPMRRWGSPDEIAGVVAFLAGPDASYITGAEIVVDGGFMAGSRGAEAKEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HF05</accession>
    <name>Q2HF05_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220420.1">
        <property type="nucleotide sequence ID" value="XM_001220419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HF05"/>
    <dbReference type="GeneID" id="4387444"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01199"/>
    <dbReference type="eggNOG" id="ENOG502RJEU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1372038_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HF05"/>
    <dbReference type="OMA" id="VIILCPG"/>
    <dbReference type="OrthoDB" id="4589968at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="199" mass="20799" checksum="749C4DA36EB0AE67" modified="2006-03-21" version="1">MNDPDTLPPIDLPSPPTTILTLTKFHATLATLLLATTTTADRHVALVSALAYVHFWSATLGFAWWPVFHVLCLGLVGALVGDMVLVGLRVVEEGVVGGVEVGGVGGEKGGRGGGGTGNGYGWVWGLDQLVGVAAMVVVSGPLGLLVIILCPGIGWYLRRATRVLKWVFPYTASALWFILKWLLQESTGGVGVVLLGGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFQ8</accession>
    <name>Q2HFQ8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit OST2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_00946</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DAD/OST2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220167.1">
        <property type="nucleotide sequence ID" value="XM_001220166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFQ8"/>
    <dbReference type="FunCoup" id="Q2HFQ8">
        <property type="interactions" value="627"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HFQ8"/>
    <dbReference type="GeneID" id="4387147"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00946"/>
    <dbReference type="eggNOG" id="KOG1746">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111220_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HFQ8"/>
    <dbReference type="OMA" id="IGIWQNY"/>
    <dbReference type="OrthoDB" id="445566at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003038">
        <property type="entry name" value="DAD/Ost2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02109">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005588">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="8"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="169" mass="17695" checksum="FE0D0641FE08B516" modified="2006-03-21" version="1">MAPKQRNAAAASPAAAPARTPATTTTPITNTTTTTTTTPTTPASLKANAAGVVGNGGAQTWDRIAQNLVAHYTASTPQRTKLLDAFLAFLVTVGGLQFAYCVLAGNYPFNAFLSGFSATVGQFVLTASLRIQTTEANKGDFPAVSPERAFADYVVCSLILHFFCVNFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
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            <authorList>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <dbReference type="GeneID" id="4386930"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00797"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021434_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HG57"/>
    <dbReference type="OMA" id="GEMYHYR"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
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    </dbReference>
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        <property type="term" value="F:glycosyltransferase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN10-RELATED"/>
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    </dbReference>
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    </dbReference>
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            <end position="140"/>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ92562.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
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            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="59492" checksum="F1B5F4B42568B3C8" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG70</accession>
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        </recommendedName>
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    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
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        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        <location>
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        </location>
    </feature>
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            <begin position="390"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ92549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="56768" checksum="E403A5E58C3D0B27" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGQ0</accession>
    <name>Q2HGQ0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="1 2">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001219824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGQ0"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00604"/>
    <dbReference type="HOGENOM" id="CLU_2654270_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGQ0"/>
    <dbReference type="OrthoDB" id="10276706at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ92369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="76" mass="8221" checksum="C0E3EB5D46193C95" modified="2006-03-21" version="1">MDGLHAMRAVIFPQLKYRDTNAVTCTAQESEFQTLVWKRVFISSTPVFSGISAGVTCSVTMLNKLPPGSLGRPGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH49</accession>
    <name>Q2HH49_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_00455</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219676.1">
        <property type="nucleotide sequence ID" value="XM_001219675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH49"/>
    <dbReference type="STRING" id="306901.Q2HH49"/>
    <dbReference type="GeneID" id="4387575"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00455"/>
    <dbReference type="eggNOG" id="KOG0624">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015935_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HH49"/>
    <dbReference type="OMA" id="PFAHFQH"/>
    <dbReference type="OrthoDB" id="1726119at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000083">
        <property type="entry name" value="DnaJ and TPR domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051727">
        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140:SF2">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208952" description="J domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="349"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="407"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ92220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="464" mass="51608" checksum="C2661B4CFDAB732B" modified="2006-03-21" version="1">MMVRLSTLALAASILSAPSLRATTYLSLGRTSQATDDFQKVLTLQPGFEGAHVQLGKLKARFGDWDLAKEHYLQAKKTEELASLEEAKGAATLAEAAANSENWEECIKQADDAILTANRALSLRELRARCAFERGAMERGIGDLQHILQMKPGDTSPHVKISAIQFYALGELQDGMASIRKCLHSDPDSKECKRLLKLEKQVDKVIQKVTKALDKSQHMTAVRQLVPSGDDEGLIREVKDQVKLLREEGTIPRAAGNVLVARLVEMACQAYYESNSKKAKEYCEESFEHDENSFYGLLYRAKHLLDAEEFEASINTLRKAAEAHPGKEETINPLMQKAQVALKRSKTKDYYKVLGVAHDADERQIKSAYRKLSKVHHPDKAAKQGLTKEEAEKKMASINEAYEVLSNPELRARFDRGDDPNSHEQPQHHGNPFGGGHPFMFQQGGGGGQQFQFNFRGSGFPFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHD6</accession>
    <name>Q2HHD6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219589.1">
        <property type="nucleotide sequence ID" value="XM_001219588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHD6"/>
    <dbReference type="GeneID" id="4387835"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00368"/>
    <dbReference type="HOGENOM" id="CLU_868785_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHD6"/>
    <dbReference type="OrthoDB" id="10403284at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="320" mass="34069" checksum="5BA2229634BDFF93" modified="2006-03-21" version="1">MESPSTSSTKCKCLPPDFTPLGKGCKQPDECLGPGGAGIGDYCESCFHTARDSAVEREGSATNARATGLFMIAERAKDRSPVTSASSNPASASTSRHTERGDRLHSNPVASYRQRPLAPHEQPSQPHSDPITFYRHSAPPSSDHAGQADEPHGGPSTSHHQPAHLPTTNHTSPAAQLSGAPTTAYQQPPAVPPTTDDAAPQKQQLPYPELQPKPQPDTPLPPLTAREEPPQTTYDNTTNNTTNNDTTNDNSPPSLFFPAPSDGVGVGVDSVLSDHHPCVCQGTWTCRAGGLCEETIMFVEGDLCSLCEIFECGRWDEPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI00</accession>
    <name>Q2HI00_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">O-methyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219375.1">
        <property type="nucleotide sequence ID" value="XM_001219374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HI00"/>
    <dbReference type="GeneID" id="4387196"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00154"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_5_2_1"/>
    <dbReference type="InParanoid" id="Q2HI00"/>
    <dbReference type="OMA" id="FQTGMAG"/>
    <dbReference type="OrthoDB" id="1535081at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF16">
        <property type="entry name" value="O-METHYLTRANSFERASE ELCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="1">
        <location>
            <begin position="215"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="339" mass="37250" checksum="363BB08D7FC327AE" modified="2006-03-21" version="1">MASTPTFQLVPAAEELLTNAKKLAALTKPGDEDNELELRRSIAHTAKSIAFETAPGIDVIKSDWMVMADIAAWNIFIDWKAFDHIPLDGHISIHDLALALNAQESLIARISAQLLATHKLLPGPTPNTLRHSRISPLYRSTHPVSSLCTVAVGNAMKPFAHWPAYFNTITHNTHPHPPTRTTPPTQTNTPFAFAWGHPALSPWELKKEAETEAAKAEKRGVPVGNGCWGRKLTISGALVYLLRRVLLDYSDTLATGILRRLADALPADNSKARVIILEERLLEVPTPQNCLVDLVMLNLGGKLRNEAMFREIAVSAGLKVVGFYTREDDPNCVVECMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI56</accession>
    <name>Q2HI56_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_00098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219319.1">
        <property type="nucleotide sequence ID" value="XM_001219318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HI56"/>
    <dbReference type="GeneID" id="4387259"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00098"/>
    <dbReference type="HOGENOM" id="CLU_1331803_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HI56"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ91863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="206" mass="22802" checksum="1FABB08A0ED93892" modified="2006-03-21" version="1">MLHPDAVVSTIRGIEYTALEQAALCLCPSIVHRLLERGADPDQRSRTGATILYKVMANYDVHRWADGLPDGGQLIGMTVVALLMYGANPALRPYPPVLPDTATSEQSKIGASLFLLGIDSPYPQIRQHFAELLHRRVCERSVCRERMYDYGVPGADIPGHCAISRSQLTPEELRFAETVERGREADFREGPFGFGGWVGHGDVLVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HIA0</accession>
    <name>Q2HIA0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_00054</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219275.1">
        <property type="nucleotide sequence ID" value="XM_001219274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HIA0"/>
    <dbReference type="GeneID" id="4388277"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00054"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_6_1"/>
    <dbReference type="InParanoid" id="Q2HIA0"/>
    <dbReference type="OMA" id="NEHVEDK"/>
    <dbReference type="OrthoDB" id="2533084at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF181">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="65"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="256"/>
            <end position="285"/>
        </location>
    </feature>
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        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ91819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="534" mass="58279" checksum="CC05562FE627A509" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GLY6</accession>
    <name>Q2GLY6_CHAGB</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_11070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ82894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GLY6"/>
    <dbReference type="GeneID" id="4397390"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_11070"/>
    <dbReference type="eggNOG" id="ENOG502SBVF">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063948_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GLY6"/>
    <dbReference type="OMA" id="NTAHINP"/>
    <dbReference type="OrthoDB" id="10010954at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208769" evidence="1">
        <location>
            <begin position="26"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ82894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="310" mass="34460" checksum="2B0BE8C21B80FAB1" modified="2006-03-21" version="1">MFRLNITILALAWALLQTHLPQVHAWPTPPKWLPHFKSQRPQDDYAKRNLKTVSSIYNLTVYPNQLPIFQHGGVGVPDGLFSKDVVGRVDPVGNFTGFEDSIEYFFALSPLPQANAAKAAITGYKITEFSSQCRGVASSVVYLYCSVVDPGGPDHGKPLPPLKQIAFWRFDKYGAVVKYDAWIANLNSWFEATVGADVTDPYFRAASIEQICAASQMRCRGPNTQWHSIEECVAALSKKRYGSYDEAWGDNIVCRSIHLVLTQVRPDVHCAHVGLTGGGKCVEVSYPENFFSDETLYGDPPGQTFMCDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMJ8</accession>
    <name>Q2GMJ8_CHAGB</name>
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        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">CHGG_10806</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
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            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    <dbReference type="FunCoup" id="Q2GMJ8">
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    </dbReference>
    <dbReference type="GeneID" id="4397304"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10806"/>
    <dbReference type="eggNOG" id="KOG2533">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GMJ8"/>
    <dbReference type="OMA" id="TWRTTFY"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF57">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="59"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ82988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="507" mass="56386" checksum="2DFB52A74BE9B0AA" modified="2006-03-21" version="1">MGNPAEVAAPDVPTTESDSVSNEKTTTRKASHEDDVNVESAGWDESSTRRLIRKVDLTLIPFLALLYLLSFLDRTNIGNARLDTLEDDLGLDKTGLQYNDALAIFFPFYVAAEIPSNMAMKRFRPSLWIPSIMVAWAVCTTLMGIVKDYPGLMACRSALGLAEGGLFPGITYYITMWYRRHECGLRMAIFFSAATAAGAFGGLLAFGIMKMGGVAGLSGWQWIFILEGLLTFCVAMIAYMVMQDYPATAKFLTQEERVEVAARLKRDRSSLADEFDIKYFWAALKDWKIWVHMFITIGVYTGLYSYSLFLPTIINDLGTSSSREMSQLLTVPPYVVACLFCVGSGWYADKLGKRGIFMIGFMVIAIIGLIMLMSSSSSGVRYTGCFFLATGIYPNVPLGVAWNGNNIGGSLKRGVGIAMHVGFGNLGGTISAYLFLSKDKPRYMPGFATLLACQTMALVLSVFMHIYLRRENARRDREYKPPSEYTEEERVAEREKGDLATFFRYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMX8</accession>
    <name>Q2GMX8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_10676</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228603.1">
        <property type="nucleotide sequence ID" value="XM_001228602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMX8"/>
    <dbReference type="GeneID" id="4396326"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10676"/>
    <dbReference type="eggNOG" id="ENOG502SA90">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028892_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GMX8"/>
    <dbReference type="OMA" id="WNDRICE"/>
    <dbReference type="OrthoDB" id="5361565at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.510">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004207957" description="Peptidase A1 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ84272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="605" mass="63363" checksum="19BB8B8A586A621A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN78</accession>
    <name>Q2GN78_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_10576</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228503.1">
        <property type="nucleotide sequence ID" value="XM_001228502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN78"/>
    <dbReference type="STRING" id="306901.Q2GN78"/>
    <dbReference type="GeneID" id="4396630"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10576"/>
    <dbReference type="eggNOG" id="ENOG502QVJU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038296_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GN78"/>
    <dbReference type="OMA" id="MWRTELI"/>
    <dbReference type="OrthoDB" id="120072at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041524">
        <property type="entry name" value="GH131_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612">
        <property type="entry name" value="GH131_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612:SF6">
        <property type="entry name" value="GLYCOSIDE HYDROLASE 131 CATALYTIC N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18271">
        <property type="entry name" value="GH131_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208410" description="CBM1 domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="6">
        <location>
            <begin position="310"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="259"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="271"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ84172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="346" mass="36950" checksum="08C92E1B831D8B7C" modified="2006-03-21" version="1">MKFSVLSSILANALSVSAGTILWDGRFNDLSSSTDLNNWSWGNQVGPYQYYIHGSSSVTSYVNLSPDYKNPADSGSKQGAKITLDNTAYWNGQNMRRTELIPQTTAPIAQGKVYYHFSLMRKDTNAPATTREHQIAFFESHFTELKAGWLSGAPGVSDTLLRWCVGGQTKWSTEWEANVWHNVAYEIDFSANTVAFWHSTGGDALTQKIAPVSTSTSSNGADWHVGVLELPRSGYSDSNEDYYWSGVYIESGSLTTNVAGPGAPSGGGGSSSSAVSSSTKAPVSSSTTLATSTTTTPAPATSTTAGPVGCTAGQWAQCDGTGYSGCKACASPYKCNYVNDWYSQCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GP46</accession>
    <name>Q2GP46_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_10258</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228185.1">
        <property type="nucleotide sequence ID" value="XM_001228184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GP46"/>
    <dbReference type="FunCoup" id="Q2GP46">
        <property type="interactions" value="592"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GP46"/>
    <dbReference type="GeneID" id="4396088"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10258"/>
    <dbReference type="eggNOG" id="KOG0745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014218_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GP46"/>
    <dbReference type="OMA" id="HRSDFTN"/>
    <dbReference type="OrthoDB" id="1721884at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050052">
        <property type="entry name" value="ATP-dep_Clp_protease_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF7">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="192"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="5">
        <location>
            <begin position="443"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="304"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="545"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ83854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="579" mass="64832" checksum="A46018278DF4CD79" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPK0</accession>
    <name>Q2GPK0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228031.1">
        <property type="nucleotide sequence ID" value="XM_001228030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPK0"/>
    <dbReference type="GeneID" id="4396055"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10104"/>
    <dbReference type="HOGENOM" id="CLU_1239991_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPK0"/>
    <dbReference type="OrthoDB" id="10495849at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="223" mass="24117" checksum="6AF51AB330542215" modified="2006-03-21" version="1">MSGNQGNSASQTGGDQVAFDGQVGRRVPYVPDPIFPSWRVLTLKRAPQTTVTLIIQTLLQAGMTPQEIAAAFETAFTTHLNTNIVPLFPTCHVLLIQLQGQIAALRTQVEILQEANTSLQNRFVARGDRLMVLLSQMQDLRAQVAAATAAGWVPVVGNGGDEESFDEEEMDEDDETDEDDGTDNPHQTDNGDGMDRENGMDGGNETDGEDEMEENGGARLNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPZ8</accession>
    <name>Q2GPZ8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP-dependent DNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_09956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227883.1">
        <property type="nucleotide sequence ID" value="XM_001227882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPZ8"/>
    <dbReference type="GeneID" id="4396450"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09956"/>
    <dbReference type="eggNOG" id="ENOG502S808">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1049735_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPZ8"/>
    <dbReference type="OrthoDB" id="4751476at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ83552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="30021" checksum="65222183E6EF5545" modified="2006-03-21" version="1">MVLFFGDFFQFDPVLQTSLLLPAPRDHGGQRPESLAKHLAAHRLFLQFTTVVILQEQVRAAGCPRLRGFLGRLRNGEQTELDFQRLSQRLYTPSCKASFVDGLRAITPLNQDRWDLNMAAVVQWARAYGKHISIFVAKHDTESAKRLRVEELGDVLRHGKPGFRWVTHRTGPLCTPAFAMTDQKSQGKQFSDVLVNLKGVRGGGTATRPSFMSLYVQLSRAQSWDGLHLFRKPARSDFIEPKNVLDKDMRDAILKLERQVAIVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQN3</accession>
    <name>Q2GQN3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial acidic protein MAM33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_09721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227648.1">
        <property type="nucleotide sequence ID" value="XM_001227647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQN3"/>
    <dbReference type="FunCoup" id="Q2GQN3">
        <property type="interactions" value="414"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GQN3"/>
    <dbReference type="GeneID" id="4396967"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09721"/>
    <dbReference type="eggNOG" id="KOG2536">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072692_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQN3"/>
    <dbReference type="OMA" id="RWLNNVK"/>
    <dbReference type="OrthoDB" id="278212at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ83317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33147" checksum="8A0292D18EA22262" modified="2006-03-21" version="1">MMSVRSIARSAPRALARASTTSTISRYQRTSSILSARPTSLLRTQQVSAFSTSMLRKAMAGEVDEEVSAKLASEIDFEKDVKQNEPLPASIKDFLDNSPFKVEDVPGSENVVLTRMFGEEKITVTFSITDLHNYEPDMLDDQAMEDDLDDMEHGHSQQDQRGGAADLAQEGNEDLEAGEDETSVPCRLNIVIEKSNNKGALNIEAVAQDGAIVVENLYYYADAKLAHSTDANTVHAAQSTYPGPPFGSLDEDLQILMERYLEERGITQALAIFAPDYMDYKEQKEYMAWLKNVKGFIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQP4</accession>
    <name>Q2GQP4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227637.1">
        <property type="nucleotide sequence ID" value="XM_001227636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQP4"/>
    <dbReference type="STRING" id="306901.Q2GQP4"/>
    <dbReference type="GeneID" id="4396097"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09710"/>
    <dbReference type="eggNOG" id="ENOG502S89B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074184_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQP4"/>
    <dbReference type="OMA" id="WHDEWML"/>
    <dbReference type="OrthoDB" id="4850648at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37827:SF1">
        <property type="entry name" value="HNH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37827">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30359" checksum="D11A482BC798B7AA" modified="2006-03-21" version="1">MSEVIPEEYNTNYEQFRDILSSFLIERIATPFTKPKPKPKRRSKKKPTNSPPPTSPDITDTDPSADDLADFTSYIATATFLALPPDLQSLTYHTWIDNPHFESTLYPLPLTAERTTTLLHTLDPSIPDSLATYGITAPPSTTPSNLPSPAEFLAPVLGAYISATTVAPPPPASTKADAAGCEICGRDWINLSYHHLIPRMVHDKAVKRGWHRADQLQNVAWLCGACHRFVHRFAGHEVLAREYYTVERLLQAEEVRRFGEWVGRVRWKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GR40</accession>
    <name>Q2GR40_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_09564</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227491.1">
        <property type="nucleotide sequence ID" value="XM_001227490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GR40"/>
    <dbReference type="GeneID" id="4395031"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09564"/>
    <dbReference type="eggNOG" id="ENOG502S1A6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_1_2_1"/>
    <dbReference type="InParanoid" id="Q2GR40"/>
    <dbReference type="OMA" id="AYTPGYP"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ85550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="32484" checksum="B3C9FED36B0D0BE6" modified="2006-03-21" version="1">MSQRCRRVTSPHIEAVIWSHHHFDHTGNPNTFPPSTSLIVGPGFRSMLPGYPTNPDSTILESDLTSRQLIELDFSSGTSDNHTFKPLTIGRFRALDYFGDGSFYLLDTPGHAVGHISGLARVTPGPEGSFILLTGDAIHHPGEIRPSKYLPLPASIIPDPFAPDPHPLESHYGCPGATFESLFQGRGRPACGPVYEPARPERPDEAFNHNTDEALETVAKLQEADAHDNVFVAAAHDEALLDHVVFFPDGKMNEFAQKHWVKRVRWRFLRDFAGAVGKLDHEVGRRHWGHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRC9</accession>
    <name>Q2GRC9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_09475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227402.1">
        <property type="nucleotide sequence ID" value="XM_001227401.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GRC9"/>
    <dbReference type="GeneID" id="4395709"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09475"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_60_2_1"/>
    <dbReference type="InParanoid" id="Q2GRC9"/>
    <dbReference type="OMA" id="IQYTMLY"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000003">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF3">
        <property type="entry name" value="SIDEROPHORE SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="462"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1275"/>
            <end position="1351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ85461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1733" mass="187580" checksum="BE608BD4D730A40B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRU3</accession>
    <name>Q2GRU3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227238.1">
        <property type="nucleotide sequence ID" value="XM_001227237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRU3"/>
    <dbReference type="GeneID" id="4394852"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09311"/>
    <dbReference type="eggNOG" id="KOG3947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041441_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GRU3"/>
    <dbReference type="OMA" id="SRPRMHC"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="309" mass="33993" checksum="9164267F95D78DA0" modified="2006-03-21" version="1">MTQDIKTFKTRFLILSDTHAQPLVPPSVPVDVAIHCGDLTEQSKMAEFRTTMALLQGIDAPLVLVIAGNHDFTLDTEVYKKKAAEANRLYSIDPRDMAAVYGHFHHARVLLDTYSGIIFLDEGTHQFDLRNCARLTVYVSPFTPSADPDGGFQYRLGEQHDFAIDRSADVLFAAVARARPRLHCFGHIHEGWGAKLVTWRGETPSENPSHFTDIDYGASVVMETLATLRPGKWDDAEAVKEKETLAGMLAAQGYQQTSHCAGDDRAITPGKETLFMNAAIQPGPEDDGPRQLPWVVDIELPGIPATPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GS90</accession>
    <name>Q2GS90_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Delta(24)-sterol reductase</fullName>
            <ecNumber evidence="2">1.3.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_09164</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.3.1.72" evidence="2"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227091.1">
        <property type="nucleotide sequence ID" value="XM_001227090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GS90"/>
    <dbReference type="STRING" id="306901.Q2GS90"/>
    <dbReference type="GeneID" id="4395223"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09164"/>
    <dbReference type="eggNOG" id="KOG1262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025883_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GS90"/>
    <dbReference type="OMA" id="WVGRSAF"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050614">
        <property type="term" value="F:Delta24-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="24-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801:SF10">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14300)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ85150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="467" mass="52213" checksum="E908EC90EE1B34BC" modified="2006-03-21" version="1">MERHKAAVSKIASTVRSLFAAREPYRIFHGSTNSTRPRPSASSRTVDISALHNVLAVDTARRVALVEPNVPMDKLVEATLPHGLVPPVVMEFPGITAGGGFAGTAGESSSFRHGFFDETVNRVEMVMADGEVLEVTPGGGEGGFVSGGGGRGGDAGDDDAVGGAVDGGAEDHGVVVTGQLTDEMPTAGEKVQTFSGPWDPWFYLHAKEKTAPEKGVAGAAPVDYVPLAEYLFRYDRGGFWVGAAAFQYFKFVPFTRFFRWFLDDFLHTRMMYRALHGSGESARFVVQDIAMPFETTERFVDYTSSELDIWPLWLCPLKKRGPPTFHPFTTLPEGVEKKEEDMMLNVGVWGWGPSDSAEFVKKNRELENKVRELGGMKWLYAHTYYPQDEFWSMYGGRGWYDALREKYNAKTLPTVWDKVHVDPDVAGKKKRHWLKKQPPLGGFYGIYKSIQSKDYMKHRRALWKWKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSD7</accession>
    <name>Q2GSD7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_09117</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 81 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227044.1">
        <property type="nucleotide sequence ID" value="XM_001227043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSD7"/>
    <dbReference type="FunCoup" id="Q2GSD7">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GSD7"/>
    <dbReference type="GeneID" id="4394812"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09117"/>
    <dbReference type="eggNOG" id="KOG2254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005482_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GSD7"/>
    <dbReference type="OMA" id="EATGKCM"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1170">
        <property type="entry name" value="glycoside hydrolase family 81 endo-[beta] glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005200">
        <property type="entry name" value="Endo-beta-glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040720">
        <property type="entry name" value="GH81_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040451">
        <property type="entry name" value="GH81_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983">
        <property type="entry name" value="ENDO-1,3(4)-BETA-GLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983:SF0">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-D-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17652">
        <property type="entry name" value="Glyco_hydro81C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03639">
        <property type="entry name" value="Glyco_hydro_81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52008">
        <property type="entry name" value="GH81"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208561" description="glucan endo-1,3-beta-D-glucosidase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 N-terminal" evidence="11">
        <location>
            <begin position="184"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 C-terminal" evidence="12">
        <location>
            <begin position="508"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 C-terminal" evidence="12">
        <location>
            <begin position="594"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="41"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ85103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="696" mass="75104" checksum="7D83C9A8457680C7" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTD8</accession>
    <name>Q2GTD8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226693.1">
        <property type="nucleotide sequence ID" value="XM_001226692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTD8"/>
    <dbReference type="STRING" id="306901.Q2GTD8"/>
    <dbReference type="GeneID" id="4395740"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08766"/>
    <dbReference type="eggNOG" id="ENOG502RJH1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002672_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTD8"/>
    <dbReference type="OMA" id="MGLFNKP"/>
    <dbReference type="OrthoDB" id="5335210at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
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            <begin position="500"/>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTG4</accession>
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        </recommendedName>
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
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                <person name="Untereiner W.A."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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    <dbReference type="OrthoDB" id="4571338at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        </location>
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        <location>
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        <location>
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    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ84710.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="705" mass="75833" checksum="DAF1EFEDE9B1DDA6" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTY3</accession>
    <name>Q2GTY3_CHAGB</name>
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        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
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        <name evidence="5" type="ORF">CHGG_08571</name>
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001226497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTY3"/>
    <dbReference type="GeneID" id="4395473"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08571"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001613_3_0_1"/>
    <dbReference type="InParanoid" id="Q2GTY3"/>
    <dbReference type="OMA" id="ELISAHH"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF6">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="53"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="4">
        <location>
            <begin position="289"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ84557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="482" mass="53240" checksum="DC21D5F4D9EE2DCA" modified="2006-03-21" version="1">MGLRPISRGTDTEGTATVPRIQYGTRRTITVPHVPSRRAKNENRRPPPLRLQIDGGGGTGKSYMVKVISSHLQAKAASYGRPSPIVRAAPTSVASNQIGGQTLHSLLRLPVDGNYRSLSETLTTLNALQRRFGGIHYLVIDEKSMLGLKTLAWIDQRLREVFPANRDEFFGGLSVILIGDFFQLPPVLNKPLYSTRDDLKDIEMVGRNAYLSFDKSVFLTTIQRQQGEDQAPFRRALEELRKADVSTQVVEYNHQHMLGLDSPAIQVEAKHEGVGAEKVESSNAVNLAKRLPLCFGCRVMLTRNLWADVGLVNGAQGTVYDISWKEGADVLRDPPEVIMVAFDDYDGPAFTMPNGEPLRSGEKLAVPILRVRQDFMVGANSCSREQFLMLVSYAITVRKSQGITLDKVVCDISAPKFASGLSYVAVSRVKTLGGLMFERPFDRSRIYRETPSRAMGLKLSDHATRQLQALDAVAGEVPSESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTZ0</accession>
    <name>Q2GTZ0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226491.1">
        <property type="nucleotide sequence ID" value="XM_001226490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTZ0"/>
    <dbReference type="GeneID" id="4395276"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08564"/>
    <dbReference type="eggNOG" id="ENOG502S685">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110797_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTZ0"/>
    <dbReference type="OMA" id="NPSDPIH"/>
    <dbReference type="OrthoDB" id="3260716at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="190" mass="19799" checksum="4F7286E639AB200B" modified="2006-03-21" version="1">MSANPDSVTNQGEFHSRVPPSKPMTTSGHQLGQQTGNEAIPEFRAETHTPGTAPSKDTYQPNPLHTTPGQALNPDAFRPEAAGHTGALDMPGATSGDVHSASTFARPMEGQTGRELHGAHAVGKRKKERSGLEGVGATDNREEETVEGRARALGADLPEGVERGVKVSGPGAEERVPVGAEEVAAERGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUB3</accession>
    <name>Q2GUB3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226368.1">
        <property type="nucleotide sequence ID" value="XM_001226367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUB3"/>
    <dbReference type="STRING" id="306901.Q2GUB3"/>
    <dbReference type="GeneID" id="4395870"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08441"/>
    <dbReference type="eggNOG" id="ENOG502SCP9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068080_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GUB3"/>
    <dbReference type="OMA" id="APFYPEW"/>
    <dbReference type="OrthoDB" id="9976870at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="68"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="245" mass="27390" checksum="0F2AD9D867F810B2" modified="2006-03-21" version="1">MPTGTAASPGQVVLPHVIEDDGSLSISALGGAMVTRVLPEATADKTREFHFEVVIHPDHPRLRGLPPPPAHFHPYQEEYFHVVQGALGVELDGVERVLRPEDGELAVRRGVNHRLCFPSGEDASLDPIRFYVSGEKTATAFALDLTFLENWYGYQEEVVVHGKKLDMIQVLSMWDTGGTYLTLPWWVPFRSTVSLAMGVVVGRWIGGLLGYQPFHRCWTTDWDLACAKMETSVFQRRFADRTKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUC2</accession>
    <name>Q2GUC2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_08432</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226359.1">
        <property type="nucleotide sequence ID" value="XM_001226358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUC2"/>
    <dbReference type="GeneID" id="4395726"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08432"/>
    <dbReference type="eggNOG" id="KOG4231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003208_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUC2"/>
    <dbReference type="OMA" id="HMTIDEC"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07216">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="19"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="23"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="63"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="4">
        <location>
            <begin position="211"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ84418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1213" mass="135555" checksum="4EBEC3408D2A286E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUF7</accession>
    <name>Q2GUF7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08397</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226324.1">
        <property type="nucleotide sequence ID" value="XM_001226323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUF7"/>
    <dbReference type="GeneID" id="4395039"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08397"/>
    <dbReference type="eggNOG" id="ENOG502S1W9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019533_3_1_1"/>
    <dbReference type="InParanoid" id="Q2GUF7"/>
    <dbReference type="OMA" id="NEVQTYT"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02182">
        <property type="entry name" value="GH16_Strep_laminarinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF60">
        <property type="entry name" value="GRAM-NEGATIVE BACTERIA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208631" description="GH16 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="13"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="284" mass="30504" checksum="1E1484C78E1B96D3" modified="2006-03-21" version="1">MRSTLLLLSLLTSLVSATPAPVYPGFKTLWSEAFEGNAGDTPNRSRWNLITDVRTNGEIQTYSTSNRNLQISGGGTVQLVPLKSKSGKWTSARIETKATFTPARGKLTMFEAAIRFGDNPASLRQGLWPAFWMLGDAVHHGTEWPLCGELDIMETVNGLPTAHGTTHCGVGEKGGPCNEPIGRGGSVALPDNGWHTWTLQVDRTNAEGGWKGEVIRWLIDGKVFHQVSGADLGDEGIWATLAHSPMFMILNVAVGGSWPGDPNAATAGSYGSMMEVEYVAVYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUP2</accession>
    <name>Q2GUP2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">R3H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CHGG_08312</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Regulates global gene expression after oxidative stress. Interacts and stabilizes mRNAs and may regulate their transition between different cytoplasmic components after oxidative stress.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with csx1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ87059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225968.1">
        <property type="nucleotide sequence ID" value="XM_001225967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUP2"/>
    <dbReference type="STRING" id="306901.Q2GUP2"/>
    <dbReference type="GeneID" id="4394134"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08312"/>
    <dbReference type="eggNOG" id="KOG0108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022096_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GUP2"/>
    <dbReference type="OMA" id="GMQRDDS"/>
    <dbReference type="OrthoDB" id="434258at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02639">
        <property type="entry name" value="R3H_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12253">
        <property type="entry name" value="RRM_PIN4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.50:FF:000002">
        <property type="entry name" value="Immunoglobulin mu DNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000183">
        <property type="entry name" value="R3H domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034186">
        <property type="entry name" value="PIN4-like_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034069">
        <property type="entry name" value="R3H_Cip2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF17">
        <property type="entry name" value="RNA-BINDING PROTEIN PIN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="191"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="R3H" evidence="16">
        <location>
            <begin position="347"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="274"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="447"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="557"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="325"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="619"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAQ87059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="638" mass="69196" checksum="5A32CD79DB3D3562" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUT8</accession>
    <name>Q2GUT8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease</fullName>
            <ecNumber evidence="9">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_08266</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="9"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ87013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225922.1">
        <property type="nucleotide sequence ID" value="XM_001225921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUT8"/>
    <dbReference type="FunCoup" id="Q2GUT8">
        <property type="interactions" value="393"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GUT8"/>
    <dbReference type="GeneID" id="4394191"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08266"/>
    <dbReference type="eggNOG" id="KOG2299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036532_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUT8"/>
    <dbReference type="OMA" id="REECRFF"/>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:ribonuclease H2 complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:RNA binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:DNA replication, removal of RNA primer"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000016">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="11">
        <location>
            <begin position="59"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ87013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="344" mass="36532" checksum="05BCC55F39FE7CB8" modified="2006-03-21" version="1">MDNSQQAGDVALETRPPSIVPPSINESALLSGESYSYYSPVPPALLPPPDSPPSATGPPCALGVDEAGRGPVLGPMVYGVFYLPIPLSDPLLRTTHHFDDSKVLTPAVRASLMETLCTPTSDLYESCGWAVDALSARDIGAGMLRPGLGAYNLNAQAMDATVELIKGVYARGVNVREIYVDTIGQPAAYQAKLARVFPAAKVTVAKKADSLYPSVSAASVCAKVTRDVALETLWKARGGGGEEGVEETMAWGSGYPSDGRCVTWLKSNMHPVWGWGPECRFSWGTAKDMIEATPAKGGGVNVEWPVDEDADTQRLIDYFASTGQEKDGDELGTWFGTPTGLEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUW2</accession>
    <name>Q2GUW2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225898.1">
        <property type="nucleotide sequence ID" value="XM_001225897.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4393645"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08242"/>
    <dbReference type="eggNOG" id="ENOG502QS15">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_259505_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUW2"/>
    <dbReference type="OrthoDB" id="5312133at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018562">
        <property type="entry name" value="ARS-binding_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42055">
        <property type="entry name" value="YALI0E03476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42055:SF1">
        <property type="entry name" value="YALI0E03476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09441">
        <property type="entry name" value="Abp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1176"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1286"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="555"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1316"/>
            <end position="1325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1325" mass="146191" checksum="48084084A6E8D873" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUY0</accession>
    <name>Q2GUY0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Septation initiation network scaffold protein cdc11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_08224</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225880.1">
        <property type="nucleotide sequence ID" value="XM_001225879.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GUY0"/>
    <dbReference type="GeneID" id="4393812"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08224"/>
    <dbReference type="eggNOG" id="KOG0531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002093_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUY0"/>
    <dbReference type="OMA" id="ATSWGTD"/>
    <dbReference type="OrthoDB" id="7451790at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061499">
        <property type="term" value="C:outer plaque of mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031028">
        <property type="term" value="P:septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052574">
        <property type="entry name" value="CDIRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566:SF1">
        <property type="entry name" value="PROTEIN NUD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
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            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="466"/>
        </location>
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        </location>
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        </location>
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    </feature>
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            <begin position="876"/>
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        </location>
    </feature>
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        </location>
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        <location>
            <begin position="1784"/>
            <end position="1827"/>
        </location>
    </feature>
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        <location>
            <begin position="30"/>
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        </location>
    </feature>
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            <begin position="60"/>
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        </location>
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        </location>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ86971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1827" mass="201308" checksum="688A1DA95259D0A9" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUY3</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08221</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225877.1">
        <property type="nucleotide sequence ID" value="XM_001225876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUY3"/>
    <dbReference type="STRING" id="306901.Q2GUY3"/>
    <dbReference type="GeneID" id="4394029"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08221"/>
    <dbReference type="eggNOG" id="ENOG502S84A">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_1038289_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUY3"/>
    <dbReference type="OrthoDB" id="4590138at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39474:SF1">
        <property type="entry name" value="FUNGAL SPECIFIC TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39474">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="61"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
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        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
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        <location>
            <begin position="145"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="268" mass="27170" checksum="CEE0324F2D5B158B" modified="2006-03-21" version="1">MPIRIPAARLQAACSRPLPATLSRALLGTVPPRTATRTRIREQVQPSVQSLLLRNKMSSKAGFSPATSTTAAISGSSTSSPAPASSTPPRPGSSPSAAAASASVATAAAAGASTAAAATAADAGANSGGAAPAPPSQHSQEPETEQQQQPQPTVTNTTTRNNGAITTTTDTSAAPTAPTLPALPEPEQGTTTTTIHVNGQAVALDSLGPMVVNRDGTVSRIGNWHEMSGIERQNTLRILGRRNQLRLGNLRAGRPADGESGEGDKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV00</accession>
    <name>Q2GV00_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_08204</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001225859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV00"/>
    <dbReference type="STRING" id="306901.Q2GV00"/>
    <dbReference type="GeneID" id="4393525"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08204"/>
    <dbReference type="eggNOG" id="ENOG502S1H2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1288765_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GV00"/>
    <dbReference type="OMA" id="VSDCAQM"/>
    <dbReference type="OrthoDB" id="4590657at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF1">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CFEM" evidence="17">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="82"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="134"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ86951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="214" mass="21116" checksum="188433C36D00CFBC" modified="2006-03-21" version="1">MKPASPHLAWLAAVTVNAVDFPSNMPKDDIACMCKATDWNNGIRDCSVESCPSIDQANVVISWGNSLCSGVGVTTAVVPTATSVKSSGSTSGAPATNTGDADSTSTGSGSDNDASETGDATAITTSTWTSTFTSGDATSTVTGTTTISGVNGVPGASDVPETTGTSPIVSTHTDESTTFETTIGSTTFTSSGAHMTAAPAIGFLAAAGIAAAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVJ5</accession>
    <name>Q2GVJ5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_08009</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ86321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="128" mass="13715" checksum="384139684A35526E" modified="2006-03-21" version="1">MAAPVAAIPSTDVDMVSDSMDTVSPPLRRRTNLPALDNDSAQQIINAITQVGAQLIDRIDQLGESVNRLEGSIGRLEGSVDRLEGSVSRLEGSVDRLEQTVNNPTNHIALLEGSVNTLTDTLNALQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX59</accession>
    <name>Q2GX59_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_07445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225101.1">
        <property type="nucleotide sequence ID" value="XM_001225100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX59"/>
    <dbReference type="GeneID" id="4393793"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07445"/>
    <dbReference type="eggNOG" id="ENOG502S17S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053910_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GX59"/>
    <dbReference type="OMA" id="DWRCTFL"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46830:SF2">
        <property type="entry name" value="ALPHA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46830">
        <property type="entry name" value="TRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ86192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="43436" checksum="9EB06DBF87E7E75E" modified="2006-03-21" version="1">MLTAAKALVPASWGRVPLRYVIVGATFLSLILLLATNHTRSYLPSWPSQASAPASSAGDIIPNTVHLVYILPEDATDFTFQFSHFLCIFAANHHLRPQTIYLHTNTDTHSAAYQRAANGTTGKWNRLIFTHFPHLQLRQVAVPTHASNGKALQNMEHRSDFVRVRAVHDLGGVYLDWDAHALRDLAPLRRAGFKAVGGRQLGGQVNSGTFMSAAKGRLIRLWMERMGKVYTGGWTDHSNAELTRIAERLVADPGGREVLIMEREAFAPGSWQTEDTDMLFQVHEDAPSALEGKKQGDGLAEYREGFEERWDHPERFPKWARDWSATYLLHAFSPHRWGHKVPGFEQITPRYVLERRSNFARAVYPMAKLMYDQGLIEIDDPWSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXC3</accession>
    <name>Q2GXC3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocation protein sec72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_07381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225037.1">
        <property type="nucleotide sequence ID" value="XM_001225036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXC3"/>
    <dbReference type="FunCoup" id="Q2GXC3">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GXC3"/>
    <dbReference type="GeneID" id="4393530"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07381"/>
    <dbReference type="eggNOG" id="ENOG502S442">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090376_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GXC3"/>
    <dbReference type="OMA" id="KMYTLAI"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF3">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ86128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23310" checksum="844D13D16CFE62F7" modified="2006-03-21" version="1">MSDLESFDFIPLHIDPKSKAISAAAQTPATRALEAELASLNALHRSLHGLDPPHLVPPPPVPVNPKRSANIGKLRESGNAEYRKQRYAEAAKFYTLGLQMALTRAAWEPSQLVREELHALYSNRAQANMHLGLWPEAASDAEASVEAKRQGNAKAWFRRGRSLVEMGRLAEAREWVARGLEFEGEEKELIELLKEVDAKLEAEKVKRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXI3</accession>
    <name>Q2GXI3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein SSH4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein ssh4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CHGG_07321</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SSH4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224977.1">
        <property type="nucleotide sequence ID" value="XM_001224976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXI3"/>
    <dbReference type="FunCoup" id="Q2GXI3">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GXI3"/>
    <dbReference type="GeneID" id="4394075"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07321"/>
    <dbReference type="eggNOG" id="KOG1477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016552_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GXI3"/>
    <dbReference type="OMA" id="FFFKYTR"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000065">
        <property type="entry name" value="Ear1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="18">
        <location>
            <begin position="78"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="313"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="386"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="410"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="452"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAQ86068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="508" mass="55638" checksum="2380A15E05D49BBA" modified="2006-03-21" version="1">MANYSPGLNGIVIGLLSSFGSAILILTIFLVFYFFRYTASGRIFLDRIGRPGEYDDEQAFAREEAEALETMDDMERTEYLRAKVFIAANPPESVQTDISLSQYLAIQEKGVSAWEFEPELEIANCFVEARTEIEFFDSECTVMSNLPVPKQNDVYYWEAKIYEKPDNTLLSIGMATKPYPLFRLPVGFHKSSVAYISNGTRRHNQPFYGTPYGPQIVQGDVIGVGYRPRTGTIFFTRNGKKLEDAMHGLKSQNFFPSIGANGPCIVHVNFGQAGFVFIEANVKKWGLAPMTGSLAPPPPYGVEADTVLLATGTKDGFTSSPARGHQYSHSAQLYRQGPNASDRGHTRSRSGNFRMLSPTSPGPLRSPTDISLAHLVPTDDDGEPSGSASSLGNTNQDQGHQPTVLGFGLHHQDNRPPPEYTSPEHSDAEEPSSQRHSSDSENAPLIRLTRSRGASSATVRSNNNRSTPPQARGPPSPPIPTYQDAIRQGAGRDRSDSARSGRSARGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXK7</accession>
    <name>Q2GXK7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7 11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_07297</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 10 11">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7 11"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224953.1">
        <property type="nucleotide sequence ID" value="XM_001224952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXK7"/>
    <dbReference type="STRING" id="306901.Q2GXK7"/>
    <dbReference type="MEROPS" id="C12.009"/>
    <dbReference type="GeneID" id="4394295"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07297"/>
    <dbReference type="eggNOG" id="KOG2778">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018316_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GXK7"/>
    <dbReference type="OMA" id="YIQYEIQ"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071629">
        <property type="term" value="P:cytoplasm protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09617">
        <property type="entry name" value="Peptidase_C12_UCH37_BAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000009">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017390">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041507">
        <property type="entry name" value="UCH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18031">
        <property type="entry name" value="UCH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038120">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 10" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="13">
        <location>
            <begin position="4"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 10">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 10">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="9 10">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ86044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="339" mass="37258" checksum="92CA3C2D36EECC9E" modified="2006-03-21" version="1">MSGGWNTIESDALQGVFTYLLDNLGVKDVQFEELLSLDPDALAQLYPVYGVIFLFKFPTDTPYHAGDKPLDGTFDEDASERLFFAAQTIQNACGTQALLSVLLNKTPDGTTPPDETINIGPTLTDFRDFTMALPPEYRGEALSNSELIRDVHNSFARSSPFADETQRQAGDEGEDAFHFVAYTAVNGTLYELDGLQRAPISHGPCGGPGQEGGEAGFPARVMEVLQRRVARYDAAEIRFNLLAMVRDLRVRAREIGDPEMLAREERKRRDWQFENALRRHNFVGFAGEVLKGVVAAKLKEGGGAYETWVEQGKQKMLKRAEERKKGAGGGGGGDVEMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXM9</accession>
    <name>Q2GXM9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_07275</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224931.1">
        <property type="nucleotide sequence ID" value="XM_001224930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXM9"/>
    <dbReference type="FunCoup" id="Q2GXM9">
        <property type="interactions" value="288"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GXM9"/>
    <dbReference type="GeneID" id="4394558"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07275"/>
    <dbReference type="eggNOG" id="KOG4031">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069856_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GXM9"/>
    <dbReference type="OMA" id="FYENYNT"/>
    <dbReference type="OrthoDB" id="5512at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF7">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="134"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ86022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="239" mass="25869" checksum="A418683F3C8F01F3" modified="2006-03-21" version="1">MADRFPSLDDFDSGAQTDVKDTSDVPSASNFLEREKAILGDDATQFATVEDAEFDEGDDDLLGGGGGVSSPGNNAAFESQFPDLSSPNEGVAPGGTITGGPSVSYNSGYQPHAEDEEEPEVIKEWREKRDAQIAKRAEQFAQQREETVREAQQNIDDFYENYNNKKEKTIAQTRKDAEQFLANREDTTSGGTSWERIAKLVDVSGKGAKGGAAGSGKERFRELLVSLRKDEKAPGAGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYI1</accession>
    <name>Q2GYI1_CHAGB</name>
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        <submittedName>
            <fullName evidence="5">60S ribosomal protein L30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_06973</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224629.1">
        <property type="nucleotide sequence ID" value="XM_001224628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYI1"/>
    <dbReference type="FunCoup" id="Q2GYI1">
        <property type="interactions" value="1057"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GYI1"/>
    <dbReference type="GeneID" id="4393870"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06973"/>
    <dbReference type="eggNOG" id="KOG2988">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130502_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GYI1"/>
    <dbReference type="OMA" id="YFQGGNN"/>
    <dbReference type="OrthoDB" id="1928736at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048025">
        <property type="term" value="P:negative regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00481">
        <property type="entry name" value="Ribosomal_eL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000231">
        <property type="entry name" value="Ribosomal_eL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="13"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ85720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="108" mass="11575" checksum="2E597A660673335E" modified="2006-03-21" version="1">MAPKKNKSEAQSIGSKLALVIKSGKVVLGYRSTLKALRSGKAKLILISANTPPLRKSELEYYAMMSKTAVHHYTGTNIELGTACGKLFRCSTMAILDAGDSDILSDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYI5</accession>
    <name>Q2GYI5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224625.1">
        <property type="nucleotide sequence ID" value="XM_001224624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYI5"/>
    <dbReference type="STRING" id="306901.Q2GYI5"/>
    <dbReference type="GeneID" id="4393866"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06969"/>
    <dbReference type="eggNOG" id="ENOG502RYPA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006963_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYI5"/>
    <dbReference type="OMA" id="CNHHACY"/>
    <dbReference type="OrthoDB" id="5427134at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="873"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1189"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="689"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="770"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="888"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="913"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="964"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1101"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1123"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1199"/>
            <end position="1209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1209" mass="130755" checksum="E834D24911345BB9" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYM5</accession>
    <name>Q2GYM5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224585.1">
        <property type="nucleotide sequence ID" value="XM_001224584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYM5"/>
    <dbReference type="GeneID" id="4393983"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06929"/>
    <dbReference type="HOGENOM" id="CLU_1081830_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYM5"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="257" mass="27806" checksum="D97A41E5EF45559A" modified="2006-03-21" version="1">MGDAGRVDPDVVVAEEAAEVVDGGWVWAVAPGVLGDVEETHSARFEAEEKRFFRGTCWAHPPPRIARRAPSRVRVRGSTSPTTDICHTQIKSSNSSTPATPRRLPTARASNPLSQAQPTPQRRKRTQPRPPKGTAPHLKPSIRRRLSQVELVKSPEVDRGFERLKIKAAQRPSLLTAPKATKRGRVSEVAPEAAPPRKQASKRNAVLSTTSQSSEQVQAGSAAQTQAVQDPSPPMTRTRSGRAVKPSAKLRGAAQEV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-03-18" modified="2025-04-09" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZN9</accession>
    <name>NST1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Stress response protein NST1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">NST1</name>
        <name type="ORF">CHGG_05007</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <text evidence="1">May act as a negative regulator of salt tolerance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NST1 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZN9"/>
    <dbReference type="SMR" id="Q2GZN9"/>
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    <dbReference type="GeneID" id="4391581"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05007"/>
    <dbReference type="eggNOG" id="ENOG502QSSK">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_002935_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GZN9"/>
    <dbReference type="OMA" id="EEDTQYG"/>
    <dbReference type="OrthoDB" id="21629at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051195">
        <property type="entry name" value="Fungal_stress_NST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025279">
        <property type="entry name" value="NST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31780:SF10">
        <property type="entry name" value="LD36051P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31780">
        <property type="entry name" value="STRESS RESPONSE PROTEIN NST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13945">
        <property type="entry name" value="NST1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword id="KW-1185">Reference proteome</keyword>
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            <end position="1255"/>
        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="3">
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        <location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="1255" mass="137927" checksum="10EECD026CBB3F67" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZP5</accession>
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            <taxon>Sordariomycetes</taxon>
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                <person name="Untereiner W.A."/>
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            <end position="155"/>
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        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ88382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="271" mass="29706" checksum="8520680CF88CDF8F" modified="2006-03-21" version="1">MARGKWRERIRRARRRLLRRQGQCIIQDSPTFAPYGQPFQQASCAPNDPHIPVIQIGPNQPSYYYPPLRLQDNLRRYHTPHQSTFDLTLPIPPSGISQRYPTRSSPKGLALSLKSLSLKGSSIRSSSPKTSSPKTSSAKTPPSAKTSSSTKTSISDYQPDQPKPKTSRSVISLLSSRMSTKTQHGSLHSSRWSFGSNRTMRSVRPDISHFTADDTNPSPHSGMTPPKASAGPIIPPRLRRPSSLSGGRGQYLPTPPPTPPLSSSDVVLPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
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                <person name="Untereiner W.A."/>
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    </feature>
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            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="22"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ88368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
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    </evidence>
    <sequence length="53" mass="5602" checksum="9C058A0D328F627F" modified="2006-03-21" version="1">MAGGVDLSRDSGADVRDRPAARPGPPAQKSAPVPPVRIPTEARSMHAPHQHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZR5</accession>
    <name>Q2GZR5_CHAGB</name>
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        <recommendedName>
            <fullName evidence="2">Cellobiose dehydrogenase-like cytochrome domain-containing protein</fullName>
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    </protein>
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            <taxon>Sordariomycetes</taxon>
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Untereiner W.A."/>
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        <source>
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        </source>
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    </dbReference>
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        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
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        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="280"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Cellobiose dehydrogenase-like cytochrome" evidence="2">
        <location>
            <begin position="21"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="Pfam" id="PF16010"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ88362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="357" mass="39326" checksum="3AE14595883284E5" modified="2006-03-21" version="1">MLLNGRNSNPRWRLQWLVLYHKGVTVSPRRTTGNTEPVHSPDTKLTIHETTINDNFDMIVNATCHGCQSFTKTDSAAPMMFAVGPGLDLSSDDLDARIRRHSAYGRFTINLLRATLPGGIPPSASTPNPNTTTPDVILSFTNNDDTTTTTNPTATFRLHQSGDAKAATAHGILYAIVALAVAPFDSLVAGALGSRWAWVHGVTATVYVAFVVGAMVPGVIVGREHVATQQFRTGHQILGLLTVVALTLMFFWGIALSWIKRSAKKRGQEPPESTRMLGDIHRWVCRVIWVLLLVNVGVGLKLSEQRMVLILAYVALAVGVIIVLVPIYFCLWRIQKKRKEKEEGLEMPTIYDHHGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZU4</accession>
    <name>Q2GZU4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224166.1">
        <property type="nucleotide sequence ID" value="XM_001224165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZU4"/>
    <dbReference type="STRING" id="306901.Q2GZU4"/>
    <dbReference type="GeneID" id="4392764"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04952"/>
    <dbReference type="eggNOG" id="ENOG502RHTK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012355_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZU4"/>
    <dbReference type="OrthoDB" id="4563615at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="639" mass="71166" checksum="96C3CDF7D510BF81" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZY0</accession>
    <name>Q2GZY0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial distribution and morphology protein 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_04916</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MDM31/MDM32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224130.1">
        <property type="nucleotide sequence ID" value="XM_001224129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZY0"/>
    <dbReference type="FunCoup" id="Q2GZY0">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="GeneID" id="4391545"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04916"/>
    <dbReference type="eggNOG" id="ENOG502QQJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016236_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GZY0"/>
    <dbReference type="OMA" id="DFLCAEN"/>
    <dbReference type="OrthoDB" id="17678at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012571">
        <property type="entry name" value="Mdm31/Mdm32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068:SF0">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08118">
        <property type="entry name" value="MDM31_MDM32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="248"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="763"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="131"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="628"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ88297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="784" mass="87053" checksum="8B8FBD9920BD22A8" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H036</accession>
    <name>Q2H036_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224074.1">
        <property type="nucleotide sequence ID" value="XM_001224073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H036"/>
    <dbReference type="STRING" id="306901.Q2H036"/>
    <dbReference type="GeneID" id="4392689"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04860"/>
    <dbReference type="HOGENOM" id="CLU_2454524_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H036"/>
    <dbReference type="OrthoDB" id="77201at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208363" evidence="1">
        <location>
            <begin position="20"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="89" mass="9919" checksum="78653287F41528C1" modified="2006-03-21" version="1">MRLTLNLAALAAAFSSALAAHQGFNYGAFFTDNSPKMQSDFEAEFRAAQNLQGAPGTGFNSARLYTMVEVWRGATLRVPRRFEWPFLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0K3</accession>
    <name>Q2H0K3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_04693</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223907.1">
        <property type="nucleotide sequence ID" value="XM_001223906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0K3"/>
    <dbReference type="STRING" id="306901.Q2H0K3"/>
    <dbReference type="GeneID" id="4391636"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04693"/>
    <dbReference type="eggNOG" id="KOG0342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_26_6_1"/>
    <dbReference type="InParanoid" id="Q2H0K3"/>
    <dbReference type="OMA" id="TQREGCH"/>
    <dbReference type="OrthoDB" id="193716at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="166"/>
            <end position="297"/>
        </location>
    </feature>
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        <location>
            <begin position="337"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="573"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="582"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="605"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ88074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="640" mass="70435" checksum="51EBC1A9A95ACB7E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0M9</accession>
    <name>Q2H0M9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223881.1">
        <property type="nucleotide sequence ID" value="XM_001223880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0M9"/>
    <dbReference type="STRING" id="306901.Q2H0M9"/>
    <dbReference type="GeneID" id="4391815"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04667"/>
    <dbReference type="eggNOG" id="ENOG502S8W8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_44_1_1"/>
    <dbReference type="InParanoid" id="Q2H0M9"/>
    <dbReference type="OMA" id="RKGSNAW"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF3">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR RV1931C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="2">
        <location>
            <begin position="15"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="289" mass="31397" checksum="9A920894181DD12A" modified="2006-03-21" version="1">MANKTSAVADEPIEVLFALHPKFNLMDFAGPVEVLTSCLHDAKDPTSKAFEITLAGGEPQVLSEQGVIIGAQATWKEAHERLNDFDVLVVVGGNADEIIKQKAEPLDLITAYAELQKNDPSRERTLLSICTGSHFLAHQGILSGLAATTHPDEITKFENLCSHAVVRLLGEHTDVKEEARYVVNNLRFELGDEDENPYIRRKSDSGRRPSNARKGSMSFKGASRRESIARRAAMRLGGLRVITSGGVAAGMDAALYVASILVSEDSANEVARVMQLTWTKGIVMDGLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0S6</accession>
    <name>Q2H0S6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rRNA-processing protein FYV7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223834.1">
        <property type="nucleotide sequence ID" value="XM_001223833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0S6"/>
    <dbReference type="GeneID" id="4391590"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04620"/>
    <dbReference type="eggNOG" id="ENOG502SBYU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076390_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H0S6"/>
    <dbReference type="OMA" id="HPTRELM"/>
    <dbReference type="OrthoDB" id="2135053at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN FYV7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="28923" checksum="CDDB8CC9BE03C966" modified="2006-03-21" version="1">MPSKRPRDEDAAVAAVAPPTADDTRKLKKAKHGFRVGPENLPDGAWRRKVTKIKKDLITKAKVKKQYAKIKAEHQKQASAPTPEDHTKNNAEPTIHPDQEGEDSTEPAPAQIHPERQAMLDAPSSLSKPPAQRQQRQRQQQQHQPTDETEADPAQPHSQTDQPDNPRQKRKHRHHKPDYYTKELATAERAKQAAAERAAEAARREQERQRRVADRERYRRAMAKAKTPGRDGRVKIGRESRLLLERVQRVVGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0V5</accession>
    <name>Q2H0V5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_04591</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223805.1">
        <property type="nucleotide sequence ID" value="XM_001223804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0V5"/>
    <dbReference type="FunCoup" id="Q2H0V5">
        <property type="interactions" value="469"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H0V5"/>
    <dbReference type="GeneID" id="4392744"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04591"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_1"/>
    <dbReference type="InParanoid" id="Q2H0V5"/>
    <dbReference type="OMA" id="MADEVDH"/>
    <dbReference type="OrthoDB" id="6251714at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="INSADHFAMILY"/>
    </dbReference>
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        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ87972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="23877" checksum="F7481660EB8EAF0C" modified="2006-03-21" version="1">MAQRLPGQNHPYHGGLVRHRAELRARVRTHRPARPAPGADGAPHRPSARGRRADPCRVARAPEIAENDINVMFQTNVTGLINMTQAILPIFKARPEGGAGDIINIGSIAGREPYPGGSIYCATKAAVRAFSDSLRKELIDTRIRVMEVDPGQVETEFSVVRFYGDKSKADAVYAGCDPLTPEDIAEVVVFVAGRRQNVVIADTLIFPSHQAGAGTLHRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0W0</accession>
    <name>Q2H0W0_CHAGB</name>
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        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223800.1">
        <property type="nucleotide sequence ID" value="XM_001223799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0W0"/>
    <dbReference type="GeneID" id="4392192"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04586"/>
    <dbReference type="eggNOG" id="ENOG502QV7Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006057_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H0W0"/>
    <dbReference type="OMA" id="ERMNVTP"/>
    <dbReference type="OrthoDB" id="66726at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16616">
        <property type="entry name" value="mRING-HC-C4C4_Asi1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="590"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="894"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="986" mass="108238" checksum="5685805F31A05FB4" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H157</accession>
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        <recommendedName>
            <fullName evidence="4">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">CHGG_04489</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223703.1">
        <property type="nucleotide sequence ID" value="XM_001223702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H157"/>
    <dbReference type="FunCoup" id="Q2H157">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H157"/>
    <dbReference type="GeneID" id="4392698"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04489"/>
    <dbReference type="eggNOG" id="KOG1657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045277_7_3_1"/>
    <dbReference type="InParanoid" id="Q2H157"/>
    <dbReference type="OMA" id="PYNTNAI"/>
    <dbReference type="OrthoDB" id="636685at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23645">
        <property type="entry name" value="HFD_Dpb3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF54">
        <property type="entry name" value="CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="19"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="135"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ87870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="212" mass="23152" checksum="DB6A3653B2A3775E" modified="2006-03-21" version="1">MPYNTTAIPPRKEVTGQTQLPLTRVKKIIAVDPDIAVCSNNAAFVITLATEMFVQYLTGEAQNMTKLERKPRRNIQYKDMGKQNPLPFPSRLIPDEALANAVTHQDNLEFLEDIIPKTTSYKEVKGKAAAARARVSGEKSGKAATAAAEEDRPTEGMPNGKRPKSIMNGNAPSANGLTRVGVLSSDAIDPNDQLETEMRQAQQQDEDVDMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1B4</accession>
    <name>Q2H1B4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CoA-transferase family III</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001223645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1B4"/>
    <dbReference type="STRING" id="306901.Q2H1B4"/>
    <dbReference type="GeneID" id="4392559"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04432"/>
    <dbReference type="eggNOG" id="KOG3957">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033975_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H1B4"/>
    <dbReference type="OMA" id="IIAGPYC"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047369">
        <property type="term" value="F:succinate-hydroxymethylglutarate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1540.10:FF:000005">
        <property type="entry name" value="succinate--hydroxymethylglutarate CoA-transferase isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="42502" checksum="47D75E9D60ADCA61" modified="2006-03-21" version="1">MSRPYCTQILGDLGAEVIKIEHPVRGDDTRAWGPPYATYKAGSLHEGPGESAYFLAVNRNKKSLALSFQDPAGIEILHKLAAKCDILVENYIPGSLKKYGLDYETIHKINPALIYASITGYGQTGPYSQRPGYDVMVEAEFGLMHITGSRDGPPVKVGVAVTDLTTGLYTSNSIMAALLASARTGKGQHIDAALSDCQTVTLSNIASSCLISGEKDSGRWGTAHPSIVPYRSFKTKDGDVLFGGGNDKLFGILCDGLSRPEWKDHAKFQVNASRVAHRDELEAEIEAITVTKTTQEWLDTFEGKGMPYAAVNDVQGALAHAQTKARNMVIEVDHDECGPIKLLNTPIKYSESKPGIRSPPPTLGQHTDEILREHLGMGEAQVQVLKQKGVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1G6</accession>
    <name>Q2H1G6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223594.1">
        <property type="nucleotide sequence ID" value="XM_001223593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1G6"/>
    <dbReference type="STRING" id="306901.Q2H1G6"/>
    <dbReference type="GeneID" id="4393067"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04380"/>
    <dbReference type="eggNOG" id="ENOG502RFRV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032154_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H1G6"/>
    <dbReference type="OMA" id="HFLATCK"/>
    <dbReference type="OrthoDB" id="5279415at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="495" mass="56901" checksum="46E9004A3612F134" modified="2006-03-21" version="1">MSWDPDTSVIPGEERDQEEQAKAWYDEPTRARNRLLEAENLRLKKLLRENGISWDPRLTLDPDDLTRGSWSSPKRSRTRKSKGSMSLSPQNSHLPMLPVEIQLYILEYALTSKTPIIDPLSKSNRDTLSAAERTADNQIAIGFLATCKAYLIEGTRFLWNNNTFIFTSHVALRNFANLSLEHRKGIKYATFRIIARYYDDEERKHLAPYPSTADTYAKTINLKTTLRIKEENLARKGFRSYTWEQVVDFLDAMRPPFDPHHPKGQPRPRLLPGLETLRMDFVNFPDSFLSPGSGSFLHSFASHDLGCTLNELQLTGLPACDLGDELVSELSGMVKDEGLVLKSDATYVYSGNQLRQIEKPPKGQRLNRWSWMTSWDPKVVRSWKALADEYARSKNKPAAPQPSHAHHRHSHAGHHRMPPAPKEEGHPESPWKERRTLFKRVPRHKHSGERIWVEFDRLTGLEIDPLDYDEEDDEYDISDLVCPHCDVMHPPSGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2T3</accession>
    <name>Q2H2T3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223127.1">
        <property type="nucleotide sequence ID" value="XM_001223126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2T3"/>
    <dbReference type="GeneID" id="4392177"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03913"/>
    <dbReference type="HOGENOM" id="CLU_2108742_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2T3"/>
    <dbReference type="OrthoDB" id="10307099at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="115" mass="12608" checksum="37C867B773A06482" modified="2006-03-21" version="1">MPALRTQQPRKAAVGDPWTPVSPFSHTVGNCNLVVPRRLFSASPPICKTLNRHRDSTWRAPGCVTPLIRPSAESPERRARMTCMNRSGQSGRLYRKLLVQQQFAAAGNPGVACGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2U2</accession>
    <name>Q2H2U2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223118.1">
        <property type="nucleotide sequence ID" value="XM_001223117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2U2"/>
    <dbReference type="STRING" id="306901.Q2H2U2"/>
    <dbReference type="GeneID" id="4392394"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03904"/>
    <dbReference type="eggNOG" id="KOG1433">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119631_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2U2"/>
    <dbReference type="OMA" id="IESVCAF"/>
    <dbReference type="OrthoDB" id="5957327at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="154" mass="16933" checksum="C5E060C56EE38E6B" modified="2006-03-21" version="1">MQAERGAALVPAINASVWEQGMSTRIVLFRDWLGEGSETRGLHFAAIQKLNGKGIGPSIESVCAFEVDQYDDTQHSRTLTSTLAPKRKLGDTDFEVADSDDEGYGWDDDEELPPMPSQWQGSEDLLLIRKPGSDDDNEEEDHSVDAHESGNEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H333</accession>
    <name>Q2H333_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_03813</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AVL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223027.1">
        <property type="nucleotide sequence ID" value="XM_001223026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H333"/>
    <dbReference type="FunCoup" id="Q2H333">
        <property type="interactions" value="206"/>
    </dbReference>
    <dbReference type="GeneID" id="4392980"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03813"/>
    <dbReference type="eggNOG" id="KOG3823">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_332322_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H333"/>
    <dbReference type="OrthoDB" id="26278at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="19"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="491"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="634"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="736"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="564"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="586"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="667"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="691"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="708"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="742"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="775"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="790"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ87194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="861" mass="94704" checksum="7648A4B0C465F7AD" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3K3</accession>
    <name>Q2H3K3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_06762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222857.1">
        <property type="nucleotide sequence ID" value="XM_001222856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3K3"/>
    <dbReference type="STRING" id="306901.Q2H3K3"/>
    <dbReference type="GeneID" id="4390096"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06762"/>
    <dbReference type="eggNOG" id="ENOG502T6RH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1447513_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3K3"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ90143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="187" mass="21095" checksum="C413D49EF583C311" modified="2006-03-21" version="1">MYHFTLPRSRLCPQQSGSKGHAEMPEMIFSDSASLIVLRDATSYRSVASDALSKLSWVFGFDKQLRGSTVYGRAWRNNLKKSRECEEASRLIVPPPEEQQQTGESLRGREFNIILLGISGCSKTTLLKQMLQIIFSNMCELAGALGDELDSEDGTFSPQVQPCSELWSDAEWREWLSRSPDRNIQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3M9</accession>
    <name>Q2H3M9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222831.1">
        <property type="nucleotide sequence ID" value="XM_001222830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3M9"/>
    <dbReference type="GeneID" id="4390989"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06736"/>
    <dbReference type="HOGENOM" id="CLU_1147081_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3M9"/>
    <dbReference type="OrthoDB" id="10326047at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="242" mass="25989" checksum="B3D02F067DE9065E" modified="2006-03-21" version="1">MTSSLLPHTTVGGKTPVKGVTGKKRRVMMVLVDYHGWGGIPRMLHQPHESGVARNSGDSSAVENAKECLFGVVIRSGNAEIARKKEGRATSRSGGAEKKRARCELRAKLSGRVVNKRKQMRLKEAGTGVLSRREQVGPNLIHADLGGRLDGTCPRVGRGLQIPQQSYQVLEKSWVPGLEPLQFSPNPIAGDDQISQGTSNGRDLVVGADSSASQVDEARSDQREISAGEGGGEEQCEARFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4G9</accession>
    <name>Q2H4G9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF7728 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_06446</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222541.1">
        <property type="nucleotide sequence ID" value="XM_001222540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4G9"/>
    <dbReference type="GeneID" id="4391472"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06446"/>
    <dbReference type="eggNOG" id="ENOG502SC3G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038083_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H4G9"/>
    <dbReference type="OMA" id="CRGKPKC"/>
    <dbReference type="OrthoDB" id="5409353at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056145">
        <property type="entry name" value="DUF7728"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40622">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40622:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24854">
        <property type="entry name" value="DUF7728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209264" description="DUF7728 domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7728" evidence="4">
        <location>
            <begin position="49"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ89827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="385" mass="42447" checksum="7C591B59203D6AA8" modified="2006-03-21" version="1">MLLKPLTLVAGLLAVPAARAFLVPPEVSDTDIQVANTIDSIASQINEIHVDVQCPGCPVLLRNRRGKTVQFKTKFPSHLELTFSVDHLADHDRLLLNGVELYPAHEALTTALKAPQVVDRKTKEKTKEKRHHPDGERHKGRYRVYPQPQQLSFGLKVMPATKDAKTELELVEIEFQIIAVGVAFIDGIPGVKVSLVKDSEGRLLISKVEKGEANTFVKELPGGDANECTTALCRWISAAREKLKSFKGHCSNKGGAEPSVSGEASHPHSHPHHPAAGHGHQEHRWGKLLKHMASHILLPVLIGIVAGVSVSLIGMAVGTVLISLWRVFFRRRHHSGSSGHRRRHSHHKTPRKEVVLVEEEKAGLMVNQDAPPSYEEQETVKTSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4V4</accession>
    <name>Q2H4V4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Choline kinase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_06311</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222406.1">
        <property type="nucleotide sequence ID" value="XM_001222405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4V4"/>
    <dbReference type="FunCoup" id="Q2H4V4">
        <property type="interactions" value="334"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H4V4"/>
    <dbReference type="GeneID" id="4390506"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06311"/>
    <dbReference type="eggNOG" id="KOG2686">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012712_4_0_1"/>
    <dbReference type="InParanoid" id="Q2H4V4"/>
    <dbReference type="OMA" id="CEQVINW"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004103">
        <property type="term" value="F:choline kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007521">
        <property type="entry name" value="Choline_kin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF93">
        <property type="entry name" value="RE24176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04428">
        <property type="entry name" value="Choline_kin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Choline kinase N-terminal" evidence="3">
        <location>
            <begin position="283"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="565"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="727"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ89692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="803" mass="88801" checksum="10CB41EA0C604DCD" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H500</accession>
    <name>Q2H500_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_06265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222360.1">
        <property type="nucleotide sequence ID" value="XM_001222359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H500"/>
    <dbReference type="STRING" id="306901.Q2H500"/>
    <dbReference type="GeneID" id="4391218"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06265"/>
    <dbReference type="eggNOG" id="ENOG502SANM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021705_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H500"/>
    <dbReference type="OMA" id="ADFFYVF"/>
    <dbReference type="OrthoDB" id="5410752at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="414"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="497" mass="58521" checksum="A7D966EE1A6495B0" modified="2006-03-21" version="1">MSRSRVDFDEREFREPMRRTVVRDYDDVEIRRERERVNDRIPAFMREENRRVEPGQMVLRQREIETVERPRQRSPSPAGTRITQRVVHRTRSVSPPPRRLEEDIHFRRVAREPSRGPGERIRFVPSRSSSPDTEVRERIRITEREKERAPSPAPRPPTPKVIKGPTVEREVITHYRDIDHGVVAVRPPSPPPPPVRHRDTEIDIYTSRGQTDIDIHKHSHTHSRGRSISRERPSRRAAQTWEDDVTVHADRKHLHVDIERRRSVSRTRRAQSAAPPTIDYGDEEYEITNKLDSRGKMGEAWNGITKDWAIIDVPPGTERVRMDGAGGASAEVTWQKYSGVRRAKFIPEREDKGSAVSSTTSFTELRAPERERRLSVHVVDKDRGVSRERDVEVEKVTDRRITVRGSTPPARRPETWTEITKDLVCREAIQDLKYEFEETEYFYYIVEYLSYEDVLQLVKVSDRIRAARKERAREIAYERDWRENYDHRDNTHHHGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5Z9</accession>
    <name>Q2H5Z9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_05916</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222011.1">
        <property type="nucleotide sequence ID" value="XM_001222010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5Z9"/>
    <dbReference type="FunCoup" id="Q2H5Z9">
        <property type="interactions" value="867"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H5Z9"/>
    <dbReference type="GeneID" id="4391253"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05916"/>
    <dbReference type="eggNOG" id="KOG2884">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033293_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H5Z9"/>
    <dbReference type="OMA" id="QMSMQDQ"/>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01452">
        <property type="entry name" value="VWA_26S_proteasome_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3990:FF:000001">
        <property type="entry name" value="26S proteasome regulatory subunit S5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="5"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="262"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ89297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="292" mass="31181" checksum="228D677CC8CD2111" modified="2006-03-21" version="1">MVLEAVMIVVDNSESSRNGDYPATRYDAQSDAVNIIFQNVVQGNPESSVGLMSMGGKGPEVLATLTTDQGKILEGLHQTKKKIRGHAHVSTGIQIASLALKHRQNKSQRARIVVFVCSPIEEGERELVTLAKKMKKFSISVDFVLFGDMDEENQAKLEAFNREIKGTTDSSHLVVIPPSSKLLSDQLISTPIMLGEAAPSGGGGAGAEAGGGASEDFPFGVDPTQDPELALALRMSMEEEKARQEKKAREEGEAANKGGLESVKEEGESAPLLDKDGQPGGSKKDDDKMDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H600</accession>
    <name>Q2H600_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_05915</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222010.1">
        <property type="nucleotide sequence ID" value="XM_001222009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H600"/>
    <dbReference type="FunCoup" id="Q2H600">
        <property type="interactions" value="288"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H600"/>
    <dbReference type="GeneID" id="4391252"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05915"/>
    <dbReference type="eggNOG" id="KOG3369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053380_2_1_1"/>
    <dbReference type="InParanoid" id="Q2H600"/>
    <dbReference type="OMA" id="NKTFHEG"/>
    <dbReference type="OrthoDB" id="246406at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14856">
        <property type="entry name" value="TRAPPC4_synbindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000007">
        <property type="entry name" value="Putative sybindin-like family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF15">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ89296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="160" mass="18031" checksum="17AA43C9F9C8AE74" modified="2006-03-21" version="1">MATTVFALIIINKAGGLIYNRSFHEGGLNTLSTNDYLVLAGTFHGVHAITARLNPLKAVNNRTSTSSGGGAPFTRPDPPSGLEVLETENFRMQCFTTMTGIKFLLFTDTTQVNVDRTIQRVYEMYTDYVLKNPFYQLEMPVRCDMFDRKLGSHIREINNR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2025-06-18" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H679</accession>
    <name>MRH4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent RNA helicase MRH4, mitochondrial</fullName>
            <ecNumber>3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">MRH4</name>
        <name type="ORF">CHGG_05836</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in mitochondrial RNA metabolism. Required for maintenance of mitochondrial DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. MRH4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221931.1">
        <property type="nucleotide sequence ID" value="XM_001221930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H679"/>
    <dbReference type="SMR" id="Q2H679"/>
    <dbReference type="FunCoup" id="Q2H679">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H679"/>
    <dbReference type="GeneID" id="4390031"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05836"/>
    <dbReference type="eggNOG" id="KOG0335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_18_0_1"/>
    <dbReference type="InParanoid" id="Q2H679"/>
    <dbReference type="OMA" id="HSTIDFI"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000256052" description="ATP-dependent RNA helicase MRH4, mitochondrial">
        <location>
            <begin position="36"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="194"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="439"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="38"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif">
        <location>
            <begin position="164"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box">
        <location>
            <begin position="334"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="207"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="576" mass="64293" checksum="CBB9390A2AD66B0D" modified="2006-03-21" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6C0</accession>
    <name>Q2H6C0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_05795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221890.1">
        <property type="nucleotide sequence ID" value="XM_001221889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6C0"/>
    <dbReference type="GeneID" id="4391172"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05795"/>
    <dbReference type="HOGENOM" id="CLU_2399463_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6C0"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="93" mass="9772" checksum="19C6072FF9B8B3E7" modified="2006-03-21" version="1">MTAGFRSSEPCAVVICGVVRFVLPTAIRVRDGGLVVGGWEGARSEPSTGGKVPWGGGEATTWNSLMIHGPASVYFLRQALARQRTEWGTPVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6R3</accession>
    <name>Q2H6R3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_05652</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRDE2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221747.1">
        <property type="nucleotide sequence ID" value="XM_001221746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6R3"/>
    <dbReference type="STRING" id="306901.Q2H6R3"/>
    <dbReference type="GeneID" id="4390269"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05652"/>
    <dbReference type="eggNOG" id="KOG1972">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007550_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6R3"/>
    <dbReference type="OMA" id="LYSEMAY"/>
    <dbReference type="OrthoDB" id="297219at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902369">
        <property type="term" value="P:negative regulation of RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013633">
        <property type="entry name" value="NRDE-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471:SF0">
        <property type="entry name" value="NUCLEAR EXOSOME REGULATOR NRDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08424">
        <property type="entry name" value="NRDE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="825"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="835"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ89033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="999" mass="110021" checksum="82BAED8B5F94482C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6R7</accession>
    <name>Q2H6R7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartyl aminopeptidase</fullName>
            <ecNumber evidence="4">3.4.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_05648</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.</text>
            <dbReference type="EC" id="3.4.11.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.21" evidence="4"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221743.1">
        <property type="nucleotide sequence ID" value="XM_001221742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6R7"/>
    <dbReference type="FunCoup" id="Q2H6R7">
        <property type="interactions" value="568"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H6R7"/>
    <dbReference type="GeneID" id="4390919"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05648"/>
    <dbReference type="eggNOG" id="KOG2596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019532_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H6R7"/>
    <dbReference type="OMA" id="GPILKVN"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002759">
        <property type="entry name" value="PRK02813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF3">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ89029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="481" mass="51631" checksum="387D38E7B8E0337F" modified="2006-03-21" version="1">MAPSKSALEFLDFVNASPTPYHAVAEAAALLDAAGFTKIQERDNWASIVKPGGKYYTTRNSSSVVAFAVGAQWKSGNPIAMVGAHTDSPCLRIKPNSKRTANGYLQVGVETYGGGIWHSWFDRDLSVAGRVLVREGDGEGKFVQKLVKVDKPILRIPTLAIHLHRQTNFDPNKEDEMLPIAGLAAAELNKTAEAETGSEGDFQPLAAMPERHHPAFLSLVAEHAGVNVSQIVDFELILYDTQKSCLGGLNDEFILSARLDNLNMTFCSVKGIISSVESTPLDKDTTIRLVACFDHEEIGSLSAHGADSNLLPAILRRLSVLPGNDTTTTASDLAASTAFEQTCAASFLLSADMAHAVHPNYAAKYERQHTPAINAGPVIKINANQRYATNSPGIVLVQEVARAARVPLQLFVVKNDSPCGSTIGPMLSAKLGLRTLDMGNPQLSMHSIREMGGAGDVESAVRLFAAFLGRFGELEGRILVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6T4</accession>
    <name>Q2H6T4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_05631</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIAS family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221726.1">
        <property type="nucleotide sequence ID" value="XM_001221725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6T4"/>
    <dbReference type="FunCoup" id="Q2H6T4">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H6T4"/>
    <dbReference type="GeneID" id="4390085"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05631"/>
    <dbReference type="eggNOG" id="KOG2169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020537_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H6T4"/>
    <dbReference type="OMA" id="SYAMASY"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16792">
        <property type="entry name" value="SP-RING_Siz-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.780">
        <property type="entry name" value="PINIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023321">
        <property type="entry name" value="PINIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038654">
        <property type="entry name" value="PINIT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031141">
        <property type="entry name" value="SIZ1/2_SP-RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14324">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51466">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAP" evidence="10">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="PINIT" evidence="12">
        <location>
            <begin position="115"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="SP-RING-type" evidence="11">
        <location>
            <begin position="312"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="59"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="396"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="396"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="417"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ89012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="51286" checksum="3AA7055F90EBB9D9" modified="2006-03-21" version="1">MDDKSAEVQSLVRTIQVPAISKAILQSICAVNGIPKTGNKSELQRRIINLSQVSLRSQPIQQPSYYQAPRPQTPPSYAMGSYNQPGYGSLNGLRSQNPPSVAYQSQPPTTGAAGRLRPNAGLVAPAITYKPSPFYELKYQIGDVKTLEGVFGSPHFSAPLRPLVANWNSVMAAHRNSERVSIKVQDHPALQLCLTDRTMRVMVLCTAGNVGVQEISFPYQCELKVNGGDIKANLRGLKNKPGSTRPVDITDSLRLRPASYTNNVELTYALTQKKFYLVLIVCKSVPIEALVSQIQKKIRKESVVAEITKKASDPDVVAMSQNLSLKCPLSYMRLNLPCRGVSCNHIQCFDATSYLQLQEQGPQWLCPICNKPAPFEQLAIDDYLDDDDIVVSQVTKTTGRASTGPSQAAASTPHLATPTSVGSRDTSAAPRSSKKRPAPEVIDLTLSDDDEPPRPVKRSNHGNGYSTVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7V4</accession>
    <name>Q2H7V4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230216.1">
        <property type="nucleotide sequence ID" value="XM_001230215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7V4"/>
    <dbReference type="STRING" id="306901.Q2H7V4"/>
    <dbReference type="GeneID" id="4389795"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03700"/>
    <dbReference type="eggNOG" id="KOG0351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_463069_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7V4"/>
    <dbReference type="OrthoDB" id="5244177at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="589" mass="65695" checksum="ED8C2365BD5540E9" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H821</accession>
    <name>Q2H821_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_03633</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230149.1">
        <property type="nucleotide sequence ID" value="XM_001230148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H821"/>
    <dbReference type="STRING" id="306901.Q2H821"/>
    <dbReference type="GeneID" id="4388928"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03633"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_5_1"/>
    <dbReference type="InParanoid" id="Q2H821"/>
    <dbReference type="OMA" id="DWKRQAW"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="16"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ91698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="345" mass="35712" checksum="2B0C52710CE8A368" modified="2006-03-21" version="1">MSQPTANLAAVLPSPGAKLVIEERPIPTPGPDELVVRNHAIALNPIDWKRIDLNIALPTYPAIIGSDVSGIVTAVGSNVTAFQPGDRVLAAGPGMGTGNPDHAAYQTYTVVPASIAAKLPDALAFRDAAAAVTSTSTPALALFDVLGLPAPESAAKPPTNTGILVWGAASSMGTGTVQLARLAGLKVFATASPQHHARVRALGATAVVDYRSPTAVEDLVAAAKEAGVNVALAVDSISTDDTLPLVVDFLAKFDGPKKVAHLLQWPEHVAKPADVEAAWVAGFRIWSARKDLSEMVFNRLLTGWLEKGEVVPGPVRVIDGGLGGLQTALDVLRKGVSGEKLVVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H832</accession>
    <name>Q2H832_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alcohol dehydrogenase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230138.1">
        <property type="nucleotide sequence ID" value="XM_001230137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H832"/>
    <dbReference type="STRING" id="306901.Q2H832"/>
    <dbReference type="GeneID" id="4389257"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03622"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_19_5_1"/>
    <dbReference type="InParanoid" id="Q2H832"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="2">
        <location>
            <begin position="36"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="225" mass="23819" checksum="5F20AFD4D1DD9487" modified="2006-03-21" version="1">MARRLVGDGKGGGGDGVRKGEGMKGMRVLVNGASGGVGSVLVQICKGMGAEVVGVCSGASEGLVKGLGVDEVVDYRVHNPLEAHLAERFGEQQFDAVLDCVGSQSLYMNSPRYLKPEGKFINIVGGWSQGVVPFIRNKLRPCLLGGTPRSYDLFLLSASGETAREAAAFVEQGIIKQAVIDSVFPMEEAIEITKDELGYGKASVRANYNWFITLSAGIVVLVEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8B2</accession>
    <name>Q2H8B2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230058.1">
        <property type="nucleotide sequence ID" value="XM_001230057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8B2"/>
    <dbReference type="STRING" id="306901.Q2H8B2"/>
    <dbReference type="GeneID" id="4388450"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03542"/>
    <dbReference type="eggNOG" id="ENOG502SPDA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064362_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8B2"/>
    <dbReference type="OMA" id="RQEPPQM"/>
    <dbReference type="OrthoDB" id="4151352at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="121"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="350" mass="38097" checksum="986275DFC62E2F47" modified="2006-03-21" version="1">MTRTRRPPRRSNRDMRFAQGPEGTSRVSDPPSSEPQGGGYRLIAAQQPSTTLGPGPIRYPPLPAAPPPPSAHTVPPAPVQTHFETSTVDEGDGTAEVAGQELIGDETATLAEYPYSIYNHGTWTADDDKTLIQARSRGQNWADLQRTHFPTKTANACRKRYERLVERRGIHDYSGRRLEMVASEYMTMRKDVWSGLADRVGMKWEVVEALCMGTGLRTIQSNARSYTNRARRDNRISQKTREAQAEVVTSTGSVGLPLPLLPVGSEFGTAFTNHAVEPDRSSAVADRSMPPPPFFPTSGPPPSTRLPPMVLAPQVPFRGYPDGNARLMSGPANTGAPAPEPPPGTGPPIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8F8</accession>
    <name>Q2H8F8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">O-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_03496</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230012.1">
        <property type="nucleotide sequence ID" value="XM_001230011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8F8"/>
    <dbReference type="STRING" id="306901.Q2H8F8"/>
    <dbReference type="GeneID" id="4389004"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03496"/>
    <dbReference type="eggNOG" id="KOG1663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067676_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H8F8"/>
    <dbReference type="OMA" id="WHEATVG"/>
    <dbReference type="OrthoDB" id="10251242at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050362">
        <property type="entry name" value="Cation-dep_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF14">
        <property type="entry name" value="CAFFEOYL-COA O-METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
        <property type="entry name" value="O-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ91561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19516" checksum="8647757140BE46D9" modified="2006-03-21" version="1">MLTSVLSFTPEQAATVTEYCTESSEDVSPNLKELWDYTVSEFDDADKMSSPLQSATFKFLAELLRPRRILEIGCYTGYSALTWHEATVGTGAEIISLELDPKMIAASKRTFSRYDIEDRVQLIEGPAEESIKKLTGSFDLIFVDANKDGYETYVKQILDQHLLTPGGLLIGDNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8Y3</accession>
    <name>Q2H8Y3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Guanine nucleotide-binding protein alpha-1 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_03321</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229837.1">
        <property type="nucleotide sequence ID" value="XM_001229836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8Y3"/>
    <dbReference type="FunCoup" id="Q2H8Y3">
        <property type="interactions" value="418"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H8Y3"/>
    <dbReference type="GeneID" id="4389569"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03321"/>
    <dbReference type="eggNOG" id="KOG0082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014184_6_0_1"/>
    <dbReference type="InParanoid" id="Q2H8Y3"/>
    <dbReference type="OMA" id="QVIWADA"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000001">
        <property type="entry name" value="Guanine nucleotide-binding protein G(I) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000051">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="150"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="175"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="269"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ91386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="353" mass="40738" checksum="24FEA920DDC2F83A" modified="2006-03-21" version="1">MGCGMSTEEKEGKARNEEIENQLKKDRMQQRNEIKVLLLGAGESGKSTILKQMKLINEGGYSRDERESFKEIIFSNTVQSMRVILEAMESLELPLADSRMEYHVQTIFMQPAQIEGDVLPPEVGNAIEALWKDAGVQSCFKRSREYQLNDSARYYFDNIARIAAPDYMPNDQDVLRSRVKTTGITETTFIIGELTYRMFDVGGQRSERKKWIHCFENVTTILFLVAISEYDQLLFEDETVNRMQEALTLFDSICNSRWFIKTSIILFLNKIDRFKEKLPVSPMNNYFPDYEGGDDYGAACDYILNRFVSLNQHESKQIYTHFTCATDTTQIRFVMAAVNDIIIQENLRLCGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9T0</accession>
    <name>Q2H9T0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_03024</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229540.1">
        <property type="nucleotide sequence ID" value="XM_001229539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9T0"/>
    <dbReference type="FunCoup" id="Q2H9T0">
        <property type="interactions" value="332"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H9T0"/>
    <dbReference type="GeneID" id="4388537"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03024"/>
    <dbReference type="eggNOG" id="KOG1965">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005912_5_2_1"/>
    <dbReference type="InParanoid" id="Q2H9T0"/>
    <dbReference type="OMA" id="FTYVRRF"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="353"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="46"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="496"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="524"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="601"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ91089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="677" mass="72883" checksum="1A19467B3FF67131" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9V1</accession>
    <name>Q2H9V1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229519.1">
        <property type="nucleotide sequence ID" value="XM_001229518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9V1"/>
    <dbReference type="GeneID" id="4388675"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03003"/>
    <dbReference type="HOGENOM" id="CLU_2739802_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9V1"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="71" mass="7918" checksum="2808237F27EC5897" modified="2006-03-21" version="1">MPPPSSDDLHPPSHQSSGEKPLRSAIDVVEASSRRRPQPASCYLTVHKVQHLAKYGLSYAEENDPHMKKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HB81</accession>
    <name>Q2HB81_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NDT80 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_02523</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229039.1">
        <property type="nucleotide sequence ID" value="XM_001229038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HB81"/>
    <dbReference type="GeneID" id="4389224"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02523"/>
    <dbReference type="eggNOG" id="ENOG502SAHY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019835_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HB81"/>
    <dbReference type="OMA" id="RTQDKHT"/>
    <dbReference type="OrthoDB" id="4117572at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052605">
        <property type="entry name" value="Fungal_trans_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR VIB-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NDT80" evidence="4">
        <location>
            <begin position="98"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="2">
        <location>
            <begin position="98"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="229"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="387"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="504"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="394"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="546"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="596"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="639"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="682"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ90588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="703" mass="75800" checksum="82C8735B583ED0C9" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBD8</accession>
    <name>Q2HBD8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Non-haem dioxygenase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228982.1">
        <property type="nucleotide sequence ID" value="XM_001228981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBD8"/>
    <dbReference type="STRING" id="306901.Q2HBD8"/>
    <dbReference type="GeneID" id="4388779"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02466"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1015641_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HBD8"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="1">
        <location>
            <begin position="39"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="274" mass="29268" checksum="D45D1400489FCF44" modified="2006-03-21" version="1">MGKIANIPIIDISEGDQTQVAQDLVEAAIEHGFQAPDIAQSKRLFEAPLSEKQACTIQKNNRGWSGMNYETLDPANQRVGDFKEAFNFGDFLHHRAQQPLPPSIAADEPRISAFRDLCYQLSLKLTTLLGHGLADHVGARAGGAAWRGGGCGAAGVGQCGGFVVVLDGGPVEEYGASGCFSEGEGEEGGDGVGVDGEGDGAAMRYSIAYFCHPFGGTELKPVPSERVRAYKGGLAEGNPYAERRVMTADEHLKMRLKASYAQLYEEKDKGKEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HC99</accession>
    <name>Q2HC99_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bifunctional polynucleotide phosphatase/kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_02155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228671.1">
        <property type="nucleotide sequence ID" value="XM_001228670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HC99"/>
    <dbReference type="STRING" id="306901.Q2HC99"/>
    <dbReference type="GeneID" id="4389333"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02155"/>
    <dbReference type="eggNOG" id="KOG2134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014938_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HC99"/>
    <dbReference type="OMA" id="LAHNINI"/>
    <dbReference type="OrthoDB" id="19045at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ90220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="34760" checksum="7F5C635CD56E1255" modified="2006-03-21" version="1">MPIRQRSRLRPNGRRSPHSIWYRVVIFTNQGGLTLHPDPKSKGPKSAKNRVPGFKQKCSAVLSQLDIPLTLYAATGKDIYRKPRPGMWTEMKEDYDLSESEIDHENSVFVGDAGGRIAEPKGPGAAGKDFSCSDRNLAHNINIKYQTPEEFFLGEKPRDFARDFDVANFPYTDEEKDNEAWATKSNDQDIVLFVGFPGAGKSTFYWKYLEPLNYERVNQDTLKSKDKCFKTAADLLGKGESIVVDNTNADVDTRSQWIALARKHKVPIRCFWFQTPLQLCEHNAAARALNEKVHGDISAHGARRMHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCR0</accession>
    <name>Q2HCR0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_01994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221215.1">
        <property type="nucleotide sequence ID" value="XM_001221214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCR0"/>
    <dbReference type="GeneID" id="4386614"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01994"/>
    <dbReference type="HOGENOM" id="CLU_2757565_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCR0"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ93759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="70" mass="7753" checksum="A396D9064F14F034" modified="2006-03-21" version="1">MSKDASNHGFCLVDMERMSNTWPTPSCSESKMASRISIQYSSRATSSMAIKDPSSPADRYRAMRTEANVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HD27</accession>
    <name>Q2HD27_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_01877</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221098.1">
        <property type="nucleotide sequence ID" value="XM_001221097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HD27"/>
    <dbReference type="FunCoup" id="Q2HD27">
        <property type="interactions" value="417"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HD27"/>
    <dbReference type="GeneID" id="4386221"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01877"/>
    <dbReference type="eggNOG" id="KOG0236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_8_1_1"/>
    <dbReference type="InParanoid" id="Q2HD27"/>
    <dbReference type="OMA" id="TLYQFWR"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000024">
        <property type="entry name" value="Sulfate permease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sulfate_transp"/>
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    </dbReference>
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        <property type="entry name" value="SpoIIaa-like"/>
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    </dbReference>
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        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
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        <location>
            <begin position="553"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="591"/>
            <end position="630"/>
        </location>
    </feature>
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            <end position="805"/>
        </location>
    </feature>
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        <location>
            <begin position="867"/>
            <end position="893"/>
        </location>
    </feature>
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        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ93642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="893" mass="95120" checksum="B6CC03EF44F2256B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDI9</accession>
    <name>Q2HDI9_CHAGB</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CHGG_01715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ93480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001220935.1"/>
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    <dbReference type="GeneID" id="4386941"/>
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    <dbReference type="eggNOG" id="KOG1818">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_037982_1_1_1"/>
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    <dbReference type="OrthoDB" id="5407799at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="306"/>
        </location>
    </feature>
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        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
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        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
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        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ93480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="306" mass="32092" checksum="FFA96B4D6C599F49" modified="2006-03-21" version="1">MKPSRPSDQSLLDRLNALKSTGVTLDKPANIAILPVADAQPSSKEDALAARLRILRSQSSSSSRDGASAGAPPPGSPPPKEGGTKRVSPAPEGPKDHSQKRPPIRSAEFEAADEEALDELLGALGDEEFDLAADEDAVPPPDLDPRDEARRVSDLLETLGKKAGGPASNGPSNTEGDDDDDNSDGEQMTRDVDTLLSQIRDEINSLPPPSTATPQDGDEEAPITLPTVPSQLVDPAPDPHGDEDALEQDLAARMASLRGLGPPTSASDPLGLPSAPTFRPQDRTGNTGEQRLGGSSKYTDADQKTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDY0</accession>
    <name>Q2HDY0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_01574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001220794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDY0"/>
    <dbReference type="GeneID" id="4387245"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01574"/>
    <dbReference type="eggNOG" id="ENOG502R6UB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110370_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HDY0"/>
    <dbReference type="OMA" id="TTPCHKN"/>
    <dbReference type="OrthoDB" id="5239982at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ93339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18509" checksum="45835CF40FB8AB82" modified="2006-03-21" version="1">MATVQLAVASPTYKIPLALSRVAHKGQFCTYPEEFVVKNFRTWTPEGGNNRSATVEFDYTDDSVMPAIETKCHFNETSVNVGPQDLAARYACENSLVEFIWNERELTMVERACPFETENRPFEAAGWVTPNMKCTLSTRNGTADGQACSSSPSVLSAVFNSLEPRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HE12</accession>
    <name>Q2HE12_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Terpene cyclase/mutase family member</fullName>
            <ecNumber evidence="7">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_01542</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="7"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220763.1">
        <property type="nucleotide sequence ID" value="XM_001220762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HE12"/>
    <dbReference type="STRING" id="306901.Q2HE12"/>
    <dbReference type="GeneID" id="4388019"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01542"/>
    <dbReference type="eggNOG" id="KOG0497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009074_2_1_1"/>
    <dbReference type="InParanoid" id="Q2HE12"/>
    <dbReference type="OMA" id="YRYRHIS"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000250">
        <property type="term" value="F:lanosterol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000002">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000003">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF20">
        <property type="entry name" value="LANOSTEROL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="10">
        <location>
            <begin position="19"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase C-terminal" evidence="9">
        <location>
            <begin position="323"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ93307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="662" mass="74827" checksum="EA8E70A092E35C40" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HE73</accession>
    <name>Q2HE73_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_01481</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family. PalF/RIM8 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220702.1">
        <property type="nucleotide sequence ID" value="XM_001220701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HE73"/>
    <dbReference type="FunCoup" id="Q2HE73">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HE73"/>
    <dbReference type="GeneID" id="4386192"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01481"/>
    <dbReference type="eggNOG" id="ENOG502QTQN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006001_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HE73"/>
    <dbReference type="OMA" id="CLHGYAK"/>
    <dbReference type="OrthoDB" id="7785529at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF161">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALF_RIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="335"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="585"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="634"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="649"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="738"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="769"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ93246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="836" mass="89766" checksum="69C34148E1B3E21B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEG4</accession>
    <name>Q2HEG4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_01390</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="4"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220611.1">
        <property type="nucleotide sequence ID" value="XM_001220610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEG4"/>
    <dbReference type="FunCoup" id="Q2HEG4">
        <property type="interactions" value="521"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HEG4"/>
    <dbReference type="GeneID" id="4387062"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01390"/>
    <dbReference type="eggNOG" id="KOG1390">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HEG4"/>
    <dbReference type="OMA" id="ICPSIAI"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF165">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="11">
        <location>
            <begin position="7"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="12">
        <location>
            <begin position="276"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="9">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ93155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="399" mass="41438" checksum="493F0B19583C207E" modified="2006-03-21" version="1">MAGLPSVYIVSAARTPVGSFLGSLSSLTATQLGSHAIKSAVERVPEIKPEDVEEVFYGNVLSANLGQAPARQCAINAGLSESVVCTTINKVCASGLKAIILGAQTIMTGNASIVVAGGTESMSNTPHYLPNLRTGVKYGDASLVDGVQKDGLRDAYGKQELMGMQGELCSEEHGLTREMQDEYAINTYKKAQAATEAGVFTEIAPIEVSGGRGKPPIKVDRDEEVKNLNVDKLKSVRPVFIPNGGTVTAANAAPINDGAAAVVLVSEAKLKELGIKPIAKILGWADAARDPPRFTIAPALAIPKAIKHAGLTEKDVDYYEINEAFSVVALANIKLLNLDAEKVNVFGGSVAIGHPLGASGARIVTTLTSVLREKKGKIGVAGICNGGGGASALVIENLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HF65</accession>
    <name>Q2HF65_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_01139</name>
    </gene>
    <organism evidence="4 5">
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                <person name="Untereiner W.A."/>
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        <source>
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</entry>
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        <source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
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    </evidence>
    <sequence length="1863" mass="203367" checksum="36454BDCFA016E8F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFP5</accession>
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                <person name="Untereiner W.A."/>
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            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
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        <location>
            <begin position="62"/>
            <end position="227"/>
        </location>
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        <location>
            <begin position="833"/>
            <end position="1199"/>
        </location>
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        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
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        <location>
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            <end position="316"/>
        </location>
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            <end position="484"/>
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            <end position="524"/>
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    </evidence>
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        </source>
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    <sequence length="1199" mass="133712" checksum="BB4999AF15A8B356" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFT9</accession>
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="18">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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        <subcellularLocation>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="VEZATIN"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Vezatin"/>
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    </dbReference>
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    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin-binding" evidence="16">
        <location>
            <begin position="149"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="413"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="556"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAQ92680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="608" mass="67646" checksum="7587D775364E2CB3" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGA6</accession>
    <name>Q2HGA6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219969.1">
        <property type="nucleotide sequence ID" value="XM_001219968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGA6"/>
    <dbReference type="STRING" id="306901.Q2HGA6"/>
    <dbReference type="GeneID" id="4386900"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00748"/>
    <dbReference type="eggNOG" id="ENOG502SUY3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1102667_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGA6"/>
    <dbReference type="OMA" id="PLRIDHE"/>
    <dbReference type="OrthoDB" id="3944545at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="252" mass="28534" checksum="96510F5AB39A5CF2" modified="2006-03-21" version="1">MVFPQLSTAGKRLFWRLNGPLEGAIEVSPSEYYEPGALMEPYFGPDGSLHPVSQASLVEPPVSSDTVRIRCVNERERVWVEEHSRCHDGPLYQGYPRRLGPRPDDETFDPKIYVLECCGQKRPWSYDTYLQVAAQGEFLTVHEYVSAVHPWLMAMRDTLLDALGKTNYQPKWPPETKLAVVDLGPGPLRIDHEDGWASWHEKPPLPRPASDQPQLSDGEWQRGAMARAMARSAAIIRAREEAARAAEMEKEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2025-06-18" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGF7</accession>
    <name>DBP5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent RNA helicase DBP5</fullName>
            <ecNumber>3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DBP5</name>
        <name type="ORF">CHGG_00697</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. May also be involved in early transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with the nuclear pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location>Nucleus</location>
            <location>Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="1">Nuclear pore complex cytoplasmic fibrils.</text>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219918.1">
        <property type="nucleotide sequence ID" value="XM_001219917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGF7"/>
    <dbReference type="SMR" id="Q2HGF7"/>
    <dbReference type="FunCoup" id="Q2HGF7">
        <property type="interactions" value="686"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HGF7"/>
    <dbReference type="GeneID" id="4386723"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00697"/>
    <dbReference type="eggNOG" id="KOG0332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HGF7"/>
    <dbReference type="OMA" id="IAAETRW"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17963">
        <property type="entry name" value="DEADc_DDX19_DDX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0509">mRNA transport</keyword>
    <keyword id="KW-0906">Nuclear pore complex</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000256014" description="ATP-dependent RNA helicase DBP5">
        <location>
            <begin position="1"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="105"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="285"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box">
        <location>
            <begin position="221"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="118"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="479" mass="52469" checksum="887639978D4FDE85" modified="2006-03-21" version="1">MADLASRITKPSDEPVDAVAPAPTATTGEGNGTEEPVDDGVNKGLVETTYDVEVKLSGLQADDESLLYSGVASFEELGLAKSINDGLLAMNFKKPSKIQEKALPLMLSNPPRNMIAQSQSGTGKTAAFVLTVLSRVDLTKPTQPQALLLAPSRELARQIQSVIQTIGQFCENLNVEAAIPGSISRETGVRANVVVGTPGTVMDLIRRRQFDVSQLKIMVIDEADNMLDQQGMGDQCVRVKGMLPKDIQTLLFSATFPEKVMIFARKYATNAHEIKLRHTDLTVKGISQMYMDCPDESKKYDILCKLYGLMTIGSSVIFVRTRESASEIQRRMEADGHKVSALHGAHEGQNRDALLDDFRSGRSKVLITTNVLARGIDVSSVSMVINYDIPMKGPGDKEPDMETYLHRIGRTGRFGRVGVSISFVYDRKSYDALSKIADHYGLDLVQLAPDDWDATETKVQEVIKSSRARPDYVPNAGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGV5</accession>
    <name>Q2HGV5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal RNA-processing protein 7 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_00549</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219770.1">
        <property type="nucleotide sequence ID" value="XM_001219769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGV5"/>
    <dbReference type="STRING" id="306901.Q2HGV5"/>
    <dbReference type="GeneID" id="4387902"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00549"/>
    <dbReference type="eggNOG" id="KOG4008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036234_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HGV5"/>
    <dbReference type="OrthoDB" id="5390at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12293">
        <property type="entry name" value="dRRM_Rrp7p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040447">
        <property type="entry name" value="RRM_Rrp7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040446">
        <property type="entry name" value="RRP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024326">
        <property type="entry name" value="RRP7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 7 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17799">
        <property type="entry name" value="RRM_Rrp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12923">
        <property type="entry name" value="RRP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rrp7 RRM-like N-terminal" evidence="4">
        <location>
            <begin position="10"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 7 C-terminal" evidence="3">
        <location>
            <begin position="119"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ92314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="24675" checksum="F9E3D85AA79600B9" modified="2006-03-21" version="1">MASGPATIGEFSILPVSIAPLPSFPKNVVHYLYVRRNAPKIPTVADARSLFLTNVPVDSTEAHLRALFASLVGAGRFESATFEDERKDAHSLAQSPIDAAQPAHAARLLQAHGKKRKREDEEAERAQKSRGTSAEHMDSAIAEERGGRAAPASRNEAEEAKRKMLERQDKKKEELTNFYRFQLRERKKEEQAELLKKFEDDRRKLEAMRVKRGKFVPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGY2</accession>
    <name>Q2HGY2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-lysine N-methyltransferase EFM6</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Elongation factor methyltransferase 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">EFM6</name>
        <name evidence="2" type="ORF">CHGG_00522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219743.1">
        <property type="nucleotide sequence ID" value="XM_001219742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGY2"/>
    <dbReference type="FunCoup" id="Q2HGY2">
        <property type="interactions" value="349"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HGY2"/>
    <dbReference type="GeneID" id="4387983"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00522"/>
    <dbReference type="eggNOG" id="KOG2793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055721_2_1_1"/>
    <dbReference type="InParanoid" id="Q2HGY2"/>
    <dbReference type="OMA" id="RRADMRF"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03198">
        <property type="entry name" value="Methyltr_EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033684">
        <property type="entry name" value="EFM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF152">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="87"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="236" mass="26431" checksum="19B2C53870EE9940" modified="2006-03-21" version="1">MSEQEISSSPEFSPLAFGEDLAPLPEYKEAGTTQVDFSGLLDEPLKLHEDLKSGCGGQLWPAGMVLAKHMLRYQRDKLQPARILELGAGGGVVGLTIAKGCVNLDHPLYLTDILEMEPLMQHNISLNGLDDRVKARVLKWGEPLSQEVLQFKPDIILAADCVYFEPAFPLLMQTLQDLLALTPSATVFFCFKKRRRADMQFIKAAKKAFTVTEIEDEDRPVFSRSSLFLYAFTHKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHA1</accession>
    <name>Q2HHA1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219624.1">
        <property type="nucleotide sequence ID" value="XM_001219623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHA1"/>
    <dbReference type="STRING" id="306901.Q2HHA1"/>
    <dbReference type="GeneID" id="4387320"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00403"/>
    <dbReference type="eggNOG" id="ENOG502QS7Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020266_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHA1"/>
    <dbReference type="OMA" id="LLWRHHC"/>
    <dbReference type="OrthoDB" id="28868at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.390">
        <property type="entry name" value="Hemimethylated DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011722">
        <property type="entry name" value="Hemimethylated_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036623">
        <property type="entry name" value="Hemimethylated_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032698">
        <property type="entry name" value="SirB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31350:SF27">
        <property type="entry name" value="HEMIMETHYLATED DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31350">
        <property type="entry name" value="SI:DKEY-261L7.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13369">
        <property type="entry name" value="Transglut_core2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08755">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00992">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141255">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="2"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="626" mass="72036" checksum="53ADC528D64A47E9" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHD5</accession>
    <name>Q2HHD5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Centrosomin N-terminal motif 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_00369</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219590.1">
        <property type="nucleotide sequence ID" value="XM_001219589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHD5"/>
    <dbReference type="STRING" id="306901.Q2HHD5"/>
    <dbReference type="GeneID" id="4387836"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00369"/>
    <dbReference type="eggNOG" id="ENOG502QU0H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000791_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HHD5"/>
    <dbReference type="OMA" id="GNILFWP"/>
    <dbReference type="OrthoDB" id="10255000at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024545">
        <property type="entry name" value="Mto1-like_Mto2p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47357">
        <property type="entry name" value="COP1-INTERACTIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47357:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT 110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12808">
        <property type="entry name" value="Mto2_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="5">
        <location>
            <begin position="369"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Mto1-like Mto2p-binding" evidence="6">
        <location>
            <begin position="1185"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="97"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="259"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="437"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="688"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1120"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1216"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="538"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="622"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="718"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="688"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1133"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1167"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1227"/>
            <end position="1240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ92134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1240" mass="138726" checksum="C4BD74216E346B56" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHM7</accession>
    <name>Q2HHM7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219498.1">
        <property type="nucleotide sequence ID" value="XM_001219497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHM7"/>
    <dbReference type="GeneID" id="4387335"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00277"/>
    <dbReference type="HOGENOM" id="CLU_2527246_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHM7"/>
    <dbReference type="OrthoDB" id="10435568at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209184" evidence="1">
        <location>
            <begin position="17"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="84" mass="8756" checksum="6291B1312871C38A" modified="2006-03-21" version="1">MRFFTVLAVVAGAVTALPQPVTEPETPANANLNKRYCNVMLVATVICTATAHTATPVMQATRGASAIAAMAELIQGRDKLQVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHY6</accession>
    <name>Q2HHY6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219389.1">
        <property type="nucleotide sequence ID" value="XM_001219388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHY6"/>
    <dbReference type="STRING" id="306901.Q2HHY6"/>
    <dbReference type="GeneID" id="4387857"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00168"/>
    <dbReference type="eggNOG" id="ENOG502S054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079417_0_2_1"/>
    <dbReference type="InParanoid" id="Q2HHY6"/>
    <dbReference type="OMA" id="AVMDMGR"/>
    <dbReference type="OrthoDB" id="9983919at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585:SF1">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="136" mass="15195" checksum="EBB9DFBDA8F4627C" modified="2006-03-21" version="1">MGTKGHEMAESDRKDHHRVKELLKEFQNMKPQEPDYIPKLNELWGVLSAHIEEEEHQDLPALESALTTAQAAGESERLAKKFGLTKALVPSRSHPSAGENPYFESALGMLAAPIDHIADIMRKFPEEKISPNPSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GLW7</accession>
    <name>Q2GLW7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Senescence-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_11105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408039">
        <property type="protein sequence ID" value="EAQ82869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GLW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_11105"/>
    <dbReference type="eggNOG" id="ENOG502S18N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112614_2_1_1"/>
    <dbReference type="InParanoid" id="Q2GLW7"/>
    <dbReference type="OMA" id="CTRTESQ"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ82869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="11983" checksum="8C654D4FAB0E35AC" modified="2006-03-21" version="1">MNAWPPQASYPCGNFSGTSSLKFRGTKGSIGHTFMVCIHTENQNQGDFYPFVLLEISVLHEPPLGHLRYGLTDVPPQPNSPPDNVFNPGRPAKDLKTRSWDENPAPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM00</accession>
    <name>Q2GM00_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_11056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408038">
        <property type="protein sequence ID" value="EAQ82880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230232.1">
        <property type="nucleotide sequence ID" value="XM_001230231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GM00"/>
    <dbReference type="STRING" id="306901.Q2GM00"/>
    <dbReference type="GeneID" id="4397363"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_11056"/>
    <dbReference type="eggNOG" id="ENOG502SPCK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_12_0_1"/>
    <dbReference type="InParanoid" id="Q2GM00"/>
    <dbReference type="OMA" id="IPRTIGW"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ82880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="36072" checksum="392194DC885A918F" modified="2006-03-21" version="1">METNILITGAAGYMSEEQAIALSKLEITVLQLDLTNENAVVESILRHNVGIVIHTASSLNTDIALHLVTALAKQKEVSKQETYMIHTSGESAFTTSSGWPHGETNDAGPLFETEKELADSYPLRKTDVSVIEHAKATGVTSFIVIPPMVYGKGSGQWNQLSVLLPVYVQGSISAKAVRKFANDGTVSAVHISDIAVFYEKMVEKILLKEPIPSGEKGYYFAKAHDVQWWEVFDQLAVALEARGLATNSTVETWPDDETAAKVLGVPVQFVSILWQSVSHMFAVNKQEIGWEPVWDKERLLTNIDDEIDAVLELGQAKSSLVASLFDAAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMC7</accession>
    <name>Q2GMC7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_10877</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226144.1">
        <property type="nucleotide sequence ID" value="XM_001226143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMC7"/>
    <dbReference type="FunCoup" id="Q2GMC7">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="GeneID" id="4397102"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10877"/>
    <dbReference type="eggNOG" id="ENOG502SMQG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GMC7"/>
    <dbReference type="OMA" id="HCASQNV"/>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF161">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="33"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ83059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="379" mass="41582" checksum="54521516ED813CA9" modified="2006-03-21" version="1">MFEYVEFPVLPIVKVHLIINSVLALLTVVVVGLRLASRFISGAGLWWDDYLIIFALPQGLGMLIIQGLWSPMGIGFNITETMPNLENILKMLVAYELIYATSISTIKLSILLFYLRVFVNRGLRMATVAALIFVSVWSIGNFLQVFLICRPFAKTYTPLMEGECGDQVASFIAIGSFNIITDVIILTLPLPTVWALKMSTPAKLGLTGVFLVGLVVSVIGIIRIVTLTQLDLMNLTGTMIWADFWSATEPNLAILCVSLPMMGSLWSRCVATRRGNSKLAYHSSESGTHGSAFSKLKNQSATDTQIPLEGLYAANQTVQYRSAVAATDGPRPDHDVEAGNFADKDKDSGSEVALTEQPPYRTDPQTGIRVQTKWSISHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GME5</accession>
    <name>Q2GME5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_10859</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226126.1">
        <property type="nucleotide sequence ID" value="XM_001226125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GME5"/>
    <dbReference type="STRING" id="306901.Q2GME5"/>
    <dbReference type="GeneID" id="4397147"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10859"/>
    <dbReference type="eggNOG" id="ENOG502S522">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2183653_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GME5"/>
    <dbReference type="OMA" id="HCHGITI"/>
    <dbReference type="OrthoDB" id="2117453at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ83041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="109" mass="12229" checksum="2BD6AA43E229107B" modified="2006-03-21" version="1">MVFNSVWTLLLLAYLFLTPLYYARFFHGVVALALEWITMIFWFAGSIALAAYWGSPRCDGNTYCGSTEAAIAFGFFIWALFAFLVFVDTLAFLRGRGHSTAQPKPNVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMF3</accession>
    <name>Q2GMF3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226118.1">
        <property type="nucleotide sequence ID" value="XM_001226117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMF3"/>
    <dbReference type="GeneID" id="4397244"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10851"/>
    <dbReference type="eggNOG" id="ENOG502RKH1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_537463_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GMF3"/>
    <dbReference type="OMA" id="ERISYCC"/>
    <dbReference type="OrthoDB" id="4560010at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="507" mass="56871" checksum="90712798EB57D902" modified="2006-03-21" version="1">MPPEPLPRMHVAHMHLHIRHPHAPAARPAPPRLSESGGGGVVAGGGLDAVDYGAFVVGLEGREGRAEGGGLRAGEGFDVGEGGVSVDVWLARAEEVEVGAVDEEGGGESGFVLWLWAMMTQMLEAQKNYYEKKLAEKSTKRQKTTFEKVPELKKKEDFLTWRDKLLTSLKSAGLEAHILTGVPEPADDDEKRQWRYDRIDVDNLIQSTIADINVWTLLRGQGWKVTDQDPKSTFDHLTQHFDKYTHKATYDIAREFFNIRRGDYDKFTTFQIRLNYLYQRINETDYKMQESAATLNAIQAISDAYPDLYTRSMTNLRNNKLSWADLMLEFNELASQEATQPALSNVKYGKDKTKRAEGDATSSSSNTRSTSMTNKNNERQNSWKSKNQRVDCKECDKDIYTGQEHCGGCGFHYPKASICWWCNPEQAPENWPKRDSALKAKATKTSSSTSTSLTKSSSASSSTTGPLHQQSGVANQSRPMNLLFTSNHPDMNMMNMAPHFWGGPWRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GML8</accession>
    <name>Q2GML8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ82968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226053.1">
        <property type="nucleotide sequence ID" value="XM_001226052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GML8"/>
    <dbReference type="GeneID" id="4397357"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10786"/>
    <dbReference type="eggNOG" id="ENOG502SNEG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_811327_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GML8"/>
    <dbReference type="OrthoDB" id="4589821at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ82968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="38599" checksum="B7E5F44484E96CF3" modified="2006-03-21" version="1">MPGRFDPTLTARERLHRMLQLEWLSRTTRLLRSLLDTGALPPDVLALDLSPSGEVLWTSTEDEYNGAPAAPITVVSGTRFRSCAAASSPTHPAHRLARCRGAHGAWVVGFTTPFVSARSLEKPLPGPFKLRWLRELMGLVDELNLEYGIVHQHIAPRNLFINPDTDSILLFDFSAAAQMGKTWRRSRAKWRSYTNFEERERNDITGVAYFLYMVITRDPAYRFIRFDAMADDEFDDLAKWTQHPQFTPLDHPLAIFHAELTAWIRKRRAQAAAEPEPDQPKLPNQSTPHNHNRTHSHSHNHNKTPAATITKHLLPPPNKSLSPLPPALPPTNTPSPPPSPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMY7</accession>
    <name>Q2GMY7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_10667</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228594.1">
        <property type="nucleotide sequence ID" value="XM_001228593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMY7"/>
    <dbReference type="GeneID" id="4397045"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10667"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GMY7"/>
    <dbReference type="OMA" id="WVICIGM"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF53">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="52"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ84263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="501" mass="55634" checksum="844ED27A69CBAF80" modified="2006-03-21" version="1">MDSEKEIAQQAEQVRVKSSKDGDLSDASMPDSELEWTEEEERALRRRIDWHTVPLVTVLYMLCFLDRINIGNASIQGLSKDLELGVGVRFNWALSIFYIVYLIVEVPSNIILKHVGPRYYLPFLVCGFGLVSLCTAFVHDFAGLMVVRVFLGVFEGGAFPGLAFFLSCFYKRNELLFRVGIYVSAASIAGAFGGLLATGLSKIPEWGVASMRIARWRNIFFFEGIITILVGLAAPIWMPTTPSEARFLTPRQRRIAAERLIRENKADPAARVTWADMKQAVFCIHNYTCALGFFLINITVQGLSVFMPTILTDLGWTDTKAQLYSVPPYVAACLVAIAVAYGSDKTHQRGIWLAAFSCLAVIGFAILRWVEDPNLRYMAIYFVTVGAFPGGPGFLAWSLNNAGSPTVRAVSSGYVVTLGTIGGIVATWTYTKADGPKYHTGHTINLCGQIAAVLLSIFGILYCMYENKARAAGKRDHRLEGLTEHEKDNLGRKHPNFRYWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN31</accession>
    <name>Q2GN31_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228550.1">
        <property type="nucleotide sequence ID" value="XM_001228549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN31"/>
    <dbReference type="STRING" id="306901.Q2GN31"/>
    <dbReference type="GeneID" id="4396268"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10623"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_308363_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GN31"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF79">
        <property type="entry name" value="HSP70 FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G15200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="907" mass="99016" checksum="A8F76CDC44161954" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN73</accession>
    <name>Q2GN73_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_10581</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228508.1">
        <property type="nucleotide sequence ID" value="XM_001228507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN73"/>
    <dbReference type="STRING" id="306901.Q2GN73"/>
    <dbReference type="GeneID" id="4396719"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10581"/>
    <dbReference type="eggNOG" id="KOG0513">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_125_6_1"/>
    <dbReference type="InParanoid" id="Q2GN73"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07216">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="110"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="114"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="154"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="4">
        <location>
            <begin position="297"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ84177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1079" mass="119428" checksum="2A2A15CC943DD702" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GP52</accession>
    <name>Q2GP52_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_10252</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228179.1">
        <property type="nucleotide sequence ID" value="XM_001228178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GP52"/>
    <dbReference type="FunCoup" id="Q2GP52">
        <property type="interactions" value="482"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GP52"/>
    <dbReference type="GeneID" id="4396483"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10252"/>
    <dbReference type="eggNOG" id="KOG1441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019048_3_0_1"/>
    <dbReference type="InParanoid" id="Q2GP52"/>
    <dbReference type="OMA" id="IWFRSPT"/>
    <dbReference type="OrthoDB" id="1588579at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="137"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="533"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ83848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="584" mass="63403" checksum="4B5E98AE73395F54" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPW9</accession>
    <name>Q2GPW9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Regulatory P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227912.1">
        <property type="nucleotide sequence ID" value="XM_001227911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPW9"/>
    <dbReference type="STRING" id="306901.Q2GPW9"/>
    <dbReference type="GeneID" id="4396540"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09985"/>
    <dbReference type="eggNOG" id="ENOG502QQSB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031217_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPW9"/>
    <dbReference type="OMA" id="EGNDIWG"/>
    <dbReference type="OrthoDB" id="2099887at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027589">
        <property type="entry name" value="Choice_anch_B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04312">
        <property type="entry name" value="choice_anch_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38787">
        <property type="entry name" value="REGULATORY P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38787:SF1">
        <property type="entry name" value="REGULATORY P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208475" description="Regulatory P domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="51820" checksum="957ABC41F9A9C49E" modified="2006-03-21" version="1">MKANTLLAVAAALGPLGVAAGSPVTASKMEEMMDIKTKQWDAARARGLFGGSTLYRKVTAKQRCINGVAGKGTAAYRCNNVDLHGFLSHEDLASATKAGNDVWGWTAPGGREFGIVGQTDGVGFVEITRNGNLEYLGRLDTQTTATSWRDIKVIGHHAYIGAESDNHGLQVFDLTKLLDIKPWWNPFFWQPRVFSKERDLTALFTGFGASHNIVAHEEAHMIYAVGGRSGANARNTTCAGGMFMVDVSDPANPVSPGCIAHDGYVHDAQCVVYTGPTEKYRGREICFNYNEDTLTIMDVTDKKNPEVVSRTPYEGAAYTHQGWLVDETMTFLLLDDELDEMDGTVPGEKDHTTTYIFNVTNLAEPIKTGFYQSPAKSIDHNQYVVKGLTYQANYGSGLRVVDVSGVERDPTGGNFEEVGFFDCHPEDDDVNGVVEFLGTWSVYPYFKSGYILLNSIERGIFSLKYTGRKAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQD1</accession>
    <name>Q2GQD1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">(4-O-methyl)-D-glucuronate--lignin esterase</fullName>
            <ecNumber evidence="7">3.1.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_09823</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O = 4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67452"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:171667"/>
            <dbReference type="ChEBI" id="CHEBI:171668"/>
            <dbReference type="EC" id="3.1.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:67453"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate esterase 15 (CE15) family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.117" evidence="7"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227750.1">
        <property type="nucleotide sequence ID" value="XM_001227749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQD1"/>
    <dbReference type="ESTHER" id="chagb-q2gqd1">
        <property type="family name" value="Glucuronoyl_esterase"/>
    </dbReference>
    <dbReference type="GeneID" id="4396401"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09823"/>
    <dbReference type="eggNOG" id="ENOG502QS8Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028869_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GQD1"/>
    <dbReference type="OMA" id="SHCQFPS"/>
    <dbReference type="OrthoDB" id="3781271at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054579">
        <property type="entry name" value="GCE-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22244">
        <property type="entry name" value="GCE_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208344" description="(4-O-methyl)-D-glucuronate--lignin esterase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="4-O-methyl-glucuronoyl methylesterase-like" evidence="9">
        <location>
            <begin position="99"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ83419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="396" mass="41528" checksum="A3738210DA50C1AA" modified="2006-03-21" version="1">MVHLASALLVAGAAFAVAAPASEIFERQECSVKDSYPTVNSAKLPDPFTNAAGTKITTKADFECRRAEISKIMQQYELGEYPPAPDKVEASMSGTGITVKVTVGSKSISFSASIRKPSGSGPFPAIIGIGGASIPIPSTVATITFNNDEFGAQSGSGSRGRGKFYDLFGSGHSAGSLTAWAWGVDRLIDGLEQVGASSGIDTKRLGVTGCSRNGKGAFITGAFVDRIALTIPQESGAGGAACWRISDQQKSSGANIQTAQQIVGENPWFSKNFDPYVRSVPTIPQDHHFLSAMIVPRGLIAFENNIDWLGPVSTTGCMKAGRAIYKAYGVPNNMGFSLVGGHNHCQFPSNQNAELTSYINYFLLNSGTAPGAVERSDVTADLASWAPWAASAPTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQJ5</accession>
    <name>Q2GQJ5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227686.1">
        <property type="nucleotide sequence ID" value="XM_001227685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQJ5"/>
    <dbReference type="STRING" id="306901.Q2GQJ5"/>
    <dbReference type="GeneID" id="4396330"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09759"/>
    <dbReference type="eggNOG" id="ENOG502S01H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1151680_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQJ5"/>
    <dbReference type="OrthoDB" id="5392202at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052999">
        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180">
        <property type="entry name" value="CONSERVED MITOCHONDRIAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180:SF2">
        <property type="entry name" value="PEROXISOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="241" mass="26175" checksum="9BA22408DCA2890E" modified="2006-03-21" version="1">MSAPAAKNGKRNRKAAGNEENKQLVKHTAGAVTQAQPQTMSKLSPSLKALINAPSARPGQAPAPRHIRDVYTRIAHEARERKYGDRPWVTLSAAATFTLNSPASLLALHSLLTPTLTPTLTPLTAAETAPAKFGLKCISFNGIPAHHQHAGRLPRSASPTTPGHATLRTTPTRAVTTPEGLAGVAGTRGERLWESVLYRRSRASWWRGWRTVTPTYRCIFWGVIMARCWRIRGLGGRWGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQQ6</accession>
    <name>Q2GQQ6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase II-associated protein RBA50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_09698</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RPAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227625.1">
        <property type="nucleotide sequence ID" value="XM_001227624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQQ6"/>
    <dbReference type="FunCoup" id="Q2GQQ6">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="GeneID" id="4396241"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09698"/>
    <dbReference type="eggNOG" id="KOG1894">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031074_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GQQ6"/>
    <dbReference type="OMA" id="DQESPYY"/>
    <dbReference type="OrthoDB" id="348201at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039913">
        <property type="entry name" value="RPAP1/Rba50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013929">
        <property type="entry name" value="RPAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013930">
        <property type="entry name" value="RPAP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483:SF18">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08620">
        <property type="entry name" value="RPAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08621">
        <property type="entry name" value="RPAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RPAP1 N-terminal" evidence="4">
        <location>
            <begin position="78"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1 C-terminal" evidence="3">
        <location>
            <begin position="314"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ83294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="49219" checksum="D9070608041E001D" modified="2006-03-21" version="1">MDATLGILDIDAREINDVAPPKPRAASTGFPASKKRVSAFKKQSQGNPSTASPVPTSGNSPAQTSTPRRDAKVDERRGIDEENKAVLDSMTPEEIAQAQRDLISGTNPRLLQMLLRRANLDEPTGPSPFDVAAPESLPTPNPPAPPPPSTKPRQVTIEDVPEEIHETRPKPTPVSNNNNVLKKPVVDFDEDAEPPVPPPNLFPVTSIGRLKRAAPKPAPPTPPATATAITNDTNNNPLAADIPHNTHFPPAPTVPDLDPSDPNFLENMHQKFFPTLPADPSKLAWMAPLPTPDSAADRESPYYPGQDSLPVSALRFDFRGALVPPRASRLIPVSKGLHHHGEAPEAAGYTVLELARLARSAVASQRCLAYQTLGRVLYRLGKGEWGQGVGGRGGEEDDLAFGLWRCLKEGRVLESLEEEAGLPEWKGHMSSKAYATEALWLFEKGGWKEKWRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GR58</accession>
    <name>Q2GR58_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Modin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_09546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227473.1">
        <property type="nucleotide sequence ID" value="XM_001227472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GR58"/>
    <dbReference type="STRING" id="306901.Q2GR58"/>
    <dbReference type="GeneID" id="4395188"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09546"/>
    <dbReference type="eggNOG" id="ENOG502SXX6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009106_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GR58"/>
    <dbReference type="OMA" id="EKVMGGW"/>
    <dbReference type="OrthoDB" id="5227693at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ85532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="672" mass="76455" checksum="54E6B3523B127D4D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRA4</accession>
    <name>Q2GRA4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_09500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227427.1">
        <property type="nucleotide sequence ID" value="XM_001227426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRA4"/>
    <dbReference type="GeneID" id="4395751"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09500"/>
    <dbReference type="HOGENOM" id="CLU_3207573_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRA4"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ85486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="45" mass="5106" checksum="33EB342A2D4242B3" modified="2006-03-21" version="1">MLLGWWTYSRRTPSVRASVAPLWRVKKALDGMVMSRSPVSVLSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRG8</accession>
    <name>Q2GRG8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lytic polysaccharide monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_09436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227363.1">
        <property type="nucleotide sequence ID" value="XM_001227362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRG8"/>
    <dbReference type="GeneID" id="4395065"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09436"/>
    <dbReference type="eggNOG" id="ENOG502S005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032571_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GRG8"/>
    <dbReference type="OMA" id="KWHTIYS"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF2">
        <property type="entry name" value="LYTIC POLYSACCHARIDE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208529" description="Lytic polysaccharide monooxygenase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ85422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="39503" checksum="251C707A625D2F37" modified="2006-03-21" version="1">MTIYTTSFAALALLLGTAHGHMVMTTPTPFNLHGTAKLLQVDPLGKFPFPCQGLFDTVETTSITAGNLQTVKINGGAQHGGGSCQFSLTYENPPPADKSKWKTIYTIIGGCPVSAAGNLPVTGTDADGRAQSLQCGNDSGVECIRQFDIPFPKELPNGNATFAWTWYNKIGNREVYMNCAPVSITGGADNQQFFDELPPIFLANVPGECTTGQGVFNIPNPGRFGRVLEQPLPGNEGSCPKVADVPTFEGSSGGGSGSGSGSGSGSGESSSIIASPVPSASAPPVASPPRASSGFITQTVPAGASSTSVVTPPVPSATNGGGSGSVPPGGQPCSPNGAIICFSPTSFGLCANGLAIPQQVAAGTTCNAGVISRRSAKWVPRLKRNNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRS2</accession>
    <name>Q2GRS2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chitin-binding type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_09332</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227259.1">
        <property type="nucleotide sequence ID" value="XM_001227258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRS2"/>
    <dbReference type="GeneID" id="4395527"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09332"/>
    <dbReference type="eggNOG" id="ENOG502RVPZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_612495_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRS2"/>
    <dbReference type="OMA" id="CPVTETM"/>
    <dbReference type="OrthoDB" id="4590670at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11618">
        <property type="entry name" value="ChtBD1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208543" description="Chitin-binding type-1 domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="5">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="400"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ85318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="447" mass="46242" checksum="DA24423DD3E63245" modified="2006-03-21" version="1">MRLFTSTFIAGTLLGFGLAQLEVSPDGSCGPANGYSCTGSEYGNCCSEGGECGGTDEVCGAGCQVDFGLCGRGVGGDPTDPPENEPTTTRRTELPGTTTTRRTALPTSDLPVVSTIYVTSTILTTIQTTAVQSTLITVTSTSVDRLTTTIPTTEVLTSTVVLNTTSTQFTTTTATSYSIIFATVYNTINVTSVSTEWETATTTSTQTLNTTQYFNQTLTSTFTQPITLTSYASVDVTRTINATSTKLLTQTATIPFTITSTATRTVNSTVLTTETETTEIPVTVTTIDTEFTTQTDLITATTTAITTATQNITSTAVQTQTQTQTQTITATALETATVTITETATATPTEPTTPPLTITATATITETITPTEPTTPPATITVTETATETATETATATLTQTKTQTLTPEIPPPEQTLTVGPGPDPTTGTGTGTGSSSAKVTLTVGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GT48</accession>
    <name>Q2GT48_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_08856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226783.1">
        <property type="nucleotide sequence ID" value="XM_001226782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GT48"/>
    <dbReference type="GeneID" id="4395814"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08856"/>
    <dbReference type="HOGENOM" id="CLU_3068505_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GT48"/>
    <dbReference type="OrthoDB" id="4140664at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="53" mass="5381" checksum="0E660791C18A6F10" modified="2006-03-21" version="1">MASKPSTCCGKSAECICANADVSGPCDGSCNCSGSEDGAFDPSEHETDFTTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTC4</accession>
    <name>Q2GTC4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_08780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ84766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226707.1">
        <property type="nucleotide sequence ID" value="XM_001226706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTC4"/>
    <dbReference type="STRING" id="306901.Q2GTC4"/>
    <dbReference type="GeneID" id="4395731"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08780"/>
    <dbReference type="eggNOG" id="ENOG502R4GW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024451_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTC4"/>
    <dbReference type="OMA" id="MINGMMR"/>
    <dbReference type="OrthoDB" id="2117459at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="LEC1-like"/>
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        <property type="entry name" value="LEC1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024555">
        <property type="entry name" value="PX-associated"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185:SF2">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF3818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12828">
        <property type="entry name" value="PXB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="21"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="326"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="542"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="589"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ84766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="621" mass="67704" checksum="97B45826C3997564" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTM7</accession>
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        <recommendedName>
            <fullName evidence="19">Chromatin remodelling complex ATPase chain ISW1</fullName>
        </recommendedName>
    </protein>
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        <name evidence="17" type="ORF">CHGG_08677</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
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        <property type="nucleotide sequence ID" value="XM_001226603.1"/>
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    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_0_2_1"/>
    <dbReference type="InParanoid" id="Q2GTM7"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031010">
        <property type="term" value="C:ISWI-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.30:FF:000003">
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1190">
        <property type="entry name" value="iswi atpase"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="entry name" value="ISWI, HAND domain"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Tandem AAA-ATPase domain"/>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR044754">
        <property type="entry name" value="Isw1/2_DEXHc"/>
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    </dbReference>
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        <property type="entry name" value="SANT/Myb"/>
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        <property type="entry name" value="SLIDE"/>
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    </dbReference>
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        <property type="entry name" value="SNF2_N"/>
    </dbReference>
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        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="198"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="494"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="16">
        <location>
            <begin position="861"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="129"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="819"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1066"/>
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        </location>
    </feature>
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        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="43"/>
            <end position="53"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
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        </location>
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        <location>
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            <end position="1106"/>
        </location>
    </feature>
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        <location>
            <begin position="1107"/>
            <end position="1117"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAQ84663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1125" mass="128674" checksum="3315CD42B54E07AE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTV0</accession>
    <name>Q2GTV0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_08604</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226531.1">
        <property type="nucleotide sequence ID" value="XM_001226530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTV0"/>
    <dbReference type="GeneID" id="4395806"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08604"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GTV0"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ84590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="56070" checksum="6BEA2E685CF8AD16" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUH1</accession>
    <name>Q2GUH1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Iron-sulfur cluster assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_08383</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226310.1">
        <property type="nucleotide sequence ID" value="XM_001226309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUH1"/>
    <dbReference type="STRING" id="306901.Q2GUH1"/>
    <dbReference type="GeneID" id="4394713"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08383"/>
    <dbReference type="eggNOG" id="KOG3361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_930668_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUH1"/>
    <dbReference type="OrthoDB" id="1925777at2759"/>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000005">
        <property type="entry name" value="Iron-sulfur cluster assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISCU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ84369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="299" mass="32440" checksum="D8613D0B1640C799" modified="2006-03-21" version="1">MTETDIPGVMLVADEIHHALPEHEPVFRERLSLFPNGCMVLVDGEEIGGYFVTFPVRQGKLPALNQLLGGFPQHADQYYLHDIAVLPALRGRGAAADGIGQILEVAKPYPTTCLISVYGTVSYWHRFGFVRGPVDAAMEEKLSSYGSDATYLRTEAVNVTRLYYSRPRNVGTLDKSDSSVGEGLVGAPACGDVMRLHIKVDPDTQVISDVRFKTFGCGSAIASSSYLTELVRGMTLDQAAKVKNTEIAKELCLPPVKLHCSMLAEDAIKSAINNYYKKNPDVKTTNLAGTAAKLETATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUK2</accession>
    <name>Q2GUK2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226279.1">
        <property type="nucleotide sequence ID" value="XM_001226278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUK2"/>
    <dbReference type="STRING" id="306901.Q2GUK2"/>
    <dbReference type="GeneID" id="4394817"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08352"/>
    <dbReference type="eggNOG" id="ENOG502SJ3Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035244_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUK2"/>
    <dbReference type="OMA" id="HVLGHWD"/>
    <dbReference type="OrthoDB" id="10039566at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022185">
        <property type="entry name" value="DUF3712"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046368">
        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12505">
        <property type="entry name" value="DUF3712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="448" mass="49253" checksum="C1CC44D5F111BD96" modified="2006-03-21" version="1">MATQPEDRSDISAAPRIEPPSGNTRDAASSFDDAVGDKTQLSTGSMWEKLKQHFRRRWWIYLIATVILLAILLPLLFKVIIPAIIKNIVDDQELPVKGGFLNFTEPTRLRIGLDTLLDTPLGVKIDPVPLSLLQPPVDGADDKETPFLTLQMPEQHVNHVTDVKIPSQVVDILDHTQLVAWFNEFFDKETVDLRLKADDLSAHLGALDYQVSLDKTIKVPGLNYLKGFGVLDMQFTIPPGPSGHNMKGHLNIPNAGVLTLGMGNVTFNVMAGDINLGLVHIYNLDLKPGNNTPPFEGDFYFDELVPNLAAIMETQHESLSNGMIAFNTSGNSTFHNGRRIDYVEGVLNRKHIPFTIPVTTLLLDVLSGVLAGGTDGSSGVPLLDTLGDVLGNKTLFDQMLGHFDTQSIGSSSEVTDTARLKRTAARKLGRSMQMNLFRLGLRTMRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV77</accession>
    <name>Q2GV77_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225783.1">
        <property type="nucleotide sequence ID" value="XM_001225782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV77"/>
    <dbReference type="FunCoup" id="Q2GV77">
        <property type="interactions" value="765"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GV77"/>
    <dbReference type="GeneID" id="4394488"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08127"/>
    <dbReference type="eggNOG" id="KOG2957">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051277_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GV77"/>
    <dbReference type="OMA" id="MTYGYMI"/>
    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="347" mass="38584" checksum="BFBD9C54ED661A19" modified="2006-03-21" version="1">MEGLLFNVNNGYIEGIVRGYRNGLLTGTNYTNMTQCETIDDLKLQLGPAYGDFLATLPPNPSTSSLATKTTEKLVSEFRYVRANAVGSLAKFMDYVTYGYMIDNVALLITGTLHERDTRELLDRCHPLGWFETMPVLCVATNIEELYNSVLIETPLAPYFKGSLSHQDLDELNIEIVRNTLYKNYLEDFYEFVNSHPDMAGTPTAEVMSEMLEFEADRRAINITLNSFGTELSKADRKKLYPSFGNLYPEGTLMLSRADDFEGVRLAVEGVSDYKAFFEAAGLGGGPGGPGNMAGGSGSDGRSLEDMFYQKEMEIAKGAFTRQFTFAIVYAWVKLREQVSTPSSRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVH1</accession>
    <name>Q2GVH1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225689.1">
        <property type="nucleotide sequence ID" value="XM_001225688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVH1"/>
    <dbReference type="GeneID" id="4393485"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08033"/>
    <dbReference type="eggNOG" id="ENOG502QV1E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030124_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GVH1"/>
    <dbReference type="OMA" id="THASWEK"/>
    <dbReference type="OrthoDB" id="2831558at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF13">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="73"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="494" mass="56868" checksum="3FB84631AE6708C2" modified="2006-03-21" version="1">MGLASIDLDFPIRVSQTHESYPPADDLHRYWRSHEDEGYLERYWPDDHDHDVWVSNIRQVLTHQFPEFANAEIQYFAKGTFNRLYSLTHASWEKSYIFRVSIPVEPFFKTESEIATMEYVRQHTTMPIPRVIAFSSSDANELGYEWVLMEMMPGEPLRTLWGAMPDAARVKVFAELAVHVKQLVALRFSKFGSLYFADVSDQVLPRNVSSPVKEGNDDEVVDKDIGPGGRFVLGRIVAQDFFFDKRVYYPGSRGPFETTRELVDMRLELLERRLRELSPVEGAAWYCENDRELDKNKDRVYELFEQLKALVPRLVPHDNGPEDVGILWHDDLSEHNLLLDPVTFKLTAVVDWESVSVIPAYETYDARPAWLSDRDWRPTPLVQLARGIPPNDEFITADKLRRVGEMGPAREAYHRIVGSLYATTSPETQQRVKNKQGIAKQLEIATFQHRPWWTATWMAENGFFCNGQAVDTADTVDKPADPVLQNDVISDVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVX0</accession>
    <name>Q2GVX0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_07884</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225540.1">
        <property type="nucleotide sequence ID" value="XM_001225539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVX0"/>
    <dbReference type="FunCoup" id="Q2GVX0">
        <property type="interactions" value="163"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GVX0"/>
    <dbReference type="GeneID" id="4393457"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07884"/>
    <dbReference type="eggNOG" id="KOG0610">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_84_4_1"/>
    <dbReference type="InParanoid" id="Q2GVX0"/>
    <dbReference type="OMA" id="HTGAPQI"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05574">
        <property type="entry name" value="STKc_phototropin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000121">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45637">
        <property type="entry name" value="FLIPPASE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="265"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="100"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="576"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ86631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="627" mass="68634" checksum="14F1290ACE20531C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWG8</accession>
    <name>Q2GWG8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_07686</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225342.1">
        <property type="nucleotide sequence ID" value="XM_001225341.1"/>
    </dbReference>
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    <dbReference type="STRING" id="306901.Q2GWG8"/>
    <dbReference type="GeneID" id="4393611"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07686"/>
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    <dbReference type="InParanoid" id="Q2GWG8"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DHP_3-monooxygenase"/>
    </dbReference>
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        <property type="entry name" value="DhpH_subs-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47469">
        <property type="entry name" value="MONOOXYGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47469:SF2">
        <property type="entry name" value="OS06G0597600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22607">
        <property type="entry name" value="FAD_binding-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="160"/>
        </location>
    </feature>
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        <location>
            <begin position="273"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
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        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ86433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="59555" checksum="04959F91C45F3D44" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWI4</accession>
    <name>Q2GWI4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_07670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225326.1">
        <property type="nucleotide sequence ID" value="XM_001225325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWI4"/>
    <dbReference type="GeneID" id="4393906"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07670"/>
    <dbReference type="HOGENOM" id="CLU_2654277_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWI4"/>
    <dbReference type="OrthoDB" id="4842715at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ86417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="76" mass="8675" checksum="1F78C941CD1B0FBF" modified="2006-03-21" version="1">MTPLSELSMNRGEHWTSPNSQHLYLNKRLADFENRLQRPDLDDGRGGKKTAASVVLTACRKIQQRLSSRRGNRGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX67</accession>
    <name>Q2GX67_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_07437</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225093.1">
        <property type="nucleotide sequence ID" value="XM_001225092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX67"/>
    <dbReference type="STRING" id="306901.Q2GX67"/>
    <dbReference type="GeneID" id="4393846"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07437"/>
    <dbReference type="eggNOG" id="KOG1947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010840_3_1_1"/>
    <dbReference type="InParanoid" id="Q2GX67"/>
    <dbReference type="OMA" id="LCNRIRY"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050648">
        <property type="entry name" value="F-box_LRR-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382:SF67">
        <property type="entry name" value="SCF E3 UBIQUITIN LIGASE COMPLEX F-BOX PROTEIN POF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="87"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="4">
        <location>
            <begin position="236"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="607"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="671"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="636"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="679"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="725"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ86184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="772" mass="85017" checksum="A50FC708B6AE7031" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZE0</accession>
    <name>Q2GZE0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_05106</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224320.1">
        <property type="nucleotide sequence ID" value="XM_001224319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZE0"/>
    <dbReference type="STRING" id="306901.Q2GZE0"/>
    <dbReference type="GeneID" id="4391575"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05106"/>
    <dbReference type="eggNOG" id="KOG1065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005043_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GZE0"/>
    <dbReference type="OMA" id="FNTWHYG"/>
    <dbReference type="OrthoDB" id="1334205at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06595">
        <property type="entry name" value="GH31_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF89">
        <property type="entry name" value="ALPHA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="6">
        <location>
            <begin position="194"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="7">
        <location>
            <begin position="509"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="635"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="648"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ88487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="872" mass="99268" checksum="65740C4A0108F5D7" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZJ2</accession>
    <name>Q2GZJ2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_05054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224268.1">
        <property type="nucleotide sequence ID" value="XM_001224267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZJ2"/>
    <dbReference type="GeneID" id="4392905"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05054"/>
    <dbReference type="eggNOG" id="KOG1121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133923_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZJ2"/>
    <dbReference type="OMA" id="HGWFLVE"/>
    <dbReference type="OrthoDB" id="5062167at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ88435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="140" mass="15855" checksum="B8C41662A40F3CB3" modified="2006-03-21" version="1">MSSTPSLPTTPGPSAFTLMTGQAKSIATQVNEALAEASPNDETVSDLYKIVWKDRRFVLESLLYRKTSRGRRSWIKDHGWFLVELGPQDVIRGAVWACSRCDASRKPQFFAVRSTTSSTTSQRFIILSRARRIRKNLRMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZJ4</accession>
    <name>Q2GZJ4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_05052</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224266.1">
        <property type="nucleotide sequence ID" value="XM_001224265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZJ4"/>
    <dbReference type="GeneID" id="4392903"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05052"/>
    <dbReference type="eggNOG" id="ENOG502RM4B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035914_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GZJ4"/>
    <dbReference type="OMA" id="LKSKCQY"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF125">
        <property type="entry name" value="N-ACETYL-6-HYDROXYTRYPTOPHAN OXIDASE IVOB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209146" description="Tyrosinase copper-binding domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="105"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ88433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="386" mass="42682" checksum="05119BBF27B14CA2" modified="2006-03-21" version="1">MMKSIVLLASALLAGSAVSAPTAEIPSFTQAEMDSGKAIRELGRIAYENAMARAAKATTGCTKENVRIRKEWRNMTLDDRQGYQQAVQCLMEKPARHKGLDGVRTAWDDYGALHYYQTPYVHNSATFLLWHRHYNWVLEQDLRDLCGYNGVFPYWEWGLDCGSVGSMDKSPVFDGSEYSLGGNGEFIEGHRAAIGGAKPGSGGGCLTSGPFSNYTVNLGPVGSRNPLAYNPRCFKRDLNTDICNRWATLRNTTEPILNGKDIAVFQALVQGDGRWPEAARLGIAVHGGGHYAISGDPGSDFYFSSLEPGFYLHHGNIDRMHFIWQNLDWENRQTISGTNTMFNRPATPEAVLGDNMGFEPINRNVTIGQTMDTVGGTPLCYVYEPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZN7</accession>
    <name>Q2GZN7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GTP-binding protein rho2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_05009</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224223.1">
        <property type="nucleotide sequence ID" value="XM_001224222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZN7"/>
    <dbReference type="FunCoup" id="Q2GZN7">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GZN7"/>
    <dbReference type="GeneID" id="4391583"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05009"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_2_1"/>
    <dbReference type="InParanoid" id="Q2GZN7"/>
    <dbReference type="OMA" id="NDNVMRR"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035841">
        <property type="term" value="C:new growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035840">
        <property type="term" value="C:old growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903139">
        <property type="term" value="P:positive regulation of cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070610">
        <property type="term" value="P:regulation of fungal-type cell wall (1-&gt;3)-alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000573">
        <property type="entry name" value="RHO family GTPase Rho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ88390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="21995" checksum="91ED8D7E7884377A" modified="2006-03-21" version="1">MASDRNAQNVIRRKLVIIGDGACGKTSLLSVFTLGFFPTIPTVFENYVTDCRVDGKSVQLALWDTAGQEDYERLRPLAYSKAHVILIGFSVDTPDSLDNVKHKWVVEAQERCPDVPIILVGLKKDLRDDPVAIEEMRKRSQRFVSPTDGEHAAKDIGARKYLECSSLSGEGVDDVFEAATRASLLMFEKSEGNGCCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZX5</accession>
    <name>Q2GZX5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CHGG_04921</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224135.1">
        <property type="nucleotide sequence ID" value="XM_001224134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZX5"/>
    <dbReference type="STRING" id="306901.Q2GZX5"/>
    <dbReference type="GeneID" id="4393085"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04921"/>
    <dbReference type="eggNOG" id="ENOG502SD7M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063084_1_3_1"/>
    <dbReference type="InParanoid" id="Q2GZX5"/>
    <dbReference type="OMA" id="DVACCIA"/>
    <dbReference type="OrthoDB" id="3065412at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208357" description="CFEM domain-containing protein" evidence="17">
        <location>
            <begin position="19"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="107"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAQ88302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="172" mass="16114" checksum="F97324AD00F3FCD9" modified="2006-03-21" version="1">MKVPAALLTLALAGAAAAQDAGAFGLPECAASCATKFLQGGIGNCGKDIECICRNDTFLGEIACCLADVCSEADQKAAVVAAAGICDAVGVSDLPTEVACATAASSTGPAASTTASGAGSNTSPAPTGGAAGATQNPDAQSTSSESSNLGPRPTAAAGLGAIGGIIAAVALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H053</accession>
    <name>Q2H053_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224057.1">
        <property type="nucleotide sequence ID" value="XM_001224056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H053"/>
    <dbReference type="STRING" id="306901.Q2H053"/>
    <dbReference type="GeneID" id="4391874"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04843"/>
    <dbReference type="eggNOG" id="KOG2946">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059592_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H053"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="186" mass="19688" checksum="E8503E1A47F7101F" modified="2006-03-21" version="1">MAAPKRRDYQNVPAVDIDDDDDLIDPDDADLNTFDDPLSQPTTSRTTTTTTTNTTTPGLTGSIGSRSSGHASSWTSRIPGEDRTTASAASPSTIDESVWATLRRDLLAVWRKLLEVLYPRHLFAAWGGPDSLRGAYASLRSGGFAGAREELAGLAGRVLDAESLLGGGGKCRWEWCGRGVCCGAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0L7</accession>
    <name>Q2H0L7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223893.1">
        <property type="nucleotide sequence ID" value="XM_001223892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0L7"/>
    <dbReference type="GeneID" id="4392892"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04679"/>
    <dbReference type="HOGENOM" id="CLU_1133465_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H0L7"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="245" mass="27245" checksum="B943757876A7D6E0" modified="2006-03-21" version="1">MPASLDSADPSHGYGHHHRRPNPAPRSPGTPRGEGMVPRDSRDRNRDRDRNQDRDRDRDRDRQHHRPRPRPRPRSPSPAASTSATSACSCSTTTTTTASGPTATNTHSRTAHGSSNSTTTTNNRKALIPYPHQPQQQRRRRRRHGSSFSASDSDSESDDGAPEEYTVYPDGRIHEHRRRKGVGQGKEKGYRRGDGGGGYDDEEGYDEYGGGRRRLRRSRSRSREEAKGFLIAAVVLVAGIVLCCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H117</accession>
    <name>Q2H117_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_04529</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Its motor activity is directed toward the microtubule's plus end.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223743.1">
        <property type="nucleotide sequence ID" value="XM_001223742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H117"/>
    <dbReference type="FunCoup" id="Q2H117">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H117"/>
    <dbReference type="GeneID" id="4392623"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04529"/>
    <dbReference type="eggNOG" id="KOG0240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_3_1_1"/>
    <dbReference type="InParanoid" id="Q2H117"/>
    <dbReference type="OMA" id="FPMGTKQ"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23649">
        <property type="entry name" value="Khc_CBD_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000031">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059182">
        <property type="entry name" value="Khc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="6"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="790"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="402"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="535"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="658"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="798"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="87"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ87910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="825" mass="91684" checksum="7AC86B63E87A13E7" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1K0</accession>
    <name>Q2H1K0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223560.1">
        <property type="nucleotide sequence ID" value="XM_001223559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1K0"/>
    <dbReference type="GeneID" id="4392127"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04346"/>
    <dbReference type="eggNOG" id="KOG4157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077470_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H1K0"/>
    <dbReference type="OMA" id="NQCWCGT"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF3">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209194" description="WSC domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="122"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="258" mass="28069" checksum="CB22B795DDC95390" modified="2006-03-21" version="1">MRTSISFAIVSLAARHVAADEHPRLQWDPATAKDCVDWYDNTDSSRSCKEVRDLFSITPEQFHEWNPSVGLDCTPWHDWQSYCIVTLHRLETDPPPLPTTSTAKVAIIPTTTTSTLGPSPTAWEDRGCYVEDPTLPLLDQNMSGTDGDVSLTIGQCKDSCYLAAYFFAGVQEGNQCWCGTYVGSEWARNQSDCNIPCTGDKTTFCGGKGVLNIFEALENQGVSSMSITRSSAPTVAGTGIATSSTASSGARRNIAMFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H290</accession>
    <name>Q2H290_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223320.1">
        <property type="nucleotide sequence ID" value="XM_001223319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H290"/>
    <dbReference type="FunCoup" id="Q2H290">
        <property type="interactions" value="327"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H290"/>
    <dbReference type="GeneID" id="4391862"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04106"/>
    <dbReference type="eggNOG" id="ENOG502RZJP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027207_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H290"/>
    <dbReference type="OMA" id="RDRVEIM"/>
    <dbReference type="OrthoDB" id="5348546at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="111"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="521" mass="56355" checksum="D01A2E8DC3865068" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-05" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2D7</accession>
    <name>MTLD_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Mannitol-1-phosphate 5-dehydrogenase</fullName>
            <shortName>M1PDH</shortName>
            <shortName>MPD</shortName>
            <shortName>MPDH</shortName>
            <ecNumber>1.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">CHGG_04059</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NAD(H)-dependent interconversion of D-fructose 6-phosphate and D-mannitol 1-phosphate in the mannitol metabolic pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>D-mannitol 1-phosphate + NAD(+) = beta-D-fructose 6-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19661"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:61381"/>
            <dbReference type="EC" id="1.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mannitol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.17"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223273.1">
        <property type="nucleotide sequence ID" value="XM_001223272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2D7"/>
    <dbReference type="SMR" id="Q2H2D7"/>
    <dbReference type="STRING" id="306901.Q2H2D7"/>
    <dbReference type="GeneID" id="4392871"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04059"/>
    <dbReference type="eggNOG" id="ENOG502QVPN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036089_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H2D7"/>
    <dbReference type="OMA" id="APFIERK"/>
    <dbReference type="OrthoDB" id="418169at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008926">
        <property type="term" value="F:mannitol-1-phosphate 5-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019592">
        <property type="term" value="P:mannitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00196">
        <property type="entry name" value="Mannitol_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023028">
        <property type="entry name" value="Mannitol_1_phos_5_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000669">
        <property type="entry name" value="Mannitol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013118">
        <property type="entry name" value="Mannitol_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002652">
        <property type="entry name" value="PRK02318.2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30524:SF0">
        <property type="entry name" value="ALTRONATE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30524">
        <property type="entry name" value="MANNITOL-1-PHOSPHATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01232">
        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08125">
        <property type="entry name" value="Mannitol_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00084">
        <property type="entry name" value="MTLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000371525" description="Mannitol-1-phosphate 5-dehydrogenase">
        <location>
            <begin position="1"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="398" mass="44047" checksum="6C1802D7C566865A" modified="2006-03-21" version="1">MVQRNAPKKAVHFGAGNIGRGFVACFLHNSGYEVIFAEVNDTTVQKLNSQKSYKVIEVGADGTSESTITNYRAINSRLNEAELVQEIATADLVTCSVGPHILKFLAPVIAKGIDARSTDLTPVAVIACENAIGATDTLAEFIKAPENTNPDRLADYDKRARFANSAIDRIVPAQDPDAGLDVRLEKFYEWVVERTPFADHEPPAVEGIHWVDNLQPFIERKLYTVNTGHATAAYHGYIRRKSTVYDALQDREIQEEVKKALANTASLITQKHGIPQDEQQAYVDKIVRRISNPHLEDAVERVGRAPLRKLSRKERFIGPAAELAEHGKDCGALLDAAEMAFRFQNVEGDDESFKLAEIMEQNGPEDVVKQVCGLEPKEKLFPAVVDVVKRVQADTQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2I2</accession>
    <name>Q2H2I2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_04014</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223228.1">
        <property type="nucleotide sequence ID" value="XM_001223227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2I2"/>
    <dbReference type="FunCoup" id="Q2H2I2">
        <property type="interactions" value="863"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H2I2"/>
    <dbReference type="GeneID" id="4391555"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04014"/>
    <dbReference type="eggNOG" id="KOG1278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010714_4_1_1"/>
    <dbReference type="InParanoid" id="Q2H2I2"/>
    <dbReference type="OMA" id="KVYYMFG"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF111">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        <location>
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            <end position="595"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="636"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ87395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="646" mass="71464" checksum="64F1C2B9DFE9A99B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2T9</accession>
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        <recommendedName>
            <fullName evidence="13">Carbon catabolite repressor</fullName>
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        <name evidence="17" type="ORF">CHGG_03907</name>
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        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in carbon catabolite repression. Represses the transcription of a number of genes by binding to a GC-rich region in their promoter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the creA/MIG C2H2-type zinc-finger protein family.</text>
    </comment>
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        <property type="protein sequence ID" value="EAQ87288.1"/>
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    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03907"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036230_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        </location>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ87288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="425" mass="46805" checksum="E537AED5EF09C557" modified="2006-03-21" version="1">MQRAKSAVDFSSLLNPEVSAERDQILQQQQQQQQQQQQQQVQIQQQTEAEMAAVGLIRPNGPLPVGAAPAEQTTELPRPYKCTMCDKAFHRLEHQTRHIRTHTGEKPHACHFPGCSKRFSRSDELTRHSRIHNNLNSRRGNKSGHHQHASMIHRMQPDMMAPPPGPKMIRSAPPTALSSPNVSPPHYSSYSMNLPTPPTLSPYSRGVLSSQSGPDMAMLARAAGQLERDNAPGQHHYPPSRQHPYYGGVLHSARNPLPGLGAYHMSRPHSHDEHDDHYAHAYRQSKRSRPNSPNSTAPSSPTFSHNSLSPTPDHTPLATPAHSPRLRPYSGVELPPFRNLSLHHTPALAPLEPAPEGLTPPLLPTPRSNGMSLTDIMSRPDGAQRKLPVPKVAVHDLLSPADGFSTSGRSSSSNSISGVELYERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2X7</accession>
    <name>Q2H2X7_CHAGB</name>
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        <recommendedName>
            <fullName evidence="4">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
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    </dbReference>
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    <dbReference type="STRING" id="306901.Q2H2X7"/>
    <dbReference type="GeneID" id="4392008"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03869"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083369_3_0_1"/>
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    <dbReference type="OrthoDB" id="152248at2759"/>
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    </dbReference>
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        <property type="entry name" value="DUF4360"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PSEUDOURIDINE SYNTHASE RSUA_RLUA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012994612" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="19104" checksum="446C3BFFA024BFE8" modified="2006-03-21" version="1">MKFLSLLSLLPLAAAAPGLTVPNENVLNKVRVVGVSLLGSGCPAGTADVQIDASKTLLEVTFSEYIIQTGPGTKAADWRKNCKLTLNLEFDEGFSFSTLATDMSGFAQIPKGSRGLCTNTFDFTGIQGQSYYSVALAGEREGPFTLSADPDVFLRFAPDLVSKTVADDGGVWRLSDLGGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H328</accession>
    <name>Q2H328_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Regulator of phospholipase D SRF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87199.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001223031.1"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502QPXG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027163_2_0_1"/>
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    <dbReference type="OMA" id="MPIADHQ"/>
    <dbReference type="OrthoDB" id="2589563at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037737">
        <property type="entry name" value="Srf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819:SF1">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="41507" checksum="256C11A431101B2D" modified="2006-03-21" version="1">MATPGQPPSSSHHSEPRPSTRSQSTAGQSTPAQRRLTRTLPAWIDSYETRYGTPTENQIHALTSPPPRALPAHHNHSPSHAQRRVSKDGFVYENPAVLGLEGARTSRARLRKLLKRGDGSERGRKWDHLRTAEPVIVPRFSRATPDSPWHSYVLSSRYGRLPNEEAEIVDPEALDKMQPDFNSPVEIRDANGTTGRRQTRRKVLYKRLWQIILRHPLVPLAFRLTVLLTSIVALAISARIFEIEHQEEESDRSSELTQAIVAIVVDSVAIPYIGYMTWDEYTGKPLGLRAANQKIALVLMDLFFIIFKSASTALAFEALVYHNSGDRQTRQYSQALAAFQMIGLIAWSFTLAVSVFRLVQKLGGGDDDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H394</accession>
    <name>Q2H394_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_03752</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222966.1">
        <property type="nucleotide sequence ID" value="XM_001222965.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4392940"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03752"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_2_1"/>
    <dbReference type="InParanoid" id="Q2H394"/>
    <dbReference type="OMA" id="HRSHATI"/>
    <dbReference type="OrthoDB" id="5233699at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="482"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="4">
        <location>
            <begin position="773"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1037"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1185"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1255"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1323"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="16"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="966"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="966"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="981"/>
            <end position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ87133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1456" mass="160032" checksum="93E2091535B457B1" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3J9</accession>
    <name>Q2H3J9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222861.1">
        <property type="nucleotide sequence ID" value="XM_001222860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3J9"/>
    <dbReference type="GeneID" id="4390048"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06766"/>
    <dbReference type="eggNOG" id="ENOG502RR6I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_556669_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3J9"/>
    <dbReference type="OMA" id="IARCEIP"/>
    <dbReference type="OrthoDB" id="5410795at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="490" mass="54980" checksum="C566A7454881DE26" modified="2006-03-21" version="1">MSRVLGGGRLCQIMGHRRPCRIMPLTVSTMPSPSKASRPGCRGHISLAVLRTRTALLASPPFGRWNHDYMAMRHHMQPNSITIHVRTCHTAGRPRNEDDLLAPAAKQKVAKLLRQGYRGSEIYNLADIARCEIPQWVFLAMLKEDKELASLMRERKRGKWSDEEKEHLIKLTHNRRRINIESIARQIGREPDSVRSRLRLMAKKMSVELGNEAVSFSVESLDGDLGNEEQSILEARMCHVIDGMLKKRDLVTTQWKAILSAKSTEAWVATILPLIPTRVKHILAAPSPPTAADWRNLTWQDTSRFGVYAWLLKRGGSGSLNPLRVEKYLYIGSATKYGHGLFGRALQHRERHGRNSGSSLDNRIKQRGLSRATGYFATLLVTEAASLEIGDITKARELVVFAEAILTVWLEALTETESAGAPSRAEEHRRLHSLSPWNHPQQFSYKGLCSHSPLALDLESRQESAHLPEVADPGQSEDSGTMVDNRATEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3S9</accession>
    <name>Q2H3S9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodopsin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_06686</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Rhabdomere membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222781.1">
        <property type="nucleotide sequence ID" value="XM_001222780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3S9"/>
    <dbReference type="STRING" id="306901.Q2H3S9"/>
    <dbReference type="GeneID" id="4390876"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06686"/>
    <dbReference type="eggNOG" id="ENOG502RUYQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2483157_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3S9"/>
    <dbReference type="OMA" id="TTHESCF"/>
    <dbReference type="OrthoDB" id="10605375at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006031">
        <property type="entry name" value="XYPPX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02162">
        <property type="entry name" value="XYPPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ90067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="87" mass="9603" checksum="09882CCA45C0D5EF" modified="2006-03-21" version="1">MSQYPPQGGYPPQGYPPPQGYAPQPYPPQGYPPQGYPPPQPMQYHEAPPAKEEKSHGCLYTCLTTHESCFNAPVRADKPTMVCEQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4R5</accession>
    <name>Q2H4R5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_06350</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222445.1">
        <property type="nucleotide sequence ID" value="XM_001222444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4R5"/>
    <dbReference type="STRING" id="306901.Q2H4R5"/>
    <dbReference type="GeneID" id="4391221"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06350"/>
    <dbReference type="eggNOG" id="KOG0616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_5_1"/>
    <dbReference type="InParanoid" id="Q2H4R5"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000551">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="62"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="249"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ89731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="391" mass="44127" checksum="4B448A20E33FA72D" modified="2006-03-21" version="1">MAATVAHSQALPPGLHPLQVAAMRAAANGQQQQQQQSQQSQQRDFNDEPFDVTSRKLTVSDLVRVRTLGTGTFARVCLVRPSHGTEADRSKVYALKILRKTEVIKLKQIDHVRHERQILADVRGHPFITNYVASFSDHEFLYILLDYVPGGELFTYLRKFRRFDEDMARFYAAEIVLILEHLHEHQGGIAYRDMKPENLLLDGEGHIKLVDFGFAKRLGNNESGHPVETYTLCGTPEYLAPEVIHNKGHTTAVDCPPHPPKPRPFPPSPSHPNHPTPRAESSKRPIVFPQEPVISDAAKDIHPASFATFDRFRRPRLNFGGAPPEFKAHPFFAGVRLGTPSTRSATEAPSSPRVRYPGDAQCFDIYPEEDAHKDEYTDEMVGKYDAYFKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4Z0</accession>
    <name>Q2H4Z0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222370.1">
        <property type="nucleotide sequence ID" value="XM_001222369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4Z0"/>
    <dbReference type="GeneID" id="4391063"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06275"/>
    <dbReference type="eggNOG" id="ENOG502SYM4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021744_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4Z0"/>
    <dbReference type="OrthoDB" id="2099276at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF6">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="615" mass="69461" checksum="3A145607DD7E8E00" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H502</accession>
    <name>Q2H502_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal recognition particle receptor subunit alpha homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Docking protein alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_06263</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222358.1">
        <property type="nucleotide sequence ID" value="XM_001222357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H502"/>
    <dbReference type="FunCoup" id="Q2H502">
        <property type="interactions" value="713"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H502"/>
    <dbReference type="GeneID" id="4391216"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06263"/>
    <dbReference type="eggNOG" id="KOG0781">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_8_1_1"/>
    <dbReference type="InParanoid" id="Q2H502"/>
    <dbReference type="OMA" id="HLGWIDK"/>
    <dbReference type="OrthoDB" id="1727884at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005785">
        <property type="term" value="C:signal recognition particle receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
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        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="612"/>
            <end position="623"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="676" mass="73980" checksum="A77C1B845A67DB33" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5L1</accession>
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        <recommendedName>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
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        <property type="entry name" value="F-BOX DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00200)"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR42057:SF2">
        <property type="entry name" value="F-BOX DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00200)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F-box-like"/>
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    </dbReference>
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        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ89435.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="490" mass="56632" checksum="7C9FE6F8968CD4B1" modified="2006-03-21" version="1">MSIRDIPPEILNLVLGQLFEYEHDDDPESPINHGHLRNARLVCRQWHEFATRHLFRTLVLDYAPNEEVRSRQDIPWTHAVNSETIQPLVQDVVIQSHPDALDMDEDPVSDAEDWVTEDNEEDSPFDVAVASIAQLPNLKSVQIWFSEKCLGPREVGWWGDDEGVESISHRLQTLKTVFGAIQKRRANASRTSTIRSLTLKNLQNVAISDFASSDLYKDVIKDLNELHLFITHEYNEHGPDYDLDRIERQTFEPYLQNELLPPLAHQLTSLTLTFRECWGVIPAYFDGKGLVFPNLRTLTLGEFVIGHHDQFDWVLAQKSLQTLRLDRCFVVSYLRVLDSQFNEWRVPTHDWHEYPEGSFGFYGSKIFAFSGTWETVYDGIREGLPNLREFGCVHHHWHNTFDRREEMGANMSASRYIVFDAGLCPSPWISTGEYTGDMNFGNNDPAVCPMEEVAQRGRYSLQNPLNRAKETERGDTRAFEDLLQAVRERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5U5</accession>
    <name>Q2H5U5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222065.1">
        <property type="nucleotide sequence ID" value="XM_001222064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5U5"/>
    <dbReference type="STRING" id="306901.Q2H5U5"/>
    <dbReference type="GeneID" id="4390275"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05970"/>
    <dbReference type="eggNOG" id="KOG4109">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1704009_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5U5"/>
    <dbReference type="OMA" id="GCDENNA"/>
    <dbReference type="OrthoDB" id="417678at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007858">
        <property type="entry name" value="Dpy-30_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05186">
        <property type="entry name" value="Dpy-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="154" mass="16090" checksum="5F7DB71D3BCE3295" modified="2006-03-21" version="1">MSEQTAPQQIEGTEIPNPHPETVNGISAPDATDISMTDAPSPAVPQPHQHDTPTTTPAPASATARIPTPIPTPNQPPQQQQHQNQNQNQPTSRAASQHPADTTTPAGTTTTTATATGFAMPTEAAAHGAPVRQYLNSKVTGVLLEGMKIVAREQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-20" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6C5</accession>
    <name>KU80_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent DNA helicase II subunit 2</fullName>
            <ecNumber>3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>ATP-dependent DNA helicase II subunit Ku80</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">KU80</name>
        <name type="ORF">CHGG_05790</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of Ku70 and Ku80.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku80 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221885.1">
        <property type="nucleotide sequence ID" value="XM_001221884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6C5"/>
    <dbReference type="SMR" id="Q2H6C5"/>
    <dbReference type="FunCoup" id="Q2H6C5">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H6C5"/>
    <dbReference type="GeneID" id="4390172"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05790"/>
    <dbReference type="eggNOG" id="KOG2326">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010975_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H6C5"/>
    <dbReference type="OMA" id="WAMQYVW"/>
    <dbReference type="OrthoDB" id="30826at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00873">
        <property type="entry name" value="KU80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.290.10:FF:000008">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000073">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1600.10:FF:000002">
        <property type="entry name" value="X-ray repair cross-complementing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.240">
        <property type="entry name" value="Ku, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024193">
        <property type="entry name" value="Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036494">
        <property type="entry name" value="Ku_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014893">
        <property type="entry name" value="Ku_PK_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08785">
        <property type="entry name" value="Ku_PK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016570">
        <property type="entry name" value="Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101420">
        <property type="entry name" value="C-terminal domain of Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0779">Telomere</keyword>
    <feature type="chain" id="PRO_0000278351" description="ATP-dependent DNA helicase II subunit 2">
        <location>
            <begin position="1"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="Ku">
        <location>
            <begin position="232"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="736" mass="81825" checksum="95686D901D696725" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6V5</accession>
    <name>Q2H6V5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_05610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the KTI12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221705.1">
        <property type="nucleotide sequence ID" value="XM_001221704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6V5"/>
    <dbReference type="STRING" id="306901.Q2H6V5"/>
    <dbReference type="GeneID" id="4390512"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05610"/>
    <dbReference type="eggNOG" id="KOG3062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027147_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H6V5"/>
    <dbReference type="OrthoDB" id="9972657at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12435">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ88991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="335" mass="37833" checksum="89C5D6A0AFEB562E" modified="2006-03-21" version="1">MSSNFGSITKNLAATFYSLTREEFPTSYAKAPAPANYTPTSRHASPPSHPPTKPKPKPKPRPKPNQNPNPPTTCTSSRTTPSPSRAPSTTSRPRNYRRTYGRPNASEKDARAAAFGAVKRVLSPRDIVVLDGLNYIKGWRYQLYCEAKNSEHFQLCAAGGKEVEESGGKKAEGENDDDNDADDTERYKPASWENLVFRYEEPNPMARWDSPLFTLVWEDDEAQTKEVFDKIWDTIAGEGRKLVRPNQSTVQRDKDPGGDYLYILERETQASEGRRFWRGKRMRARWVRPCAKGFRRAFVALNRGGIGLEAVGTLAAERLRESFVGYLNDAFEKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H750</accession>
    <name>Q2H750_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Magnesium and cobalt transporter CorA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_05515</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221610.1">
        <property type="nucleotide sequence ID" value="XM_001221609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H750"/>
    <dbReference type="STRING" id="306901.Q2H750"/>
    <dbReference type="GeneID" id="4390227"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05515"/>
    <dbReference type="eggNOG" id="ENOG502QVFZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015119_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H750"/>
    <dbReference type="OMA" id="HCIIITE"/>
    <dbReference type="OrthoDB" id="165352at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ88896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="50656" checksum="5C8648DD3021643C" modified="2006-03-21" version="1">MATLSAPCEITVVDFSKDRLTLQRLDNKTLTGFLNLPQPEWASCRWINVNGLSWDVIQALGRHKNLHRLAIEDMMNTKNRTKAEWFPTHAFIVLTLQKLVHLYESESEDSDSESEDDTTKSVRSKRSTKSPKRLLRRLKRAFRRKPDNLGEKSLGTGRSSIPRNAGVYLRSQPTGFSEVLDISQLRTLQRYHASPNDPRTKYMEKHSALSPRNLAVACEQVSMFLTNDNCILSFFEQSAHDIETPIIRRLQTDDTIIRQSCDASLVGQAIMDAIIDLAIPVTACYDDVIGDLELDVLNRPNIGHTKSLYILISEINKVLSFISPITTLINTLRDHEAKVSPDVVMTHLLDPNHGVIITPMTYIYLGDVLDHCVLITETLNQLKGSADGMIGLIFNTLSAYQNESMRQLTVATIIFLPLTFLTGYFGQNFEPFSVLQEDISYLYALPPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H792</accession>
    <name>Q2H792_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221568.1">
        <property type="nucleotide sequence ID" value="XM_001221567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H792"/>
    <dbReference type="GeneID" id="4390984"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05473"/>
    <dbReference type="HOGENOM" id="CLU_1348776_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H792"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="203" mass="19467" checksum="F1A7EB2F93D62EC7" modified="2006-03-21" version="1">MPSQPPSTHHLPHPHPHPPLTKPSPMRNLSEYAVADTPGTAGPEYAATGGGAGGGGGGGGGDYLQCRFVPICSPVSTPGVGGVGAQGVQGVQGTGGGGGGGAAAAGWGGDVDAGADGDGDADVGVDMQREMGVRRDPEGKGAGGGAEGGTVRARARRGSMSVGGDGGGSGVVRPGMRRESPGGFHGRGRGEVTLGAGEADLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H796</accession>
    <name>Q2H796_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221564.1">
        <property type="nucleotide sequence ID" value="XM_001221563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H796"/>
    <dbReference type="STRING" id="306901.Q2H796"/>
    <dbReference type="GeneID" id="4391043"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05469"/>
    <dbReference type="eggNOG" id="ENOG502R6CU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042688_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H796"/>
    <dbReference type="OMA" id="TGHEARF"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="227" mass="26032" checksum="93B1CDF501C2C70F" modified="2006-03-21" version="1">MRQDLDEEFCGLDLPTVQPESFHHLAPLERYHSEKPYKCQLPNECFPGLEMHNLVSKSYRVSISDITGHEARFSLPVSGFEFAKSPVTVQNWSDDYVLSEYLPGLVEWLTQRLGCRGVFCYAYNVRPHRWGGAGAAGGIDHSVWRPISPAPVEDCPLALCDFRTVDRDDLVPMDIVYPHFIDEAYEVKYNPSHRWFYKRGMTQDDVIVFKLYDSMKSEATGKSNTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7C9</accession>
    <name>Q2H7C9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GmrSD restriction endonucleases C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221531.1">
        <property type="nucleotide sequence ID" value="XM_001221530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7C9"/>
    <dbReference type="STRING" id="306901.Q2H7C9"/>
    <dbReference type="GeneID" id="4390291"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05436"/>
    <dbReference type="eggNOG" id="ENOG502QWPZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043034_3_1_1"/>
    <dbReference type="InParanoid" id="Q2H7C9"/>
    <dbReference type="OMA" id="ASYYCTY"/>
    <dbReference type="OrthoDB" id="3162605at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="GmrSD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24094:SF15">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24094">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="GmrSD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208595" description="GmrSD restriction endonucleases C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="GmrSD restriction endonucleases C-terminal" evidence="2">
        <location>
            <begin position="99"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="204" mass="22054" checksum="2912B9874B0D2445" modified="2006-03-21" version="1">MKSYILGSLLAVAVSAIPMPAPTPPGIPSASTAKSQLAALTVKASYDDGAYSREKFPHWQTASGTCNTREYVLKRDGSNVVTNDACTATSGTWFSPYDGATWTAASDVDIDHMVPLKNAWISGANSWSTAKRTQFANDIDIPQLWAVTDNVNQAKSDQSPDKWKPPLSSFYCTYSKSWVNVKYSYGLSITSAEKSALTSMLNSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7R2</accession>
    <name>Q2H7R2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221398.1">
        <property type="nucleotide sequence ID" value="XM_001221397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7R2"/>
    <dbReference type="STRING" id="306901.Q2H7R2"/>
    <dbReference type="GeneID" id="4391487"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05303"/>
    <dbReference type="eggNOG" id="ENOG502S2GX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067875_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7R2"/>
    <dbReference type="OMA" id="YDVDCDC"/>
    <dbReference type="OrthoDB" id="2533647at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="21"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="241" mass="27273" checksum="8533207B8644EBAB" modified="2006-03-21" version="1">MTSPVDPHSKCYSHINGTANDLSDRLAVSELCKGWPVYRDASEWQNYRDLFAEDATVWTTWSGPQPVDDFIAISKAGKEKGVFIMHRECGTLVELASNNNRAIGKMKATITHRFKFDPTTGGNGASPDTETAEFDVDCDCRFIFFCEKNAETRQWKAKYVKLFYEKDKVVPTDGRTAPVFSKEELEKIPTGYKYLGAAQARLGYRIDLDLPTAGGELFTRMYGEMEKWLDGKSVDLFWEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H807</accession>
    <name>Q2H807_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230163.1">
        <property type="nucleotide sequence ID" value="XM_001230162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H807"/>
    <dbReference type="STRING" id="306901.Q2H807"/>
    <dbReference type="GeneID" id="4388995"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03647"/>
    <dbReference type="eggNOG" id="ENOG502SGSI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152075_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H807"/>
    <dbReference type="OMA" id="FAGIPKM"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="107" mass="10891" checksum="4FE0F2906587228E" modified="2006-03-21" version="1">MAVTSAITDLVKSVVELLSSVFSAAYAIVHSFVSGVLGLFAGFFAFVGDLGQGVFDLAGGVGKFVAGNAAILAALAAAYYAYVRFAQQPQQGRKPAVTNGAGVKKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H898</accession>
    <name>Q2H898_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230072.1">
        <property type="nucleotide sequence ID" value="XM_001230071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H898"/>
    <dbReference type="STRING" id="306901.Q2H898"/>
    <dbReference type="GeneID" id="4388384"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03556"/>
    <dbReference type="eggNOG" id="ENOG502QVBV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032618_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H898"/>
    <dbReference type="OMA" id="WVRARCW"/>
    <dbReference type="OrthoDB" id="1896086at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="LIPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18647">
        <property type="entry name" value="Fungal_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208617" description="SGNH hydrolase-type esterase domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="55"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="645" mass="72436" checksum="387F26529403A3B2" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8H1</accession>
    <name>Q2H8H1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_03483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229999.1">
        <property type="nucleotide sequence ID" value="XM_001229998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8H1"/>
    <dbReference type="GeneID" id="4389278"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03483"/>
    <dbReference type="HOGENOM" id="CLU_3384696_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8H1"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ91548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="33" mass="3570" checksum="9D7F7668334878E7" modified="2006-03-21" version="1">MTVHTRNPALLLFNLLAQKKTNPMTATPTTGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8L5</accession>
    <name>Q2H8L5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_03439</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229955.1">
        <property type="nucleotide sequence ID" value="XM_001229954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8L5"/>
    <dbReference type="STRING" id="306901.Q2H8L5"/>
    <dbReference type="GeneID" id="4389471"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03439"/>
    <dbReference type="eggNOG" id="ENOG502SKH5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_8_4_1"/>
    <dbReference type="InParanoid" id="Q2H8L5"/>
    <dbReference type="OMA" id="FFMCNFL"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF30">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="4"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ91504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="305" mass="32605" checksum="1C5E6624B22570F7" modified="2006-03-21" version="1">MTNPTVFVCGATGAQGGRLAHRLRAIGWGVHTTVRDPSSPAAQSLQSIGVETTPGDWNNEAALAHSLTGCQMLFLNPVPPPLPRHPPRTCNQAQTLLRLALAAHIHHVVYSSSIPLPTTDPTSLPALARASKRHIETATRSAGIPVWTILRPAFFMTNLVRPNVDRLFPGASATGEFTLALRPDTPLALIDPDDIAQFAVAAFRAPGRFHGQVVDLAGEVRAVGEVLAVLAGVVGRGVRGRYLREEEVEERKGVEVFLSGQLDLKEAAPVDVGRVRSWGVEMGTLEGELVLGDEVGWKDDAGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8W7</accession>
    <name>Q2H8W7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229853.1">
        <property type="nucleotide sequence ID" value="XM_001229852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8W7"/>
    <dbReference type="STRING" id="306901.Q2H8W7"/>
    <dbReference type="GeneID" id="4389492"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03337"/>
    <dbReference type="eggNOG" id="ENOG502T0JZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012330_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8W7"/>
    <dbReference type="OMA" id="GPRMILP"/>
    <dbReference type="OrthoDB" id="4760831at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="577"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="785"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="844"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="877"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="851"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="902"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="916"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="935"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="946" mass="107015" checksum="7A135649F7B33671" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8Y0</accession>
    <name>Q2H8Y0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MICOS complex subunit MIC10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_03324</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Mitochondrion inner membrane</location>
            <topology evidence="2 9">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the MICOS complex subunit Mic10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229840.1">
        <property type="nucleotide sequence ID" value="XM_001229839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8Y0"/>
    <dbReference type="FunCoup" id="Q2H8Y0">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H8Y0"/>
    <dbReference type="GeneID" id="4389572"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03324"/>
    <dbReference type="eggNOG" id="KOG4604">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068905_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H8Y0"/>
    <dbReference type="OMA" id="SNCRHDL"/>
    <dbReference type="OrthoDB" id="1916310at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140260">
        <property type="term" value="F:mitochondrial proton-transporting ATP synthase complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097753">
        <property type="term" value="P:membrane bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007512">
        <property type="entry name" value="Mic10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304:SF0">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04418">
        <property type="entry name" value="DUF543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ91389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="90" mass="9828" checksum="274F93B07BD36EAF" modified="2006-03-21" version="1">MAETATPPAPTRAVSRPVSEALLNEKWDRCLSNLIIKSSLGLGFGVVFSVLIFRRRAWPAFVGVGFGAGRAYEECNYSLKAAARDIRKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9Y8</accession>
    <name>Q2H9Y8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_02966</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229482.1">
        <property type="nucleotide sequence ID" value="XM_001229481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9Y8"/>
    <dbReference type="STRING" id="306901.Q2H9Y8"/>
    <dbReference type="GeneID" id="4389718"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02966"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_2_1"/>
    <dbReference type="InParanoid" id="Q2H9Y8"/>
    <dbReference type="OMA" id="AVKEIYC"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF164">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209082" description="Cytochrome P450" evidence="5">
        <location>
            <begin position="19"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ91031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="49222" checksum="AA2C6FDE14F4E05F" modified="2006-03-21" version="1">MLSPLLISLVVFLLAVHALRQRLTSPLNKIPGPWHAKFTTLVLKWHEFRTNRTRYVHHLHLKYGPTVRIAPNEVVFASAAAVKEIYCSGGSGYDKTEFYDMFKVYGRRTMFTTLNKDDVRPFPSHHRYANTNVVRPQSLDGIADRAGNFVKKCFQSVGGSLDLYINRLFQFYWPTAHKILGQVLYLFAKPRETPLADDFVLDTCALTDTAPFTLLNRLQGPNYHLDALDIAAECLDHMAAGIDTTGDALCFLMWELSQPASMPYQRALQRELLAHPGASFDRLPYLDAVVLEGLRCFPAIPMSLPRYVPGGGRTIDGFFLPQGTTVSCQAYSVQRMDGEVFPEPDAFRPERWLEPKGDAERKRLFFAFANGGRGCVGKHLALAEMKLLLQAVYSRFTTLPDASMTAAGMEMSDQLISSRPAGQRCLLRFDPLEAMSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HA24</accession>
    <name>Q2HA24_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA splicing factor ini1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229446.1">
        <property type="nucleotide sequence ID" value="XM_001229445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HA24"/>
    <dbReference type="FunCoup" id="Q2HA24">
        <property type="interactions" value="818"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HA24"/>
    <dbReference type="GeneID" id="4388405"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02930"/>
    <dbReference type="eggNOG" id="KOG1705">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110369_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HA24"/>
    <dbReference type="OMA" id="AYYCWEC"/>
    <dbReference type="OrthoDB" id="10248186at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005345">
        <property type="entry name" value="PHF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13120">
        <property type="entry name" value="PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03660">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016468">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="12275" checksum="3A9D88C9EB2B1285" modified="2006-03-21" version="1">MSRHHPDLVMCRKQSGIAIGRLCDKCDGKCPVCDSYVRPTTLVRICDECSFGNYQNKCVVCGGEGISDAFYCFECTRLEKDRDGCPKIINLGSSRTDLFYQKKTNRTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAK3</accession>
    <name>Q2HAK3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_02751</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229267.1">
        <property type="nucleotide sequence ID" value="XM_001229266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAK3"/>
    <dbReference type="FunCoup" id="Q2HAK3">
        <property type="interactions" value="378"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HAK3"/>
    <dbReference type="GeneID" id="4389014"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02751"/>
    <dbReference type="eggNOG" id="KOG0438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_723609_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HAK3"/>
    <dbReference type="OrthoDB" id="268576at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000034">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="5">
        <location>
            <begin position="151"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ90816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="382" mass="41346" checksum="E7F8851D4476C7F7" modified="2006-03-21" version="1">MLQPRLRPLVAGVASLPSLCQRALQLNTIRRYAAVVPGDVKNTPGEDGSAGFGPPSTQIEAVKMRTYKPRTPGLRHLKRPINDHLWKGRPYLPLTIPKKREQATGNKTYIVAAEGMRAGDVVQSYRAGIPQDLLDSMGGVIDPGILAAKTAWRGNCLPMHMIPVGTVVYNVGSRMDGGAVFCRSAGTYATIISKEEETRDDGTKVMTGKHVVVRLQSGEIRKVSKDACATIGVASNIMHQYRQLGKAGRSRLLNIRPTVRGLAMNATGSGLMSNPLLECSPTQRQSRDICGLDWGHAVALALRIVFKPSPSQPQPARRLVRIPDIATPCGVQGSRRASAEAPQLTGAYQFGGKPRGQGSAVREFSALTNGVRWTRQERSDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAU3</accession>
    <name>Q2HAU3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229177.1">
        <property type="nucleotide sequence ID" value="XM_001229176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAU3"/>
    <dbReference type="GeneID" id="4389465"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02661"/>
    <dbReference type="HOGENOM" id="CLU_2026452_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HAU3"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13844" checksum="EC8640BD1A72280B" modified="2006-03-21" version="1">MRISLPLAQRQLHTLPSLLLLLLRGPRFLLIQTHGLHPGRWGQAPWRRQKVIREKRMLWYESSACSSRRMREVVVVVVVVVVVVVVVVVVVVVVVVVGVVVVASSSSKGRRSKKRLARARLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HB56</accession>
    <name>Q2HB56_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">guanosine-diphosphatase</fullName>
            <ecNumber evidence="5">3.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_02548</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.42" evidence="5"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229064.1">
        <property type="nucleotide sequence ID" value="XM_001229063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HB56"/>
    <dbReference type="FunCoup" id="Q2HB56">
        <property type="interactions" value="325"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HB56"/>
    <dbReference type="GeneID" id="4389394"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02548"/>
    <dbReference type="eggNOG" id="KOG1385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010246_4_0_1"/>
    <dbReference type="InParanoid" id="Q2HB56"/>
    <dbReference type="OMA" id="WTCRIKE"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24040">
        <property type="entry name" value="ASKHA_NBD_GDA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="273"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ90613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="550" mass="60075" checksum="292C090586C7D4F3" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBK5</accession>
    <name>Q2HBK5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phenylalanine ammonia-lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAL/histidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228915.1">
        <property type="nucleotide sequence ID" value="XM_001228914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBK5"/>
    <dbReference type="STRING" id="306901.Q2HBK5"/>
    <dbReference type="GeneID" id="4389748"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02399"/>
    <dbReference type="eggNOG" id="KOG0222">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014801_3_1_1"/>
    <dbReference type="InParanoid" id="Q2HBK5"/>
    <dbReference type="OMA" id="GNFHGDY"/>
    <dbReference type="OrthoDB" id="10051290at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.20">
        <property type="entry name" value="Phenylalanine ammonia-lyase 1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023144">
        <property type="entry name" value="Phe_NH3-lyase_shielding_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="706" mass="74716" checksum="580ADFFE8ACD6778" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBT6</accession>
    <name>Q2HBT6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_02318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228834.1">
        <property type="nucleotide sequence ID" value="XM_001228833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBT6"/>
    <dbReference type="STRING" id="306901.Q2HBT6"/>
    <dbReference type="GeneID" id="4388481"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02318"/>
    <dbReference type="eggNOG" id="ENOG502S3V7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038504_2_1_1"/>
    <dbReference type="InParanoid" id="Q2HBT6"/>
    <dbReference type="OrthoDB" id="5593235at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ90383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="473" mass="52256" checksum="1DD173F9E5D25EE2" modified="2006-03-21" version="1">MGDFSTSGDGGIITARLDDVAPADYSHSLASGNFFAMSSRGFKIPLSMHWVAVYAFALVSLFGVYLLSFSDIGYFRDDHTAVEGTPNVPAAQPPPATAPLNPALNSPNAPSTSTTPASDTNKGAGDHVETLDPPQPGQMIFAINTDIKEDLDYLNNELLSFPLLPQVSGQRAPVTWASVVGPSTSATPSMSQIDGQRTWSSSRMIRLASVVQPLVDNPSYFAVSANVVNNPALSWVHYHLGVFEPYWPEMKKPWTPSSESSWRASELPSYKGPADGPDGFKIDGSTPAPFPGHRWLPVRHKNKDEYEDPTKFPASTLTYDAHGPSLDNWATAAQLHYSFFQHLENNETSLYKFGIWDYHYARISINFIALRGGDIMDAYPFPHSDDEKFLTVEHSRKLGKHVVVAGDGLAVHYAFRPQRRAHDGHGITDTDILRRYTAYAKELVCPFPKREVKAPPLLRTEQNRRRKGPGRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HC19</accession>
    <name>Q2HC19_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S33 tripeptidyl aminopeptidase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_02235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228751.1">
        <property type="nucleotide sequence ID" value="XM_001228750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HC19"/>
    <dbReference type="STRING" id="306901.Q2HC19"/>
    <dbReference type="ESTHER" id="chagb-q2hc19">
        <property type="family name" value="AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="4388984"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02235"/>
    <dbReference type="eggNOG" id="ENOG502RZ4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013364_5_0_1"/>
    <dbReference type="InParanoid" id="Q2HC19"/>
    <dbReference type="OMA" id="FQSAPYY"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209052" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="3">
        <location>
            <begin position="391"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ90300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="532" mass="57227" checksum="EBD04AA341A71431" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HC43</accession>
    <name>Q2HC43_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_02211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228727.1">
        <property type="nucleotide sequence ID" value="XM_001228726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HC43"/>
    <dbReference type="GeneID" id="4389501"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02211"/>
    <dbReference type="HOGENOM" id="CLU_2722005_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HC43"/>
    <dbReference type="OrthoDB" id="10671914at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ90276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="72" mass="7538" checksum="8B8379A9153F6E86" modified="2006-03-21" version="1">MTMPEGEAAKVLGIAAAGAGGAISPQLEHVDASEMMESRDALLQAIRDIDVRLAKLEVADSGSADYIIARRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCC6</accession>
    <name>Q2HCC6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_02128</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221349.1">
        <property type="nucleotide sequence ID" value="XM_001221348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCC6"/>
    <dbReference type="GeneID" id="4386382"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02128"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="InParanoid" id="Q2HCC6"/>
    <dbReference type="OMA" id="SMEGGIM"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000037">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF168">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="72"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ93893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="486" mass="52004" checksum="B17B7C6D5DD9E00F" modified="2006-03-21" version="1">MDTKSPTPRDAEAGNDAFVMSPPLENHALSMRSHNILILIVSNTPVLRWERVDGESREDGGMGHRGLGFWRCFTGLCIPILLSAFEGSVVSTALPTISRSLNLGPNSSWVATAFLLASIIFQPLFGQLADIWGRRHLMMIAVVIFGAGSAIAGYANNCAVLVFGRIIQGIGSGGIDLFAELILCDIIPLKKRGHYVAIKAAVYALGTTVGPLLGGVFAQTNWRWCFGVNLPICIIALVLMWFWLQLSSGHSWKGLTALQQIGQVDFVGISLLTTAVVLILCALSLAGTVYSWSHPTIVASLAGGFAGTVAFIFWQRSRRCARPIMAPHVFSNRTTIAALAITALHGFITYGFQFYLPPFFQAVLGASPSQSGLLILPCSLAVVILASVGGPLLARFGKYRLMHLVGFVLMIAGILPCITFEKSRSVGLWIFMSLLVGIGSGVIVSTTLPTVLVELTDKENAAATGSWAFLRGLGSLLGVALPNSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HD49</accession>
    <name>Q2HD49_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Delta(24)-sterol reductase</fullName>
            <ecNumber evidence="2">1.3.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_01855</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
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            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDE6</accession>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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            <end position="1006"/>
        </location>
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        </location>
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            <end position="1082"/>
        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1193" mass="128647" checksum="C65AD2469B439B54" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDR1</accession>
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            <fullName evidence="5">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="4387745"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01643"/>
    <dbReference type="eggNOG" id="ENOG502QW68">
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    </dbReference>
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    <dbReference type="InParanoid" id="Q2HDR1"/>
    <dbReference type="OMA" id="FPDAVMG"/>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021822">
        <property type="entry name" value="DUF3405"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11885">
        <property type="entry name" value="DUF3405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="233"/>
        </location>
    </feature>
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        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
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        <location>
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            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
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        </location>
    </feature>
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        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="873" mass="99196" checksum="B5F1907A6A2F9A23" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HE42</accession>
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        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220733.1">
        <property type="nucleotide sequence ID" value="XM_001220732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HE42"/>
    <dbReference type="GeneID" id="4388161"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01512"/>
    <dbReference type="eggNOG" id="ENOG502QS3B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003963_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HE42"/>
    <dbReference type="OMA" id="NPYPEYH"/>
    <dbReference type="OrthoDB" id="2419400at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000028">
        <property type="entry name" value="WW domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF2">
        <property type="entry name" value="WW DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06520)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="512"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1255" mass="134399" checksum="1B39145B64AD7A33" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEM3</accession>
    <name>Q2HEM3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220552.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEM3"/>
    <dbReference type="GeneID" id="4387297"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01331"/>
    <dbReference type="HOGENOM" id="CLU_1510413_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HEM3"/>
    <dbReference type="OrthoDB" id="4589745at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208857" evidence="2">
        <location>
            <begin position="24"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="178" mass="18296" checksum="EB2EA662D522A574" modified="2006-03-21" version="1">MIILSAVLFLIIAALIVVSSILGTKIAKLENTISPLAVAVAESAANGTTTNNNNNNNNNNNPYTTTTSSPVNNLNPSQTSSTTTSSTAPPPAPLPPTIQVAGWTYLGCFYDSERGGQAAAALWHAGGGAVLLRDGDAGGAGEPARARLDVHAPVCGPVGDVGELWRELGAEFVERDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HER3</accession>
    <name>Q2HER3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_01291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220512.1">
        <property type="nucleotide sequence ID" value="XM_001220511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HER3"/>
    <dbReference type="GeneID" id="4388224"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01291"/>
    <dbReference type="eggNOG" id="ENOG502T5AP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_844673_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HER3"/>
    <dbReference type="OrthoDB" id="10457425at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ93056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="329" mass="36642" checksum="62AD3521B5E87ED3" modified="2006-03-21" version="1">MEDLTDALMGTIKKNNLYLKSGVADEMWKCVLERQPEPGVDGEATCTVKHSEPYGAMSPDIVKHFSGNPKFSKYFTYDYPTKRMALRAEYCRETAGFTDAMTQIMTVMRSLRRPGPFGSLRACEDIRMANGVSQEEYTLPVILASMLGVVTEEVGMNVYSETDDGKIMIRVNPVPIFSVEPDPELDAEIGPEADFFDDLAESGVCCPHLTTVSFGNFTHNRDLRIDRPVFGIARVFHLKGNGNIPNDKGDGFEWMTLEEVRTALVAREFTPAAELVMLDFLHRHDMLGISMSDEQKKVMEDALHPLKDMQQAFAGAFPDVSMIGNGSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEU7</accession>
    <name>Q2HEU7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_01257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220478.1">
        <property type="nucleotide sequence ID" value="XM_001220477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEU7"/>
    <dbReference type="GeneID" id="4386890"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01257"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_436770_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HEU7"/>
    <dbReference type="OrthoDB" id="10470150at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ93022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="626" mass="69794" checksum="7621769291314919" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HF50</accession>
    <name>Q2HF50_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_01154</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220375.1">
        <property type="nucleotide sequence ID" value="XM_001220374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HF50"/>
    <dbReference type="STRING" id="306901.Q2HF50"/>
    <dbReference type="GeneID" id="4387476"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01154"/>
    <dbReference type="eggNOG" id="ENOG502SYFF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1834929_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HF50"/>
    <dbReference type="OMA" id="CHCGIVQ"/>
    <dbReference type="OrthoDB" id="2993351at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ92919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="140" mass="15627" checksum="31B63655AE4FB20E" modified="2006-03-21" version="1">MSQEEGKIPEGTSPPQKEADGKSSGTYEGGCHCGYIKFSVTLTPALPETKVLNCNCSACRRFGYLLVYKDQMFCKHCGASIGIDFREVHAPEHIYGISVRTFFDIDLDSLTYRKLDGRNRVPPAGDLSGQYWDEEAHKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFC4</accession>
    <name>Q2HFC4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar transporter chaperone complex subunit 4</fullName>
            <ecNumber evidence="3">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Polyphosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">SPX-dependent polyphosphate polymerase VTC subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Vacuolar membrane polyphosphate polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_01080</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19574"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the VTC4 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="3"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220301.1">
        <property type="nucleotide sequence ID" value="XM_001220300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFC4"/>
    <dbReference type="FunCoup" id="Q2HFC4">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HFC4"/>
    <dbReference type="GeneID" id="4387491"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01080"/>
    <dbReference type="eggNOG" id="KOG1161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009308_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HFC4"/>
    <dbReference type="OMA" id="NVNAYMR"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07751">
        <property type="entry name" value="PolyPPase_VTC4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.30:FF:000001">
        <property type="entry name" value="Vacuolar transporter chaperone 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="687"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="717"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="759"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="17">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="521"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="526"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="547"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ92845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="784" mass="89666" checksum="2F9CC5DE1D9B600F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFF0</accession>
    <name>Q2HFF0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220275.1">
        <property type="nucleotide sequence ID" value="XM_001220274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFF0"/>
    <dbReference type="GeneID" id="4386792"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01054"/>
    <dbReference type="eggNOG" id="ENOG502SGHJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_284285_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HFF0"/>
    <dbReference type="OMA" id="TVKCPWC"/>
    <dbReference type="OrthoDB" id="5386674at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="599"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="630"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="917"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1137" mass="122645" checksum="8240093A82ADABE1" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFI7</accession>
    <name>Q2HFI7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_01017</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220238.1">
        <property type="nucleotide sequence ID" value="XM_001220237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFI7"/>
    <dbReference type="STRING" id="306901.Q2HFI7"/>
    <dbReference type="GeneID" id="4387520"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01017"/>
    <dbReference type="eggNOG" id="KOG1430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045580_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HFI7"/>
    <dbReference type="OMA" id="HDQFFGN"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000252">
        <property type="term" value="F:3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF447">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE_ISOMERASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06450)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208898" description="3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="5">
        <location>
            <begin position="71"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ92782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="482" mass="52880" checksum="42C1CBAAB6BA9549" modified="2006-03-21" version="1">MFWVVIAAVAVIASAWLARINSAMKSVPEDVQKISPRRWTKDQLRNVYQRVRQNPIDYARLLPPRLNRRYVVVGGSGLVGGDIVLQLLQRGESPESIRVVDFVPLNRRDMVKTAAGCDFVKADITSRSSVEAAFSKPWPKSVAKLPLTVFHTAAAVRPQERNPLFYHRISSVNRDGAVNVLETARDAGADILIATSSASVSIVPPSFWIWPWQSNPKRYYQIANEKDFDAPLRAHDLFFSNYARSKAEAERAVCGANEDGFRTGTIRPGNPIYGQKTDPVIGILLRLGDNVTWIPHVVQHFVNSRNVALSHLQFEAALARKDAPMPACAGRTFNVTDVGPPITFADIYEAGEHLSVTRVRDKRQSPLALLLVAYAIEAWCLLLARLPFLTTVFGLREPSGPIHMLQPAIFSVSIHTVIDDSAARKSVADGGFGYQGACTTIEGVCEQIVEWNREHEDAAEEVGGAPDGKLAKAALTGKGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFJ9</accession>
    <name>Q2HFJ9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_01005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220226.1">
        <property type="nucleotide sequence ID" value="XM_001220225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFJ9"/>
    <dbReference type="STRING" id="306901.Q2HFJ9"/>
    <dbReference type="GeneID" id="4387456"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01005"/>
    <dbReference type="eggNOG" id="KOG2451">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HFJ9"/>
    <dbReference type="OMA" id="PFGGEKH"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07105">
        <property type="entry name" value="ALDH_SaliADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000010">
        <property type="entry name" value="Gamma-aminobutyraldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000012">
        <property type="entry name" value="NAD-dependent succinate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF6">
        <property type="entry name" value="CYTOPLASMIC ALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="28"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ92770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="484" mass="51709" checksum="24EB3108F905A739" modified="2006-03-21" version="1">MSAPATAPPTEGAPVPFFINGKEVHPERRFKVVAPATGEVVHESASASEADVRAAIDTAADAFRTWKKALPSVRRNILLKAAEVMERRKEELGGYMMIETGCPRQWADFNVDAAKELILDVAGRVATLDGSLPTTRDAGTGAMVINEPFGVVLAIAPWNAPYILGVRSILFPIGAGNAAILKGSELCPRTMWGLCSVFHEAGLPDGVLNLLFHEPANAAAITQMLIADPQIKKINFTGSTIVGRIIGRLAGEHLKPVLLELGGKAPAIVWEDADLDNAAVQCALGAFLNSGQICMSTERILVHKAVRAAFEAKLTSAIDHIFGGQKDAPVLINSVGVTKNKKLVEDALAKGASLLYGDLAAQESTPTRMRPIVVSGATTDMDIYKTESFGPTVSLYEIETEEEALRIANDTEYGLSSAVFTEDLRRGLRFAKEIETGAVHINSMSVHDESALPHGGAKASGYGRFNAGLGLSEWVRTKTITFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFQ5</accession>
    <name>Q2HFQ5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_00949</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
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    <sequence length="1866" mass="203566" checksum="458DD01758975E47" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
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        </recommendedName>
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        </lineage>
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
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            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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    </dbReference>
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            <end position="66"/>
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        <location>
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        <location>
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        </location>
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        </location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ92689.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1377" mass="149874" checksum="F45567EA896C70DC" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG45</accession>
    <name>Q2HG45_CHAGB</name>
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        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="13" type="ORF">CHGG_00809</name>
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    <organism evidence="13 14">
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
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        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
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    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001220029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG45"/>
    <dbReference type="FunCoup" id="Q2HG45">
        <property type="interactions" value="288"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HG45"/>
    <dbReference type="GeneID" id="4386262"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00809"/>
    <dbReference type="eggNOG" id="KOG4645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001999_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HG45"/>
    <dbReference type="OMA" id="CYALEYQ"/>
    <dbReference type="OrthoDB" id="1043025at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
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        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="1007"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="1036"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ92574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1152" mass="129973" checksum="1930EFC37E56E2D0" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG91</accession>
    <name>Q2HG91_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_00763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219984.1">
        <property type="nucleotide sequence ID" value="XM_001219983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG91"/>
    <dbReference type="GeneID" id="4386731"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00763"/>
    <dbReference type="HOGENOM" id="CLU_2426809_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HG91"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ92528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="91" mass="9624" checksum="59796D9248215747" modified="2006-03-21" version="1">MAGITSRSAASLPIGVGIGSVDVYSPAFSRRLTQGFIPNLLVRGEKGAGERSEVLSVEHKVILEEIVGRVTQPAAQNQNAMRKEPGQTPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGA1</accession>
    <name>Q2HGA1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_00753</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219974.1">
        <property type="nucleotide sequence ID" value="XM_001219973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGA1"/>
    <dbReference type="GeneID" id="4386674"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00753"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_4_3_1"/>
    <dbReference type="InParanoid" id="Q2HGA1"/>
    <dbReference type="OMA" id="AAYQMSQ"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF26">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_4G05870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ92518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="32620" checksum="04072A80FBF313C4" modified="2006-03-21" version="1">MTSKPQFESGHEIPVSGQSFPGLESKMPNPQPLFDEIPTEDGKSQKYKPAEKLKGKKAIITGGDSGIGRATAILFAMEGADSLIAYLPEEEEDARETKKRVEQYGQQCHLLATDLRDKENCKRVVDEAVKVFGGKLDILFNNAAYQMVVDDIKDLSEDQWLHTFNTNIHPYFFLAKYALPHMKRGSTIVNNASINAYVGRPDLLDYTSTKGAIVSFTRGLSNQQVGKGIRVNAIAPGPVWTPLIPSTMPDKAQKQFTSPMGRPSQPSEIATCVVFLASLDSSSISGQTIHCNGGSIVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGW1</accession>
    <name>Q2HGW1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Multicopper oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_00543</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219764.1">
        <property type="nucleotide sequence ID" value="XM_001219763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGW1"/>
    <dbReference type="GeneID" id="4388076"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00543"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_7_3_1"/>
    <dbReference type="InParanoid" id="Q2HGW1"/>
    <dbReference type="OMA" id="FHGINQI"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208946" description="Multicopper oxidase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="30"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="163"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="362"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ92308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="598" mass="66510" checksum="D27B019A877607E1" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGX7</accession>
    <name>Q2HGX7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcofluor white hypersensitive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_00527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219748.1">
        <property type="nucleotide sequence ID" value="XM_001219747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGX7"/>
    <dbReference type="GeneID" id="4387880"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00527"/>
    <dbReference type="eggNOG" id="ENOG502SSX2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129945_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HGX7"/>
    <dbReference type="OMA" id="KHQMRID"/>
    <dbReference type="OrthoDB" id="5355126at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ92292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14018" checksum="59E6D1B65E1E2E57" modified="2006-03-21" version="1">MSRSRAPLAIGLAAAGGVGYYLYSAGGSPRAAEKQFESDAHHVAAKIKGEVPHRSTNLEQEGRKAGKELGAKVDNAVETVNRDISKARSETEAYAKSAKADTLKKIDEFDRKVEDGAAKSKSYVSSWFGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH27</accession>
    <name>Q2HH27_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219698.1">
        <property type="nucleotide sequence ID" value="XM_001219697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH27"/>
    <dbReference type="STRING" id="306901.Q2HH27"/>
    <dbReference type="GeneID" id="4387791"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00477"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_15_3_1"/>
    <dbReference type="InParanoid" id="Q2HH27"/>
    <dbReference type="OrthoDB" id="4589250at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="140" mass="15337" checksum="9F2542B915024FB2" modified="2006-03-21" version="1">MPPHSSHKLQPADVGCFSPLKAAYGKQIEEMMRASITHITKEDFFPAFLAAHQATMTYDNIRGGFRGAGLVPFYPEEVISQLDIRLKTPTPPNSRPGSAYAWVSKTPNNPIEASSQTTLIKTWIAQHQNSSPTSLLAAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHS3</accession>
    <name>Q2HHS3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219452.1">
        <property type="nucleotide sequence ID" value="XM_001219451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHS3"/>
    <dbReference type="STRING" id="306901.Q2HHS3"/>
    <dbReference type="GeneID" id="4388259"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00231"/>
    <dbReference type="eggNOG" id="ENOG502RUHV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_7_0_1"/>
    <dbReference type="InParanoid" id="Q2HHS3"/>
    <dbReference type="OMA" id="WVPDFSF"/>
    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="162"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="771" mass="86943" checksum="CB3D8702FA8D41DF" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI86</accession>
    <name>Q2HI86_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6603 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219289.1">
        <property type="nucleotide sequence ID" value="XM_001219288.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HI86"/>
    <dbReference type="GeneID" id="4386583"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00068"/>
    <dbReference type="eggNOG" id="ENOG502R9QD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001050_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HI86"/>
    <dbReference type="OMA" id="PFDEMYL"/>
    <dbReference type="OrthoDB" id="5352492at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046538">
        <property type="entry name" value="DUF6603"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20248">
        <property type="entry name" value="DUF6603"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6603" evidence="2">
        <location>
            <begin position="904"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6603" evidence="2">
        <location>
            <begin position="1218"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="881"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1609"/>
            <end position="1631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1679" mass="180872" checksum="CCE251FBE8F39589" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>P0CU31</accession>
    <accession>Q2HEW2</accession>
    <name>CHEE_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome P450 monooxygenase cheE</fullName>
            <ecNumber evidence="8">1.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Chaetoglobosin A biosynthesis cluster protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cheE</name>
        <name type="ORF">CHGG_01242-1</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2013" name="J. Am. Chem. Soc." volume="135" first="7371" last="7377">
            <title>Combinatorial generation of complexity by redox enzymes in the chaetoglobosin A biosynthesis.</title>
            <authorList>
                <person name="Ishiuchi K."/>
                <person name="Nakazawa T."/>
                <person name="Yagishita F."/>
                <person name="Mino T."/>
                <person name="Noguchi H."/>
                <person name="Hotta K."/>
                <person name="Watanabe K."/>
            </authorList>
            <dbReference type="PubMed" id="23611317"/>
            <dbReference type="DOI" id="10.1021/ja402828w"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2021" name="Fungal Biol." volume="125" first="201" last="210">
            <title>Functional analysis of a chaetoglobosin A biosynthetic regulator in Chaetomium globosum.</title>
            <authorList>
                <person name="Cheng M."/>
                <person name="Zhao S."/>
                <person name="Liu H."/>
                <person name="Liu Y."/>
                <person name="Lin C."/>
                <person name="Song J."/>
                <person name="Thawai C."/>
                <person name="Charoensettasilp S."/>
                <person name="Yang Q."/>
            </authorList>
            <dbReference type="PubMed" id="33622536"/>
            <dbReference type="DOI" id="10.1016/j.funbio.2020.10.010"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5 9">Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of chaetoglobosin A which has a unique inhibitory activity against actin polymerization in mammalian cells (PubMed:23611317, PubMed:33622536). Chaetoglobosin A and its intermediates are involved in the morphological differentiation of C.globosum (PubMed:33622536). The first step of the pathway is the synthesis of prochaetoglobosin I via condensation of one acetyl-CoA, 8 malonyl-CoA, and a L-tryptophan molecule by the PKS-NRPS hybrid synthetase cheA, followed by reduction of backbone double bond to install desired geometry by the enoyl reductase cheB (PubMed:23611317). Further multiple oxidation steps performed by the cytochrome P450 monooxygenases cheE and cheG, as well as by the FAD-linked oxidoreductase cheF, lead to the formation of chaetoglobosin A (PubMed:23611317). Depending on the order of action of these reductases, distinct intermediates can be identified (PubMed:23611317). Within the pathway, the cytochrome P450 monooxygenase cheE catalyzes a stereospecific epoxidation on prochaetoglobosin I, cytoglobosin D, and chaetoglobosin J intermediates (PubMed:23611317). The FAD-linked oxidoreductase cheF performs dehydrogenation of the C-20 hydroxyl groups in the 20-dihyrochaetoglobosin A and cytoglobosin D intermediates (PubMed:23611317). Finally, the cytochrome P450 monooxygenase cheG can catalyze the stereospecific dihydroxylation of prochaetoglobosin I and prochaetoglobosin IV at C-19 and C-20, respectively (PubMed:23611317). The Diels-Alderase cheD may play a role in the post-PKS-NRPS biosynthetic steps catalyzing Diels-Alder cyclization.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">Expression is positively regulated by the cluster-specific transcription factor cheR that binds directly to an asymmetric direct repeat present in the promoter.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Impairs the production of chaetoglobosin A but leads to the accumulation of cytoglobosin D and chaetoglobosin J (PubMed:23611317).</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAQ93007" version="1"/>
        </conflict>
        <text>The predicted gene CHGG_01242 has been split into 2 genes: CHGG_01242-1 and CHGG_01242-2.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93007.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0CU31"/>
    <dbReference type="SMR" id="P0CU31"/>
    <dbReference type="STRING" id="306901.P0CU31"/>
    <dbReference type="GlyCosmos" id="P0CU31">
        <property type="glycosylation" value="5 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01242"/>
    <dbReference type="InParanoid" id="P0CU31"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019771">
        <property type="entry name" value="F-actin_capping_bsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00231">
        <property type="entry name" value="F_ACTIN_CAPPING_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0503">Monooxygenase</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000438243" description="Cytochrome P450 monooxygenase cheE" evidence="2">
        <location>
            <begin position="1"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="499"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P04798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="23611317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="33622536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="33622536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000305" key="8">
        <source>
            <dbReference type="PubMed" id="23611317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9">
        <source>
            <dbReference type="PubMed" id="33622536"/>
        </source>
    </evidence>
    <sequence length="512" mass="57842" checksum="DE99E7E858527252" modified="2016-11-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GLX5</accession>
    <name>Q2GLX5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_11081</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408038">
        <property type="protein sequence ID" value="EAQ82905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230257.1">
        <property type="nucleotide sequence ID" value="XM_001230256.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2GLX5">
        <property type="interactions" value="435"/>
    </dbReference>
    <dbReference type="GeneID" id="4397396"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_11081"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001650_5_2_1"/>
    <dbReference type="InParanoid" id="Q2GLX5"/>
    <dbReference type="OMA" id="DWEDTIF"/>
    <dbReference type="OrthoDB" id="5151897at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="6">
        <location>
            <begin position="610"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="237"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ82905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1419" mass="157109" checksum="0F8843723374F3CA" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM37</accession>
    <name>Q2GM37_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_10967</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226234.1">
        <property type="nucleotide sequence ID" value="XM_001226233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GM37"/>
    <dbReference type="FunCoup" id="Q2GM37">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GM37"/>
    <dbReference type="GeneID" id="4397113"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10967"/>
    <dbReference type="eggNOG" id="KOG1946">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046065_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GM37"/>
    <dbReference type="OMA" id="KVWQYIR"/>
    <dbReference type="OrthoDB" id="10251073at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10567">
        <property type="entry name" value="SWIB-MDM2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="3">
        <location>
            <begin position="25"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="214"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ83149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="294" mass="32292" checksum="40197BC82DE786DA" modified="2006-03-21" version="1">MYVWPGVVRWARNLSSLPLTPAVTDEERATYTRVIDGVLALVDLETVTRKKIRQRLEEAVDKDLSSQKDAIKNLIEARFDAISGVVAQVPTPTSGTNDTNDTNDTNGHAPSEDEVRGAVIEVSLPPATKKQKRESSSEEADARLAAELQAQENRLSRGRVTRGAGTAKSGKPKAKPKAKPAKKKSAKRVRSDDDDSNADDSDASGKPKRKAGGGFQKPFNLSQPLADVCGESQLSRPQVVKKLWDYIKGNSLQDPSDKRQILCDDKLHAVFKQDKINMFSMNKLLGNQLYPVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM41</accession>
    <name>Q2GM41_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10963</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226230.1">
        <property type="nucleotide sequence ID" value="XM_001226229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GM41"/>
    <dbReference type="STRING" id="306901.Q2GM41"/>
    <dbReference type="GeneID" id="4397109"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10963"/>
    <dbReference type="eggNOG" id="KOG0700">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1239994_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GM41"/>
    <dbReference type="OMA" id="HMASSED"/>
    <dbReference type="OrthoDB" id="420076at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="223" mass="24304" checksum="A4D5D89172DB201E" modified="2006-03-21" version="1">MPKSCPASRRPARAPVPRSSSSTLQPRSHTSLAWETPVDVESGRLLNCAMTRSFGDNRWKWSLEALNRWQSAYFGRNCVSDYHSPPYITARPVVTSTETRLGDFVILASDGFRNHMASSEDAVHCAAMWIDAQSGQGGGEGEDAVTSQPSKPQPPAAPPSLVGEHQKEKPVDTGNRDGAHSPAGFLYNWTVQRDHFVVEEDNIATHLVNNAFGGTRRICSAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM49</accession>
    <name>Q2GM49_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226222.1">
        <property type="nucleotide sequence ID" value="XM_001226221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GM49"/>
    <dbReference type="GeneID" id="4397330"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10955"/>
    <dbReference type="eggNOG" id="ENOG502T5YJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1214619_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GM49"/>
    <dbReference type="OrthoDB" id="4584112at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="228" mass="25697" checksum="DDA8417FD040AA63" modified="2006-03-21" version="1">MPAPRMLLFDFFPRAGFIWRRWQGSPRILRSSSRDIVVQRALTVTSGGGVGLRRRDAQRLMVGAINLVAEKINGESGIRPDEGIIEYLERSADFSELSKATGPEVWTELIFQMADARSKYKRQTPQVRQDSDRNQLTTLALAIDGLLAAAGDRWDWLALELYAYPHLMGEAADYEIDEDSSEEEGDHDKKEKDPEGKDKAKDKGKGKGKGKEPPARKMEAARPVRRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM50</accession>
    <name>Q2GM50_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_10954</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226221.1">
        <property type="nucleotide sequence ID" value="XM_001226220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GM50"/>
    <dbReference type="STRING" id="306901.Q2GM50"/>
    <dbReference type="GeneID" id="4397329"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10954"/>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_125_13_1"/>
    <dbReference type="InParanoid" id="Q2GM50"/>
    <dbReference type="OMA" id="AWGAEHT"/>
    <dbReference type="OrthoDB" id="427518at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="569"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="737"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="904"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="264"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ83136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1002" mass="112952" checksum="6EE1FA12D1E9607E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMP3</accession>
    <name>Q2GMP3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ThuA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ82943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226028.1">
        <property type="nucleotide sequence ID" value="XM_001226027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMP3"/>
    <dbReference type="GeneID" id="4397253"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10761"/>
    <dbReference type="eggNOG" id="ENOG502RZ2Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057383_1_3_1"/>
    <dbReference type="InParanoid" id="Q2GMP3"/>
    <dbReference type="OMA" id="FTDEWYD"/>
    <dbReference type="OrthoDB" id="3482285at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40469:SF2">
        <property type="entry name" value="GALACTOSE-BINDING DOMAIN-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40469">
        <property type="entry name" value="SECRETED GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThuA-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ82943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="248" mass="27393" checksum="B5904CF6B4BCCAA5" modified="2006-03-21" version="1">MSSPFKMLIFSRTVLYRHESIPAGIQGLQRLAAASSTGENPFSADTTEDPSVFTPASLAAYRVIVLLQCSGNVLDDSQLDALKGFVRSGGGVVAIHCASYAMVSSEWYAGLIGGVFDNHPEPQLGRLKVENRDHPIMTCRCVQVHGDSRSADKSQEAQTELTWMDEWYNFKAHPRTTYNDLNVLLTVDEESYKGGVHGEDHPIAWCQTFDGGRSYYTSLGHFDEAYEDEWFMGQLLGGILWTAGVAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMS8</accession>
    <name>Q2GMS8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ82908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225993.1">
        <property type="nucleotide sequence ID" value="XM_001225992.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GMS8"/>
    <dbReference type="GeneID" id="4397325"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10726"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_245089_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GMS8"/>
    <dbReference type="OMA" id="EMQVMEI"/>
    <dbReference type="OrthoDB" id="427518at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040586">
        <property type="entry name" value="FxSxx_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ82908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1581" mass="176650" checksum="CEC414FB70BA19C6" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN59</accession>
    <name>Q2GN59_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228522.1">
        <property type="nucleotide sequence ID" value="XM_001228521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN59"/>
    <dbReference type="STRING" id="306901.Q2GN59"/>
    <dbReference type="GeneID" id="4397083"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10595"/>
    <dbReference type="eggNOG" id="ENOG502RFG7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_468507_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GN59"/>
    <dbReference type="OrthoDB" id="1922282at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018961">
        <property type="entry name" value="DnaJ_homolog_subfam-C_membr-28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39394:SF1">
        <property type="entry name" value="DNAJ HOMOLOGUE SUBFAMILY C MEMBER 28 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39394">
        <property type="entry name" value="YALI0E31793P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09350">
        <property type="entry name" value="DJC28_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="569"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="582" mass="62653" checksum="47B2893505AA7571" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN81</accession>
    <name>Q2GN81_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Jacalin-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228500.1">
        <property type="nucleotide sequence ID" value="XM_001228499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN81"/>
    <dbReference type="STRING" id="306901.Q2GN81"/>
    <dbReference type="GeneID" id="4396416"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10573"/>
    <dbReference type="eggNOG" id="ENOG502QPIS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032141_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GN81"/>
    <dbReference type="OMA" id="PHGTWFN"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09615">
        <property type="entry name" value="Jacalin_EEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF1">
        <property type="entry name" value="SPHINGOMYELINASE DDB_G0288017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00915">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208290" description="Jacalin-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Jacalin-type lectin" evidence="2">
        <location>
            <begin position="321"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="452" mass="48643" checksum="17551D0E9F15E3FD" modified="2006-03-21" version="1">MKVPQPVNAALAAALLLDTCLAATSGKFNILSMNVAGLPPIFNGNDVPGDKATNAANIGTKFAEYGHDVIHVQEDFNYHAHIYRTDTHPFRTATSGGVPFGSGLNTLSNFDWVDFRRVKWDTCSNASGADCLTPKGFTFMRAVVARPADNSTAVYVDFYNLHTDAGGEDDDLAARQHNVNQVAEYISKWSKGNAVVVHGDTNSRYSRVADTAIRSLLASENAGGPGMADPWIELQRGGVVPTEEVLCSNPASDNVCEVVDKVFYRSSPLVTLQAETFRYDSKRFLQDEGNVLSDHNPVFVDFAWSSGSSLRQSDFFGGAFGTWFSDVPALASITKPKPVTLAFRGGSRLDGVGLTLGDGTIFRHGGTSGTEVSLELGPSEYWVEGKLCRGEKSGKARNFYIQAATSLGRTLKAGTMTADCAIYSAPEGWQIVGFVGQDGDEIDQLAFVYAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNG0</accession>
    <name>Q2GNG0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pathway-specific nitrogen regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228421.1">
        <property type="nucleotide sequence ID" value="XM_001228420.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4396787"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10494"/>
    <dbReference type="eggNOG" id="ENOG502SAW3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_257324_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNG0"/>
    <dbReference type="OMA" id="QIDNHEK"/>
    <dbReference type="OrthoDB" id="5369448at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051647">
        <property type="entry name" value="Mediator_comp_sub12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007:SF8">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="758"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1161"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1261"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="891"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1161"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1290" mass="140781" checksum="B657B31E87F57455" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNI7</accession>
    <name>Q2GNI7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="3">4.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_10467</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:24404"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="4.1.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228394.1">
        <property type="nucleotide sequence ID" value="XM_001228393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNI7"/>
    <dbReference type="STRING" id="306901.Q2GNI7"/>
    <dbReference type="GeneID" id="4396176"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10467"/>
    <dbReference type="eggNOG" id="KOG2368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_458540_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNI7"/>
    <dbReference type="OrthoDB" id="1905920at2759"/>
    <dbReference type="UniPathway" id="UPA00896">
        <property type="reaction ID" value="UER00863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046951">
        <property type="term" value="P:ketone body biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07938">
        <property type="entry name" value="DRE_TIM_HMGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738:SF7">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="8">
        <location>
            <begin position="106"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="7">
        <location>
            <begin position="488"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ84063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="595" mass="66387" checksum="B2286FE7EA79D3E1" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPJ5</accession>
    <name>Q2GPJ5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228036.1">
        <property type="nucleotide sequence ID" value="XM_001228035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPJ5"/>
    <dbReference type="GeneID" id="4396572"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10109"/>
    <dbReference type="HOGENOM" id="CLU_980060_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPJ5"/>
    <dbReference type="OrthoDB" id="4583946at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="30650" checksum="D8E2E01D11E88C36" modified="2006-03-21" version="1">MPSLRLLRKFNAFARLRERAKAVKATDGYPARQADVGVNPAYKTAPAVVPNQRLHPQPPGAAVTIATGNTCPAPADKTIVVNAEDVAADGAVVGTSQRPRRGSSHAMPPAPPAAPASMLEALPAELRLQVLSHISDLCDLRALVFASPVFSQQYRLDRQHFLGRVLLRSLGSLTAEAYAVQGSSTIYSRSPGPLPAETVEQFIHSYVSRPFAPPELILQDCTLTDLAEMAAFYLSVAEPLLLQCAALFLQQLNPSLGVGSLSATEKTRLLRALYRFQFYCNIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPY7</accession>
    <name>Q2GPY7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_09967</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227894.1">
        <property type="nucleotide sequence ID" value="XM_001227893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPY7"/>
    <dbReference type="FunCoup" id="Q2GPY7">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="GeneID" id="4396108"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09967"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="InParanoid" id="Q2GPY7"/>
    <dbReference type="OMA" id="YVIPQFL"/>
    <dbReference type="OrthoDB" id="2351791at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000018">
        <property type="entry name" value="Putative MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF94">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="52"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="656"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="657"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ83563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="729" mass="78232" checksum="7E7205B773BE1AF4" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQ78</accession>
    <name>Q2GQ78_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450 55A2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_09876</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227803.1">
        <property type="nucleotide sequence ID" value="XM_001227802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQ78"/>
    <dbReference type="STRING" id="306901.Q2GQ78"/>
    <dbReference type="GeneID" id="4396019"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09876"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033716_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GQ78"/>
    <dbReference type="OMA" id="QEMISTC"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11030">
        <property type="entry name" value="CYP105-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000018">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46696">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46696:SF6">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ83472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="48329" checksum="375655C8DA69A2FC" modified="2006-03-21" version="1">MGTTAPNPATKDMPAFPFQRASGLEPPAEFARLRATDPVSQVRLYDGSAAWLVTKYRDVCRVATDRRLSKERSRPGFPEFSDGGKAAGKQRPTFVDMDPPEHMRHRSMVESWFTPEKVKSMEPYIDKTVNDLLDRMVAKGCTNGPVDLVEEFALPVPSYIIYTLLGVPFEDLEFLTQQNSIRTNGSATARDASAAADELIRYLTVLTNKRLEEPKNDIVSQLATNYVKTGKLEKADAVQMAFLLLVAGNATMVNMIALGVVTLFQHPEQLAELKADPAKWVGPFVEELCRYHTASAMAMKRTAKEDIEIGGQLIKAGQGIIASNQSANRDEEIFENPDTFNMHRKWPNEDPLGFGFGDHRCIAEHLAKAELRSAFTFLFKKAPGLKLAVPIKDIEYTPLQRDAFYVQEEQGSNTFRDVPPNFARTFLMSRTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQW6</accession>
    <name>Q2GQW6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_09638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227565.1">
        <property type="nucleotide sequence ID" value="XM_001227564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQW6"/>
    <dbReference type="FunCoup" id="Q2GQW6">
        <property type="interactions" value="396"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GQW6"/>
    <dbReference type="GeneID" id="4396120"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09638"/>
    <dbReference type="eggNOG" id="KOG1471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014001_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GQW6"/>
    <dbReference type="OMA" id="WAFSTVW"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120019">
        <property type="term" value="F:phosphatidylcholine transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032120">
        <property type="term" value="P:ascospore-type prospore membrane formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031322">
        <property type="term" value="P:ascospore-type prospore-specific spindle pole body remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120010">
        <property type="term" value="P:intermembrane phospholipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="107"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="344" mass="38652" checksum="0C4AEFDFF7F53A95" modified="2006-03-21" version="1">MAAPAPAPSTLELDPKYDNYDFPTTPPKPQNGHPGYLTAQQQAQVHQLRLLLESEGYTERLDTLTLLRFLRARKFDVELTKKMFVECEKWRKETKLDEELPNWDYPEKKEVFKYYPQYYHKTDKDGRPVYIEQLGSIDLTAMYKITTESRMLTNLAVEYERVSDPRLPACSRKAGVLLETCCTIMDFKGVGLSKASQVFNYVKQASGLSQNYYPERLGHLYLINTPWGFSTVWSVVKGWLDPVTVEKIHVLGSGYKSELLKQIPAENLPQQFGGTCQCEGGCELSDMGPWREAEWAKPAKWEKKAEKADTTAQTAPPAVAEGTQLPIAETADADKAGAAAPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GR61</accession>
    <name>Q2GR61_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_09543</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227470.1">
        <property type="nucleotide sequence ID" value="XM_001227469.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GR61"/>
    <dbReference type="GeneID" id="4395185"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09543"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000092_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GR61"/>
    <dbReference type="OMA" id="HHIVTEG"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031169">
        <property type="term" value="P:ferrichrome biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.980:FF:000001">
        <property type="entry name" value="Non-ribosomal peptide synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000033">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000024">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="534"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1600"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="2154"/>
            <end position="2227"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="3235"/>
            <end position="3312"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="3794"/>
            <end position="3870"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="4360"/>
            <end position="4433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ85529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="4915" mass="540080" checksum="87E1D7C23607BBC5" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRH3</accession>
    <name>Q2GRH3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GPI transamidase component GPI16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_09431</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227358.1">
        <property type="nucleotide sequence ID" value="XM_001227357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRH3"/>
    <dbReference type="FunCoup" id="Q2GRH3">
        <property type="interactions" value="489"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GRH3"/>
    <dbReference type="GeneID" id="4395060"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09431"/>
    <dbReference type="eggNOG" id="KOG2407">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021459_2_1_1"/>
    <dbReference type="InParanoid" id="Q2GRH3"/>
    <dbReference type="OMA" id="NHGHYIG"/>
    <dbReference type="OrthoDB" id="331263at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007245">
        <property type="entry name" value="PIG-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959:SF11">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04113">
        <property type="entry name" value="Gpi16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208532" description="GPI transamidase component GPI16" evidence="3">
        <location>
            <begin position="25"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="535"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ85417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="590" mass="65703" checksum="480212E78B6E515D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRR2</accession>
    <name>Q2GRR2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_09342</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227269.1">
        <property type="nucleotide sequence ID" value="XM_001227268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRR2"/>
    <dbReference type="GeneID" id="4395106"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09342"/>
    <dbReference type="eggNOG" id="ENOG502SJFM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_3_0_1"/>
    <dbReference type="InParanoid" id="Q2GRR2"/>
    <dbReference type="OMA" id="AIFPWII"/>
    <dbReference type="OrthoDB" id="3923077at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF93">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="31"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="283"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ85328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="443" mass="48192" checksum="8B7959FE2A7860C0" modified="2006-03-21" version="1">MVAPVGIKGDGPWSLAVMWLLASLVFFFLILRFYTRVVCLASYGLDDHVYLVAFIFLLIFTIFTTLAGNYGFGQTMEEIGSMDAVVQATLYECIGQGFAIVGMAIAKASLGFFLLRLVTITWHRIAIWSAMTLVMLASIAQVLCFWLSCVPLDFVYDRRIPGGYCPIDTRPTSYILCISTILVDFFFAIFPWIIVWPLKMPQREKYTIAGSMSLGLIAAAAGIKRTTEVEGLYTPNYLKDSVGLIVWSAAEMSITLICIGIPVCRPLYKRAFRRLFGETSSAGYQKQSGDGGGGGDNQSNSVPLRTIGGGLVGADGKPIAGSKKHHPSANNSRNKSGLDDTCVDKTTNGSTDDVSFSDVKLGVGGPFTRTTVGRGRRESGDNASEEEILGDEFRRSQIQTGRRSDEERNTSSGGSSGRGHPNTHGQVGHNGIMVTETYRVERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRU5</accession>
    <name>Q2GRU5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_09309</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227236.1">
        <property type="nucleotide sequence ID" value="XM_001227235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRU5"/>
    <dbReference type="STRING" id="306901.Q2GRU5"/>
    <dbReference type="GeneID" id="4394850"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09309"/>
    <dbReference type="eggNOG" id="KOG3752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_368804_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRU5"/>
    <dbReference type="OrthoDB" id="407198at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13934">
        <property type="entry name" value="RNase_H_Dikarya_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="9">
        <location>
            <begin position="579"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="502"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="507"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ85295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="755" mass="84308" checksum="9B46B1115FD39CC5" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GS11</accession>
    <name>Q2GS11_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Intradiol ring-cleavage dioxygenases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_09243</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227170.1">
        <property type="nucleotide sequence ID" value="XM_001227169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GS11"/>
    <dbReference type="STRING" id="306901.Q2GS11"/>
    <dbReference type="GeneID" id="4395778"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09243"/>
    <dbReference type="eggNOG" id="ENOG502SMA8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_808936_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GS11"/>
    <dbReference type="OrthoDB" id="5238185at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF5">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASE PRCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="4">
        <location>
            <begin position="72"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ85229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="343" mass="38381" checksum="CD6C5B8DC672C3B7" modified="2006-03-21" version="1">MTLPARQSSPLTSGWRVSSSSTPWARFMSRASKTRNETHRICDVLGLESLVDEIAHKIVSESGMDPTSSSILGPFWSPNAPFRAHGDVIFQDGVPAGGRVTKMHGVIRDITTGQPIPNAVFDIWQASSNGKYDFQDPDNQSPNNLRGKFRADANGRYWFYCLHPTAYSLPRDGPSWQLLTMMDRHPMRPAHIHIMVTHQDFQGCTTQLYPSDDPWIKSDTVFAVKDDLVVEFKPLKDDPKATLGARVQCQPRAQGLQGPPLGDEGVTARGVTMGKVKGCVSLLYIYRPMYIPYFGHGLDAVGKGFVIQRTSDHIIWTCMRIDERASTHLRCHMSRLCYAFLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSR7</accession>
    <name>Q2GSR7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226914.1">
        <property type="nucleotide sequence ID" value="XM_001226913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSR7"/>
    <dbReference type="GeneID" id="4395254"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08987"/>
    <dbReference type="eggNOG" id="ENOG502S7GF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038380_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GSR7"/>
    <dbReference type="OMA" id="SWEPYSP"/>
    <dbReference type="OrthoDB" id="5398515at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="449" mass="48816" checksum="332CBC28A515D60E" modified="2006-03-21" version="1">MADTMKPIVPSTPSPGPTSRIRTPTAPQHGYSDSYEPYSPRKSSRIAQRATNRTPSPQPPRHRASHQTEGTTASPKSTKKRFISTMATPAISPQKKRLPPLDSSRRASGTLTAEATAHAAVALGLSPAPTPARKPESLSTRRGAAASAGMLMTPAKTPQRPPNEKVKAKVKSVARNLFHSDEEEAMPSPRKVRTQTDNPDSFYSGDAAETSFQIFTDSHERIPEVDNSVDNPFYVGPNPVAPEAPRRRSKRNTVSIPGEGKVPIDEAIRREDGMLIVFRGKKQFRKFTEMDEPSNRDGLDEGEGGLESAVESPTKRHFTRSSIKPRLLFPTADSDESKELDEDEEAATDIEDHVLAGLEADKPETPADMIDKTPGTPEAPRYAPASPPTTVRTTRFSNKKSAEPTPKPKKAAKRSPFDSWPRVKGGSHSAGQKRSGDDLSAAAPKRTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTM1</accession>
    <name>Q2GTM1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_08683</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226610.1">
        <property type="nucleotide sequence ID" value="XM_001226609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTM1"/>
    <dbReference type="GeneID" id="4395153"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08683"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_5_0_1"/>
    <dbReference type="InParanoid" id="Q2GTM1"/>
    <dbReference type="OMA" id="RRWWYEL"/>
    <dbReference type="OrthoDB" id="10006946at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
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        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
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        <location>
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            <end position="377"/>
        </location>
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        <location>
            <begin position="455"/>
            <end position="521"/>
        </location>
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        <location>
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            <end position="465"/>
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        <location>
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            <end position="484"/>
        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="EAQ84669.1"/>
        </source>
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        </source>
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    <sequence length="611" mass="66875" checksum="F46B67A644CBE0CE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTV6</accession>
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        </submittedName>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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        </lineage>
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    <reference evidence="3" key="1">
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="368"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="EAQ84584.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="577" mass="64201" checksum="E192C29AFAF3D7BB" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTX9</accession>
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        <lineage>
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                <person name="Untereiner W.A."/>
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            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0862">Zinc</keyword>
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        <location>
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        <location>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ84561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="992" mass="111450" checksum="2CB72EC464BCD6D5" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU09</accession>
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        <recommendedName>
            <fullName evidence="6">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">CHGG_08545</name>
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    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226472.1">
        <property type="nucleotide sequence ID" value="XM_001226471.1"/>
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    <dbReference type="GeneID" id="4395432"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08545"/>
    <dbReference type="eggNOG" id="ENOG502RZYU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073360_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GU09"/>
    <dbReference type="OMA" id="WGNGACR"/>
    <dbReference type="OrthoDB" id="2141514at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208606" description="CBM1 domain-containing protein" evidence="5">
        <location>
            <begin position="17"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="6">
        <location>
            <begin position="300"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ84531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="336" mass="34627" checksum="09F228585F87029E" modified="2006-03-21" version="1">MKVLLPGLILAGQLSASPVALEERQASTGNGPFAPAGYYTSNAFGGHTFYAPKTIPSNAKLPVLLWGNGGCSADATGQAPFLTQLASYGVLVIASGTPGGGGSTTADMMKQSIDFITRNAGSGAWANIDASRITAAGWSCGGVEAYAQIWDPRVQSVGIWNSGLLTNYTSARDFRKPVFFFLGGPSDIAYQNGERDYNAMQSGVPKWKGNLNVGHGGTYTDYNGGKYGIIGANWVKWILRGDTSASGYLTGSGARNDGWSVVSADLDKINVTPIGEGTGGGGSPTTTASTPEPTGGNGGVCSPLWGQCGGDGWAGPKCCSQGSCKASNQWYSQCLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU97</accession>
    <name>Q2GU97_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226384.1">
        <property type="nucleotide sequence ID" value="XM_001226383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GU97"/>
    <dbReference type="GeneID" id="4395379"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08457"/>
    <dbReference type="eggNOG" id="KOG1269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057148_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GU97"/>
    <dbReference type="OMA" id="LSFGTWC"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="24349" checksum="546BA5A6F858C150" modified="2006-03-21" version="1">MSIPPPPQPAPASAPDPEQPYAPGHAASQTQHHEWRTASNSAAHLLSHLRRLAPTQHHPLHLLDVGAGSGTISASLVQHLAPLGGSVVATDISDEILARAADHAADRRRGLRKFHKLMVATLVANGGEDRGGRKLLSWVLEAGVDSEDVEAGFGAWCFSTAEDKRVWGESMISRLQTGQMRDKGLEMGITTVQDIEDMIKAWREWIRTEGATLGLMNGEVIVKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUD0</accession>
    <name>Q2GUD0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_08424</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226351.1">
        <property type="nucleotide sequence ID" value="XM_001226350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUD0"/>
    <dbReference type="STRING" id="306901.Q2GUD0"/>
    <dbReference type="GeneID" id="4394672"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08424"/>
    <dbReference type="eggNOG" id="KOG4336">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026584_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GUD0"/>
    <dbReference type="OMA" id="HDWIYAL"/>
    <dbReference type="OrthoDB" id="2193813at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019473">
        <property type="entry name" value="TFIID_su8_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10406">
        <property type="entry name" value="TAF8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="8">
        <location>
            <begin position="62"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor TFIID subunit 8 C-terminal" evidence="9">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="218"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ84410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="372" mass="40633" checksum="7542E914BBEBCFAC" modified="2006-03-21" version="1">MLSAAVEEEYTTMSIESRKRPTATDHDSSDAKRQRVQSPHVILSVGKIGASSCSSATTTTDEVANKGLRRAVALALDKVGFEGAAPEAMESFTVMVETYITSLSESVRMYQNAARRAHPIPGDFELALGRFNLTTSLLDPHRKPPIPRSKRLPVLEPLPIIDRLEKDLPILGRELDGAPDKAVKQYIPGSFPAFPSIHTYKCTPESVDAVTVSDDWGVFSPDAPSQSLDGSQSQPQQPQRPLAPDEIPRGDPKKMREAAAKEAKAGEGALRRLMRASKIAKQKEVWSAAQRQPARRDRYNLWEAAMRELIEDDTKSKGKEIVPAAMHGDKGRFEIADHSMIVNTEQACLRQDIPRAGVRKAAAAGHGISGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUJ6</accession>
    <name>Q2GUJ6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Short-chain dehydrogenase/reductase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_08358</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226285.1">
        <property type="nucleotide sequence ID" value="XM_001226284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUJ6"/>
    <dbReference type="GeneID" id="4394754"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08358"/>
    <dbReference type="eggNOG" id="KOG1201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_5_2_1"/>
    <dbReference type="InParanoid" id="Q2GUJ6"/>
    <dbReference type="OMA" id="CDITTVE"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000131">
        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ84344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="273" mass="29499" checksum="35552684BA67BAA0" modified="2006-03-21" version="1">MASNSWRLTAAKGWDWPNEIAVVTGGSSGIGKGIVERLVALGVRVAVLDIQELPKELQGNPRIRFFHCDVTSAESVAAAADAVRSEFGHPSILVNNAGIARPMPILKTPEEYLRKIFGVNVMSLWFTTQQFLPRMIQLNKGHIVTVASIASFVALATAADYSATKAGALAFHESLASEIKHQYKAPSVLTSVIHPNFVRTPLVDGFAGRLERSGVRMLTSDRIADEVIAQIKSRRGGQLVIPNSATGISAIRGWPTWLQEVIRDAVARGAVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUN8</accession>
    <name>Q2GUN8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_08316</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ87063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225972.1">
        <property type="nucleotide sequence ID" value="XM_001225971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUN8"/>
    <dbReference type="STRING" id="306901.Q2GUN8"/>
    <dbReference type="GeneID" id="4394138"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08316"/>
    <dbReference type="eggNOG" id="ENOG502RS6M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_874363_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUN8"/>
    <dbReference type="OrthoDB" id="4759647at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22150">
        <property type="entry name" value="F-box_CeFBXA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="117"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ87063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="318" mass="35241" checksum="53C16CE82F7C4DD5" modified="2006-03-21" version="1">MASLIPFTPVTVDPMLPTNPVSNTSTSGPSPSCPVSPEPAAQGGSFIHELIGLSPTGFRETVRNSFSSLARREDHDYTTASSPQPGADVVTNLKSGNPHTTHTRLPLPPPPPPEPCPRHLLTLPPEIWLLILQRLAFADMVRLRKTCKRLRALIDPKQIRTLYGPAQLYTQLLSHCKACLLYDPFRSHLLRSVRTDPGYPLASCCLSCAIKARDPRIRVGKKLDLANFDTVWVCRWCGFPITDGGAFGCEQMHRFCYKRYNDVLFAFFSAGWIQLGLGIVAAALAWRYYRYAILVFAPTVVLSLALATRGKRIIGSWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUS8</accession>
    <name>Q2GUS8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_08276</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ87023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225932.1">
        <property type="nucleotide sequence ID" value="XM_001225931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUS8"/>
    <dbReference type="STRING" id="306901.Q2GUS8"/>
    <dbReference type="GeneID" id="4394508"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08276"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011025_2_1_1"/>
    <dbReference type="InParanoid" id="Q2GUS8"/>
    <dbReference type="OMA" id="GPIFWEI"/>
    <dbReference type="OrthoDB" id="413885at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.10">
        <property type="entry name" value="Cholesterol Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053208">
        <property type="entry name" value="GMC_Oxidoreductase_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190:SF2">
        <property type="entry name" value="CELLOBIOSE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G17620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208212" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ87023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="523" mass="56210" checksum="F37D57B0EC41FA5C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUX8</accession>
    <name>Q2GUX8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225882.1">
        <property type="nucleotide sequence ID" value="XM_001225881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUX8"/>
    <dbReference type="GeneID" id="4393814"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08226"/>
    <dbReference type="HOGENOM" id="CLU_2722009_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUX8"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="72" mass="7582" checksum="CEDEB23F7273A02B" modified="2006-03-21" version="1">MENGTHGPVIGSPGARPFSRQCLGGETSPRTQRREPDAACGVTPGKTDAISPGYRGQKDSVKRDTNFVPQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUZ4</accession>
    <name>Q2GUZ4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ceramide very long chain fatty acid hydroxylase</fullName>
            <ecNumber evidence="18">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CHGG_08210</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="18"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225866.1">
        <property type="nucleotide sequence ID" value="XM_001225865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUZ4"/>
    <dbReference type="FunCoup" id="Q2GUZ4">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GUZ4"/>
    <dbReference type="GeneID" id="4394564"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08210"/>
    <dbReference type="eggNOG" id="KOG0539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034756_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GUZ4"/>
    <dbReference type="OMA" id="WTIIEYV"/>
    <dbReference type="OrthoDB" id="2204368at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005149">
        <property type="entry name" value="IPC-B_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17 18" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 20" id="KW-0349">Heme</keyword>
    <keyword evidence="14 18 20" id="KW-0408">Iron</keyword>
    <keyword evidence="5 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 19" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="22">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR005149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EAQ86957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="379" mass="42895" checksum="9F4A1BDC0D6BA64C" modified="2006-03-21" version="1">MPGRTLPTFTLAEVEAHNSAKSCYVTLGKNVYDVTDFIDAHPGGGELVLEYAGKDIKDILEDEASHEHSQAAYEVLEDSHIGFLAPANGSANGKAEVGNGNGMANGESNGANGTYVHPRTGMSCEEDLSKDTDISSDYKTHKFLDLSRPLFPQVWFGGFSKDFYLDQVHRPRHYKGGESAPLFGNFLEPLTKTAWWVVPTLWLPCVSYGLYIASPGFTSPLGEAGCFAFGLFAWTLIEYIMHRFLFHLDDYLPDNRVGITLHFTLHGIHHYLPMDKYRLVMPPTLFVALALPFWKVAHGIFFWDWYMGTAAYCGGVFGYICYDMTHYFLHHQNLPLWWKQLKKYHLEHHFLDYENGFGVTSPLWDKVFGTELVTKPKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVD7</accession>
    <name>Q2GVD7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_08067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225723.1">
        <property type="nucleotide sequence ID" value="XM_001225722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVD7"/>
    <dbReference type="GeneID" id="4394530"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08067"/>
    <dbReference type="HOGENOM" id="CLU_2512425_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GVD7"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ86814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="85" mass="9536" checksum="653800C9F2C98F6B" modified="2006-03-21" version="1">MIEVGVQRYHGAEVDYRGPRRGSRCAPAGRSRLHDICAALGRKDSWMDVRAMLAFLDLTQSPRVWDAENACRPLVDDNTPALQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVE6</accession>
    <name>Q2GVE6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-activating enzyme E1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_08058</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225714.1">
        <property type="nucleotide sequence ID" value="XM_001225713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVE6"/>
    <dbReference type="FunCoup" id="Q2GVE6">
        <property type="interactions" value="1538"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GVE6"/>
    <dbReference type="GeneID" id="4394616"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08058"/>
    <dbReference type="eggNOG" id="KOG2013">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_7_3_1"/>
    <dbReference type="InParanoid" id="Q2GVE6"/>
    <dbReference type="OMA" id="SKEISWE"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
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    </dbReference>
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        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF5">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
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        <location>
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            <end position="407"/>
        </location>
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        <location>
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            <end position="516"/>
        </location>
    </feature>
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        <location>
            <position position="174"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00073512"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ86805.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="553" mass="60903" checksum="037F9A5F6FB9CCE4" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVX1</accession>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
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                <person name="Grabherr M."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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            <end position="314"/>
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        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ86630.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="792" mass="87713" checksum="12BB45BD5A71D44A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWH4</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="common">Soil fungus</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
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            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="265" mass="29123" checksum="17F6D8F6D032D4B6" modified="2006-03-21" version="1">MPTKGHQRSRSSIDRVIDLLADLEDNQISLLLDDLNHTTSSNVAVPDAIALFEHHANKPRNRSCRSPSPLRTLQVELERRHSKRLSAAPERLSRFKAANPQPPAPQDLATPSPSPSPPPTEDLFDQPNFNDSFSLDLSPPPVSFDHPKTSSAGPPPVFRPRSYKRISRPMFLSPTATAELHLLLLAFFNETPLPPVSPVTTATPSPTTPLFGFSHSPFTDFEVEPNTPGLDLLEPSPTRTPSFSGGRSLKTMPSISSIFEVMRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXI4</accession>
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        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
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        <name evidence="4" type="ORF">CHGG_07320</name>
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    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    <dbReference type="GeneID" id="4394074"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07320"/>
    <dbReference type="eggNOG" id="ENOG502R6NR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018979_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GXI4"/>
    <dbReference type="OMA" id="CPLVGSM"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
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        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="272"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="602"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ86067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="649" mass="71890" checksum="C18B0483FD1398CC" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYI8</accession>
    <name>Q2GYI8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224622.1">
        <property type="nucleotide sequence ID" value="XM_001224621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYI8"/>
    <dbReference type="GeneID" id="4394018"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06966"/>
    <dbReference type="eggNOG" id="ENOG502TB0F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1073633_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYI8"/>
    <dbReference type="OMA" id="RIRENRH"/>
    <dbReference type="OrthoDB" id="10494626at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="259" mass="27227" checksum="F1B5474EF33112E5" modified="2006-03-21" version="1">MINVGYNLCLPAKYGRDIQTVGLDTCIGVVAYGLPSTQGGVNKVMAHASTGGVDEIIGQRFIAEVQKSRMTIHGICMSCPSPDRNNNGPDKLSDDDIRRTLAEEYGLHPSQVTPARIQQFRDGLVRMLQGANNRAAEYCVQYFGVNPTVRIRENRHVRDPPPYGTLVASASPGGEVRAEGHRMASIPNGTATAAPAAAAASSSRDSAPKRAPAAPSSSSKKPASASNSKKPPPVSSSAKKPPPASSSSSRHKSSSSRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYQ8</accession>
    <name>Q2GYQ8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_06896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224552.1">
        <property type="nucleotide sequence ID" value="XM_001224551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYQ8"/>
    <dbReference type="GeneID" id="4393134"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06896"/>
    <dbReference type="eggNOG" id="ENOG502QVV4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_818900_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYQ8"/>
    <dbReference type="OrthoDB" id="3142841at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF5">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01222)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ85643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="339" mass="37214" checksum="A0516008DC50EF73" modified="2006-03-21" version="1">MTSVSRHLSLPGPPVRPPRPTSPSHTIPPRGVRPMRPAPIYNQQRPSNPRLEASLPPPPAPLGDDVSDCESDSSDDESDTQPLRNSFLGVRTSIVRAPRDVEEAGASVNSSSNTLSGTPPLSAKEFKPKAVVSEPDLFESHGLDTSPLPPKKGSRFYRYLRWNFGSVYRRIFCLVYLSKLTYQQASIAVTANILAAMLVRNEHVVNSMFWVFGTWTKNLPFRIRTLAAKVYSYGGIHSGGAVAATCWYIAFLVLLTMEFQSAGSLSVLRSYIYFGYSATFILFLLVSNAGPSAANPHLRRHHAQLVRGYPPLHGPWLASFCCFWGPKVMAGSPPSPSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYW1</accession>
    <name>Q2GYW1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_06843</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224499.1">
        <property type="nucleotide sequence ID" value="XM_001224498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYW1"/>
    <dbReference type="FunCoup" id="Q2GYW1">
        <property type="interactions" value="664"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GYW1"/>
    <dbReference type="GeneID" id="4394376"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06843"/>
    <dbReference type="eggNOG" id="KOG0569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_357878_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYW1"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="588"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="618"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="678"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="718"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="749"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="300"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="551"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ85590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="783" mass="83850" checksum="684BFF402B4F4C83" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZ69</accession>
    <name>Q2GZ69_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thiamine pyrophosphokinase</fullName>
            <ecNumber evidence="7">2.7.6.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_05177</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>thiamine + ATP = thiamine diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11576"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the thiamine pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.2" evidence="7"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224391.1">
        <property type="nucleotide sequence ID" value="XM_001224390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZ69"/>
    <dbReference type="FunCoup" id="Q2GZ69">
        <property type="interactions" value="258"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GZ69"/>
    <dbReference type="GeneID" id="4392539"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05177"/>
    <dbReference type="eggNOG" id="KOG3153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044237_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZ69"/>
    <dbReference type="OMA" id="HHLYMMT"/>
    <dbReference type="OrthoDB" id="25149at2759"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016966">
        <property type="entry name" value="Thiamin_pyrophosphokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031057">
        <property type="entry name" value="Thiamin_pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="Thiamin pyrophosphokinase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase thiamin-binding" evidence="8">
        <location>
            <begin position="214"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ88558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="306" mass="33559" checksum="12BB33BB2301F35C" modified="2006-03-21" version="1">MIEHHDDAIANQRSRSFEWNPADLIQARSQIDDKTTSDQFALIVLNQPLHYLDVTRRLWENAQVRIAADGGANALYEAAGQHGDSCFDDLAMIIGDLDSLTPAVHSYYASQKTSGPQTLVIRDPDQESTDFGKAVAYIRQHYHTTTSIPNSHPHHHHATPKPLDIVAIGGLGGRVDQGLSQLHHLYLFQTDAHYADGRMYLFSGESLTFLLKAGRHRIRVREEGSVVSGGGGGGNGGGDVFGKHVGILPVGAASRITTRGLEWDVQDWETRFGGRVSTSNHVLPTTEVVEVETTEEVLFTIALRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZI6</accession>
    <name>Q2GZI6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224274.1">
        <property type="nucleotide sequence ID" value="XM_001224273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZI6"/>
    <dbReference type="GeneID" id="4392641"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05060"/>
    <dbReference type="HOGENOM" id="CLU_044732_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZI6"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="351" mass="38141" checksum="7C585B43846A98C1" modified="2006-03-21" version="1">MLDPFCPVTGKRHPVPGSAKFTEVCKRCKTTLLLDLVSDDDSDHGISANSALTPVSPVAIPPAQPSQSVQPTQSTPDITTTPRPSQAGQALTGFNKAHSTALAERNSPNPNVKPVQPSPVVISITLEVFAADVDVVTIGGQETRRWTEVGSISSCLPVQVPLDQHFANHEHIIRYLLDNACRAKKFAPSEFRFIGKLSAGKNKKVSEMTSLDPERPVTFRDLHKATTNRGNVKPDENVSLYLLKEKLYPVVREEREDLAVKKTAKRARSDTQGLTAIASSSKLVGGLSVLSKKAKKTAGRYNLETGALGKNVSDKLIGTIKDDLTGRSLMRKTWRNVAEYNLIPVVACEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZU9</accession>
    <name>Q2GZU9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224161.1">
        <property type="nucleotide sequence ID" value="XM_001224160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZU9"/>
    <dbReference type="GeneID" id="4392135"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04947"/>
    <dbReference type="eggNOG" id="ENOG502S5RV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047275_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZU9"/>
    <dbReference type="OMA" id="WKWWEIA"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="122"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="495" mass="54809" checksum="03F77295A5BF548B" modified="2006-03-21" version="1">MGRIPRQEATIVFNTSPLHSTSSSNATFLAAEDSDNGFKLEYAGSNTDITDVATCTDTDTDSEPDSDSDGSYIDISSNAERPEDWTTKTYSTLKSLVAAAKGGVSKPVVQFIKKHLKGTKLIFVVGQTGTGKSSLLKELTGQDINIGKSHKSGTEEYEVCPAVIDGEQYLFVDTAGFGAGDRKDFDNFFDVVTCLDALAPFVTIAGLIFVYGGTQERMYAHDLTTTQWVKCFCGPEFYQYITIVTTKWDMLQQEAFTEAWERFDGVVKDPVVADILSPAPAGTKRYHPGSVYHHGVVMDDANLGTPLRCLPKTTCANERTKRARAMIMNRYSTRPEVKPQILRQMAAGVLWYETEAAKLLRNSHLAIKLTIVDHFLRVTVIPDKKPAELTTKPKSRRTASTLPPAPAFLALPPPDPTPVTEKPAKPSAKPKVRKTTSTLPSVPLVLTLPPAARSEDPWTEKPKRSWYSRIWDWLEKAKELAFFFRRQKRAASNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H005</accession>
    <name>Q2H005_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_04891</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224105.1">
        <property type="nucleotide sequence ID" value="XM_001224104.1"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H109</accession>
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                <person name="Untereiner W.A."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <end position="589"/>
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        <location>
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        <location>
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    <sequence length="896" mass="98584" checksum="8E56F6422449EBB4" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H177</accession>
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the AAA ATPase family.</text>
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    <dbReference type="GeneID" id="4392355"/>
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    <dbReference type="eggNOG" id="KOG0652">
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    <dbReference type="OMA" id="ANACVGF"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="45"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ87850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="210" mass="23278" checksum="9FEF988A3B024E4A" modified="2006-03-21" version="1">MEVDEKPTEKYTDVGGLTKQIDELLEAIVWPMKEADRFKKIGIKAPKGALMYGPPGTGKTLLARACAAQTDATFLKLAGPQLVQMFIGDGAKLVRDCFALAKEKAPAIIFIDELDAVGTKRFDSEKSGDREVQRTMLELLNQLDGFASDDRIKVIAATNRVDVLDPALLRSGRLDRKIEFPLPNEEARAQILKIHSRKMKVDEATVNFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H195</accession>
    <name>Q2H195_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose 5-phosphate isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223665.1">
        <property type="nucleotide sequence ID" value="XM_001223664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H195"/>
    <dbReference type="STRING" id="306901.Q2H195"/>
    <dbReference type="GeneID" id="4391646"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04451"/>
    <dbReference type="eggNOG" id="ENOG502RZN7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091396_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H195"/>
    <dbReference type="OMA" id="YPPFCLR"/>
    <dbReference type="OrthoDB" id="2106730at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1400.10:FF:000004">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="entry name" value="Sugar-phosphate isomerase, RpiB/LacA/LacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051812">
        <property type="entry name" value="SPI_LacAB/RpiB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004051">
        <property type="entry name" value="PRK05571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732:SF1">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="Ribose/Galactose isomerase RpiB/AlsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="17320" checksum="872BD26FFBB65A70" modified="2006-03-21" version="1">MSSPKWRIVVGCDDAGVGYKNKIKADFAADDRVASVIDVGADDKTAYPHVAAKAAKLVASGECDRALLICGTGLGVAISANKIKGIRAVTAHDSFSVERAVLSNNAQVLCMGERVVGLELARRLAKEWLGYVFDESSPSAAKVAAIHEYEEGEGGLSGHEEVKGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1Y3</accession>
    <name>Q2H1Y3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_04213</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223427.1">
        <property type="nucleotide sequence ID" value="XM_001223426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1Y3"/>
    <dbReference type="STRING" id="306901.Q2H1Y3"/>
    <dbReference type="GeneID" id="4392237"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04213"/>
    <dbReference type="eggNOG" id="ENOG502SJ0B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104262_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H1Y3"/>
    <dbReference type="OrthoDB" id="3561681at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ87594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="232" mass="25997" checksum="73F2FFBBF47599D8" modified="2006-03-21" version="1">MYRLSPTPSCSRAPGGGVRICRVDLPFIWMGVWVGEAYSVDLWIEVWQLRMVLLAWGEEVRKMEGEVGAVGVVGAVASCGGTETGARIRKRLGEIRAEYEGFVRECSMVIEGMALSAQLSWSQIGYQDTQANLKIASDTREDSNQMRSIAFLTMVFLPATFLAAVFSMTFFNWKPEEGERFVSPYIGIYIGLAVVVTAVVLSCWIWFTRRNRVSYSDDDEKPLLEDYPTGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H202</accession>
    <name>Q2H202_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_04194</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223408.1">
        <property type="nucleotide sequence ID" value="XM_001223407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H202"/>
    <dbReference type="GeneID" id="4392968"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04194"/>
    <dbReference type="eggNOG" id="ENOG502SIJF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014597_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H202"/>
    <dbReference type="OMA" id="PPAYHHA"/>
    <dbReference type="OrthoDB" id="406634at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF11">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ87575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="651" mass="71155" checksum="809CAABD505E68AC" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2M3</accession>
    <name>Q2H2M3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_03973</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223187.1">
        <property type="nucleotide sequence ID" value="XM_001223186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2M3"/>
    <dbReference type="STRING" id="306901.Q2H2M3"/>
    <dbReference type="GeneID" id="4392062"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03973"/>
    <dbReference type="eggNOG" id="ENOG502QURB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005024_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H2M3"/>
    <dbReference type="OMA" id="DLFQSHF"/>
    <dbReference type="OrthoDB" id="5370478at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="48"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="800"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="800"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="830"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="869"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="886"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ87354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="992" mass="109074" checksum="67E9742491ABC180" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2U3</accession>
    <name>Q2H2U3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223117.1">
        <property type="nucleotide sequence ID" value="XM_001223116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2U3"/>
    <dbReference type="GeneID" id="4392393"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03903"/>
    <dbReference type="HOGENOM" id="CLU_1261369_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2U3"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="219" mass="24058" checksum="319D1F06A215411F" modified="2006-03-21" version="1">MSIICHSTLIEHKHIASLSCVHLEPIVHRRVNSSSPQNNRDLPRARTAGGCFRTRQQWNVDRAVLVPSEHPSITRTHVPAQGDNNPGSKDALSHPRPDPGMPPHPVPHSECPPSRSSSVIPTLITKRRMMYSHPEHGHQGIRSSSLVSTQPPFSARTCICPALPCPTPFPLPPLKPTTGARSLTPRAKQTRTPSRDVEMEMEMETGTTLEIRGPSTSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H359</accession>
    <name>Q2H359_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">xylan 1,4-beta-xylosidase</fullName>
            <ecNumber evidence="11">3.2.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_03787</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Hydrolysis of (1-&gt;4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini.</text>
            <dbReference type="EC" id="3.2.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="11"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223001.1">
        <property type="nucleotide sequence ID" value="XM_001223000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H359"/>
    <dbReference type="STRING" id="306901.Q2H359"/>
    <dbReference type="GeneID" id="4391523"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03787"/>
    <dbReference type="eggNOG" id="ENOG502SHDC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_5_3_1"/>
    <dbReference type="InParanoid" id="Q2H359"/>
    <dbReference type="OMA" id="LETHTEN"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF3">
        <property type="entry name" value="BETA-D-XYLOSIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="12">
        <location>
            <begin position="105"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 3 C-terminal" evidence="13">
        <location>
            <begin position="359"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ87168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="572" mass="62244" checksum="4FF7C417FB15AB1C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3A6</accession>
    <name>Q2H3A6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_03740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the esterase D family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222954.1">
        <property type="nucleotide sequence ID" value="XM_001222953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3A6"/>
    <dbReference type="GeneID" id="4392758"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03740"/>
    <dbReference type="eggNOG" id="ENOG502S92V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039834_3_0_1"/>
    <dbReference type="InParanoid" id="Q2H3A6"/>
    <dbReference type="OMA" id="VPNTLEW"/>
    <dbReference type="OrthoDB" id="446683at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052558">
        <property type="entry name" value="Siderophore_Hydrolase_D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40841">
        <property type="entry name" value="SIDEROPHORE TRIACETYLFUSARININE C ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40841:SF2">
        <property type="entry name" value="SIDEROPHORE-DEGRADING ESTERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="381"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ87121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="431" mass="47613" checksum="BD68A3C75DC71E79" modified="2006-03-21" version="1">MASLGNWSFNPLPAFAPTVFPNIAMWDVNNTAKNLSYQVQISWPFEWESREVTDKSALTLYILDGNALGTTAAEAIKRRKLIYADQPDAVVVSVGYPLTNAVYDVARRNADFTPPLPPAAPSTGGPEPAGNGRADEFLAFLSGVLRPWVRGTVFPGVGFKRDALYGHSLGGLFVVYALVSEPAAFDTFVAASPGVGWNDGALLEEITQRFGDGLGGGEQFSARRRAETEENFQARKALYRWDHMTEWSHALYDRVRSGNGVSEVVLREYDGQDYSGWAGTVLTEAIEYFFEWDDTNLLVFGRNPEANVRQLEAAWETCIRWADSRGMKFAPEKSELIHFNKGRRQWTEQVNLTNPGGGTSPVKPEGSARFPEESWLDWKTSTGRPTLVASGKEAEEPRAMPCRGSWPKTWGNGASPKREKCTQSAIRSALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3C0</accession>
    <name>Q2H3C0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222940.1">
        <property type="nucleotide sequence ID" value="XM_001222939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3C0"/>
    <dbReference type="STRING" id="306901.Q2H3C0"/>
    <dbReference type="GeneID" id="4392160"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03726"/>
    <dbReference type="eggNOG" id="ENOG502SX5K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_322878_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3C0"/>
    <dbReference type="OrthoDB" id="4161727at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208905" description="C2H2-type domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="859"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="866"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="896" mass="97038" checksum="BFDADCBD77DEDC92" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3D1</accession>
    <name>Q2H3D1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_03715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222929.1">
        <property type="nucleotide sequence ID" value="XM_001222928.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4391767"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03715"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SMART" id="SM01111"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ87096.1"/>
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    </evidence>
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        <source>
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    <sequence length="1361" mass="154325" checksum="EF8F0FACC43449B5" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3Y2</accession>
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        <name evidence="2" type="ORF">CHGG_06633</name>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06633"/>
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            <end position="156"/>
        </location>
    </feature>
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        <location>
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            <end position="245"/>
        </location>
    </feature>
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        <location>
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            <end position="557"/>
        </location>
    </feature>
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        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
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        <location>
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            <end position="478"/>
        </location>
    </feature>
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        <location>
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            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="583" mass="63804" checksum="32784DE805EA0BA7" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="85" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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        </lineage>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
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                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ89825.1"/>
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        <property type="nucleotide sequence ID" value="XM_001222538.1"/>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Small_GTPase"/>
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        <property type="entry name" value="small_GTP"/>
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    </dbReference>
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        <property type="entry name" value="RHO FAMILY GTPASE"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
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        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ89825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="205" mass="22778" checksum="B88A50AF173AC750" modified="2006-03-21" version="1">MSTTQSIKCVVTGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSASVQVDGKPISLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLISPPSFDNVEAKWYPEISHHAPNVPIILVGTKLDKREDKETIDRLAANRMAPITFQMGAKRAGEIKAYKYVECSALTQMNLKTVFDNAIRGQARQKVLQVPGPVMPRPKRPKDLPILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4J6</accession>
    <name>Q2H4J6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_06419</name>
    </gene>
    <organism evidence="4 5">
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001222513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4J6"/>
    <dbReference type="GeneID" id="4390617"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06419"/>
    <dbReference type="eggNOG" id="ENOG502S9V3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_2_1_1"/>
    <dbReference type="InParanoid" id="Q2H4J6"/>
    <dbReference type="OMA" id="PVAVCHY"/>
    <dbReference type="OrthoDB" id="10259236at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004081">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006167">
        <property type="term" value="P:AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006754">
        <property type="term" value="P:ATP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051325">
        <property type="entry name" value="Nudix_hydrolase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340:SF0">
        <property type="entry name" value="BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE [ASYMMETRICAL]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340">
        <property type="entry name" value="DIADENOSINE 5,5-P1,P4-TETRAPHOSPHATE PYROPHOSPHOHYDROLASE MUTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="33"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ89800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="209" mass="23103" checksum="6BFEEDB5B5B5747E" modified="2006-03-21" version="1">MTRPQPLPGADEAELRLWLEEVDKSMSFRPASALGMSCGTVTIDPQHAMVLVIWNNRLKLHQLPKGRRNLNESMLSAALRETYEETGVRVTPLQLDVATRATPPKKAHADTSQKPPNITEGHPSNESIGACLYPDPQSETEALKIVYFFAATAECSAARDSGTQEEWEKLDAKWIPLSEVPSTLRFEAEVRAVAKTVADMKKSGYKIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5B6</accession>
    <name>Q2H5B6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_06149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222244.1">
        <property type="nucleotide sequence ID" value="XM_001222243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5B6"/>
    <dbReference type="GeneID" id="4390637"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06149"/>
    <dbReference type="eggNOG" id="ENOG502T4XR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_511901_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5B6"/>
    <dbReference type="OMA" id="IVSASCY"/>
    <dbReference type="OrthoDB" id="4588275at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="532" mass="57324" checksum="541D4B70DB660497" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5G1</accession>
    <name>Q2H5G1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_06104</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222199.1">
        <property type="nucleotide sequence ID" value="XM_001222198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5G1"/>
    <dbReference type="GeneID" id="4390743"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06104"/>
    <dbReference type="eggNOG" id="KOG0048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_707876_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5G1"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000016">
        <property type="entry name" value="Transcriptional activator Myb isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF199">
        <property type="entry name" value="MYB-LIKE TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="54"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="54"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="105"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="110"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="157"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ89485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="390" mass="42002" checksum="5A5616669449D638" modified="2006-03-21" version="1">MASSRTLISSPPDSPVAGQKPRQKDGPISWHKVACHLPGRNNKDCRKRWHYSIANTIRKGTWMREEDERLREAVELYGTRWSKIAEAVGTRNGDQCWKRWYDCLDPRIDKSPWTPEEDALLLHLVSQTGRNWSDIVHQHFPARTSLAAKNRYSILRRKQDGLPTSTSTSRGSSSVRHAKARTPGGVSRSPAPAPATPSLSSSPYLGVVATPSTTALSTPEPEVLGGGGGGGGVQGGDWMALAAAEIDEMLYRGAQGMGIGGGELDLDMELELDLDRGFGGLSTGWVQQQQPQGYQYQGLDSCQQAGGFDASLVDPRMQQEGYGNGEYYAAQGQQQLGVGGYGYDGSNMLGVYQGGVQIQVTQPGMYDGSSGLVGQSQMGSWQGGYAAGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H611</accession>
    <name>Q2H611_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6546 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221999.1">
        <property type="nucleotide sequence ID" value="XM_001221998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H611"/>
    <dbReference type="GeneID" id="4390148"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05904"/>
    <dbReference type="eggNOG" id="ENOG502SM97">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1704008_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H611"/>
    <dbReference type="OrthoDB" id="4584198at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046676">
        <property type="entry name" value="DUF6546"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20183">
        <property type="entry name" value="DUF6546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6546" evidence="1">
        <location>
            <begin position="47"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="154" mass="17523" checksum="0B2928E7BFAF338E" modified="2006-03-21" version="1">MAGLLVFDAPLRLQARLRRSFLKLWRWNHSIAQSKSANGGSSFRLDSLVPGEDPAKIEAVLQAAAAAAMRMPRLETMEIWNGGRGVAALFQYQALRRQEQAKIVWRGTWRLAPERCATQAWEAVMHQYAGRKLDWFRNSWMELSSSLTVMQSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H652</accession>
    <name>Q2H652_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SPT2 chromatin protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_05863</name>
    </gene>
    <organism evidence="4 5">
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EAQ89244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H652"/>
    <dbReference type="STRING" id="306901.Q2H652"/>
    <dbReference type="GeneID" id="4391083"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05863"/>
    <dbReference type="eggNOG" id="ENOG502SCZV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049218_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H652"/>
    <dbReference type="OMA" id="QHKKVEK"/>
    <dbReference type="OrthoDB" id="5430658at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013256">
        <property type="entry name" value="Chromatin_SPT2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08243">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00784">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
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        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ89244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="41726" checksum="579F5485B2261A84" modified="2006-03-21" version="1">MPILDLIASITGEKPSASSTPASRPSTALPKRKAEDDIRPAGTKVARVDSLSEKSSRPSGNSPRPSPRPADRPLGGSSDKAISKPQPALDKRSLTDKPNVHQVRAGSAGTRPSNGSKPLPSRPAPNRPSPTDSGPPKKRSYAEIMARAKANSEHRESLGKIQHKTVERNMTMKERKEMKVEDARKSKTGTRKPTTARSGPTSASFRDVAKSPGARGGLSGSANPKKTAPAEEKKVKKAALATTGYTGTARPRPGSSTVTKSGAASRPSSEGRPRDRPRYGGPVSSSRSRREEEDEMDDFIVDDEDEDEAPGYNTARQYRYDSYEEESDMEAGISDIEDEEQLADRQARREDLEQEALEKRLKREKEERRRRFLEATKSKAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6D7</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6D7"/>
    <dbReference type="GeneID" id="4390014"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05778"/>
    <dbReference type="HOGENOM" id="CLU_2621809_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6D7"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="78" mass="8838" checksum="B4FC5D8BE8DE9497" modified="2006-03-21" version="1">MTIATVKRDSSPVSSRALGTWQALVGFRSNRRNRDKAGFHSRRTELSKHHRQKERWETARGGFGDASRVPSRCGDDPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6H8</accession>
    <name>Q2H6H8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_05737</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
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    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
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                <person name="Untereiner W.A."/>
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                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221832.1">
        <property type="nucleotide sequence ID" value="XM_001221831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6H8"/>
    <dbReference type="STRING" id="306901.Q2H6H8"/>
    <dbReference type="GeneID" id="4391209"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05737"/>
    <dbReference type="eggNOG" id="KOG0772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014033_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H6H8"/>
    <dbReference type="OMA" id="KGDQYIT"/>
    <dbReference type="OrthoDB" id="10264376at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051858">
        <property type="entry name" value="WD_repeat_GAD-1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
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    </dbReference>
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        <location>
            <begin position="93"/>
            <end position="134"/>
        </location>
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        <location>
            <begin position="204"/>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="476"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ89118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="65516" checksum="A5EE986CF5FC3729" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6S7</accession>
    <name>Q2H6S7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221733.1">
        <property type="nucleotide sequence ID" value="XM_001221732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6S7"/>
    <dbReference type="STRING" id="306901.Q2H6S7"/>
    <dbReference type="GeneID" id="4389973"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05638"/>
    <dbReference type="eggNOG" id="ENOG502RXR7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025640_2_1_1"/>
    <dbReference type="InParanoid" id="Q2H6S7"/>
    <dbReference type="OMA" id="RLPWEWY"/>
    <dbReference type="OrthoDB" id="5422510at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032:SF1">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="506" mass="55979" checksum="E0D980C135A95E67" modified="2006-03-21" version="1">MASARPEAGSPAVSSSASSAPDSPGVLRNRKFGDRANPGAMRRSSTAGPPGPPGPRIPPPENYIHRRSSTFSQYSINEAVQDFHEEIADPGPEVNREPTTWKSLLPIMFASVPPIAGLFFENGTAFFSDLILLFLATIFLHWSVTAPWKWYSLAQQVREDNEPALEESLKAQDDESAIKSDSDSESVNGIHRSKVDKYDRTRQADEALDRLQSLEIMALATCFLAPAIATYLLYSVRYLLSPPSENLVSSFNLAIFLMAAEMPPVSHLIKMILARTLHLQRIVNANPYRVVSVTASNYRDLLARIQDLEARALEQSERPRCEGCDCIDGQKQQQTAKRLREDVARDVRAAVGPEIDGVVRAVRRYERKTSTLTSDTDHRLADLRQRLDDVIALSAVAARNNTGVWGLLETMAGGFWMVLSVPVAAALSLVSLLLSPIVKPLSWIAHQGRRSRTEAEERNHERGRKVVTNGQPQENSQARARSIKQGRAAPTFPAVFPPRPNRFKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6T7</accession>
    <name>Q2H6T7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_05628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221723.1">
        <property type="nucleotide sequence ID" value="XM_001221722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6T7"/>
    <dbReference type="GeneID" id="4390082"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05628"/>
    <dbReference type="eggNOG" id="ENOG502SYM4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_903148_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6T7"/>
    <dbReference type="OrthoDB" id="4589033at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF6">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="308" mass="34836" checksum="692338F36C3F9FFF" modified="2006-03-21" version="1">MALTDPPPDSASPATSRAAQASLLFRLPPPLRRRIYLYLGLESSPLVCDLDPQNGHALDVAGSVTAPLCDLFRPLRNRHVRLAKRPDSRLQEAARDAVMQARGIAAPYLKPSSTPAATSLMDLPRELRLQNLEYTDLIVPWREVTWSRQDLGYVAFATENSPRWGDVTCTPSLFNCWRIKGDGQSIGCFCRRYHSASSSACRCWLPPTPLFLVCRTLYQEALFVFFSSNEFFVHDLRSDPAWYDYPNERLAASLFLREVTPACALVHLRFLELVFPAYFAPSWPRAGQPAMQDWFATIDWLQDKINAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6Z2</accession>
    <name>Q2H6Z2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_05573</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2005-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Giovannoni S.J."/>
                <person name="Cho J.-C."/>
                <person name="Ferriera S."/>
                <person name="Johnson J."/>
                <person name="Kravitz S."/>
                <person name="Halpern A."/>
                <person name="Remington K."/>
                <person name="Beeson K."/>
                <person name="Tran B."/>
                <person name="Rogers Y.-H."/>
                <person name="Friedman R."/>
                <person name="Venter J.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 148.51</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2006-02" db="EMBL/GenBank/DDBJ databases">
            <title>Annotation of the Chaetomium globosum CBS 148.51 Genome.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Birren B."/>
                <person name="Lander E."/>
                <person name="Galagan J."/>
                <person name="Devon K."/>
                <person name="Nusbaum C."/>
                <person name="Ma L.-J."/>
                <person name="Jaffe D."/>
                <person name="Butler J."/>
                <person name="Alvarez P."/>
                <person name="Gnerre S."/>
                <person name="Grabherr M."/>
                <person name="Kleber M."/>
                <person name="Mauceli E."/>
                <person name="Brockman W."/>
                <person name="Rounsley S."/>
                <person name="Young S."/>
                <person name="LaButti K."/>
                <person name="Pushparaj V."/>
                <person name="DeCaprio D."/>
                <person name="Crawford M."/>
                <person name="Koehrsen M."/>
                <person name="Engels R."/>
                <person name="Montgomery P."/>
                <person name="Pearson M."/>
                <person name="Howarth C."/>
                <person name="Kodira C."/>
                <person name="Yandava C."/>
                <person name="Zeng Q."/>
                <person name="Alvarado L."/>
                <person name="Oleary S."/>
                <person name="Untereiner W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 148.51</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221668.1">
        <property type="nucleotide sequence ID" value="XM_001221667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6Z2"/>
    <dbReference type="FunCoup" id="Q2H6Z2">
        <property type="interactions" value="679"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H6Z2"/>
    <dbReference type="GeneID" id="4391130"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05573"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025000_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H6Z2"/>
    <dbReference type="OMA" id="NCAMSEM"/>
    <dbReference type="OrthoDB" id="8093034at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12619">
        <property type="entry name" value="RRM2_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12622">
        <property type="entry name" value="RRM3_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000117">
        <property type="entry name" value="Nuclear and cytoplasmic polyadenylated RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000134">
        <property type="entry name" value="Nuclear and cytoplasmic polyadenylated rna-binding pub1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038:SF1">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="38"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="119"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="245"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ88954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="413" mass="45721" checksum="BFE7A8E3224C9E19" modified="2006-03-21" version="1">MADNGLSLGLWPTPTAAAAPTRVRLATMNGQNPGSNPSHLPPPTSPYSRENTQIRFPDRGSLLRWAKGYNYGFVEYDDPGAAERAMQTLNGRRVHQSEIRVNWAYQSNSTNKEDTSNHFHIFVGDLSNEVNDEVLLQAFSAFGSVSEARVMWDMKTGRSRGYGFVAFRERPDAEKALSSMDGEWLGSRAIRCNWANQKGQPSMAQQQAMQQMGMTPTTPYGHHHFPTHGVHSYDMIVNQTPAWQTTCYVGNLTPYTTQQDIVPLFQNFGFVVESRFQADRGFSFVKMDTHENAAMAICQLNGYNVNGRPLKCSWGKDKTPSHPQQFDPNQQYSPQSAQTPGYPTTPSTYFNQYGSGTYPREAAAPNSVVNAPPMGYSGPPSAGGYGRGQQSNAQWNQPPPGQNFNNGFSGYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H777</accession>
    <name>Q2H777_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_05488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221583.1">
        <property type="nucleotide sequence ID" value="XM_001221582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H777"/>
    <dbReference type="GeneID" id="4389985"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05488"/>
    <dbReference type="HOGENOM" id="CLU_1651953_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H777"/>
    <dbReference type="OrthoDB" id="10330864at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ88869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="160" mass="17204" checksum="ECF6E0FF840D35E7" modified="2006-03-21" version="1">MSNVVVSSDASRSASDGRAESAALCERADRVGCFLTHGQTGSTTPRCLCMPFDARCWQPVSQRSDPGRVVNSIIQGPAMLGFPPEALHPNFAIRRSHRFGQSSQASQDPGEFQGPHCFPSVPSNPCVVHAPASTEPDSSLPLFLHPQLVQEVGCDRNPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7W5</accession>
    <name>Q2H7W5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_03689</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230205.1">
        <property type="nucleotide sequence ID" value="XM_001230204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7W5"/>
    <dbReference type="STRING" id="306901.Q2H7W5"/>
    <dbReference type="GeneID" id="4389836"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03689"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_4_1_1"/>
    <dbReference type="InParanoid" id="Q2H7W5"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF80">
        <property type="entry name" value="GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209337" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="139"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="281"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="4">
        <location>
            <begin position="514"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ91754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="669" mass="71753" checksum="A622957D664A698D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H843</accession>
    <name>Q2H843_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230127.1">
        <property type="nucleotide sequence ID" value="XM_001230126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H843"/>
    <dbReference type="GeneID" id="4389456"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03611"/>
    <dbReference type="eggNOG" id="ENOG502TAIP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1844849_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H843"/>
    <dbReference type="OMA" id="NATHINY"/>
    <dbReference type="OrthoDB" id="4575491at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208926" evidence="1">
        <location>
            <begin position="21"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="139" mass="14296" checksum="89C6BC7F6F2199D0" modified="2006-03-21" version="1">MQLSTIVAGAAALFSATTSASPVEARATSVNINPFALSCTATQCTWTLNYTLIPENTGAACSFVTSGGTIPTTIGTAIGPFACSPSDPNVRVRIQVVSGQYRLLISQVGSPTSNFDYFLPSSDFPGGNSYTGPSSFVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H853</accession>
    <name>Q2H853_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230117.1">
        <property type="nucleotide sequence ID" value="XM_001230116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H853"/>
    <dbReference type="GeneID" id="4389651"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03601"/>
    <dbReference type="eggNOG" id="ENOG502S854">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139257_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H853"/>
    <dbReference type="OMA" id="MDNDYKS"/>
    <dbReference type="OrthoDB" id="4357148at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11314" checksum="A53973613435A454" modified="2006-03-21" version="1">MTEAAPYQSDEKLGANLPREAPPGQVNDPSYKTRGTEAVPVVDDDAPVDDPMKPGRADTDKQLEQDEREAIDKSNILGERTRKAKPPGTYAEPSDEQMMGMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8J5</accession>
    <name>Q2H8J5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_03459</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229975.1">
        <property type="nucleotide sequence ID" value="XM_001229974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8J5"/>
    <dbReference type="STRING" id="306901.Q2H8J5"/>
    <dbReference type="PeroxiBase" id="4164">
        <property type="entry name" value="CgPGHS01"/>
    </dbReference>
    <dbReference type="GeneID" id="4389819"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03459"/>
    <dbReference type="eggNOG" id="KOG2408">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033051_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8J5"/>
    <dbReference type="OMA" id="ANWWGIV"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031408">
        <property type="term" value="P:oxylipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09818">
        <property type="entry name" value="PIOX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034815">
        <property type="entry name" value="A_dioxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF11">
        <property type="entry name" value="ALPHA-DIOXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0925">Oxylipin biosynthesis</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-0611">Plant defense</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ91524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="624" mass="69362" checksum="0B651806CF4A425B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9K0</accession>
    <name>Q2H9K0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_03104</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229620.1">
        <property type="nucleotide sequence ID" value="XM_001229619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9K0"/>
    <dbReference type="GeneID" id="4388959"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03104"/>
    <dbReference type="eggNOG" id="ENOG502SFDE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1081828_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9K0"/>
    <dbReference type="OrthoDB" id="3065412at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CFEM" evidence="10">
        <location>
            <begin position="160"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ91169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="257" mass="27685" checksum="8D4C78968907B6D7" modified="2006-03-21" version="1">MHHYDGNLLTAEDDNKFIAVFEISQKQQIFTAGFSPPVPDLAPTSIKLSFHDHDSLAGEHPFSDYIGPDRFEIAFEDSYLKIEGALDSPVSEKTTTCANTIRSIRAQSSASAKPQLRPSPPVCAPNQEPPTLSSFSFIEAKLQLAFTASGIDMHVLPSNCGGSPTKTLLVAAMAGLVAAQDVSKIPACAINCIMDTNPLSGCQSYPVLDFPCLCLTGEEYNTAIATCIVNACTDFNDVLAMIQWKTDTCALYGVKWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAC9</accession>
    <name>Q2HAC9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229341.1">
        <property type="nucleotide sequence ID" value="XM_001229340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAC9"/>
    <dbReference type="GeneID" id="4388502"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02825"/>
    <dbReference type="eggNOG" id="ENOG502S94T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036914_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HAC9"/>
    <dbReference type="OMA" id="QPRFKHA"/>
    <dbReference type="OrthoDB" id="5402392at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="520" mass="56985" checksum="9A8CC52B91A36553" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAI1</accession>
    <name>Q2HAI1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ethanolamine kinase</fullName>
            <ecNumber evidence="3">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_02773</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="3"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229289.1">
        <property type="nucleotide sequence ID" value="XM_001229288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAI1"/>
    <dbReference type="STRING" id="306901.Q2HAI1"/>
    <dbReference type="GeneID" id="4388734"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02773"/>
    <dbReference type="eggNOG" id="KOG4720">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012712_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HAI1"/>
    <dbReference type="OMA" id="FALIPKY"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ90838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="437" mass="49248" checksum="7057AC60020E448A" modified="2006-03-21" version="1">MAVGRENGHTKGAEENGDQHPIPSIALTYESTDPERSARRLVQVIRPDWRSPDSNIELVRFTEGITNTLFKIVNKRPGLSKSDIDKEAILLRAYGQGTDLIIDRHREAQNHELLMRHGLAPQLLLRFGNGMLYRFVPGAVTQPEDLRKPEIYKAVARRLAEWHAVVPCISARTGHSRKNSRVDGAVGVALDSNLGDDEFQLALDGVAPGKPPPNIWTVMQKWIFALPTETEAEIARQAELQQEFKKLVSELSHRPGLGVNGLVFAHCDLLSGNVIVLPKSQLANGDKSSEPTVAFIDYEYATPSPAAFDLANHFAEWGGFDCDYSVLPTRTQRREFISEYITSYFEKKKPGKSATVDKAAEIEQLLQEVDHYRGLPGFYWGIWALIQATISEIDFDYARYAETRLGEYYAWRAEVTGAREKSGQEMPLRERRWAQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBR7</accession>
    <name>Q2HBR7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">pectin lyase</fullName>
            <ecNumber evidence="7">4.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_02337</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.10" evidence="7"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228853.1">
        <property type="nucleotide sequence ID" value="XM_001228852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBR7"/>
    <dbReference type="GeneID" id="4388418"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02337"/>
    <dbReference type="eggNOG" id="ENOG502QXM6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021980_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HBR7"/>
    <dbReference type="OMA" id="RACLAKN"/>
    <dbReference type="OrthoDB" id="1637350at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047490">
        <property type="term" value="F:pectin lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000003">
        <property type="entry name" value="Pectin lyase F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF16">
        <property type="entry name" value="PECTIN LYASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209040" description="pectin lyase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="10">
        <location>
            <begin position="92"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ90402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="374" mass="39350" checksum="BAB54515493A6B8E" modified="2006-03-21" version="1">MRSFTLVSAVAALAHTVAAVTGAAEGFAKGVTGGGNASPVYPQSTSELVSYLGDSQARVIMLDRTFDFTGTEGTATEGGCAPWGTGSGCQTAINKNNWCNTEQPNAPKVNIKYDKAGVLGITVKSNKSLIGVGNKGIIKGKGIRMVSGTKNVIIQNIHITNLNPQYVWGGDAITLDNTDLIWIDHVTTSLVGRQHLVLGSNPSGRVTVSNCKFDGQTSWSATCNGYHYWGMYFTGSNDMITFQKNYIYHMSGRSPKVAGNTLLHAVNNYWHDSQGHSFELSGDAKVLVEGSVFQNVQTPLEAGGSGRLFASGSSSSACSQYLGRSCQANGFGSSGALSGSDTSFLTYFGGKNVAPATDYNTAKNVVNTAGFGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HC24</accession>
    <name>Q2HC24_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_02230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228746.1">
        <property type="nucleotide sequence ID" value="XM_001228745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HC24"/>
    <dbReference type="GeneID" id="4389160"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02230"/>
    <dbReference type="eggNOG" id="ENOG502SEV6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_25_1_1"/>
    <dbReference type="InParanoid" id="Q2HC24"/>
    <dbReference type="OrthoDB" id="4368687at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ90295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="14530" checksum="92AE59808637800A" modified="2006-03-21" version="1">MWSRKGLLTKAQSSLLSQARIGDIGLRDYLFRVKVPEVRTPYCECGRGRETVEHLVVWCPDPPLQRPWDGREIRSHRDLQTVLRGVGARSRRFVRKVLGWLMDSGRLLEYRLARRLELETVDGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HC31</accession>
    <name>Q2HC31_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1479 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228739.1">
        <property type="nucleotide sequence ID" value="XM_001228738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HC31"/>
    <dbReference type="GeneID" id="4389026"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02223"/>
    <dbReference type="eggNOG" id="ENOG502QWFN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011148_3_0_1"/>
    <dbReference type="InParanoid" id="Q2HC31"/>
    <dbReference type="OMA" id="DYIFWHP"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="829"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="863" mass="92191" checksum="74033E2D9FB37789" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HC35</accession>
    <name>Q2HC35_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_02219</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228735.1">
        <property type="nucleotide sequence ID" value="XM_001228734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HC35"/>
    <dbReference type="STRING" id="306901.Q2HC35"/>
    <dbReference type="GeneID" id="4389022"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02219"/>
    <dbReference type="eggNOG" id="KOG1812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004235_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HC35"/>
    <dbReference type="OMA" id="ACHEPHV"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
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            <begin position="12"/>
            <end position="39"/>
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        </location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
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        </source>
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        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ90284.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="916" mass="98717" checksum="3FE78AF0A4B2B500" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCI9</accession>
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            <taxon>Pezizomycotina</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="EAQ93830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="150" mass="17140" checksum="11D27948D598D75D" modified="2006-03-21" version="1">MVHISAQIEINRSPEEVRKVLLDFGHWPEWLTTGLSMTVVSPNHKLGPELQQGDRLRSDFKGTVVKPKVLENTPTKFEWRGRFGIILLVGHRRFFLKKSETTPGGTTLMQNEDIKGLLAFLFKKNEGHGKDAREAMTKFNEQLKARVESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCS3</accession>
    <name>Q2HCS3_CHAGB</name>
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        <recommendedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">CHGG_01981</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ93746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="26909" checksum="015A2E0D37F2DDF7" modified="2006-03-21" version="1">MVKGHFISSPPRGTSIVPSIHVRSLAPRRHLRLVRQNGMRFPTQPSSFRGPFRIRAPASGAVWKWKPWVAVAKEGPLRSPSQRISMQGWAARRCCNGGFPRPAMALAAPAAQISERLPLLDTEAATKKRYLEDLCNGMAEVKKPLLAAVEGAALGGGFELALMEAQSMGLVAELSQPGTVLDDAVKFANMLAQKSRASLSLAKEAICQVMGINIHDSKSNSPSNKALLSGWLGPNVHFKTQPLTVCPSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCX2</accession>
    <name>Q2HCX2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_01932</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001221152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCX2"/>
    <dbReference type="STRING" id="306901.Q2HCX2"/>
    <dbReference type="GeneID" id="4386488"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01932"/>
    <dbReference type="eggNOG" id="ENOG502QTJK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019940_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HCX2"/>
    <dbReference type="OMA" id="FTHETWR"/>
    <dbReference type="OrthoDB" id="3828420at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052427">
        <property type="entry name" value="Glycosyltrans_GT2/GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844:SF1">
        <property type="entry name" value="EXOSTOSIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844">
        <property type="entry name" value="SYNTHASE CPS1, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G02500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ93697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="53269" checksum="43615A0948428220" modified="2006-03-21" version="1">MASLMDIVIPRLDFLWSTKFWAIFHIIIWYGCFSRAQRASLVGTPQPSFRLSVSRRLTAYHRLHRYVAETLQMSNVGSSVEIDVLHVDKANKRLQVCKALEDDHVKTSITVMADDDVEWPSTLMPWLLAPFDNDDKMGGVGTCQRVKRVVDGDFMTRIFNWLGAAYIERRNFEISATHNIDGGTSCMSGRTGAYRTEILKSYSFLGSFKNEKWGRYILNADDDNFVTRWLVAHQWKTWIQYHPDCEIETTLENSPKFLYQCSRWARSNWRSNWTSLVHEKYVLTQQPWCTYALHIATFTSLAFLVDPLLLFSCWWGTESWELRNRYILLGAEIAFMFGFTKVVKLVGLFRKNPSDIMFLPVSIVFGYFHGLIKLWALCTLKQTSWGSREDGDEHNTFRLQEKPPRSQSMSTPYGPDLPKAMWHSRFSQNRRVAISSQKGDLIGCTVTAEVPFPKAAKAPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HD09</accession>
    <name>Q2HD09_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_01895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221116.1">
        <property type="nucleotide sequence ID" value="XM_001221115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HD09"/>
    <dbReference type="GeneID" id="4388129"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01895"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_6_1"/>
    <dbReference type="InParanoid" id="Q2HD09"/>
    <dbReference type="OMA" id="VDCLFLN"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF15">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_1G01330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ93660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="28637" checksum="A25D73DDF17B6963" modified="2006-03-21" version="1">MSFNYKRVLLVGATAGIGAAMADKLILEGIKVIAVGRRQERLDEFTGLALMRSLKGVQRPFQLSRPAQVDLDSFHDEMDINFSRHVDLSIKFLPHLLQKPFPTALIFTGSLLAAVPAVMVPAYSASKAALTAYVSCLRRQHPKSSTKIIEVWPPLVQSKPSPFLNLSQLLNTPSLPLANNINRLTTPPGELHDYMGKEAREMGIPVDVFTEQAWVQLAAGSELVMVGELGAGEGYEEMMRLRNGLFDALSDRMMTRFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HD11</accession>
    <name>Q2HD11_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Heavy metal tolerance protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_01893</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221114.1">
        <property type="nucleotide sequence ID" value="XM_001221113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HD11"/>
    <dbReference type="GeneID" id="4388127"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01893"/>
    <dbReference type="eggNOG" id="KOG0056">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_6_7_1"/>
    <dbReference type="InParanoid" id="Q2HD11"/>
    <dbReference type="OMA" id="DAYMAFI"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000041">
        <property type="term" value="P:transition metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18583">
        <property type="entry name" value="ABC_6TM_HMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF503">
        <property type="entry name" value="MITOCHONDRIAL POTASSIUM CHANNEL ATP-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="515"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="297"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="614"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="203"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="853"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="960"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1044"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="853"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="900"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="926"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="978"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1055"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1070"/>
            <end position="1080"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ93658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1114" mass="122285" checksum="4B6EA4E659170CDA" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDF4</accession>
    <name>Q2HDF4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_01750</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CybS family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220971.1">
        <property type="nucleotide sequence ID" value="XM_001220970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDF4"/>
    <dbReference type="FunCoup" id="Q2HDF4">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HDF4"/>
    <dbReference type="GeneID" id="4386788"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01750"/>
    <dbReference type="eggNOG" id="KOG4097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096618_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HDF4"/>
    <dbReference type="OMA" id="SEGSYHW"/>
    <dbReference type="OrthoDB" id="18577at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03496">
        <property type="entry name" value="SQR_TypeC_CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] cytochrome b small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ93515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="173" mass="18739" checksum="82A0499208648693" modified="2006-03-21" version="1">MASVARSSLLRQVASARPAFQQSVIARAARPTAITAFHTTARRDLLPPLPQHVDGTVNDAAPVPEPSPSHGSYHWTFDRLVAASLVPLTVAPFAAGSLNPTLDAFLCATILIHSHTGFQNVIIDYLPKKRVPRTRKAFMWGLNAATAVVGLALYEFETTDVGITETIKRIWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDM9</accession>
    <name>Q2HDM9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-chaperonin molecular chaperone ATPase</fullName>
            <ecNumber evidence="2">3.6.4.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_01675</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="2"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220896.1">
        <property type="nucleotide sequence ID" value="XM_001220895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDM9"/>
    <dbReference type="FunCoup" id="Q2HDM9">
        <property type="interactions" value="1305"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HDM9"/>
    <dbReference type="GeneID" id="4387887"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01675"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HDM9"/>
    <dbReference type="OMA" id="NIPPMQA"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000014">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000004">
        <property type="entry name" value="Heat shock protein SSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ93440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="620" mass="67074" checksum="FBE836A518E7E082" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDX3</accession>
    <name>Q2HDX3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_01581</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220802.1">
        <property type="nucleotide sequence ID" value="XM_001220801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDX3"/>
    <dbReference type="FunCoup" id="Q2HDX3">
        <property type="interactions" value="158"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HDX3"/>
    <dbReference type="GeneID" id="4386293"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01581"/>
    <dbReference type="eggNOG" id="KOG0005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010412_6_4_1"/>
    <dbReference type="InParanoid" id="Q2HDX3"/>
    <dbReference type="OMA" id="YAGKQMA"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01806">
        <property type="entry name" value="Ubl_NEDD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000023">
        <property type="entry name" value="NEDD8 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038738">
        <property type="entry name" value="Nedd8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="32"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ93346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="104" mass="11342" checksum="9EDB5E3AC6516635" modified="2006-03-21" version="1">MPPAPPPPSRLSWSREHPPPLLTDEPPPNRRVRTLTGKEIELDVEGSDQVSKIKDLVEEKEGIPPAQQRLIHGGKQMVDDKTADDYALVGGATLHLVLALRGGL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-04-20" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HE69</accession>
    <name>MTNB_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methylthioribulose-1-phosphate dehydratase</fullName>
            <shortName evidence="1">MTRu-1-P dehydratase</shortName>
            <ecNumber evidence="1">4.2.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MDE1</name>
        <name type="ORF">CHGG_01485</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-(methylsulfanyl)-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="1"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220706.1">
        <property type="nucleotide sequence ID" value="XM_001220705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HE69"/>
    <dbReference type="SMR" id="Q2HE69"/>
    <dbReference type="FunCoup" id="Q2HE69">
        <property type="interactions" value="219"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HE69"/>
    <dbReference type="GeneID" id="4387463"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01485"/>
    <dbReference type="eggNOG" id="KOG2631">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_4_0_1"/>
    <dbReference type="InParanoid" id="Q2HE69"/>
    <dbReference type="OMA" id="WFPGTSG"/>
    <dbReference type="OrthoDB" id="191080at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046570">
        <property type="term" value="F:methylthioribulose 1-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000003">
        <property type="entry name" value="Methylthioribulose-1-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03116">
        <property type="entry name" value="Salvage_MtnB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017714">
        <property type="entry name" value="MethylthioRu-1-P_deHdtase_MtnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027514">
        <property type="entry name" value="Salvage_MtnB_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03328">
        <property type="entry name" value="salvage_mtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640:SF7">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0486">Methionine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000393818" description="Methylthioribulose-1-phosphate dehydratase">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="258" mass="28868" checksum="AC1AE6957B2A033C" modified="2006-03-21" version="1">MTPPSNGQAAETNDHLVQSDNPEHPANLIPSLCAKFWTLGWVTGTGGGASIREDDLVYIAPSGVQKELMKASDIYVLSLAAQAQSLDRRNRVYLRSPPSYKPSQCTPLFLAAFTKRRAGCCIHTHSHWAVLVTLILETQGAGKDREFRINNIEQIKGFGKGFEKSGNLGYHDTLVIPVIENTAHEEDLTEFLEEAMDKYPDTYAVLVRRHGVYVWGDNVHKAKTQCESLDYLFQLAVEMKQLNLPWITDIEPVTPRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEB8</accession>
    <name>Q2HEB8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_01436</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220657.1">
        <property type="nucleotide sequence ID" value="XM_001220656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEB8"/>
    <dbReference type="STRING" id="306901.Q2HEB8"/>
    <dbReference type="GeneID" id="4387431"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01436"/>
    <dbReference type="eggNOG" id="KOG0114">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_25_2_1"/>
    <dbReference type="InParanoid" id="Q2HEB8"/>
    <dbReference type="OMA" id="HQPDKMV"/>
    <dbReference type="OrthoDB" id="275748at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12241">
        <property type="entry name" value="RRM_SF3B14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000286">
        <property type="entry name" value="Putative pre-mRNA branch site protein p14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034150">
        <property type="entry name" value="SF3B6_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF58">
        <property type="entry name" value="RNA-BINDING PROTEIN 19-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="13"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ93201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="115" mass="13319" checksum="58ACE222EA31C3AC" modified="2006-03-21" version="1">MSRANKLGPEVNRALFVKNLSYNVTPEELFDLFGKYGPIRQVRQGIASNTKGTAFVVYEDVMDAKQACDKLNGYNFQNRYLVVLYHQPDKMVRTKEDLDARKENLERLKHQHGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEB9</accession>
    <name>Q2HEB9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001220655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEB9"/>
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    </dbReference>
    <dbReference type="STRING" id="306901.Q2HEB9"/>
    <dbReference type="GeneID" id="4387047"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01435"/>
    <dbReference type="eggNOG" id="ENOG502S1HE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040321_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HEB9"/>
    <dbReference type="OMA" id="PWISKAG"/>
    <dbReference type="OrthoDB" id="431202at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022127">
        <property type="entry name" value="STIMATE/YPL162C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735:SF1">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12400">
        <property type="entry name" value="STIMATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="39602" checksum="8BF09FA135B2DCF4" modified="2006-03-21" version="1">MTSTNPTTTSLLPTAPTATGSPAGPTKPTECSLLGSFAIFVQLALGALALLSLVYKRWRERPQRPVKIWFFDASKQVFGSVLVHGANVFMSLLTSGKFSIEVDAGAVAANGVVRRMVGGLMGRAEEDVYVPNPCSFYLLNLGIDTTIGIPILIVIVRVLTKLVAYTPLGSPPESIQSGNYGTPPNAWWWLKQSLIYFCGLMGMKLVVLFMFMAFPWLPHVGDWALGWTEGNEKLQIVFVMMLFPLIMNALQYYIIDSYIKKQEAAAIDGEASTGTSGPIAYEELAISESEDSDDDEDDDVRKSVNAERSSHVRMERQDSVTGRPNREGEYDPDVDGDSPTIIGSSSSHISDRGTLPKPLLPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEJ3</accession>
    <name>Q2HEJ3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220582.1">
        <property type="nucleotide sequence ID" value="XM_001220581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEJ3"/>
    <dbReference type="GeneID" id="4387016"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01361"/>
    <dbReference type="HOGENOM" id="CLU_1547359_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HEJ3"/>
    <dbReference type="OrthoDB" id="4918060at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209253" evidence="1">
        <location>
            <begin position="21"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="173" mass="17066" checksum="21FAE6F0DCDA03CC" modified="2006-03-21" version="1">MAGLLTTFTLLSSWAVLLLAQNTPQNCIFSLVAEGNILGQAYEGVGGPACPADLGSGGSDSSSSSSSSSSGRYYYYLDLPEDMHRSGDACRTVRTDVGVLNGFVCNNEGGGEGGGATATVTATAAAGSGSSSSGEGAAGAGAVTTSWDGVVETVTLTVPGTFETVTVTRGEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HET3</accession>
    <name>Q2HET3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_01271</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220492.1">
        <property type="nucleotide sequence ID" value="XM_001220491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HET3"/>
    <dbReference type="FunCoup" id="Q2HET3">
        <property type="interactions" value="948"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HET3"/>
    <dbReference type="GeneID" id="4387383"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01271"/>
    <dbReference type="eggNOG" id="KOG1342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HET3"/>
    <dbReference type="OMA" id="EHRWDKH"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="81"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="416"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="434"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="523"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="551"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="583"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="639"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ93036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="670" mass="74509" checksum="27052DF81DD66A94" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HF54</accession>
    <name>Q2HF54_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220371.1">
        <property type="nucleotide sequence ID" value="XM_001220370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HF54"/>
    <dbReference type="SMR" id="Q2HF54"/>
    <dbReference type="STRING" id="306901.Q2HF54"/>
    <dbReference type="GeneID" id="4387472"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01150"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073129_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HF54"/>
    <dbReference type="OMA" id="SATCRCH"/>
    <dbReference type="OrthoDB" id="442087at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948:SF10">
        <property type="entry name" value="MRJ, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="50"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ92915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="312" mass="32894" checksum="77EE9548261A6279" modified="2006-03-21" version="1">MSCRLHGCRLQGTTPRPAQIDRDTEGPAGNSGPPWLAGNRICFPTPLTKGEDSILGISESASTSQIRDAYKRAALKTHPDRLPAEHPDRAARTRQFQLVNDAYYTLNDAGRRREYDAQRKLFASSSGSADGGRRAGRAGTAGAGTGGAGGQQMPGGFDFGEEDAFGEGGIPFSWAWNFFTGGQGQGQPGQPGRQGQEEARARTEDEQFADVFEEMLREEGMAAGQEGAAGGPAGKFWSLMGGLSGGALGFIVANVPGLVARRGGGESAGRGERCEGEERVCRVSVRQELPQTDRAKLLSQLAAKVLSHAVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFU5</accession>
    <name>Q2HFU5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sterigmatocystin biosynthesis monooxygenase stcW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220130.1">
        <property type="nucleotide sequence ID" value="XM_001220129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFU5"/>
    <dbReference type="GeneID" id="4386387"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00909"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_6_1_1"/>
    <dbReference type="InParanoid" id="Q2HFU5"/>
    <dbReference type="OMA" id="HSSIVYM"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF12">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="590" mass="65892" checksum="B58FD9D2A9A0BECA" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGP0</accession>
    <name>Q2HGP0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_00614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219835.1">
        <property type="nucleotide sequence ID" value="XM_001219834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGP0"/>
    <dbReference type="GeneID" id="4387168"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00614"/>
    <dbReference type="HOGENOM" id="CLU_1294244_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGP0"/>
    <dbReference type="OrthoDB" id="10366913at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ92379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="213" mass="24441" checksum="659E408624D13581" modified="2006-03-21" version="1">MSEEQQAVYSAHGRLQMLARYPGDPINAFEMLDLDPHAAPFSPPANSHWEGGEWYQAVHDKIRQRHMEMLERARAVEKRANGGEERHVSARGLQYQKAITMSASVLMRDGPRRYYLETFLPMLEKAIQGKRRECVWPLVQNFHRKECGDTGAIIGMTELRKPRNICDQGRGTERESDRIGGNEYIDFIAAVLTGIENPVRSLAETRRRSTFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGX8</accession>
    <name>Q2HGX8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxin/Ferlin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219747.1">
        <property type="nucleotide sequence ID" value="XM_001219746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGX8"/>
    <dbReference type="STRING" id="306901.Q2HGX8"/>
    <dbReference type="GeneID" id="4387879"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00526"/>
    <dbReference type="eggNOG" id="ENOG502S2MG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028361_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HGX8"/>
    <dbReference type="OMA" id="WQGVDNS"/>
    <dbReference type="OrthoDB" id="72441at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="49204" checksum="1E2E547DB93CC3C2" modified="2006-03-21" version="1">MPKIRHHRSSRRVPPPKDSDFDHEINLVDRDEEESPLRSSLGGPSTQDEAAGSTADRQGDVGEDEIGGEVTRQADAGQPSVRVEGPTPQVEASDPVLKAQSTKPHGKPKTPESAIDILYENQRGGFLCGIPLFSSMALGNLDPPAWTNFAHRPSPTDIGTAQVPDPSWEWAWPEWRINHDEGVDEDGWEYSFAFSKKFTWHKARWWNSFVRRRAWIRKRVKKDAGYSPQGPHLLNPEYFTIRPSSDLSGDGSPSEASSVRGSRASMATLNIEGAELHVIEHGDELLRVLRMSRIDREKIEAVDNYLKHAQESFEGLQSIMHDIMSLFVFQASRRVLLGKLTDLYDATVAEHKKETNPSLELDQKVKNLAAAVTHADEEVKRLEYWSDVKDIAEEGGSKGAVDQEQGWDSTWRGVDKSGPSAPPAPKHEAKKGIANNENENGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI35</accession>
    <name>Q2HI35_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="18">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CHGG_00119</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="17">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 18">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="18"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219340.1">
        <property type="nucleotide sequence ID" value="XM_001219339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HI35"/>
    <dbReference type="FunCoup" id="Q2HI35">
        <property type="interactions" value="377"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HI35"/>
    <dbReference type="GeneID" id="4387412"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00119"/>
    <dbReference type="eggNOG" id="KOG0204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_9_3_1"/>
    <dbReference type="InParanoid" id="Q2HI35"/>
    <dbReference type="OMA" id="ISIPWGA"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000031">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 18" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 18" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="444"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="979"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1052"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="156"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="20">
        <location>
            <begin position="261"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="21">
        <location>
            <begin position="923"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="123"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1142"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1143"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="1179"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1190"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1211"/>
            <end position="1225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EAQ91884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1236" mass="133647" checksum="1B11AD1C7F8D1EAE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GLX2</accession>
    <name>Q2GLX2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_11100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408039">
        <property type="protein sequence ID" value="EAQ82864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GLX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_11100"/>
    <dbReference type="eggNOG" id="ENOG502SADP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151458_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GLX2"/>
    <dbReference type="OMA" id="HTKTTPW"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043457">
        <property type="term" value="P:regulation of cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044792">
        <property type="entry name" value="TAR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47188">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47188:SF1">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ82864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="135" mass="15036" checksum="F6B77E93F3E78D0A" modified="2006-03-21" version="1">MLRFDDRFARQNRCEPPPEFPLASPYPSIVHHLSGPRLNAPTQIHPKTSGSVDDAPKLSPTFTFITRAGFTPKHSRKTLTPWSVFQDGSLMTITPASLQMREPRSPRGHYAPGYNTPGGATFPGPLSPRENRCWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM64</accession>
    <name>Q2GM64_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_10940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226207.1">
        <property type="nucleotide sequence ID" value="XM_001226206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GM64"/>
    <dbReference type="STRING" id="306901.Q2GM64"/>
    <dbReference type="GeneID" id="4397085"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10940"/>
    <dbReference type="eggNOG" id="KOG4618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_399544_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GM64"/>
    <dbReference type="OrthoDB" id="1874341at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051040">
        <property type="entry name" value="COX23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811:SF1">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="623"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="650"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ83122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="689" mass="77385" checksum="E7D4DF92B6A698D1" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM79</accession>
    <name>Q2GM79_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226192.1">
        <property type="nucleotide sequence ID" value="XM_001226191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GM79"/>
    <dbReference type="STRING" id="306901.Q2GM79"/>
    <dbReference type="GeneID" id="4397335"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10925"/>
    <dbReference type="eggNOG" id="ENOG502S3M0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055874_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GM79"/>
    <dbReference type="OMA" id="AHVVNNW"/>
    <dbReference type="OrthoDB" id="187522at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43264">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43264:SF1">
        <property type="entry name" value="INOSINE_URIDINE-PREFERRING NUCLEOSIDE HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="364" mass="39524" checksum="225F96AE6F9A2574" modified="2006-03-21" version="1">MAIGLESVLASGCNRKPIIIDTDLFSDVDDVGSLAIANVLQNYGVADLLGVVINSHSQYGALAASVVNTYFGNGNISIGAIRPLTNETFFDTYNFLRGEYAAKIAQHWPRQLNDSSATPTPVQLYRSILSAADDKSVTIISIGFLTNLAALLEDDGPDSRSLISAKVKELVVMGGQYPSGREFNFGGVDPASAHKAINNWPRQVPVTYIGFELGKDIFSGGRLTDSNAPTRSPVLAAYQWYVGRCSTLRESWDPITTLYGICGIEGCGELGMGKLFEFANDKGYNWVGEDGSNEWVNDTGAVNQHWLKLAEGVTNEDVAWWLDRFIGENPDGRRCPDLACDDAWDSAGFDDRDSFHVGQGNEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMM2</accession>
    <name>Q2GMM2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL27m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_10782</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ82964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226049.1">
        <property type="nucleotide sequence ID" value="XM_001226048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMM2"/>
    <dbReference type="STRING" id="306901.Q2GMM2"/>
    <dbReference type="GeneID" id="4397310"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10782"/>
    <dbReference type="eggNOG" id="KOG4600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_392316_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GMM2"/>
    <dbReference type="OrthoDB" id="1867012at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000042">
        <property type="entry name" value="50S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007062">
        <property type="entry name" value="PPI-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_bL27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL27M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04979">
        <property type="entry name" value="IPP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="274"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ82964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="703" mass="77786" checksum="236CF1004D8FEFC9" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMQ1</accession>
    <name>Q2GMQ1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_10753</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ82935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226020.1">
        <property type="nucleotide sequence ID" value="XM_001226019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMQ1"/>
    <dbReference type="FunCoup" id="Q2GMQ1">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GMQ1"/>
    <dbReference type="GeneID" id="4397169"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10753"/>
    <dbReference type="eggNOG" id="KOG0938">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026996_5_2_1"/>
    <dbReference type="InParanoid" id="Q2GMQ1"/>
    <dbReference type="OMA" id="VWKIPRI"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09251">
        <property type="entry name" value="AP-2_Mu2_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14836">
        <property type="entry name" value="AP2_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043532">
        <property type="entry name" value="AP2_Mu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043512">
        <property type="entry name" value="Mu2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0168">Coated pit</keyword>
    <keyword evidence="2" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="8">
        <location>
            <begin position="168"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ82935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="403" mass="45268" checksum="1E5AD8AAE2F3B7E3" modified="2006-03-21" version="1">MLSGILVFNQKGENLIFRAFRNDCRPRLADVFRIQVISNAQVRSPILTLGSTTFSHVKHENIYLVAITKSNANAALVFEFLYRLIQLGRGYFGKFDEEAVKNNFVLVYELLDEIIDFGYPQNTETDTLKMYITTEGVKTERAPEDSAKITMQATGALSWRKADVKYRKNEAFVDVIEDVNLLMSATGAVLRADVTGQIIMRAYLSGTPECKFGLNDRLLLDNDGLLSLPSGNRMGSKATKAAAGSVTLEDCQFHQCVKLGKFDSDRIISFVPPDGEFELMRYRSTENVNLPFKVHAIVNEVGKTKVEYSIGVRANFGSKLFATNVVVRIPTPLNTARITERCTQGKAKYEPSENNIVWKIGRFTGQSDSGLLVAYLKVFEKSNNSSFKWVRYITRAGSYETRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN15</accession>
    <name>Q2GN15_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228566.1">
        <property type="nucleotide sequence ID" value="XM_001228565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN15"/>
    <dbReference type="GeneID" id="4396024"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10639"/>
    <dbReference type="eggNOG" id="KOG4754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039184_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GN15"/>
    <dbReference type="OMA" id="ITHGVFM"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="23156" checksum="BD93AD4488CE2625" modified="2006-03-21" version="1">MSSTVYLVRHAESVHNVTKDFNLRDPGLTELGFTQAASLASFPALSSIAIVLTSPLTRAIETTIAGFGAIVDQSIGGETGGREGVARLILDPDLQERSDLPCDTGSDIGTLRARFPGLDVSALAEEWYVKEGAHAANDAAVAARARSVRERLQALARDLVDGGVPETKRAIVVVTHGVFMKFLAKDDTLDLPKAGWKAYTIGNGEESDRTGPVLTPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNK0</accession>
    <name>Q2GNK0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228381.1">
        <property type="nucleotide sequence ID" value="XM_001228380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNK0"/>
    <dbReference type="GeneID" id="4396804"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10454"/>
    <dbReference type="eggNOG" id="ENOG502T0H0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093582_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNK0"/>
    <dbReference type="OMA" id="KDRTEID"/>
    <dbReference type="OrthoDB" id="3348320at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="210" mass="23835" checksum="BC11E27561EEF756" modified="2006-03-21" version="1">MSVAPLRLISVGGSLAVRVCHNREASYDIDCILDPNIAAATDYLVELQRAISAVAEQGGYIEDWLNREVELFVSKDRRMDLFLESVQQGITIYEGANLVIYAGRLSWALERKVRRIAHARDRRGNKDVDVSDAAALVRLMRRAGEPPISFRYIRELNLNGFELPPTDEAIQEVAELYAEKYGEVGIADMIWDADTAKWKYQGLQNDWVWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPV0</accession>
    <name>Q2GPV0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227931.1">
        <property type="nucleotide sequence ID" value="XM_001227930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPV0"/>
    <dbReference type="GeneID" id="4395980"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10004"/>
    <dbReference type="eggNOG" id="ENOG502T8CZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1126839_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPV0"/>
    <dbReference type="OMA" id="ASMMGRD"/>
    <dbReference type="OrthoDB" id="4588611at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="278" mass="29377" checksum="8565A41D29B49C85" modified="2006-03-21" version="1">MAQVLPRLDTTNNQAMNRSRYVPNPVYSVNPYQQQQQQQQQYGALPQQAQLQGMMPGQAMPMHPSAYGSPPPGVGHSPMQTSMSPNTTWAANFANGPIIEDLCAPPPPMGMHASPPMNGMHPRMTMGPMHPGGMPQIQNVYGLRQPTPHPFAPQGMHPGQGQPTTMQGMPSARVMGTYPPYTGQQHGIGIVYPRPMDPNAMMVRPRLETAFANPVPTGPGGNAGLGMGQVASPNMGESPGGDGMQPLTPVEEALRGFSEPGFGGSGGFGASMMGRDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQC5</accession>
    <name>Q2GQC5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227756.1">
        <property type="nucleotide sequence ID" value="XM_001227755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQC5"/>
    <dbReference type="GeneID" id="4396816"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09829"/>
    <dbReference type="eggNOG" id="ENOG502R1TU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028280_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQC5"/>
    <dbReference type="OMA" id="AFHAHNS"/>
    <dbReference type="OrthoDB" id="68575at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF26">
        <property type="entry name" value="FMN REDUCTASE LOT6, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208491" description="Amine oxidase domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="53784" checksum="AD47501B32FB3CC9" modified="2006-03-21" version="1">MLSAIPVLAVLGYAAQTAASKASYRYASVADNYKGQYGEVIQRDVCVIGGGASGVHAAVSLKDKGKTVVVVERLNRLGGNTLTYVDSITGIPIDIGVVVFQPLPAVLRFFDKFKVPLANTSTLTANVPGQPANLSVPAPLYQTIQTYTDLRDGSGVNITRDDLSIGPALAGLAAVMAKYSYILDGFQTLPHPVPEDLVMPFGDFMTKHNLTAAIPIVFQVGQGLGSLLQLPTLYVIKYFNLGDVAALREGYLTQAQGNNSLLYVRAASYLGPSNILFESTVISANRRRTPSNRAELLVSARDGGVRLLSCAQILLTIPPTLSNLAGWDLTPDEHAVFSQLTGATGYWTGLVRGVGLNQTVAHQNAAATTPFQLPVLPALYQVAAVGVLEDVWWVKLGADTATLPDEQVRARAVREMQRVQAAQGVPVTEPEWLMFDSHAPFMLHAGAEVIRGGFYKRLAGLQGGLGGRMFYSGAAFHTHYSGYLWRYNEDVVIPMMTRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQF7</accession>
    <name>Q2GQF7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227724.1">
        <property type="nucleotide sequence ID" value="XM_001227723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQF7"/>
    <dbReference type="GeneID" id="4396531"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09797"/>
    <dbReference type="eggNOG" id="ENOG502RIZQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_990456_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQF7"/>
    <dbReference type="OrthoDB" id="4580735at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="281" mass="31164" checksum="23EF310E437B5DCD" modified="2006-03-21" version="1">MAPTGPSESRTSSPAANPPATNPVAAVLPGMRPPGWRWPWPADVPDPERPKSCLKSAGATRQVLPIRFADDARCLVSGSPVPPHPITRPEWMKALAHARFVQAFRSGRTQQEVVDDIETIDPRRVAHTKWQGTRRVRWLLDPEHIDPWDAEALVFRLLFRRSRKHMLQNMAGYPIRSRRDRDKHPALGSPEPELETEQGPDPPRKCSRNGQAPTQRPIEPPSLPTARGVVSSSTLVDSGTGGVKPVVCPWAQLPSHPLPILRASCSNNRIPMIAIYQAKLQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-02-10" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQG8</accession>
    <name>KMO_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Kynurenine 3-monooxygenase</fullName>
            <ecNumber evidence="1">1.14.13.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Biosynthesis of nicotinic acid protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Kynurenine 3-hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BNA4</name>
        <name type="ORF">CHGG_09786</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:20545"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aromatic-ring hydroxylase family. KMO subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.9" evidence="1"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227713.1">
        <property type="nucleotide sequence ID" value="XM_001227712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQG8"/>
    <dbReference type="SMR" id="Q2GQG8"/>
    <dbReference type="FunCoup" id="Q2GQG8">
        <property type="interactions" value="677"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GQG8"/>
    <dbReference type="GeneID" id="4397066"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09786"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023210_2_1_1"/>
    <dbReference type="InParanoid" id="Q2GQG8"/>
    <dbReference type="OMA" id="REFMFIA"/>
    <dbReference type="OrthoDB" id="10053569at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004502">
        <property type="term" value="F:kynurenine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070189">
        <property type="term" value="P:kynurenine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000129">
        <property type="entry name" value="Kynurenine 3-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01971">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027545">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028:SF2">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword id="KW-0503">Monooxygenase</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000361925" description="Kynurenine 3-monooxygenase">
        <location>
            <begin position="1"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03018"/>
        </source>
    </evidence>
    <sequence length="479" mass="53914" checksum="703C8A8F0FD0DE5C" modified="2006-03-21" version="1">MEKKQKVVVVGAGPVGSLAALYAANRGDDVEIYELRSDLRDPTTTPLNFTKSINLALSERGINAMRHAGQPKLIEHVMGATIPMHGRMIHGKRANGDLFEESQNYDVYGRSILAVDRGRLNERLLDILEAMPNVTFFFNHKLTGADFRKNKAWFEVRDKTGAAQGQQSREIEVKFDLMIGTDGAHSAVRYHMMKYTRMDYEQVYIDTMWCEFQIQPKTVVPDAPLDSKFSISPNHLHIWPGKEFMFIAIPSDDGSFTCTLFAPATLYEHLESDRTGSLVPPFFDKYFPGVTTLIPPTELIDSFHRNPHLPLISIKCKPHHYGSSVVILGDAAHAMVPFYGQGMNAGLEDVRILFDILDKHARMDELSACADRAVSREHALAEYTAVRVPDAHAINDLALQNYVEMRASVLSPVYRLRKFLEEALSKYVPSLGWQTKYARVSFGNERYSEVVAKSEHQGKMLVRGIGILSCRVGRALHNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRK5</accession>
    <name>Q2GRK5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_09399</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227326.1">
        <property type="nucleotide sequence ID" value="XM_001227325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRK5"/>
    <dbReference type="FunCoup" id="Q2GRK5">
        <property type="interactions" value="593"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GRK5"/>
    <dbReference type="GeneID" id="4394932"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09399"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_14_2_1"/>
    <dbReference type="InParanoid" id="Q2GRK5"/>
    <dbReference type="OMA" id="LNQWLHF"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF20">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 1 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="96"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ85385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="259" mass="29705" checksum="0D197920441B4B7A" modified="2006-03-21" version="1">MTSTSNPAKPIRVWITPPGPNSWKTVFILEELGINYEFKSFRFDDVKKKPFIDVNPNGRVPAIEDPNTGITLWESGAINQYLVEVYDTDKRLTHAGLKERHLCNQYLQFQMSGQGPYYGQAGWFQHLHPEKIPSAVERYTKEIRRVLTVLEGILAAQPPAADGGEVRWLVGGKMTYADMAFAPWDFRLSEVLMQSWDEVWEGVPHVRAWHEAMVGLPSWKRAMEHRARLMDEQGLQWNGVPKGIETFTEYEEKIAKGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRS1</accession>
    <name>Q2GRS1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227260.1">
        <property type="nucleotide sequence ID" value="XM_001227259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRS1"/>
    <dbReference type="GeneID" id="4395528"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09333"/>
    <dbReference type="eggNOG" id="ENOG502SK62">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053383_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GRS1"/>
    <dbReference type="OMA" id="YTFWVAV"/>
    <dbReference type="OrthoDB" id="5428890at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="361" mass="41646" checksum="3EDDE2802558B5ED" modified="2006-03-21" version="1">MTMDAIALLDADALDLVSLLWQPSSSGTGELFNGDTESKLGHEAYCDYFRRQWHLLAIYGDHQPAASRSPQAIARLMEHIRDGKPREEMMDMLRLAGAEEEACERSLNLAVRLLVMMRFGLAKHQVAPRRFLRWEQGSLQTFIHGVFNEVPKLSSEQIRLPKSFDAWSIANIAGIKLAFTDNLADHLLLVDDDTRLLIFHHASFLEYHRSKTSVFPDDLINETLRTLALLFPQAAFSNQQRTRTPRRKWLQGLRVKHRETQHTVIDPRLALCGTPQGEDRQIERFRFWRDRLVILKQTYDDATPKTLGQWWRDRRNGVQWYTFWVAILVLAITTFLGVVQAIEGALQVYKAYYPTEAVSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSE5</accession>
    <name>Q2GSE5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polyubiquitin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_09109</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227036.1">
        <property type="nucleotide sequence ID" value="XM_001227035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSE5"/>
    <dbReference type="SMR" id="Q2GSE5"/>
    <dbReference type="FunCoup" id="Q2GSE5">
        <property type="interactions" value="572"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GSE5"/>
    <dbReference type="GeneID" id="4394920"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09109"/>
    <dbReference type="eggNOG" id="KOG0001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010412_7_0_1"/>
    <dbReference type="InParanoid" id="Q2GSE5"/>
    <dbReference type="OMA" id="VHENTRR"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000004">
        <property type="entry name" value="Polyubiquitin Ubiquitin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="UBIQUITIN_1"/>
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    </dbReference>
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        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
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        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="153"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="229"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ85095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="305" mass="34301" checksum="F42BBF708CA6276A" modified="2006-03-21" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSM0</accession>
    <name>Q2GSM0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_09034</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001226960.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2GSM0">
        <property type="interactions" value="1105"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GSM0"/>
    <dbReference type="GeneID" id="4394859"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09034"/>
    <dbReference type="eggNOG" id="KOG4674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001250_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSM0"/>
    <dbReference type="OMA" id="HAQQNYE"/>
    <dbReference type="OrthoDB" id="343070at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.950">
        <property type="entry name" value="Methyl-accepting chemotaxis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057974">
        <property type="entry name" value="NUA/TPR/MLP1-2-like_dom"/>
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        <property type="entry name" value="Nucleoprot-TPR/MLP1-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057577">
        <property type="entry name" value="Nucleoprot-TPR/MLP1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898:SF2">
        <property type="entry name" value="NUCLEOPROTEIN TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898">
        <property type="entry name" value="NUCLEOPROTEIN TPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25481">
        <property type="entry name" value="Nucleoprot-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25785">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR_MLP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
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    <feature type="domain" description="Nucleoprotein TPR/MPL1" evidence="7">
        <location>
            <begin position="163"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="NUA/TPR/MLP1-2-like" evidence="8">
        <location>
            <begin position="463"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoprotein TPR/MLP1-2" evidence="6">
        <location>
            <begin position="1024"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1153"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="1471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1778"/>
            <end position="2004"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="129"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="203"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
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            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
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            <end position="490"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="552"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1192"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1554"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1656"/>
            <end position="1670"/>
        </location>
    </feature>
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        <location>
            <begin position="1787"/>
            <end position="1820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
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            <end position="1838"/>
        </location>
    </feature>
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        <location>
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            <end position="1865"/>
        </location>
    </feature>
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        <location>
            <begin position="1877"/>
            <end position="1919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1927"/>
            <end position="1967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ85020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="2004" mass="223352" checksum="25D84E1F999A3BB5" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSP6</accession>
    <name>Q2GSP6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Neutral ceramidase</fullName>
            <ecNumber evidence="4">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_09008</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the neutral ceramidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="4"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226935.1">
        <property type="nucleotide sequence ID" value="XM_001226934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSP6"/>
    <dbReference type="STRING" id="306901.Q2GSP6"/>
    <dbReference type="GeneID" id="4395445"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09008"/>
    <dbReference type="eggNOG" id="KOG2232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011300_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GSP6"/>
    <dbReference type="OMA" id="WTQVRSD"/>
    <dbReference type="OrthoDB" id="191371at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="entry name" value="Neutral/alkaline non-lysosomal ceramidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670:SF20">
        <property type="entry name" value="NEUTRAL CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
        <property type="entry name" value="Ceramidse_alk_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase N-terminal" evidence="6">
        <location>
            <begin position="73"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase C-terminal" evidence="7">
        <location>
            <begin position="621"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="724"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="728"/>
            <end position="746"/>
        </location>
    </feature>
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        <location>
            <position position="277"/>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ84994.1"/>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="753" mass="81335" checksum="20C025EDD5F54BBB" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GT85</accession>
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        <name type="common">Soil fungus</name>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="178" mass="19597" checksum="8B2B8F5FBAB3F2C4" modified="2006-03-21" version="1">MAAPQQQQPAAAAGPINNDDIADWTARLNDVLARPGEYVNSKSPATAQPWYNSFFGCFAPIDTCLMSWCCPCVVFGRTHHRMRKGANLEGYEPINTSCLLFCASSCVALWWVPMAMQRADMRTKYNLEGNCIFDMVTACCCNCCQLAQADKEAAHREPLLVQQGYQAQAGMAFPGAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GT97</accession>
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    </dbReference>
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    </dbReference>
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    <proteinExistence type="predicted"/>
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        <location>
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            <end position="920"/>
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            <end position="38"/>
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    </feature>
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        <location>
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    </feature>
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        <location>
            <begin position="887"/>
            <end position="902"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ84793.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1146" mass="122271" checksum="1DC7C51053C6377A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU69</accession>
    <name>Q2GU69_CHAGB</name>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">CHGG_08485</name>
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    <organism evidence="7 8">
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="GeneID" id="4395165"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08485"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_410481_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GU69"/>
    <dbReference type="OrthoDB" id="2639200at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="101"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
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            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
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            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ84471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="645" mass="73448" checksum="0533D48D6DF5C05E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUA4</accession>
    <name>Q2GUA4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226377.1">
        <property type="nucleotide sequence ID" value="XM_001226376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUA4"/>
    <dbReference type="GeneID" id="4395844"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08450"/>
    <dbReference type="eggNOG" id="ENOG502RUNP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_7_4_1"/>
    <dbReference type="InParanoid" id="Q2GUA4"/>
    <dbReference type="OMA" id="WFPAPRA"/>
    <dbReference type="OrthoDB" id="4576069at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="58"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="668" mass="75300" checksum="77EE231BF2845530" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV23</accession>
    <name>Q2GV23_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225837.1">
        <property type="nucleotide sequence ID" value="XM_001225836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV23"/>
    <dbReference type="GeneID" id="4393406"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08181"/>
    <dbReference type="HOGENOM" id="CLU_3191263_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GV23"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="46" mass="4904" checksum="70501336C77D019F" modified="2006-03-21" version="1">MTGHILVIQNGPPQGLQANRRHHLAAAPPGRTQSFEKRAGGAKVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVD9</accession>
    <name>Q2GVD9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">CHGG_08065</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225721.1">
        <property type="nucleotide sequence ID" value="XM_001225720.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4394528"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08065"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000879_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GVD9"/>
    <dbReference type="OrthoDB" id="5106181at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="13" id="KW-0229">DNA integration</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="14" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="19" id="KW-0862">Zinc</keyword>
    <keyword evidence="19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="21">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A2" evidence="22">
        <location>
            <begin position="637"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="23">
        <location>
            <begin position="1055"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="1675"/>
            <end position="1832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="24"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="341"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1947"/>
            <end position="2034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="349"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1998"/>
            <end position="2009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EAQ86812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="2034" mass="229387" checksum="DD0A45DA046FCD3A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVK9</accession>
    <name>Q2GVK9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="6">26S proteasome regulatory subunit rpn-8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_07995</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225651.1">
        <property type="nucleotide sequence ID" value="XM_001225650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVK9"/>
    <dbReference type="FunCoup" id="Q2GVK9">
        <property type="interactions" value="977"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GVK9"/>
    <dbReference type="MEROPS" id="M67.973"/>
    <dbReference type="GeneID" id="4393283"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07995"/>
    <dbReference type="eggNOG" id="KOG1556">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027018_3_0_1"/>
    <dbReference type="InParanoid" id="Q2GVK9"/>
    <dbReference type="OMA" id="HAMSIKT"/>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000004">
        <property type="entry name" value="26S proteasome regulatory subunit rpn-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="16"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="303"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="306"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ86742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="353" mass="39071" checksum="7F31554C7F931225" modified="2006-03-21" version="1">MPATTAETLSLVTRNVSVAPLVLLSVVDHYNRTEAFKSKTKRVVGVLLGQNDGKNVRVSNSFAVPFEEDDKDPSVWFLDHNYVESMNEMFKKVNAREKLIGWYHSGPKLRASDLEINELFKRYTPNPLLVIIDVQPKESGVPTDAYFAVEEIKDDGTTTSKTFVHTPTIIEAEEAEEIGVEHLLRDIRDVAVGTLSTRVTNQLQSLQGLHLRLRDIQAYLQKVLDGQLPVNHAILGNLQDVFNLLPNLSTPKSGAAANGAKGDTELNYAMSVKSNDQLMAIYLSSLIRAITAFHDLIENKIQNRQQQEEKEAAKKEGENGAKEGEKKEGSPASGDSKESGGDKEKEGSKDKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVZ7</accession>
    <name>Q2GVZ7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225513.1">
        <property type="nucleotide sequence ID" value="XM_001225512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVZ7"/>
    <dbReference type="GeneID" id="4393934"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07857"/>
    <dbReference type="HOGENOM" id="CLU_1266732_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GVZ7"/>
    <dbReference type="OrthoDB" id="10350943at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="218" mass="24116" checksum="298945476D5F498B" modified="2006-03-21" version="1">MGVEIPERRREVSVLVHLGVAPSRCERGKLGEARCSMSGRDPCQDREANQRQTRPLDTLTPWRWEEQGLTSSTPTPVGLNSCNRALENGRKGRKKATGGEGGGDRESSKTTTQSMGMVLRGVQWDTLSRHPCTAHLKWGVKHCSFCSGSLHAKQVLAQYLHCPGLDHDTPRNAPETSTGDDDDEQASSAMRHQDRYEDGEVLRVMRGQTSLCFASLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWB9</accession>
    <name>Q2GWB9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_07735</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225391.1">
        <property type="nucleotide sequence ID" value="XM_001225390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWB9"/>
    <dbReference type="FunCoup" id="Q2GWB9">
        <property type="interactions" value="395"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GWB9"/>
    <dbReference type="GeneID" id="4393383"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07735"/>
    <dbReference type="eggNOG" id="KOG2115">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003094_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GWB9"/>
    <dbReference type="OMA" id="QKQAVML"/>
    <dbReference type="OrthoDB" id="10259024at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019515">
        <property type="entry name" value="VPS54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10475">
        <property type="entry name" value="Vps54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
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</entry>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ86390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="534" mass="56944" checksum="F69DEE8794DFA5D8" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-09-13" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWS5</accession>
    <name>Q2GWS5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall protein PhiA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225235.1">
        <property type="nucleotide sequence ID" value="XM_001225234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWS5"/>
    <dbReference type="GeneID" id="4393966"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07579"/>
    <dbReference type="HOGENOM" id="CLU_1677669_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWS5"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209087" description="Cell wall protein PhiA" evidence="1">
        <location>
            <begin position="21"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="16709" checksum="A359F282812A44B5" modified="2006-03-21" version="1">MQLPSVLLPAIALLAQTASSFLLSSPHDTVTSEDFAKNQGLRIGFYRFNTGPTAAFVLDDDGNLNMKSHPHVAFFDRGGGLWRLEFGSPNTPGAPKSIKGPFATEGGLFKYKGEGGFEWYLCNDGSSGLDIVLGAPRLDVETNGCIAGVDLIVEDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX22</accession>
    <name>Q2GX22_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225138.1">
        <property type="nucleotide sequence ID" value="XM_001225137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX22"/>
    <dbReference type="STRING" id="306901.Q2GX22"/>
    <dbReference type="ESTHER" id="chagb-q2gx22">
        <property type="family name" value="Dienelactone_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="4393506"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07482"/>
    <dbReference type="eggNOG" id="KOG3043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_2_1_1"/>
    <dbReference type="InParanoid" id="Q2GX22"/>
    <dbReference type="OMA" id="HPSMLEK"/>
    <dbReference type="OrthoDB" id="10019231at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF55">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G01900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="37"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="250" mass="26569" checksum="8802C7893865EAFF" modified="2006-03-21" version="1">MATTSTPQLSTCCLQASLWEGTPTGTETTLDGVPNPTYIAYPPSTTTTANAILYIHDLLGWTFPNARLAADALARATNATVYLPDFLGGEVIDFDAALAGRFHELDMPGLKARNAREVREPEVLAYARVLREVYKGGRVGVVGYCYGGWAALRVGGEEFAGEFGGRGLVDCVAVGHPSMLVPGDVEGLRVPVQFLAPELDEVFTAELKLLAFTALQKSGVPFDYQHFPGVTHGCLQRGNADAKGGEGGYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX35</accession>
    <name>Q2GX35_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coagulation factor 5/8 type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225125.1">
        <property type="nucleotide sequence ID" value="XM_001225124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX35"/>
    <dbReference type="STRING" id="306901.Q2GX35"/>
    <dbReference type="GeneID" id="4393388"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07469"/>
    <dbReference type="eggNOG" id="ENOG502TG6Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_912188_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GX35"/>
    <dbReference type="OMA" id="WGLDAVN"/>
    <dbReference type="OrthoDB" id="5186230at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208701" description="Coagulation factor 5/8 type domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="31954" checksum="07D8DD828BFCC9EB" modified="2006-03-21" version="1">MNLPALLRALLLHTLLTTTLAASPIRSIFLFKDVLKSNTTALTTSGFNTFIIFGVGVLPNGDIMYYSNTPGSSDVLLASGGAYVGGDALAAKVQSFKTASGTLINRVEICMNAQNIRQLMASPGPGATTPLYRNFAALRAAWGLDAVNNDDESIYDSASTVAFARMLGAIGYRYTIAPYDAGRLGFWAGVVSGVNSGESKGLLDRVYLQLYDGGARNVPASWQTALGMKVVPILWVVNDSKPQFGQSPAQVRSRLAQWSREAQVAGGGLWNDYDIEKMGLASASYAEYGYVLKEVFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GY73</accession>
    <name>Q2GY73_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_07081</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224737.1">
        <property type="nucleotide sequence ID" value="XM_001224736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GY73"/>
    <dbReference type="FunCoup" id="Q2GY73">
        <property type="interactions" value="517"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GY73"/>
    <dbReference type="GeneID" id="4393809"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07081"/>
    <dbReference type="eggNOG" id="KOG0315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_5_1"/>
    <dbReference type="InParanoid" id="Q2GY73"/>
    <dbReference type="OMA" id="VQRNYKH"/>
    <dbReference type="OrthoDB" id="400at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000339">
        <property type="entry name" value="WD-repeat protein pop3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF0">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="71"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="112"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="190"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="244"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ85828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="305" mass="33789" checksum="4806D53549F4A11F" modified="2006-03-21" version="1">MSVILCTAGYDHTIRFWEALSGICSRTIQHPDSQVNRLCISPDKRHLAAAGNHTVKLFDVRSTNPAPTSVFEGHTGNITGVAFHCDGKWMVTSSEDGTVKIWDTRTGVIQRSYDHGSPVNDVVIHPNQGEIISCDRSGSIRLWDLAENTCAHQLIPEEEVSVSSVTVATDGTLLCAANNARTQLVPMTHFSAHKEYITRILLSPDVKKLATCSADHTAKIWEVKEMEPAGPNAEPRAFPLEATLTGHQRWVWDCAFSADSAYLVTACSDHYARLWELHTQQIIRQYNGHHRGAVCVALNDYSETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GY88</accession>
    <name>Q2GY88_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Upf1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_07066</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs. Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224722.1">
        <property type="nucleotide sequence ID" value="XM_001224721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GY88"/>
    <dbReference type="FunCoup" id="Q2GY88">
        <property type="interactions" value="1075"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GY88"/>
    <dbReference type="GeneID" id="4394128"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07066"/>
    <dbReference type="eggNOG" id="KOG1802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001666_4_0_1"/>
    <dbReference type="InParanoid" id="Q2GY88"/>
    <dbReference type="OMA" id="QYMQMNG"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21407">
        <property type="entry name" value="1B_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18039">
        <property type="entry name" value="DEXXQc_UPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21400">
        <property type="entry name" value="ZBD_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.230:FF:000003">
        <property type="entry name" value="Regulator of nonsense transcripts 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000097">
        <property type="entry name" value="Regulator of nonsense transcripts 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040812">
        <property type="entry name" value="UPF1_1B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018999">
        <property type="entry name" value="UPF1_CH/ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF364">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18141">
        <property type="entry name" value="UPF1_1B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09416">
        <property type="entry name" value="UPF1_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51997">
        <property type="entry name" value="UPF1_CH_RICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Upf1" evidence="17">
        <location>
            <begin position="70"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="C4" evidence="15">
        <location>
            <begin position="140"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="882"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="963"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ85813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1071" mass="117177" checksum="DA61E310198C23FC" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GY93</accession>
    <name>Q2GY93_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_07061</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="10"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224717.1">
        <property type="nucleotide sequence ID" value="XM_001224716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GY93"/>
    <dbReference type="FunCoup" id="Q2GY93">
        <property type="interactions" value="510"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GY93"/>
    <dbReference type="GeneID" id="4394381"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07061"/>
    <dbReference type="eggNOG" id="KOG2803">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031246_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GY93"/>
    <dbReference type="OMA" id="QCKYINA"/>
    <dbReference type="OrthoDB" id="40021at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02173">
        <property type="entry name" value="ECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="24"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="404"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ85808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="434" mass="48390" checksum="DBB8C1E713D7C112" modified="2006-03-21" version="1">MSATENVLPPGDPAPELLDGRLWVDGCFDFFHHGHAGAVVQARQLGDELYVGVHSDEAILENKGPTVMNLKERLLAIDACRWVTKSIAHAPYVTQLDWISHFGCRYVVHGDDITSDSGGEDCYRFVKAADRFRVVKRTPSISTTDLVGRMLLCTRGHFIHSLERTLAGLEGPGTEAERRAEGQAMTERVRLYATDETAKRAGADVWFWGADNGFRELFKGVGPKPGQRVVYVDGGFDLFSSGHIEFLRLVTEAEEELARKDGWYSEQAVDERKGKGADYGPVFVVAGVHDDEVINKWKGVNYPIMNIYERGLCVLQCRYVNAVIFGAPFTPTKSYLTSLPWGTPDAVYHGPTSFMPFTEDVYTEPKEMSIYREIGHHEFEDVNAGTIVQRIMKSRDLYEARQKAKEMKARSRSCPQGARVARGRAAQEGGGAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYH7</accession>
    <name>Q2GYH7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sphingolipid delta(4)-desaturase</fullName>
            <ecNumber evidence="8">1.14.19.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_06977</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Delta(4)-fatty-acid desaturase which introduces a double bond at the 4-position in the long-chain base (LCB) of ceramides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:46544"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:31488"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="1.14.19.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.17" evidence="8"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224633.1">
        <property type="nucleotide sequence ID" value="XM_001224632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYH7"/>
    <dbReference type="STRING" id="306901.Q2GYH7"/>
    <dbReference type="GeneID" id="4393246"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06977"/>
    <dbReference type="eggNOG" id="KOG2987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032156_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GYH7"/>
    <dbReference type="OMA" id="GATCNQN"/>
    <dbReference type="OrthoDB" id="200948at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03508">
        <property type="entry name" value="Delta4-sphingolipid-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011388">
        <property type="entry name" value="DES1/DES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013866">
        <property type="entry name" value="Sphingolipid_d4-desaturase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879">
        <property type="entry name" value="SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879:SF8">
        <property type="entry name" value="SPHINGOLIPID DELTA(4)-DESATURASE DES1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08557">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017228">
        <property type="entry name" value="Sphnglp_dlt4_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01269">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingolipid delta4-desaturase N-terminal" evidence="11">
        <location>
            <begin position="45"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ85724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="397" mass="44913" checksum="D816A27FA8457377" modified="2006-03-21" version="1">MARSVTATTNGASKRREPANGKANRQVNGSANGAAPEAEAQVDDASYRDFFWTYTEEPHRTRRLAIIKAHPEVTKLCGPEPLTKYVVAGVVGLQILLAHLLRDTSFWSWKFWAVAYVFGATSNQNLFLAIHEISHNLAFRSPMANRLFAIFANLPIAVPYSASFRPYHLTHHKSLGVDGLDTDLPTAFEAVFLDSILGKAFFCTFQIFFYALRPMTVYRVPFTWVHGLNVAVQLGFDYALACLLPGYFTFNSVLYLLLSSFLAGSLHPTAGHFIAEHYVYEKIMPEARQPSNNIPVPETFSYYGPLNLVTYNVGLHNEHHDFPAIPWTRLPVLREMAKEFYADLPQHRSWTYVLWRFIFDEEIGMRCRVKRKQGGRVVGGGTVKAKVADWKEDEIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYK5</accession>
    <name>Q2GYK5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224605.1">
        <property type="nucleotide sequence ID" value="XM_001224604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYK5"/>
    <dbReference type="GeneID" id="4394456"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06949"/>
    <dbReference type="HOGENOM" id="CLU_1049734_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYK5"/>
    <dbReference type="OrthoDB" id="10303963at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="265" mass="29008" checksum="582C954A45368787" modified="2006-03-21" version="1">MTLGATSHSRRAGLMPCCSRWGECLVPASVSSSRAPLMERQPRKAPTELYAHAVNPQQRSLRPITGAREHKTRRNRPPDPTAATGSMPPSITAAGAPKWPDPQIGAVPREWGSRPADVQQPVGVAWTLLVVQMWKCFDRGVPDPETLTRFQRRHRTNQPQMRQAPGLGPVFVGRQLGCREPMAPGALQFNNSRHWIRTELNKNGSKMSSNLPRSTRLQGLNGLHQTISPSSHIQSPPGVAASCVTSIKVVGLARFEPSSTHSPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYP4</accession>
    <name>Q2GYP4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_06910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224566.1">
        <property type="nucleotide sequence ID" value="XM_001224565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYP4"/>
    <dbReference type="GeneID" id="4394231"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06910"/>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_125_3_1"/>
    <dbReference type="InParanoid" id="Q2GYP4"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208729" evidence="2">
        <location>
            <begin position="30"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="4">
        <location>
            <begin position="54"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="3">
        <location>
            <begin position="373"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1188"/>
            <end position="1221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ85657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1221" mass="135992" checksum="B908F8CA3762F1A1" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYY9</accession>
    <name>Q2GYY9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Purine-cytosine permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_05257</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224471.1">
        <property type="nucleotide sequence ID" value="XM_001224470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYY9"/>
    <dbReference type="FunCoup" id="Q2GYY9">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="GeneID" id="4392102"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05257"/>
    <dbReference type="eggNOG" id="ENOG502QQ8Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026016_2_1_1"/>
    <dbReference type="InParanoid" id="Q2GYY9"/>
    <dbReference type="OMA" id="YERWAWV"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF8">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G03000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ88638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="55731" checksum="46702506FBF239F5" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYZ0</accession>
    <name>Q2GYZ0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_05256</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224470.1">
        <property type="nucleotide sequence ID" value="XM_001224469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYZ0"/>
    <dbReference type="STRING" id="306901.Q2GYZ0"/>
    <dbReference type="GeneID" id="4392553"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05256"/>
    <dbReference type="eggNOG" id="ENOG502RUYT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_997489_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYZ0"/>
    <dbReference type="OMA" id="GYWILIM"/>
    <dbReference type="OrthoDB" id="3172332at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ88637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="279" mass="31691" checksum="B26AF2D3D631C559" modified="2006-03-21" version="1">MEPNKVQRTIKFYTKVKTGCLTCKKRKVKCDEEKPRCRRCTASGRECDGYPQDRQTALTTVNASPESHAVLFASPAERRSFFYFQSRACKPLGGYFNSSFWGREVLQAAIHYPPVRHLVIAIGSAYEAFETGSLGQETEFTLRQCNQSIRQLTVLGRATNPPSTESTFCILTASLLFIYLASIRGNHAEAIQHVRSAAKLLQDFERSAALARKPGDAVRPASFSRRLWRKDSKKQWPGTENCVKRWRAAKTPWMFSHEPFPRQDIRKIETGPPSYAFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZ78</accession>
    <name>Q2GZ78_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224382.1">
        <property type="nucleotide sequence ID" value="XM_001224381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZ78"/>
    <dbReference type="STRING" id="306901.Q2GZ78"/>
    <dbReference type="GeneID" id="4392857"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05168"/>
    <dbReference type="eggNOG" id="ENOG502RS3D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_493463_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZ78"/>
    <dbReference type="OMA" id="DCECLDR"/>
    <dbReference type="OrthoDB" id="4580131at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="552" mass="60954" checksum="0A2481F15362B2EB" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZN3</accession>
    <name>Q2GZN3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_05013</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224227.1">
        <property type="nucleotide sequence ID" value="XM_001224226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZN3"/>
    <dbReference type="STRING" id="306901.Q2GZN3"/>
    <dbReference type="GeneID" id="4391660"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05013"/>
    <dbReference type="eggNOG" id="KOG3053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026793_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GZN3"/>
    <dbReference type="OMA" id="DFDLWPP"/>
    <dbReference type="OrthoDB" id="5817083at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46283">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="244"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="341"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ88394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="55667" checksum="5DCE4D4ABE548852" modified="2006-03-21" version="1">MATPSNGNTAHSIIPAPLTTNEQHICFICLCTDVDTPNAVWVDPCPCSLEAHEGCMLRYIGEMETTRRRSNKNPLACPACKVPFIIEEPYDRFLAIRDNLYRRYSRAAPAVLGSFVIGGGFAGAMWYGGTAVSIFVGRDSFIRWLEGGGRQRLPSTLIKLATLSAIGPGLLIFRWLPSLGTVLLLPFSVLYGATLVAQDNLPTWPPSPQWAMTLMPVVQLSYSYLLHDLFGPLERRLNRTLRGLPATEDEAQPEARLAPNRPAARHEEEADGVRGAWANLTRAVRGLFGDDVDDAADEPPAVDWQVQHHLEVRIGGGGGGDNGDDDDTDEEDIRDALGEADQQRRDVPQEPQPQPQQQQQQQQQQPPAAQQPAAQAAGNQNEEGGNGGGNGGVNAGAGENNNDPASFFGLIINSVVTSLLFPAISYGMGELIRAVVPKGWVSPSRSWRSRTPPGLLQQRWGRSLAGGCLFVVLRDALALYTKYRRVQVRMKRKIKNVERKGQAKTQGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0F2</accession>
    <name>Q2H0F2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_04744</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223958.1">
        <property type="nucleotide sequence ID" value="XM_001223957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0F2"/>
    <dbReference type="FunCoup" id="Q2H0F2">
        <property type="interactions" value="232"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H0F2"/>
    <dbReference type="GeneID" id="4392225"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04744"/>
    <dbReference type="eggNOG" id="KOG0873">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047036_5_0_1"/>
    <dbReference type="InParanoid" id="Q2H0F2"/>
    <dbReference type="OMA" id="KVHHKYA"/>
    <dbReference type="OrthoDB" id="1658724at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000254">
        <property type="term" value="F:C-4 methylsterol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="5">
        <location>
            <begin position="146"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ88125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="269" mass="31305" checksum="10E8ED5EBAD2539A" modified="2006-03-21" version="1">MASAVLNSTISGLSSSASITTVFEEVSKYNVQLNVFERLWASWYLWMQNDTIATGIMSFVMHEFVYFGRSLPWIIIDAIPFFNKYKLQNTKVPTWKEQWECAGLVLLSHCTVELPQIWLFHPIATYFGLDYGVPFPPAWKMAMQIAIFFAVEDAWHYWMHRALHYGPLYKSIHKLHHTYSAPFGLAAEYASPIEAIDAHSGYDFPWSLRRILPFWAGADHHDLHHERFIGNYASSFRWWDYCLDTEAGEAASKQRRERKLAEIRAKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0T8</accession>
    <name>Q2H0T8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_04608</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May be involved in the turnover of nuclear polyadenylated (pA+) RNA.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223822.1">
        <property type="nucleotide sequence ID" value="XM_001223821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0T8"/>
    <dbReference type="STRING" id="306901.Q2H0T8"/>
    <dbReference type="GeneID" id="4392112"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04608"/>
    <dbReference type="eggNOG" id="KOG2135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017928_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H0T8"/>
    <dbReference type="OMA" id="ITYDSHA"/>
    <dbReference type="OrthoDB" id="443401at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12257">
        <property type="entry name" value="RRM1_RBM26_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1390.10:FF:000007">
        <property type="entry name" value="CCCH zinc finger and RRM domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000647">
        <property type="entry name" value="CCCH zinc finger and RRM domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045137">
        <property type="entry name" value="RBM26/27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398">
        <property type="entry name" value="RNA RECOGNITION RRM/RNP DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN SWM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="364"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="130"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="316"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="440"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="527"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="575"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="712"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="527"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="712"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="751"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="772"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="812"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ87989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="823" mass="90564" checksum="67C425452DAA749C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0Z9</accession>
    <name>Q2H0Z9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_04547</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223761.1">
        <property type="nucleotide sequence ID" value="XM_001223760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0Z9"/>
    <dbReference type="FunCoup" id="Q2H0Z9">
        <property type="interactions" value="516"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H0Z9"/>
    <dbReference type="GeneID" id="4392575"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04547"/>
    <dbReference type="eggNOG" id="KOG1800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024722_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H0Z9"/>
    <dbReference type="OMA" id="NRPCAKE"/>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008860">
        <property type="term" value="F:ferredoxin-NAD+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055275">
        <property type="entry name" value="Ferredox_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="7">
        <location>
            <begin position="46"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="342"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ87928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="438" mass="47270" checksum="50F984C179951A6F" modified="2006-03-21" version="1">MLPLRYARWQPRAAWMRKLNASCLNPVTFRTLSTAQSARDDGRPFRLAVIGSGPAGFYTAYRAMSKIQNAKVDMYEALPVPFGLVRFGVAPDHPEVKNCQEKFEEVASSPNFTFIGNVSVGTKSDHPDGGTIPLASILRHYNAVVFSYGAAKDRTLGIPGEDLKGVYSAREFVGWYNGLPEHTDLAPDLTQGEEAVIIGQGNVALDVARMLLEDVNVLRKSDIAEHAIETLSKSKVKRVHIVGRRGPMQAAFTIKEIRELMRLPSVAFHPIDTSLIPPDPKSLPRAPRRLMDILLKGSPTTPSSEAAQKSWSLDFLLSPTAFLPTTTTPTTTPRLASTQFTHTTLSPTPFDPQAYALPSPPLNPPPTRHTNPPHPARLLAPSAIARRPSPSSLRSACPSGSGGGGSATPSTASRGMSGTRPTPPWSWGSFRACTVPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1F1</accession>
    <name>Q2H1F1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223609.1">
        <property type="nucleotide sequence ID" value="XM_001223608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1F1"/>
    <dbReference type="GeneID" id="4392165"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04395"/>
    <dbReference type="HOGENOM" id="CLU_1294248_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H1F1"/>
    <dbReference type="OrthoDB" id="10653066at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="213" mass="22935" checksum="347F46B6D20717EF" modified="2006-03-21" version="1">MFSSSPEGGIPTLNSFSGSPPVPTKSIIATGDTSTHRGDAIWETNGICRAQQTRRRSVEASMREARGRDEGEQDHSGPGSHHNPRSCVWGGSEDREWCTGSQISGPPPATGHSDCTRSTMGSHPRSTAGHVPVGWYGDQARSDPSRRVFSTRATQTRRSERRGQQEAETSGDAEGLAQVHLSFSAVTLSTAEEPAEIALNDLRDRLRDPAKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1I0</accession>
    <name>Q2H1I0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223580.1">
        <property type="nucleotide sequence ID" value="XM_001223579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1I0"/>
    <dbReference type="ESTHER" id="chagb-q2h1i0">
        <property type="family name" value="Hormone-sensitive_lipase_like"/>
    </dbReference>
    <dbReference type="GeneID" id="4392117"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04366"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_9_1_1"/>
    <dbReference type="InParanoid" id="Q2H1I0"/>
    <dbReference type="OMA" id="WIREGCE"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF339">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="56"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="422" mass="45955" checksum="DA5A85CE51AA9708" modified="2006-03-21" version="1">MADYPEIRAKVAADLQTRFDRVDVTYKTVNNVSLQTAIFVPKTISSLTEATAAPVLVHFHGGGLITGAALDLLFLVDWVRDLAHSTRTIFLSPHYRLAPETPAVHILDDIADFWAWVHSAHLPATLITHWPHLTADLTRLAAVGESAGGYLALQSALQMNQAARLRAVIAQYPGIFPDLAAFNPRPAEPDAGLDKVVEGYVSGLEAGVVRVSTAWPGFAEVTMAAMRNGLMRRLFGEDGKGRLTLGYALGKAEQVPPAMWVIQGTEDGLVAKGAADELVERVRRERPGAVVKYTVREGDHGFDAGSSLGDEWVAEGVEFVKGYWLKLAHQAIRARELFLLGGNRRRLQFGPSSALRNVRTVAEWEPTKDNNKTQVLWAFLKPLAGYGCKLAPENDTGGGSGSGGRHQMDTWQHNGPLQDLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1M7</accession>
    <name>Q2H1M7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-ornithine N(5)-oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_04319</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223533.1">
        <property type="nucleotide sequence ID" value="XM_001223532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1M7"/>
    <dbReference type="GeneID" id="4391836"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04319"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019225_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H1M7"/>
    <dbReference type="OMA" id="WISPFWI"/>
    <dbReference type="OrthoDB" id="2915840at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000258">
        <property type="entry name" value="Flavin-binding monooxygenase-like protein (AFU_orthologue AFUA_6G01900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="493"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ87700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="604" mass="68070" checksum="65B5886C6F910C64" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H238</accession>
    <name>Q2H238_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_04158</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223372.1">
        <property type="nucleotide sequence ID" value="XM_001223371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H238"/>
    <dbReference type="STRING" id="306901.Q2H238"/>
    <dbReference type="GeneID" id="4393059"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04158"/>
    <dbReference type="eggNOG" id="KOG0372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_0_5_1"/>
    <dbReference type="InParanoid" id="Q2H238"/>
    <dbReference type="OMA" id="QRGAGYT"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901525">
        <property type="term" value="P:negative regulation of mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="7">
        <location>
            <begin position="178"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ87539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="294" mass="33071" checksum="111CF7174F1CA240" modified="2006-03-21" version="1">MTPQRSVKAAGLAAVLRFLLLTDEKEPLAMLHSSRVLSTSTPQHRLRPECRAPPRSASQATSTDTSCAAASVDLDECISRLYKKELLAESVIEAICAKTKELLMRESNVVHVRAPVTVVGDIHGQFYDLIEIFKIGGWCPDTNYLFLGDYVDRGMFSVETISLLVCLKLRYPNRVHLIRGNHESRGVTQSYGFYTECSRKYGNANVWHYFTDMFDFLTLSVVINDQIFCVHGGLSPSIHSIDQIKIIDRFREIPHEGPMARPCSGPDPDPERDEFPLSLRRAGYSFGVQVVNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H286</accession>
    <name>Q2H286_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223324.1">
        <property type="nucleotide sequence ID" value="XM_001223323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H286"/>
    <dbReference type="GeneID" id="4391866"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04110"/>
    <dbReference type="eggNOG" id="ENOG502RHKW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_513992_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H286"/>
    <dbReference type="OMA" id="IRWVEAD"/>
    <dbReference type="OrthoDB" id="4770059at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="499" mass="52073" checksum="0E6F58FC0C9E5728" modified="2006-03-21" version="1">MGSMSAPTAAYGGTTPLAALTSVFTPPCPTSWLLTTTRSFSQYPPFPTTGPASCDPPSWRTNIAGAGFHYYSPAICPQGFVVGPNCGITKTRTDEGFPAIAPGETAVYCVPSGLTCTTDLTDFRGGVWGFASPAMTPGALATVGPAIQIRWVEADLTKLETHPLTPGLKLARTDSEKTSPPGMGSTTTTGPATGTTATPGKRPALEDGETETSTTVGPDTQGSPGSIGGFTHIFDPLDPTTSLAPANTAGSASDGGIGSLDRTTSIVVIVVVTVVAGIGLWVAAFLLVRRYKKRVAKRQGSRSTTYGDETSLEQGSHRHKRGESGVPQSMISPASELYAGPPAIGSTPNPAELEGDVVVQLPAKTWVHQKLWQKGSSLQPPLTSPRSMMSARSARRTVRESFGEKVNDPAAALGRLKIPTPRAMGRPSPSSASPGGRSFWRMQRSPRSPLAPGRLSAQLPKPSPRSRLSGNVSRASTPGRGKPGWQGDVSENTQRDATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2C2</accession>
    <name>Q2H2C2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223288.1">
        <property type="nucleotide sequence ID" value="XM_001223287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2C2"/>
    <dbReference type="GeneID" id="4392616"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04074"/>
    <dbReference type="eggNOG" id="ENOG502RR6X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_468505_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2C2"/>
    <dbReference type="OrthoDB" id="4578798at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="582" mass="64118" checksum="BE547189A14B13CE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H380</accession>
    <name>Q2H380_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_03766</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222980.1">
        <property type="nucleotide sequence ID" value="XM_001222979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H380"/>
    <dbReference type="STRING" id="306901.Q2H380"/>
    <dbReference type="GeneID" id="4392537"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03766"/>
    <dbReference type="eggNOG" id="ENOG502SASX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125562_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H380"/>
    <dbReference type="OMA" id="AATWFDF"/>
    <dbReference type="OrthoDB" id="2017497at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032126">
        <property type="term" value="C:eisosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052649">
        <property type="entry name" value="NCE102-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="6"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ87147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="186" mass="19556" checksum="D07E75FB873E0033" modified="2006-03-21" version="1">MLKPITLGLRGLYFVMALTILALAAAMIANQVYDTPPVTTRYSTFTGGFGMIVAGVGVLCTFVSFVPELVPLVLDGLAALFFLGGGIAWAYGLKDTSNCSNYETMLYSPLLNQGSIKFGDKTGYGVAAGEDATPESIMSALKGNCQRAQADEILQFLCFGLGTALVGLGFLQRRRGGGMHSGAYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3T5</accession>
    <name>Q2H3T5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cellobiose dehydrogenase-like cytochrome domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_06680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222775.1">
        <property type="nucleotide sequence ID" value="XM_001222774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3T5"/>
    <dbReference type="STRING" id="306901.Q2H3T5"/>
    <dbReference type="GeneID" id="4391462"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06680"/>
    <dbReference type="eggNOG" id="ENOG502SYC2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_725872_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3T5"/>
    <dbReference type="OrthoDB" id="413885at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF5">
        <property type="entry name" value="CELLOBIOSE DEHYDROGENASE CYTOCHROME DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209252" description="Cellobiose dehydrogenase-like cytochrome domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Cellobiose dehydrogenase-like cytochrome" evidence="3">
        <location>
            <begin position="36"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ90061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="353" mass="36394" checksum="AB58464B6D144ABB" modified="2006-03-21" version="1">MILKSLVLLAFGGTHTWAASIGGSGPGKRQSTTAKYCPGGTQICFSEFREPASGIYYRIAIPEVSAAPFDVLLQIVAPVDKAGWAGVAWGGKMNGNPLTVGWPNGDGAVVSSRWSTQWEGGSLDPNGVNSLAWAKNTRVVSSASSNTSSFAYHDGRGVFDHDLSVAKVPQGVFDAIVYALNNPTPPATDTASAVSTAVTTVAKPTTTSSRRTTPTRLTELPGPSSAPVKTASAVVTTGVTQLPKPTSTSIRGKPPIPHTSNSATRKPTTPSVVTITVTARPPMTTQNDDDDDNDGDDDDGWGEWPPWTSGGGPPWGGGKGKGKGGGGGGGGGWGRGGWRRGKRGRLIAPPGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H459</accession>
    <name>Q2H459_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_06556</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cytoplasmic vesicle</location>
            <location evidence="13">COPI-coated vesicle membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the COPG family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222651.1">
        <property type="nucleotide sequence ID" value="XM_001222650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H459"/>
    <dbReference type="FunCoup" id="Q2H459">
        <property type="interactions" value="1107"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H459"/>
    <dbReference type="GeneID" id="4390863"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06556"/>
    <dbReference type="eggNOG" id="KOG1078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010353_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H459"/>
    <dbReference type="OMA" id="DFIEDCE"/>
    <dbReference type="OrthoDB" id="1074925at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000046">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000071">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1480:FF:000001">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000008">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1480">
        <property type="entry name" value="Coatomer, gamma subunit, appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032154">
        <property type="entry name" value="Coatomer_g_Cpla"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017106">
        <property type="entry name" value="Coatomer_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013040">
        <property type="entry name" value="Coatomer_gsu_app_Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037067">
        <property type="entry name" value="Coatomer_gsu_app_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261:SF0">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16381">
        <property type="entry name" value="Coatomer_g_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08752">
        <property type="entry name" value="COP-gamma_platf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037093">
        <property type="entry name" value="Coatomer_gamma_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="15">
        <location>
            <begin position="21"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer gamma subunit appendage Ig-like subdomain" evidence="16">
        <location>
            <begin position="651"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer subunit gamma C-terminal" evidence="17">
        <location>
            <begin position="802"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="609"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR037093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ89937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="917" mass="101231" checksum="31B70E5F62BBA1FF" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4G2</accession>
    <name>Q2H4G2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="7">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_06453</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <text evidence="6">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.</text>
    </comment>
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        <reaction evidence="1 7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
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    <dbReference type="eggNOG" id="KOG0169">
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    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF82">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
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        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ89834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
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        </source>
    </evidence>
    <sequence length="693" mass="78663" checksum="837ED2C522650C67" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4K3</accession>
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    </protein>
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    <organism evidence="2 3">
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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        </lineage>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
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            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        </location>
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            <end position="232"/>
        </location>
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        <location>
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            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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            <end position="294"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="64174" checksum="44B0F01799D0277E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4Q0</accession>
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        <recommendedName>
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ89746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_001222459.1"/>
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    <dbReference type="AlphaFoldDB" id="Q2H4Q0"/>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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            <begin position="1"/>
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        </location>
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        </location>
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        </location>
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        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ89746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="53230" checksum="615906CE2C4450C5" modified="2006-03-21" version="1">MSNSSPNTNPISKPTSHPSDDHDPNSRRASHAILAAQGIDPLDVADPADDNWDRDPARLHTHTPTQKTPTPTQTPTRKRGWGQTEVRTGTVSTTTPTTTPPHSPRRREESLYPEFTTQGPSLRFLKAQGVDPLDVAEDEDWEGRGGKKRKVGGGWGPGVKKEEEKKKDGAVGGGDDDEEEVEEEEDEEEDEDARGEEPEESEFERRERELEFPPSRLDYWEPMDDYTRDVRRRCTVAGDEPHRPRGAPEYATWFGEKREEAERFQELKLAMDGYFYGIKPPFARCALCADAQLSLRFVPIYIPRDAKDREDMPDLERGAVLICGHMVCRPCWERVVELHNKEAEADAEALERRGAYPPLHCPVCRVELCHPRCECHIAAHRMPRSLEDPQASQYYCSHWGNYYSYLDDGWMEEMPPVLHNSHIHGNFDAVIPNRCDECIANPRHKWDAGIQVPRAFKLGDLRPGYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H539</accession>
    <name>Q2H539_CHAGB</name>
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        <recommendedName>
            <fullName evidence="10">Lipoyl synthase, mitochondrial</fullName>
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        <alternativeName>
            <fullName evidence="10">Lipoate synthase</fullName>
            <shortName evidence="10">LS</shortName>
            <shortName evidence="10">Lip-syn</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Lipoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_06226</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="10"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222321.1">
        <property type="nucleotide sequence ID" value="XM_001222320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H539"/>
    <dbReference type="FunCoup" id="Q2H539">
        <property type="interactions" value="507"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H539"/>
    <dbReference type="GeneID" id="4390403"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06226"/>
    <dbReference type="eggNOG" id="KOG2672">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033144_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H539"/>
    <dbReference type="OMA" id="PYCDIDF"/>
    <dbReference type="OrthoDB" id="3231at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000036">
        <property type="entry name" value="Lipoyl synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="114"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ89607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="388" mass="43089" checksum="E9F3434D6923AD0B" modified="2006-03-21" version="1">MIFHHVDQQRREQRRQGPPRRHRGEHVASLKNFLPTATPNTLPPSEAYAPRTATVGPEGRKRTITRLPEWLKTPIPSAGTNAGFAKIKADLRGLGLHTVCEEARCPNIGECWGGGSKAAATATIMLMGDTCTRGCRFCSVKTSRAPPPLDPHEPENTAEALARWGLGYVVLTSVDRDDLADGGARHFAETIRRIKAKKPTMLVEALTGDFWGNLEMVKVVAESGLDVYAHNVETVEGLTPYVRDRRATFRQSLKVLEHVKEVKGKEGIITKTSIMLGLGETEEEIWETLRELRKVDVDVVTFGQYMRPTKRHLQVERYVTPDEFELWRQRALDMGFLYCASGPLVRSSYKAGEAFIENVLRKRAGEKAMATDSLGQAVAAEEATGKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H564</accession>
    <name>Q2H564_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CHGG_06201</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222296.1">
        <property type="nucleotide sequence ID" value="XM_001222295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H564"/>
    <dbReference type="STRING" id="306901.Q2H564"/>
    <dbReference type="GeneID" id="4390384"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06201"/>
    <dbReference type="eggNOG" id="ENOG502S2Z9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101422_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H564"/>
    <dbReference type="OMA" id="ACQCASD"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208965" description="CFEM domain-containing protein" evidence="17">
        <location>
            <begin position="17"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="94"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAQ89582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="194" mass="18073" checksum="3391BB7B95728720" modified="2006-03-21" version="1">MKAILLLLAATGIALAQNLSGQPDCATACIISAISAAGCGASDLGCQCGPTQSFIAASAAPCLLSSCTGTQLIQAQSAGAAQCSSYSATAASNSATTTPATRNGMASSTSGAAATPAEGSETSASASAPASTSGSAGLNDSSSTSTGAAAAMATPAIMGAGALLGAIGAAVALGLRISVHHDSVPAHLSSLPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5G4</accession>
    <name>Q2H5G4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADPH-dependent FMN reductase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222196.1">
        <property type="nucleotide sequence ID" value="XM_001222195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5G4"/>
    <dbReference type="GeneID" id="4390740"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06101"/>
    <dbReference type="eggNOG" id="ENOG502QQY8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055322_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H5G4"/>
    <dbReference type="OMA" id="RPMPTHR"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014063">
        <property type="entry name" value="Arsenate-R_ArsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02690">
        <property type="entry name" value="resist_ArsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43590">
        <property type="entry name" value="ARSENIC RESISTANCE PROTEIN ARSH (AFU_ORTHOLOGUE AFUA_5G15030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43590:SF1">
        <property type="entry name" value="ARSENIC RESISTANCE PROTEIN ARSH (AFU_ORTHOLOGUE AFUA_5G15030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="199" mass="22622" checksum="22F3EAFFA97C67A3" modified="2006-03-21" version="1">MSTLRSYSKLLAYEASRILFRLGCDVRVYDPSGLPVKDDQQHDHPKVQELRELSKWSDGHIWVSPEQHGALTGVFKNQIDWIPLSTGSVRPTQGRTLAIAQVNGGSQSFNAVNSLRILGRWMRMFTIPNQSSIPQAWTHFTDADDPVDGGNRLKASSNRNRLVDCMEEFVKYTIVMRPHFDLFGDRFSEREEAKAKTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6F9</accession>
    <name>Q2H6F9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_05756</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221851.1">
        <property type="nucleotide sequence ID" value="XM_001221850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6F9"/>
    <dbReference type="FunCoup" id="Q2H6F9">
        <property type="interactions" value="111"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H6F9"/>
    <dbReference type="GeneID" id="4391057"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05756"/>
    <dbReference type="eggNOG" id="KOG0955">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002663_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6F9"/>
    <dbReference type="OMA" id="NTSKWSH"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15670">
        <property type="entry name" value="ePHD_BRPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15492">
        <property type="entry name" value="PHD_BRPF_JADE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000008">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000007">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="386"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="440"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="131"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="352"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="826"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="891"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="924"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ89137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="944" mass="104943" checksum="A896F97057BA9060" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6H2</accession>
    <name>Q2H6H2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_05743</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221838.1">
        <property type="nucleotide sequence ID" value="XM_001221837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6H2"/>
    <dbReference type="STRING" id="306901.Q2H6H2"/>
    <dbReference type="GeneID" id="4390312"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05743"/>
    <dbReference type="eggNOG" id="KOG0380">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018190_3_0_1"/>
    <dbReference type="InParanoid" id="Q2H6H2"/>
    <dbReference type="OMA" id="RCHDYRR"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF7">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="440"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="502"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ89124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="551" mass="62032" checksum="566D496CEB8349E0" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6V2</accession>
    <name>Q2H6V2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221708.1">
        <property type="nucleotide sequence ID" value="XM_001221707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6V2"/>
    <dbReference type="STRING" id="306901.Q2H6V2"/>
    <dbReference type="GeneID" id="4390515"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05613"/>
    <dbReference type="eggNOG" id="KOG0031">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2072864_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6V2"/>
    <dbReference type="OMA" id="NEGDAHV"/>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="118" mass="12356" checksum="46533875A0F82211" modified="2006-03-21" version="1">MPMALFLNSIANSLVALSPGPELLSAFSAFDDDDSGQIDVAELRDALLHTAPEPGQEPLTALDVEKVIAGFTGRRAFSKSSATGLGKRGEVFRYQDFVNTVSGGNGAAARADDDAEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H798</accession>
    <name>Q2H798_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221562.1">
        <property type="nucleotide sequence ID" value="XM_001221561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H798"/>
    <dbReference type="GeneID" id="4391041"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05467"/>
    <dbReference type="HOGENOM" id="CLU_2096595_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H798"/>
    <dbReference type="OrthoDB" id="10302654at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="116" mass="12679" checksum="DEB1B38B516FC5FD" modified="2006-03-21" version="1">MAAPTRHDAAAAVTFLVSGMAREDCVYPPYPYQDQLHEIDLVPLPLPAQAAGVEETRGRDSWRDDAYTAMLGMSADLATPPKREAGQGQYSDVDTRSVEVSLDEEDLARRGVELKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7A6</accession>
    <name>Q2H7A6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_05459</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221554.1">
        <property type="nucleotide sequence ID" value="XM_001221553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7A6"/>
    <dbReference type="STRING" id="306901.Q2H7A6"/>
    <dbReference type="GeneID" id="4391027"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05459"/>
    <dbReference type="eggNOG" id="KOG0743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010189_4_3_1"/>
    <dbReference type="InParanoid" id="Q2H7A6"/>
    <dbReference type="OMA" id="AKGMFER"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
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            <end position="254"/>
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        </location>
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        </location>
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            <end position="383"/>
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        </location>
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    </feature>
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        <source>
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    </evidence>
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        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SMART" id="SM00382"/>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="664" mass="75635" checksum="24DEB9FFDE5DAA30" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7H0</accession>
    <name>Q2H7H0_CHAGB</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">CHGG_05395</name>
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        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="235" mass="25829" checksum="25AADDD0FF9A0E02" modified="2006-03-21" version="1">MAVTETQIMGRGSGARSTIRTQRQCERARGVAKFTVQVELTRVEMVQPHPCMALAFQGVPNPCLTPHRDHHNRKPRDWLCCSLPCRKGIPVRTCCAQTAQHWKAEISSLVAKRPGPEYGREPAACTNASLSSRREVQLEPTAPDRMPLLGWLGRIRLALTEPAQDQAAANNMIKGFLAAVDAATRSSSSRLRLPRRRRRVEVRDAGSAIGFPSLGGTQHAAREGKGSSRASMERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7W3</accession>
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        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="9" type="ORF">CHGG_03691</name>
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        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001230206.1"/>
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    <dbReference type="STRING" id="306901.Q2H7W3"/>
    <dbReference type="GeneID" id="4389903"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03691"/>
    <dbReference type="eggNOG" id="ENOG502SKXY">
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    <dbReference type="InParanoid" id="Q2H7W3"/>
    <dbReference type="OMA" id="CSHHNIP"/>
    <dbReference type="OrthoDB" id="4116913at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="5"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ91756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="608" mass="68163" checksum="FED73418B122448D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H894</accession>
    <name>Q2H894_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230076.1">
        <property type="nucleotide sequence ID" value="XM_001230075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H894"/>
    <dbReference type="GeneID" id="4388762"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03560"/>
    <dbReference type="eggNOG" id="ENOG502SYJR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_440041_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H894"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="502"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="621" mass="71318" checksum="7663C6D506FBE945" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8A0</accession>
    <name>Q2H8A0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation elongation factor IF5A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230070.1">
        <property type="nucleotide sequence ID" value="XM_001230069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8A0"/>
    <dbReference type="STRING" id="306901.Q2H8A0"/>
    <dbReference type="GeneID" id="4388382"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03554"/>
    <dbReference type="eggNOG" id="KOG3271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021655_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H8A0"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="22193" checksum="F3E525F15DE44B36" modified="2006-03-21" version="1">MSRPRVGGSRYPSWFFGRSQSLRNPQSDEKTPLTSPATPNTIPIPCHDIRLGDILMLKDSPCRVIQILTSAATGRYTYRGVDILTEYIHEATSFVSNPSPNVAVQTMLRPRLFQYHAVVITQNSLTCMNETGDVVVENMRVMDGSGLWTRLATACEWDIDTVRVLAVHFQNHKIGVDMKIVQRSRRFGDRPATAGTASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8D8</accession>
    <name>Q2H8D8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_03516</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230032.1">
        <property type="nucleotide sequence ID" value="XM_001230031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8D8"/>
    <dbReference type="FunCoup" id="Q2H8D8">
        <property type="interactions" value="877"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H8D8"/>
    <dbReference type="GeneID" id="4388643"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03516"/>
    <dbReference type="eggNOG" id="KOG3259">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090028_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8D8"/>
    <dbReference type="OMA" id="DEVQCLH"/>
    <dbReference type="OrthoDB" id="2530521at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140463">
        <property type="term" value="F:chromatin-protein adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000066">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000026">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="7">
        <location>
            <begin position="70"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ91581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="181" mass="20334" checksum="65FB97C0469D077E" modified="2006-03-21" version="1">MTDQSETGLPPNWEVRHSNSKNLPYYFNSVEKVSRWEPPAETDTEKLKLYMAEYHSNKGLAAGTGEDRQPGKIRAAHLLVKHRDSRRPSSWRENTITRTKEDAYEIIKAHEARIKGGEVSLGQLALTESDCSSARKQGDLGFFGRGDMQKEFEDAAFALREGEVSGIVDTASGLHLIERLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8P0</accession>
    <name>Q2H8P0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin kinase</fullName>
            <ecNumber evidence="4">2.7.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Flavin mononucleotide kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_03414</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>riboflavin + ATP = FMN + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="4"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229930.1">
        <property type="nucleotide sequence ID" value="XM_001229929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8P0"/>
    <dbReference type="STRING" id="306901.Q2H8P0"/>
    <dbReference type="GeneID" id="4389768"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03414"/>
    <dbReference type="eggNOG" id="KOG3110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022880_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8P0"/>
    <dbReference type="OrthoDB" id="276388at2759"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749:SF6">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Riboflavin kinase" evidence="15">
        <location>
            <begin position="470"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="94"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAQ91479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="690" mass="74839" checksum="B04E352E3B348920" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H926</accession>
    <name>Q2H926_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229794.1">
        <property type="nucleotide sequence ID" value="XM_001229793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H926"/>
    <dbReference type="GeneID" id="4389318"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03278"/>
    <dbReference type="eggNOG" id="ENOG502SAQG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089389_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H926"/>
    <dbReference type="OMA" id="DRMGGLK"/>
    <dbReference type="OrthoDB" id="5388417at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="178" mass="20155" checksum="8296CE622E32AAB8" modified="2006-03-21" version="1">MDSFTRIVARGDEEKDNNKTVNILIALLVLVFVGLVAFALLVLLRRKRRQRQMMNETLPQYHDVKRTGNHRRLTIQTGNGRSSVIVVDNNGQPMLANPQSPPHSPDNVPEIHITFPDEQDDQGRPKSGRVVVVRVGETSVGLEPLDDEQLPAYEKESKTQFYSIDMDKIGGLKEKEFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9Q8</accession>
    <name>Q2H9Q8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_03046</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TACO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229562.1">
        <property type="nucleotide sequence ID" value="XM_001229561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9Q8"/>
    <dbReference type="FunCoup" id="Q2H9Q8">
        <property type="interactions" value="262"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H9Q8"/>
    <dbReference type="GeneID" id="4389604"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03046"/>
    <dbReference type="eggNOG" id="KOG2972">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062974_1_2_1"/>
    <dbReference type="InParanoid" id="Q2H9Q8"/>
    <dbReference type="OMA" id="NFDIPDE"/>
    <dbReference type="OrthoDB" id="2017544at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.200:FF:000002">
        <property type="entry name" value="Probable transcriptional regulatory protein CLM62_37755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048300">
        <property type="entry name" value="TACO1_YebC-like_2nd/3rd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049083">
        <property type="entry name" value="TACO1_YebC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532:SF0">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20772">
        <property type="entry name" value="TACO1_YebC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="YebC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TACO1/YebC-like N-terminal" evidence="4">
        <location>
            <begin position="40"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="TACO1/YebC-like second and third" evidence="3">
        <location>
            <begin position="119"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ91111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="32185" checksum="04BC598283875B96" modified="2006-03-21" version="1">MTTLLRPLAPLTRSAIPSPSICAQCRRTFVSSPALRSGHNKWSKIRHDKAANDAKKNATRTIFAKNITLYSKLFGPDPNNNPQLAAAINAAKKASVPKDKIEGAIARGQGKSSGGAALDSITFEAMMPPSIALIVDLETESKLRALQDLNQMVKKAKGSTSSSKFFFSRLGRVVFEKGENGLDVDQIMDDAIEAGAEDLENDADGNIIVWTQPSATMQVCKTVGSKFGLKILSSDIIWTANEDTKAELDASEELKSFTDLLEALREYPEVQAVYSNVSKGSMSDEEWARIEENLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HA73</accession>
    <name>Q2HA73_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Thiamine phosphate synthase/TenI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CHGG_02881</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-methyl-5-(2-phosphooxyethyl)-thiazole + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H(+) = thiamine phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the C-terminal section; belongs to the Thz kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">In the N-terminal section; belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229397.1">
        <property type="nucleotide sequence ID" value="XM_001229396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HA73"/>
    <dbReference type="FunCoup" id="Q2HA73">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HA73"/>
    <dbReference type="GeneID" id="4389218"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02881"/>
    <dbReference type="eggNOG" id="ENOG502QS2M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019943_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HA73"/>
    <dbReference type="OMA" id="GQTDMPI"/>
    <dbReference type="OrthoDB" id="4994at2759"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004417">
        <property type="term" value="F:hydroxyethylthiazole kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01170">
        <property type="entry name" value="THZ_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000104">
        <property type="entry name" value="Thiamine biosynthetic bifunctional enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000417">
        <property type="entry name" value="Hyethyz_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857:SF23">
        <property type="entry name" value="THIAMINE BIOSYNTHETIC BIFUNCTIONAL ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857">
        <property type="entry name" value="THIAMINE-PHOSPHATE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02110">
        <property type="entry name" value="HK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01099">
        <property type="entry name" value="HYETHTZKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="Thiamin phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamine phosphate synthase/TenI" evidence="18">
        <location>
            <begin position="10"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00061283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAQ90946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="484" mass="51167" checksum="7D7E4259CCC33378" modified="2006-03-21" version="1">MGKPEVDYGLYLVTDSTPAILGDRNLNEVVEASLKGGVTIVQLREKKGDTAELIAKAKALHEITKRYNVPLLINDRVDVALAVDCEGIHIGQDDMDLSTARKLLGPDKIIGVTASTVDEALKACEGGADYLGIGTVYATPTKTNTKEIIGAAGVREILGKIADAGHKTQTVCIGGVNESNLQRIVFQCAAAYKRLDGVAIVSAIMAAQDPESAAKKLLALVRSPPAFQADTRGKDSDVADVKTVVDLAPSVLQRVHETTPLSHNMTNIVVQNIAANVALAIGASPIMAGYGEEAPDLCKLGGALVINMGSVDPNGLTNYLKALKAYNLEGRPVVFDPVGQEQQRGVDSSSTLDASQKAQLVRELAAREKNVVVMTGKTDFVSDGVRTFAIDNGHEYLGMVTGTGCTLGTTISAAIASRTTNRLVAVIAAILHFEIAAEIAASRPEVRGPGSFVPAFLDELYLIRQATASKELSWLERAKVRSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HB86</accession>
    <name>Q2HB86_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_02518</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229034.1">
        <property type="nucleotide sequence ID" value="XM_001229033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HB86"/>
    <dbReference type="PeroxiBase" id="5357">
        <property type="entry name" value="CgAPx-CcP02"/>
    </dbReference>
    <dbReference type="GeneID" id="4389266"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02518"/>
    <dbReference type="eggNOG" id="KOG4157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004824_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HB86"/>
    <dbReference type="OMA" id="HDMSTAN"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000020">
        <property type="entry name" value="Peroxisomal ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051589">
        <property type="entry name" value="Sialate-O-sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964:SF5">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209159" evidence="4">
        <location>
            <begin position="22"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="5">
        <location>
            <begin position="124"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="6">
        <location>
            <begin position="590"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="6">
        <location>
            <begin position="704"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="6">
        <location>
            <begin position="834"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="6">
        <location>
            <begin position="961"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="549"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="802"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ90583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1053" mass="109783" checksum="6A3C7D18575BE6E2" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBB4</accession>
    <name>Q2HBB4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_02490</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229006.1">
        <property type="nucleotide sequence ID" value="XM_001229005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBB4"/>
    <dbReference type="STRING" id="306901.Q2HBB4"/>
    <dbReference type="GeneID" id="4389353"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02490"/>
    <dbReference type="eggNOG" id="KOG4344">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010106_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HBB4"/>
    <dbReference type="OMA" id="RTNQFEV"/>
    <dbReference type="OrthoDB" id="66546at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22572">
        <property type="entry name" value="GCP5_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059169">
        <property type="entry name" value="GCP5_N_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032797">
        <property type="entry name" value="Mod21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF33">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14609">
        <property type="entry name" value="GCP5-Mod21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-Tubulin ring complex non-core subunit mod21 N-terminal" evidence="8">
        <location>
            <begin position="61"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="226"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="536"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="767"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ90555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="888" mass="99930" checksum="8185B7F85E721864" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBE8</accession>
    <name>Q2HBE8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_02456</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ORC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228972.1">
        <property type="nucleotide sequence ID" value="XM_001228971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBE8"/>
    <dbReference type="FunCoup" id="Q2HBE8">
        <property type="interactions" value="861"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HBE8"/>
    <dbReference type="GeneID" id="4388757"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02456"/>
    <dbReference type="eggNOG" id="KOG2928">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018596_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HBE8"/>
    <dbReference type="OMA" id="AHERYFF"/>
    <dbReference type="OrthoDB" id="346673at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="7">
        <location>
            <begin position="252"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="8">
        <location>
            <begin position="500"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="155"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ90521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="547" mass="59574" checksum="E6AB0BAAD3C29EC7" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBF9</accession>
    <name>Q2HBF9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative gamma-glutamylcyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_02445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228961.1">
        <property type="nucleotide sequence ID" value="XM_001228960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBF9"/>
    <dbReference type="GeneID" id="4388920"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02445"/>
    <dbReference type="eggNOG" id="ENOG502S7T1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093936_1_2_1"/>
    <dbReference type="InParanoid" id="Q2HBF9"/>
    <dbReference type="OMA" id="DPEPWQK"/>
    <dbReference type="OrthoDB" id="1044435at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045038">
        <property type="entry name" value="AIG2-like"/>
    </dbReference>
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    <dbReference type="PANTHER" id="PTHR31544:SF2">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="26"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ90510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="167" mass="19068" checksum="73B50A6D9D125AAF" modified="2006-03-21" version="1">MATSDNDAQTSTQASMPSDDGTHCAFFYGTLMAADVFHTVCYGTKDVPEEISNLHTSHPAVLHGFCRRRVKYADYPGIIEDKDHNVVGTFVTGLTNANMARLDHFEGSQYERRPVTVSLLKKLTNGKLGEGTKVEAETYIFLNKRDLESREWDLEEFRREKMQRWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HC22</accession>
    <name>Q2HC22_CHAGB</name>
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        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">CHGG_02232</name>
    </gene>
    <organism evidence="7 8">
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001228747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HC22"/>
    <dbReference type="FunCoup" id="Q2HC22">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="GeneID" id="4388981"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02232"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_0_1"/>
    <dbReference type="InParanoid" id="Q2HC22"/>
    <dbReference type="OMA" id="LVQCTIG"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF20">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="448"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="510"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="72"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ90297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="555" mass="61614" checksum="A8CE14F204C15E3F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HC61</accession>
    <name>Q2HC61_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_02193</name>
    </gene>
    <organism evidence="10 11">
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228709.1">
        <property type="nucleotide sequence ID" value="XM_001228708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HC61"/>
    <dbReference type="GeneID" id="4389479"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02193"/>
    <dbReference type="eggNOG" id="ENOG502SJG4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_363688_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HC61"/>
    <dbReference type="OMA" id="MCTLHRK"/>
    <dbReference type="OrthoDB" id="762982at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="714"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="9">
        <location>
            <begin position="246"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ90258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="768" mass="84442" checksum="81756B06258AD53C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCP7</accession>
    <name>Q2HCP7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_02007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221228.1">
        <property type="nucleotide sequence ID" value="XM_001221227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCP7"/>
    <dbReference type="GeneID" id="4388212"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02007"/>
    <dbReference type="eggNOG" id="ENOG502T97K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_776123_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCP7"/>
    <dbReference type="OMA" id="RYFFHAR"/>
    <dbReference type="OrthoDB" id="10654578at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209206" evidence="2">
        <location>
            <begin position="21"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="357" mass="33751" checksum="01F362F4D63AE7E3" modified="2006-03-21" version="1">MSPLSWRQAVVASLLFGAQAAHIQPRQLTLPVGAGQNQNPLAELQTLIQGLLANLNLGGAAGAGAGAGAGAGAGIVVSTTTAAAANPAETAEAAPPPPPPPAAVPIANGTAGGNGTDVGRGKGKGNGRGKNNANNGNGNGNGNGNGNGNGRGKGKGKNADAAAGAGAAGLNLQDLLGLLTGGAGGGAGAGAGAGGGAGAGGLNLQDLLGLLTGGQQGGAGGGGGAGGLNLQDLLGLLTGGQQGNGNGNGNGNGNGNNAAATRASLEAMLQRVTEAQRKQQEQVQAQAQQGQQGQGEGQGRGKGKGKAVGDDGNDSDNEDGNDSDGDNSDDEGAGAGAGRRVVVPGRLRRRMRMGLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCU3</accession>
    <name>Q2HCU3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tetrahydrofolate synthase</fullName>
            <ecNumber evidence="3">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_01961</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="3"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221182.1">
        <property type="nucleotide sequence ID" value="XM_001221181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCU3"/>
    <dbReference type="STRING" id="306901.Q2HCU3"/>
    <dbReference type="GeneID" id="4388137"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01961"/>
    <dbReference type="eggNOG" id="KOG2525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015869_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HCU3"/>
    <dbReference type="OMA" id="HIHIAGT"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ93726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="456" mass="48683" checksum="12096A0A80E09DDD" modified="2006-03-21" version="1">MASPPPPPGEAAGGSYATALTRLAQLQSNRAITSLFDPPPTTTGPAQGKPIDINALAIPEMLAWLSRAGLPPSTLAASPLRCVHVAGTKGKGSVSALVAGVLGQYSPQVSSSSGGGDVDGDGGGGGVGLYTSPHVLSVRERIVLEGAPIAREKLGREVVTAAVVTQLGIDHVSMLGDTVEKIAWHKSGVFKEGVKAFTRKLPEEQAAVMEVLRARAREKGAVLVEVTDEEVERWGGVEGARLQGPFQKYNMALAVYAAREHLLQTGVKFEGRFGTDEWSLNDIPPEFVKGLKEAALRGRCEILKGEDGIEWHVDGAHTDDSLAGVGRWFGARTSGDEIRILVFNQQERDPTPLLRALLAGVKGATTFTHAIFTRNKEQKPESEDRDLSTQIRAQETMREVDSTTESTVQNAVEPTIEQVKSIAAQARKDGKACKVLVTGSFYLVGAVLKLIDHVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCU4</accession>
    <name>Q2HCU4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_01960</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 13">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221181.1">
        <property type="nucleotide sequence ID" value="XM_001221180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCU4"/>
    <dbReference type="FunCoup" id="Q2HCU4">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HCU4"/>
    <dbReference type="GeneID" id="4387751"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01960"/>
    <dbReference type="eggNOG" id="KOG1854">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008024_1_2_1"/>
    <dbReference type="InParanoid" id="Q2HCU4"/>
    <dbReference type="OMA" id="RLDHQMQ"/>
    <dbReference type="OrthoDB" id="10261039at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="41"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="197"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ93725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="670" mass="73692" checksum="39009F306E3606C9" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDE4</accession>
    <name>Q2HDE4_CHAGB</name>
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        <recommendedName>
            <fullName evidence="4">Rhodopsin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220981.1">
        <property type="nucleotide sequence ID" value="XM_001220980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDE4"/>
    <dbReference type="FunCoup" id="Q2HDE4">
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    </dbReference>
    <dbReference type="STRING" id="306901.Q2HDE4"/>
    <dbReference type="GeneID" id="4386897"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01760"/>
    <dbReference type="eggNOG" id="ENOG502S3KC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115926_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HDE4"/>
    <dbReference type="OMA" id="QNCGNFS"/>
    <dbReference type="OrthoDB" id="5545479at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139:SF1">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="12921" checksum="9A4582791BB1085C" modified="2006-03-21" version="1">MCIVFTCGEHTFRKEVEGYNGLVCRCYNCGNYSGSVVKSNPWFTFCFIPVIPLSMKGYEDVSCRICNFQQPLTHRPDVQALKGQGGQGVPMQSPPPGPQQGWNQGTPKPNEPMRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDG0</accession>
    <name>Q2HDG0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220965.1">
        <property type="nucleotide sequence ID" value="XM_001220964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDG0"/>
    <dbReference type="GeneID" id="4386776"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01744"/>
    <dbReference type="HOGENOM" id="CLU_1042072_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HDG0"/>
    <dbReference type="OrthoDB" id="10641021at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209140" evidence="2">
        <location>
            <begin position="21"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="267" mass="27062" checksum="7AE28743A2297E21" modified="2006-03-21" version="1">MRPHLVSVLLFISTGKLATAAPALTNNHHPLLNSPLFNTPLPPPPFPLGRVFPRLFRPPQALKLDAADLDTRSHHHQPLENPKQHGPLGAITVTDNAPLTLTPVSTLPLPDAETTPSTTEAPNPATDSSTASSNNNTSDPTPGSVIIIPANTISMLPPGPSPMPTITTTTLPASTPTTNNTDTDTDTTTALPAVIAQSVTFLETVAFTTTVLPAVTVTGLLTLTSVVVVSGTPVGGAVAFTTVVGVATGGGGDAVATAAAAAVVVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDY5</accession>
    <name>Q2HDY5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoinositide 5-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_01569</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptojanin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="4"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220790.1">
        <property type="nucleotide sequence ID" value="XM_001220789.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2HDY5">
        <property type="interactions" value="327"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HDY5"/>
    <dbReference type="GeneID" id="4387531"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01569"/>
    <dbReference type="eggNOG" id="KOG0566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003016_2_1_1"/>
    <dbReference type="InParanoid" id="Q2HDY5"/>
    <dbReference type="OMA" id="HPCHELR"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000029">
        <property type="entry name" value="Inositol polyphosphate 5-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF257">
        <property type="entry name" value="PHOSPHOINOSITIDE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SAC" evidence="10">
        <location>
            <begin position="191"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="976"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1247"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1014"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1039"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1072"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1135"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1158"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1190"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1218"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1278"/>
            <end position="1288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ93334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1313" mass="144153" checksum="9D0C3F6FA1FC3563" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEY8</accession>
    <name>Q2HEY8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_01216</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220437.1">
        <property type="nucleotide sequence ID" value="XM_001220436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEY8"/>
    <dbReference type="GeneID" id="4387675"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01216"/>
    <dbReference type="eggNOG" id="ENOG502QTGV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024810_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HEY8"/>
    <dbReference type="OMA" id="LYAYYIP"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ92981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="461" mass="49917" checksum="5CDD09B0F739A024" modified="2006-03-21" version="1">MDGLRTVPRESSMNLTDEERATLQHVERLGAALSLVGVCLIFITYGFFPRVRTVPNTFIFFASIANVGASIACLIGYSGILAGDSSALCQGQAFLLEIVIYVAVGYHVFHHRNQLRNLTLSNQARDAYCAERKESEKEQQSYGTVTTEVRVTAESSGSPTPPSTPAGSIAPVLNRPSTAAANAPWGQPHDDDNYDVNAHPTAFTTRGRGSSRGHTHSTTTHAGINPHHPTPFTTTLTISSSHPPKPPKRPHTSLPTRLARTWRKFQRKLATLDPIKLAYLRTSFVFALSILVTWTPSSINRVYSLAYPTRTSYGLNLASAVVLPLQGLWNATIFAAASWHILREEWLEARRRGRGCGGFWCAGVRGGARRLSSGAGGHVGGLGGGGGGVGGGGYEERGGQVALSLSGQGFRSRDGGLPEGRELTTMPRVANGRKRRRWILPREGPYTQEMDDQLLGAFQCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFU9</accession>
    <name>Q2HFU9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_00905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220126.1">
        <property type="nucleotide sequence ID" value="XM_001220125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFU9"/>
    <dbReference type="FunCoup" id="Q2HFU9">
        <property type="interactions" value="577"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HFU9"/>
    <dbReference type="GeneID" id="4386357"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00905"/>
    <dbReference type="eggNOG" id="KOG1379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029404_7_2_1"/>
    <dbReference type="InParanoid" id="Q2HFU9"/>
    <dbReference type="OMA" id="AYSEPQT"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13672">
        <property type="entry name" value="PP2C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="124"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="434"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ92670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="485" mass="51571" checksum="5884CAD2B4A9AC36" modified="2006-03-21" version="1">MARTVGVARVLSLPCRPTPKTFRMGVMANTKVSASFSSGPAVQQSATSGPTRATAAIQAFRQQQNPSVPRFPLSLMRPRALYSTSTSSSSQTPKFVYNIAASYIAKGRPYDPSTHVFQFNPYNRVQPPKAGRGKASRPESGQDAFFVSRLGAVPGEVALGVADGVGGWMDSGVDPADFSHAFCDYMASSAVAATTTPEGSGKPLTARQLMQKGYEAVCHDPAIKAGGSTAIVGLLTAEGLLEVANLGDSGFILLRLNGVHACSEPQTHAFNTPYQLSVVPPSMLLRAAKFGGAQLMDQPRDAEVSRIGLRHGDVLVLASDGLWDNLFNQDVLRIVSRTMAQAGAWTSTERGVQVAADLRPFTSLGETDTPASSHPTLQSMLATQLVSAAKSASVNRKLDGPFAKEVKKYYPHEVWHGGKEDDICTVVVLVSEEESPTKANSEHDNTRIGARRADNPTRDLDIGVTTEGLQKPTATSRAIPSVAEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFV3</accession>
    <name>Q2HFV3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_00901</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220122.1">
        <property type="nucleotide sequence ID" value="XM_001220121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFV3"/>
    <dbReference type="STRING" id="306901.Q2HFV3"/>
    <dbReference type="GeneID" id="4386353"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00901"/>
    <dbReference type="eggNOG" id="ENOG502QRKD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028484_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HFV3"/>
    <dbReference type="OMA" id="FRVTEAI"/>
    <dbReference type="OrthoDB" id="17415at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF5">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ92666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="342" mass="40018" checksum="694ED2582DD86CE7" modified="2006-03-21" version="1">MSDEFQRYPMVTALDLRGRNERPRRVKMLMRDFIEDSLYNPTYGYFSKQVVIFTPGEPFDFPSLYDELDFHSLLSRRYVEFENAMDAVSPSDTRQLWYTPTELFRPYYGEAIARYLIANYKLTTYPYHDLIIYEMGAGRGTLMLNILDHIRDVDPAVYDRTKYKIIEISTQLATIQNSQLKQSFAARGHADKVEIINQSIFDWTNPVPSPCFFLAFEVFDNFAHDILRYDMETQKPLQGMVLIDENGDFYEFYTPHLDPVAARDGLIPVSTPMVHQGYFDIMFPTNFSTAEATYQAITGKLTRVLTHEEFMRRWAYLEETETQSGENPLLTWYKNASVMFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG00</accession>
    <name>Q2HG00_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_00854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220075.1">
        <property type="nucleotide sequence ID" value="XM_001220074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG00"/>
    <dbReference type="GeneID" id="4388084"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00854"/>
    <dbReference type="HOGENOM" id="CLU_1786614_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HG00"/>
    <dbReference type="OrthoDB" id="5244771at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ92619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="145" mass="16228" checksum="E734FF43335B685B" modified="2006-03-21" version="1">MPCGEGVRPGGIYYDKGTLRVSNDTDLESNYLIATTNVTEWIRRSSRDDRFMPQWSFSFDSCGDDVLTRGHLMFNIATEEVITYEPGEIHRVMDVPGCPELGAIIQLRDNATASQCPLGEVVEAAEDVLRPGHSRCIQQHSEPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG69</accession>
    <name>Q2HG69_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein SKT5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220006.1">
        <property type="nucleotide sequence ID" value="XM_001220005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG69"/>
    <dbReference type="STRING" id="306901.Q2HG69"/>
    <dbReference type="GeneID" id="4386884"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00785"/>
    <dbReference type="eggNOG" id="KOG1550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_126_2_1"/>
    <dbReference type="InParanoid" id="Q2HG69"/>
    <dbReference type="OMA" id="GSHMRAP"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATOR SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="731"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="741"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ92550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="753" mass="81223" checksum="2F4A23A8469A9BBF" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG90</accession>
    <name>Q2HG90_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_00764</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219985.1">
        <property type="nucleotide sequence ID" value="XM_001219984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG90"/>
    <dbReference type="FunCoup" id="Q2HG90">
        <property type="interactions" value="399"/>
    </dbReference>
    <dbReference type="GeneID" id="4386732"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00764"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="InParanoid" id="Q2HG90"/>
    <dbReference type="OMA" id="CCKFTHY"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF315">
        <property type="entry name" value="TRANSPORTER MCH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="269"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ92529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="41245" checksum="993628F158861ECD" modified="2006-03-21" version="1">MTSPMATAPEPALPVSMKSKQNAPELFSGEKGTGSDDSPVETDSPEEAEFKEGGYGWVVVFSVLLVNAHTWGLNSSYAVFLAYYLRSGTIDGASPLGFAFVGGLSISIWFCFTSTVGVVPQWFTKRRSFANSVATCGSGFGGLTYALGTNAMISNLGLAWAFRILAILAFVVNGACSLILRDRNKAVGAVHIPFHKDLFKRLEFWLFVGWGFFSLLGYVIVVFSITDYAQSVGFTASQGSLAASIFNLSQGIGRPLIGLVSDRFGRINVAGVGTLIAGLAAFFLWIFAGSHFAGLIVYVLFGMFAGIIWPCVAPVGAEVVGLQLLPSVWLLRGWKLQQLELLGPDEKQQANTNLPDNGNQEQREPRHSGLRAYVNGMTVIKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGB4</accession>
    <name>Q2HGB4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_00740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family. Monothiol subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219961.1">
        <property type="nucleotide sequence ID" value="XM_001219960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGB4"/>
    <dbReference type="FunCoup" id="Q2HGB4">
        <property type="interactions" value="767"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HGB4"/>
    <dbReference type="GeneID" id="4386926"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00740"/>
    <dbReference type="eggNOG" id="KOG0911">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026126_12_0_1"/>
    <dbReference type="InParanoid" id="Q2HGB4"/>
    <dbReference type="OMA" id="WAEPCKT"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02984">
        <property type="entry name" value="TRX_PICOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000012">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000092">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF73">
        <property type="entry name" value="GLUTAREDOXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ92505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="260" mass="28054" checksum="E79E886F823331A1" modified="2006-03-21" version="1">MSNIEEITSVVAWEKHISSLPTSTLLIVSFHAPWAAPCAQMATVLSTLASEYPATEPRSTSWVKINAEELSDISEAYDVTAVPFLVLIRNGEVLETVSGSSAVKVREAIEKHASKAGAATTTNNGAAPAPGLGEAEVNTEEDPEKKKQELFRRLGDLVKAAPVMLFMKGTPSEPKCGFSRQLVAILRDNAVKYGFFNILADDEVRQGLKEFADWPTFPQLWVDGELVGGLDIVKEELDSNADFLKPYSVKANGDTSAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGJ9</accession>
    <name>Q2HGJ9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219876.1">
        <property type="nucleotide sequence ID" value="XM_001219875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGJ9"/>
    <dbReference type="STRING" id="306901.Q2HGJ9"/>
    <dbReference type="GeneID" id="4386796"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00655"/>
    <dbReference type="eggNOG" id="ENOG502QVJ3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1042071_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGJ9"/>
    <dbReference type="OrthoDB" id="5095644at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718">
        <property type="entry name" value="OS01G0519700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718:SF10">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="1">
        <location>
            <begin position="41"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="267" mass="29939" checksum="BC30797B9A3ADBE6" modified="2006-03-21" version="1">MLRETGTYHVVRIDPTDHHKITGLFWTYPWCIEMWRKYPLVLQLDNTYKTNRFSMLLFQATGVTNVTTTFNAAFGLVDNEREDGFGWLAQQLLACQLHYGIESSGVVITDFDKALKNALKDHLPDAHQQICAFHINKNVVLNIKRKWKKTDDENQQPLAPNIADEAFADPILLEEADKHQLRQLNAPLADGEDLGAIRLPSEGEVAHSNSFATTHRERPTCAYPMFLLSTQSLACPSQGSLSIHPKPCCPSQGLLSVPKPAVHPKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGN6</accession>
    <name>Q2HGN6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219839.1">
        <property type="nucleotide sequence ID" value="XM_001219838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGN6"/>
    <dbReference type="GeneID" id="4386993"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00618"/>
    <dbReference type="eggNOG" id="ENOG502RHRP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181675_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGN6"/>
    <dbReference type="OMA" id="FRPDCWP"/>
    <dbReference type="OrthoDB" id="5204810at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="80" mass="8745" checksum="04CD54199D14F68A" modified="2006-03-21" version="1">MSSHVATPLAAPIPIPAPRRNLGLITTQELFASLNATLASKMDELVTPIHHIREADYSVPAPPPPSPVSFRDHWPASMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH06</accession>
    <name>Q2HH06_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_00498</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219719.1">
        <property type="nucleotide sequence ID" value="XM_001219718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH06"/>
    <dbReference type="GeneID" id="4387923"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00498"/>
    <dbReference type="eggNOG" id="KOG4231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_144_6_1"/>
    <dbReference type="InParanoid" id="Q2HH06"/>
    <dbReference type="OMA" id="PEFDCTI"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07216">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF4">
        <property type="entry name" value="SERINE HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G07870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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</entry>
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        <source>
            <dbReference type="EMBL" id="EAQ91967.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHV4</accession>
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            <fullName evidence="3">DUF7136 domain-containing protein</fullName>
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    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219421.1">
        <property type="nucleotide sequence ID" value="XM_001219420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHV4"/>
    <dbReference type="GeneID" id="4387500"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00200"/>
    <dbReference type="eggNOG" id="ENOG502TM7I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_858353_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHV4"/>
    <dbReference type="OMA" id="AVAFNIQ"/>
    <dbReference type="OrthoDB" id="4490227at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055560">
        <property type="entry name" value="DUF7136"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23584">
        <property type="entry name" value="DUF7136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209270" description="DUF7136 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7136" evidence="3">
        <location>
            <begin position="24"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ91965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="293" mass="31249" checksum="4ED147D2EA9DA2B8" modified="2006-03-21" version="1">MVYCWLWASAALAALGAAAEVVTTTRQFEVDIVFPHNETYKPAETMPIVLAIQNPAVALSIGHFSVFWTISQVQGWDTIGSSVDFGDFQVFSNLTSTDPTLFLVGFTNVTDWIRYGRPTPPATEYTPGPHDRYLLQWSIVWTSLFGNCTKFESLVGADLPSEGAVAFNIQTVWGEGGWQGEIHDVQEGIPECPEFGGLVQIGPPPNATKPACPGFEILEGREGNPCAVTIDQPAASSIWSRVSTSVASSMSRYHPTPTTTAAVESSTSSGGVGPARTMQTALAAACVLCGLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI84</accession>
    <name>Q2HI84_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219291.1">
        <property type="nucleotide sequence ID" value="XM_001219290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HI84"/>
    <dbReference type="GeneID" id="4386585"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00070"/>
    <dbReference type="HOGENOM" id="CLU_3392236_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HI84"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="32" mass="3511" checksum="6F755F30F0E342A7" modified="2006-03-21" version="1">MAREPHLRRESPWSVLHPPLSTDSTNEAPGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HID1</accession>
    <name>Q2HID1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219244.1">
        <property type="nucleotide sequence ID" value="XM_001219243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HID1"/>
    <dbReference type="GeneID" id="4387590"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00023"/>
    <dbReference type="HOGENOM" id="CLU_2037787_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HID1"/>
    <dbReference type="OrthoDB" id="61113at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="121" mass="13350" checksum="B04D8D9EC77E5DFF" modified="2006-03-21" version="1">MLLDLVVMAVPIPIYFEQGARGRTRLGLVGIIAMGTVIPVFWGPMMTSASHLLGQIFVTKEVQVTTEHRFGNLGSSDAFHQHEGPWADLEDGKAYLEQRCGSRVEWTGKDGAQHHSTTWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMK4</accession>
    <name>Q2GMK4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ82982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226067.1">
        <property type="nucleotide sequence ID" value="XM_001226066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMK4"/>
    <dbReference type="STRING" id="306901.Q2GMK4"/>
    <dbReference type="GeneID" id="4397106"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10800"/>
    <dbReference type="eggNOG" id="ENOG502R9MT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039534_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GMK4"/>
    <dbReference type="OMA" id="NMYVAFH"/>
    <dbReference type="OrthoDB" id="507128at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054539">
        <property type="entry name" value="Beta-prop_PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22807">
        <property type="entry name" value="TrAA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004207948" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller" evidence="2">
        <location>
            <begin position="42"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ82982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="437" mass="46662" checksum="D6C8A196C56FF85F" modified="2006-03-21" version="1">MRLFETAVAVAALFAAGTDAQIPKLPLPKSCSGVSNFRYQYTVASGWSAMKLAGGLKQVRTVIWDPAGNLLVAQATKGISVHTFGADGCLNSTNMLISGGQLNHGLALSPDGKKLYASGETAAYSWDYNVATRTVSNQKTVIKGISSGIHFTRTLAVVPQQPNLLLVQVGSNANLDMAAAQKETGRAIIKIFDTDKAPTSGFNYNTDGEVYGYGLRNTIGFTADPSGVFWGVENSGDDFRRSENGQNRDIHQNNPAEELNNLGNPLTTRNVWYGYPTCFAVWDPSSFSGLKTGSNFVLSPSSSFNDASCNGQATPPRLSFQAHSAPIWNTFDTDAKNMYVAFHGSWDRQPPTGFKVVQIPFQKLADGSYDPVAPADSQTGYKDIFSAPNPGGCTANGLTQSNCFRLTAAAWDPAGRGLFVGSDNSAEGEIYILSPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMV6</accession>
    <name>Q2GMV6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228625.1">
        <property type="nucleotide sequence ID" value="XM_001228624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMV6"/>
    <dbReference type="GeneID" id="4396336"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10698"/>
    <dbReference type="HOGENOM" id="CLU_1844855_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GMV6"/>
    <dbReference type="OrthoDB" id="10437941at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="139" mass="15633" checksum="941D3674C9D2435A" modified="2006-03-21" version="1">MMLAGLQMDMPVPGGTPGAWRNVRGTSTSERFLCLEERARNECLEERARNECLEERARNECLEERARNECLEERARNEYTSERFLLPGGTCEERVPGGTCEERVPGGTCEERVLPKGSFSEKNHGMLQARTSSGPIKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNE0</accession>
    <name>Q2GNE0_CHAGB</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10514</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Soil fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNE0"/>
    <dbReference type="GeneID" id="4396858"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10514"/>
    <dbReference type="eggNOG" id="ENOG502RQPW">
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    <dbReference type="HOGENOM" id="CLU_342923_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNE0"/>
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    </dbReference>
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        <location>
            <begin position="462"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="764" mass="85232" checksum="F9E7C50D297C6764" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNK1</accession>
    <name>Q2GNK1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ84049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228380.1">
        <property type="nucleotide sequence ID" value="XM_001228379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNK1"/>
    <dbReference type="GeneID" id="4396803"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10453"/>
    <dbReference type="eggNOG" id="ENOG502S3SW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082473_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GNK1"/>
    <dbReference type="OMA" id="LHEAVNW"/>
    <dbReference type="OrthoDB" id="4556768at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="254" mass="30414" checksum="9A119313C404EEEE" modified="2006-03-21" version="1">MLWQRLKEICIYFWNFRYLPLKYRWLLIKFRRRFLPTQTGLGLRNALRHARSLKHPPEPHPYLFVLRLLWPFPTWDFRAVLPPPPRAIMANPEGVRCRVRDLIYLRSMPLWRARDTPQRSFYRLYEAFCAADGHMITYETEYFWRRSSPRWAVANLPDPECADPEQYAVMAALADVLVDSFTWRLELGLRRTDQPIVHRSADALPFTPETHPSWTAKVPPLQEKLVIHPEEDVYFDSPLHRRNVYMATGWFYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNL2</accession>
    <name>Q2GNL2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_10442</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228369.1">
        <property type="nucleotide sequence ID" value="XM_001228368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNL2"/>
    <dbReference type="STRING" id="306901.Q2GNL2"/>
    <dbReference type="GeneID" id="4396993"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10442"/>
    <dbReference type="eggNOG" id="ENOG502RYZ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007073_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GNL2"/>
    <dbReference type="OMA" id="CTKNGHQ"/>
    <dbReference type="OrthoDB" id="2354469at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="327"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
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        </location>
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    </feature>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ84038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1002" mass="111602" checksum="F555DEEC8D28FA3C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GP69</accession>
    <name>Q2GP69_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228162.1">
        <property type="nucleotide sequence ID" value="XM_001228161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GP69"/>
    <dbReference type="GeneID" id="4396827"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10235"/>
    <dbReference type="eggNOG" id="ENOG502T15E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_425774_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GP69"/>
    <dbReference type="OMA" id="SEYIRHG"/>
    <dbReference type="OrthoDB" id="3903267at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
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            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="643" mass="70719" checksum="0505B73FBA9F9379" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPM9</accession>
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    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228002.1">
        <property type="nucleotide sequence ID" value="XM_001228001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPM9"/>
    <dbReference type="GeneID" id="4396626"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10075"/>
    <dbReference type="eggNOG" id="ENOG502T79F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_468506_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPM9"/>
    <dbReference type="OMA" id="GDCINDG"/>
    <dbReference type="OrthoDB" id="4590622at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="582" mass="56178" checksum="D56F893B4F77943B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPW1</accession>
    <name>Q2GPW1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_09993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227920.1">
        <property type="nucleotide sequence ID" value="XM_001227919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPW1"/>
    <dbReference type="FunCoup" id="Q2GPW1">
        <property type="interactions" value="507"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GPW1"/>
    <dbReference type="GeneID" id="4396662"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09993"/>
    <dbReference type="eggNOG" id="KOG1050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002351_7_2_1"/>
    <dbReference type="InParanoid" id="Q2GPW1"/>
    <dbReference type="OMA" id="NRTIWPL"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000035">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF106">
        <property type="entry name" value="BCDNA.GH08860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ83589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="479" mass="53365" checksum="0E521158671B5163" modified="2006-03-21" version="1">MPGAVEYPASSSGRLLLISNRLPITIKRSDEGHYSFSMSSGGLVPEGEAGPMRGQLKEKHNAIPVFVDDELADRHYNGFANSILWPLFHYHPGEITFDESAWAAYREVNRLFAQTVVKDVQDGDLVWVHDYHLMLLPQMLREEIGNSKKNVKIGFFLHTPFPSSEIYRILPVREQLLLGILDCDLIGFHTYDYARHFLSSCSRILSTTTTPNGVDWNGRFVTVGAFPIGIDPEKFIEGLKKENVQNRIAALKLFLTEHPEWIGKIVLVQVAVPSRQDVEEYQNLRAVVNELVGRINGKFGTIEFMPIHFLHQSVTFDELTALYAVSDVCLVSSTRDGMNLVSYEYIATQRERHGVMILSEFTGAAQSLNGSLIVNPWNTEELANAIHDAVTMSPQQRATNFRKLERYVFKYTSAWWGQSFVTELTRLNAGEESKAGKKGNAAQLALQSAAEGVAGATNKAVEGAQEAIAAVSGDNKESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQZ0</accession>
    <name>Q2GQZ0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DNA mismatch repair protein msh-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_09614</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of msh2 and msh6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227541.1">
        <property type="nucleotide sequence ID" value="XM_001227540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQZ0"/>
    <dbReference type="FunCoup" id="Q2GQZ0">
        <property type="interactions" value="961"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GQZ0"/>
    <dbReference type="GeneID" id="4396749"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09614"/>
    <dbReference type="eggNOG" id="KOG0219">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_10_0_1"/>
    <dbReference type="InParanoid" id="Q2GQZ0"/>
    <dbReference type="OMA" id="LVRFPQK"/>
    <dbReference type="OrthoDB" id="295033at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032302">
        <property type="term" value="C:MutSbeta complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000406">
        <property type="term" value="F:double-strand/single-strand DNA junction binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032137">
        <property type="term" value="F:guanine/thymine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000404">
        <property type="term" value="F:heteroduplex DNA loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032138">
        <property type="term" value="F:single base insertion or deletion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007534">
        <property type="term" value="P:gene conversion at mating-type locus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043570">
        <property type="term" value="P:maintenance of DNA repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006311">
        <property type="term" value="P:meiotic gene conversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000735">
        <property type="term" value="P:removal of nonhomologous ends"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03285">
        <property type="entry name" value="ABC_MSH2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000003">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000523">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000015">
        <property type="entry name" value="DNA mismatch repair protein Msh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000017">
        <property type="entry name" value="DNA mismatch repair protein Msh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032642">
        <property type="entry name" value="Msh2_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF35">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="12">
        <location>
            <begin position="733"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="861"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ83210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="942" mass="105177" checksum="8EFB4446BA531ED8" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GR47</accession>
    <name>Q2GR47_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ASCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227484.1">
        <property type="nucleotide sequence ID" value="XM_001227483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GR47"/>
    <dbReference type="GeneID" id="4394695"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09557"/>
    <dbReference type="eggNOG" id="ENOG502RNZD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102450_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GR47"/>
    <dbReference type="OMA" id="PLHWGVG"/>
    <dbReference type="OrthoDB" id="5511151at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06553">
        <property type="entry name" value="ASCH_Ef3133_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.10">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009326">
        <property type="entry name" value="DUF984"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39203:SF1">
        <property type="entry name" value="CYTOPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39203">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04266">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01022">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASCH" evidence="1">
        <location>
            <begin position="33"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="171" mass="18656" checksum="5A4B470DFEB6B7B4" modified="2006-03-21" version="1">MSSVDPSRPDIVVFMARASATLGRALPPPKDIFHFGGSSPRLADERLHLAIEGKKSATTSWPVPEPLHWGVGDLSVILDGAGRPRALMRTTSLVQCSFRDVEEDFALAEAEGDYEAYRTGHVAFYREQEGGEAFGEDSIVLCERFEVIYSAEARGEDDGLVEDVGAGQNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRJ4</accession>
    <name>Q2GRJ4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_09410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227337.1">
        <property type="nucleotide sequence ID" value="XM_001227336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRJ4"/>
    <dbReference type="STRING" id="306901.Q2GRJ4"/>
    <dbReference type="GeneID" id="4394895"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09410"/>
    <dbReference type="eggNOG" id="ENOG502S9DW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041821_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRJ4"/>
    <dbReference type="OMA" id="WDSHVRG"/>
    <dbReference type="OrthoDB" id="77607at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040050">
        <property type="entry name" value="ZNF830-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="56"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="350"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="293"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ85396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="387" mass="41144" checksum="E7840ED78E4FF2D0" modified="2006-03-21" version="1">MADVRALLRQQRAARRVEHPHALYSDAGKLVCTVCNEQVKTESLWDKHLRSAGHRQRLQSIHQSSTKNGSNGYAGFVDQGSEATGPTNKRKLADSDEDMADADETISRKKRTKPDGSPTEHSQQGTRTPAKKDDGGNPTTPPLSRRTSGTPTAGVEMQIASRPATPGPGGTGTPMATTPRAAPVGRSPLIPDEATTSQQDSIRGPRPAAQPAPATTTATTATTTVDEKEWAAFEADLINDKPPQTNTKPAAAAALLASDAVISAPVMSAAEIAAKSEEEERARRRALVDIQIEDEKEEATRALENEFEVMEELEARAKKLRERREALRVQSNGGTAVAAAPVGVGVVVGAGGKGAAASGEGKENAAVEEEEDDEDDEDDWDGFRFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GS21</accession>
    <name>Q2GS21_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytidyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_09233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227160.1">
        <property type="nucleotide sequence ID" value="XM_001227159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GS21"/>
    <dbReference type="STRING" id="306901.Q2GS21"/>
    <dbReference type="GeneID" id="4395521"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09233"/>
    <dbReference type="eggNOG" id="KOG3199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1229805_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GS21"/>
    <dbReference type="OMA" id="MCELATA"/>
    <dbReference type="OrthoDB" id="422187at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="2">
        <location>
            <begin position="49"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ85219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="225" mass="24358" checksum="D2A9CFD20B8751AD" modified="2006-03-21" version="1">MTAGTINSDTQTPTAMGPAVDGAQAPYNFPTQKLKRQMTQPGKTPLVLVACGSFSPITYLHLRMFEMAGDFVRFNTDFEVCAGYLSPVSDAYKKVGLAPGSHRVNMCGRAVEQSPWLMVDPFETVNCDENGEPQYVPTAKVLRHFDHEINTVLGGIEAPDGQMKKARIALLAGADLVMSMGGFDTGSRVSNVKLTCTRGAWALGSKGSGHDPRVVRRFHHRALGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSK1</accession>
    <name>Q2GSK1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_09053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226980.1">
        <property type="nucleotide sequence ID" value="XM_001226979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSK1"/>
    <dbReference type="GeneID" id="4395312"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09053"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_349161_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSK1"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="110"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="287"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ85039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="807" mass="88448" checksum="E87841C06208B05B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GT01</accession>
    <name>Q2GT01_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226830.1">
        <property type="nucleotide sequence ID" value="XM_001226829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GT01"/>
    <dbReference type="STRING" id="306901.Q2GT01"/>
    <dbReference type="GeneID" id="4395283"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08903"/>
    <dbReference type="eggNOG" id="ENOG502RKMH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1859993_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GT01"/>
    <dbReference type="OMA" id="HKVHRNT"/>
    <dbReference type="OrthoDB" id="2537769at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="167" mass="18168" checksum="2A9919A126CAA5D6" modified="2006-03-21" version="1">MAAALRACYKPNSIMPGRKRKSAPAAEEPSAAADAPATRRRSLRVSSTGQKSKYFEAGSESDADQDGNTLGNGRGKGRLSKKVRVEVESDGNEDDYKEEEDDDDDEDGTAGTSGAVNRDAEESDEEFDEDAPPKVTFIPHIKLRDTNGIEYEDHTVHPNTLAFPPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GT65</accession>
    <name>Q2GT65_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226766.1">
        <property type="nucleotide sequence ID" value="XM_001226765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GT65"/>
    <dbReference type="STRING" id="306901.Q2GT65"/>
    <dbReference type="GeneID" id="4395567"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08839"/>
    <dbReference type="eggNOG" id="ENOG502RJF6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066466_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GT65"/>
    <dbReference type="OMA" id="FNAEWIV"/>
    <dbReference type="OrthoDB" id="2862635at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00977">
        <property type="entry name" value="SCYTLDPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208576" evidence="2">
        <location>
            <begin position="18"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="273" mass="28748" checksum="A27C5187B05F0747" modified="2006-03-21" version="1">MKLTAILHTALLGSAAAISSFTGPSNKPSLPAVRRSRLTDRLNGVSSQAAPDDLPGVTYSKNWAGAILTGIGYRSVTATIHVPSIRLPPGAQSDVLHAVSAWVGIDGEHACPNAILQVGVDMYMNHSDPAYWAWFEWYPSRSTYLTDFSISAGDSITLNVSATSLSSATFAITNHNTGQTDIATLNDQAPLMCGFNAEWIVEDFWDTDGVPLVDFGSVAFTGAMFSTDLGIGGGMEGAKMDGIKEGLVGDPVIECEKLGGDAMSCSYKGGKHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTS1</accession>
    <name>Q2GTS1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_08633</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226560.1">
        <property type="nucleotide sequence ID" value="XM_001226559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTS1"/>
    <dbReference type="FunCoup" id="Q2GTS1">
        <property type="interactions" value="211"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GTS1"/>
    <dbReference type="GeneID" id="4395603"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08633"/>
    <dbReference type="eggNOG" id="KOG0380">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018190_2_1_1"/>
    <dbReference type="InParanoid" id="Q2GTS1"/>
    <dbReference type="OMA" id="INWWYVA"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034737">
        <property type="term" value="F:ergosterol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008204">
        <property type="term" value="P:ergosterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF23">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="582"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ84619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="605" mass="68300" checksum="ED1BD2F6C5E273AF" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUV4</accession>
    <name>Q2GUV4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225906.1">
        <property type="nucleotide sequence ID" value="XM_001225905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUV4"/>
    <dbReference type="STRING" id="306901.Q2GUV4"/>
    <dbReference type="GeneID" id="4393641"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08250"/>
    <dbReference type="eggNOG" id="ENOG502RPQ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024519_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GUV4"/>
    <dbReference type="OMA" id="WRYELDP"/>
    <dbReference type="OrthoDB" id="5280838at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38119:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38119">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="500"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="505"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ86997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="676" mass="72986" checksum="E66ECFA77EF86096" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUZ1</accession>
    <name>Q2GUZ1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_08213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225869.1">
        <property type="nucleotide sequence ID" value="XM_001225868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUZ1"/>
    <dbReference type="GeneID" id="4394246"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08213"/>
    <dbReference type="eggNOG" id="ENOG502S016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024593_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUZ1"/>
    <dbReference type="OMA" id="ACDAFHL"/>
    <dbReference type="OrthoDB" id="5398371at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ86960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="499" mass="56051" checksum="2CCA521EEC1BA3EC" modified="2006-03-21" version="1">MDDAADGQDGESADLATKLGFPIVDIVPDGDILLDVTFETSKETLKAARKAAKPRPGQKVTPPVFKARNRVGYRVQLSALKQNSKYFDNLLSDTRFAEARSIEESFQRLSLKNVKPSEADAGDLPLVKIHEDDEATRSAGHNSVFEDLLRILHRKQSTAKAVTMQHLAVLALLADRFNCIAIVSRYLNALKYKWPATQTRVSRDDGPTLSRATEETLRQKILVAWLLDQPPKLQVATRELIMYGSRRWSEYLDEEQEESYAAAWWDLPDDLEQELHHRRERILTTIASIQTHFLGLYTSRTRQCKLGYDSSASCDSYQLGEMIKFLCSRNLLFLTSFTPSPFLSPSISSSTLPETPDISTTDIGSILATLKQCPAYQIDKNHTHCGLRARALPAVEYVQAMLASGAVAIARPAWVRDREGAAWRSSLGVEGGHDGDGKRERKVFRFTRGLATDQRLRMEGAMAVDRSARALFTADEWDWSTEDRDETRGVEFGRWPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV39</accession>
    <name>Q2GV39_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_08165</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225821.1">
        <property type="nucleotide sequence ID" value="XM_001225820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV39"/>
    <dbReference type="FunCoup" id="Q2GV39">
        <property type="interactions" value="786"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GV39"/>
    <dbReference type="GeneID" id="4393294"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08165"/>
    <dbReference type="eggNOG" id="KOG1077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003824_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GV39"/>
    <dbReference type="OMA" id="PVLMHRY"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017104">
        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003164">
        <property type="entry name" value="Clathrin_a-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02296">
        <property type="entry name" value="Alpha_adaptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="3 7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="9">
        <location>
            <begin position="703"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="21"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ86912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="979" mass="109031" checksum="21A67662DBD31129" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVS1</accession>
    <name>Q2GVS1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225589.1">
        <property type="nucleotide sequence ID" value="XM_001225588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVS1"/>
    <dbReference type="STRING" id="306901.Q2GVS1"/>
    <dbReference type="GeneID" id="4393972"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07933"/>
    <dbReference type="eggNOG" id="KOG3272">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2014996_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GVS1"/>
    <dbReference type="OrthoDB" id="200398at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039730">
        <property type="entry name" value="Jlp2/Ccd25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049">
        <property type="entry name" value="DUF814-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="123" mass="14271" checksum="C523D608C3AFBC94" modified="2006-03-21" version="1">MVFYFTSNVVEPSAFVYVGKDKFESNKKDNITIIYTPWSNLKKDGSMAVGQVSFKDNRKVKKILVPQRENPIVNRLNKTKVEQYPDLKQEKDDHLRELRKKDQAAQLARASLPDFHSSSCHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWA5</accession>
    <name>Q2GWA5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225405.1">
        <property type="nucleotide sequence ID" value="XM_001225404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWA5"/>
    <dbReference type="GeneID" id="4393423"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07749"/>
    <dbReference type="HOGENOM" id="CLU_903150_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWA5"/>
    <dbReference type="OrthoDB" id="4588800at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="308" mass="33016" checksum="28ED2A34779E8427" modified="2006-03-21" version="1">MSPLDNGSVQHHITLSRKIIPYLQMSVSFANILGKKFGTPSTSVANKGTAGPGVLFPLPQLADTFYLYGAMNIASMANQGRGRGRGNHNNNNNRNGNGNGNGHGNGNRSNRSGNGNGNGNRNWDDNSSRHRNGDRNNGWNNSRGISKAGRYNNNGGSSRGRPRSASPKTLKTLVLDTLRAPADAIDPKPFIELSVATSLAGGLLIDTLVQLDFTNREIARTLAVPLSNLLQLHSITRLLIDGNREPDAEGDHPMFDSDAEEPVEYGQRTNRLARGDGQNGQNGQNGRSNISENQLALAKFIASDIGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWD7</accession>
    <name>Q2GWD7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF410 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_07717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GET4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225373.1">
        <property type="nucleotide sequence ID" value="XM_001225372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWD7"/>
    <dbReference type="FunCoup" id="Q2GWD7">
        <property type="interactions" value="330"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GWD7"/>
    <dbReference type="GeneID" id="4393376"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07717"/>
    <dbReference type="eggNOG" id="KOG3024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046061_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GWD7"/>
    <dbReference type="OMA" id="LMDMMGM"/>
    <dbReference type="OrthoDB" id="10252405at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000272">
        <property type="entry name" value="DUF410 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ86464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="36440" checksum="8505ABE4925C7CDA" modified="2006-03-21" version="1">MASKIEKIIARLQKRIAEGAFEEQYEAAQETRLVAARYTKQANWPAAVDILSNVSQALLRAGQGGSGGDLAILLVDVYRQAAQKPDGASRGKLLTCLRLFEREEPTRKKFIKEMIEWSKKFGEFPAGDPELHHVVGALFAEEHEAEEAERHLILGTKESAEVLSRMEYDWYKEDESHTAPLYCARAVLPYLLVANVRAANASYRTFVSALAADNKGLAVQDVSSQGSDVRIFPSLPLLNFLGLLLLAVQKGTPDLFRQLKTKYGPNINELGDTWDTALEMIAEMYFGIQRPRQSNPLFDMMGSLFGGGAPGGGQSRPAARRVEAPAAEGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWH0</accession>
    <name>Q2GWH0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycosyl hydrolase family 32 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_07684</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225340.1">
        <property type="nucleotide sequence ID" value="XM_001225339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWH0"/>
    <dbReference type="STRING" id="306901.Q2GWH0"/>
    <dbReference type="GeneID" id="4393609"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07684"/>
    <dbReference type="eggNOG" id="KOG0228">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_367216_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWH0"/>
    <dbReference type="OrthoDB" id="4573042at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF1">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="6">
        <location>
            <begin position="16"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="6">
        <location>
            <begin position="418"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="7">
        <location>
            <begin position="495"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="6">
        <location>
            <begin position="714"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="651"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="655"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ86431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="759" mass="80561" checksum="C43FC11699B5CC4F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWH7</accession>
    <name>Q2GWH7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">NAD(P) transhydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">7.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Nicotinamide nucleotide transhydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">CHGG_07677</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>NAD(+) + NADPH + H(+)(in) = NADH + NADP(+) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the C-terminal section; belongs to the PNT beta subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225333.1">
        <property type="nucleotide sequence ID" value="XM_001225332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWH7"/>
    <dbReference type="STRING" id="306901.Q2GWH7"/>
    <dbReference type="GeneID" id="4393597"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07677"/>
    <dbReference type="eggNOG" id="ENOG502QQ0A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003376_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWH7"/>
    <dbReference type="OMA" id="EQCREVD"/>
    <dbReference type="OrthoDB" id="37244at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:proton-translocating NAD(P)+ transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05304">
        <property type="entry name" value="Rubrum_tdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000028">
        <property type="entry name" value="NAD(P) transhydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000002">
        <property type="entry name" value="NAD(P) transhydrogenase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008143">
        <property type="entry name" value="Ala_DH/PNT_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026255">
        <property type="entry name" value="NADP_transhyd_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024605">
        <property type="entry name" value="NADP_transhyd_a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034300">
        <property type="entry name" value="PNTB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00561">
        <property type="entry name" value="pntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006942">
        <property type="entry name" value="PRK09424.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160">
        <property type="entry name" value="NAD(P) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160:SF19">
        <property type="entry name" value="PROTON-TRANSLOCATING NAD(P)(+) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02233">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12769">
        <property type="entry name" value="PNTB_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00837">
        <property type="entry name" value="ALADH_PNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 25" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
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        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="487"/>
            <end position="506"/>
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    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="518"/>
            <end position="538"/>
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    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="550"/>
            <end position="573"/>
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    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="594"/>
            <end position="616"/>
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    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="636"/>
            <end position="656"/>
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    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="668"/>
            <end position="688"/>
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        <location>
            <begin position="51"/>
            <end position="216"/>
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            <begin position="252"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="24">
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            <begin position="255"/>
            <end position="269"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00061558"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00079255"/>
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    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="EAQ86424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="897" mass="93026" checksum="C586C38A0CE9456A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWP7</accession>
    <name>Q2GWP7_CHAGB</name>
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        <recommendedName>
            <fullName evidence="3">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
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        <alternativeName>
            <fullName evidence="11">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
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        <name evidence="17" type="ORF">CHGG_07607</name>
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        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <reaction evidence="12">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
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            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
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        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
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    <dbReference type="HOGENOM" id="CLU_001882_1_2_1"/>
    <dbReference type="InParanoid" id="Q2GWP7"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
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        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
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    </dbReference>
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        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
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        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
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        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
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        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
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        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="14">
        <location>
            <begin position="121"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="15">
        <location>
            <begin position="429"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="16">
        <location>
            <begin position="533"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAQ86354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="638" mass="72625" checksum="C8E82825B7ADEF5C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWS6</accession>
    <name>Q2GWS6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_07578</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225234.1">
        <property type="nucleotide sequence ID" value="XM_001225233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWS6"/>
    <dbReference type="STRING" id="306901.Q2GWS6"/>
    <dbReference type="GeneID" id="4393965"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07578"/>
    <dbReference type="eggNOG" id="KOG0849">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023524_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GWS6"/>
    <dbReference type="OMA" id="SHADPMI"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057939">
        <property type="entry name" value="TRF2_HOY1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24818">
        <property type="entry name" value="PH_TRF2_HOY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="84"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="86"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ86325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="627" mass="69007" checksum="225F1299025A01AD" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX52</accession>
    <name>Q2GX52_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_07452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225108.1">
        <property type="nucleotide sequence ID" value="XM_001225107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX52"/>
    <dbReference type="STRING" id="306901.Q2GX52"/>
    <dbReference type="GeneID" id="4393652"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07452"/>
    <dbReference type="eggNOG" id="ENOG502SJB0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_4_0_1"/>
    <dbReference type="InParanoid" id="Q2GX52"/>
    <dbReference type="OMA" id="LWSAMYD"/>
    <dbReference type="OrthoDB" id="4587430at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF82">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="174"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="884"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ86199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="921" mass="103206" checksum="0D8EE57EFD17312E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXF1</accession>
    <name>Q2GXF1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225009.1">
        <property type="nucleotide sequence ID" value="XM_001225008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXF1"/>
    <dbReference type="GeneID" id="4393756"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07353"/>
    <dbReference type="eggNOG" id="ENOG502SVSH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151399_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GXF1"/>
    <dbReference type="OMA" id="MVRISHN"/>
    <dbReference type="OrthoDB" id="3920481at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="105" mass="11027" checksum="875D392589329A74" modified="2006-03-21" version="1">MPATATRPPQVPYTGGASSSSSSSSSYSASDSDLPSSGTMSSTVAVRTSMESVSRTPVQVAVIRCLRCARAEELTSTDDPRLSGMVQIGTNIYYCNRCAKMVGYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXR9</accession>
    <name>Q2GXR9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_07235</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224891.1">
        <property type="nucleotide sequence ID" value="XM_001224890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXR9"/>
    <dbReference type="FunCoup" id="Q2GXR9">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GXR9"/>
    <dbReference type="GeneID" id="4393939"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07235"/>
    <dbReference type="eggNOG" id="ENOG502QSWP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025694_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GXR9"/>
    <dbReference type="OMA" id="QQSFKGY"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF41">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208713" description="Mannan endo-1,6-alpha-mannosidase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ85982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="458" mass="49493" checksum="BBDC6B4DE89FFF01" modified="2006-03-21" version="1">MRISGLVASLGLLVGSGKAIELVLEDEASVKAAASTIAFGLVKYYTGNNTGDTPGNLPDPYFWWEAGAMFGTLIDYWALTGDDSYNAITAQALLHQGTENGDFKPRNQTRTLGNDDQGFWGMAAMSAAENKLPDPPPDQPQWLALAQSLFNQFASRWDEEACGGGLRWQIFTFNNGFNYKNSISNGCFFNIAARLARYTGNETYAEWADKIFAWEEKVGLITEDHTVRDGVHVNIDTKTCESMDPNRWTYNAGIFLHGAAVMYNHTNASSIWQTRVDGLLQSARATFFNDDGVVFEQLCEPSGFCNNDQRSFKGYLTRWLAGTTQMAPYTFDAIHPLLENDARAAAAVCIGDTPAPAFKGHSGTACGFSWTTPGRFDGSVGVGEQMNALSAVMYTLVGRVAAPVTADTGGTSKGNPNAMEHEEPLGYKEITLGDRVAAGFVTSALALGVVAGSAFVMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXX4</accession>
    <name>Q2GXX4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_07180</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224836.1">
        <property type="nucleotide sequence ID" value="XM_001224835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXX4"/>
    <dbReference type="STRING" id="306901.Q2GXX4"/>
    <dbReference type="GeneID" id="4393408"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07180"/>
    <dbReference type="eggNOG" id="KOG0608">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1034393_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GXX4"/>
    <dbReference type="OMA" id="RIMGECE"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="57"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ85927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="269" mass="30628" checksum="5F42CFD6DE15A402" modified="2006-03-21" version="1">MDTFHFSPTPKRDSGKYGPRARANRELCYTSVARFNGDALVKLKQINNRAKEGLDNYTIINPIGQGGFGLVNLVRRKQNGRVYALKQIPKKGTMESRQAMERMCTERCALADADSEWIVKLYTAFQDGTNFYFLFEYLPGGDLEALLRRNIRFHDRTAAFYLAEIVLALETVHNLGFIHRDLKPANILLDRQGHVKLTNFGLSKSRHKTVFYGHYGYLVRDSAWDSTVDISNETSSVRGSANYVKEVVGTSQYMAPEVVKDQEYSFKSD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-03-18" modified="2025-06-18" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GY21</accession>
    <name>LKHA4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Leucine aminopeptidase 2</fullName>
            <ecNumber>3.4.11.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Epoxide hydrolase</fullName>
            <ecNumber>3.3.2.10</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName>Leukotriene A-4 hydrolase homolog</fullName>
            <shortName>LTA-4 hydrolase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">CHGG_07133</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Aminopeptidase that preferentially cleaves di- and tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze the epoxide leukotriene LTA(4) but it forms preferentially 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than the cytokine leukotriene B(4) as the product compared to the homologous mammalian enzyme (in vitro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>an epoxide + H2O = an ethanediol</text>
            <dbReference type="Rhea" id="RHEA:19037"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32955"/>
            <dbReference type="ChEBI" id="CHEBI:140594"/>
            <dbReference type="EC" id="3.3.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-"/>
    <dbReference type="EC" id="3.3.2.10"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224789.1">
        <property type="nucleotide sequence ID" value="XM_001224788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GY21"/>
    <dbReference type="SMR" id="Q2GY21"/>
    <dbReference type="FunCoup" id="Q2GY21">
        <property type="interactions" value="906"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GY21"/>
    <dbReference type="MEROPS" id="M01.034"/>
    <dbReference type="GeneID" id="4393714"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07133"/>
    <dbReference type="eggNOG" id="KOG1047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014505_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GY21"/>
    <dbReference type="OMA" id="CTALQWM"/>
    <dbReference type="OrthoDB" id="79562at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061957">
        <property type="term" value="C:NVT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120113">
        <property type="term" value="P:cytoplasm to vacuole targeting by the NVT pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000009">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.320:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000004">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012777">
        <property type="entry name" value="LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049980">
        <property type="entry name" value="LTA4H_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02411">
        <property type="entry name" value="leuko_A4_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726:SF3">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00142">
        <property type="entry name" value="ZINC_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000324926" description="Leucine aminopeptidase 2">
        <location>
            <begin position="1"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="135"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="265"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P09960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q10740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="611" mass="69072" checksum="DCF0315477CB52A3" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYB8</accession>
    <name>Q2GYB8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxypeptidase D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_07036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224692.1">
        <property type="nucleotide sequence ID" value="XM_001224691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYB8"/>
    <dbReference type="FunCoup" id="Q2GYB8">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GYB8"/>
    <dbReference type="GeneID" id="4393230"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07036"/>
    <dbReference type="eggNOG" id="ENOG502RXXJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080487_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYB8"/>
    <dbReference type="OMA" id="LEYIHIC"/>
    <dbReference type="OrthoDB" id="373498at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18090">
        <property type="entry name" value="Arginine_MT_Sfm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="SFM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517:SF1">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="SFM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ85783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23042" checksum="9FD5D0C70346434B" modified="2006-03-21" version="1">MASGGKTYIVEHLDPELGTWSELEYLAIARESQETGAKFCLSSLPPAFKVPEDLAKIPAFKAETRGVEELYASDKSRVCLLDPAASSDLSPEDGDKFDAFLFGGILGDDPPRDRTSELRKKGFEGRRLGPVQMTTDTAVRVTRLVVQGKTPLKDIPYLDHPELKFNEHESTEMPFRYVKSEDGKPIMPEGMVDLIKKDSDKAIDDMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZD4</accession>
    <name>Q2GZD4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224326.1">
        <property type="nucleotide sequence ID" value="XM_001224325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZD4"/>
    <dbReference type="FunCoup" id="Q2GZD4">
        <property type="interactions" value="219"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GZD4"/>
    <dbReference type="GeneID" id="4392420"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05112"/>
    <dbReference type="eggNOG" id="KOG1618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030880_3_0_1"/>
    <dbReference type="InParanoid" id="Q2GZD4"/>
    <dbReference type="OMA" id="SWMETIH"/>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000069">
        <property type="entry name" value="HAD-superfamily subfamily IIA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF51">
        <property type="entry name" value="HYPOTHETICAL HAD-SUPERFAMILY HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="505" mass="55684" checksum="84435905A5ADC578" modified="2006-03-21" version="1">MSKPGFKEVDFGSSPKHSIHTPPDSPEKTTHPKDFPILPKKTDGQASTGHARKESRGKGLSLGSLEHNLTIPTSPTSHNTIERGGSRATPFGASLPIPKSKRQSRLSSVTYPAEAKDAISGVKPGVVQASREILASQVQDVFAHKVKAAKNMSFVFDIDGVLVHGDRLIPQGQKTLDMLNGNNQLGIKIPHIFLTNGSGKPELARTEQLSKILKNHIDTDQFIQSHTPMRALAEYYETVLVVGGEGYRCRDVAEEYGFKNIIVPNDIVAWDPSIAPYRVFTDEERASSRPRDFTQVNIDAILVFSDSRDYATDMQIIMDLLRSENGRLGTTAKDPVSQRIPIYFSQGDLLCPTEHPIPRMSQGAFRIGLEAMYKALTGVELERVVYGKPELATYKYADEVIASWMESLHGEERVPENIYMIGDNPASDIVGGNMYGWNTCLVRTGVFQGGDNDEENPANFGVFPNVWEAVTAACRKQLGDDFVFEWDARVVNPVLHDTATSAIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZL5</accession>
    <name>Q2GZL5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_05031</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224245.1">
        <property type="nucleotide sequence ID" value="XM_001224244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZL5"/>
    <dbReference type="STRING" id="306901.Q2GZL5"/>
    <dbReference type="GeneID" id="4391828"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05031"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_0_1"/>
    <dbReference type="InParanoid" id="Q2GZL5"/>
    <dbReference type="OMA" id="ARANDIY"/>
    <dbReference type="OrthoDB" id="5396311at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="52"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="505"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="505"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ88412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="561" mass="63517" checksum="ADAF9EB99A7ECA33" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZQ0</accession>
    <name>Q2GZQ0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ASTRA-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_04996</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the ASTRA complex involved in chromatin remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the ASTRA chromatin remodeling machinery complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ASA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224210.1">
        <property type="nucleotide sequence ID" value="XM_001224209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZQ0"/>
    <dbReference type="STRING" id="306901.Q2GZQ0"/>
    <dbReference type="GeneID" id="4391923"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04996"/>
    <dbReference type="eggNOG" id="KOG0322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041940_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GZQ0"/>
    <dbReference type="OMA" id="MQYETHE"/>
    <dbReference type="OrthoDB" id="7668193at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="193"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="346"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="195"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ88377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="426" mass="45108" checksum="425C14DD4B1A8A20" modified="2006-03-21" version="1">MATDGRPAQPKSILRGHKAPSARCNLLWKFTAEEESGLSKKLPLDPTSEARPQPWILYMLEVNTMNFCSFSHCPVSPGSGAASPEILVTVPNTLASEAIDIFHLPSQARQHTVKLGEKNGMVMALSLFHLGQTLTLVAGYENGAATVAQLGDHGNWAVRYHAKCHSQPVLSLDVSPNRDYFLTSSADAIIAKHPLPAPSPTIQPPQPNTTPSIPPPPPAEKPNNPPTTTTPPPPPPPPPPKSLLTAALSTTTSNTPPTPTPPINSNSTQTQPQTTTPLKTHNTRHAGQQSLRIRSDGRVFATAGWDARVRVYSARTLAEVAVLKWHGVGCYAAAFADVATVDGARGEGEGGVGNGEGDGDGDGEGEGEGEGEGSSQQQQGGQGKEVVAVPKLVDITVREKRERLAREGHWLAAGSKDGKVSLWDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZT2</accession>
    <name>Q2GZT2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_04964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224178.1">
        <property type="nucleotide sequence ID" value="XM_001224177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZT2"/>
    <dbReference type="GeneID" id="4392599"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04964"/>
    <dbReference type="HOGENOM" id="CLU_1586276_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZT2"/>
    <dbReference type="OrthoDB" id="10414926at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ88345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="168" mass="19023" checksum="1D87C21957B29FD6" modified="2006-03-21" version="1">MCFVPVIRYACCGSIMYALTGLPIIRPCRAAIMNGTINRLRDDSGWTGCLERHFEDTDSPTALKLWFPLLCHQCRAAQRFDVVRNNARKCSEFVEEALLRMEDRRIDIPSAIKAAYMDVILLLPEVGAYARLSVNGQNAEAERTQDYARAVTAYKRYLIAIGSLCRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZU0</accession>
    <name>Q2GZU0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224170.1">
        <property type="nucleotide sequence ID" value="XM_001224169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZU0"/>
    <dbReference type="GeneID" id="4393027"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04956"/>
    <dbReference type="eggNOG" id="ENOG502RW00">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_7_4_1"/>
    <dbReference type="InParanoid" id="Q2GZU0"/>
    <dbReference type="OMA" id="QSTIVEC"/>
    <dbReference type="OrthoDB" id="4558674at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
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    </dbReference>
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        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="77"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="262" mass="29947" checksum="F374BA7CD5287750" modified="2006-03-21" version="1">MHHWWRALESRCWDYVTISVVATKDTPSATTAGKITDWVLPGDKSGEFKRQQSSFRNWISSEPGAQFPPEKGRYHLYANRTLIARKLKGLEDVISFSAVHWHMGSKGWRFPTAEDTDAAGENVIPDPIPGHESFTHLRDLYFSVNPSYEGRFTVPVLYDIKTQTIVNNESSEILRMLGTEFNSLIDEKYRQIEFYPEALRAQIDEAHEWQYDKINNGVYKSGFATTQEAYERNVIALFEALDRAEEHLKKTAAEGPTGSARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZZ9</accession>
    <name>Q2GZZ9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Signaling mucin MSB2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_04897</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224111.1">
        <property type="nucleotide sequence ID" value="XM_001224110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZZ9"/>
    <dbReference type="STRING" id="306901.Q2GZZ9"/>
    <dbReference type="GeneID" id="4392329"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04897"/>
    <dbReference type="eggNOG" id="ENOG502QW7T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008998_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GZZ9"/>
    <dbReference type="OMA" id="SGRNQMI"/>
    <dbReference type="OrthoDB" id="3366093at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005034">
        <property type="term" value="F:osmosensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006972">
        <property type="term" value="P:hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039295">
        <property type="entry name" value="MSB2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35778">
        <property type="entry name" value="SIGNALING MUCIN HKR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35778:SF1">
        <property type="entry name" value="SIGNALING MUCIN HKR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208794" description="Signaling mucin MSB2" evidence="3">
        <location>
            <begin position="20"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="657"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ88278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="764" mass="77011" checksum="BD034E60FC2D229F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0D6</accession>
    <name>Q2H0D6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223974.1">
        <property type="nucleotide sequence ID" value="XM_001223973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0D6"/>
    <dbReference type="GeneID" id="4391997"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04760"/>
    <dbReference type="HOGENOM" id="CLU_3335508_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H0D6"/>
    <dbReference type="OrthoDB" id="415315at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="38" mass="4259" checksum="BFAE27D3EF4695C0" modified="2006-03-21" version="1">MLERGVQPHLAYLVAGFIGDLAASTVGWWPRRHNNMPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0P5</accession>
    <name>Q2H0P5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001223864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0P5"/>
    <dbReference type="GeneID" id="4392120"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04651"/>
    <dbReference type="HOGENOM" id="CLU_2589544_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H0P5"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="80" mass="8588" checksum="A45D5EDC77CA5F67" modified="2006-03-21" version="1">MAGVFSGISAQQPAESNIGITHRAFVVLGRLLLSAVSFGDLLPDRCPGRPLKIPATQPQPGRGSPWHSATRRQPDPSLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1K8</accession>
    <name>Q2H1K8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine amidotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223552.1">
        <property type="nucleotide sequence ID" value="XM_001223551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1K8"/>
    <dbReference type="FunCoup" id="Q2H1K8">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H1K8"/>
    <dbReference type="GeneID" id="4391699"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04338"/>
    <dbReference type="eggNOG" id="KOG3179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054974_0_2_1"/>
    <dbReference type="InParanoid" id="Q2H1K8"/>
    <dbReference type="OMA" id="PWIQTLK"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="52"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="245" mass="27315" checksum="102958FA7ACBE56D" modified="2006-03-21" version="1">MPLRLAILEADTPVPAANERYGGYFGVFKHLFTRAVAPAPLESELILTGHNVVHNPSTAYPNLEDVDAILISGSKHNAFEDDEWILTLVEFVRKALLHDRVKVVGICFGHQIVARALGALVARSDQGWEISVVETRLTEKGKEVFGKERETLQMHRDQVFGVPPGAEVLASTDKCPNHGFLIPGRAITVQGHPEFTEDIMGEILELRHESGLFVDDLYRSGKERNGDHHDGIFMAQVFLKFLQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1Z8</accession>
    <name>Q2H1Z8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223412.1">
        <property type="nucleotide sequence ID" value="XM_001223411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1Z8"/>
    <dbReference type="STRING" id="306901.Q2H1Z8"/>
    <dbReference type="GeneID" id="4392972"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04198"/>
    <dbReference type="eggNOG" id="KOG2919">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022731_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H1Z8"/>
    <dbReference type="OMA" id="IRTWILP"/>
    <dbReference type="OrthoDB" id="239865at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051150">
        <property type="entry name" value="SWT21/TCAB1_mRNA_Telomere"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211:SF0">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="50355" checksum="14D62B644EE02369" modified="2006-03-21" version="1">MEPPSVNLKAITGNPNGSIPPKHKAHSHDAFFKSVQWSADGTTLFTSSFSSRICTFVLPETLLQPRESPVELIAHSTLALPEPSSAIAPCPYFALEHPSTQTLLTASTDHPIHLHHAFPPSPSPTSPSPADDSTHDTPSPPPPPPPPPPTRTQPPPLASFRLIKHETEAYLPIASLTWPAPGTHFIAGTTNRIALFDLSRPDALDPNPLLSIPTIPSTRHLAKGGGVGMRGVVSALAAQPMSVAGVDGGDGGGGGGWGLLAAGTRTRNLGLYDLVRSGECVATWSAAGAAREAGIGGRGVMQTAWSPCGRYLVVNERGATGLLVYDLRGTHRLLGTLEGRDGTTNQRLSCDVFSGTESMGGFEVWAGTKNGGVVVWEGVGNQEGAVQPSWDWKAHGSAVGATAMHMSGSVVATCSGAWTFVDRDEDESSDSSDCSDAGAGATRRGNSKSKIVVEETSLKVWSLGPGNSPQVERDNDVGGDAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H292</accession>
    <name>Q2H292_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Pisatin demethylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_04104</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223318.1">
        <property type="nucleotide sequence ID" value="XM_001223317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H292"/>
    <dbReference type="STRING" id="306901.Q2H292"/>
    <dbReference type="GeneID" id="4392069"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04104"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="InParanoid" id="Q2H292"/>
    <dbReference type="OMA" id="WLHYFAF"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000050">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ87485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="58936" checksum="308AD0AD810BF930" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2T5</accession>
    <name>Q2H2T5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_03911</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TIM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223125.1">
        <property type="nucleotide sequence ID" value="XM_001223124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2T5"/>
    <dbReference type="STRING" id="306901.Q2H2T5"/>
    <dbReference type="GeneID" id="4392175"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03911"/>
    <dbReference type="eggNOG" id="KOG4836">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133360_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2T5"/>
    <dbReference type="OrthoDB" id="436405at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="77" xmlns="https://uniprot.org/uniprot">
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        </lineage>
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            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
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        <property type="protein sequence ID" value="EAQ90096.1"/>
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    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06715"/>
    <dbReference type="eggNOG" id="KOG1607">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_028277_2_2_1"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="9">
        <location>
            <begin position="332"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="161"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="612"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="630"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ90096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="647" mass="73869" checksum="E1ED975AD5B4EA7E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H419</accession>
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        <recommendedName>
            <fullName evidence="6">SMP-LTD domain-containing protein</fullName>
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    </protein>
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        <name evidence="4" type="ORF">CHGG_06596</name>
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    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="AlphaFoldDB" id="Q2H419"/>
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        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H419"/>
    <dbReference type="GeneID" id="4390078"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06596"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_006760_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H419"/>
    <dbReference type="OMA" id="AKKWSWS"/>
    <dbReference type="OrthoDB" id="26740at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SMP_TEX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF19">
        <property type="entry name" value="NUCLEUS-VACUOLE JUNCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15413">
        <property type="entry name" value="PH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="471"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="730"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="562"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="580"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="621"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="634"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="732"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="762"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="797"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="835"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ89977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="936" mass="101652" checksum="55884759FD6C6B92" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4Z6</accession>
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        <recommendedName>
            <fullName evidence="13">SWI/SNF family DNA-dependent ATPase Ris1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_06269</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001222363.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="4391318"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06269"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H4Z6"/>
    <dbReference type="OMA" id="KWMTDME"/>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
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    </dbReference>
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        <location>
            <begin position="508"/>
            <end position="647"/>
        </location>
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        <location>
            <begin position="806"/>
            <end position="858"/>
        </location>
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        <location>
            <begin position="1031"/>
            <end position="1193"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
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        <location>
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            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
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        <location>
            <begin position="237"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="880"/>
            <end position="995"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
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        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
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        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
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        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
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        <location>
            <begin position="932"/>
            <end position="948"/>
        </location>
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        </location>
    </feature>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1203" mass="132682" checksum="475AB3C34EA74B14" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
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            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="102" mass="11143" checksum="2B9C7E8BD58287F6" modified="2006-03-21" version="1">MASGAYDPFRPKGQASQDPSAPSGSGPDRFGVMKEELNGAIRAASHNIESVRDRGERLDNLQDKSAGLNAAAQDFHGRAGKVRRQMWWKVSRFATPRELGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5F9</accession>
    <name>Q2H5F9_CHAGB</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
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            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="4390701"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06106"/>
    <dbReference type="eggNOG" id="ENOG502RR30">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196968_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5F9"/>
    <dbReference type="OrthoDB" id="5170782at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="86" mass="9946" checksum="B09417D7BBD42B86" modified="2006-03-21" version="1">MGNSYQRKPNTKYKLPIQWTDEIRHKHCGAVDIGRDGKPNKAHRCKACLAVKARESKLRNGPDDIKLGREEKMELKFGDVQQKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5G8</accession>
    <name>Q2H5G8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06097"/>
    <dbReference type="eggNOG" id="ENOG502SA8A">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060781_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H5G8"/>
    <dbReference type="OMA" id="PEMQPEM"/>
    <dbReference type="OrthoDB" id="4505928at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070:SF1">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="27631" checksum="F7A645A250C4BE9B" modified="2006-03-21" version="1">MTPREKKQQDPSTDPSSAAARIRNNQRRSRARHREFVDELKAKVREYERQGVQATLDMRQAARKVALENSRLRSLLASRGVTDEEISHYLAQFEDRASVGLPTAAPTPQTDASPRLPVGSDSGLLSSDRNVPDVEPASGLNTLAVAADTSARQTCCGPTTQCTPDEGRGVQSAAAEVPPQGHPASPSPSPNKPNTTTTSHLEMSCTAAAHIMANMYRHGNSELAREALGCSGPEECYVKNTLVFQLLDRAERDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5T1</accession>
    <name>Q2H5T1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222079.1">
        <property type="nucleotide sequence ID" value="XM_001222078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5T1"/>
    <dbReference type="GeneID" id="4391044"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05984"/>
    <dbReference type="eggNOG" id="ENOG502SHAW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014025_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H5T1"/>
    <dbReference type="OMA" id="CHYREPQ"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="730" mass="79785" checksum="793DE4198AE40C73" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5T5</accession>
    <name>Q2H5T5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_05980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222075.1">
        <property type="nucleotide sequence ID" value="XM_001222074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5T5"/>
    <dbReference type="GeneID" id="4391399"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05980"/>
    <dbReference type="HOGENOM" id="CLU_1677664_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5T5"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="157" mass="16386" checksum="40C89EBC98596DE5" modified="2006-03-21" version="1">MTRYSNGFVQVLDFVKVLGPALPQTTMPQCTTVPCSACPGTPVHKAEGSSALVCRPTASRVSLPSSAGVDIVRVARRLFETVVNSNSYAAALFDSSDSKTTPPMESAGFVEMGQAEKEALIHAVPLDHGGGLDDGDGDHAFFVPVHTPASSARGIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H616</accession>
    <name>Q2H616_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prefoldin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221994.1">
        <property type="nucleotide sequence ID" value="XM_001221993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H616"/>
    <dbReference type="FunCoup" id="Q2H616">
        <property type="interactions" value="902"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H616"/>
    <dbReference type="GeneID" id="4390154"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05899"/>
    <dbReference type="eggNOG" id="KOG3048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091867_0_2_1"/>
    <dbReference type="InParanoid" id="Q2H616"/>
    <dbReference type="OMA" id="QAKFKAC"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000004">
        <property type="entry name" value="Probable prefoldin subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00308">
        <property type="entry name" value="PfdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="17129" checksum="F19112AA83CBC435" modified="2006-03-21" version="1">MASRGGQQQGEAVDLGTLSAQQLSAVKKQLDGEVEHLSSSYGQLAAAQAKFKECLRVVKSGSSSFDKEKSILVPLTNSLYVKGRLADPDRVLVDVGTGFYVEKTTESASEFYDAKVKELAGNIQGLEGIVQAKTNNLRVVEEVLRQKVLAQGGPGAAGQASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H662</accession>
    <name>Q2H662_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase 17.8 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221948.1">
        <property type="nucleotide sequence ID" value="XM_001221947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H662"/>
    <dbReference type="STRING" id="306901.Q2H662"/>
    <dbReference type="GeneID" id="4390942"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05853"/>
    <dbReference type="eggNOG" id="ENOG502S7GA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095735_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H662"/>
    <dbReference type="OMA" id="RNIQAGH"/>
    <dbReference type="OrthoDB" id="2120038at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034444">
        <property type="entry name" value="Nuo17.8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42100">
        <property type="entry name" value="OXIDOREDUCTASE 178 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42100:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 178 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="19578" checksum="8108E4FFC4B3B140" modified="2006-03-21" version="1">MSALRQRAAQLARQARTARPIAAQNTRSYASSHGHAAPHTVEESLGPGFFIAMGTFVGTVFVYQISRPGENGELSALHKWVQKVSNYGTEWETKNHLMSAALQQAARDKHLLYTADRSTYHELSYPEVFTHGSPFNVPAGHYPNINKVVAHYQKQHHEDEARKAKKLAAAAAASAASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6F8</accession>
    <name>Q2H6F8_CHAGB</name>
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        <recommendedName>
            <fullName evidence="8">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">CHGG_05757</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001221851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6F8"/>
    <dbReference type="STRING" id="306901.Q2H6F8"/>
    <dbReference type="GeneID" id="4391058"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05757"/>
    <dbReference type="eggNOG" id="ENOG502QTY2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009538_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6F8"/>
    <dbReference type="OMA" id="RQDFGNT"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000273">
        <property type="entry name" value="Leucine Rich Repeat domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 11-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="291"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="662"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="722"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="815"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="411"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="667"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="722"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ89138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="856" mass="93773" checksum="25CC0BB3ED65B290" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6Q2</accession>
    <name>Q2H6Q2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_05663</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221758.1">
        <property type="nucleotide sequence ID" value="XM_001221757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6Q2"/>
    <dbReference type="GeneID" id="4390784"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05663"/>
    <dbReference type="eggNOG" id="ENOG502SIGA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016509_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6Q2"/>
    <dbReference type="OMA" id="LTVICHQ"/>
    <dbReference type="OrthoDB" id="2283488at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR ASQA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="196"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ89044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="760" mass="83351" checksum="A471AE32696FEF70" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7G1</accession>
    <name>Q2H7G1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_05404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221499.1">
        <property type="nucleotide sequence ID" value="XM_001221498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7G1"/>
    <dbReference type="GeneID" id="4391214"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05404"/>
    <dbReference type="HOGENOM" id="CLU_3014020_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7G1"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ88785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="56" mass="5829" checksum="939F6FE45100AA5F" modified="2006-03-21" version="1">MSLQDQGEARGSGNKTDRDTDIIINGLVAPLSLPFGTQSPWASPWDLSNLAAASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8I3</accession>
    <name>Q2H8I3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl transferase family 25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_03471</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229987.1">
        <property type="nucleotide sequence ID" value="XM_001229986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8I3"/>
    <dbReference type="GeneID" id="4389462"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03471"/>
    <dbReference type="eggNOG" id="ENOG502SHN6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032992_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H8I3"/>
    <dbReference type="OMA" id="KEERYVD"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF53">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 25" evidence="5">
        <location>
            <begin position="37"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="150"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ91536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="380" mass="42233" checksum="44989CB7BF902B57" modified="2006-03-21" version="1">MGLFWGPPHGRHPKYHPGFFFVCNYFIRGIDPGPQFEKIFVVGLPSRTDRRDGMVLQAALSNMDIEFIDGVAGADVPDKAIPMNKGQKRLRDASIGSWRAHMNAIREVVHRNLSSALILEDDVDWDVRVRSQLADFALAAHALTQPVLGSPPSSPTYMDPTYPHPVPDSSPDSLPDFPFSALPPTTPPSHSPYGDSWDVLWIGHCGMHFPFARHPHVPKSRIIRADDATVAPPKNLWTFNIPFTLKRDYPPHTRAYHHVQEGVCTLGYAVSRRGAQKLLYEVGLKGVDAAFDLLLRYYCEGEKGRAPGRQCLTTQPGLFQHHRPAGPASAMSDIGDHGDGWKESSMTDMVRWSVRLNAEVLLEGGTEFRDQFPGEEGGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8P9</accession>
    <name>Q2H8P9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229921.1">
        <property type="nucleotide sequence ID" value="XM_001229920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8P9"/>
    <dbReference type="GeneID" id="4389788"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03405"/>
    <dbReference type="eggNOG" id="ENOG502R9JV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_305871_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8P9"/>
    <dbReference type="OrthoDB" id="4589943at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209077" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="727"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="480"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="727"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="969" mass="99697" checksum="18657BCFFF913DA8" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8T7</accession>
    <name>Q2H8T7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mei2-like C-terminal RNA recognition motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229883.1">
        <property type="nucleotide sequence ID" value="XM_001229882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8T7"/>
    <dbReference type="STRING" id="306901.Q2H8T7"/>
    <dbReference type="GeneID" id="4388519"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03367"/>
    <dbReference type="eggNOG" id="KOG4660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019467_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8T7"/>
    <dbReference type="OMA" id="NGPMPEL"/>
    <dbReference type="OrthoDB" id="417481at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007201">
        <property type="entry name" value="Mei2-like_Rrm_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04059">
        <property type="entry name" value="RRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mei2-like C-terminal RNA recognition motif" evidence="2">
        <location>
            <begin position="488"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="709" mass="78132" checksum="570F7AD4B578667D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9I5</accession>
    <name>Q2H9I5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_03119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229635.1">
        <property type="nucleotide sequence ID" value="XM_001229634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9I5"/>
    <dbReference type="STRING" id="306901.Q2H9I5"/>
    <dbReference type="GeneID" id="4388443"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03119"/>
    <dbReference type="eggNOG" id="ENOG502QQTI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007201_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H9I5"/>
    <dbReference type="OMA" id="DWHPRNL"/>
    <dbReference type="OrthoDB" id="2262349at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000012">
        <property type="entry name" value="C6 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="78"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="591"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="914"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="604"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ91184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="977" mass="107741" checksum="11A19E3C1DD06815" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9J0</accession>
    <name>Q2H9J0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Guanine nucleotide-binding protein beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_03114</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229630.1">
        <property type="nucleotide sequence ID" value="XM_001229629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9J0"/>
    <dbReference type="FunCoup" id="Q2H9J0">
        <property type="interactions" value="385"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H9J0"/>
    <dbReference type="GeneID" id="4388468"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03114"/>
    <dbReference type="eggNOG" id="KOG0286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_34_1"/>
    <dbReference type="InParanoid" id="Q2H9J0"/>
    <dbReference type="OMA" id="PLDSQWV"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000020">
        <property type="entry name" value="Guanine nucleotide-binding protein beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="143"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="184"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="227"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="278"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="313"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ91179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="346" mass="38296" checksum="C9A3089E7229D498" modified="2006-03-21" version="1">MQGRIQQARREAETLKDRIKRKKEELADTTLRAVAAQAHEPIPKSQLMRTKRTLKGHLAKIYAMHWSTDRRHLVSASQDGKLIIWDAYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYNLNQSRDGPTRVARELSGHAGYLSCCRFINDRSILTSSGDMTCMKWDIETGTKVMEFADHLGDVMSISLNPTNQNTFISGACDAFAKLWDIRAGKAVQTFAGHESDINAIQFFPDGHSFVTGSDDATCRLFDIRADRELNFYGSETILCGITSVATSVSGRLLFAGYDDFECKVWDITRGEKVGSLVGHENRVSCLGVSNDGISLCTGSWDAVLKVWAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HA46</accession>
    <name>Q2HA46_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229424.1">
        <property type="nucleotide sequence ID" value="XM_001229423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HA46"/>
    <dbReference type="GeneID" id="4389036"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02908"/>
    <dbReference type="eggNOG" id="ENOG502RIYF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_553413_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HA46"/>
    <dbReference type="OMA" id="WENAVLI"/>
    <dbReference type="OrthoDB" id="4581875at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="496" mass="54142" checksum="6012213C40D87ABA" modified="2006-03-21" version="1">MEESAGLELFAQYLQGDDDVDSLFGGGDQDGELGSLFTEPAAEVEPSTPGPDCEPELPSSQQRPHEAANPPAQLDSAADQPPTRSAQRPALSLPQLSLPAVPDPLAASLLHQHGHTSGDLVVSTQVSASASGSGPAAPSLEELDDAALEAELSGLWEADASGEQPVNAQTEDQESDPIQEEFQILTTQIPGFRYANSNTNAFIRLPRRIDLNLKHAEELVEVLYGYLELNAAEGKRLMADMKKLLKEPPLSALVAQPASRSTETKRILVRMAFYMLISQEWGRTWFGEDHETAASRKYLWPRDSSILLAGFVTILYRVYTNRKQVYQGIMRAQSRLREANPSPPPSPAPSAPPADFSQSPSPVPASQSFFEVIAKDASAGKKRKHSEAVLGINQVHYDVEVPANARLKYHIYVKDKNDGADLAPTSTYRHTDYMISRGAFSSLKAAFEATGQDPVYIIHTPFGRRAVTSEEEWENAVLIIYNARRSGGVVEVDILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HA64</accession>
    <name>Q2HA64_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_02890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229406.1">
        <property type="nucleotide sequence ID" value="XM_001229405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HA64"/>
    <dbReference type="GeneID" id="4389513"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02890"/>
    <dbReference type="eggNOG" id="ENOG502S9FS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021861_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HA64"/>
    <dbReference type="OMA" id="QWPSMLT"/>
    <dbReference type="OrthoDB" id="9909311at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAF9</accession>
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        </submittedName>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
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                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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    </dbReference>
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        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
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        <location>
            <begin position="28"/>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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        <location>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="360" mass="37885" checksum="F819185574C2FADC" modified="2006-03-21" version="1">MAPRPSLLGISSALWLLFASFAHDAAAHPFPKDDLHAAGYGYLMPRQCNQYCGYNNMFCCEEGTQCYTANGIAGCSSDAGGGWARYTTTWTLTQTFTKTYNSFVPAATAPPGTGDCVPPEGSGQIACGNICCASWQYCAYKGHGTATTTNTDTAAGAATSTGAVNPGGTAGGLSGGAIAGIVIGTIAGVALLLLICACCVVRGLWHGLLALLGIGGRKKKTETVIEEERYERRGSSHTHRDNHGSWYGGRPASASARKEKSKGAGLLGMGAALGTLALLLGLRRDHKKKAAPAKTRSDVASSYWSDSYTATSPSSRSSDRRTRHSRNSRAPSRVTRTTHTRTRVSRSRGPSVRSQRSPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAI2</accession>
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        </recommendedName>
        <alternativeName>
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        </alternativeName>
    </protein>
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        <name evidence="8" type="ORF">CHGG_02772</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Sordariales</taxon>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division.</text>
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        <subcellularLocation>
            <location evidence="5">Vacuole membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
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        <text evidence="1 5">Belongs to the NPR3 family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="HTH_NPRL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005365">
        <property type="entry name" value="Npr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153">
        <property type="entry name" value="CGTHBA PROTEIN -14 GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153:SF5">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24064">
        <property type="entry name" value="HTH_NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03666">
        <property type="entry name" value="NPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GATOR1 complex protein NPRL3 C-terminal HTH" evidence="7">
        <location>
            <begin position="853"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
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            <end position="218"/>
        </location>
    </feature>
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        <location>
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            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="796"/>
            <end position="816"/>
        </location>
    </feature>
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        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
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        <location>
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            <end position="218"/>
        </location>
    </feature>
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        <location>
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            <end position="628"/>
        </location>
    </feature>
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        <location>
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            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="643"/>
            <end position="657"/>
        </location>
    </feature>
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        <location>
            <begin position="658"/>
            <end position="698"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00010546"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00017880"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ90837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="904" mass="98843" checksum="D628768D6681A6A7" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAR4</accession>
    <name>Q2HAR4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
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            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
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    <comment type="function">
        <text evidence="6">Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a di-trans,poly-cis-dolichyl diphosphate + H2O = a di-trans,poly-cis-dolichyl phosphate + phosphate + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="EC" id="3.6.1.43"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the dolichyldiphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.43" evidence="6"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229036.1">
        <property type="nucleotide sequence ID" value="XM_001229035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HB84"/>
    <dbReference type="FunCoup" id="Q2HB84">
        <property type="interactions" value="315"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HB84"/>
    <dbReference type="GeneID" id="4389221"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02520"/>
    <dbReference type="eggNOG" id="KOG3146">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074922_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HB84"/>
    <dbReference type="OMA" id="VYATLIW"/>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047874">
        <property type="term" value="F:dolichyldiphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03382">
        <property type="entry name" value="PAP2_dolichyldiphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039667">
        <property type="entry name" value="Dolichyldiphosphatase_PAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF1">
        <property type="entry name" value="DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="54"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ90585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="275" mass="30228" checksum="F0E3180EF66A6491" modified="2006-03-21" version="1">MADDITPLASLSITHVYYDPTDPLSTLAALLSLLPQGLCVVYATLLWSTREAEVLLLFAGQLACEAVNLVLKRLIKEERPPHRLMGPAAGRGYGMPSSHAQFVFFWAVAAGLFLCVRHRPRPLKAVSSNGAGVGDVHRAYRVGGLSAAAASIEAYSHSHWTLGQRVVVSGGGLFVAGLVAWSRVYLGYHSVRQVLAGCAAGAGCAVAWFAVTYLMREMGLVAWALDMPLARWLRMRDLVVVEDLCQAGWEKWEERRRMVLEKDRAREKAKARKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBA1</accession>
    <name>Q2HBA1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_02503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229019.1">
        <property type="nucleotide sequence ID" value="XM_001229018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBA1"/>
    <dbReference type="GeneID" id="4389711"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02503"/>
    <dbReference type="eggNOG" id="ENOG502SQ74">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038389_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HBA1"/>
    <dbReference type="OMA" id="YSHIPFW"/>
    <dbReference type="OrthoDB" id="5383784at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ90568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="550" mass="59922" checksum="D4371BBF0A454197" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBW9</accession>
    <name>Q2HBW9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228801.1">
        <property type="nucleotide sequence ID" value="XM_001228800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBW9"/>
    <dbReference type="STRING" id="306901.Q2HBW9"/>
    <dbReference type="GeneID" id="4388588"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02285"/>
    <dbReference type="eggNOG" id="KOG4442">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029124_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HBW9"/>
    <dbReference type="OMA" id="IWRQLHS"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="349"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="441" mass="48847" checksum="456BF12D71BFDFD7" modified="2006-03-21" version="1">MKVDNDAVATLREASLDKFVGGIWEQIYGGIDLDPQSILEQWQAAASAASATDAPPQTIREHPAALNLSTSGLLPATAFPADVSGSFNQSNILCRKVTQASRTFRSIEVVVQARWIEHFEAYVKTLAASNPSTSVTKHRKAALLEACQDFSWTDKDLRNRMRIWSGYKEIKDAGGWAALVFAGMGIYRFCKYRVGFDADSMQTLQTLRPRLEVAADTLHPNWRRLLAVVGEPTERRFTGHPHDWVVFPCGAAVSDPIPLRSTYLGRDPLFSFEHLDESIVDVHAWGGDDPRYVPPLPPTTTTTTTAATYPRPTSTYTCRTCHQVQSDDPKLNNCFCFPSLFGSGPRAASPVQIFRTSNGRNNGLQALVPFERGAAVGEFVGLVTRGLQDVDVFNGAAGSRPYQIWQGRQGNYTRFVNHSCRPNAQFQSFVWMGAERIVLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HC94</accession>
    <name>Q2HC94_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyltransferase MbtK/IucB-like conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_02160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lysine N-acyltransferase MbtK family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228676.1">
        <property type="nucleotide sequence ID" value="XM_001228675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HC94"/>
    <dbReference type="STRING" id="306901.Q2HC94"/>
    <dbReference type="GeneID" id="4389874"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02160"/>
    <dbReference type="eggNOG" id="ENOG502RZMI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027095_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HC94"/>
    <dbReference type="OMA" id="FPHKQSW"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438:SF1">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13523">
        <property type="entry name" value="Acetyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="504" mass="56200" checksum="D47518E6BD9D63D8" modified="2006-03-21" version="1">MGPQTIYLPDGQRFNVTPVFAGLFFKSTELSSHHNAFPIGWTIVIHTEDGDGDEAASSAVSPSRGVAEDIPSPEKTSHLRTFKRPTLQNDSLFISSISNPSNAEFKPAASPTRQIAMMLWVTLYWYFHQPPPSTILTTEASQLTPDAGKPRGEWRVRIKRDGMLRGRNVIPKLERMGLIACLNSAVGTALVDTDEVWANMFVTRTMFWQIPGRLFLFTLQPVGSRNPRSSYPGSPISSRPGSPLPGESSTAIHPQLAIAEAGDLPGAAPPTSLTSMPSFPISPFFSASHLPTYYPPPPMQYTITNHVRHPLRPKPPRMGEVFYTRFVPSAGQYLSLRVASISTKPVPYMGPVGPNPPIPTPQQQSRLLSMPDSALLESWHANPRVSRFWGEYAAGFLVAALQSRHSFPVIGLWDGVPFGYFELYWVKEDLLGRYAGSSAVDDWDRGCHVLIGEEWARGRVQSWLSSLVHWMFCADYRTMSICLEPRVDNTRHMETRCEPRDRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HD46</accession>
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        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">CHGG_01858</name>
    </gene>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF7611"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF7614"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF24587">
        <property type="entry name" value="DUF7612"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF7614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7611" evidence="2">
        <location>
            <begin position="537"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7612" evidence="3">
        <location>
            <begin position="692"/>
            <end position="824"/>
        </location>
    </feature>
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        <location>
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            <end position="979"/>
        </location>
    </feature>
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        <location>
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            <end position="1120"/>
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    </feature>
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            <end position="41"/>
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            <end position="158"/>
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            <end position="354"/>
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            <dbReference type="Pfam" id="PF24586"/>
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        <source>
            <dbReference type="Pfam" id="PF24588"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24589"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ93623.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1135" mass="125456" checksum="E873F116AF60DD39" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HE44</accession>
    <name>Q2HE44_CHAGB</name>
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        <recommendedName>
            <fullName evidence="2 9">Histone deacetylase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_01510</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 9"/>
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        <property type="protein sequence ID" value="EAQ93275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001220730.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="4388153"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01510"/>
    <dbReference type="eggNOG" id="KOG1342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_7_4_1"/>
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    <dbReference type="OMA" id="GWLRAFH"/>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:nuclear periphery"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:Rpd3L-Expanded complex"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:Set3 complex"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HISTONE DEACETYLASE 3"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Hist_deacetyl"/>
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    </dbReference>
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        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="83"/>
            <end position="382"/>
        </location>
    </feature>
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        <location>
            <begin position="472"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="472"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="200"/>
        </location>
    </feature>
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        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="329"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:60240"/>
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        <location>
            <position position="368"/>
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        <ligand>
            <name>substrate</name>
        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
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    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ93275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="496" mass="55718" checksum="BA310DF778A5898E" modified="2006-03-21" version="1">MDASAYRYRPPKPNYLPHHIETDGPVVEEYALPLGKADDRENAIFFNKMKFAAQEYGIVRPKGYTVSYHATPEMEKHHFGQTHPMKPWRLTLTKSLVTSYGMPFAMDNYLTREATYEELNSFHSSEYLDYLATAAPEDQPQDIEEPGKDVKFNLGGSDCPLFHGLYNYCSMSAGCSLDAARKITSKQSDIAIAWGGGLHHAKRKEASGFCYINDIVLAILQLLRTHPRVLYIDIDVHHGDGVEEAFFSTDRVMTVSFHKYHPETFFPGTGALEDNGPKSEHNPGAHHAINVPLQDGITDEQYETLFQSIIGSINERYRPSAIALQCGADSLAGDRLGRFNLRVQGHGACVRYCKSLGLPMIVFGGGGYTPRNVARAWAYETAIAIGADTRIPETIPDHAPWREHFIHDTLFPSLEQSLNEPRHNRNSDKRLREIITHVQEQLRFVAQAPSVQSSIIPPDLGPIRDDVEARLKEENDEKNGGLRRIQEEGLGQDMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HE76</accession>
    <name>Q2HE76_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Short-chain dehydrogenase/reductase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_01478</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220699.1">
        <property type="nucleotide sequence ID" value="XM_001220698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HE76"/>
    <dbReference type="GeneID" id="4386189"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01478"/>
    <dbReference type="eggNOG" id="KOG1201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_5_0_1"/>
    <dbReference type="InParanoid" id="Q2HE76"/>
    <dbReference type="OMA" id="HYWLAQE"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000131">
        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ93243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="365" mass="40936" checksum="3762B788E399FA5D" modified="2006-03-21" version="1">MPMHNGFLPREGFKGDTVLKIIRDTALNPQLVLPLLLLTKYTKKGQDWAILHPLAYSRLKKLLVFGLVRWINNYFSRKVLNNWVDDKYDWSKEIVVVTGGAGERKAPNVHYFKCDLTSRKTLSTVAREVRLAVGDPTVLINNAGVVQGRTILESSERDIRFTFDVNTFAHYWTTQEFLPAMVRANHGMVVTVASVAAWVTVPNMVDYAASKAAAHAFHEGLTAELATRYGAPRVRTVLVNQGYTTTPLFRGYRNDSPFLMPALYPATVAEAIVRQVLKGERNQLILPGFAGTLPVLAGMPHWYQTRLRAKNQTIMKAFAGRKVVEDVERFYEEKEEAENRGKRVTVEEEAEEGVGAGASTVLVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HE96</accession>
    <name>Q2HE96_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220679.1">
        <property type="nucleotide sequence ID" value="XM_001220678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HE96"/>
    <dbReference type="STRING" id="306901.Q2HE96"/>
    <dbReference type="GeneID" id="4386217"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01458"/>
    <dbReference type="eggNOG" id="ENOG502RFD2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044229_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HE96"/>
    <dbReference type="OMA" id="WGLVCAI"/>
    <dbReference type="OrthoDB" id="5420724at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="55799" checksum="B761D4B521D6DFF7" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEA6</accession>
    <name>Q2HEA6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220669.1">
        <property type="nucleotide sequence ID" value="XM_001220668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEA6"/>
    <dbReference type="STRING" id="306901.Q2HEA6"/>
    <dbReference type="GeneID" id="4387712"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01448"/>
    <dbReference type="eggNOG" id="ENOG502RZYU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073360_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HEA6"/>
    <dbReference type="OMA" id="GLEAYQM"/>
    <dbReference type="OrthoDB" id="2141514at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209166" evidence="1">
        <location>
            <begin position="17"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="276" mass="28711" checksum="16BB2A3705374381" modified="2006-03-21" version="1">MKTTLSALALVALSSATPVSLKERQGQSTGDGPFAPAGYYTSNALQGHTFYAPKEIPEGTKLPVMLWGNGGCSADATGQAPFLTQLASHGVLVIASGTPGGQGSTTADVMKQSIDFISTNAGQGDFASVDASRITAAGWSCGGVEAYAQIWDDRVQSVGIWSSGLLTNYTAAENFRKPVFFFLGGQSDIAFGNGERDYNAMPAGVPKWKGNLDVGHGGTYTDFNGGKFGVIGGHWVEWTMRGNSSASAYLTGDGAKADGWQVVSADLDKFSVEPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEF9</accession>
    <name>Q2HEF9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220616.1">
        <property type="nucleotide sequence ID" value="XM_001220615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEF9"/>
    <dbReference type="STRING" id="306901.Q2HEF9"/>
    <dbReference type="GeneID" id="4387692"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01395"/>
    <dbReference type="eggNOG" id="KOG0834">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1111259_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HEF9"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="250" mass="27470" checksum="3F6DD01F960D77C1" modified="2006-03-21" version="1">MSSVDRYRPVREGYQPPSLPPKPMPAAIDRLSKSPSRRRDVPPAVPSPPAYSSRTSPPRPHSRRSAHSPGQSSPHRAPQPRPNQWFFTADEVASTPSVAEGLPLVEDRLRRAKGVNFIYQAGILLELPQITLWVAGVFFHRFYMRYSMMEEKGGIHHYAAAVGGESNSNGAESALQASNRGDSDAALKVAANDLDTHEGSNLALNGSDLDGGGLVSPQVRRRSEDPEGWEEREAKRRRLDDEDEGEIKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEM0</accession>
    <name>Q2HEM0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220555.1">
        <property type="nucleotide sequence ID" value="XM_001220554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEM0"/>
    <dbReference type="GeneID" id="4386430"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01334"/>
    <dbReference type="eggNOG" id="ENOG502SZB5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_644051_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HEM0"/>
    <dbReference type="OrthoDB" id="4368687at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="46405" checksum="716AADEADE38FB25" modified="2006-03-21" version="1">MAPIDYSKWDNIDTDSEPEVSSTQVPAPKATQPPAPTTPTVAVVHIHSDGNATIAVNGFTSGRQELPQAGLPQGSPLSPVLFLFFNADLRSRTALESKLSSTKALDWEKRSAPVMDYAANVWMHACGEKALSWLNRAQKIGALAITGAFRTAATAVVEAEASIYPVRERHVQAAASLWINIHTLPGTHPLAMKKVRTTVRFVSPLQKIARVAEGVRVDRMETIQEYAVPPWVPRLRPTLEADRGKGGRDGQQNLGNRDRNQLIPEIDFALGSDAKAAAQRASKQGRTPDSQIPQAKSTAMRLAMERQRATRVLPVGVAEAKGGLRIGAAPNRNGETERFFEQDWGGRVRPLCLWTSEGISGTLSFPMREMDSSEGRHAAMHSGKTRKPLVLSGRESAIRYKALVTRYEGSPGDDQIRNGNRKAGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEP4</accession>
    <name>Q2HEP4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">hydroxymethylglutaryl-CoA reductase (NADPH)</fullName>
            <ecNumber evidence="2">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_01310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="2"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220531.1">
        <property type="nucleotide sequence ID" value="XM_001220530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEP4"/>
    <dbReference type="STRING" id="306901.Q2HEP4"/>
    <dbReference type="GeneID" id="4388336"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01310"/>
    <dbReference type="eggNOG" id="KOG2480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001734_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HEP4"/>
    <dbReference type="OMA" id="FKWGFNI"/>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ93075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="305" mass="32270" checksum="4C1A2D70F8E534BA" modified="2006-03-21" version="1">MKDFTRAVKIRRTIISRTKATADLTGVLERSKLPYQGYNWAQVHGACCENVIGYMPLPVGVAGPLVIDGQSYFIPMATTEGVLVASTSRGCKAINSGGGAVTVLTADGMTRGPCVSFETLERAGAAKLWLDSEKGQSVMKKAFNSTSRFARLESMKTAIAGTNLYIRFKTTTGDAMGMNMISKGVEHALSVMVGEGFEDMNIVSVSGNYCTDKKPAAINWIDGRGKSVVAEAIIPAEIVKTVLKTDVDSMVELNINKNLIGSAMAASVGGFNAHAANIVAAVFLATGQDPAQVVESANCITIMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HF57</accession>
    <name>Q2HF57_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome alpha-type subunits domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220368.1">
        <property type="nucleotide sequence ID" value="XM_001220367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HF57"/>
    <dbReference type="FunCoup" id="Q2HF57">
        <property type="interactions" value="1122"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HF57"/>
    <dbReference type="GeneID" id="4388146"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01147"/>
    <dbReference type="eggNOG" id="KOG0184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HF57"/>
    <dbReference type="OMA" id="VEPNGAC"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="30076" checksum="DA7F4B09321913BD" modified="2006-03-21" version="1">MAANFQVEYAVKAVENGWHLDRHPVARTGVRIWLVEKLRHIQACFKPNANKRIRDWSNRHSGRPPHTQVYSGMIPDGRHFIERARDEARAWRDTFKTPIATADLAARMGGYMQAYTLYQSVRPFGITAIVGGFDSAAETPVDGEVGSGPACGAGGKVAGKTHGGPFLYMIEPSGLYWGYYGAATGKGRQAAKAELEKLDLGGPGGPALTMEEAVKEAARILYVAHDDDKEFELEMTWISGADGPTKGAHHEVPKALREEAERLAKQAQEEKMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HF64</accession>
    <name>Q2HF64_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cwf19-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_01140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220361.1">
        <property type="nucleotide sequence ID" value="XM_001220360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HF64"/>
    <dbReference type="FunCoup" id="Q2HF64">
        <property type="interactions" value="980"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HF64"/>
    <dbReference type="GeneID" id="4388061"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01140"/>
    <dbReference type="eggNOG" id="KOG2476">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019955_3_0_1"/>
    <dbReference type="InParanoid" id="Q2HF64"/>
    <dbReference type="OMA" id="IVPITHY"/>
    <dbReference type="OrthoDB" id="444325at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061632">
        <property type="term" value="F:RNA lariat debranching enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07380">
        <property type="entry name" value="MPP_CWF19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF4">
        <property type="entry name" value="CWF19-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="3">
        <location>
            <begin position="329"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="2">
        <location>
            <begin position="498"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ92905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="581" mass="63986" checksum="69644F54A10615A7" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFD6</accession>
    <name>Q2HFD6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220289.1">
        <property type="nucleotide sequence ID" value="XM_001220288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFD6"/>
    <dbReference type="GeneID" id="4386504"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01068"/>
    <dbReference type="HOGENOM" id="CLU_1272128_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HFD6"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="217" mass="24474" checksum="E1983591655FE32C" modified="2006-03-21" version="1">MCVSFLDSWLVSPPVLGYLMGPPAANERWNEGGRRNGALRTIRPEGLEAFQRSAETARVANNLAWDPTRWSGDVRERGVREEMVPRFLSTRRLFFQRQNTTDPPCRLAQPLTTEQRAAGSVDNGRLSVGPGLGIRGRQEPHLAPWTMLQYFLFAVAAEILRTAGMSRFCMRVSQPSGCMRRMGVSMSPWTAQHHRTKQHQNTPSQTKPLYGSDHDPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFN8</accession>
    <name>Q2HFN8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_00966</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220187.1">
        <property type="nucleotide sequence ID" value="XM_001220186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFN8"/>
    <dbReference type="FunCoup" id="Q2HFN8">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HFN8"/>
    <dbReference type="GeneID" id="4387282"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00966"/>
    <dbReference type="eggNOG" id="KOG3140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041954_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HFN8"/>
    <dbReference type="OMA" id="YHDEFTD"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="115"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="258"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="174"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="394"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ92731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="426" mass="45206" checksum="E4D78A3439FF501D" modified="2006-03-21" version="1">MPPPQGDDVFHDASSNRATSPPTIITTRPSTDTPTELNTNNLPPPPWTPRPKTPGVRRLSPGRPGTASTTHTTATTITTLTTTTKSFLTTTLTTLTYLYQRYTHFYASLPLHYQILVSLSGLLILTLTILLLIYSHTILVALGAAAQTWRARPLGWLPLWLATVATGFPPLIGYSTCVTLAGFVYGFPAGWPLAASATVVGSAGAFAASRGVLRGYVQRLVGADARFVALGQVLRRDGLGVLVMIRLCPLPYSLSNGFLATVGSLGVGQFVLATLAATPKLLVHVFIGWQLSQLAEPGDKMSGASRAINYISMAAFGLLGFSVGLFIYRRTMARAAELAREAQLEAGEALLDGHDEVEEGITGDDLESGRMVDPDELDAAALMDDDDISLWDASGDGYHDSWDDEPAGNGFGSNGRGKGGINGATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFX3</accession>
    <name>Q2HFX3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_00881</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220102.1">
        <property type="nucleotide sequence ID" value="XM_001220101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFX3"/>
    <dbReference type="STRING" id="306901.Q2HFX3"/>
    <dbReference type="GeneID" id="4386710"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00881"/>
    <dbReference type="eggNOG" id="KOG3334">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127829_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HFX3"/>
    <dbReference type="OMA" id="NMNPPFP"/>
    <dbReference type="OrthoDB" id="341924at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="15"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ92646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="157" mass="16493" checksum="9C53A6397C45A322" modified="2006-03-21" version="1">MSTTGGAAPQTNGVPSSAASTSQTLTNNTQTQQPPSQSQPGQTQPSATTPSQTQPPNPQQPQPPQNPPPQPQQQPTTHPNPTPSSSTAPRPRDARTIELLLTAQGVTAFEQRVPLLLLDFAYRHTSAVLSDALHLAADPYTSHAGARPSDGVRRRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG81</accession>
    <name>Q2HG81_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219994.1">
        <property type="nucleotide sequence ID" value="XM_001219993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG81"/>
    <dbReference type="GeneID" id="4386861"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00773"/>
    <dbReference type="HOGENOM" id="CLU_134521_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HG81"/>
    <dbReference type="OrthoDB" id="4156595at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="169" mass="18433" checksum="5E59A87BA9051336" modified="2006-03-21" version="1">MSAPPVPVSANQGDAPRPREPSTLYKATPGRGGLGYHSLRHSIPVARLTAETPPTTNTNRHRTRRVLRPWLHRVVYRYQPYRYANSSTRPAAEPGNSPGGARGASDGGGGGAGEYYHSKQRELMRMEAEEAFEMRSVVVVGLGLVSVVVEWMVWRVVGWMVGVVGGLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGK7</accession>
    <name>Q2HGK7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_00647</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219868.1">
        <property type="nucleotide sequence ID" value="XM_001219867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGK7"/>
    <dbReference type="FunCoup" id="Q2HGK7">
        <property type="interactions" value="189"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HGK7"/>
    <dbReference type="GeneID" id="4386721"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00647"/>
    <dbReference type="eggNOG" id="KOG2661">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029002_1_2_1"/>
    <dbReference type="InParanoid" id="Q2HGK7"/>
    <dbReference type="OMA" id="RFNCYSE"/>
    <dbReference type="OrthoDB" id="7464992at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="9">
        <location>
            <begin position="210"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="43"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ92412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="422" mass="47693" checksum="7CF1E303C2171CC5" modified="2006-03-21" version="1">MLKVLRPRPFLAQGPSAMRRLRPPPPRPIASRLQVTARCMPLNSAYSSQPPPHTVEPFPPRPSPIRPFHPPTRPTPTALPHPQQQHHQHRTYNYHPDNRHRRTPSPQPYTDPAYRDARLLAAKPLIHWRGFRALHTPTTYTILLAVAGGLLAFYFAHLETVPVSGRTRFNAYGAASVRRAGELEQRRLLWQLEQQGVRVLPEWDGRVVRVRRVMERLLPFSGMVGLEGMEGEEWEVCVVDDPRTANAFVLPGGKVFVFSGILGLARNDSGLATVLGHEIAHNLAGHHGERLSQDIKASVVLYTMMVLGGAFGLGPLIMHYFGSRFLDVAFGFPMSRLQESEADYIGLMMMAEACYDPQEAARFWERMERATGQEMPEWMSTHPAIQEWLPEAMEKRAQSDCSSTTAFADLFRHAMRTGQVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGU0</accession>
    <name>Q2HGU0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219785.1">
        <property type="nucleotide sequence ID" value="XM_001219784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGU0"/>
    <dbReference type="GeneID" id="4387127"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00564"/>
    <dbReference type="eggNOG" id="ENOG502T4A5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_391800_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGU0"/>
    <dbReference type="OMA" id="GYHIKCK"/>
    <dbReference type="OrthoDB" id="4755921at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="704" mass="76615" checksum="2B672BCE49D2BAA5" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGU5</accession>
    <name>Q2HGU5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GON domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_00559</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219780.1">
        <property type="nucleotide sequence ID" value="XM_001219779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGU5"/>
    <dbReference type="STRING" id="306901.Q2HGU5"/>
    <dbReference type="GeneID" id="4386203"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00559"/>
    <dbReference type="eggNOG" id="KOG2768">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026663_0_3_1"/>
    <dbReference type="InParanoid" id="Q2HGU5"/>
    <dbReference type="OMA" id="CMREGNK"/>
    <dbReference type="OrthoDB" id="10255414at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012314">
        <property type="entry name" value="Pept_M12B_GON-ADAMTSs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51046">
        <property type="entry name" value="GON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GON" evidence="6">
        <location>
            <begin position="227"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ92324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="336" mass="36725" checksum="EEBCE4BFDD476025" modified="2006-03-21" version="1">MTTEEPTIQRRASRKSVAFTEEKLVVDADGSVTMIATPNDDTKDTAMSHTPRTPPLSAALGAFTDASSAPADDAAPAADLNADGLDLSLMKKKKKKVKKDDDEGADSGAVAGDEEAIDLSMKKKKKKKAPKEEDEFAKKLEALNLEGGEGAEAAADEGVQEGDMDKGTGIWGHNESRTINYNPLLSRFFALLAQKNPDHASTGTRSYKIPPPQCLREGNKKTIFANLPEICKRMKRADEHVTAYLFAELGTSGSVDGSRRLVIKGRFQQKQIENVLRTYIIEYVTCKTCRSPNTELSKGENRLYFITCNSCGSRRSVQAIKTGFSAQVGKRRKMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH67</accession>
    <name>Q2HH67_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_00437</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219658.1">
        <property type="nucleotide sequence ID" value="XM_001219657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH67"/>
    <dbReference type="FunCoup" id="Q2HH67">
        <property type="interactions" value="849"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HH67"/>
    <dbReference type="GeneID" id="4388269"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00437"/>
    <dbReference type="eggNOG" id="KOG1184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_0_2_1"/>
    <dbReference type="InParanoid" id="Q2HH67"/>
    <dbReference type="OMA" id="IHGPEQR"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="15">
        <location>
            <begin position="16"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="13">
        <location>
            <begin position="210"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="14">
        <location>
            <begin position="408"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAQ92202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="574" mass="63504" checksum="72EAB838443D3DF1" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH95</accession>
    <name>Q2HH95_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219630.1">
        <property type="nucleotide sequence ID" value="XM_001219629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH95"/>
    <dbReference type="STRING" id="306901.Q2HH95"/>
    <dbReference type="GeneID" id="4387274"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00409"/>
    <dbReference type="eggNOG" id="KOG2865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_4_1"/>
    <dbReference type="InParanoid" id="Q2HH95"/>
    <dbReference type="OMA" id="PEDQFTN"/>
    <dbReference type="OrthoDB" id="275457at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05271">
        <property type="entry name" value="NDUFA9_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000358">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 39 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="54"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="377" mass="42920" checksum="53424E74C39D9068" modified="2006-03-21" version="1">MASLPTVVRATAPKIARSALQRRAIHSDVHITRTGKPILRTTGGRSSLGGHTATVFGATGQLGRYIVNRLARQGCTVIVPYREEMAKRHLKVTGDLGRVVFIEYDLHNTQSIEESVRHSDVVYNLVGRNYPTKNFSLGDVHIEGTERIAEAVAKYNVDRFIHVSSYNANPQSASEFYATKGYGEKVARDIFPETTIVRPAPMFGFEDKLLLKLASVANLFTANNMQETYWPVHVIDVGEALEKMMFDDNTASQTFELYGPRQYSTAEIAELVDREIYKKRRHINLPKALLKPAAGLLNRFIWWDIMSADEIEREFHDQVIDETAKTFKDLGMEPSDISKWTYHYLKGFRSSAFYDLPPATEREKREEKKYIHVLDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHR7</accession>
    <name>Q2HHR7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219458.1">
        <property type="nucleotide sequence ID" value="XM_001219457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHR7"/>
    <dbReference type="GeneID" id="4386593"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00237"/>
    <dbReference type="HOGENOM" id="CLU_1602492_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHR7"/>
    <dbReference type="OrthoDB" id="10349832at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209265" evidence="1">
        <location>
            <begin position="21"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="171" mass="18819" checksum="32B44EC4689DC1C5" modified="2006-03-21" version="1">MQLSSLFLSATALLAQAASADYLLYSSRRALFNPPAQIQTRPPAGYLPGCVGFTRTRSQNAEIALDAEGDIGSKFFLLQTTPTTWALHSKEHSYYPITEPGDLLVITGPFTVDESGRFVYNGTEVEDAGWVACKQKRNEGFSTIYLTASSVQDESCREVEVYAYDTNQRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI43</accession>
    <name>Q2HI43_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219332.1">
        <property type="nucleotide sequence ID" value="XM_001219331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HI43"/>
    <dbReference type="STRING" id="306901.Q2HI43"/>
    <dbReference type="GeneID" id="4388055"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00111"/>
    <dbReference type="eggNOG" id="ENOG502SJ6A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_934414_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HI43"/>
    <dbReference type="OMA" id="HHTHLGD"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF7">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="310" mass="35452" checksum="94F76320FA85ABA7" modified="2006-03-21" version="1">MSDLVPPSDSPVSASSVQQGTETTTPPTSLEEAPKPSLQQPLGYATVGRRAHKKSRTGCSTCKSRKIKTYTTLTADPSVWEFWRDDVVQLGLTCDYIMRAVLAVSALHLAYHQPDRRDFYVEAGILLHQKASRSAMRVMAAEDRIDKDRAASLFLFSMLTMFFAPLRTRVQDTVTEAFLLKTYTHSLDELDRALVVRHDPAAPREVLDAMVWLWVMSDEFVPLLRVPTQEAVAIFAHFCVLLKYYESHWWLQGWGEHIMMRAREILDEEHRGWIEWPLREMGWMEGVEGLLLGRKGERERGKGREEDKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI74</accession>
    <name>Q2HI74_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CHGG_00080</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219301.1">
        <property type="nucleotide sequence ID" value="XM_001219300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HI74"/>
    <dbReference type="GeneID" id="4387620"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00080"/>
    <dbReference type="eggNOG" id="ENOG502RY3D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031730_1_3_1"/>
    <dbReference type="InParanoid" id="Q2HI74"/>
    <dbReference type="OMA" id="YEGFSRW"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF34">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209342" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="17">
        <location>
            <begin position="21"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="18">
        <location>
            <begin position="19"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="245"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAQ91845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="299" mass="32112" checksum="5E0526C4C760FB05" modified="2006-03-21" version="1">MARQLSLVATLLATRVAAHGYINTFTLDGEDYEGFSRWNPSPDPNAIGWSFTTEDEGPELDFSSPDFICRRGAEASSNYGTIAAGGTASFFWTSDDKVINPNGWAESHRGPVLTYIAPCNGDCASVDKTSLRWTKIAESGLASGPANTQGIWATDVLRQNGGINTATIPKSIAPGKYVLRNELIALHRAHINEPEFYMQCGNIEVTGSGTDDLSGSGVPAGELYSKSDSQLFGFSVYDSRDNEWPIPGPALYEGSSAQQSGDSEDSEDSEESEESEQAEPSPSPAPRPGKPGSARCRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HIE5</accession>
    <name>Q2HIE5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219230.1">
        <property type="nucleotide sequence ID" value="XM_001219229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HIE5"/>
    <dbReference type="GeneID" id="4387174"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00009"/>
    <dbReference type="eggNOG" id="ENOG502S098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_489151_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HIE5"/>
    <dbReference type="OrthoDB" id="5093543at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="557" mass="61789" checksum="009778B3A65A4485" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GLZ2</accession>
    <name>Q2GLZ2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_11064</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408038">
        <property type="protein sequence ID" value="EAQ82888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230240.1">
        <property type="nucleotide sequence ID" value="XM_001230239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GLZ2"/>
    <dbReference type="GeneID" id="4397371"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_11064"/>
    <dbReference type="eggNOG" id="ENOG502QTQ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044876_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GLZ2"/>
    <dbReference type="OMA" id="YEWSLAC"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF7">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="9"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ82888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="325" mass="34794" checksum="0A5A7B2DB54B3A01" modified="2006-03-21" version="1">MSTATKSLERVAIIGASGRIGGAFAKSLLATGQHTVTALTRAGSNSTLPEGVTKIAVNYDDEASLLAALQGQQFLAITLGVDAPPDLHGRIAAAAGKAGVPYVMPNAYGFPPASNPTPDDIYAKFALQRVADVTGNGVSAALTMSCGFWYEWSLALGNEWFGFEIRERKVTFFDDGLRTITVSTWDQCGRALAALLSLPETGASPSLADFKNGQVLVHSFRVSQRDMLDSLHRVLGTTDADWEISYEPVAKRVKEGAAELKQGNRRGFAKTLYGGIFDAANDSSDFAGTSKTATETLGLPKEDLDEATKRAVDMVMNEWKPFEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMC6</accession>
    <name>Q2GMC6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_10878</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226145.1">
        <property type="nucleotide sequence ID" value="XM_001226144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMC6"/>
    <dbReference type="GeneID" id="4397184"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10878"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_2_1"/>
    <dbReference type="InParanoid" id="Q2GMC6"/>
    <dbReference type="OMA" id="YQSVDPE"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF210">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ83060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="577" mass="61626" checksum="65966F476174461F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMG3</accession>
    <name>Q2GMG3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AmmeMemoRadiSam system protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226108.1">
        <property type="nucleotide sequence ID" value="XM_001226107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMG3"/>
    <dbReference type="FunCoup" id="Q2GMG3">
        <property type="interactions" value="450"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GMG3"/>
    <dbReference type="GeneID" id="4397317"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10841"/>
    <dbReference type="eggNOG" id="KOG3086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038085_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GMG3"/>
    <dbReference type="OMA" id="MHLPYIH"/>
    <dbReference type="OrthoDB" id="417112at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="33567" checksum="CDCA87BA70937415" modified="2006-03-21" version="1">MTTREASHAGSWMRNSHAGYSYSGPCAAWAYKALDLRSAKRVFILGPSHTYYLRGCALTSFDKYETPFGDLVVDNATTSELRQTNRFSEMPKRSDVSEHSLEMHLPYLRKRLEQTFGDGDYPPIIPILVGDASGDEEKSWGQLLSKYLKDPESAWIVSSDFCHWGSRFTYRPKFRDGVIRDLDNDRGALQVTPDWSQVAEDPESPEIHEVIEVLDQMAIDAVESGSHSEFSKVIRQTQNTVCGRHPIGVMMAALEAVAEERGLEGKNGKFSFVQYQRSNLVKRDKDFSVSYASAYAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMR6</accession>
    <name>Q2GMR6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ82920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226005.1">
        <property type="nucleotide sequence ID" value="XM_001226004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMR6"/>
    <dbReference type="GeneID" id="4397229"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10738"/>
    <dbReference type="eggNOG" id="ENOG502RVSP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003335_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GMR6"/>
    <dbReference type="OrthoDB" id="5372708at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ82920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1162" mass="129668" checksum="4658DA417071EE95" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMS1</accession>
    <name>Q2GMS1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ecp2 effector protein-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ82915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226000.1">
        <property type="nucleotide sequence ID" value="XM_001225999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMS1"/>
    <dbReference type="GeneID" id="4397126"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10733"/>
    <dbReference type="eggNOG" id="ENOG502T123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1415762_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GMS1"/>
    <dbReference type="OMA" id="VITNDCC"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029226">
        <property type="entry name" value="Ecp2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14856">
        <property type="entry name" value="Hce2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004207951" description="Ecp2 effector protein-like domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Ecp2 effector protein-like" evidence="2">
        <location>
            <begin position="96"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ82915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="215" mass="22488" checksum="039BB333BB780252" modified="2006-03-21" version="1">MLVVNLAGLALLAIFGQTTLAAPAVNVAAARDPSQDFMAGVDTSTWVSVQFHGKTITYNPDALVVNATVASTSETSAKRSVLHKRGPCIGGSNEDCCGGSSFSGTPAPWAWTSDCAAIRDWAYNQHTTFNVHGITGDYYGIVFAGSCAFGAGTWNWYTTYMGSTDIGDLTRDGINMFAGSNGQVGAQGSMKCSNSAFSDPSSGSDVFWKLQCNGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN60</accession>
    <name>Q2GN60_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228521.1">
        <property type="nucleotide sequence ID" value="XM_001228520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN60"/>
    <dbReference type="STRING" id="306901.Q2GN60"/>
    <dbReference type="GeneID" id="4397082"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10594"/>
    <dbReference type="eggNOG" id="ENOG502S6Y9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_672686_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GN60"/>
    <dbReference type="OrthoDB" id="5134445at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="45830" checksum="4DB7DB0432695524" modified="2006-03-21" version="1">MTKSSCKAEKCRDAAYSFIDQIFILFLDLRVPWDNSRTCNRWPAEVPSLPELVYQMGSAFSTFYEVKGLGGMMAAGITVQGHGEGVATPSFDEIGAFENQVITNGDSATAHYQTHNRRDHNRPDATSISSGGSAAKTGFLKLYDRRFARSLRAQEGAGKWTHDIEDTYVESIRTGSIQQFAHDLRHVEGFRDAQSELDAPDIAQDEAYINGTMVRDHTPELAVHNALHDQQGKVVPRLLAAVDLDLTRPGAENDELFHIKGILLEYIEGFRMSKFPDETPPSAWQNIVDQAIAAVNVLGDYHILDTDRRPDNFIVTPDKKGGFHVFMVDFGCARFKREDESEAEWASNKVTENEETGVGTVCQKCLARDYGFCLEYKPSDRWLEAGLEYGRALARVDIERYEKEKAEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN89</accession>
    <name>Q2GN89_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228492.1">
        <property type="nucleotide sequence ID" value="XM_001228491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN89"/>
    <dbReference type="GeneID" id="4396444"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10565"/>
    <dbReference type="eggNOG" id="ENOG502SCK8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044881_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GN89"/>
    <dbReference type="OMA" id="IDEVACE"/>
    <dbReference type="OrthoDB" id="4576088at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="239"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="381" mass="43924" checksum="68170C24F27C8E8D" modified="2006-03-21" version="1">MPSSDLSDGELRRRATSTIYRENKTLRIREHLPPEPFTGDYGPSPRPEVDWSPWQDVPYWQIDRVEFALANPPIETEPPTGPERTLTIGRTLTRPSRGGISVVTCFLDGDRSVEYVAKIYDGVDYLLSAWDDGTEYEGKGGHLDCMKWADRDYSIEAWAYRTMLPVIGNTGIVPAYHGSWTFALQTDQPGRQRWVRMILIELVQGECMLDLMNRGEKEPGSGKMDYALLPPEEFRLRVLQNILEAEVTIWRETAVLHNDIEPRNIMVKPDGNIVIIDFNQATIYDFILYDLKHPKDTDPDSLPLTPIEWHWPLPKSFDKWARWVPEKWLEDKELSAEWLILTYRGSPRFEPASAGFLDHPVHLRRSKRVQKLLEGLGRKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNA5</accession>
    <name>Q2GNA5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_10549</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="1"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228476.1">
        <property type="nucleotide sequence ID" value="XM_001228475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNA5"/>
    <dbReference type="GeneID" id="4395962"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10549"/>
    <dbReference type="eggNOG" id="ENOG502S8FT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056607_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNA5"/>
    <dbReference type="OMA" id="RSCHWVV"/>
    <dbReference type="OrthoDB" id="329272at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="170"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ84145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="287" mass="31921" checksum="37706096C5C30A3A" modified="2006-03-21" version="1">MGTPFISLLEPTALDWERGLPPDEQPNAASIPRTFLDAMTVRTQVFVQEQQIPQANEFDADDQRCAHWVIYASVNKTVAPAVTDPDTGEVLCPRQSETQSVPIGTVRLVPFPHPPHPLNGGVYVDNELIRSESESAQDNDKPTEPTTTTTAPTQQPTFTPDRPTTFHDGIEPYVKLGRLAVIKEFRGRGIAGQLVRTAVEWMRTHGTYFDPSPAARGFEHLGMERQAGALPPRWNGLLCCHAQEDAVKVWEKCGFRVDEGMGRWFEEGIPHVGMFLRVDAEPEVKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNE4</accession>
    <name>Q2GNE4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ca2+-modulated nonselective cation channel polycystin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228437.1">
        <property type="nucleotide sequence ID" value="XM_001228436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNE4"/>
    <dbReference type="GeneID" id="4396215"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10510"/>
    <dbReference type="eggNOG" id="ENOG502SFF8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035522_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNE4"/>
    <dbReference type="OMA" id="AKNNPYP"/>
    <dbReference type="OrthoDB" id="5377012at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="42610" checksum="4BEB35046665B48F" modified="2006-03-21" version="1">MAMAETAAQPHDQPGRLGRRRPFSALMKKLANLKATSSSDGGRHSNSKRHGTKKPLNNPYPQSGRIAIASSPHHSHYSVSSGPSRRLTSVTSLDRADSVQLSHDGQPPPTTGGRSMAPTYIEPNKGHAAPIIAPAHGDTSVAGTSRTANGRRGGDSTFSSPAPSVRSLTTTLTTIQTVAPATGNNNQTTTNQHSHNSNSQVIHFNQPFPTGSPASAIPAHLASGTTGASSPATYHTATANNLLTDNASILTLASSSKRRRRRSFDTDASVRALAPSSLWGGSRESLPLSVLSATMDGTVGGPTTPGLHRGASSGMGGIGANERTSIYSATGILGTTAASERNSFYAKQGYGSGDGASVRSGLFGHGRADSVAGSIGGGLAVPPSGTSPLASPREGVEEEKELEQEKVEAEKEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNQ9</accession>
    <name>Q2GNQ9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_10395</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ELP1/IKA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228322.1">
        <property type="nucleotide sequence ID" value="XM_001228321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNQ9"/>
    <dbReference type="FunCoup" id="Q2GNQ9">
        <property type="interactions" value="934"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GNQ9"/>
    <dbReference type="GeneID" id="4396255"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10395"/>
    <dbReference type="eggNOG" id="KOG1920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001477_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNQ9"/>
    <dbReference type="OMA" id="WRESLYC"/>
    <dbReference type="OrthoDB" id="40048at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056167">
        <property type="entry name" value="A-sol_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056164">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056165">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006849">
        <property type="entry name" value="Elp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056169">
        <property type="entry name" value="HB_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056166">
        <property type="entry name" value="TPR_ELP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23925">
        <property type="entry name" value="A-sol_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04762">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23797">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23936">
        <property type="entry name" value="HB_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23878">
        <property type="entry name" value="TPR_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017233">
        <property type="entry name" value="IKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ELP1 first N-terminal beta-propeller" evidence="7">
        <location>
            <begin position="1"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 N-terminal second beta-propeller" evidence="8">
        <location>
            <begin position="417"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 alpha-solenoid" evidence="10">
        <location>
            <begin position="607"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 TPR" evidence="9">
        <location>
            <begin position="815"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 three-helical bundle" evidence="11">
        <location>
            <begin position="987"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1086"/>
            <end position="1109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ83991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1215" mass="132644" checksum="4DD14872EEFB1028" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNT3</accession>
    <name>Q2GNT3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228298.1">
        <property type="nucleotide sequence ID" value="XM_001228297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNT3"/>
    <dbReference type="GeneID" id="4396352"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10371"/>
    <dbReference type="eggNOG" id="ENOG502RR0P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_366375_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNT3"/>
    <dbReference type="OMA" id="DSATMMA"/>
    <dbReference type="OrthoDB" id="5226996at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="594"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="661"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="761" mass="79152" checksum="76EF2F40F9F2A857" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNV8</accession>
    <name>Q2GNV8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carbohydrate kinase FGGY C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_10346</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228273.1">
        <property type="nucleotide sequence ID" value="XM_001228272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNV8"/>
    <dbReference type="FunCoup" id="Q2GNV8">
        <property type="interactions" value="264"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GNV8"/>
    <dbReference type="GeneID" id="4396043"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10346"/>
    <dbReference type="eggNOG" id="KOG2517">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_10_1_1"/>
    <dbReference type="InParanoid" id="Q2GNV8"/>
    <dbReference type="OMA" id="HKAMWHE"/>
    <dbReference type="OrthoDB" id="203824at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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            <end position="525"/>
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</entry>
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                <person name="Untereiner W.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
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</entry>
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        </source>
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    </dbReference>
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            <end position="151"/>
        </location>
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        </location>
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    </feature>
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        <location>
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            <end position="760"/>
        </location>
    </feature>
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        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
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            <end position="125"/>
        </location>
    </feature>
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        <location>
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            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="694"/>
        </location>
    </feature>
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            <end position="716"/>
        </location>
    </feature>
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        <location>
            <begin position="739"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPM8</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="220" mass="23302" checksum="47F3C233C9BB83F9" modified="2006-03-21" version="1">MAFVDIWVAVLTLIGSITSSLIALPVLGDVLRWFGLRPLPPHDRVPELLVEVRDDQSGLVVGPTTIIGGQQGLVGGQDTIGGDLRALIDAAQSLDKNLMVAVENQKAILEVIMAITDEIEKFGDDLNSRFDNVRDVLDAIVRVTESSTEALGQMSALVAAVSGRRMAQSEPASTATQTQGTEVLKGRKGSYGATVLAACVNTAETQQLHPSILRGGGWCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPU9</accession>
    <name>Q2GPU9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CHGG_10005</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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        </lineage>
    </organism>
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            <authorList>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPU9"/>
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    <dbReference type="eggNOG" id="ENOG502T4N8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1272759_0_0_1"/>
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    <dbReference type="OrthoDB" id="4588557at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="247" mass="26723" checksum="5B56B407FADBB4E7" modified="2006-03-21" version="1">MPSFTSRHYTPDRFRSLSKPEDDLMEDVHQTAPGTKYSSSGSLTLGPSDGSLLDYFDLPSPPSTPHRPTHHNNNNLSYTSLNSFPSPATSPGLAARSPATLSRSSSTSSSRNTTPTSSPPTSTLPRWPSAAQRIHRLPTRPRSRSTSSASSAGSTSTSSSLSLSATPPALGDIDMGGMGGGVMQPPPMIRSARRTPYYPPNASRNADRARVYMNRGPHYVPNWTPLSSLPRHVQLQIEERMTRFTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQ13</accession>
    <name>Q2GQ13_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227868.1">
        <property type="nucleotide sequence ID" value="XM_001227867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQ13"/>
    <dbReference type="STRING" id="306901.Q2GQ13"/>
    <dbReference type="GeneID" id="4396674"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09941"/>
    <dbReference type="eggNOG" id="ENOG502QVK4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_618211_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQ13"/>
    <dbReference type="OrthoDB" id="5406275at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33488:SF2">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33488">
        <property type="entry name" value="ZGC:162509"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="443" mass="47875" checksum="4C19C42F114BCF44" modified="2006-03-21" version="1">MGAAINARNLAAMAAGFAAGQGGAAASNTPVASGKPQTQAAALADPAMTPQRIPRKSPKAWPTLRGQKAAIDVTNTAPNRKLLGAYTSLIKLSEELQTHLRRQNELSASKDPTEEVAKKWRATCRKARDDILELAASAKTGGSTNVPMAFGTVQIPPSDQSAQTAQLNTAMQGVQIAQSALDNAENAYNAAVEKQERMAKAMATIQARLKKLQTTGKTLEEIKTVLQDCIQVLADLMVQITRLERFFIALTTLIDVLVMPRAKLFERDVGKIGRRGMLAGVLRVEDVDKQAIYASTLQLKAYFSLLEDIATMYTIVHREHIVGGVELCYELSKGVTRNDGMPEQQEKLTKYTENASALVAALVADKQREILRTLRARDETAQIEAEMARFKIAPVDDAAKLAIENGAREQQAVAQELLASEPSVTVAAVRVAEESEGVDANEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQ92</accession>
    <name>Q2GQ92_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227789.1">
        <property type="nucleotide sequence ID" value="XM_001227788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQ92"/>
    <dbReference type="STRING" id="306901.Q2GQ92"/>
    <dbReference type="GeneID" id="4396347"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09862"/>
    <dbReference type="eggNOG" id="ENOG502RN85">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_906142_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQ92"/>
    <dbReference type="OrthoDB" id="5242786at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="307" mass="34635" checksum="206F3DE4FF4DC93F" modified="2006-03-21" version="1">MTPFVVPAPTQRSPHQPGIEVIPKRHLTDKDKSSEILHIDTSPTASYVATKHSNKLVKIWSIPKNALHGTIKITSYVQPRVRSREYFIRSHAILSENATLIGITTHFGLTLEIWNFAKGGSGAKKVQVIEEAHRWAASQRDAFHNDYAGLAVYRPKNDRIDRFFLSRHPNSKTPFREDPNHSIELRKSNLPFLPKFPELAYSSDSPILIAAASPRPGDPSPPQLNHPHRLAHEARLGQQAARADPRPVAQLSPRRRAAQALPGLRARLPSPAVRPARQPRLTRRHCRLHLDPSRHHHRHHGHHLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQH3</accession>
    <name>Q2GQH3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase</fullName>
            <shortName evidence="11">HMP-P synthase</shortName>
            <shortName evidence="11">Hydroxymethylpyrimidine phosphate synthase</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_09781</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 2 Fe(3+) + 4 H2O = L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 3-oxopropanoate + 2 Fe(2+) + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65756"/>
            <dbReference type="Rhea" id="RHEA-COMP:16892"/>
            <dbReference type="Rhea" id="RHEA-COMP:16893"/>
            <dbReference type="Rhea" id="RHEA-COMP:16894"/>
            <dbReference type="Rhea" id="RHEA-COMP:16895"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:33190"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:143915"/>
            <dbReference type="ChEBI" id="CHEBI:157692"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:65757"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the NMT1/THI5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227708.1">
        <property type="nucleotide sequence ID" value="XM_001227707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQH3"/>
    <dbReference type="FunCoup" id="Q2GQH3">
        <property type="interactions" value="104"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GQH3"/>
    <dbReference type="GeneID" id="4396716"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09781"/>
    <dbReference type="eggNOG" id="ENOG502QQ87">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028871_6_3_1"/>
    <dbReference type="InParanoid" id="Q2GQH3"/>
    <dbReference type="OMA" id="TKHYGMT"/>
    <dbReference type="OrthoDB" id="434407at2759"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13650">
        <property type="entry name" value="PBP2_THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000187">
        <property type="entry name" value="4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027939">
        <property type="entry name" value="NMT1/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528">
        <property type="entry name" value="4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE PHOSPHATE SYNTHASE THI11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528:SF1">
        <property type="entry name" value="4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE PHOSPHATE SYNTHASE THI11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SsuA/THI5-like" evidence="12">
        <location>
            <begin position="16"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ83377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="342" mass="38245" checksum="DD1CD4DBC43F36A5" modified="2006-03-21" version="1">MSTDKITFLTNWHATPYHAPLYLAQAKGYFKDEGIKVALLEPNDPSDVTEIIGTGKVDLGFKAMIHTLAAKARDFPVLSIGSLLDEPFTGVVYLKSSGITTDFRTLKGKRIGYVGEFGKIQIDELTSHYGMSPSDYTAIRCGMNVSKAIIEGSIDAGIGLENVQMVELEEWLAAQGRPKTDVQMLRIDELAELGCCCFCSILYIGNERFIAENPDKVRAFLRAVKRATDFVLAQPEQAWAEYVDFKPVMGSALNRKIFERSFAYFSRDLKNVKRDWEKVTKYGKRLGVLDASFEPNYTNEFLEWTLEADSKDPTGDQKRMAALQKDIAQVGGFQRLESKVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQJ1</accession>
    <name>Q2GQJ1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227690.1">
        <property type="nucleotide sequence ID" value="XM_001227689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQJ1"/>
    <dbReference type="GeneID" id="4396334"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09763"/>
    <dbReference type="HOGENOM" id="CLU_1219574_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQJ1"/>
    <dbReference type="OrthoDB" id="3508621at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="227" mass="23356" checksum="2A9139F35CBEE4B6" modified="2006-03-21" version="1">MHPSTIQNKSTTAGMTTAQAKKAVAAISTTPVYDLGETLGSPAFLDQAYALNLGDRVDGWDKPEIQAVIAARRPPPPDGGGPSGGGGPGASSKPPPSNGGSRSSSTAPKSGGNKPPAGPSSISGSLPLRPASPPKPKEGAPDRDNRSRPTTRLSAAKVKADANTKANVGPGHRPGSGTPPTPPDLGLPRIGEFLVMHRFGPWKTNDMSNMKVFIRRLLGLMPELKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GR69</accession>
    <name>Q2GR69_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227462.1">
        <property type="nucleotide sequence ID" value="XM_001227461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GR69"/>
    <dbReference type="GeneID" id="4395189"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09535"/>
    <dbReference type="HOGENOM" id="CLU_1916836_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GR69"/>
    <dbReference type="OrthoDB" id="10481559at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="132" mass="13919" checksum="C3346292BC96017A" modified="2006-03-21" version="1">MPYIIYTHTKRAGHHSPAAPAAPAVPAPAVQPAVPRPPQPPPVTQPRRRNIRAKIDQAFEVPAPAPAAAVTHALPVEVHPAVEAGGGLAAQVLEGDAVWILRLDMDMGGLFVGSSSNTTATLWVLWSLYFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRQ9</accession>
    <name>Q2GRQ9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_09345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227272.1">
        <property type="nucleotide sequence ID" value="XM_001227271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRQ9"/>
    <dbReference type="GeneID" id="4395109"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09345"/>
    <dbReference type="eggNOG" id="ENOG502SJAG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_462309_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRQ9"/>
    <dbReference type="OMA" id="WWFFVLC"/>
    <dbReference type="OrthoDB" id="3231000at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="564"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ85331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="590" mass="65607" checksum="657358A53FA45D4A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRS6</accession>
    <name>Q2GRS6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_09328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227255.1">
        <property type="nucleotide sequence ID" value="XM_001227254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRS6"/>
    <dbReference type="STRING" id="306901.Q2GRS6"/>
    <dbReference type="GeneID" id="4395523"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09328"/>
    <dbReference type="eggNOG" id="ENOG502SUU2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072870_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRS6"/>
    <dbReference type="OMA" id="CDEVSCP"/>
    <dbReference type="OrthoDB" id="4154404at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208127" evidence="2">
        <location>
            <begin position="20"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ85314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="307" mass="31610" checksum="FC933AF48E82C1D8" modified="2006-03-21" version="1">MPPRTLLTLLAAASVHVHGASILSCADVDCPITEGTTSATCTVADRTFNAVGLTSLDAGGNDRLRGLSWVKAVGAQDHPENRTRVFDPELLSRHAGMSLTLRIPEACAVFFTQVSDGVRFGEGDQGIAQGTCGDALGDAFAVGAQWTGIEARPINGDGAPEEIEDRQNRTTNCWPVLPKTDDLTLVQSVMTLGDFDASVLVDNFFGITPILTVFFPENDNDDGDDTDSDNLVTQTVAQLTCIKAIDMTTASNETQSPGGNENGNGGNGGNGGNGGNGDDGNAAGRMVASGSLAALGGLLSAALVLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSZ1</accession>
    <name>Q2GSZ1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CNNM transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_08913</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226840.1">
        <property type="nucleotide sequence ID" value="XM_001226839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSZ1"/>
    <dbReference type="FunCoup" id="Q2GSZ1">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GSZ1"/>
    <dbReference type="GeneID" id="4395477"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08913"/>
    <dbReference type="eggNOG" id="KOG2118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011310_3_0_1"/>
    <dbReference type="InParanoid" id="Q2GSZ1"/>
    <dbReference type="OMA" id="PLPRFQL"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="5">
        <location>
            <begin position="60"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="357"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="444"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="566"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="644"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="450"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="573"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="703"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="746"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ84899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="760" mass="81176" checksum="2DA989B76776F301" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GT14</accession>
    <name>Q2GT14_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_08890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226817.1">
        <property type="nucleotide sequence ID" value="XM_001226816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GT14"/>
    <dbReference type="STRING" id="306901.Q2GT14"/>
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    <dbReference type="eggNOG" id="KOG0157">
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    </dbReference>
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    <dbReference type="OMA" id="EMHANDE"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24296">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ84876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="47107" checksum="5C50C76F7F8D30C8" modified="2006-03-21" version="1">MGLVVEYGNYLVVAAALAILIRAVSRPGKAITRNGEPLRNPPNTLPLVGNGIKFLQSRWDLLSWFEQCQREFGYETAALSVPTLPPGVLIHDPKNLEFVFKNEGLFTKGDFVKRRSWDLFGNGIINADGDFWKLQRKAGVAFLNTANLRVLTDVALPQYLAESAEYLNSKADKDTVDLQHMEMHANDEFSLSFDYASGITAERFQNPLWRVTELFTGSRFRRSVAVIKSFGRRIVTSAVKDRNDQKSNSEAASDPNDDSKLDEISGSLIQSLLEALGDETTVADAALTYLSAGRDTTGQALTWTFYLLLQHPTAITKIRAEVIPRRVLGFALEKGVGRADGGEAEPDELDSAYGGGVACEGEGEEEGGTGRIGMGVVGCGWPQLSESVEFVSCMYQALNLTRIGRLGRKPGSHVPFESRGFVIFLSQLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTC3</accession>
    <name>Q2GTC3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">L-ascorbate oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_08781</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001226707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTC3"/>
    <dbReference type="GeneID" id="4395732"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08781"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_8_3_1"/>
    <dbReference type="InParanoid" id="Q2GTC3"/>
    <dbReference type="OMA" id="QWPIAPH"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017762">
        <property type="entry name" value="Multicopper_oxidase_fun"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03390">
        <property type="entry name" value="ascorbOXfungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208581" description="L-ascorbate oxidase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="40"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="162"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="454"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ84767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="645" mass="71152" checksum="3F24553B3C761624" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTE8</accession>
    <name>Q2GTE8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_08756</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226683.1">
        <property type="nucleotide sequence ID" value="XM_001226682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTE8"/>
    <dbReference type="FunCoup" id="Q2GTE8">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="GeneID" id="4395335"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08756"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GTE8"/>
    <dbReference type="OMA" id="GKAMSAW"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="89"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ84742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="490" mass="53168" checksum="66B127B42798392C" modified="2006-03-21" version="1">MADPSSRRTALTDEAKPSDVDVEKGIQELNSDLEATTITLDTDSEPTSRDGTAGEKGNAESKDPNIVSWDGPDDPTNPMNWTMRKKWSNVAVLSILTIITPLGSSMFAPGIPRILEEFHETSSVTATFLLSIYILGFAFGPLLVAPMSEIHGRSLLYNLGNLLFTIFTICTALSNSIGMLMAFRFLMGVAGSVPITIGSGSIADMMPVEMRGRAMAAWALGPLLGPCIGPVAGGYLIRAAGWRWVYWLIAIIAGIITVFTYFMLKESYAPVILEKKARRLRKETGNQELRSALAGNATTPTEKLKAAIVRPLKLLFRAPIVTAMALYIAVTYGILYLLFSTFSIVFPVHYGFGEGESGLVFIPSGIGMMLGIGIFGTLSDRLVKSKLDKGERHRPETRLTPFFTLPAGLAIPSGLFIYGWTIQYHVHWIVPMIGVVLFAFGLMGVMMCIQNYLLDVYPRAAASVTAALAVLRSLAGALLPLCAIDMYAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTG6</accession>
    <name>Q2GTG6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_08738</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226665.1">
        <property type="nucleotide sequence ID" value="XM_001226664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTG6"/>
    <dbReference type="STRING" id="306901.Q2GTG6"/>
    <dbReference type="GeneID" id="4395071"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08738"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_35_2_1"/>
    <dbReference type="InParanoid" id="Q2GTG6"/>
    <dbReference type="OMA" id="PAYRICI"/>
    <dbReference type="OrthoDB" id="5099253at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="9"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ84724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="396" mass="44142" checksum="E1ABA83FAAFCAECA" modified="2006-03-21" version="1">MLQRQTSVFHWNNVCYEVKVKGETRQILNNVDGWVKPGTLTALMGVSGAGKTTLLDCLADRTSMGVITGEMLVDGNPRDTSFQRKTGYVQQQDLHLQTTTVREALNFSALLRQPAHVPRAEKLAYVDEVIKLLEMEDYADAVIGVPGEGLNVEQRKRLTIGVELAAKPPLLLFVDEPTSGLDSQTSWAILDLLEKLTKSGQAILCTIHQPSAMLFQRFDRLLFLAKGGKTVYFGDIGENSKTMTSYFERNSGVSCPQEANPAEWMLEVIGAAPGSTSNVDWHQTWRDSPEYAGVQTELQRLKADVKESTPVSNDPGSYREFAASFTQQLVQVTHRVFQQYWRTPSYIYSKAALCVLVALFIGFVFFKAPNTQQGMQNRKSYFSFPLLPPTASLRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTV8</accession>
    <name>Q2GTV8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226523.1">
        <property type="nucleotide sequence ID" value="XM_001226522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTV8"/>
    <dbReference type="STRING" id="306901.Q2GTV8"/>
    <dbReference type="GeneID" id="4395103"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08596"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025001_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GTV8"/>
    <dbReference type="OMA" id="AGPRMCY"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="454"/>
        </location>
    </feature>
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        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ84582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="454" mass="49955" checksum="7D59ED21C5086D17" modified="2006-03-21" version="1">MLDSLSVRLGLLLGGALVSFILVLRKLYPKPYPGIPYNEASARRITGDMMDFAPIIQKTNEISDALFTVTTQKLGTPIAQVLFPGFRKPIILLEDPREIEDIIFTTPALKAQKRLWADTMSMDFLRRVAAPNIHKSTCELIELWRLKSSTKFKNQAFNVHSDFKDAALDAIWAVIVGEEPGTIQHDIKTLEDQMAGKASSGEAPSIGSFLKEQVSYIMTSIARNGNTPSPKWAQKLETYTPRYRKFRRVVKAEMHRAMETAVERYKSLEVARLEDDAADTCAMDLVLRRQILQARKAGVAPSDPTKDENMLDEMFSKPLSAPPCAPPSPPPPPPATTILNADIPYLDATCEETLRLSGTAKGSLRQALVDTHILGCPVPRGAEILMNYHVNRAPPGEAVDEGRRSATSRAAGEKRGDGLRGVAGRDLGVFEPRRWTEAGDDGTEDYGGDAGVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU88</accession>
    <name>Q2GU88_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226393.1">
        <property type="nucleotide sequence ID" value="XM_001226392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GU88"/>
    <dbReference type="GeneID" id="4395494"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08466"/>
    <dbReference type="HOGENOM" id="CLU_3384698_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GU88"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="33" mass="3599" checksum="F519D449D202E76F" modified="2006-03-21" version="1">MAESAQTEAADEEAGMRDGGMQKQERSSESQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUC8</accession>
    <name>Q2GUC8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_08426</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226353.1">
        <property type="nucleotide sequence ID" value="XM_001226352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUC8"/>
    <dbReference type="STRING" id="306901.Q2GUC8"/>
    <dbReference type="GeneID" id="4394674"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08426"/>
    <dbReference type="eggNOG" id="ENOG502QRZN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005335_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUC8"/>
    <dbReference type="OMA" id="KMYHLSG"/>
    <dbReference type="OrthoDB" id="445341at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
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        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF5">
        <property type="entry name" value="ISOCHORISMATASE FAMILY PROTEIN FAMILY (AFU_ORTHOLOGUE AFUA_3G14500)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="560"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="603"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="641"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ84412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="990" mass="107109" checksum="BC896FC97B7D1279" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVD4</accession>
    <name>Q2GVD4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225726.1">
        <property type="nucleotide sequence ID" value="XM_001225725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVD4"/>
    <dbReference type="GeneID" id="4394538"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08070"/>
    <dbReference type="HOGENOM" id="CLU_1610558_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GVD4"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="165" mass="17926" checksum="274C370B02502DC8" modified="2006-03-21" version="1">MCLEPSNGGIAGQNGIAGFPSRLEEPNLMIIPEILLVGDQESDTCQPYHRANDFPRLCCIHKHGKSDVHQCKSFQGLASTRNTGLAGRRRRFSCRYRRRRAARRRGGRRGVDLGLCMCALHLEIAAGMGRDPLEPLMLDHGNPAAPSNGAAGRQDGDGLAVGRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVL6</accession>
    <name>Q2GVL6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_07988</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225644.1">
        <property type="nucleotide sequence ID" value="XM_001225643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVL6"/>
    <dbReference type="FunCoup" id="Q2GVL6">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="GeneID" id="4393313"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07988"/>
    <dbReference type="eggNOG" id="ENOG502QU4U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_6_1_1"/>
    <dbReference type="InParanoid" id="Q2GVL6"/>
    <dbReference type="OMA" id="MASFEYI"/>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ86735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="338" mass="36361" checksum="53FF120915349198" modified="2006-03-21" version="1">MVCATGEPDWSGVTLETFNLTLLQNPRLCTSCTCPLELNGLHFGVMSYYPSLAGNALFAAIFGLCLLPQIYLGIRHKTWGYLIGMTGGILLELLGYIARILMRDNMFTDSYFIMYLVCLTIAPAFLAAGIYLSLSRLVVIYAPDRARLPAQVYTYIFIGCDVVALVLQAAGGAVASISELGSPALRAGVDTMIAGVAWQVVALALFGVLCLDFWIRVRSTPTSALNPAFADLRAQRSFQPGFLVAMLLTGVFIFVRSVFRCAELSEGFNGPLANDEVTFMVLEGTMIALACILLTVFHPGLVVGGETWLAAGWKAAKRRAAADAEKVRPGTDSGSDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWK4</accession>
    <name>Q2GWK4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225306.1">
        <property type="nucleotide sequence ID" value="XM_001225305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWK4"/>
    <dbReference type="FunCoup" id="Q2GWK4">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="GeneID" id="4393875"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07650"/>
    <dbReference type="eggNOG" id="ENOG502S0SX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044999_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GWK4"/>
    <dbReference type="OMA" id="AGTHEGQ"/>
    <dbReference type="OrthoDB" id="2898509at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="36904" checksum="D91A17BA4354627C" modified="2006-03-21" version="1">MVSLEQIRSSNSKIPTTLRPGLVAVFAGATSGIGESSLRQFAKNAIKPRIYFLGRSKQSGDRVRAELKKLNPDGEYIFISVDVSLLRSVDDVCRQIKEKESAINLLFLSTGSMITGKDTEEGLNYPTAVAYFARLRFVVNLLPQLQNATDLRRVVSVMAGTKEGPINMDDLAGRTTNLFSPSGRGHFCSMMTLSFEAIAKTAPGVSFVHDYPGFVKTNLGNDVKGLTFAIIKAIWGAVSLVIAPLIATPFDEAGERQLFFATSARFPGGDGGAAGVPLPEGVKVAKGSDGKRASGVYSITNHAETAPPKVDQLLEKFRKDGTAQKVWAQVQKEFIRTTGVASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWW8</accession>
    <name>Q2GWW8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225192.1">
        <property type="nucleotide sequence ID" value="XM_001225191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWW8"/>
    <dbReference type="GeneID" id="4393624"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07536"/>
    <dbReference type="eggNOG" id="ENOG502RKT4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_924383_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWW8"/>
    <dbReference type="OMA" id="CENSTVG"/>
    <dbReference type="OrthoDB" id="4587718at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="301" mass="33960" checksum="F1C09E3DBEE33A2E" modified="2006-03-21" version="1">MESIKNSLGLLMATAQFEDRMMGMVGGEDLESNKGLRKEMRRLRRLIKHHLMAMQDLPAPLGHNHYSEREASSDSLDPDLMRKNALIELGWSIYESGRIPISPPISPSSSVPNHSSQPPDTHRRSRRRRRSTTPHPVHLPRQASPEPPDPPVSEIGPVLSSEDFSEPPSDIHKTLRYGKDDVTAVTSGYVTDMNNIADLSRWRQTTASVVESLDGNFISIHKARELNLDIDSPSLTENVMFDFGTGKLERSFGKTTFKWRPWNHADVRYPSLIITCDVCENSTVGLVLGTPFLDERERLWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX79</accession>
    <name>Q2GX79_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_07425</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225081.1">
        <property type="nucleotide sequence ID" value="XM_001225080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX79"/>
    <dbReference type="STRING" id="306901.Q2GX79"/>
    <dbReference type="GeneID" id="4394044"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07425"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="InParanoid" id="Q2GX79"/>
    <dbReference type="OMA" id="MHPGVAM"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ86172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="47273" checksum="329C0E50C2484F77" modified="2006-03-21" version="1">MSDHLLVLIPGQILTASGFTKYLLATLGALFAYLLASYLASPLRQYPGPFLAKFTNLWRTYHIAQGSFHHVLVRLHENSGSSLIDGNIVHTLFSQDDEEKHAAEKKPIAKYYSPASVATLEPLIDETIAQLCSELDKRFAATCGATGKAFDLGKWILYCSVTFSQPLGYLSAGADFDGTLRAAEKIQDYFAWVGCVPFLDRVLEKNRIVQMFKRPGEMNALAGSCVGRLIARYQGADASQESKSQDDDEKKKTPTPTQPQPDYLDRFIEAKSANPTITDGQIVGWLMINMLAGADTTAISIRSAIHLSLRTPGAPVLAFKPRTSSNRNVGVWCADAHAFPTGSDGCTGRGKGEGEFAARLRAMNDADLSFGAGSRMCIGKHLGLMQVYKVVATVVLGYEVELVRPGEELRVVNSWFPRQEGLEVRMVRRGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXF6</accession>
    <name>Q2GXF6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_07348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225004.1">
        <property type="nucleotide sequence ID" value="XM_001225003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXF6"/>
    <dbReference type="STRING" id="306901.Q2GXF6"/>
    <dbReference type="GeneID" id="4393831"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07348"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1304730_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GXF6"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="8"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ86095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="211" mass="23543" checksum="4B6CACBEEB7154E8" modified="2006-03-21" version="1">MTSSLPPDPWKALGIERNADKSEIRTAYKKLVLKCHPDKIQDPTLKALKADDTPPTAPESPPRVSRSHTAPHAVYGTIPSLSRTQTWAPSSNPAPAYYDDIESEDDRDRRRRSRRTRSPSGQSTRYKVDGVKTSKMDPQYSYGESPSSTRRYAADGYIEHLAHSPSSATYSGAQFRVKQTKSYTPDDIMFAHYDQPSYYGPHGGDAYTAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXH9</accession>
    <name>Q2GXH9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224981.1">
        <property type="nucleotide sequence ID" value="XM_001224980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXH9"/>
    <dbReference type="STRING" id="306901.Q2GXH9"/>
    <dbReference type="GeneID" id="4394079"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07325"/>
    <dbReference type="eggNOG" id="ENOG502RJPA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056754_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GXH9"/>
    <dbReference type="OrthoDB" id="3439027at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="405" mass="44323" checksum="BECDB51E5BFFCD13" modified="2006-03-21" version="1">MRESAETAETAEKPRSPSKKKMVTTRQDRVRRDLGVPRLVDSLASFSVFLFTRSICDVNHSGEEGVGQPGHLPFTDLAAYHAASFSVFPPTAIYGRTETSSPPRRLIFLDISRLEVHRMPASRPSAQHLPRDSWLSNPMFLQPSIERDDGEIEDLNLSNMEEDPLMYFLTPAPYSCSGDDGMDFDMEFDAGIEDAKHPAPIVRSVSPSSLEGLSRPPPRPPTPPRSPATPDLDYDLSGTPDEYEQYDYMESSWPPRRGSSMSLPRRLKDKFKVHYPKQDVGYPDSLAPPPPPSPHSPRTSSRGRATSRAAGGGPQQQPGSRRTRAAPARLSPHAWREPSPDVWAIEEEPEAELYTEGGDGSFLGSGPVDIPAANKPKVRFVLPAAVVAVNVGDVGGAVDGRGATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXU9</accession>
    <name>Q2GXU9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 13">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_07205</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="14">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 13"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224861.1">
        <property type="nucleotide sequence ID" value="XM_001224860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXU9"/>
    <dbReference type="FunCoup" id="Q2GXU9">
        <property type="interactions" value="527"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GXU9"/>
    <dbReference type="GeneID" id="4393677"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07205"/>
    <dbReference type="eggNOG" id="KOG2161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007380_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GXU9"/>
    <dbReference type="OMA" id="FNWYNTT"/>
    <dbReference type="OrthoDB" id="410058at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070880">
        <property type="term" value="P:fungal-type cell wall beta-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000027">
        <property type="entry name" value="Probable mannosyl-oligosaccharide glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.110:FF:000003">
        <property type="entry name" value="Probable mannosyl-oligosaccharide glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="17">
        <location>
            <begin position="29"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="16">
        <location>
            <begin position="295"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ85952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="816" mass="92120" checksum="C9C2F76680802AE7" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXW1</accession>
    <name>GET3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase GET3</fullName>
            <ecNumber evidence="1">3.6.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Arsenical pump-driving ATPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Arsenite-stimulated ATPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Golgi to ER traffic protein 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Guided entry of tail-anchored proteins 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">GET3</name>
        <name type="ORF">CHGG_07193</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arsA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224849.1">
        <property type="nucleotide sequence ID" value="XM_001224848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXW1"/>
    <dbReference type="SMR" id="Q2GXW1"/>
    <dbReference type="FunCoup" id="Q2GXW1">
        <property type="interactions" value="877"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GXW1"/>
    <dbReference type="GeneID" id="4394544"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07193"/>
    <dbReference type="eggNOG" id="KOG2825">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040761_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GXW1"/>
    <dbReference type="OMA" id="MDAPYEF"/>
    <dbReference type="OrthoDB" id="1770at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000235">
        <property type="entry name" value="ATPase ASNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000388200" description="ATPase GET3">
        <location>
            <begin position="1"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <sequence length="340" mass="37554" checksum="D3AD013E3BE9A15E" modified="2006-03-21" version="1">MSATLINVDDGDAMEPTLQSILDQRSLRWIFVGGKGGVGKTTTSCSLAIQLAKVRRSVLLISTDPAHNLSDAFSQKFGKEARLIDGFENLSAMEIDPNGSIQDLLAGQGEGDAGADMGGMGGMMQDLAFAIPGIDEAMSFAEVLKQVKSLSYETIIFDTAPTGHTLRFLQFPSVLEKALAKVSQLSNQYGPLLNGFLGSNGTLPNGQNLNEMMEKLETLRATISEVNTQFKDERLTTFVCVCIPEFLSLYETERMIQELASYGIDTHSIVVNQLLFPKPGSDCEQCTARRRMQKKYLEQIEELYDEFNVVKMPLLVEEVRGKERLERFSEMLVTPFVPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYF5</accession>
    <name>Q2GYF5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224655.1">
        <property type="nucleotide sequence ID" value="XM_001224654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYF5"/>
    <dbReference type="STRING" id="306901.Q2GYF5"/>
    <dbReference type="GeneID" id="4394111"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06999"/>
    <dbReference type="eggNOG" id="KOG0855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1928009_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYF5"/>
    <dbReference type="OMA" id="FAMFALH"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="108" mass="11184" checksum="E667370BCADD8D03" modified="2006-03-21" version="1">MPMELRKRKEAPAPPPAPARKKTTKTTKAASTATKVKEAVKEKVAAAVASTNGSSDTAKPAVGDTINLDGFCGEIETHDGTKTTLKALVDESEAGVVLFTYPKASTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYS6</accession>
    <name>Q2GYS6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224534.1">
        <property type="nucleotide sequence ID" value="XM_001224533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYS6"/>
    <dbReference type="GeneID" id="4393884"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06878"/>
    <dbReference type="HOGENOM" id="CLU_3242085_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYS6"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="43" mass="4456" checksum="3926C4133A6B5EAC" modified="2006-03-21" version="1">MSVSQLLRRSGGLGNATPLSRSRGRGGGQDIVSDKLVGTIKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYT9</accession>
    <name>Q2GYT9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224521.1">
        <property type="nucleotide sequence ID" value="XM_001224520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYT9"/>
    <dbReference type="STRING" id="306901.Q2GYT9"/>
    <dbReference type="GeneID" id="4394090"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06865"/>
    <dbReference type="HOGENOM" id="CLU_1855042_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYT9"/>
    <dbReference type="OMA" id="CNELAEY"/>
    <dbReference type="OrthoDB" id="4961408at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47611:SF1">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47611">
        <property type="entry name" value="HAT DIMERISATION DOMAIN, C-TERMINAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="54"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="138" mass="15691" checksum="8363DC4592F5D1A5" modified="2006-03-21" version="1">MPPSVASVADTDLSTELLTVQTSSDRTLITTAAVAAPHRHTFYARRPDPATRDELQAYLCEEPQEIHDAVEWWLSPGRRSDFPRLSIMALDLLTIPAMSSECERVFSRAKHTVAHQRHRLDDDAINIVESLKQWSRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYZ9</accession>
    <name>Q2GYZ9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein Rad26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_05247</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224461.1">
        <property type="nucleotide sequence ID" value="XM_001224460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYZ9"/>
    <dbReference type="STRING" id="306901.Q2GYZ9"/>
    <dbReference type="GeneID" id="4392769"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05247"/>
    <dbReference type="eggNOG" id="ENOG502RZ1G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013058_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GYZ9"/>
    <dbReference type="OMA" id="EMAHEML"/>
    <dbReference type="OrthoDB" id="5245063at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048379">
        <property type="entry name" value="Rad26-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022093">
        <property type="entry name" value="Rad26-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048380">
        <property type="entry name" value="Rad26-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21046">
        <property type="entry name" value="Rad26-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12331">
        <property type="entry name" value="Rad26-like_helical_rpts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21048">
        <property type="entry name" value="Rad26-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad26-like N-terminal" evidence="4">
        <location>
            <begin position="369"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Rad26-like helical repeats" evidence="2">
        <location>
            <begin position="475"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Rad26-like C-terminal" evidence="3">
        <location>
            <begin position="774"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ88628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="838" mass="92068" checksum="6E67887DD0F67C84" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZ17</accession>
    <name>Q2GZ17_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LYR motif-containing protein Cup1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224443.1">
        <property type="nucleotide sequence ID" value="XM_001224442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZ17"/>
    <dbReference type="GeneID" id="4393104"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05229"/>
    <dbReference type="eggNOG" id="ENOG502S9TZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037437_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZ17"/>
    <dbReference type="OrthoDB" id="5521299at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20273">
        <property type="entry name" value="Complex1_LYR_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046896">
        <property type="entry name" value="Cup1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20263">
        <property type="entry name" value="LYRM2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYR motif-containing protein Cup1-like N-terminal" evidence="2">
        <location>
            <begin position="16"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="251" mass="28604" checksum="44643737266C9859" modified="2006-03-21" version="1">MSQPLRIPKPETALHLYRHILREASYLPPLARRPIDKQIKDKFRRNQDHEDKTAKYLRQAHHDLRALRAANAGDMGRMRRVLLRAFGRIGRRRRELISQLVHRDTPANTEELEKYAIAMADIGAKNNTPDWMDDWDLDKLRALARSQAQATLVNTPKATVTENQAAPEKNLPKENSWGRPLPLKLARTKLKNLWKALADKVLPPLPMEEWKKLEAIANGTVVGDWLPPPRRHTLSNPSPLSTGKPTGGTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H050</accession>
    <name>Q2H050_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_04846</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224060.1">
        <property type="nucleotide sequence ID" value="XM_001224059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H050"/>
    <dbReference type="STRING" id="306901.Q2H050"/>
    <dbReference type="GeneID" id="4391877"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04846"/>
    <dbReference type="eggNOG" id="KOG0866">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044364_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H050"/>
    <dbReference type="OMA" id="LFKGMRC"/>
    <dbReference type="OrthoDB" id="185618at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF142">
        <property type="entry name" value="RAN-BINDING PROTEIN 3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="4">
        <location>
            <begin position="302"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="268"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ88227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="449" mass="48167" checksum="15BC6385E18CF415" modified="2006-03-21" version="1">MADDPHNTSEISDHAEPAAVVAKEDAETTAARRELKQTTISEKRGRDAVQLSQDDKSASEDEGPKSKSRRLTPPISLSASSDDMLKAQISSPKKKRAHDEVDENKDVAEAPLGGTPNKAASPTTVPNRTNRSEPEKKRPRDRQASASAVQGGKEEVPRQPRRLVASAAQENPACLVRRRGPPPWAVFSAAPSRPPPSAPPKLSFGGAAASSPFAGLNGQSTTGSVFKSSPFASALGGSALSGPRINFGKPGEVLKSDKPAKPFGAPDSDAEDKSEEESNEDEDAKGDASSDDEAKEEDGDREASKGAEEKKKPKLQKSKRARPSIDVGWKERGGGMLKINVPKSTVDLDDNGVPDPTSFDASVLADEDDDQLKHVRLIMRQDHTLRVILNTVLLPAMKFQVTNRLKTSTVGFTAFEEGVGRQVQMKLSEVNATAFSQIIEMLKKRLADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0A6</accession>
    <name>Q2H0A6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_04790</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="3"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224004.1">
        <property type="nucleotide sequence ID" value="XM_001224003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0A6"/>
    <dbReference type="STRING" id="306901.Q2H0A6"/>
    <dbReference type="GeneID" id="4392430"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04790"/>
    <dbReference type="eggNOG" id="KOG2245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_324153_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H0A6"/>
    <dbReference type="OMA" id="THGPPDQ"/>
    <dbReference type="OrthoDB" id="10263155at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09080">
        <property type="entry name" value="TDP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF23">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase central" evidence="10">
        <location>
            <begin position="651"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="595"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="869"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="599"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="876"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ88171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="891" mass="96498" checksum="95552E030FA12238" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H160</accession>
    <name>Q2H160_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223700.1">
        <property type="nucleotide sequence ID" value="XM_001223699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H160"/>
    <dbReference type="GeneID" id="4392695"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04486"/>
    <dbReference type="eggNOG" id="ENOG502QU2T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H160"/>
    <dbReference type="OMA" id="EGHYNAI"/>
    <dbReference type="OrthoDB" id="2310150at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="329" mass="35997" checksum="B33689D21CB5715F" modified="2006-03-21" version="1">MASARQPPQIVLGTHTIGDVTALPGIIHIDKVEEVQALLDVFYNRGYRTIDTARNYVGSENRLGQAGAASRFTIHTKVLDGTPGSHESAKIEASIKQSLADLRTPSTESMFLHVPDRQTPFEDAAAAMNKAFHEGKFKKFGLSNYTAKEVQQFVDICEEKGYVKPSIYQGNYNAIMRGGEKELIPLLRKHNISYFAYRQNNHSPGAGGLFSGSAGNSTASTRWSNDNPVGKRALEFYTRPSTDDAVAAVRRAAEKHGVSGHAAALRWTTYHSQLDGKYGDAVVFGVRTMQQLEQSLDAFEAGPLPDELADAITAVYKSFEGGEEPTFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1I2</accession>
    <name>Q2H1I2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_04364</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223578.1">
        <property type="nucleotide sequence ID" value="XM_001223577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1I2"/>
    <dbReference type="GeneID" id="4392115"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04364"/>
    <dbReference type="eggNOG" id="ENOG502SJFM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_3_0_1"/>
    <dbReference type="InParanoid" id="Q2H1I2"/>
    <dbReference type="OMA" id="QCSPPAY"/>
    <dbReference type="OrthoDB" id="3923077at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF93">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
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    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
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            <begin position="89"/>
            <end position="111"/>
        </location>
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        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
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        <location>
            <begin position="27"/>
            <end position="117"/>
        </location>
    </feature>
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        <location>
            <begin position="260"/>
            <end position="350"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ87745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="387" mass="41372" checksum="9D93DED9EFD74FD2" modified="2006-03-21" version="1">MAMGGQGPWAVAVMWVVTVVAFVFVILRAYTRIKVVQSYGVDDHVYNFAFLLLVCYTAATTVSAHYGFGQRVADIGDLDDLANTILFEAIGQTFAVVGMAVAKWSLGLFLLRWFLPYQHDPCLVYFVHPLRYSRFLFRIIPLAVSLAAADEPTRKDGHRNKSELGDTCSAGACGIKRTVEVPSLSSADYPCKHPLPPSCRCRLNDPLLTLGHKTDDTVGLIVWSAAEIAVTMICIGIPICRPLYKQWLDRVLSYGSGIGSGGYQKQKGQGQSGEINSHRGFGLRTFGGSTMPGRAHRSAEPNAAPDSSSDIASDTDSKDGAGGAGAVGSSGQTHKRGPPGDNLGAGAPFHEATVVGGLEWNGSEEEILGADSRGGGRHERCRVREGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1K6</accession>
    <name>Q2H1K6_CHAGB</name>
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        <recommendedName>
            <fullName evidence="11">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="11">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
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        <name evidence="14" type="ORF">CHGG_04340</name>
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    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
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    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
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            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the phage and mitochondrial RNA polymerase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EAQ87721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04340"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-EC"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNA_POL_PHAGE_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
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    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase N-terminal" evidence="13">
        <location>
            <begin position="362"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
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            <end position="330"/>
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    </feature>
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    </feature>
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        <location>
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        <location>
            <begin position="1324"/>
            <end position="1345"/>
        </location>
    </feature>
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        <location>
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            <end position="319"/>
        </location>
    </feature>
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        <location>
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            <end position="548"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009493"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003805"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ87721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1414" mass="157198" checksum="57F3C9C5384AD398" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1Y7</accession>
    <name>Q2H1Y7_CHAGB</name>
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        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">CHGG_04209</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ87590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_001223422.1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="392"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="544"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="579"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="596"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ87590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="866" mass="92968" checksum="00ACAF138C6F90A6" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H267</accession>
    <name>Q2H267_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_04129</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223343.1">
        <property type="nucleotide sequence ID" value="XM_001223342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H267"/>
    <dbReference type="FunCoup" id="Q2H267">
        <property type="interactions" value="308"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H267"/>
    <dbReference type="GeneID" id="4391631"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04129"/>
    <dbReference type="eggNOG" id="KOG1750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104295_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H267"/>
    <dbReference type="OrthoDB" id="361013at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000099">
        <property type="entry name" value="Ribosomal protein S12, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ87510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="15071" checksum="0E82DA1FC667D888" modified="2006-03-21" version="1">MATAFLRNIVLRPALRPTLAKSTTPTPTPIARAFSTTPSQSATLNQVLRVGITKPKKPNSGERKTARVRLSTGKVITAYIPGEGHNIQQHSVVLVRGGRSQDCPGVRYHLVRGALDLGGVGSRMSSRSKYGTKKPKKASVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H296</accession>
    <name>Q2H296_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223314.1">
        <property type="nucleotide sequence ID" value="XM_001223313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H296"/>
    <dbReference type="STRING" id="306901.Q2H296"/>
    <dbReference type="GeneID" id="4392065"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04100"/>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054420_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H296"/>
    <dbReference type="OMA" id="ANEWALH"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF3">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G09070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208832" description="Carboxylesterase type B domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="162"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="362" mass="38723" checksum="E22C6781D174EE61" modified="2006-03-21" version="1">MGLLGRLPALAAVAAAFSITTAEASYAGGGLTILAPSDVDGSENDGSAAILVGQPADFETGRATCKLLAEAPWSPEQADFESTLSKALGYQEYQDLAPKDQLYWVSKVKSCKSACRAIDTQGKTHAVKCDEELPILCTHSAPLSSSTSDNTSTTWQVQQTVGKKVLTGYRDYHVWKFRGVRFADTPARFTYSKAASYEDEGEVDALLAGEDCPQTVEDAEGGTSSEDCLFANVWTPYLPPTGGADKKELKPVMVYIYGGAFTSGSSKNAYKDGTNLAARGDVVVIAFNYRLGSIGFLNLNDGVHNGNYGISDQVTALEWISKYIKYFGGDPDRVTIFGESAVARASICSFGIEKAKRLFHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2M7</accession>
    <name>Q2H2M7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_03969</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223183.1">
        <property type="nucleotide sequence ID" value="XM_001223182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2M7"/>
    <dbReference type="GeneID" id="4392530"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03969"/>
    <dbReference type="eggNOG" id="ENOG502S63H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024893_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H2M7"/>
    <dbReference type="OMA" id="QIDPRMD"/>
    <dbReference type="OrthoDB" id="2537459at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF31">
        <property type="entry name" value="WSC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208863" description="WSC domain-containing protein" evidence="7">
        <location>
            <begin position="26"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="34"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="127"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="127"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ87350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="331" mass="35035" checksum="7440B9F4F4A79816" modified="2006-03-21" version="1">MAPARIAPTWANLGIAALLSGMAWAQQETPQGPSIPLEYCSTVNTGDMVPLYYDWQSEGRCFGNCTSLKYALAIIQEKNCWCSNLIPNRADRKPLEDCQFPCPGYPTDYCGGGGVFAYLEAAGGNPTGTAPPGGSATKSPSSTTSESVSKPPSVTTITVGGTVRTVTAPTEPTASNDSSVVENEGSSLQPGAIAGIVIGVVGGLAIIAAAVWFCFFRRRKEDEGPNNGLGSPIRGGGSPGRMATPNSGEVSENRYAGTTGGSVAGTWDSQNKRRSHLMPVDPRLDPFATGIYPDQNRSRESFNSLQDNQDYSRRVHQPPRVLRAMNPDPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2W4</accession>
    <name>Q2H2W4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocation protein SEC62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_03882</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223096.1">
        <property type="nucleotide sequence ID" value="XM_001223095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2W4"/>
    <dbReference type="FunCoup" id="Q2H2W4">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H2W4"/>
    <dbReference type="GeneID" id="4391608"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03882"/>
    <dbReference type="eggNOG" id="KOG2927">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040936_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2W4"/>
    <dbReference type="OMA" id="WGWQETK"/>
    <dbReference type="OrthoDB" id="200187at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004728">
        <property type="entry name" value="Sec62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011553">
        <property type="entry name" value="Sec62_asco"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00869">
        <property type="entry name" value="sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443:SF9">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03839">
        <property type="entry name" value="Sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="272"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="347"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="347"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ87263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="394" mass="44359" checksum="B34ED9BA0538A47E" modified="2006-03-21" version="1">MQAPPPQGPPQGGQMPMMPSPEQIAHMQRQLAIDAEKMGMTVPQFIEHLKRQAQERMQAQQQQQQQQGQEGEHQHQHQHQHQHPHPHQHQHQHPPQGQQQPIVPGPPNPVAIALAKFLRSQTLKPRTCILNGERKDMFRVKRALRALQSDAYKAARKKNPALPEITDRASLENTFKLLPLSMLALRVVKSDPHEGHDHGPPAKKQGKRTKGLWTVRIEPQQEAGDDMYYVWLWEGSQVMRKVYAALALAAIFAVVCYPLWPVKLRQGGYYLSWAFLCFMGLFFAMAIFRVILFCITYFVLSPGFWLFPNLWEDVSVVDSFKPVWAWHEPAAAKKKKKSKKSASGSAAAGATFSGATGQPAPASATTTATSTQISTGPQQRNYMAPRVEELEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2Y7</accession>
    <name>Q2H2Y7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223073.1">
        <property type="nucleotide sequence ID" value="XM_001223072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2Y7"/>
    <dbReference type="GeneID" id="4392086"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03859"/>
    <dbReference type="eggNOG" id="ENOG502ST7N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1026720_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2Y7"/>
    <dbReference type="OMA" id="WASSSWI"/>
    <dbReference type="OrthoDB" id="5287295at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="271" mass="29756" checksum="6E5D7AB11DB07D0C" modified="2006-03-21" version="1">MSAEAIHTIIRWRDIKLEQYENLVKNVGNPELNITGGSTGLDLVLFYIQYYSYNVESLLVFFWAVELANSIFQLRITKIYRFHASLVAKATAAFLPVVQMILLRFSGVDKSTVGFMALADAIMIGCFAAGSIMLLAILIRYVHSRITLASWNVRYIHGTSSKSGGTNATPSGRGRAPKKTIYDKWLVLRFTVAFAALSLFQIVVINFQLRAAATNTRANLPPHPDLSAARARGDIALFAPPPRPPCCSPSSSLAPPAPFANTPGPCWRRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H364</accession>
    <name>Q2H364_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_03782</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NOP53 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222996.1">
        <property type="nucleotide sequence ID" value="XM_001222995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H364"/>
    <dbReference type="FunCoup" id="Q2H364">
        <property type="interactions" value="544"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H364"/>
    <dbReference type="GeneID" id="4391624"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03782"/>
    <dbReference type="eggNOG" id="KOG2823">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035888_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H364"/>
    <dbReference type="OMA" id="TEKWTHK"/>
    <dbReference type="OrthoDB" id="5072at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017302">
        <property type="entry name" value="Gltscr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="219"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="237"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ87163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="381" mass="43696" checksum="3A2C79137A45B187" modified="2006-03-21" version="1">MPVLKPLSGNPDAPQQYKQPSRKGKKAWRKNVDISEVQQGLEELTGQIIKGGVIAEKDSAELFTIDVEGDAELPKRFSKHVKKGLKADEIIAQRSAVAAVPMRKRAGDKTTDGILPVKRQRTTYITHKELTRIKKVADGHHESTVAVVDADYNSAFSDYQERLIEESEKAVEAERKRLEAVEAERIKMEAAARSAAEAEAAEARADLSEWEDDSAWEGFESAGEEMSVKTKRPRRKTQAERNKIKRRKEEERKAKHEAAMKRRRAQEERIKQIALEVAEKERQMELEKVEMSDGSDDDGNEIELRRRQLGKLKLPEKDLELVLPDELQDSLRLLKPEGNLLKDRYRSMLVRGKMEARRKIPFKKQARSKITEKWTYKDFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3B2</accession>
    <name>Q2H3B2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222948.1">
        <property type="nucleotide sequence ID" value="XM_001222947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3B2"/>
    <dbReference type="ESTHER" id="chagb-q2h3b2">
        <property type="family name" value="Hormone-sensitive_lipase_like"/>
    </dbReference>
    <dbReference type="GeneID" id="4392187"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03734"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_6_4_1"/>
    <dbReference type="InParanoid" id="Q2H3B2"/>
    <dbReference type="OMA" id="QWLIYPR"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="103"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="349" mass="38662" checksum="D45E189974457158" modified="2006-03-21" version="1">MTSMQSRIHVPAAGTRAASLNREVARFLDNHQDLTLGSAEWYDVERQKHAEVFALKNLPKRKVNPIGTVEFTTVRGPHGDIPIRVLYPENGRDLRTSGDAGALVYCHGGGYCVGSVDEFENGLRLIAEESGCMVFAVEYRLAPELRYPVQLDEYSAVVDWVQGDGGRYRGVHPRRVAGGGDGVGGSMTVALCFRRRTLGLKPLAAQLLLYPALYSPCLDPQEDEGEPGYYTQDKGIYSCNIHYLPLTAGLPRPMEYVYPGEQGSSGLIGQPPAAILTNGFDPLREGGIRFARKMNNIELLAAWKHYGDLAYGWLQMTPWSEAAREATCDAGVELRRLLYKRDIEEKPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H469</accession>
    <name>Q2H469_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MAGE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_06546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222641.1">
        <property type="nucleotide sequence ID" value="XM_001222640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H469"/>
    <dbReference type="STRING" id="306901.Q2H469"/>
    <dbReference type="GeneID" id="4390627"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06546"/>
    <dbReference type="eggNOG" id="KOG4562">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048908_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H469"/>
    <dbReference type="OMA" id="GMQMVEQ"/>
    <dbReference type="OrthoDB" id="205198at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1200">
        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041898">
        <property type="entry name" value="MAGE_WH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF14">
        <property type="entry name" value="NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="2">
        <location>
            <begin position="74"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="348" mass="38460" checksum="F81163B37EF77B94" modified="2006-03-21" version="1">MPAQQRRRPPVGLDLTEKGWKESQTDRKQAVPESDDEDMQHEHSNIPDDVDGDGDEQMADGGQRDETSHLIKSLVRYALACEYSRTPIRRDVLGSNGREFKKVFAGAQKQLQATFGMEMIELPTKDRNLLTTEQKRKAAKSQSQKEPTSNAYVLVSTLPETFTTPAIITASKVESAEGEASYIALYTTIIAIIMLSGGELSDPRLRRHLSRLNALENMPSMNPHNGASPNEKTDSVLQRMIKQGYLVRVTESGSMGDDDGTTWHVGPRGKVEVGKDAIAAFVRTIYGGSNEELESKLQVSLKTRGRVTSMSEVIEEGAEAAPPDGDPGSSTRRRGRRRRTEAQDEESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4M0</accession>
    <name>Q2H4M0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_06395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222490.1">
        <property type="nucleotide sequence ID" value="XM_001222489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4M0"/>
    <dbReference type="STRING" id="306901.Q2H4M0"/>
    <dbReference type="GeneID" id="4390110"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06395"/>
    <dbReference type="eggNOG" id="ENOG502S8N8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041953_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4M0"/>
    <dbReference type="OMA" id="NTEMMTS"/>
    <dbReference type="OrthoDB" id="4151048at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ89776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="382" mass="41783" checksum="A629E4558EBAE11C" modified="2006-03-21" version="1">MDSLPTPPNEEHARPQGLKRSHAASKPLKTVHRTLKRTSTHSHPPSPARESHSQHGDGRHKRVWKACERCRMKKTKCDGEFPCKRCKDDGLICTAGTRKKTEYKQLPPGYAEVLENTQFVLIATVQKLYSMVRNGEPWELGEPELNDRGQPVIHNVAAKLGCLRPNTDLDLPIHSIFPEDEAGMTELARQLQDHAAASTTTTTGTTSQGSGSSRQETESNGIYNRTDRASSSAASDAEHSDLDHEPDYRRAAFGAASAVSMSPASLGYPDFEISPPSAAPSDGFPPSQHSPTVPVHPHNFQWMGRPSSMDFTTQQLWMASQGFMNTEMMTSGVLGSTYATKPAGFSSSCRNPEVMMGMGDPVIFSSGYEEDKLGPLFPNSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4T7</accession>
    <name>Q2H4T7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">O-methyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_06328</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222423.1">
        <property type="nucleotide sequence ID" value="XM_001222422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4T7"/>
    <dbReference type="GeneID" id="4389940"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06328"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_1_4_1"/>
    <dbReference type="InParanoid" id="Q2H4T7"/>
    <dbReference type="OMA" id="SIIEAVW"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF16">
        <property type="entry name" value="O-METHYLTRANSFERASE ELCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="276"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ89709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="472" mass="51978" checksum="72F5F93AD0EC47CA" modified="2006-03-21" version="1">MSRFRLSSLFQSSSPASTDTEVKKQNRRSFSALSSSLRQKDAEANGAPAPAPKVAAAETASEQSPSRMVALARQITQATEKLEAYMKANNLPMPSFDPGQFLDVLSLTIINHYKLAQLVPIDSTIQLAELETKTTLDRINLARILRLAMTNGIFREPSPGVIAHTAASRVLAEDEDMQAWVGFNGEDIFRAAGHVLQSLKADPEATSLTRAGFQFAFDTVDKEPMFATFGKDPERARRMGRAMASLTGGEGYEPAYFVDVEKGGYDFSDLDAAGGTFVDVGGSHGFICVALAERYKNMKFVVQDLQKTVDSAPKPLSADPQVAERISLVAHDFFAEQVTKDADVYFFRWIMHNYSTPYAIRILKNLVPALKPGARVVINDYCLSTPGKENPWDERVVRRMDVVMLAVLNAQERTEREFRELFRAAGEGFVFKGVRRAKGCRMSVIEAVWKPDEVVKKAEETAAPATVADASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4W0</accession>
    <name>Q2H4W0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_06305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001222399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4W0"/>
    <dbReference type="GeneID" id="4390406"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06305"/>
    <dbReference type="HOGENOM" id="CLU_3224501_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4W0"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="44" mass="5144" checksum="32C3839F34390117" modified="2006-03-21" version="1">MASDCFGQPQKEARRVGVTLASFWSLLRDMSRRAQERLSEWDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5N0</accession>
    <name>Q2H5N0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">O-methyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_06035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222130.1">
        <property type="nucleotide sequence ID" value="XM_001222129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5N0"/>
    <dbReference type="GeneID" id="4390435"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06035"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_1_4_1"/>
    <dbReference type="InParanoid" id="Q2H5N0"/>
    <dbReference type="OMA" id="WKEVITQ"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF16">
        <property type="entry name" value="O-METHYLTRANSFERASE ELCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="231"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ89416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="406" mass="45339" checksum="A6415F9102667CAE" modified="2006-03-21" version="1">MASPEPRIVELAKRIAANTETLQSYLTSHNLPTPSFDVDGPKDTLVSKTETETEAARVAIVDDTEELRRLVLGPREYLMSYTHNELLSQQAIARFRLAHAFAPGAEASFADIAAATGLPEINVRQIIRHAIIKDIFVEPRPGVVAHNAVSRLLAEDPVIHDWVGASNDDLWQGAAQTCNALEKYPGSQEPNETFPERARRFGNAMRSFTEGTGFELSHVVDNLPWGEVGNGTVVDVGGSQGFACFAIARKFPALSFVVQDLEPVIQAAEKEVPNDLVDRVRFMTHDFLLEDQPVKGGDVYFFRWILHNWSDKYCVKILRGLIPALKPGAKIVLNDNVLPQPGVLSRWQENRLRSMDLCMTELQNSHERELDDWAKVFELADPRFEFKGGQQPAGSNLWLMVAEWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H619</accession>
    <name>Q2H619_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Yippee/Mis18/Cereblon domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221991.1">
        <property type="nucleotide sequence ID" value="XM_001221990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H619"/>
    <dbReference type="STRING" id="306901.Q2H619"/>
    <dbReference type="GeneID" id="4390151"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05896"/>
    <dbReference type="eggNOG" id="ENOG502SJVM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041705_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H619"/>
    <dbReference type="OrthoDB" id="5396360at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="148"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="260"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="35748" checksum="A175F8CDBBB346C7" modified="2006-03-21" version="1">METIFCECKKCDAAIGRFANLWTQIGKSYFSPVIEPEDDLAVQYLDTVRIGEQDTLVAECHLQDMLCSGCAALLGLRCVQTPVNHVLDRNQILLRLASVELLNGDGQEIEFAIKRVLAVNEPAKENKSKAPESPRGGFTSAFSGIAELQQLQLDLHNQREDIKRIDTNGFRIVTALDKRANRMQGEVAKLRGTVPNLQRAIESIRQELGTVLVDISKAQATDQNPTALLAFEDRLVRVTTSVGEVGEQVATSNARFDKEIGELKWNLGQQEQELENLRGTIRGYAEDMASLRAEVAHMGRQGRTVRDGQTGVRRQPIHSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H620</accession>
    <name>Q2H620_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_05895</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221990.1">
        <property type="nucleotide sequence ID" value="XM_001221989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H620"/>
    <dbReference type="FunCoup" id="Q2H620">
        <property type="interactions" value="195"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H620"/>
    <dbReference type="GeneID" id="4390150"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05895"/>
    <dbReference type="eggNOG" id="KOG2248">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008679_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H620"/>
    <dbReference type="OMA" id="HKAGPPF"/>
    <dbReference type="OrthoDB" id="206335at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000019">
        <property type="entry name" value="RNA exonuclease NEF-sp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="296"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="566"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ89276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="697" mass="76469" checksum="76DDE9C15BD2793B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6N5</accession>
    <name>Q2H6N5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221775.1">
        <property type="nucleotide sequence ID" value="XM_001221774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6N5"/>
    <dbReference type="GeneID" id="4390366"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05680"/>
    <dbReference type="HOGENOM" id="CLU_1651955_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6N5"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="160" mass="17741" checksum="203A2168F04CFD4B" modified="2006-03-21" version="1">MHHTTLNPPRQKRQRAPRMRQHHPQPPHRVKHPGQKHPRHRNGRLHREPQRQRQHVAVGAVAEDGRREPVVRVQEDGQRGGGQRAEDGEQGRVVESLVGGEPAGAEDDAAAVGEGGEVGDGGEDGGGWGEVERGVEEPRYLTGQVRVHHRKAYRATQISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H702</accession>
    <name>Q2H702_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_05563</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221658.1">
        <property type="nucleotide sequence ID" value="XM_001221657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H702"/>
    <dbReference type="STRING" id="306901.Q2H702"/>
    <dbReference type="GeneID" id="4390008"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05563"/>
    <dbReference type="eggNOG" id="KOG4159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013989_3_0_1"/>
    <dbReference type="InParanoid" id="Q2H702"/>
    <dbReference type="OMA" id="PWWFASV"/>
    <dbReference type="OrthoDB" id="264917at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF42">
        <property type="entry name" value="LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN C14F5.10C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="210"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ88944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="528" mass="59753" checksum="BF4D6C01CE41DBC1" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7Z7</accession>
    <name>Q2H7Z7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230173.1">
        <property type="nucleotide sequence ID" value="XM_001230172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7Z7"/>
    <dbReference type="GeneID" id="4388508"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03657"/>
    <dbReference type="eggNOG" id="ENOG502T9XB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_677932_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7Z7"/>
    <dbReference type="OMA" id="IICATEE"/>
    <dbReference type="OrthoDB" id="4775210at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="46021" checksum="1796AE5F243F13D5" modified="2006-03-21" version="1">MYCVQTHDNEVFESTVDVPVARGVEFDPLGSPGLPSLPDEFNNPTPDEPPLFPPPPTTPASIPPPQQTAVANNNKKKRKAAIPKSAPTKVVFSKEMTAQVMLWFNECRKKGMFNSSKKKDYGPIWQEVFERCQEQWPRFPWKPNIIATKYDTERQRYQQWKMLVDGYSGVTFDYTANLPCVSESTWEQFVLRNNTLSKSVTWLRTIPLGDVDVYRSVFWRERASGNHIAEADDAADTQATDVVEEELEEDSNRDVPVMLDTESDEDDDNVAAVTPIQKKRKLTSAQQHRIRTDPNLTPTRGSTPSTVDVPVRHSSHRRDRERDSSILAASFKDSITILAAPRLAGADDVALATEDIQKLFADKVDGSELLNYIDYLQRNPMSAVMWNKLSLALKRLYIDRWKEGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H863</accession>
    <name>Q2H863_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230107.1">
        <property type="nucleotide sequence ID" value="XM_001230106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H863"/>
    <dbReference type="GeneID" id="4389731"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03591"/>
    <dbReference type="eggNOG" id="ENOG502TFWA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_609714_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H863"/>
    <dbReference type="OMA" id="AHFYHAY"/>
    <dbReference type="OrthoDB" id="5391787at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="449" mass="49685" checksum="1A0A2862726E2F6E" modified="2006-03-21" version="1">MQEANEPRTAPLHDPRGLLLYDLRGPLLGGRRTTGKIPLRLSGRPGVSWLPWVKSDCSMSDIMLDQFRGALDNQPLVQQHLHEEAIYYDLNLLPVGAAPEPYATAVANTSTTSPNWPQDDIENIYTGLHRCVDQVVATISVRGSPRLDQIKEQNRKVMDKLRRLESAITGNTAAAASDAVSTPWSPLVHDPDRPRTNPDKRRRVSLPKGPNPTPRATSNSVGAETGRPSMTHITQQKTPGANSNPRIQSHGTGTPRPLFSGLDGDSKLARKLQRIGAEEARAQVTEFAAQLRAPERQNALPTIRQFSNVSQMADASHFRQLVQGLGVAIESSIFGEQNSRIRKRIALAHFYHAYALAQEYPTLFLSWCDDQRVQAGSMLPKGGSRSVVQHRFADLIFPPDEGQDAASDAKRKTLKIQMWRKSGKKWAQMIDRLGYGILLLLPASLSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8B0</accession>
    <name>Q2H8B0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_03544</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230060.1">
        <property type="nucleotide sequence ID" value="XM_001230059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8B0"/>
    <dbReference type="STRING" id="306901.Q2H8B0"/>
    <dbReference type="GeneID" id="4388452"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03544"/>
    <dbReference type="eggNOG" id="KOG0710">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H8B0"/>
    <dbReference type="OMA" id="PIWQPKF"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="57"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="113"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ91609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="245" mass="27416" checksum="48C76AC03DC56495" modified="2006-03-21" version="1">MMHTFPASFCAPQAAEPRFFPLFRLLSDFDNYSQEGRGVSISPAPASRQQRVKQARPQPITVHPRFDVRETEEAYELHGELPGLERENISIEFPEHQTIVISGSVERNYASDATKDNATHEEPTPSEAETETEKPRRNSHQATVEDDPEDENTPASSRDSSPWMDVAKPVARAAAEETTQTPAQTPKDQSKYWLRERSVGRFSRTITFPARIDEDNATATLKNGILSITVPKAKVSTPTRIQITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8E9</accession>
    <name>Q2H8E9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CHGG_03505</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2005-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Giovannoni S.J."/>
                <person name="Cho J.-C."/>
                <person name="Ferriera S."/>
                <person name="Johnson J."/>
                <person name="Kravitz S."/>
                <person name="Halpern A."/>
                <person name="Remington K."/>
                <person name="Beeson K."/>
                <person name="Tran B."/>
                <person name="Rogers Y.-H."/>
                <person name="Friedman R."/>
                <person name="Venter J.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 148.51</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2006-02" db="EMBL/GenBank/DDBJ databases">
            <title>Annotation of the Chaetomium globosum CBS 148.51 Genome.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Birren B."/>
                <person name="Lander E."/>
                <person name="Galagan J."/>
                <person name="Devon K."/>
                <person name="Nusbaum C."/>
                <person name="Ma L.-J."/>
                <person name="Jaffe D."/>
                <person name="Butler J."/>
                <person name="Alvarez P."/>
                <person name="Gnerre S."/>
                <person name="Grabherr M."/>
                <person name="Kleber M."/>
                <person name="Mauceli E."/>
                <person name="Brockman W."/>
                <person name="Rounsley S."/>
                <person name="Young S."/>
                <person name="LaButti K."/>
                <person name="Pushparaj V."/>
                <person name="DeCaprio D."/>
                <person name="Crawford M."/>
                <person name="Koehrsen M."/>
                <person name="Engels R."/>
                <person name="Montgomery P."/>
                <person name="Pearson M."/>
                <person name="Howarth C."/>
                <person name="Kodira C."/>
                <person name="Yandava C."/>
                <person name="Zeng Q."/>
                <person name="Alvarado L."/>
                <person name="Oleary S."/>
                <person name="Untereiner W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 148.51</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230021.1">
        <property type="nucleotide sequence ID" value="XM_001230020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8E9"/>
    <dbReference type="FunCoup" id="Q2H8E9">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="GeneID" id="4388989"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03505"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1911">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_263154_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8E9"/>
    <dbReference type="OrthoDB" id="1918685at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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</entry>
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                <person name="Untereiner W.A."/>
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        <source>
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    <sequence length="258" mass="27818" checksum="ABF42E70566E4DB7" modified="2006-03-21" version="1">MDQRGAPEFILEAFADPNSVRDVVRGILHTIFFLRFFSAVSPQTRDVLGLELAYVPEAEIETLIDQRVAALVRQLESERHQPHNLYDNRGGGPGLGLLGGGTPPSTTSSGGGGGGRGQITIQFLEKRRRKTWYAMRGDDEVCWESWTVKVTVADPRTEGERAKVRRASEKTLHNTIMKAVTLANAHKDHIPPITTSDSNPFPYQIHVSGAGGTGGGSGGGQPQPQPQQQQQHKLSKEGNVAAAAAAAATGWATRMGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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        <property type="nucleotide sequence ID" value="XM_001229759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H960"/>
    <dbReference type="STRING" id="306901.Q2H960"/>
    <dbReference type="GeneID" id="4388619"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03244"/>
    <dbReference type="eggNOG" id="ENOG502SNG2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024747_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H960"/>
    <dbReference type="OMA" id="PYRCKVE"/>
    <dbReference type="OrthoDB" id="5062908at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059009">
        <property type="entry name" value="Znf_C2H2_17_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059095">
        <property type="entry name" value="Znf_C2H2_17_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26177">
        <property type="entry name" value="zf_C2H2_17_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26176">
        <property type="entry name" value="zf_C2H2_17_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="339"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="493" mass="54551" checksum="89BFEF14302A7657" modified="2006-03-21" version="1">MLPSNASGMFSFCQTGPADLAGSSWDATVEGSQNFPELADAADYYTGETEDFVLPFGQNTPKPDHLDASDDFQARWTPLAVEGKALKAEPMRRGTSRSSAGSHKNRSTKISAQSVKKNRSRVQTILSQTSSQMSKLDMSGNASAYAQGRIMDVQQYLAQDLDTLSVSPQDGSDDVWSARAIRLFPPQTAQHSNSPALQRPVTQCHRLNRKLDASQYVTTEDLHGNMIPAIGDDGFALPHSAFGSRRMSGEGESARDHYLYKNAFPHADGLFHCPWEGQASCNHKAEKLKCNYDKFVDSHLKPYRCKVEGCQNARFSSTACLLRHEREAHAMHGHGEKPYLCTYEGCERSIAGHGFPRQWNLRDHMRRVHNDNGTTAQPASPPPSGAATTSRGRKRKSDAAEKQSNQEKPSSRKSSKAAVESVAQAQKQPEPVAHPELDQWYEHQKSLQTFIQGCVQPDDAQTLQYIKDAQEHLNAMGKISHGLIQGSRRSWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HA10</accession>
    <name>Q2HA10_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_02944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229460.1">
        <property type="nucleotide sequence ID" value="XM_001229459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HA10"/>
    <dbReference type="GeneID" id="4389539"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02944"/>
    <dbReference type="HOGENOM" id="CLU_3351016_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HA10"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ91009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="37" mass="3956" checksum="9877E5B509A61F4D" modified="2006-03-21" version="1">MWPPGTTQSTYIHVHLEVAVSSVAGTLPLGRQHGVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HA31</accession>
    <name>Q2HA31_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="4 12">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">5-proFAR isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_02923</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="4 12"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229439.1">
        <property type="nucleotide sequence ID" value="XM_001229438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HA31"/>
    <dbReference type="FunCoup" id="Q2HA31">
        <property type="interactions" value="194"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HA31"/>
    <dbReference type="GeneID" id="4388409"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02923"/>
    <dbReference type="eggNOG" id="KOG3055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065050_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HA31"/>
    <dbReference type="OMA" id="IEWNKTH"/>
    <dbReference type="OrthoDB" id="446074at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04723">
        <property type="entry name" value="HisA_HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000110">
        <property type="entry name" value="1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011858">
        <property type="entry name" value="His6/HISN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02129">
        <property type="entry name" value="hisA_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090:SF2">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 12 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ90988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="275" mass="29895" checksum="5CB941C64B89717F" modified="2006-03-21" version="1">MTRFRPCIDLHAGEVKQIVGGTLDSKTSSLQTNFVSPHPPAHFAKLYRDNALTGAHVIMLGPGNRDAAREALAAWPGALQVGGGINDTNAKEWIDAGAEKVIITSFLFPNGTFSQARLDSVLAALDGDKSKLVIDLSCRRHGGEDRWFVAMDKWQTITDMEVNQESIRLLEPSCSEFLIHAADNEGLQRGVDEALVARLAEWCSIPVTYAGGGRHLADLERVQRLSGGRVDLTIGSALDCFGGRGVTLEECVAWNRRQEVEEREQGEGEVAGEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HA40</accession>
    <name>Q2HA40_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_02914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229430.1">
        <property type="nucleotide sequence ID" value="XM_001229429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HA40"/>
    <dbReference type="GeneID" id="4388685"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02914"/>
    <dbReference type="HOGENOM" id="CLU_2468855_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HA40"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208672" evidence="2">
        <location>
            <begin position="22"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ90979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="88" mass="8335" checksum="17CFF51986BD7F1E" modified="2006-03-21" version="1">MHYATILVAFGALASIPAATGAERSSLESQLADPTSSSASAVSSVESEAASATESATATGNVGAAGVRAGKGVGVGMVVGGVVVWVGL</sequence>
</entry>
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                <person name="Untereiner W.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF07716">
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    </dbReference>
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    </dbReference>
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            <end position="589"/>
        </location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="507"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="572"/>
        </location>
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            <begin position="604"/>
            <end position="797"/>
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    </feature>
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            <end position="202"/>
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    </feature>
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        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
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            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
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            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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            <begin position="548"/>
            <end position="572"/>
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            <end position="654"/>
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            <end position="705"/>
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            <end position="763"/>
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            <end position="797"/>
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        </source>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
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    <sequence length="797" mass="84979" checksum="FD6EB96A662B9867" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="4389613"/>
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    <dbReference type="HOGENOM" id="CLU_006524_10_0_1"/>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="prtT"/>
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    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF10">
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    </dbReference>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ90941.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAC7</accession>
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        <recommendedName>
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            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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    <dbReference type="OrthoDB" id="62853at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="487"/>
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            <end position="85"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ90892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="487" mass="52112" checksum="FE7ADF67122D8A0A" modified="2006-03-21" version="1">MSGKNGHATPPAEGATPAVETKDDATKKDAVDTEMKEAPAAESKAAVESRAEPAAAADSTKEAEKPAEASSEKPAEQTEDNKSDVEMADAAAPVEPAPEGADAGASAGADQADQAAADAADAASGDADKSKSRRKSIGGGAAKGKKLNKKASKPRMLNLDAEPGDHYFVKLKGFPQWPVIICDEDMLPASLLKSRPVTAKRADGTYREDYADGGKNVADRTFPVMYLHTNEFGWVPNTELIKLDPETVLDVKLDKMRKTLQAAHHLASENHPLSYYKEVLQNYQEELIEQEKAKAAKAATPKGKKSKALSEDDDDVDMEDAPDVDETPAKDKKAKKRKAEDSAETPRRSDSVKKPKIKLTTSATPKTANGATATPKSTKATDAKSSKSKSKKKDADDKDAEEAAAAKETEQLSAEDKHTRKSVLKAILKLETFLKRDEFKSQPRSQVLLDKWNKLLAVDGTPTAPAAEHLPLTHPKDKAAEAVEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAK4</accession>
    <name>Q2HAK4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_02750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin AB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229266.1">
        <property type="nucleotide sequence ID" value="XM_001229265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAK4"/>
    <dbReference type="FunCoup" id="Q2HAK4">
        <property type="interactions" value="431"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HAK4"/>
    <dbReference type="GeneID" id="4389013"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02750"/>
    <dbReference type="eggNOG" id="KOG0653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020695_10_2_1"/>
    <dbReference type="InParanoid" id="Q2HAK4"/>
    <dbReference type="OMA" id="FMAYRPS"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20568">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000005">
        <property type="entry name" value="G2/mitotic-specific cyclin B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="259"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="352"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="356"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ90815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="488" mass="55128" checksum="413C92522F4EC8D6" modified="2006-03-21" version="1">MPITRTRNPRSVTNENDENSNATARVTRAKAAATLNVDELAMPTKALQSKKTAANVNPTRRRAALGDVSNVTKVEAVESKKAVGRTGLVSKAAQPTGVQKKTTATRSALTTKEVNKKTEVKRSGPGSIVAQKRKVLSTSTTNTLVKEGTPEDSEPIRKKVHTLEDKKIKTDVRQEEPVRKDAAPSSPPVAASEPEPRVEIPEAALFLDREDLDDPLMVAEYANDIFEYLRDLECNSVPNPQYMSHQDDLEWKTRGILIDWLVEVHTRFHLLPETLFLAVNIVDRFLSEKVVQLDRLQLVGITAMFIASKYEEVLSPHIANFRHIADDGFTEAEILSAERFVLATLNYDLSYPNPMNFLRRISKADNYDIQSRTIGKYLMEISLLDHRLMAYRSSHIAAAAMYLSRLILDRGEWDDTLEYYAGYSEEEIQPVVMLMVDYMARPVIHEAFFKKYAHKKFLKASILTRQWSKKNAHLYGIDDIHLTLSEVS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAX7</accession>
    <name>ARGJ_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arginine biosynthesis bifunctional protein ArgJ, mitochondrial</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">Glutamate N-acetyltransferase</fullName>
                <shortName evidence="1">GAT</shortName>
                <ecNumber evidence="1">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">Ornithine acetyltransferase</fullName>
                <shortName evidence="1">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="1">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">N-acetylglutamate synthase</fullName>
                <shortName evidence="1">AGS</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="1">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="1">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name type="ORF">CHGG_02627</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">The alpha and beta chains are autoproteolytically processed from a single precursor protein within the mitochondrion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ArgJ family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="1"/>
    <dbReference type="EC" id="2.3.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229143.1">
        <property type="nucleotide sequence ID" value="XM_001229142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAX7"/>
    <dbReference type="SMR" id="Q2HAX7"/>
    <dbReference type="FunCoup" id="Q2HAX7">
        <property type="interactions" value="268"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HAX7"/>
    <dbReference type="MEROPS" id="T05.001"/>
    <dbReference type="GeneID" id="4389645"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02627"/>
    <dbReference type="eggNOG" id="KOG2786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027172_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HAX7"/>
    <dbReference type="OMA" id="WGRIVMA"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.70.12:FF:000001">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.340:FF:000002">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2330.10:FF:000001">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2330.10">
        <property type="entry name" value="arginine biosynthesis bifunctional protein suprefamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="entry name" value="ArgJ beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.70.12">
        <property type="entry name" value="L-amino peptidase D-ALA esterase/amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003802">
        <property type="entry name" value="PRK05388.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100:SF0">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="DmpA/ArgJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000398040" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="1">
        <location>
            <begin position="34"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000398041" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="1">
        <location>
            <begin position="241"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="1">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="1">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="1">
        <location>
            <begin position="240"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03124"/>
        </source>
    </evidence>
    <sequence length="471" mass="49973" checksum="B5DA6B98CE8A0015" modified="2006-03-21" version="1" precursor="true">MAMAGCNGFFLHQLRQPRLQLARQLGRTPSRAYSAPSNGSIPAAKKKYVPTKGTYPLGFRTSGTIVGVKPSNTTKPDLALLTSDAPCVAAAVFTKNKFQAAPVTFSRNLLERRKNQGIQSVIINSGCANAVTGKGGLEDATKMAQEADKCTGQNESTIVMSTGVIGQRLPIDKILNKVPSAHGALGGSHDHWLAAAKAICTTDTFPKLMSRTFALPSSPGVEYRIAGMTKGAGMIHPNMATLLGVIATDAPITSAALPSALKHAVDRSFNSITIDGDTSTNDTVALFANGAAGGKEVAEGTPDYDAFRAVLTDFAAELAQLVVRDGEGATKFVTVRVTESASEEAARRIASTIARSPLVKTALYGKDANWGRILCATGYSLISEPGQPINDVPEIAPEKTNVSFIPTDGTAELKLLVNGEPEKVDEARAAEILELEDLEILVRLGQGDKQATYWTCDYSHEYITINGDYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBJ7</accession>
    <name>Q2HBJ7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_02407</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228923.1">
        <property type="nucleotide sequence ID" value="XM_001228922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBJ7"/>
    <dbReference type="STRING" id="306901.Q2HBJ7"/>
    <dbReference type="GeneID" id="4389683"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02407"/>
    <dbReference type="eggNOG" id="KOG2304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HBJ7"/>
    <dbReference type="OMA" id="MAHPMGP"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF5">
        <property type="entry name" value="3-HYDROXYBUTYRYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="7">
        <location>
            <begin position="31"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="220"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="35"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="4">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ90472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="33600" checksum="019DF77FA54F0B03" modified="2006-03-21" version="1">MMAARQALRLSSRVRYFSSTAARPAAEVKRLGVIGAGQMGLGIALVAAQKAQVPVTLVDSSQASLDKGLAFAEKLLVKDVAKQRLTQEQADAARALLQPTTSIDDLSSADFVIEAVPEIPQLKFDIFSKLAQICPKHAILATNTSSISITRIAAATTGGNPTDTSNSSRVVSTHFMNPVPVQKGVEIISGLQTSAETLETAVAFCKRLGKVTSVSADSPGFLANRILMPYINEAVICLETGVGDRDSIDAIMKNGTNVPMGPLQLADFIGLDTCLAIMKVLHTETGDSKYRPSVLLRNMVDAGWLGKKSGKGFYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCD6</accession>
    <name>Q2HCD6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_02118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221339.1">
        <property type="nucleotide sequence ID" value="XM_001221338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCD6"/>
    <dbReference type="GeneID" id="4386359"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02118"/>
    <dbReference type="HOGENOM" id="CLU_776124_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCD6"/>
    <dbReference type="OrthoDB" id="4580573at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209401" evidence="2">
        <location>
            <begin position="20"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="357" mass="40278" checksum="24234D0D932F558B" modified="2006-03-21" version="1">MHIARVAVTLALAASTTNALPWIKSRGDPNAPGVNADNLDTTREVHGKGSSPDSMHPSMKMVASSNQPVQQEMMEDSSLSVSQQMFLDQEHDIKPDLAAAAAPYRQSKEMIQLTRATEPQLSGEGSVMSSCSSEMPAVQQKAMDIQDHGAATDVSRSENKINNFAVKARELFRVFGQAWDQRAKLEHGEQQQGTVKYTANANQDKSQVSLPTDRENPVNVQKQQAADSMWQAEKVRQVRNHESYNQRPENESADIDGQQHSAMPQNQNYARSHMDGSNVQAHEMEQMNGWQSLDREQHQEHMNMRETKCRHQQQQMQEQEQMQEQMQVRPEMAEDLQSAMNDIHRLMPSQSHRGIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCL6</accession>
    <name>Q2HCL6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7708 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_02038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221259.1">
        <property type="nucleotide sequence ID" value="XM_001221258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCL6"/>
    <dbReference type="STRING" id="306901.Q2HCL6"/>
    <dbReference type="GeneID" id="4387663"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02038"/>
    <dbReference type="eggNOG" id="ENOG502TJKA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018311_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCL6"/>
    <dbReference type="OMA" id="MASHAID"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7708" evidence="2">
        <location>
            <begin position="260"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="927" mass="102458" checksum="63BEA7F2CB0445F7" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCR3</accession>
    <name>Q2HCR3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221212.1">
        <property type="nucleotide sequence ID" value="XM_001221211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCR3"/>
    <dbReference type="STRING" id="306901.Q2HCR3"/>
    <dbReference type="GeneID" id="4386611"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01991"/>
    <dbReference type="eggNOG" id="ENOG502S8TM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002639_3_0_1"/>
    <dbReference type="InParanoid" id="Q2HCR3"/>
    <dbReference type="OMA" id="CLENCAT"/>
    <dbReference type="OrthoDB" id="4583699at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF11">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="159"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="450" mass="51423" checksum="EFCE7CB277B24291" modified="2006-03-21" version="1">MICDRCRDALQGVASIDESWAVGLKHRPEEDVSDERVRMSYGIKHHPTYESFREALAQRCSVCIALWEGLEPEEQGIFENTTRTDPSQHPVTLTRHTRSPETLDLAKRWVTSCVRHHGKCRAGSGDGTWYPTRLLDLSRVTNTAEPWAGQRLVEGVSLGSLPQLMQDVIFVSLELGIHYIWIDLLCIFQDEDDITDWQQESALMNKVYSNTFCNISAGDANGCLESLFNTRDADSFLPQVIELQVGRGDHKTQLFRVYDLDYWRRSISGALVNKRGWVLQERFLSARVLQFDKRQVLWECLENCATETCPEQIPRHLLGRDHRIFKNMVNPTIQVEVRHLWTCLVQEYTACDLTVPSDKLVAVSGIAKHIAALLQDSHFYGKTSRPAEYRAPSWSWASIDGPVAPGPQLLKHPLIKVEEVHLEYLTDDVYGAVTWGWIRLRGALRQRQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HD41</accession>
    <name>Q2HD41_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycoside hydrolase family 5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_01863</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221084.1">
        <property type="nucleotide sequence ID" value="XM_001221083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HD41"/>
    <dbReference type="STRING" id="306901.Q2HD41"/>
    <dbReference type="GeneID" id="4386392"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01863"/>
    <dbReference type="eggNOG" id="ENOG502S659">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020735_3_0_1"/>
    <dbReference type="InParanoid" id="Q2HD41"/>
    <dbReference type="OrthoDB" id="442731at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263:SF0">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="101"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ93628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="354" mass="38831" checksum="F4478069C2D8E9B9" modified="2006-03-21" version="1">MFPVLLLLGAALGALLVYLYRAESRLRLPWVPDAEARLFAQRPLPPPLDDTFLSSPNYTLPLRTRGRDVIDARGRRFKLASVNWYGASDELFVPGGLDVKHRDEIARMVRVLGFNSVRLPYADELVLRNPVVAPHLLAANPDLVGRRAMDVLEAVVDALTRAGIAVIVNNHITSATWCCGADPCDAGWANDHLPSMMCRVRQTEEEWIEHWEEVMRRFVGNPLGGGRRPSQRGARRVVTMKCEPLATAVERAGIRLLKMTPDWLIIVRRNRVAERPHRRGGAGPSCSTCRTASSTRPTSICGAAGAASAAVTPSAHYPSFVQSMQQEIGPTCSRGDIAPVWVGKFGAPPKPRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDE1</accession>
    <name>Q2HDE1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_01763</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220984.1">
        <property type="nucleotide sequence ID" value="XM_001220983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDE1"/>
    <dbReference type="GeneID" id="4386746"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01763"/>
    <dbReference type="eggNOG" id="ENOG502SRJN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173454_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HDE1"/>
    <dbReference type="OMA" id="TLYCYFC"/>
    <dbReference type="OrthoDB" id="5290969at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF3">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="6">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ93528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="110" mass="11793" checksum="5366A74FA2CC9980" modified="2006-03-21" version="1">MDASCQCGAVSFKTPTEKPLALYICHCHDCQRQASSAFGASAIFPRFQLPDAELLSCYKRATSTGQTMFWTKSAMVPIPEGSETYSEESDLAEYSDGSPGSLDKPIGLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDJ4</accession>
    <name>Q2HDJ4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Endoplasmic oxidoreductin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CHGG_01710</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220931.1">
        <property type="nucleotide sequence ID" value="XM_001220930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDJ4"/>
    <dbReference type="FunCoup" id="Q2HDJ4">
        <property type="interactions" value="666"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HDJ4"/>
    <dbReference type="GeneID" id="4386988"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01710"/>
    <dbReference type="eggNOG" id="KOG2608">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023061_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HDJ4"/>
    <dbReference type="OMA" id="CYKDRLH"/>
    <dbReference type="OrthoDB" id="269384at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017205">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 17" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209410" description="Endoplasmic oxidoreductin-1" evidence="20">
        <location>
            <begin position="23"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="497"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="108"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="411"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EAQ93475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="23">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="61215" checksum="AA8F58CA1B1A6283" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDW4</accession>
    <name>Q2HDW4_CHAGB</name>
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        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_01590</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220811.1">
        <property type="nucleotide sequence ID" value="XM_001220810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDW4"/>
    <dbReference type="FunCoup" id="Q2HDW4">
        <property type="interactions" value="857"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HDW4"/>
    <dbReference type="GeneID" id="4386290"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01590"/>
    <dbReference type="eggNOG" id="KOG2575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008110_2_1_1"/>
    <dbReference type="InParanoid" id="Q2HDW4"/>
    <dbReference type="OMA" id="FQVPPMH"/>
    <dbReference type="OrthoDB" id="5589195at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042281">
        <property type="term" value="F:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF1">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="514"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="549"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ93355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="594" mass="66645" checksum="8D0AB28CAE745644" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HE14</accession>
    <name>Q2HE14_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_01540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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                <person name="Birren B.W."/>
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            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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</entry>
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                <person name="Untereiner W.A."/>
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            </authorList>
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        </source>
    </reference>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="1">Belongs to the sel-1 family.</text>
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        <property type="project" value="TreeGrafter"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="OMA" id="WKHQRRT"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:monooxygenase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450 monooxygenase (Fum15)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450I"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
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    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ92536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="59418" checksum="9CF561C3A47DFCE8" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGE0</accession>
    <name>Q2HGE0_CHAGB</name>
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        <recommendedName>
            <fullName evidence="1">SCP2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219935.1">
        <property type="nucleotide sequence ID" value="XM_001219934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGE0"/>
    <dbReference type="STRING" id="306901.Q2HGE0"/>
    <dbReference type="GeneID" id="4386736"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00714"/>
    <dbReference type="eggNOG" id="KOG4170">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105945_0_2_1"/>
    <dbReference type="InParanoid" id="Q2HGE0"/>
    <dbReference type="OMA" id="WTIDMKK"/>
    <dbReference type="OrthoDB" id="10265837at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1050.10:FF:000001">
        <property type="entry name" value="Putative Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094:SF25">
        <property type="entry name" value="SCP2 STEROL-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094">
        <property type="entry name" value="STEROL CARRIER PROTEIN 2 SCP-2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="19"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="126" mass="13415" checksum="B13943D242CBEB9E" modified="2006-03-21" version="1">MSLKNDKFPSSAAFDEINNALNASEADRKDAMKQGNAVFAFTLKNAAGETESWHIDLKNKGAVGTGVGEKPTVTLSLSESDFGSLVAGKANAQRLFMSGKLKIKGDVMKATKLDPILKKAQTKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGT5</accession>
    <name>Q2HGT5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TECPR1-like DysF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_00569</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219790.1">
        <property type="nucleotide sequence ID" value="XM_001219789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGT5"/>
    <dbReference type="FunCoup" id="Q2HGT5">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HGT5"/>
    <dbReference type="GeneID" id="4386972"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00569"/>
    <dbReference type="eggNOG" id="ENOG502QQTF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024267_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HGT5"/>
    <dbReference type="OMA" id="QNCMDDF"/>
    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052816">
        <property type="entry name" value="Peroxisomal_Membrane_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="TECPR1-like DysF" evidence="7">
        <location>
            <begin position="102"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="TECPR1-like DysF" evidence="7">
        <location>
            <begin position="405"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="311"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="379"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="492"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ92334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="569" mass="63004" checksum="91131D9EF10E73AA" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGV2</accession>
    <name>Q2HGV2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_00552</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219773.1">
        <property type="nucleotide sequence ID" value="XM_001219772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGV2"/>
    <dbReference type="FunCoup" id="Q2HGV2">
        <property type="interactions" value="256"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HGV2"/>
    <dbReference type="GeneID" id="4387971"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00552"/>
    <dbReference type="eggNOG" id="KOG3771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025518_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HGV2"/>
    <dbReference type="OMA" id="CKIYGMI"/>
    <dbReference type="OrthoDB" id="2159336at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07599">
        <property type="entry name" value="BAR_Rvs167p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000048">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="3">
        <location>
            <begin position="17"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ92317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="431" mass="49526" checksum="57B36BBC7C234AC6" modified="2006-03-21" version="1">MSFKGLQKGLARAPQQFKVKFNIGEHTKDAVYIDSERRFDELETETKRLHDESRKYFDAINGMLAHQIAFSQAMTEIYKPISGRMSDPDSLVVHGNPEGIRACEEYEAVVKDLQETLAPELEMIESRVIRPADELLDVIKVIRKTAIKREHKKLDYDRRRATLKKLQEKKDKTAKDEKATWKAENELEESTQEFNYFNDLLKEELPKLFALEREFIQPLFQSFYYMQLNIFYTLHERMQQVDIGYFDLTLDVEEAFLKKRGDVQERAEALSIVKFKTSGQKRPPKYGPKPRLEGPKTAGLLTAGPSPALPHRHPRTRTRPLRRHRRRRPPRTHDLRPSRARKIPRPLRAPPLLATPPKRNLGAPAAAVLAGPRVPRAGRRCRRQVQAAAAQAQAEPAVGDARRAQGRDGYGPVRLRGASRGGFEFPRGRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH71</accession>
    <name>Q2HH71_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219654.1">
        <property type="nucleotide sequence ID" value="XM_001219653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH71"/>
    <dbReference type="STRING" id="306901.Q2HH71"/>
    <dbReference type="GeneID" id="4387681"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00433"/>
    <dbReference type="eggNOG" id="KOG2406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006241_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HH71"/>
    <dbReference type="OMA" id="PHANDAP"/>
    <dbReference type="OrthoDB" id="27237at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07093">
        <property type="entry name" value="SGT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="457" mass="49865" checksum="2E405FB1CDA73D56" modified="2006-03-21" version="1">MDTAAEPRPGDEDFDGFRMSVSEDYAEYMLFVIGDKADNNLPSLEAVRKAADRKLDELAKDYIWQREPFKLEAKTQKGLGLSYLHGITHYGDNVEDEWLIVYLLRELSKTYPQLWIRVSDSDGEFLLIEAAKVTPKWLSPENDGNRVWIHDGKLLIIPLADPTTTTSKPLSLPEAIKTIKTSPPSTLIHSPLVEAESFYRLEKYPAQITTALHHALATIPRKLAHILHLRPKAVAPATEAFYLRDPRALKPLLFPTPSPSPAATTQQQQQGANNGLTFPPTDLVTISVRFSKVLYAQLKSQHFAPPPAWTPAFRAVEAGTGAGAGAADASGPEAAKAKALARLELGMKLTIGFELLARTADQSASRVVREVALLLEDLVEDGGDSALPGDGEIAGWEGVGREDDHGWMDIDFGDFERELEGKKTAGGGGFGDAAAQADLQKIVSRFEAFLNDESGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHM9</accession>
    <name>Q2HHM9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219496.1">
        <property type="nucleotide sequence ID" value="XM_001219495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHM9"/>
    <dbReference type="GeneID" id="4387333"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00275"/>
    <dbReference type="HOGENOM" id="CLU_102605_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHM9"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="236" mass="25012" checksum="26A777A0990DB723" modified="2006-03-21" version="1">MDRHVGVDFRDSWIRGTDIAVVVVHNCVAEPIGKAETDDGSLQHSLSSPWIPSNSSTGNRASVFRMPPLPTPPHDYEKPHNVAAVDGQRAHGALAGPSVSQPTGTTPSNFQGITRTTSKRMSSPPPTRSGLATGSVHLPQSRIQVPIIPTSDTGRVHSRSVVQQQTRQCTTPGATVNAPTTEVTPAAKTSPTGFSAGDSTTTTAQTTPVTRASNRNRRKSQRALEADSNTQEAHTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHV1</accession>
    <name>Q2HHV1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219424.1">
        <property type="nucleotide sequence ID" value="XM_001219423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHV1"/>
    <dbReference type="GeneID" id="4387736"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00203"/>
    <dbReference type="HOGENOM" id="CLU_963121_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHV1"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="289" mass="31319" checksum="813D0CD506D5ECD7" modified="2006-03-21" version="1">MADLNRLDCSGLIGFAAVRIHPARDFQGCWSTRKERGRGICVCPREEGGRSLAAKTQSCNLATLRSMGKVSRLSPTRRYTRTLAIARGQLGARIRSHVQNIALLRVSADDARADRKMQGLEQENEDVVDRDLQDSPFRGMGLPSREEIDAVLKVQKKEDSSVTAKIQGRQTNPSFCACRRATRGAHGCPFTDAKDLQKGSARADRCGSSSDVMQHTSMWPWGFTRHWTLNKFPGRNGTALTDGPSCGVPRRARHAAAGRGGSAAFSNTSAARAAPASLASYTPSRTCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHX6</accession>
    <name>Q2HHX6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tricarboxylate transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_00178</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219399.1">
        <property type="nucleotide sequence ID" value="XM_001219398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHX6"/>
    <dbReference type="FunCoup" id="Q2HHX6">
        <property type="interactions" value="599"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HHX6"/>
    <dbReference type="GeneID" id="4387792"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00178"/>
    <dbReference type="eggNOG" id="KOG0756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_5_1_1"/>
    <dbReference type="InParanoid" id="Q2HHX6"/>
    <dbReference type="OMA" id="AWYAGCT"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000092">
        <property type="entry name" value="Mitochondrial tricarboxylate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000064">
        <property type="entry name" value="Mitochondrial tricarboxylate transporter (Ctp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="17"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="107"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="204"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ91943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="32463" checksum="24296D3F058DDC0D" modified="2006-03-21" version="1">MPSAPAKEDAHPAVKGPSALRSILAGATAGAVEIAITYPAEFAKTRTQLNRRLAAGQKLPWPPFGKQWYAGCTTLIIGNSAKAGIRFVAFDQYKKLLVDADGKMSGPRTVLAGFGAGVTESLLAVTPTESIKTTLIDDRKSANPRMRGFLHAVPIIARERGIRGFFQGFVPTTARQAANSATRFGSYTALKQLAEGYTAPGEKLGAAATFAMGGVAGLITVYVTQPLDTIKTRMQSIEARALYGNSFRCAALIFKQEGVLTFWSGALPRLARLIMSGGIVFTMYEKSMEMFDRLDPERRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GLZ1</accession>
    <name>Q2GLZ1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_11065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408038">
        <property type="protein sequence ID" value="EAQ82889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230241.1">
        <property type="nucleotide sequence ID" value="XM_001230240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GLZ1"/>
    <dbReference type="STRING" id="306901.Q2GLZ1"/>
    <dbReference type="GeneID" id="4397372"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_11065"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_4_1_1"/>
    <dbReference type="InParanoid" id="Q2GLZ1"/>
    <dbReference type="OMA" id="FSFEGFW"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF80">
        <property type="entry name" value="GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208364" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ82889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="608" mass="65247" checksum="FEDA8EC0C14E1056" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMB9</accession>
    <name>Q2GMB9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226152.1">
        <property type="nucleotide sequence ID" value="XM_001226151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMB9"/>
    <dbReference type="STRING" id="306901.Q2GMB9"/>
    <dbReference type="GeneID" id="4397346"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10885"/>
    <dbReference type="eggNOG" id="ENOG502SPRM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100665_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GMB9"/>
    <dbReference type="OMA" id="CEITHGR"/>
    <dbReference type="OrthoDB" id="2322999at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ83067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="245" mass="27453" checksum="11F128499D2141B5" modified="2006-03-21" version="1">MASDLCTDCVPCRASGKTDSVRAHDRVASFYRPDAYNTLPSLLNASHQLNELDGISTVSGPIRQLFLDHGVQERFGVILLHKHLDMEPTERLVECGCTSSPWDVGDATSPVVNKYEGTIVPRSFRLMDGSFVPYEFGYLHEGQHPASEEDSDAHFLQEFGRFLGEHQLDRVIGLRDLDQHDPKLNVEVTEGRANIMMPRGSVPESELIPAVWTFGLGEDDSCKCRGYCYYRGSDHTGQYSHTCQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMD1</accession>
    <name>Q2GMD1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 1-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_10873</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226140.1">
        <property type="nucleotide sequence ID" value="XM_001226139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMD1"/>
    <dbReference type="FunCoup" id="Q2GMD1">
        <property type="interactions" value="701"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GMD1"/>
    <dbReference type="GeneID" id="4397098"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10873"/>
    <dbReference type="eggNOG" id="KOG1668">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050172_0_2_1"/>
    <dbReference type="InParanoid" id="Q2GMD1"/>
    <dbReference type="OMA" id="YRWYKHI"/>
    <dbReference type="OrthoDB" id="331763at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10308">
        <property type="entry name" value="GST_C_eEF1b_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000001">
        <property type="entry name" value="Elongation factor 1-beta 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.130:FF:000001">
        <property type="entry name" value="Putative Elongation factor 1-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018940">
        <property type="entry name" value="EF-1_beta_acid_region_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001326">
        <property type="entry name" value="Transl_elong_EF1B_B/D_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF21">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10587">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01182">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00824">
        <property type="entry name" value="EF1BD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00825">
        <property type="entry name" value="EF1BD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="7">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="6">
        <location>
            <begin position="143"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ83055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="229" mass="25144" checksum="4A15855EB324911E" modified="2006-03-21" version="1">MGFTDLLTDAGLAVLDNWLLTRSYVIGYSASQADAVTFKALSAAPDAAKYPNAARWYKHIASYEDEFPTLPGDASKPYTVYGPEVAAVTLNPAKAPAAEEEEDDDVDLFGSDEEEDAEAVRVREERLAEYRKKKEGKVKPAAKSIVTMDVKPWDDETDMVGLEAAVRSIEKDGLVWGASQLIAVGFGIKKLQINLVVEDEKVSTDELAEEITEFEDYVQSVDVVAMQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN99</accession>
    <name>Q2GN99_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228482.1">
        <property type="nucleotide sequence ID" value="XM_001228481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN99"/>
    <dbReference type="STRING" id="306901.Q2GN99"/>
    <dbReference type="GeneID" id="4396410"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10555"/>
    <dbReference type="eggNOG" id="ENOG502RUEM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002639_2_12_1"/>
    <dbReference type="InParanoid" id="Q2GN99"/>
    <dbReference type="OMA" id="HESHIVY"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="240"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="712" mass="77396" checksum="B1F261C8C1BBECAB" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNA0</accession>
    <name>Q2GNA0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_10554</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228481.1">
        <property type="nucleotide sequence ID" value="XM_001228480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNA0"/>
    <dbReference type="STRING" id="306901.Q2GNA0"/>
    <dbReference type="GeneID" id="4396409"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10554"/>
    <dbReference type="eggNOG" id="KOG0104">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_5_0_1"/>
    <dbReference type="InParanoid" id="Q2GNA0"/>
    <dbReference type="OMA" id="SRTPMIQ"/>
    <dbReference type="OrthoDB" id="10262720at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004207968" description="Actin-like ATPase domain-containing protein" evidence="5">
        <location>
            <begin position="31"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="525"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="724"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="832"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="543"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="835"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="849"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="860"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="888"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="913"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ84150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="929" mass="101062" checksum="BB105841939DACAF" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNG1</accession>
    <name>Q2GNG1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228420.1">
        <property type="nucleotide sequence ID" value="XM_001228419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNG1"/>
    <dbReference type="STRING" id="306901.Q2GNG1"/>
    <dbReference type="GeneID" id="4396925"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10493"/>
    <dbReference type="eggNOG" id="ENOG502TDBR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_769828_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNG1"/>
    <dbReference type="OMA" id="HLESWCE"/>
    <dbReference type="OrthoDB" id="5406275at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="423" mass="46722" checksum="7F08330C4E44FC8B" modified="2006-03-21" version="1">MGNGNLGVSGEQPDNQSGDREASDSPSGARLGPRHVYSLDVQRVAKLELENSSLLLKTFPGANWASLIEAAPAIVRIMGVLLKISRDEAAAGLKIASPGIRGEDGEVIGKLPHNSFHTELESSIHSGRSVLKEFQGTTTWVFKAADRCLVHGGNISIEMLQDDHDVVANLVPEIDEVWEFAEDCLKRIRRLSQHLESWCEKNSFLKDMAREAIEHAQELAMSDVESLCDQKVIAPQAELHQKPIGDTLYNFQKPLVDLNARASQLAQSFSVLVELFTRVEEDAKDVQQTVKQGAKLKNNDELELMAMSQAAKKRVITKAFHLQSHASAIRDITATFVEVSNKYIKPALSKLETFSFGTGVECKVENEEFMTWCDNATAEIRALAAETDANLRPNIQDRILSLQEYAIDVAFPRSEGEGDRKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GP53</accession>
    <name>Q2GP53_CHAGB</name>
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        <recommendedName>
            <fullName evidence="2">PSP proline-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228178.1">
        <property type="nucleotide sequence ID" value="XM_001228177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GP53"/>
    <dbReference type="STRING" id="306901.Q2GP53"/>
    <dbReference type="GeneID" id="4396482"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10251"/>
    <dbReference type="eggNOG" id="KOG2330">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014435_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GP53"/>
    <dbReference type="OMA" id="KGEPIGQ"/>
    <dbReference type="OrthoDB" id="10260794at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007180">
        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052584">
        <property type="entry name" value="U2_snRNP_Complex_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785">
        <property type="entry name" value="SPLICING FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04037">
        <property type="entry name" value="DUF382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="2">
        <location>
            <begin position="283"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="550"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="624" mass="69215" checksum="637D17322B36FF71" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GP72</accession>
    <name>Q2GP72_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228159.1">
        <property type="nucleotide sequence ID" value="XM_001228158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GP72"/>
    <dbReference type="GeneID" id="4396607"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10232"/>
    <dbReference type="eggNOG" id="ENOG502S36W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075131_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GP72"/>
    <dbReference type="OMA" id="YILPRMP"/>
    <dbReference type="OrthoDB" id="5366541at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.70">
        <property type="entry name" value="Get5 dimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049256">
        <property type="entry name" value="Get5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024737">
        <property type="entry name" value="Get5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17183">
        <property type="entry name" value="Get5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12754">
        <property type="entry name" value="Get5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="82"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="248" mass="25619" checksum="01629157E5F8588D" modified="2006-03-21" version="1">MATELLFAKTFLSHLDGRPAKISPDHIEDPRSYPSHSPYTLPRHPSQKPFSKPPPTTTTGTTTTTSENAPTTKRNPGAAPATSVTLRSARNPPFELVLPAVALTTSLAEIKEQLAAETGIPLDKIKLLAGKKPVGDSKVLKELVSSSEGAGAGGVELGVMVLGGGAVFFKGLGGKEGGKEERGVGGEGGGEVTAAAAAPVAQGLSGEGVLKTEVFWEDLKGFLQQRVRDEGVAGDALGVFRGAWEGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPB7</accession>
    <name>Q2GPB7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Asparaginase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228114.1">
        <property type="nucleotide sequence ID" value="XM_001228113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPB7"/>
    <dbReference type="STRING" id="306901.Q2GPB7"/>
    <dbReference type="MEROPS" id="T02.004"/>
    <dbReference type="GeneID" id="4396259"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10187"/>
    <dbReference type="eggNOG" id="KOG1592">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021603_5_2_1"/>
    <dbReference type="InParanoid" id="Q2GPB7"/>
    <dbReference type="OMA" id="MKHRGRI"/>
    <dbReference type="OrthoDB" id="77601at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04514">
        <property type="entry name" value="Taspase1_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.30:FF:000007">
        <property type="entry name" value="Similar to threonine aspartase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037464">
        <property type="entry name" value="Taspase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF8">
        <property type="entry name" value="THREONINE ASPARTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="2">
        <location>
            <begin position="391"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="573" mass="60363" checksum="8BDE5FA2834DC290" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPK7</accession>
    <name>Q2GPK7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_10097</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228024.1">
        <property type="nucleotide sequence ID" value="XM_001228023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPK7"/>
    <dbReference type="STRING" id="306901.Q2GPK7"/>
    <dbReference type="GeneID" id="4396654"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10097"/>
    <dbReference type="eggNOG" id="KOG0853">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011001_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPK7"/>
    <dbReference type="OMA" id="NAAAWMY"/>
    <dbReference type="OrthoDB" id="937291at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03792">
        <property type="entry name" value="GT4_trehalose_phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052078">
        <property type="entry name" value="Trehalose_Metab_GTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049438">
        <property type="entry name" value="TreT_GT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779:SF1">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21269">
        <property type="entry name" value="TreT_GT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trehalose synthase N-terminal" evidence="8">
        <location>
            <begin position="200"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="7">
        <location>
            <begin position="421"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ83693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="672" mass="74792" checksum="8049249E8470BB59" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQ41</accession>
    <name>Q2GQ41_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_09913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227840.1">
        <property type="nucleotide sequence ID" value="XM_001227839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQ41"/>
    <dbReference type="GeneID" id="4397020"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09913"/>
    <dbReference type="eggNOG" id="ENOG502SNVG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_712005_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQ41"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="386" mass="43784" checksum="7B3CFECB8F00E242" modified="2006-03-21" version="1">MSKNGNPRGREKFDPSTVAVVPLQIPIVHGDEQEAKRRRNRLAQRKHRQRQRVKSNAGTEPDKPTYSERESGTSTSSISFDFDQPEEPVSSSLDFLLADCTDMDHHMRQTTNDSLDVGRETDFLLASLGAPDMEQQEDAMGDHQNCLPHHDVHHNLAPMGFHHMPQPSSMPIPQPSEAKIAPSFPMPTPVSDTESHHHKEHPPERRGRDLESRIQHIIRAVQEAGFESIDDMATQYYTAQFEEDTASYWAQSLSRSHSLYTFLSSLHRSTSAWSERDIQRYRQQILAAAESLYASEIDTAKNAKDVARPPTPVSSVEALWRMMGDMELDQEAKEKKMAIREKLPETWSLLARLTQKADLRQPQGSQVVFAFLLLLVESNRNQASRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQE5</accession>
    <name>Q2GQE5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Transcription elongation factor SPT5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_09809</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPT5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227736.1">
        <property type="nucleotide sequence ID" value="XM_001227735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQE5"/>
    <dbReference type="FunCoup" id="Q2GQE5">
        <property type="interactions" value="1122"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GQE5"/>
    <dbReference type="GeneID" id="4397073"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09809"/>
    <dbReference type="eggNOG" id="KOG1999">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003537_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GQE5"/>
    <dbReference type="OMA" id="YPVGYMN"/>
    <dbReference type="OrthoDB" id="28901at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140463">
        <property type="term" value="F:chromatin-protein adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003711">
        <property type="term" value="F:transcription elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06081">
        <property type="entry name" value="KOW_Spt5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06082">
        <property type="entry name" value="KOW_Spt5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06083">
        <property type="entry name" value="KOW_Spt5_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06085">
        <property type="entry name" value="KOW_Spt5_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09888">
        <property type="entry name" value="NGN_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000018">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000029">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.940:FF:000005">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041973">
        <property type="entry name" value="KOW_Spt5_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041975">
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    </dbReference>
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        <property type="entry name" value="KOW_Spt5_5"/>
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        <property type="entry name" value="Rib_uL2_dom2"/>
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    </dbReference>
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        <property type="entry name" value="TF_Spt5_eukaryote"/>
    </dbReference>
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        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="NusG-like N-terminal" evidence="11">
        <location>
            <begin position="231"/>
            <end position="325"/>
        </location>
    </feature>
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        <location>
            <begin position="329"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="538"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="698"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="Spt5 C-terminal" evidence="13">
        <location>
            <begin position="784"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="769"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="919"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="769"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="924"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00020181"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024691"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025870"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01104"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ83405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="971" mass="104705" checksum="CA8C074E15245A49" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQJ6</accession>
    <name>Q2GQJ6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_09758</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001227684.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="4396383"/>
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    <dbReference type="eggNOG" id="KOG3822">
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    <dbReference type="OMA" id="GMGPHPT"/>
    <dbReference type="OrthoDB" id="1933379at2759"/>
    <dbReference type="UniPathway" id="UPA00929">
        <property type="reaction ID" value="UER00894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
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        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
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        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
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        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF60">
        <property type="entry name" value="ACETATE COA-TRANSFERASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="4">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ83354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="535" mass="56630" checksum="1DC05B817DC1C4E5" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GR14</accession>
    <name>Q2GR14_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227517.1">
        <property type="nucleotide sequence ID" value="XM_001227516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GR14"/>
    <dbReference type="GeneID" id="4396357"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09590"/>
    <dbReference type="HOGENOM" id="CLU_2941526_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GR14"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="60" mass="6624" checksum="81F819AD016246CB" modified="2006-03-21" version="1">MASRGTQVGNNLGKVHAVARASVAQALERITKERQSSSKHKKNDQCRRPTSGRRDKSHTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GR27</accession>
    <name>Q2GR27_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">6-phosphogluconolactonase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_09577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227504.1">
        <property type="nucleotide sequence ID" value="XM_001227503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GR27"/>
    <dbReference type="STRING" id="306901.Q2GR27"/>
    <dbReference type="GeneID" id="4395110"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09577"/>
    <dbReference type="eggNOG" id="ENOG502RIAE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038716_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GR27"/>
    <dbReference type="OMA" id="AWVGTYN"/>
    <dbReference type="OrthoDB" id="9972196at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF1">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="Nitrous oxide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208513" description="6-phosphogluconolactonase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ85563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="38204" checksum="23C1E48A6D57D838" modified="2006-03-21" version="1">MSRFVQLFAAMALAPGTLGATLIASHFAGGIYSLSLATSNSSGTLSITSQTTGCGTTPGWLQLYADSRKLYCFDESWFGSGNSAEYTVANDGRLTSTGQLKTTGNSVHGLLYGGSDGRGFVATAEQDVAHPHEVHLDPTGKFIIVPDLGADLIRIFKIDASSGKLTACSEGKADPGDGPRHIKFWKSADGLQKAYTVNELGNSVSAWDVAYPSDDAGCLSLEKTQTLSTFAPGKQGGPTTKAAELRVVGNFLYASNRADETFGSQKDSIATYTIDASTGEIAWLEAANSYSYYPRTFEFNKDGTLVAVGGQTSSNVAIIARDTETGKLGALVATLQVGQKGRAGEEDGLSAVVWVESPAGECKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRT4</accession>
    <name>Q2GRT4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227247.1">
        <property type="nucleotide sequence ID" value="XM_001227246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRT4"/>
    <dbReference type="GeneID" id="4395012"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09320"/>
    <dbReference type="eggNOG" id="ENOG502T2V8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_709799_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRT4"/>
    <dbReference type="OrthoDB" id="59699at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="21"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="162"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="389" mass="43215" checksum="2323E2D9C1E4DBBF" modified="2006-03-21" version="1">MPTHLNRPDPNVAAAAREIRKRLFVFCDGTWQDGVNKARPLTNVATLARCLEPVDRHGCLQIVYYDGGVGSVTSAPAQLVDGATGRGISAKIRNAYSFLSHNWNFREGEDEIVLVGFSRGAFAVQCLASLISDAGLLQKTAPLLFARSLHPLGKPEIPKGPLAFVGNEVPDRVQHAFQAVALDEERSKFQPVLWTSKPATASVSQCWFLGSHADVGGNGDAALGGLSLVWMVGKLHGELGVAFDDKEIAKHLKHRFLEWDITLVPTYIHFTARLTMAQKRHMCPPMRSWTTLWAEQESGLAKIQWHSGSGRQIVDEHPLKEHDKEYEILRKWCHGEYRFLDTDRGPFAAVEAPMTAEELRGMAEFFRDHLKFENNKLSEGSMYLGSTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRY2</accession>
    <name>Q2GRY2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_09272</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227199.1">
        <property type="nucleotide sequence ID" value="XM_001227198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRY2"/>
    <dbReference type="STRING" id="306901.Q2GRY2"/>
    <dbReference type="GeneID" id="4395420"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09272"/>
    <dbReference type="eggNOG" id="KOG1211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_0_2_1"/>
    <dbReference type="InParanoid" id="Q2GRY2"/>
    <dbReference type="OMA" id="WMIERPQ"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF67">
        <property type="entry name" value="AMIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="3">
        <location>
            <begin position="113"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ85258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="665" mass="73655" checksum="E2FE743AB6663713" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GS06</accession>
    <name>Q2GS06_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GPI inositol-deacylase winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_09248</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227175.1">
        <property type="nucleotide sequence ID" value="XM_001227174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GS06"/>
    <dbReference type="STRING" id="306901.Q2GS06"/>
    <dbReference type="GeneID" id="4395584"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09248"/>
    <dbReference type="eggNOG" id="KOG0192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_663930_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GS06"/>
    <dbReference type="OMA" id="SYKGHDK"/>
    <dbReference type="OrthoDB" id="4588974at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208390" description="GPI inositol-deacylase winged helix domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="3">
        <location>
            <begin position="125"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="352"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="385"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ85234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="414" mass="45825" checksum="1E2E6F0D5CEBCFBB" modified="2006-03-21" version="1">MADSGDIAAWAALAAALLVLVVTLTQATQQYVATTPNMRKCEKSVWGPMPGHPGRRKAVDADIRSYVTAALKQNASFVDKRLPQDLLERICTKVGDGADGILHEPQSHWNRSETLPRDLYETYHRMLQGIPANIAKDAVRLLQFLVHAKRPLTLREAVEVIATQTDEEPRGLDPKRRLFREADVLRYCPGLVSVIEAYSDCGKTREELQLAHFSVKEYLLKQDQFDIKRASTVITKTCLSYLTCIEGSSFDKIEQDFPLTEYAAKNWIDYATLAQTSEDVVRATAKFLEDQSTVQDGIRSSRVTASSRPAQDPLKHPEVVRLLLEKGANVDASGGFFANALQAAIVEGHSSRFGNTLHLASYMGYIEIVRLLLDRGADVNSSGGDFDNALHVASFRGHTEIVQLLLDKGANNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSB5</accession>
    <name>Q2GSB5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">COQ3</name>
        <name evidence="7" type="ORF">CHGG_09139</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227066.1">
        <property type="nucleotide sequence ID" value="XM_001227065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSB5"/>
    <dbReference type="FunCoup" id="Q2GSB5">
        <property type="interactions" value="286"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GSB5"/>
    <dbReference type="GeneID" id="4395822"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09139"/>
    <dbReference type="eggNOG" id="KOG1270">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042432_3_1_1"/>
    <dbReference type="InParanoid" id="Q2GSB5"/>
    <dbReference type="OMA" id="LASRWWD"/>
    <dbReference type="OrthoDB" id="3265906at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120537">
        <property type="term" value="F:3-demethylubiquinone 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ85125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="308" mass="33667" checksum="98EF41536D092E13" modified="2006-03-21" version="1">MRSSLRHTPRALRAAHPASRPAPWLQQFHPQQSRAQPPSRKLSTTPPAHHNPSSPTSSSVNETEISHFSALASSWWDPHGPSRPLHLMNPHRHDFIQACLASSPQPDPTPNPLRYLDVGCGGGIFAESAARLPTTASVTAIDPSPQILAVARAHAKRDPSLSRGGKLTYLSETIESLPLPAAPADRFDVVSVFEVVEHVDYPAAFLDRVGEFVRPGGWLVLSTIARTWTSWVTTNLVAEDILGVVPKGTHDWYKYINEEELRAYFAGKGGVWGVPRVMGVVFVPGFGWKEVRGSEKVGNYFVGVQNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSH4</accession>
    <name>Q2GSH4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_09080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227007.1">
        <property type="nucleotide sequence ID" value="XM_001227006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSH4"/>
    <dbReference type="STRING" id="306901.Q2GSH4"/>
    <dbReference type="GeneID" id="4395638"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09080"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022195_9_2_1"/>
    <dbReference type="InParanoid" id="Q2GSH4"/>
    <dbReference type="OMA" id="VMHKYLA"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ85066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="61878" checksum="1F6296EF88B6DE59" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSQ9</accession>
    <name>Q2GSQ9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Complex I-ESSS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase ESSS subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_08995</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Complex I is composed of 45 different subunits. Interacts with BCAP31.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB11 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226922.1">
        <property type="nucleotide sequence ID" value="XM_001226921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSQ9"/>
    <dbReference type="STRING" id="306901.Q2GSQ9"/>
    <dbReference type="GeneID" id="4395299"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08995"/>
    <dbReference type="eggNOG" id="ENOG502S7S9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138649_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSQ9"/>
    <dbReference type="OMA" id="WETIFYY"/>
    <dbReference type="OrthoDB" id="2147978at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019329">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ESSS_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637:SF1">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10183">
        <property type="entry name" value="ESSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ84981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="120" mass="13536" checksum="264B2E86617E73AA" modified="2006-03-21" version="1">MSALRPHARLAVRSTLSLATAPITAVVPARYRYFSASPRRAVGGGMQYDPPSGWLWGVRPGEKYQNEGWEGPFFYGFWGSMIVFAVAYAWKPDTSIQTWALEEARRRLEAEGILEDPEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GST9</accession>
    <name>Q2GST9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SURP motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226892.1">
        <property type="nucleotide sequence ID" value="XM_001226891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GST9"/>
    <dbReference type="STRING" id="306901.Q2GST9"/>
    <dbReference type="GeneID" id="4395554"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08965"/>
    <dbReference type="eggNOG" id="KOG0151">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007957_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GST9"/>
    <dbReference type="OMA" id="VWYRWKL"/>
    <dbReference type="OrthoDB" id="377209at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF0">
        <property type="entry name" value="U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SURP motif" evidence="2">
        <location>
            <begin position="344"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="741" mass="80939" checksum="2284720B989A2409" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSX9</accession>
    <name>Q2GSX9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_08925</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226852.1">
        <property type="nucleotide sequence ID" value="XM_001226851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSX9"/>
    <dbReference type="FunCoup" id="Q2GSX9">
        <property type="interactions" value="367"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GSX9"/>
    <dbReference type="GeneID" id="4395168"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08925"/>
    <dbReference type="eggNOG" id="KOG0942">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002173_2_4_1"/>
    <dbReference type="InParanoid" id="Q2GSX9"/>
    <dbReference type="OMA" id="HWLMTNR"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000002">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="660"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="515"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="520"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ84911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1033" mass="116500" checksum="EE77F40B194BB8CD" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTU1</accession>
    <name>Q2GTU1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_08613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226540.1">
        <property type="nucleotide sequence ID" value="XM_001226539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTU1"/>
    <dbReference type="GeneID" id="4395797"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08613"/>
    <dbReference type="eggNOG" id="ENOG502SYM4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021744_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTU1"/>
    <dbReference type="OrthoDB" id="4568339at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="486" mass="55905" checksum="F4C9DB5222EBCBD1" modified="2006-03-21" version="1">MTATVELRKTSAPPLLRLPPAIRHQIYRLLGLVSWNGYPYNFELNGPGPQVFWNTWSWEQHSTSDFHGLLLSCRHLHAETATLLYSANRFVLRYANPGSLQPLFALSRTALTSLAELKVVLNQTSCHHPVQKYDYEDCCLYKSGWSLTAVISTCEQRYHSHHHQLPLLGPVPEGDSDLSDTVQALLSEWHAAANHLSSYLTPKRLELSLVCDIDPRHEKAVELAKSALKPLSLLPLLRSCHIRLCKTTDSRLRQLAQDAALQSTVHDFTILTPWSVPEIPFSYMYNSTSETAKMEYPYERLAASQFLRQVIPGHCIAQLRFLELVFPPYRPYTWPETDHPVMRDWRETVAWLRDMINGPALTLRLIAIRYTSDSDFEGPITVAEGDKVHRAYMDLLEPLKALAEGANGISKFYASLRHPWELTFENENRRTGMEDFFEDSWLQAEERALKQRAERHVMGDRYESLYANGRKEPPQSLWHHVLKRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU19</accession>
    <name>Q2GU19_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_08535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226462.1">
        <property type="nucleotide sequence ID" value="XM_001226461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GU19"/>
    <dbReference type="STRING" id="306901.Q2GU19"/>
    <dbReference type="GeneID" id="4395437"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08535"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017442_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GU19"/>
    <dbReference type="OMA" id="WAGHRTE"/>
    <dbReference type="OrthoDB" id="5244787at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="398"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="809"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="823"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ84521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="838" mass="94414" checksum="44A01BCF7900E013" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUN4</accession>
    <name>Q2GUN4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cobalamin-independent methionine synthase MetE C-terminal/archaeal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ87067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225976.1">
        <property type="nucleotide sequence ID" value="XM_001225975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUN4"/>
    <dbReference type="STRING" id="306901.Q2GUN4"/>
    <dbReference type="GeneID" id="4393915"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08320"/>
    <dbReference type="eggNOG" id="ENOG502SKSR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058877_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUN4"/>
    <dbReference type="OMA" id="YNRTRFW"/>
    <dbReference type="OrthoDB" id="7772923at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844:SF2">
        <property type="entry name" value="SYNTHASE, VITAMIN-B12 INDEPENDENT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="1">
        <location>
            <begin position="179"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="401" mass="45443" checksum="6C688CB7F77E42D7" modified="2006-03-21" version="1">MPPFRAEHMGSLLRPQALLDVREAIREKGLSPEAAGLPAVEEKAVGHVVKLQQDLGLKAVTSGEYNRTRFWGLMWDEFEGTVRLEDADAALFRLYHPDVVSLVEVARKVMPGDSVIAGSKLRHNPEKSQSNLHELRLVQKFVPKSEWGSIKLTMITPAWFHMRYKQGKAYSKEAYANDAEYFKDVASVYQAELDQLYKAGLRNVQFDDPGLAYFCSDKFRQGWAEDPDNIGSVDDLLEAYINLYNDCISKLPADFHTGVHLCRGNFIGGRFFSEGGYDVIAQKLFTKLKVNTFYLEYDTERAGGFEPLKFLPKDRNVVIGAISTKLRELEDKEEVKRRIYQAADFVAEGNGQTREEALKRICVSPQCGFSTHESGYPLTEEDEKNKLALIRQIADEIWGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUZ3</accession>
    <name>Q2GUZ3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225867.1">
        <property type="nucleotide sequence ID" value="XM_001225866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUZ3"/>
    <dbReference type="STRING" id="306901.Q2GUZ3"/>
    <dbReference type="GeneID" id="4394565"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08211"/>
    <dbReference type="eggNOG" id="ENOG502QRXF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010063_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GUZ3"/>
    <dbReference type="OMA" id="AFIKGHK"/>
    <dbReference type="OrthoDB" id="2506204at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208497" evidence="2">
        <location>
            <begin position="30"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ86958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="767" mass="83644" checksum="D3E5C4DC507612AA" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV38</accession>
    <name>Q2GV38_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_08166</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225822.1">
        <property type="nucleotide sequence ID" value="XM_001225821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV38"/>
    <dbReference type="STRING" id="306901.Q2GV38"/>
    <dbReference type="GeneID" id="4393295"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08166"/>
    <dbReference type="eggNOG" id="KOG2940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046586_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GV38"/>
    <dbReference type="OMA" id="YEVVYGH"/>
    <dbReference type="OrthoDB" id="16816at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050602">
        <property type="entry name" value="Malonyl-ACP_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090:SF1">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="121"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ86913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="352" mass="38600" checksum="DD9953843279F6CD" modified="2006-03-21" version="1">MRLNLPRACRPQYIRLQTTTPSSTRRTYAFQAPGGAVFKVFNSRSKWQQKERAAANPELSRQADYLKDEVAMRVCERLLDIKRHFPRVLDLGANSCNIARALTRENPDPDPATPTSPPLSNKIISLIAADSSATLLHRDASLPFNDQLDLTRQVLADDETLPFAPASFDMVLSSLSLHWINDLPGVLAQINNVLKPDSPFIGAMLGGDTLFELRTSLQLAEQERRGGISPHVSPLADVRDVGGLLGRAGFQMLTVDVEDVVVDYPDTFALMQDLQAMGEGNAVLGREMGAIGRDVLLANEGIYRALHGNEDGSLPATFRIIHMIGWKEGGNQPKPLKRGSGEVSLKDILEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVW1</accession>
    <name>Q2GVW1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_07893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225549.1">
        <property type="nucleotide sequence ID" value="XM_001225548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVW1"/>
    <dbReference type="STRING" id="306901.Q2GVW1"/>
    <dbReference type="GeneID" id="4393732"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07893"/>
    <dbReference type="eggNOG" id="ENOG502RKND">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1805960_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GVW1"/>
    <dbReference type="OMA" id="CEFGSVI"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ86640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="143" mass="15847" checksum="17F66D0336C0DDA7" modified="2006-03-21" version="1">MALAYRGEGRILPSLNHSHIIRSFHSQGWGSPRVEIVMSLMEGTVASLNETYPPERRPQLANSVLRQMLPALAYLDELGYVHRDVKPDNIFYNTTGPHTHHFQLGDFGLCEFGSVIAAAGGDAVGPKSYKAPELHRDHPRKGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GW24</accession>
    <name>Q2GW24_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein mL38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_07830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225486.1">
        <property type="nucleotide sequence ID" value="XM_001225485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GW24"/>
    <dbReference type="FunCoup" id="Q2GW24">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GW24"/>
    <dbReference type="GeneID" id="4393186"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07830"/>
    <dbReference type="eggNOG" id="KOG3346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035836_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GW24"/>
    <dbReference type="OMA" id="FRTQWDE"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.280.10:FF:000004">
        <property type="entry name" value="Mitochondrial large ribosomal subunit YmL35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ86577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="472" mass="53468" checksum="33897D7D16DE1AB6" modified="2006-03-21" version="1">MSRPQLVARPIVRSLRQATGSTAATCPSRPLALRPFSSTPSRKDETTTTTGTPTEPSPDAQKLAAEAALLGQKKPPPYPSMIKQGTEDQLAQLMSPHLGSRRRRAALATTGTIPFEQLPYQCFQEARKILAQDREEKVAKIVAETAKIKRLEAADASTFRGGEAYKQKRLESLRAHVEKLKILADINDPLVKRRFEDGQGDMNKPIYRYLAHRKWSGMERNIILQRIEQFHIVPDLLPKFQPTMDVKMTFRGYKTPPGATLNSRITEIPPTLRMQVFEKGERLFSVVVLDADVPDAETDSFKKRLHFLATNIPWSPTRDSLFLNRLGTAAAASQPELGTLAVPWLPPFAQKGAPYHRLTVFILEHKDNLPLDAAKLKEMYDGQGRDGFSLKSFRDKFSVTPVGFTMFRSEWDENTADVMARHGIPGADVEFKRQRVMSLKPPRKARGWEARRQGPKYRHLWKYTKRIKGVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWT6</accession>
    <name>Q2GWT6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225224.1">
        <property type="nucleotide sequence ID" value="XM_001225223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWT6"/>
    <dbReference type="GeneID" id="4393331"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07568"/>
    <dbReference type="HOGENOM" id="CLU_1360273_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWT6"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="201" mass="21465" checksum="DBA44F71E08ED622" modified="2006-03-21" version="1">MSSLTYSADLELPPSTPQLSRFNPHDVAFGITPLARHPEAPRPRTPLGIGNGAPVPWNHWLAKHNLNQSGPNDSGSTQPNTPQIGKQTGRAALRTIIWVFKLIMFNESTKRGLSQSPSKGGYGHALDNSAQKARLFRNALRRKLVRCRIAPAEGGATQPSGAAKGDRFGGLCAPFPAIAGRGSTQETSEENDPAGRGSQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX72</accession>
    <name>Q2GX72_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_07432</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225088.1">
        <property type="nucleotide sequence ID" value="XM_001225087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX72"/>
    <dbReference type="STRING" id="306901.Q2GX72"/>
    <dbReference type="GeneID" id="4394064"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07432"/>
    <dbReference type="eggNOG" id="KOG1121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009123_10_0_1"/>
    <dbReference type="InParanoid" id="Q2GX72"/>
    <dbReference type="OMA" id="WLISANI"/>
    <dbReference type="OrthoDB" id="6619648at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="631"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ86179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="726" mass="83840" checksum="2D48C9F2D386EFFB" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXN7</accession>
    <name>Q2GXN7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enhancer of polycomb-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224923.1">
        <property type="nucleotide sequence ID" value="XM_001224922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXN7"/>
    <dbReference type="STRING" id="306901.Q2GXN7"/>
    <dbReference type="GeneID" id="4394586"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07267"/>
    <dbReference type="eggNOG" id="KOG2261">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010580_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GXN7"/>
    <dbReference type="OMA" id="HIKWNEG"/>
    <dbReference type="OrthoDB" id="435275at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024943">
        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="62940" checksum="8252D64454576706" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GY15</accession>
    <name>Q2GY15_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_07139</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224795.1">
        <property type="nucleotide sequence ID" value="XM_001224794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GY15"/>
    <dbReference type="STRING" id="306901.Q2GY15"/>
    <dbReference type="GeneID" id="4393509"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07139"/>
    <dbReference type="eggNOG" id="ENOG502S1Y5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055310_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GY15"/>
    <dbReference type="OMA" id="SNTGCPR"/>
    <dbReference type="OrthoDB" id="5560525at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF4">
        <property type="entry name" value="GDP_GTP EXCHANGE FACTOR SEC2 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="4">
        <location>
            <begin position="218"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="222"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="85"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ85886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="330" mass="34996" checksum="6CB8AA4F835411F6" modified="2006-03-21" version="1">MTVASPGTLRAAPTQTPCCPNCGFGADLPPFEETQTALLDAQKHISDLQAQVRLLNQKASAAVDRWADYEDELAKLRAQLDARPQTPTSASAATAAQHQQTQKQTSLPTPPSSAAGLPSPSPSRASFLTTSAATRISALLTRKSPPAPVAATPAPTPAPTLPPTLRPLTNIPQQKPSAPSPIPSLPSSASYPPHHHHHHHPNTPPSLPPSAQLTPSDLLSALSREQALRAEAEGRLSETSREVEELSASLFEQANEMVAAERRARARLEQRVGELERREGDKRRRLERLERAVGRIERVRGVLGELEGLEGVVGDGGGNGGGMGSNDGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GY23</accession>
    <name>Q2GY23_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_07131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224787.1">
        <property type="nucleotide sequence ID" value="XM_001224786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GY23"/>
    <dbReference type="GeneID" id="4393712"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07131"/>
    <dbReference type="HOGENOM" id="CLU_1626831_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GY23"/>
    <dbReference type="OrthoDB" id="10492643at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ85878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="163" mass="17255" checksum="979BDE968922DDEC" modified="2006-03-21" version="1">MWVRRSRLALAHGQSLFEGAEAVNNVPNLEATAKPGGGRRSPSNVQIRVCETGRYAEKVCGCGEMVFGSTPALKSTISFVIVDTPGSSTLCLLVFGDDGNRPSSHFVRASIPSMQTGSPEWMTSHRVGQQGALTPGALPIAKQPVVAQAVSRNKADGFSWGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYE0</accession>
    <name>Q2GYE0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_07014</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224670.1">
        <property type="nucleotide sequence ID" value="XM_001224669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYE0"/>
    <dbReference type="STRING" id="306901.Q2GYE0"/>
    <dbReference type="GeneID" id="4394102"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07014"/>
    <dbReference type="eggNOG" id="KOG0141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_4_4_1"/>
    <dbReference type="InParanoid" id="Q2GYE0"/>
    <dbReference type="OMA" id="EQPVMRQ"/>
    <dbReference type="OrthoDB" id="2588832at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="7"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ85761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="516" mass="57575" checksum="3B0D3D10BB2EC4A4" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYT1</accession>
    <name>Q2GYT1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224529.1">
        <property type="nucleotide sequence ID" value="XM_001224528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYT1"/>
    <dbReference type="GeneID" id="4394032"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06873"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1767836_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYT1"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="147" mass="15486" checksum="951D38B3C78129E0" modified="2006-03-21" version="1">MAQATEPSGSADFPGDGFANNLISDLAPLLTLFGEQVTKQFLGMSMGWADNVLLAMGPLGILTIIVSAIRVGGARQLKALVGRARESMATVAPNVPPQTTETQPSGSHSYHGYRRWPFTAQRQRKNVGANLASAADMGGANPSCLSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZ84</accession>
    <name>Q2GZ84_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_05162</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224376.1">
        <property type="nucleotide sequence ID" value="XM_001224375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZ84"/>
    <dbReference type="GeneID" id="4392966"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05162"/>
    <dbReference type="eggNOG" id="ENOG502RS6E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013783_3_2_1"/>
    <dbReference type="InParanoid" id="Q2GZ84"/>
    <dbReference type="OMA" id="NTTMPTF"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208768" description="Peptidase S53 domain-containing protein" evidence="10">
        <location>
            <begin position="20"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="11">
        <location>
            <begin position="199"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ88543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="433" mass="46521" checksum="514F273B2402E81C" modified="2006-03-21" version="1">MRYSLLPALLGLVITSVQAASSVILEQTKGIPPGWSFQGNASASDKITLFVALKEPGLEDLKAKLHQRQNPAHPSFGRHLSRNEVIQHRKPADPAAVSAWLKANGIRDVHDQGSLISFEASAEKVKSLFEADLAYYGYQDSDEGPVLRATSYRIPAWLRDYIEPKPSSTSSAAALSSSPSLVHNPTPEEIFPNLPCLAATVPDCIKKLYNITYTPDSDTPSPVRFGVAGFLEQYIQHSDVDHFLDTFTPNLPPTYNFTTELFHNATNPQHPPSLAGLEASLDIQYALSLGHPTHVIYYLTAGRGTKLDAVTGHPLPTHHSDNEPFLEFLTTLLAKPDSQLPHVLSISYADDEVGVPKAYALRVCDLFAALTARGTTVLAATGDGGAAGTGQTDCVDRETGQKRYVPTFPASCPYVTAVGATENVAPPVAGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZH9</accession>
    <name>Q2GZH9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_05067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224281.1">
        <property type="nucleotide sequence ID" value="XM_001224280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZH9"/>
    <dbReference type="GeneID" id="4392296"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05067"/>
    <dbReference type="HOGENOM" id="CLU_953167_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZH9"/>
    <dbReference type="OMA" id="RCIVARW"/>
    <dbReference type="OrthoDB" id="4589250at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ88448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="32578" checksum="CF5EFF79102687B7" modified="2006-03-21" version="1">MANHLLRERDAPPVGKLWAHNFVKRQPQLRTRRTRRYDYQRAKAKYGIVDDDVYNFDETGLMMGIIFAGQAYGRLIDELMRAHINHITKLEFLCAFREAFFASMTEKNIQGGFAGAGIIPFDPESVLSKLDVKLHAPTPPDSLPGTAQPWVSMTPYNTQETRSQSDFIKTRISSYQNSSPASVLVAVDQLTKGATAVMHQVALLQSEVSSLRKANEVLSKRRKAKRTRIQLGGALTVQDAQDPLDQRDVGKGALQETQPDSSGAGGARAKVRRCIVARWEKARRSLICVARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZS2</accession>
    <name>Q2GZS2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Elongation factor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Eukaryotic elongation factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_04974</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224188.1">
        <property type="nucleotide sequence ID" value="XM_001224187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZS2"/>
    <dbReference type="FunCoup" id="Q2GZS2">
        <property type="interactions" value="622"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GZS2"/>
    <dbReference type="GeneID" id="4392674"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04974"/>
    <dbReference type="eggNOG" id="KOG0062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002848_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZS2"/>
    <dbReference type="OMA" id="VLSEAMW"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000001">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040533">
        <property type="entry name" value="EF3_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047036">
        <property type="entry name" value="EF3_4HB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF5">
        <property type="entry name" value="ELONGATION FACTOR 3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17947">
        <property type="entry name" value="4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="repeat" description="HEAT" evidence="15">
        <location>
            <begin position="95"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="15">
        <location>
            <begin position="175"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="434"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="677"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="980"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="981"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1031"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00050030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050045"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ88355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1053" mass="116519" checksum="BC0DCC19E9AED29A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZY7</accession>
    <name>Q2GZY7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_04909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224123.1">
        <property type="nucleotide sequence ID" value="XM_001224122.1"/>
    </dbReference>
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    <dbReference type="STRING" id="306901.Q2GZY7"/>
    <dbReference type="GeneID" id="4391589"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04909"/>
    <dbReference type="eggNOG" id="ENOG502TDGP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_980057_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZY7"/>
    <dbReference type="OrthoDB" id="5430299at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ88290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="284" mass="31680" checksum="796F5505FAB28012" modified="2006-03-21" version="1">MHSLLDIDLDMPWSPSDRLPGLRDQIRGQDFNTASIIFSRLQANRDPEELEALYKGARYPVGDLQLTAEEFARQVDSMNFHSSKACYKLIKSMGVLIPIGFDGPIIYRLIVHPWELRPHLLEDDVASLFDMSQWSEWSEPSASSCDSLLPSYFLGVNLTVKPCQPPCDGPGNPSEISTRSVESADADVDAPGFTFFQLGDLEYTGRTNGREGPWLDSNEERAYSSYIEGWAETGFVVVARLNPSGRTDGIYVVYDMCRDIAARKDPEYPSAKETKIIDSHSAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0A7</accession>
    <name>Q2H0A7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Shikimate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_04789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224003.1">
        <property type="nucleotide sequence ID" value="XM_001224002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0A7"/>
    <dbReference type="STRING" id="306901.Q2H0A7"/>
    <dbReference type="GeneID" id="4391681"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04789"/>
    <dbReference type="eggNOG" id="KOG0692">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_645572_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H0A7"/>
    <dbReference type="OrthoDB" id="4415835at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF17">
        <property type="entry name" value="QUINATE REPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ88170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="48266" checksum="CB5719FEBFAEBE8F" modified="2006-03-21" version="1">MAPPRNERVFEPNASIVLVGCRGAGKRTLGFMGALHLRRRLVTEDHYFEKITGLSRGQYLARHGRDHFARQNIEVFKRMLDTNRSGCIIECGMSSFSEEAQDALREYSRTNPVVYIHREKEQIARLMDPGDAQQLLEADSKHRNCSNFEYYNPLRLLPLLPLHRGPPSGTSTPMNGLQPGPSKLLSVQEGFAKFLDIITGRGATKAWLESPFSVAAVPPEFRSYSYSLRLRLSYLMDMDLEWEDFEARGDCVELIIDHWPDDLLNVVARQVALIRRKLGVPIIYHVEENPRGERRKASRRERCNGCGAARVSLGEPSHAAPGQIPRSSATIGTWGLGRSPWQDEQQMVNYRRAQALGCDVVRMVRFCANDSPVEYLDHFKKRLNNAIPDPKPPHRRLRLLRPRRAYPIANSHTWSGKAPGHGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0Q1</accession>
    <name>Q2H0Q1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair protein S5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_04645</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
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        <property type="protein sequence ID" value="EAQ88026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223859.1">
        <property type="nucleotide sequence ID" value="XM_001223858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0Q1"/>
    <dbReference type="FunCoup" id="Q2H0Q1">
        <property type="interactions" value="664"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H0Q1"/>
    <dbReference type="GeneID" id="4391689"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04645"/>
    <dbReference type="eggNOG" id="KOG1979">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004131_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H0Q1"/>
    <dbReference type="OMA" id="MCLIQHE"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03483">
        <property type="entry name" value="MutL_Trans_MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="7">
        <location>
            <begin position="94"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ88026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="540" mass="58776" checksum="E2B1D5484A3667A4" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0R8</accession>
    <name>Q2H0R8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Folliculin-interacting protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223842.1">
        <property type="nucleotide sequence ID" value="XM_001223841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0R8"/>
    <dbReference type="STRING" id="306901.Q2H0R8"/>
    <dbReference type="GeneID" id="4392911"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04628"/>
    <dbReference type="eggNOG" id="ENOG502QUW1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007239_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H0R8"/>
    <dbReference type="OMA" id="HWDVITR"/>
    <dbReference type="OrthoDB" id="5428015at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028084">
        <property type="entry name" value="FNIP_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21634">
        <property type="entry name" value="RE13835P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21634:SF9">
        <property type="entry name" value="RE13835P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14636">
        <property type="entry name" value="FNIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Folliculin-interacting protein N-terminal" evidence="2">
        <location>
            <begin position="114"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="972"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1092"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="864"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1092"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1113"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1127"/>
            <end position="1140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1226" mass="133103" checksum="A9449E529BDF7558" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0W7</accession>
    <name>Q2H0W7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Exoribonuclease phosphorolytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_04579</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223793.1">
        <property type="nucleotide sequence ID" value="XM_001223792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0W7"/>
    <dbReference type="FunCoup" id="Q2H0W7">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H0W7"/>
    <dbReference type="GeneID" id="4393072"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04579"/>
    <dbReference type="eggNOG" id="KOG1068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063514_1_2_1"/>
    <dbReference type="InParanoid" id="Q2H0W7"/>
    <dbReference type="OMA" id="MCCVYGP"/>
    <dbReference type="OrthoDB" id="2504340at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11371">
        <property type="entry name" value="RNase_PH_MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
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        <property type="project" value="TreeGrafter"/>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the non-repetitive/WGA-negative nucleoporin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223452.1">
        <property type="nucleotide sequence ID" value="XM_001223451.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2H1V8">
        <property type="interactions" value="1083"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H1V8"/>
    <dbReference type="GeneID" id="4391737"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04238"/>
    <dbReference type="eggNOG" id="KOG1900">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000429_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H1V8"/>
    <dbReference type="OMA" id="SWAPFQK"/>
    <dbReference type="OrthoDB" id="338970at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051292">
        <property type="term" value="P:nuclear pore complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.440:FF:000001">
        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.450:FF:000002">
        <property type="entry name" value="Putative non-repetitive nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1880">
        <property type="entry name" value="Nucleoporin, helical C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.440">
        <property type="entry name" value="Nucleoporin, helical domain, central subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.450">
        <property type="entry name" value="Nucleoporin, helical domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004870">
        <property type="entry name" value="Nucleoporin_Nup155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042533">
        <property type="entry name" value="Nucleoporin_Nup155_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042537">
        <property type="entry name" value="Nucleoporin_Nup155_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042538">
        <property type="entry name" value="Nucleoporin_Nup155_C_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="14">
        <location>
            <begin position="148"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="13">
        <location>
            <begin position="692"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ87619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1436" mass="158422" checksum="26DC559060C80AF0" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1Z4</accession>
    <name>Q2H1Z4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Cytochrome b-c1 complex subunit Rieske, mitochondrial</fullName>
            <ecNumber evidence="12">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_04202</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="12">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="12">The Rieske protein is a high potential 2Fe-2S protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="12"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223416.1">
        <property type="nucleotide sequence ID" value="XM_001223415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1Z4"/>
    <dbReference type="FunCoup" id="Q2H1Z4">
        <property type="interactions" value="686"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H1Z4"/>
    <dbReference type="GeneID" id="4392652"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04202"/>
    <dbReference type="eggNOG" id="KOG1671">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H1Z4"/>
    <dbReference type="OMA" id="PPYDFND"/>
    <dbReference type="OrthoDB" id="1637982at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03470">
        <property type="entry name" value="Rieske_cytochrome_bc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.270">
        <property type="entry name" value="Ubiquinol cytochrome reductase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037008">
        <property type="entry name" value="bc1_Rieske_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006317">
        <property type="entry name" value="Ubiquinol_cyt_c_Rdtase_Fe-S-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01416">
        <property type="entry name" value="Rieske_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81502">
        <property type="entry name" value="ISP transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rieske" evidence="15">
        <location>
            <begin position="135"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAQ87583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="231" mass="24657" checksum="53694F824000A345" modified="2006-03-21" version="1">MAPLQTVSRALTRSATAAACRSPATATAVRAMSSTPALRDSSSSSSSYQSPFKGESKTNVPDFSKYMSKGSGSTNALFSYFMVGTLGAISAAGAKSTIQPRCFGPWPKVEVDLAAIPEGKNVIIKWRGKPVFIRHRTAAEIDEANSINVASLRDPETDDQRVKKPEWLVMLGVCTHLGCVPIGEAGDFGGWFCPCHGSHYDISGRIRKGPAPLNLEIPTYDFSDDGKLVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H275</accession>
    <name>Q2H275_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_04121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223335.1">
        <property type="nucleotide sequence ID" value="XM_001223334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H275"/>
    <dbReference type="STRING" id="306901.Q2H275"/>
    <dbReference type="GeneID" id="4391973"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04121"/>
    <dbReference type="HOGENOM" id="CLU_745963_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H275"/>
    <dbReference type="OrthoDB" id="4763081at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ87502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="371" mass="42426" checksum="46F5CDD88A47EE7A" modified="2006-03-21" version="1">MADPGPDVLFTRTVSKFSCAIAPPATRWTFSGRRVHGAVFPGSVPPSRRYDTLPQVVIGTILEWLSRDDCFWRCVTAMHMAQSLSMVTERPLRIIPLSWLVSWERGSPPKVASEEAAEGLVRFIRFTIDRDGMSKFERMSERPQFNRERFDDKVFVVEREDVFGASLAMFKEYKWSVWDTPTPPDLAPYLARPEKPLSMLRYHSINLAAVTGITFFVFFGRVFGVHAHSRAQPCAMASYQAYGKRRRREMDNHCAWVYVPLASGDTVRALGQCQLHVDPSDTFERPFRIAFLNVTTFPGYTEVLFDKLPSADDPQLDDWLYYEMAGTLNFWFSTSQGHMAVQGGREIPQTDLWEEVPPEELLLMKQVGEDS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2J1</accession>
    <name>DBP4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent RNA helicase DBP4</fullName>
            <ecNumber>3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DBP4</name>
        <name type="ORF">CHGG_04005</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent RNA helicase required for ribosome biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal complexes. Required for pre-rRNA cleavage at site A2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with the U3 and U14 snoRNAs. Associates with pre-ribosomal complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223219.1">
        <property type="nucleotide sequence ID" value="XM_001223218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2J1"/>
    <dbReference type="SMR" id="Q2H2J1"/>
    <dbReference type="FunCoup" id="Q2H2J1">
        <property type="interactions" value="915"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H2J1"/>
    <dbReference type="GeneID" id="4391717"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04005"/>
    <dbReference type="eggNOG" id="KOG0343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_26_1_1"/>
    <dbReference type="InParanoid" id="Q2H2J1"/>
    <dbReference type="OMA" id="YDKMFER"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17941">
        <property type="entry name" value="DEADc_DDX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000256000" description="ATP-dependent RNA helicase DBP4">
        <location>
            <begin position="1"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="84"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="284"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="508"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="676"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box">
        <location>
            <begin position="206"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="677"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="700"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="730"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="761"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="805"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="97"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="825" mass="91324" checksum="52D67004262A40A3" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H379</accession>
    <name>Q2H379_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_03767</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222981.1">
        <property type="nucleotide sequence ID" value="XM_001222980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H379"/>
    <dbReference type="STRING" id="306901.Q2H379"/>
    <dbReference type="GeneID" id="4391978"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03767"/>
    <dbReference type="eggNOG" id="KOG3318">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2014994_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H379"/>
    <dbReference type="OrthoDB" id="369569at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ87148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="123" mass="13398" checksum="04573AB21F29FE3D" modified="2006-03-21" version="1">MSATATTTLPAWVAGLNNPPAHKSKQAGIPDPPGYPSSQSPSNSKVELPRSLHQVQAVNSIMMVFMAFKNPIMGILGTNQAFERFETEGNRAKMLQVKLATTRSDWLAWEAQREAVEHAVPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3P2</accession>
    <name>Q2H3P2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222818.1">
        <property type="nucleotide sequence ID" value="XM_001222817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3P2"/>
    <dbReference type="STRING" id="306901.Q2H3P2"/>
    <dbReference type="GeneID" id="4391070"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06723"/>
    <dbReference type="eggNOG" id="ENOG502SJXH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083369_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H3P2"/>
    <dbReference type="OMA" id="TKNCQLH"/>
    <dbReference type="OrthoDB" id="152248at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025649">
        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847:SF1">
        <property type="entry name" value="PSEUDOURIDINE SYNTHASE RSUA_RLUA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208914" description="Secreted protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="22999" checksum="FCF7FD831AEAB474" modified="2006-03-21" version="1">MRSVAILLPALVAASPIAQVVGNDGWADAPDPKDIQIVAATFSGNGCPQGSVSTNISPDKTVITFGFDKFQTYIGPGISPIEKSKNCQLHLSLKYPGGFQFSVLESTYHGYAQLEKGVTGNFYSTYYFSQDAQATTTTQTSITGGGIWEQGQVYTKADQIPTASYIFSPCGANGILNINNRIALTSTNSSASGLITDDDATVAFTQQVNIAWRSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3P6</accession>
    <name>Q2H3P6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane BAX inhibitor motif-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_06719</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222814.1">
        <property type="nucleotide sequence ID" value="XM_001222813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3P6"/>
    <dbReference type="FunCoup" id="Q2H3P6">
        <property type="interactions" value="526"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H3P6"/>
    <dbReference type="GeneID" id="4391354"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06719"/>
    <dbReference type="eggNOG" id="KOG2322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058671_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3P6"/>
    <dbReference type="OMA" id="FGVMSLY"/>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10429">
        <property type="entry name" value="GAAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF50">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ90100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="31005" checksum="BE0AB70A48B75D55" modified="2006-03-21" version="1">MSTNVKYTPAPQEDPELNYTQPPPSYQAESSSAQDQERLFGSPRNSEDNVPDDFKFGGSVAEATVEIRNQFIRKVYTILTVQLIATGAVSALSFMSDSYKSWIQSHPAIVWVSLFGSMACMMLTYWKRHSYPTNLLFLSAFTLLEAYTISVIVSFYSASIVLNAVFLTAGIFLFLTAFACQTKYDFTSWMPYLFGALWGLVIFGFMSFFLPHTSTTELVYGLLTALIFSGYVLVDTQLVLRKHHVEEEIAAAISLYLDIINLFLAILRILNSQSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H438</accession>
    <name>Q2H438_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongator complex protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_06577</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222672.1">
        <property type="nucleotide sequence ID" value="XM_001222671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H438"/>
    <dbReference type="STRING" id="306901.Q2H438"/>
    <dbReference type="GeneID" id="4391094"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06577"/>
    <dbReference type="eggNOG" id="ENOG502QSI3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059771_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H438"/>
    <dbReference type="OMA" id="LYFIQRD"/>
    <dbReference type="OrthoDB" id="9995306at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018627">
        <property type="entry name" value="ELP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ89958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="29590" checksum="77EC0510BAE91943" modified="2006-03-21" version="1">MTSRIPHLLEPHLALPPESSLITLTSVLGASTNWLVLRHLHALLKPAAPSPHNQQQQQQQRHQNSHQPAPGDEGEVAVLLRKVRQGWEVGVGGRGAGEIGRVVLEGVERLRRSSSITSSAAAAAAAARGGERERAEKRVVLVIDGLDFVLAALDPSLGLGQGLQGAGDAPGTAIAMKEMLMELREKTHAVIITLAADDPLIKEQETTLEKQHAWFALSLAHEAGMVISLRLLDTGTAKDVSGVIRITHREARVKDHEYLYHVGGDGGVRVFERGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H460</accession>
    <name>Q2H460_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">diacylglycerol cholinephosphotransferase</fullName>
            <ecNumber evidence="9">2.7.8.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_06555</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>CDP-N,N-dimethylethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33775"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:65117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:33776"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.2" evidence="9"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222650.1">
        <property type="nucleotide sequence ID" value="XM_001222649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H460"/>
    <dbReference type="FunCoup" id="Q2H460">
        <property type="interactions" value="541"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H460"/>
    <dbReference type="GeneID" id="4390862"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06555"/>
    <dbReference type="eggNOG" id="KOG2877">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035066_5_2_1"/>
    <dbReference type="InParanoid" id="Q2H460"/>
    <dbReference type="OMA" id="QNMGQGW"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004142">
        <property type="term" value="F:diacylglycerol cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101026">
        <property type="term" value="P:mitotic nuclear membrane biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000012">
        <property type="entry name" value="sn-1,2-diacylglycerol cholinephosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ89936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="419" mass="46612" checksum="C8C407A8A9E570B5" modified="2006-03-21" version="1">MVYVRQEYLPNLRQYKYSAVDHSLLSRYVLKPFYTNVVIKCFPMSMAPNLITLTGFMFVVANFLTLLWYNPTLDQDCPTWVYYSWAAGLFLYQTFDAVDGTQARRTHQSGPLGELFDHGVDALNTCLEVLLFAGATNMGQSWKTVATLFASLLTFYVQTWDEYHTKTLTLGIVNGPVEGILTVVIVYLLTGFFGGASFWNQGMLATVGVPQAVASGVTIPDCVYNLSFTEWYMVQGTVVLVYNTVESARNVIRARRARGDRSRYALVGLGPFFAAWAFIVAYLYLQPTILHGHLIPFAVFAGMVNAYSVGQMITAHLVKLPFPYWNVMVIPLSCGVIDSLGPVLLRHSPVPGLGWPSALGDGVYQVAFMFCMLGMAVGVYGSFVVDVIVTICDYLDIWCLTIKHPWVEGQDGTADKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4J8</accession>
    <name>Q2H4J8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isovaleryl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_06417</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222512.1">
        <property type="nucleotide sequence ID" value="XM_001222511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4J8"/>
    <dbReference type="STRING" id="306901.Q2H4J8"/>
    <dbReference type="GeneID" id="4390853"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06417"/>
    <dbReference type="eggNOG" id="KOG0141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H4J8"/>
    <dbReference type="OMA" id="CFITNSG"/>
    <dbReference type="OrthoDB" id="9988775at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000021">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase IvdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000003">
        <property type="entry name" value="isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000004">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF18">
        <property type="entry name" value="ISOVALERYL-COENZYME A DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="67"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="181"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="288"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ89798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="47745" checksum="326C03E50D4953E8" modified="2006-03-21" version="1">MSSSTLSRALPRATRINAAITRRQFGLGSSITSSGRAVTPAIICQQQRRNASSKHPKDFEPPSPSDLAELRERVQEFTRRELTEEVASATDKNNKFPADMWGKLGEAGFLGITADEDVGGLAMGYQAHCVVMEELSRASGSIALSYAAHSQLCVNQLQLNGSPEQKQKYLPGLISGEKVGALAMSESGSGSDVVSMRTRAKEVDGGYILNGSKMWITNGPDADVVVVYAKTVPDGGSKGITAFIVDTASPGFTCLRKLDKMGMRGSNTGELVFENLFVPAENVLGAVNGGVRVLMEGLDLERLVLSAGPLGLMQAALDVALPYAHTRKQFGTPVAQFQLVQGKLADMYTKLQASRAYTYATARAVDEQGLIRTQDCAGAILYAAERATECALDAIQVLGGMGYVEEMPASRIMRDAKLYEIGAGTSEVRRMVIGRAFNKEYGHLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4T4</accession>
    <name>Q2H4T4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome quality control complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_06331</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NEMF family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222426.1">
        <property type="nucleotide sequence ID" value="XM_001222425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4T4"/>
    <dbReference type="FunCoup" id="Q2H4T4">
        <property type="interactions" value="891"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H4T4"/>
    <dbReference type="GeneID" id="4389943"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06331"/>
    <dbReference type="eggNOG" id="KOG2030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003612_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H4T4"/>
    <dbReference type="OMA" id="MFLEFFA"/>
    <dbReference type="OrthoDB" id="207084at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.310.10:FF:000003">
        <property type="entry name" value="Zinc knuckle domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.310.10">
        <property type="entry name" value="ibrinogen binding protein from staphylococcus aureus domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021846">
        <property type="entry name" value="NFACT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11923">
        <property type="entry name" value="NFACT-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05833">
        <property type="entry name" value="NFACT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="8">
        <location>
            <begin position="553"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="NFACT protein C-terminal" evidence="9">
        <location>
            <begin position="949"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="446"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="706"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="900"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="506"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="706"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="729"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="781"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="800"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="839"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="900"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ89712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1115" mass="123042" checksum="7DA6CAAF89135138" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4U7</accession>
    <name>Q2H4U7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">OPT family small oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_06318</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222413.1">
        <property type="nucleotide sequence ID" value="XM_001222412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4U7"/>
    <dbReference type="FunCoup" id="Q2H4U7">
        <property type="interactions" value="80"/>
    </dbReference>
    <dbReference type="GeneID" id="4390204"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06318"/>
    <dbReference type="eggNOG" id="KOG2262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004965_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H4U7"/>
    <dbReference type="OMA" id="AMIWPAD"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="589"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="632"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="661"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="684"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="706"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="734"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="833"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ89699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="871" mass="99690" checksum="FEB799CCEBFB7984" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4Z1</accession>
    <name>Q2H4Z1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">ATP synthase subunit d, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_06274</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ATPase d subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222369.1">
        <property type="nucleotide sequence ID" value="XM_001222368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4Z1"/>
    <dbReference type="FunCoup" id="Q2H4Z1">
        <property type="interactions" value="437"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H4Z1"/>
    <dbReference type="GeneID" id="4391062"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06274"/>
    <dbReference type="eggNOG" id="KOG3366">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080463_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4Z1"/>
    <dbReference type="OMA" id="VSKGRWA"/>
    <dbReference type="OrthoDB" id="35799at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008689">
        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12700">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005514">
        <property type="entry name" value="ATPase_F0_D_mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161065">
        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0138">CF(0)</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ89655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="173" mass="19443" checksum="AE009D89B514D7A3" modified="2006-03-21" version="1">MAARSAALKVDWAKITTSLGLRGQTVAGLQAFKKRNDDVRRKVQLLSEQPTTVDFSQYRAVLKNQAIVDEIEKRFNAFQPATYDLSRQLKAIDAFEVEAVQNAQATKQKVDLELKDLEKTLKNIEEARPFEDLTVDEVAAAEPSIDEKTSKLVSKGRWSVPGYKERFGDLSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H546</accession>
    <name>Q2H546_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA 3'-terminal phosphate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_06219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222314.1">
        <property type="nucleotide sequence ID" value="XM_001222313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H546"/>
    <dbReference type="STRING" id="306901.Q2H546"/>
    <dbReference type="GeneID" id="4390356"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06219"/>
    <dbReference type="eggNOG" id="KOG3980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027882_3_1_1"/>
    <dbReference type="InParanoid" id="Q2H546"/>
    <dbReference type="OMA" id="HAKTARW"/>
    <dbReference type="OrthoDB" id="25029at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003963">
        <property type="term" value="F:RNA-3'-phosphate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF0">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="491" mass="52685" checksum="39BFDA28ECF42B39" modified="2006-03-21" version="1">MAKTIPVIEIDGRTGEGGGQLVRIACALAAVASQPVRITNVRGGRGGGGGLKSQHVTAIQYLAKATAADVSGLSVGSQKVEFHPQLRPSDLTSRNIKIEADSPAASTMLIFQAVFPFLLLAGNGKGDPIRLEISGGTNVSFSLSFEYLDQVLLPTLQDAFGIRVERKLISRGWSLGKQQRGKVQFRFTPLKRGEPLRLREEGDVYGGDGPQLSVSDVEAIDVTMIVPAEMHDSLEEALRETLATLFGDVEVEFRLKEDSGADSRIYVLLVAHAREGKVRWGKDVLRSMPKKPRDKGKGGQSNPSALSQSISNDVAKKLYEEVNYGGVVDEHLQDQLVIFQALAEGRTSFPRTTAKDDLEQSMAKLAMNGKMPSVAIRGCRRRRLARSTNSESPLDPTIRRVVRHPAPCVPQLMLRRAHSLTSPAGMESTGPGLTGMVSTCCKSDSSLEASSVNCCGSVGETASQDRACRLAPTPSGVDGLGNRSHLTSIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5D2</accession>
    <name>Q2H5D2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CHGG_06133</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222228.1">
        <property type="nucleotide sequence ID" value="XM_001222227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5D2"/>
    <dbReference type="FunCoup" id="Q2H5D2">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="GeneID" id="4389971"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06133"/>
    <dbReference type="eggNOG" id="ENOG502SKG6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_6_3_1"/>
    <dbReference type="InParanoid" id="Q2H5D2"/>
    <dbReference type="OMA" id="LNMTYTY"/>
    <dbReference type="OrthoDB" id="2496787at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF143">
        <property type="entry name" value="EXTRACELLULAR MEMBRANE PROTEIN CFEM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208824" evidence="16">
        <location>
            <begin position="22"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="17">
        <location>
            <begin position="29"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="18">
        <location>
            <begin position="140"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="416"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAQ89514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="529" mass="56234" checksum="E74FAC1EA736B2EA" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5P3</accession>
    <name>Q2H5P3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_06022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222117.1">
        <property type="nucleotide sequence ID" value="XM_001222116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5P3"/>
    <dbReference type="GeneID" id="4390462"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06022"/>
    <dbReference type="eggNOG" id="ENOG502SXTT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1559055_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5P3"/>
    <dbReference type="OMA" id="HEYIKSN"/>
    <dbReference type="OrthoDB" id="4558637at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="21081" checksum="3369A87F10BAC90D" modified="2006-03-21" version="1">MENSLTEPAEGGKADGETEIGYMYMFEADEEKLPPFEKPNGIRILKKINKPFKPPEVGIPPYIVDCYGHEYIKSNHGDPGGASMYHSVSYWKLCNGESIKTRWQTPAINSPWIPTSILVRMIRQVLSMFQWLYTAGDQPVYHGDAHMGNIWIHWPEDTMLPDFYLGDFGHARFADEEILLDLEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5Q1</accession>
    <name>Q2H5Q1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ferric reductase NAD binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_06014</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222109.1">
        <property type="nucleotide sequence ID" value="XM_001222108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5Q1"/>
    <dbReference type="GeneID" id="4390532"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06014"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_703987_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5Q1"/>
    <dbReference type="OMA" id="CKASKTH"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF3">
        <property type="entry name" value="REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric reductase NAD binding" evidence="5">
        <location>
            <begin position="216"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="295"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ89395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="392" mass="43146" checksum="35B83E215F81976E" modified="2006-03-21" version="1">MALTPRHIQNMSEAAALEPHWGYADRAVPCTNDPGSCAYLDVVYGAHDRGMIYTGIFWLTIGGILLVWAISRRLFPAREPHDDLLAQLSAAQKEKQKQPNTTTITTTDPESQPPQITTTRNRHSSRGVLGQHFFLCFTEGSIFQSPPVHAAVTARWRMPLGRVRHSYIFRAKGGETKKIADVLVKKAAAGTALATSVIMQGPYGENIAEGLTQDVNVLCVAGGTGITYVLPVLLRLVREKPAPGRKLELVWAVKRRQDLEWVEPEMEELRRLGAAHDLRIRTFVTSEPLTVTSKEVRVTDDKGRTESDDDIESAQDTPSTRSGTDHRPDVAAAVSDFVAGVAHGQTRVFGSGPVGMVVEMRAAVAKCNSGGKVWKGEERFDVRLVCDDRLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5X8</accession>
    <name>Q2H5X8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222032.1">
        <property type="nucleotide sequence ID" value="XM_001222031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5X8"/>
    <dbReference type="STRING" id="306901.Q2H5X8"/>
    <dbReference type="GeneID" id="4390714"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05937"/>
    <dbReference type="eggNOG" id="ENOG502QQPX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007526_0_2_1"/>
    <dbReference type="InParanoid" id="Q2H5X8"/>
    <dbReference type="OMA" id="MCVYRHP"/>
    <dbReference type="OrthoDB" id="191037at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="30"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="479" mass="51913" checksum="17A505C464B13D00" modified="2006-03-21" version="1">MAGRVRQPIDIGALERWISKNVPQIEVPLDVKQFGFGQSNPTYQLTAADSRRYVLRKKPPGRLLSKTAHKVEREYRIIHALERTDVPVPKAYCLCEDTSVLGTPFYIMEFLDGRIFEDPVIPSVLPDHRRAIWADAVRTLAKLHRIDPRSIGLENFGKPTGFYNRQIATWRSVCDAQAAVRDVETRETVGPLPHFAELMAFFSDERQQPADRGTLIHGDFKIDNLVFHKTEPRVIGILDWEMSTIGHPLSDISNLLTPYFTARLDPRRSVNVHPGFLPRATRGLPAPDEITTLYFSVAAAPSPSNPLPTTSLELTLHHHSHSHSAHLNRHHHRSSNSHSTENPDKRRELQWAQAFNIFRLAAICQGIAARQAGRQASSEQARRYGDARAPLAEFAWELVQSARGEGRLGGGGGGGGGGGQGRGGNGGGEDDEGESEREGEGGDGDDGNGGGGGGGQGHGGGGGGSGGGGEGGKGRQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5Y6</accession>
    <name>Q2H5Y6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase class V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222024.1">
        <property type="nucleotide sequence ID" value="XM_001222023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5Y6"/>
    <dbReference type="STRING" id="306901.Q2H5Y6"/>
    <dbReference type="GeneID" id="4390997"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05929"/>
    <dbReference type="eggNOG" id="KOG1549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_2_1"/>
    <dbReference type="InParanoid" id="Q2H5Y6"/>
    <dbReference type="OMA" id="LVTWQQI"/>
    <dbReference type="OrthoDB" id="420046at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586:SF21">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE (PLP)-DEPENDENT ASPARTATE AMINOTRANSFERASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="1">
        <location>
            <begin position="22"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="400" mass="42923" checksum="017E1706DB367C16" modified="2006-03-21" version="1">MAVALDMDEVRGNFPALAGGNVYFDNAGGSLTLGAVAERIRDYLLNTNVQLGASYATSQVATKRYAEGYAAAAEFIGASPEEVALGPSTTQLLYNVSYALNFQEGDEIIVSIIDHEANIAPWVLLAQRQNLTLKWWHPNTTTTTPTNPTLLASDLPALLTPKTRLVTCTHASNILGTIHDIRAITATVRAHSPHALVCVDAVAYAPHRPIDVRALGADFYTFSWYKVYGPHLALLYASPRALAALRSLGHFFNNHRSLEDKLGLAAAGYELVHALPAVVAYLRGGEGGRWAGVAAQERALQGVLLGWLAGREDVTVYGEGGSSGGGGDGGEDVRVPTVSFTVRGWGSRALVERVEAECEGAVGFRWGSFYSKRLVSEVLGLGEKGVVRVSMVHYNTDEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H699</accession>
    <name>Q2H699_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_05816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221911.1">
        <property type="nucleotide sequence ID" value="XM_001221910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H699"/>
    <dbReference type="GeneID" id="4390962"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05816"/>
    <dbReference type="HOGENOM" id="CLU_2120817_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H699"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="114" mass="12789" checksum="D438923F833BEA69" modified="2006-03-21" version="1">MSVSCLDMLTAQRSNMPHSFLDINDVDARGGRVRRRARDRRDRFISLSEKMTGLVPRTEYRFSDDWLGGLQRGDVAGRPHGKENCTLSPTMGVEGGPLSCTVTCRAKERTNRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6C2</accession>
    <name>Q2H6C2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA topoisomerase</fullName>
            <ecNumber evidence="3 7">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_05793</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 7"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221888.1">
        <property type="nucleotide sequence ID" value="XM_001221887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6C2"/>
    <dbReference type="FunCoup" id="Q2H6C2">
        <property type="interactions" value="802"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H6C2"/>
    <dbReference type="GeneID" id="4391170"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05793"/>
    <dbReference type="eggNOG" id="KOG1956">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002929_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H6C2"/>
    <dbReference type="OMA" id="VIHNVYS"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Topo IA-type catalytic" evidence="9">
        <location>
            <begin position="154"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="493"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ89174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="680" mass="75535" checksum="312A6EEA3A7A6149" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7B3</accession>
    <name>Q2H7B3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_05452</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221547.1">
        <property type="nucleotide sequence ID" value="XM_001221546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7B3"/>
    <dbReference type="STRING" id="306901.Q2H7B3"/>
    <dbReference type="GeneID" id="4391184"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05452"/>
    <dbReference type="eggNOG" id="ENOG502S73V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080664_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H7B3"/>
    <dbReference type="OMA" id="GIQNGMT"/>
    <dbReference type="OrthoDB" id="1601230at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044662">
        <property type="entry name" value="HS1/DABB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178:SF10">
        <property type="entry name" value="STRESS-RESPONSE A_B BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Stress-response A/B barrel" evidence="3">
        <location>
            <begin position="52"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ88833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="177" mass="19784" checksum="ECE583E2A4727D00" modified="2006-03-21" version="1">MLDIAGARPHVWRIAIFVVGLLTLFLFFDPIGFASSSMDAMANRGPGDADTLTHVVMFQFKRDADPAAVDVACAKMMSLKDNCVAQNSKFPYIKSLTGGKDNSIEKLQVGHFTWVSHSIVNDRRSMARHTLFVVQFANADDRNYYVEHDPVHQAFKQEIKPLVEATTVLDFTNGKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8B4</accession>
    <name>Q2H8B4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8B4"/>
    <dbReference type="GeneID" id="4388516"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03540"/>
    <dbReference type="eggNOG" id="ENOG502S130">
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    </dbReference>
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    <dbReference type="InParanoid" id="Q2H8B4"/>
    <dbReference type="OMA" id="KFINICI"/>
    <dbReference type="OrthoDB" id="4842715at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="295"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="812" mass="91019" checksum="14473E0100E44786" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8I4</accession>
    <name>Q2H8I4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91535.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8I4"/>
    <dbReference type="GeneID" id="4389461"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03470"/>
    <dbReference type="HOGENOM" id="CLU_2249820_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8I4"/>
    <dbReference type="OrthoDB" id="10367470at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="104" mass="11542" checksum="90273879E4D1E74D" modified="2006-03-21" version="1">MAQRHVGLLIRYYDDNDKRCKYCGENGISLSFEELKALRARLSSRRDAATLPVDGDTLAGGQHQQPMETEALVSQTRTSRASETENTTLGLEGLQLVKSQEAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8L4</accession>
    <name>Q2H8L4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_03440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001229955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8L4"/>
    <dbReference type="GeneID" id="4389472"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03440"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_23_2_1"/>
    <dbReference type="InParanoid" id="Q2H8L4"/>
    <dbReference type="OrthoDB" id="4368687at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208938" description="Reverse transcriptase domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="4">
        <location>
            <begin position="462"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ91505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="862" mass="94998" checksum="A697811D5B661E3A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H954</accession>
    <name>Q2H954_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229766.1">
        <property type="nucleotide sequence ID" value="XM_001229765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H954"/>
    <dbReference type="STRING" id="306901.Q2H954"/>
    <dbReference type="GeneID" id="4388584"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03250"/>
    <dbReference type="eggNOG" id="ENOG502RXKN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017444_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H954"/>
    <dbReference type="OMA" id="VQVQCLF"/>
    <dbReference type="OrthoDB" id="1911848at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF1">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="267"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="529" mass="59644" checksum="D12A6C368EE508D0" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAS9</accession>
    <name>Q2HAS9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_02675</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229191.1">
        <property type="nucleotide sequence ID" value="XM_001229190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAS9"/>
    <dbReference type="STRING" id="306901.Q2HAS9"/>
    <dbReference type="GeneID" id="4389248"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02675"/>
    <dbReference type="eggNOG" id="KOG0653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020695_9_1_1"/>
    <dbReference type="InParanoid" id="Q2HAS9"/>
    <dbReference type="OMA" id="IQTEIRW"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20568">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="422"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="515"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="519"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ90740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="643" mass="71352" checksum="91FE17F91430EA2A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HB29</accession>
    <name>Q2HB29_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_02575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229091.1">
        <property type="nucleotide sequence ID" value="XM_001229090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HB29"/>
    <dbReference type="GeneID" id="4389296"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02575"/>
    <dbReference type="eggNOG" id="ENOG502S03K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018003_1_3_1"/>
    <dbReference type="InParanoid" id="Q2HB29"/>
    <dbReference type="OMA" id="PMLFGDP"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="41"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ90640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="392" mass="44255" checksum="4D57AAC5366E11B3" modified="2006-03-21" version="1">MTDMTGYDGHPPTQPQNGVTNNTSHSDTAELPALTPNDVVIAVMGVTGSGKTTFISHFAPSARIGHGLESCTSTVNIHKATIGQGTVYLIDTPGFDDTHRSDTDILREVANWLNSAYQSRIKLSGIIYLHRIADNRMSGSAMKNLRMFKRLCGDEALSCVVLATTMWNVIPSPEDGAKREHELITKPEFWAGMVERGSKVLRQDNGAVSAMEIMRYIMSQRRRIDLDIQKEMASGKTLDETSAGREVQSNMETMRRKHEKEMAELRQEMEEARRDHDVRAQREIAAVRAELEEKLKKDRADRDKMRVTLEELRQQRAEELANERAAAHEREMQLSNQMYQAQLDREKATNQANESLMELKLQLAIKEADNKRLEREAAEARERNEGGGCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HB41</accession>
    <name>Q2HB41_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229079.1">
        <property type="nucleotide sequence ID" value="XM_001229078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HB41"/>
    <dbReference type="GeneID" id="4389320"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02563"/>
    <dbReference type="HOGENOM" id="CLU_2573665_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HB41"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="81" mass="9060" checksum="89898E687611DCA5" modified="2006-03-21" version="1">MVPNDAPRGGSPIESGQETGPQLQVRTLPWPFSRDCLRVAPDRRSWPPLKAVHTQYSHKTNRLRWQANADGLSEILGDDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HB82</accession>
    <name>Q2HB82_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229038.1">
        <property type="nucleotide sequence ID" value="XM_001229037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HB82"/>
    <dbReference type="GeneID" id="4389223"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02522"/>
    <dbReference type="HOGENOM" id="CLU_1578332_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HB82"/>
    <dbReference type="OrthoDB" id="10304652at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="169" mass="18113" checksum="B1F7CD9622544FEE" modified="2006-03-21" version="1">MDHTPGSRRLIVGEWRWFDKPPEDAGTQDICNSSCRLRTCMGMPCHHTCKAMAVRFEVNVDLWICLAASHLVSGPGCTVSTESWRKRAQAPSSHSGMSSSGAVLLPPHFFAFVMGDFRMLRRVFPARATTGSGGAARAPPSLPPTGCGNSAPAVSPPGQESSARNAHHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBF5</accession>
    <name>Q2HBF5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_02449</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228965.1">
        <property type="nucleotide sequence ID" value="XM_001228964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBF5"/>
    <dbReference type="STRING" id="306901.Q2HBF5"/>
    <dbReference type="GeneID" id="4388964"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02449"/>
    <dbReference type="eggNOG" id="KOG1175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_3_1"/>
    <dbReference type="InParanoid" id="Q2HBF5"/>
    <dbReference type="OMA" id="FTRIPFH"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF4">
        <property type="entry name" value="ACETOACETYL-COA SYNTHASE (AFU_ORTHOLOGUE AFUA_8G04770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="4">
        <location>
            <begin position="45"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="190"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ90514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="622" mass="68339" checksum="22D1685732418493" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBZ0</accession>
    <name>Q2HBZ0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_02264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228780.1">
        <property type="nucleotide sequence ID" value="XM_001228779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBZ0"/>
    <dbReference type="GeneID" id="4388706"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02264"/>
    <dbReference type="HOGENOM" id="CLU_660560_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HBZ0"/>
    <dbReference type="OMA" id="FADHRCG"/>
    <dbReference type="OrthoDB" id="10498198at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ90329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="416" mass="44698" checksum="151890E0B33CBC11" modified="2006-03-21" version="1">MASSTATITANPAVQLPHDSGSIPVNGAPSKPAHSTSGNPVLSLTGAASPEAKAGVASPETKATRVRGTDSGRRKRRVKTEDTVPGPTVEDEIQHVPELEDEIYRLVERGRLANNKYNQERNKSKKELADALEKLAAVETAREDLEKKLVSSKAEARGLIEAKQNLDKELAAAKQDAASTADARKKLGDELAECKAVLGFSTAAKSKLQKANEKLGKELDAVKTELAGLENTREKLEKDLAAANKGAQDLGNTRAEMEKELATAKGQAAAITEAKGKVEADLAATKAELARVGDAKEKLQRELGEKLIRALQAKAEVDIQLSAAMNDKARSDRELSLLIESKARTEEELGDLRADNAGLVADLKVADADCDALEKQVGDLKREKKALMGKLAARERVVQKAYEMLERGNRRFSEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCI5</accession>
    <name>Q2HCI5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_02069</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221290.1">
        <property type="nucleotide sequence ID" value="XM_001221289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCI5"/>
    <dbReference type="STRING" id="306901.Q2HCI5"/>
    <dbReference type="GeneID" id="4386671"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02069"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_1_1"/>
    <dbReference type="InParanoid" id="Q2HCI5"/>
    <dbReference type="OMA" id="RQEMYIG"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012881287" description="Cytochrome P450" evidence="8">
        <location>
            <begin position="16"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ93834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="58411" checksum="AF748B284583CA44" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCN7</accession>
    <name>Q2HCN7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_02017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221238.1">
        <property type="nucleotide sequence ID" value="XM_001221237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCN7"/>
    <dbReference type="GeneID" id="4388314"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02017"/>
    <dbReference type="HOGENOM" id="CLU_2589541_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCN7"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ93782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="80" mass="9209" checksum="38B595DBC4F8AB4D" modified="2006-03-21" version="1">MSHRQEFKARVERSCHGATENWHGTGFLTASLVEGLKSWLEGEKPIEAIKVLRLLAIKVRRHSRVKIARSLGKEWTNQML</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCY7</accession>
    <name>Q2HCY7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221138.1">
        <property type="nucleotide sequence ID" value="XM_001221137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCY7"/>
    <dbReference type="STRING" id="306901.Q2HCY7"/>
    <dbReference type="GeneID" id="4386448"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01917"/>
    <dbReference type="eggNOG" id="KOG2817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_577453_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCY7"/>
    <dbReference type="OrthoDB" id="1933281at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF3">
        <property type="entry name" value="GH10162P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="51"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="473" mass="51850" checksum="0E72A36E25FEF378" modified="2006-03-21" version="1">MDEDEDEDEDEGEDGDAEAEEAHTNTAGFSDVHDSDEYDLSSLHSQELQEKFAEMYTILQQLKAQNLLPAIEWARSNSAELEARGSNLEFELSKLQYVWLFKGPSVNNLPDDENNGRRGALAYARQHFGRFQARHLREIQQLASAMVFAPNLPDSPYHLTFASVSTAFTDVAASFTREFCSLLGLSAESPLYLAVTAGALALPRLMKFMLATRSKGTEWTTTQELPFETPLPQSMLFHSIFVCPVSKEQTTEDNPPMGGADSTGGRRVGRRAGLGHDGAYDDGAHQQGPAPGSGDVDVSLALVIDRVFDGLFQDADSPRPLESFLQPGGELLNAVSGAATSLPDPETLHGVYNTLDSWDAFFAYQQAVGAGERPVHSDPERHHSPGEMRGYRDSEELGVFEEAETDRERDPIDSAVTDGVRFLHLGVGWGEGDVIEADVDGLDAVPHEEFRIRYVEDGATLSEWGSESDSESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDN3</accession>
    <name>Q2HDN3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220892.1">
        <property type="nucleotide sequence ID" value="XM_001220891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDN3"/>
    <dbReference type="GeneID" id="4387912"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01671"/>
    <dbReference type="HOGENOM" id="CLU_1669178_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HDN3"/>
    <dbReference type="OrthoDB" id="10428005at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="158" mass="16930" checksum="0EDE17D62B4FADB3" modified="2006-03-21" version="1">MVEAKLDPAQVLRLGGWSQAGREPIAGVCRARVPVGDIDAMCRDEMRGHTATLRMVSGDSTEEVGPPPTVIDLPIKTHGARGCRARHTQPSPPSQHSREDVGIFPATQRHQFGAAPRGVGPATRPLASHGRRGAREAPLLPGTPRTSSHRSPRARHNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HER1</accession>
    <name>Q2HER1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220514.1">
        <property type="nucleotide sequence ID" value="XM_001220513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HER1"/>
    <dbReference type="STRING" id="306901.Q2HER1"/>
    <dbReference type="GeneID" id="4388226"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01293"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028281_6_1_1"/>
    <dbReference type="InParanoid" id="Q2HER1"/>
    <dbReference type="OMA" id="DERHETS"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF6">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="74"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="348" mass="38700" checksum="B508B12F03D4E490" modified="2006-03-21" version="1">MATPEHLVKFDERHETSQTYTVPPPWKGPEHCHVEFCIFSNPESGEGMSLVTTSRSAFAVAIAETPLSTGLEAGSFYEAEIPGKGSGLIANRTIRKGEIIMERPPALLIQAEPHVDLEPEVRDEVYQAAVDRLPEPARARFLRQVGSTIYDKVERNSFRIFVDGDRKHSAHLGVFPEVSKFNHDCRPNVHYRLNGLKHTTIAVRDIPAGDELTISYIYGRASHATRQSQLREWGFTCTCPQCTLNATETGASDNRLRQIEALETEIERIMGARGAAGLRPEMGGKLVELYRAERLDAYLAPAYTRAALIYAMFAEAERAREFAAEAVGALERETGPWAKDVQSIEMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HES0</accession>
    <name>Q2HES0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220505.1">
        <property type="nucleotide sequence ID" value="XM_001220504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HES0"/>
    <dbReference type="GeneID" id="4387407"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01284"/>
    <dbReference type="eggNOG" id="ENOG502QWA6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009942_5_0_1"/>
    <dbReference type="InParanoid" id="Q2HES0"/>
    <dbReference type="OMA" id="ANDFHST"/>
    <dbReference type="OrthoDB" id="3501663at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF20">
        <property type="entry name" value="AMIDOHYDROLASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="1">
        <location>
            <begin position="64"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="414" mass="44445" checksum="7AB949022CDC0631" modified="2006-03-21" version="1">MATHLFTNGKIFQSGVPPGTNAGLHGQPTFASCMLTHNSQILHIGAPTDAAITTATTTLPPPTVHDLRGRTILPGFVDGHMHLMLLGQALNKLDLGRCANLSDIQAAIRAHAAANPAAPRLLARGWMHSMTPAGRHATDLDGLDVEGRDRPVLVDSKDLHSTWCNSAGVEELGAEGWVDVPGGVIERDGAGRVTGVFSEAANITYVWPYLASVASMEERVGAIEAAVRAYHEAGYTGMVDMAMDEGGWDALLAARRKREGEGGALPMRIAAYWLVKPCEEEGETLQQVERAIELAGEFNAETTPDCRIVGIKPYAHNGHTEVPLWTAEQLEPVVKKADEAGLQIALHAIGDATMKMVVDILTKFARPGRRPRVEHLELTTEEDVARLGKGRITASIQPVHADPAILKAWPKLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HF24</accession>
    <name>Q2HF24_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_01180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220401.1">
        <property type="nucleotide sequence ID" value="XM_001220400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HF24"/>
    <dbReference type="STRING" id="306901.Q2HF24"/>
    <dbReference type="GeneID" id="4386323"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01180"/>
    <dbReference type="eggNOG" id="ENOG502S8IP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071330_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HF24"/>
    <dbReference type="OMA" id="QCIANDN"/>
    <dbReference type="OrthoDB" id="3535423at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF9">
        <property type="entry name" value="EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ92945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16244" checksum="AA1A3017122E902E" modified="2006-03-21" version="1">MKVIVTGCNGLVGSALVRQCIANDNISHVFALTRKPLDEAVAKSTKVTVILHDDFSTYPPALLSQLAGAEACLWAIGGRATQFPDIETYRRVSIDYTLAGARAFQEALVPQLPEGKQFRFLFCSGKFAEWDQDKPLHFMADTRHVKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFV1</accession>
    <name>Q2HFV1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220124.1">
        <property type="nucleotide sequence ID" value="XM_001220123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFV1"/>
    <dbReference type="STRING" id="306901.Q2HFV1"/>
    <dbReference type="GeneID" id="4386355"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00903"/>
    <dbReference type="eggNOG" id="ENOG502SANZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059580_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HFV1"/>
    <dbReference type="OMA" id="DETPHRI"/>
    <dbReference type="OrthoDB" id="5345504at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046591">
        <property type="entry name" value="DUF6649"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20354">
        <property type="entry name" value="DUF6649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="367" mass="39925" checksum="E830464F73CF2054" modified="2006-03-21" version="1">MTQSLKRRPIAAGATQASRPAQPRPRGLSATHPTSRPSPLAISAVPVFSPLAAGGPVVRAIGLETVDGEEWQREGKKVELLAIVNPAGRGPLKMDGVGIDQFHHQHLKKGPFSAQQLPLHPPRKRKAETAPENNERLSKRLSLLNLGMLRPVLSQRPPSIPPQPHQPVNTAPEQSGQKLYVPVENPISQSSQQPTTASPKKHHSRKPPAADDTQMQLDDTKHKVYIYNLDDELSSSDNDSDHESKLVFLPDIEKHLRSSRIPSHVLDPRPGGGGGGGGKELVLYRVPSSLTVPEEQDSVRKAIIEARERAREKQRVEREQRDAPGVMVPEVMASSPSSSSSVGGGVPMDTELLPVLEEDDPDAMELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG66</accession>
    <name>Q2HG66_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220009.1">
        <property type="nucleotide sequence ID" value="XM_001220008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG66"/>
    <dbReference type="GeneID" id="4386887"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00788"/>
    <dbReference type="eggNOG" id="ENOG502QPI7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010671_2_1_1"/>
    <dbReference type="InParanoid" id="Q2HG66"/>
    <dbReference type="OMA" id="IPMSTIA"/>
    <dbReference type="OrthoDB" id="20669at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF12">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="545"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ92553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="721" mass="79230" checksum="FEC9E8561D41711D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG88</accession>
    <name>Q2HG88_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dynamin GTPase</fullName>
            <ecNumber evidence="2">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_00766</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="2"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219987.1">
        <property type="nucleotide sequence ID" value="XM_001219986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG88"/>
    <dbReference type="FunCoup" id="Q2HG88">
        <property type="interactions" value="1205"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HG88"/>
    <dbReference type="GeneID" id="4386871"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00766"/>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008964_5_0_1"/>
    <dbReference type="InParanoid" id="Q2HG88"/>
    <dbReference type="OMA" id="KICHNCG"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034643">
        <property type="term" value="P:establishment of mitochondrion localization, microtubule-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015886">
        <property type="term" value="P:heme transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097753">
        <property type="term" value="P:membrane bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090149">
        <property type="term" value="P:mitochondrial membrane fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140572">
        <property type="term" value="P:vacuole fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000002">
        <property type="entry name" value="Dynamin-1-like protein isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000022">
        <property type="entry name" value="Dynamin-like GTPase Dnm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001027">
        <property type="entry name" value="dynamin-related protein 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF235">
        <property type="entry name" value="DYNAMIN-RELATED PROTEIN DNM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="14">
        <location>
            <begin position="27"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="13">
        <location>
            <begin position="702"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="526"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="632"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="526"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="632"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ92531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="789" mass="87134" checksum="D54BFFE4295BA56C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG93</accession>
    <name>Q2HG93_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219982.1">
        <property type="nucleotide sequence ID" value="XM_001219981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG93"/>
    <dbReference type="FunCoup" id="Q2HG93">
        <property type="interactions" value="1003"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HG93"/>
    <dbReference type="GeneID" id="4386729"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00761"/>
    <dbReference type="eggNOG" id="KOG1769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148322_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HG93"/>
    <dbReference type="OMA" id="MKIYCAR"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16116">
        <property type="entry name" value="Ubl_Smt3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000155">
        <property type="entry name" value="Ubiquitin-like protein SMT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="22"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="99" mass="10439" checksum="47129DAA5F16491C" modified="2006-03-21" version="1">MGGGNSGGGGAGAAAAAAAANEHLNIKVTDNNNEVFFKIKRSTKLEKLMTAFCERQGKTPASVRFLFEGQRVQPADTPDTLEMQDGDTLEVHQEQVGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGC0</accession>
    <name>Q2HGC0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_00734</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219955.1">
        <property type="nucleotide sequence ID" value="XM_001219954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGC0"/>
    <dbReference type="STRING" id="306901.Q2HGC0"/>
    <dbReference type="GeneID" id="4386770"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00734"/>
    <dbReference type="eggNOG" id="KOG2909">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1366094_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGC0"/>
    <dbReference type="OMA" id="SEGFIAW"/>
    <dbReference type="OrthoDB" id="6605928at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.10">
        <property type="entry name" value="subunit c (vma5p) of the yeast v-atpase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ92499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="200" mass="23190" checksum="9393055513BB9464" modified="2006-03-21" version="1">MVNDKLQNIDNDVKAKFNQYNGIKTTLAALQRKQTGNLATKSLTPIVNPNLLVQDSEYLETHLIVVPTNARKDFLRSYETLAPMVVPRSSVQVAQDDEFTLFAVTTFKKTSAEFLQKCREQKWTPRQYKYVEGGKEEEQRELDRIAREEKKVWGEALRLGRTGWSETAMILTHVMTLRVFVETVLRYGLPLERPRSKQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGM2</accession>
    <name>Q2HGM2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_00632</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219853.1">
        <property type="nucleotide sequence ID" value="XM_001219852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGM2"/>
    <dbReference type="FunCoup" id="Q2HGM2">
        <property type="interactions" value="542"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HGM2"/>
    <dbReference type="GeneID" id="4387133"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00632"/>
    <dbReference type="eggNOG" id="KOG1414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034316_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HGM2"/>
    <dbReference type="OMA" id="HGAFMSQ"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000053">
        <property type="entry name" value="BZIP transcription factor AtfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021755">
        <property type="entry name" value="TF_Aft1_HRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021756">
        <property type="entry name" value="TF_Aft1_HRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020956">
        <property type="entry name" value="TF_Aft1_OSM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11786">
        <property type="entry name" value="Aft1_HRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11787">
        <property type="entry name" value="Aft1_HRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11785">
        <property type="entry name" value="Aft1_OSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="421"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="151"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="210"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="446"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="319"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ92397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="538" mass="56768" checksum="383F47837EE5254E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGR3</accession>
    <name>Q2HGR3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219812.1">
        <property type="nucleotide sequence ID" value="XM_001219811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGR3"/>
    <dbReference type="GeneID" id="4387164"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00591"/>
    <dbReference type="HOGENOM" id="CLU_1927349_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGR3"/>
    <dbReference type="OrthoDB" id="10505674at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="131" mass="13850" checksum="0297C35E5170EBDE" modified="2006-03-21" version="1">MEPLTFGLRVSASQWGLWGFGAGASQKQAKRDHGAPNAKLGTAHGGLSAWQSRCPQKLPGSGRAVLKNWSHFQFSYPLFQAPRGLTCPPPIGGQGDGGGGHKSSKGRRDNAISLCDGSNRDGPQWLAMLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGS5</accession>
    <name>Q2HGS5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219800.1">
        <property type="nucleotide sequence ID" value="XM_001219799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGS5"/>
    <dbReference type="STRING" id="306901.Q2HGS5"/>
    <dbReference type="GeneID" id="4387309"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00579"/>
    <dbReference type="eggNOG" id="ENOG502SKU0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054245_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGS5"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="91"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ92344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="179" mass="19333" checksum="45AE8FCC953D2E39" modified="2006-03-21" version="1">MNSQFRGGNSGGPRMSDTVGVGSEDFDDRLGMFLPKKVRARAVSCFADMLRKPGSMRAPSRPSSSRRGETDFLLTGARDEASEEDNLRRTQEPKIFDGLVIYVNGSTHPLVSDIKLKRLVSEHGARMSLHLGRRQVTHVILGKPSGPNGGAGGGLAGGKLEREIRRVGGCGIKFVGVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGT9</accession>
    <name>Q2HGT9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219786.1">
        <property type="nucleotide sequence ID" value="XM_001219785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGT9"/>
    <dbReference type="STRING" id="306901.Q2HGT9"/>
    <dbReference type="GeneID" id="4387128"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00565"/>
    <dbReference type="eggNOG" id="ENOG502S69X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_501517_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGT9"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="543" mass="59851" checksum="BACCE6DB92E11879" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH04</accession>
    <name>Q2HH04_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219721.1">
        <property type="nucleotide sequence ID" value="XM_001219720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH04"/>
    <dbReference type="GeneID" id="4387925"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00500"/>
    <dbReference type="HOGENOM" id="CLU_2133220_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HH04"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="113" mass="12091" checksum="E35CC3B9475E2DEB" modified="2006-03-21" version="1">MANLGRRAMAMIPIPFSCFISRILDNQPPPGVNGSKGDHRSGRYCPGPYGGEPRTMTMAAHPQLPPSQSTSSPTAINHSTLKKRSAGQWTKEPVAGTSQTMAKRIEKLATSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH12</accession>
    <name>Q2HH12_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219713.1">
        <property type="nucleotide sequence ID" value="XM_001219712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH12"/>
    <dbReference type="STRING" id="306901.Q2HH12"/>
    <dbReference type="GeneID" id="4387851"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00492"/>
    <dbReference type="eggNOG" id="ENOG502S090">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039475_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HH12"/>
    <dbReference type="OMA" id="LWVHQLQ"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000051">
        <property type="entry name" value="Glutathione S-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF263">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="17"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="105"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ92257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="28969" checksum="F1A977AAEF87AE90" modified="2006-03-21" version="1">MESETPAKRQRSAKDVPYKLVYWPGIPGRGEHIRLALEEAGADYSDTEGGVDEVLASIQDSGDEFNPPVLAPPVLKHGELTISQTPNILLYLGPRLGLVPDANQNPDGIYRVNSLALTALDGLSNEPHDCHHPIATGLYYEDQKVESKRKSEDYVKNRLPKFLSYFERVLGSKSSGDGPWLYGGSLTYADLVLFHCVDGVKFMFPKAMAKLEQGGKHTKVFALHQAVGERPRIAAYLKSSRRQKYSDGIYRYYEALDIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH18</accession>
    <name>Q2HH18_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_00486</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219707.1">
        <property type="nucleotide sequence ID" value="XM_001219706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH18"/>
    <dbReference type="GeneID" id="4388246"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00486"/>
    <dbReference type="eggNOG" id="ENOG502S7C8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1180092_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HH18"/>
    <dbReference type="OMA" id="THQEDQQ"/>
    <dbReference type="OrthoDB" id="4833365at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="3">
        <location>
            <begin position="178"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ92251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="235" mass="26808" checksum="0DF98919E093125D" modified="2006-03-21" version="1">MTDCAPIGKRLFLRRYAQAKNDAIKERNIRSGWKASGLWPVNLDKPPDEPSTVEPNQPVSQSASQSVSQSVSRRLIKTPNRSQEVHRLISTNVRLRRLQTIDPVARSLFKKVGKSLDNTAIKVASQEQKIRALEAEVDRLRPRKRKKVRMDPNTRFAQIEQIMQAKKALAKQLELSEKLPRTLEALRSGQIKSIRKAAAAFDVPNRILQERVKGVLHVNKRKSRVESYSRPKNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH82</accession>
    <name>Q2HH82_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Centrosomin N-terminal motif 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_00422</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219643.1">
        <property type="nucleotide sequence ID" value="XM_001219642.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HH82"/>
    <dbReference type="GeneID" id="4387184"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00422"/>
    <dbReference type="eggNOG" id="ENOG502R0AV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002168_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HH82"/>
    <dbReference type="OMA" id="FIAVYQH"/>
    <dbReference type="OrthoDB" id="10255000at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019528">
        <property type="entry name" value="PACT_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10495">
        <property type="entry name" value="PACT_coil_coil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="8">
        <location>
            <begin position="177"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Pericentrin/AKAP-450 centrosomal targeting" evidence="9">
        <location>
            <begin position="1278"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="624"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1031"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1138"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1183"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1344"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="228"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1346"/>
            <end position="1363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ92187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1454" mass="165908" checksum="5F01BC3C5C22BB91" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HIE1</accession>
    <name>Q2HIE1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_00013</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219234.1">
        <property type="nucleotide sequence ID" value="XM_001219233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HIE1"/>
    <dbReference type="STRING" id="306901.Q2HIE1"/>
    <dbReference type="GeneID" id="4388264"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00013"/>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_2_1_1"/>
    <dbReference type="InParanoid" id="Q2HIE1"/>
    <dbReference type="OMA" id="AKHIDYG"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="50"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ91778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="247" mass="26701" checksum="26F60F828BFE9492" modified="2006-03-21" version="1">MFDKWVAWSEPSGDLRGAGVEVLEGDVENGFRGTGRMDKIEKLLSPLAKVPLLRVPPYPVVFTKPADALAGPFDDVSIHPDAQNMLDYEGEMTVVIGRDAKNVTEADALSYVLGYTVGNDVSARNFQLPDTSGGQFCYAKSFDGFAPIGPCIVPPSLVPDPQELRLETRVNGAVRQRTGTDDMIFSVAKIIAHLSRGTTLRKGTIIQTGTPSGVGLFMEPKGFLQNGDVVEVSIEGIGKIRNKMVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM72</accession>
    <name>Q2GM72_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_10932</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226199.1">
        <property type="nucleotide sequence ID" value="XM_001226198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GM72"/>
    <dbReference type="STRING" id="306901.Q2GM72"/>
    <dbReference type="GeneID" id="4397194"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10932"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="InParanoid" id="Q2GM72"/>
    <dbReference type="OMA" id="ISIMSIM"/>
    <dbReference type="OrthoDB" id="942095at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000434">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ83114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="368" mass="42167" checksum="293FA2D3F419039A" modified="2006-03-21" version="1">MQSTKVKAEALGRKAKVVLKSANKDDSNLAREIHHHRQFVHPHIARLYEVIVTESLVWLVLEYCSVQKTFTQLVGAVCYVHRQSCVHRDLKLENILLDKHENVKLCDFGFTREYEGKANYLQTFCGTICYSAPEMLKGEKYAGEKVDVWSLGVILYALLTGELPFDDDDDNITRTKILNHEPNYPDHIPPDALSLLKSLLSKRPILRPSLPDILAHSFLAEHAPQQQEILKLERPEPFSTPLEKETLHRMRSAGVDIDSVVDSVLAQKCNVLAGWWTLLIEKEERKQKRRERKRKERELENRTSRRFSQASSRLNALATVEESFVKLSDAPLPRTRGSLARLKISPNRQAEGEGRRLGCRGLIVHLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM74</accession>
    <name>Q2GM74_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226197.1">
        <property type="nucleotide sequence ID" value="XM_001226196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GM74"/>
    <dbReference type="STRING" id="306901.Q2GM74"/>
    <dbReference type="GeneID" id="4397192"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10930"/>
    <dbReference type="eggNOG" id="ENOG502SN8S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021768_5_0_1"/>
    <dbReference type="InParanoid" id="Q2GM74"/>
    <dbReference type="OMA" id="HENIEDW"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="32911" checksum="ADAB785D903E1F30" modified="2006-03-21" version="1">MPETPRKSLDESREDDDSPTNPASSLTTLLHTTSTLLSCMRHPTPPPAANSTTSSAGVSRFVTGRVLEHTTADGAILAIKVNTVTDRSEPAMMHYAATHGVRTPRVRGVYDVVAHTRRLARAMVSERVPGVPLAEVWLGMGEVEREVVKEQLRGQLVAMRACREGFIGGVGGEKVRNVYDRMRDLYCGPFEGEEAFDEWCLGRILGGPLVRAKWRLLLRNERRERRGAGVGGNVVTGIVDWERSGFFPEYAEYAFAMVLCHAHEEWWIPVLKELLPPCSKRRLEFTALVEEGVVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GML9</accession>
    <name>Q2GML9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Inositol oxygenase</fullName>
            <ecNumber evidence="4 14">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 14">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_10785</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="13 14">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4 14"/>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ82967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226052.1">
        <property type="nucleotide sequence ID" value="XM_001226051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GML9"/>
    <dbReference type="STRING" id="306901.Q2GML9"/>
    <dbReference type="GeneID" id="4397356"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10785"/>
    <dbReference type="eggNOG" id="KOG1573">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050259_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GML9"/>
    <dbReference type="OMA" id="RYNTKYG"/>
    <dbReference type="OrthoDB" id="5151075at2759"/>
    <dbReference type="UniPathway" id="UPA00111">
        <property type="reaction ID" value="UER00527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050113">
        <property type="term" value="F:inositol oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF0">
        <property type="entry name" value="INOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="113"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
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    <sequence length="314" mass="35889" checksum="8EB2A018A53D2B62" modified="2006-03-21" version="1">MAAMVDVRPFHRDGAALEAISDAVDTVNILKHMPTTAEPAFDAASTFDTDKDKSTFRQYADACDRVKHFYAEQHAKQTVAHNLAARAHFHSPSRKRPELGIWEAMEKLNTLVDDSDPDTSLSQIQHLLQSAEAIRRDGKPRWMQLTGLIHDLGKLMLFFEGCCDGQWDVVGDTFPVGCRFDERCIYPELFAANPDAGHEVYSTRYGIYQPGCGVNELMMSWGHDEYLYLVLRDQSTLPREALAMVRFHSFYPWHKEGAYTEFMADGDEALLSAVRAFNPYDLYSKSDDVPKVDELKPYYLELIDEFFPQKVIKW</sequence>
</entry>
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                <person name="Untereiner W.A."/>
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</entry>
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                <person name="Untereiner W.A."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN38</accession>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    <dbReference type="eggNOG" id="ENOG502QX51">
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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            <end position="480"/>
        </location>
    </feature>
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        <location>
            <begin position="561"/>
            <end position="684"/>
        </location>
    </feature>
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        <location>
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            <end position="738"/>
        </location>
    </feature>
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            <end position="1054"/>
        </location>
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            <begin position="1083"/>
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        </location>
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        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
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        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
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        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
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        <location>
            <begin position="260"/>
            <end position="319"/>
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        <location>
            <begin position="429"/>
            <end position="444"/>
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        <location>
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            <end position="628"/>
        </location>
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        <location>
            <begin position="648"/>
            <end position="658"/>
        </location>
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            <end position="1037"/>
        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ84212.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1105" mass="121846" checksum="8F4B75175A564440" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN68</accession>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        <location>
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        <location>
            <begin position="1340"/>
            <end position="1349"/>
        </location>
    </feature>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ84182.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1437" mass="160064" checksum="49543D6FAFF178A2" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNC7</accession>
    <name>Q2GNC7_CHAGB</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CHGG_10527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ84123.1"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="4574845at2759"/>
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    </dbReference>
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        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="260" mass="29872" checksum="7B0AB5797739EDFA" modified="2006-03-21" version="1">MAPAQIEYPAWFERIYAKTKEPNPKDFDEDISEFGESEPPEYEFDGDQTDEKYDYYFSFINQREQRKEDLKQMKEGKASQLELEEGKKAKVQAAYEAMAAAEASGEDLTIDPESFYAKMFNLYSPEFVEWTYHHYQLVGANVGFLELRIFDEEEMLVNGNVLLNTYNFSSIEAHGTQSSAGTTEHRIGLSKNEGQPAEEIGMNLKEDTGEWSFGLVIINEDNVLVRLSREFVFRSLSTVEIPADAPEVFEFWGISQDTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNF1</accession>
    <name>Q2GNF1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dedicator of cytokinesis protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_10503</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOCK family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_001228429.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GNF1"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000595_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GNF1"/>
    <dbReference type="OMA" id="LWDNQAF"/>
    <dbReference type="OrthoDB" id="18896at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08679">
        <property type="entry name" value="C2_DOCK180_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11684">
        <property type="entry name" value="DHR2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
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        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="C2_DOCK"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
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    <feature type="chain" id="PRO_5004208414" description="Dedicator of cytokinesis protein 1" evidence="8">
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            <begin position="24"/>
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        <location>
            <begin position="613"/>
            <end position="795"/>
        </location>
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            <begin position="1443"/>
            <end position="1855"/>
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        <location>
            <begin position="103"/>
            <end position="176"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="434"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="446"/>
            <end position="504"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1854"/>
            <end position="2120"/>
        </location>
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        <location>
            <begin position="403"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="485"/>
            <end position="501"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1859"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1920"/>
            <end position="1932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1946"/>
            <end position="1958"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2017"/>
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        </location>
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    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="2033"/>
            <end position="2047"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2064"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS51650"/>
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    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
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        <source>
            <dbReference type="EMBL" id="EAQ84099.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
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    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2120" mass="233871" checksum="604F9B53465434E2" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNM8</accession>
    <name>Q2GNM8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP citrate synthase</fullName>
            <ecNumber evidence="2">2.3.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ATP-citrate (pro-S-)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Citrate cleavage enzyme subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CHGG_10426</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the formation of cytosolic acetyl-CoA, which is mainly used for the biosynthesis of fatty acids and sterols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Composed of two subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
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        <property type="protein sequence ID" value="EAQ84022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_001228352.1"/>
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    <dbReference type="GeneID" id="4396091"/>
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    <dbReference type="eggNOG" id="KOG1254">
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    <dbReference type="HOGENOM" id="CLU_006587_4_1_1"/>
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    <dbReference type="OrthoDB" id="3261737at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:fatty acid biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CCL_ACL-C"/>
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        <property type="entry name" value="ATP-citrate synthase subunit"/>
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    </dbReference>
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        <property type="entry name" value="ATP-citrate synthase subunit 1"/>
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        <property type="entry name" value="Probable ATP-citrate synthase"/>
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        <property type="entry name" value="Citrate Synthase, domain 1"/>
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    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
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        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
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    </dbReference>
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        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
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        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
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        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
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        <property type="entry name" value="Citrate_synthase"/>
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        <property type="entry name" value="Citrate_synthase_sf"/>
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    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
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        <property type="entry name" value="CoA-bd"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
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    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118:SF42">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA-binding" evidence="18">
        <location>
            <begin position="41"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00062455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00076189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAQ84022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="663" mass="72104" checksum="B1DC036B3B2E897E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNQ2</accession>
    <name>Q2GNQ2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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            <begin position="172"/>
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    </feature>
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        <source>
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    </evidence>
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    </evidence>
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</entry>
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    </evidence>
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</entry>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="338" mass="35567" checksum="2F3C3C1521B01D56" modified="2006-03-21" version="1">MAKLRFPDLLAFLTIANLPLAAGSFGGFGGYGDAFTGRIGPFDANSTQFLEAIAASNATAVYKIPGHDVSKPYPGAPIDGWRLHLSALDMSQPPTYQFSDGKPFIGYSMTISAPPALLKANPDGGGKMVDTDPSWGMCMWAYGHPNQLTKERYNNPANKPLAADGSCAGFLSDACIAALEKATEDAYSVAVSATTSRPLRLPRPMQRSGHARRVRRDLQEFWDSQVLNYWVLVTAMVNVTIDPDRESWNPGPGLPSVHCVAPNGQGTGKGFTFSGVVPANALNGDGEEDGGGNVGAGNGGGDEGGNDAGAGNGGDENGARLARNRRPSVPFQIHNHSF</sequence>
</entry>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQF9</accession>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="5355526at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="323" mass="36041" checksum="3CF908DF6E0293E7" modified="2006-03-21" version="1">MCFQLIELYNLCGYLYYQHAVNRCAAYGRRNHEISRRIIRVGYTCSYHEGSDVARGAPAGFASFEDSRRPEPRRRDGNRLTAPGGGSKGDLSAPTLMKPATLPVTSVAETYEEFKRPNATDAPEGGDFKWVPSDSDDSDSYDDSDGESVVSVASTATTIDGDTIGLLFSKLLYFGDLRFLWPQLITVTSEERTLRIRAARFVRKSRANIAQRLCEAHYDFSEQRSAEKDNERLGEQDGGYAPPAEDSDSSPEDDSLFIPEAAEAFLFRTEPILSLQASVKALVRVRAPQTSAFGTGIWKSSKLWFENTMARVWRTELKPENST</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQM2</accession>
    <name>Q2GQM2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227659.1">
        <property type="nucleotide sequence ID" value="XM_001227658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQM2"/>
    <dbReference type="GeneID" id="4396318"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09732"/>
    <dbReference type="eggNOG" id="ENOG502SDT6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_478316_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQM2"/>
    <dbReference type="OMA" id="YLTIDNI"/>
    <dbReference type="OrthoDB" id="4580037at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="542" mass="62041" checksum="CA56D47320FC85FC" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQT9</accession>
    <name>Q2GQT9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_09665</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227592.1">
        <property type="nucleotide sequence ID" value="XM_001227591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQT9"/>
    <dbReference type="FunCoup" id="Q2GQT9">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GQT9"/>
    <dbReference type="GeneID" id="4396760"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09665"/>
    <dbReference type="eggNOG" id="ENOG502QQ16">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013298_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GQT9"/>
    <dbReference type="OrthoDB" id="4484309at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="635"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="766"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="635"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="659"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="683"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ83261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="817" mass="90902" checksum="285F7F212E3F708C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQV6</accession>
    <name>Q2GQV6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227575.1">
        <property type="nucleotide sequence ID" value="XM_001227574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQV6"/>
    <dbReference type="GeneID" id="4396074"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09648"/>
    <dbReference type="HOGENOM" id="CLU_136888_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQV6"/>
    <dbReference type="OMA" id="WCRNIRV"/>
    <dbReference type="OrthoDB" id="4905085at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208924" evidence="1">
        <location>
            <begin position="21"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="121" mass="13553" checksum="4104776F9318A052" modified="2006-03-21" version="1">MKFTTLATAALLALAGTTDAWRVYLHDHSDLGGSSYTASGPGNPGSACHIIPKEHRYRAASITYYAYDRQTNPSTRCKLQLFEGFDCDGMNGPYFSVDTKKALREDWRDRASCFKTTCWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRL5</accession>
    <name>Q2GRL5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227316.1">
        <property type="nucleotide sequence ID" value="XM_001227315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRL5"/>
    <dbReference type="GeneID" id="4395355"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09389"/>
    <dbReference type="HOGENOM" id="CLU_2333443_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRL5"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="98" mass="10971" checksum="B4004F276447C7A1" modified="2006-03-21" version="1">MRPTIDAAGLGRLPYQSGRRLYSPPISGQVREMGYLRVGEAAMEARVLFVCTKLLPPSAVEEAKPSQEDPMEVRRSGKDPDGEREEEGIQVQDNRDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRT5</accession>
    <name>Q2GRT5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227246.1">
        <property type="nucleotide sequence ID" value="XM_001227245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRT5"/>
    <dbReference type="GeneID" id="4395011"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09319"/>
    <dbReference type="eggNOG" id="KOG3798">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2542371_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRT5"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF27">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="83" mass="9719" checksum="9147C7FA8C0A2A09" modified="2006-03-21" version="1">MGSFAGPIRSYPPPCTAEDLPPIDVVCISHNHFDHMDQTSLMSIWRYSRNTVRFFAPLGNKRFLLEWGIPDDRIIELDWWDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GS00</accession>
    <name>Q2GS00_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_09254</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227181.1">
        <property type="nucleotide sequence ID" value="XM_001227180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GS00"/>
    <dbReference type="STRING" id="306901.Q2GS00"/>
    <dbReference type="GeneID" id="4395591"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09254"/>
    <dbReference type="eggNOG" id="KOG0207">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_0_2_1"/>
    <dbReference type="InParanoid" id="Q2GS00"/>
    <dbReference type="OMA" id="DVIRVPH"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000068">
        <property type="entry name" value="Copper resistance-associated P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF32">
        <property type="entry name" value="COPPER RESISTANCE P-TYPE ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="467"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="565"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="597"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="757"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="796"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1145"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1178"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="17"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="205"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="291"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="100"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ85240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1213" mass="130892" checksum="F14A0F9D4018CB3F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GS29</accession>
    <name>Q2GS29_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_09225</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227152.1">
        <property type="nucleotide sequence ID" value="XM_001227151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GS29"/>
    <dbReference type="GeneID" id="4394655"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09225"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001248_0_2_1"/>
    <dbReference type="InParanoid" id="Q2GS29"/>
    <dbReference type="OrthoDB" id="5095382at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF6">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="429"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="916"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="916"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="947"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ85211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="961" mass="106398" checksum="90278227B80CBED4" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GS38</accession>
    <name>Q2GS38_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_09216</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227143.1">
        <property type="nucleotide sequence ID" value="XM_001227142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GS38"/>
    <dbReference type="STRING" id="306901.Q2GS38"/>
    <dbReference type="GeneID" id="4394670"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09216"/>
    <dbReference type="eggNOG" id="ENOG502SAS5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025004_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GS38"/>
    <dbReference type="OMA" id="NGYHSKG"/>
    <dbReference type="OrthoDB" id="5054775at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021711">
        <property type="entry name" value="DUF3295"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053043">
        <property type="entry name" value="Ras-cAMP_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014:SF1">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11702">
        <property type="entry name" value="DUF3295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3295" evidence="3">
        <location>
            <begin position="90"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ85202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="535" mass="58796" checksum="0DDA94824C3C55B2" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GS79</accession>
    <name>Q2GS79_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucanase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_09175</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227102.1">
        <property type="nucleotide sequence ID" value="XM_001227101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GS79"/>
    <dbReference type="STRING" id="306901.Q2GS79"/>
    <dbReference type="GeneID" id="4394990"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09175"/>
    <dbReference type="eggNOG" id="ENOG502QPHV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104719_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GS79"/>
    <dbReference type="OMA" id="IACASNC"/>
    <dbReference type="OrthoDB" id="412382at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208395" description="Glucanase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ85161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="234" mass="24925" checksum="8F0DE659075D35F4" modified="2006-03-21" version="1">MLSKVLALAALLGPAAAQVVGTETTETHPKMTWQKCSAGGSCTNVNGEVTIDSNWRWVHDKNGYTNCYSGNAWNSTICKDDKSCASNCALDGADYPGTYGASTSGNALTLKFVTEGDYSTNIGSRLYLMAGADKYQMFTLLGNEFTFDVDTSKLGCGLNGALYFVSMDEDGGKSKYSGNKAGAKYGTGYCDAQCPRDLKFINGEANVAGWKESSNDQNAGVGQYGSCCTEMDIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSI2</accession>
    <name>Q2GSI2_CHAGB</name>
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        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
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        <name evidence="10" type="ORF">CHGG_09072</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_1_1"/>
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    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00067">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
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    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="532"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="456"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
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        </ligandPart>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ85058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="61781" checksum="5D9A5B1B3F63F029" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSP1</accession>
    <name>Q2GSP1_CHAGB</name>
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        <recommendedName>
            <fullName evidence="4">Sterol regulatory element-binding protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_09013</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSP1"/>
    <dbReference type="STRING" id="306901.Q2GSP1"/>
    <dbReference type="GeneID" id="4394999"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09013"/>
    <dbReference type="eggNOG" id="KOG2588">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008057_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GSP1"/>
    <dbReference type="OMA" id="RVKTWDI"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019006">
        <property type="entry name" value="Sre1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09427">
        <property type="entry name" value="DUF2014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Sterol regulatory element-binding protein 1 C-terminal" evidence="4">
        <location>
            <begin position="513"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ84999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="980" mass="104662" checksum="6E000324895652C0" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GT74</accession>
    <name>Q2GT74_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08830</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226757.1">
        <property type="nucleotide sequence ID" value="XM_001226756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GT74"/>
    <dbReference type="GeneID" id="4394750"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08830"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083410_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GT74"/>
    <dbReference type="OMA" id="LGAHYWR"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="26068" checksum="7C105EC6C2E8AC06" modified="2006-03-21" version="1">MLLAKTIVATGASSGMGFELLKHLLTANPSPTAQPYRIIMGARDVPRTLAAFDTLHYDTARHSVTVLPLELFDLAGTREFARESLKRLAAQHYLLHLFRDKLVESKSRVIIVSSGAVSLTLTMTAESLEKDLRADTVIDLYTTYCQTKFIQLVSAHWWRRELAGKATVVAVSPGFIPGTNLVKKSGLFSEDMPGAQSIAEGRYLELALQEKWSPSKEAIEKEAGLSDWAEAPIPQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTC6</accession>
    <name>Q2GTC6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_08778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226705.1">
        <property type="nucleotide sequence ID" value="XM_001226704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTC6"/>
    <dbReference type="GeneID" id="4395729"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08778"/>
    <dbReference type="HOGENOM" id="CLU_1343094_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTC6"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="204" mass="23646" checksum="119C3DCECD2C757B" modified="2006-03-21" version="1">MVEFMMVEFMMVEFMMVESMMVESMMVESMMVESTYYCILPRADVTDKGAVGSMLHFWPSEPANFGSRTTSPAETAHKEIKSEIINGNSKIEQLELTVQRMVNRTKKRFEDESAKQRSAVAFEFLNKTWLGDIPKQVSYNAHSLIRKRYQMALPAVPTPARPFPPTLRLCTGRHRIQYGLPCSHEIRNALEEQKVLRKEDCHRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTM0</accession>
    <name>Q2GTM0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226611.1">
        <property type="nucleotide sequence ID" value="XM_001226610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTM0"/>
    <dbReference type="GeneID" id="4395154"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08684"/>
    <dbReference type="HOGENOM" id="CLU_1384007_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTM0"/>
    <dbReference type="OrthoDB" id="10429141at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="197" mass="21960" checksum="0F3E56736BE3F8E7" modified="2006-03-21" version="1">MAMAWPTRAVVHLRQATQGSGAAMRISTGVGGGSVNRQRAASDRWMRRSPRKPEFDEPTPGVTLILPHKRRQYLPNGEEHQRIRFSNTPCPASGQWGSGNVLPSLPHCSALQLAASDNGTASCPREVDRRILNRGRLDKSGRRVADAGWWRETLDNDDDKRESRQTFMIRTFMKGVFQLKHRQPPPTGQTKHAGNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTM4</accession>
    <name>Q2GTM4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226607.1">
        <property type="nucleotide sequence ID" value="XM_001226606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTM4"/>
    <dbReference type="GeneID" id="4395150"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08680"/>
    <dbReference type="eggNOG" id="ENOG502SRFI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116365_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTM4"/>
    <dbReference type="OrthoDB" id="5383057at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="204" mass="20612" checksum="5DB5E00C6EB1B980" modified="2006-03-21" version="1">MTYKKVTTCEHVATTRKAPGTVPAGSLAAESVHKGGAFASNPGQHEQAPQKRSQQPQAAQSASRSGGGGTTDKTTLLNLENQQTARGIHTNTGKTTSETGGHSSGSSSLPNQQSYGGAAPSYLAGQQRRDPAGPHGRNLREGGFEGRGTGAGPLPEPGSAQDPARAAVRGVTAAAVSGGGRIPRRAGGFAGMGIRFGDAEVVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU45</accession>
    <name>Q2GU45_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Cellulase</fullName>
            <ecNumber evidence="3 10">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_08509</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 45 (cellulase K) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3 10"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226436.1">
        <property type="nucleotide sequence ID" value="XM_001226435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GU45"/>
    <dbReference type="SMR" id="Q2GU45"/>
    <dbReference type="GeneID" id="4395115"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08509"/>
    <dbReference type="eggNOG" id="ENOG502RXA6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045022_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GU45"/>
    <dbReference type="OMA" id="NYSPWAV"/>
    <dbReference type="OrthoDB" id="10035502at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22278">
        <property type="entry name" value="DPBB_GH45_endoglucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052288">
        <property type="entry name" value="GH45_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000334">
        <property type="entry name" value="Glyco_hydro_45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39730">
        <property type="entry name" value="ENDOGLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39730:SF1">
        <property type="entry name" value="ENDOGLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02015">
        <property type="entry name" value="Glyco_hydro_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01140">
        <property type="entry name" value="GLYCOSYL_HYDROL_F45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208612" description="Cellulase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="13">
        <location>
            <begin position="272"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="206"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ84495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="308" mass="31962" checksum="82EFEE14060B4CB3" modified="2006-03-21" version="1">MRSTPILRTALAAALPLVAYAADGKSTRYWDCCKPSCSWPGKALVNQPVYACSANFQRITDSNAKSGCDGGSAFSCADQTPWALNDDFAYGFAATSLAGGSEASWCCSCYELTFTSGPVAGKKMVVQSTSTGGDLGSNHFDLNIPGGGVGIFDGCSPQFGGLGGQRYGGVSSRSECDAFPEALKPGCYWRFDWFKNADNPNFTFRQVQSLPKPSSSSSPVAVPKPTSTPGSVPKPTSTPGSAPEPATPTSAVPSVKTSASASPSKSSSPVSCVTEKYGQCGGNGFTGCKTCTCGTTCKKQNDWYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUF9</accession>
    <name>Q2GUF9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_08395</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226322.1">
        <property type="nucleotide sequence ID" value="XM_001226321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUF9"/>
    <dbReference type="GeneID" id="4394690"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08395"/>
    <dbReference type="eggNOG" id="KOG1153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_1_4_1"/>
    <dbReference type="InParanoid" id="Q2GUF9"/>
    <dbReference type="OMA" id="DWITANH"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012565209" evidence="8">
        <location>
            <begin position="16"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="10">
        <location>
            <begin position="31"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="145"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ84381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="348" mass="35543" checksum="4C31A2EDBCA4F486" modified="2006-03-21" version="1">MQLLTLATLLPLALAAPVIQPRGVQLIPGNYIVKLKAGASESTLQDAIRHVKTGSTKHIYRAGRFKGFAAQLSPQVLDTVSKLSEVEYVEQDAIITTQESVTQTDNVPWGLARISHRATGATSYVYDESAGEGTCSYIIDTGIYVAHTTKLFAVKVLDANGSGTISSVLAGIDFVASDAAARSAAGECPNGSVANMSLGGGKSTAINSAAAAAVSSGVFFAVAAGNSNDDAKYYSPASEPTVCTVGATDVADARAYFSNYGAGVDVFAPGVDVLSSWIGGVDETNTISGTSMASPHVAGLGAYLLGLLGPKTPAELCQHLKDTATVGSITGLPSGTVNALVYNGNAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV61</accession>
    <name>Q2GV61_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_08143</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225799.1">
        <property type="nucleotide sequence ID" value="XM_001225798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV61"/>
    <dbReference type="STRING" id="306901.Q2GV61"/>
    <dbReference type="GeneID" id="4394157"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08143"/>
    <dbReference type="eggNOG" id="ENOG502SNSW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_372537_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GV61"/>
    <dbReference type="OrthoDB" id="2943660at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045122">
        <property type="term" value="P:aflatoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013700">
        <property type="entry name" value="AflR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08493">
        <property type="entry name" value="AflR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209055" description="Zn(2)-C6 fungal-type domain-containing protein" evidence="7">
        <location>
            <begin position="26"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="341"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="201"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="375"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="727"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="464"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ86890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="746" mass="78335" checksum="0F835D990161E0F4" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWR1</accession>
    <name>Q2GWR1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CHGG_07593</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225249.1">
        <property type="nucleotide sequence ID" value="XM_001225248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWR1"/>
    <dbReference type="STRING" id="306901.Q2GWR1"/>
    <dbReference type="GeneID" id="4393733"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07593"/>
    <dbReference type="eggNOG" id="ENOG502RY3D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031730_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GWR1"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF36">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208525" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="17">
        <location>
            <begin position="20"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="18">
        <location>
            <begin position="313"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="262"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAQ86340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="349" mass="35643" checksum="678D1CC10B226B64" modified="2006-03-21" version="1">MSKASALLATLTGAALVAAHGHVSHIIVNGVYYENYDPTTHWYQPNPPTVIGWKAAQQDNGFVEPNNFGTSDIICHKSGSPGGGHATVAAGDKISIVWDPEWPESHIGPVIDYLAACNGDCETVDKASLRFFKIDGAGYDKTAGRWAADTLRANGNSWLVQIPADLKAGNYVLRHEIIALHGASSPNGAQAYPQCINLRVTGSGTNAPSGVAGTSLYRASDAGILFNPYVASPNYPVPGPALIAGAASSVAQSKSVATATASATLPGNNNGGGPNPQPTTATTTANPGVSTTLRTSTSTSTSAQVTPPPTGGNAQTKYGQCGGSGWTGPTACAAGSSCSVLNDWYAQCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWV8</accession>
    <name>Q2GWV8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_07546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225202.1">
        <property type="nucleotide sequence ID" value="XM_001225201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWV8"/>
    <dbReference type="GeneID" id="4393290"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07546"/>
    <dbReference type="eggNOG" id="ENOG502SHRF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_533158_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWV8"/>
    <dbReference type="OMA" id="NYAMARC"/>
    <dbReference type="OrthoDB" id="5419927at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619:SF3">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ86293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="511" mass="56780" checksum="FACB6924D081E475" modified="2006-03-21" version="1">MAQRTQEDAGDMGPWITFNAPEHDPAWAFKQAMDKLEQRKDHFRQFMKRFLAKYNDRGAWKVTFDESTTWPQVLEEATQAFDDYTKRGRSWRHPFRSTQRLFGSVACRIKFLVVLLPDGDFTGALCGGLCLIYNAATRRREIQELIIRTLDSLSQHVEGTKSFLMMYAWDEDVRQKTEDLYIAILETIEALTEWLYRSSLHAVHHNVLTVGKRVEQMSEHITALRFEALSVLEKQFHGMSKGVEWQIHRLEERQRNFHLQTLQAIPHPNTTTTFLNPYLPPTPPQPTLTIPSLLTPLNLPTNPTTTPPNTTTTNTINTPYPLTKDQNLTLLLSRATQQQQQSTLHFATASHQFQTWLRSLSSCVLTIHGMDVTPPTSSMAPGVLGGVVVPVTIHFCALLLGGLARLADGDGGGGVYPVGFYCRLHGGGGHGGGGGGGSEEGFDGPAGMMRFLIAQVVLLLATRRAELGVDLSHVGVAEAEALRRRDLDALCLVFDGLVKQIGVGVVFGPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX77</accession>
    <name>Q2GX77_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_07427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225083.1">
        <property type="nucleotide sequence ID" value="XM_001225082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX77"/>
    <dbReference type="GeneID" id="4394046"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07427"/>
    <dbReference type="HOGENOM" id="CLU_2621813_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GX77"/>
    <dbReference type="OrthoDB" id="10442430at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ86174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="78" mass="8484" checksum="0E10D7203DE993D1" modified="2006-03-21" version="1">MNDNEDASRMMDHLLFGIDRRVGSVLIYAIEGPEITLSAPESGLTTIFRLGNPEPRECLESSVFSSLPCVVARAGSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX85</accession>
    <name>Q2GX85_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spherulin-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_07419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225075.1">
        <property type="nucleotide sequence ID" value="XM_001225074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX85"/>
    <dbReference type="GeneID" id="4394022"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07419"/>
    <dbReference type="eggNOG" id="ENOG502T62S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060605_3_0_1"/>
    <dbReference type="InParanoid" id="Q2GX85"/>
    <dbReference type="OMA" id="HSFYIAQ"/>
    <dbReference type="OrthoDB" id="5342184at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040:SF9">
        <property type="entry name" value="4-LIKE CELL SURFACE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ86166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="32819" checksum="5270E4E82972A766" modified="2006-03-21" version="1">MKPTLLTTLAATATATEILLPLYQFPASNGGVWAPIERALTANPSLTAKIIINPNNGPGGPNQGIDDPQYEAGTKSLAAHANAQLLGYVHTSTDLGATRCNVPWADITADIRKWATWVDRGVAIRGIFIDEAPNSSANDCVAYMRNLTELIRTDEELVARFGPRPVVVYNPGGTGALQPFYDLGPDLIVALETCFTVPELAGEDYDQCPKAGGYERYDHDGVGSSIDNVLFPSVGAANAAQTAVLVHGFHDFNGPSANLSATAAVLEQLVGAVVQRGIGATFFNTRGYHAFEDEPATFEAFAGVLNAANAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXL5</accession>
    <name>Q2GXL5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Elongation factor 1-gamma 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_07289</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224945.1">
        <property type="nucleotide sequence ID" value="XM_001224944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXL5"/>
    <dbReference type="FunCoup" id="Q2GXL5">
        <property type="interactions" value="1111"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GXL5"/>
    <dbReference type="GeneID" id="4394269"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07289"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_3_0_1"/>
    <dbReference type="InParanoid" id="Q2GXL5"/>
    <dbReference type="OMA" id="TQYFSWT"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000006">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000142">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1010:FF:000001">
        <property type="entry name" value="Elongation factor 1-gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1010">
        <property type="entry name" value="Translation elongation factor EF1B, gamma chain, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001662">
        <property type="entry name" value="EF1B_G_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036433">
        <property type="entry name" value="EF1B_G_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00647">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01183">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89942">
        <property type="entry name" value="eEF1-gamma domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50040">
        <property type="entry name" value="EF1G_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="80"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="EF-1-gamma C-terminal" evidence="6">
        <location>
            <begin position="246"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="210"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ86036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="45829" checksum="D94CCA7B9A6F9498" modified="2006-03-21" version="1">MAFGQLYTYAGNPRSTGIRAVAKANNLELEEVDTDTTQPSAEFLKLNPLHKVPTFVGADGFVLTECIAIAVYGTPQAANNPGSYASILRWMSYFNSEVLPKLGGWFRPLLGKDPYNKKAVEESQKAALAVISVVEAHLRDNTYLVGERITLADVFAAGLISRGFEYFFDKEWRQQNPNVSRWYETVYKQPIYSAVVPELSLLDTPKLTNVAPKKPEQAKPAKQAPKPAAAAKPQDEEEAPAEAPKPKHPLELLPKASLPLDEWKRQYSNSETPDAMKWFWENVNFEEYSIWKCTYKYNDELTLTFMSSNLIGGFNTRLEASRKYVFGCASVYGVNNDSVIEGAFVIRGQEFEPVFDVAPDYESYEFTKLDPTKPEDREYVELQWTWEKPVVVNGKEYPHAAGKVFK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-19" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXY3</accession>
    <name>DXO_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Decapping nuclease RAI1</fullName>
            <ecNumber evidence="5">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD-capped RNA hydrolase RAI1</fullName>
            <shortName evidence="7">DeNADding enzyme RAI1</shortName>
            <ecNumber evidence="1">3.6.1.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RAI1</name>
        <name type="ORF">CHGG_07171</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2 4 5">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA (By similarity). The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (By similarity). Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs (By similarity). Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1) (By similarity). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates (By similarity). Stimulates exoribonuclease activity of Rat1, allowing it to degrade RNAs with stable secondary structure more effectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="5">Divalent metal cation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with RAT1; the interaction is direct, stabilizes RAT1 protein structure and stimulates its exoribonuclease activity (By similarity). The interaction also stimulates RAI1 pyrophosphohydrolase activity, probably by recruiting it to mRNA substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="5 1"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224827.1">
        <property type="nucleotide sequence ID" value="XM_001224826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXY3"/>
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        <property type="interactions" value="562"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GXY3"/>
    <dbReference type="GeneID" id="4393258"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07171"/>
    <dbReference type="eggNOG" id="KOG1982">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024877_4_1_1"/>
    <dbReference type="InParanoid" id="Q2GXY3"/>
    <dbReference type="OMA" id="VVTWRGH"/>
    <dbReference type="OrthoDB" id="5853397at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110152">
        <property type="term" value="F:RNA NAD+-cap (NAD+-forming) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000249830" description="Decapping nuclease RAI1">
        <location>
            <begin position="1"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="340"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O13836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="O70348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P53063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="4">
        <source>
            <dbReference type="UniProtKB" id="Q06349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="5">
        <source>
            <dbReference type="UniProtKB" id="Q5AAT0"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="373" mass="42668" checksum="F94C7048026328AB" modified="2007-01-23" version="3">MTLQFPIQAPARYAGETEPVKRPREFACFSYDKDHKFRLDDSSMKWYYPPEIGTNLSHGYDTFIKHDDSVDEHLDSLLKTIADHEQQTGGPIDAHIVTWRGMLTKVGGSDASFLSLWFEMNATLYRLTFTSGYKFETLSTIPRPWGETTRDYIENRDNEVTNNKEQYCSVVRTGFGKSIVCLGGEVDAIWDAKPETPGKPINWVELKTTAEIHTHNDRFKFDRKLMRYWIQSFLLGVPKIIVGYRTQDGILSGVEEFSTLSMPQDVQRRKTAKWDGNVCIKFASLFLDWLRQSINDGGVWRIRRENKSDHIELFKVEEVGHGSIITDEFMNWRIKLSLNKDKPPGFEPSDAADAEPSMAEEPVPETASASGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXY6</accession>
    <name>Q2GXY6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein sorting-associated protein 68</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_07168</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224824.1">
        <property type="nucleotide sequence ID" value="XM_001224823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXY6"/>
    <dbReference type="FunCoup" id="Q2GXY6">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GXY6"/>
    <dbReference type="GeneID" id="4393255"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07168"/>
    <dbReference type="eggNOG" id="KOG3393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096876_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GXY6"/>
    <dbReference type="OMA" id="VHITFVD"/>
    <dbReference type="OrthoDB" id="268928at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034424">
        <property type="term" value="C:Vps55/Vps68 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ85915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="18551" checksum="9DE387F3BE8B9132" modified="2006-03-21" version="1">MSEDRLWKFRRPEWLNSAWARNAGVYGAGGLFSLAFYTLLDSAVWSKSALNSSTLHVTFVDWLPFLFSSLGMLIINSVEKARLSADSFSYSGSGVAWKARVVLFLGFAALAGGMAGGVTVFVLKFVVPGVAFPAMTMGVENLVANALVGLSSVVLWISQNMEDEYSYNLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GY76</accession>
    <name>Q2GY76_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_07078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224734.1">
        <property type="nucleotide sequence ID" value="XM_001224733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GY76"/>
    <dbReference type="GeneID" id="4393806"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07078"/>
    <dbReference type="eggNOG" id="ENOG502SNB9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_976597_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GY76"/>
    <dbReference type="OrthoDB" id="5404599at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="108"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ85825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="285" mass="32092" checksum="7F1C37EC55DBC316" modified="2006-03-21" version="1">MAHRKQAHSPALSRAARGGLPLGEPRRRVVFHAFRGPSSPACCRPARPWDPDGHDRQIHDAGDVSAVFSFGDEIVIKIRLATDETRREPETLASLAKQQQHLSFDIHTVHFYVEDAGKTYLDRLRQQLDEPTARDAQRQCRGRPTAVRDCEALGMDCSVFVLAHNDLGPTNIIVDGDRIVVVDWQMAGYVPLEWVRTKFASCGVLGVERVRTRGPGGEGPVRVTAERNGEYRVSRCVLREGWRGWDFRRSRRRIRGCMVCAKWNGGQVGRGFNERTASITENIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYK1</accession>
    <name>Q2GYK1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphotyrosine protein phosphatase I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_06953</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224609.1">
        <property type="nucleotide sequence ID" value="XM_001224608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYK1"/>
    <dbReference type="FunCoup" id="Q2GYK1">
        <property type="interactions" value="512"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GYK1"/>
    <dbReference type="GeneID" id="4394460"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06953"/>
    <dbReference type="eggNOG" id="KOG3217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071415_2_2_1"/>
    <dbReference type="InParanoid" id="Q2GYK1"/>
    <dbReference type="OMA" id="VCHGNIC"/>
    <dbReference type="OrthoDB" id="3388at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16343">
        <property type="entry name" value="LMWPTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050438">
        <property type="entry name" value="LMW_PTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717:SF7">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphotyrosine protein phosphatase I" evidence="5">
        <location>
            <begin position="5"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617867-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ85700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="201" mass="21998" checksum="D28CA2B0DD80F130" modified="2006-03-21" version="1">MSDQLSVLFVCLGNICRSTMAEGVFQSLARKEPYSELVGKIDSCGTSAYHVGDGPDERTMATLEDHGITNYVHCARKVDASDFDKFDYIFAMDRGNLADLERIQRRKPSSKAKLMLFGEYSGTGKTEIISDPYYGGVSSTSALWPGSSRACRRRWGAGAIQPRTMPLNSLSPTAIWVAQDRQAAGISAMEQARRSSIPALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZ26</accession>
    <name>Q2GZ26_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224434.1">
        <property type="nucleotide sequence ID" value="XM_001224433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZ26"/>
    <dbReference type="GeneID" id="4391747"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05220"/>
    <dbReference type="eggNOG" id="ENOG502T31G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_489152_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZ26"/>
    <dbReference type="OMA" id="PWAREFE"/>
    <dbReference type="OrthoDB" id="3594103at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050972">
        <property type="entry name" value="SDr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403:SF14">
        <property type="entry name" value="OS05G0225800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="61994" checksum="E4CFC7718DA13C20" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZ43</accession>
    <name>Q2GZ43_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminotransferase class V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_05203</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224417.1">
        <property type="nucleotide sequence ID" value="XM_001224416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZ43"/>
    <dbReference type="STRING" id="306901.Q2GZ43"/>
    <dbReference type="GeneID" id="4391934"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05203"/>
    <dbReference type="eggNOG" id="KOG1549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_3_0_1"/>
    <dbReference type="InParanoid" id="Q2GZ43"/>
    <dbReference type="OMA" id="EFAHHDG"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092:SF2">
        <property type="entry name" value="HERCYNYLCYSTEINE SULFOXIDE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092">
        <property type="entry name" value="L-CYSTEINE DESULFHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="3">
        <location>
            <begin position="113"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ88584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="480" mass="52611" checksum="40DA4C670DE3171B" modified="2006-03-21" version="1">MAPTQVELPLRAKAQADGDASQAESKLSGPVAFGHALRDEQFLFEPSYRNLNHGSFGTIPRPIPNPPSGTTSSLRGIRPRTASIRVRLPHPSSTGSRVRHRPAYVNDPPLRPVVFVSNANLWGVNTVLRNLAWHADGRDEILYFDTLYGGCAKTVDYVVEDRAGKVAGRCIPLGYPCEDAEVVARLVGAVEAAVEEGKRPRVCVFDVVSSLPGVRFPFEAVTAACRERGLLSLIDGAQGVGMVDIDLGKVDPDFFVSNCHKWLHVPRGCAVFYVPLRNQGMIRSTVPTSHGFVSSAGVKRPNPLPPSNKSEFVTAFEFVGTLDNSPYLCVKESIKWREEVLGGEARIRDALTALAREGGKRVAEILGTEVMDNASQSLTRCSMVNVALPLAVQPEDGKALEGELASLPSFPQSDAGTITHWMLRKLLDDHNTFIALYIYGGRWWARLSAQVYLELEDFEWAGETLKSVCERVVKGEYKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZ44</accession>
    <name>Q2GZ44_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_05202</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224416.1">
        <property type="nucleotide sequence ID" value="XM_001224415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZ44"/>
    <dbReference type="GeneID" id="4391933"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05202"/>
    <dbReference type="eggNOG" id="ENOG502QVTZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035433_2_1_1"/>
    <dbReference type="InParanoid" id="Q2GZ44"/>
    <dbReference type="OMA" id="ECIGIRT"/>
    <dbReference type="OrthoDB" id="2365600at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012962">
        <property type="entry name" value="Pept_M54_archaemetzincn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15910">
        <property type="entry name" value="ARCHAEMETZINCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15910:SF1">
        <property type="entry name" value="ARCHAEMETZINCIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="291"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ88583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="366" mass="40407" checksum="FA8D66EED91184A6" modified="2006-03-21" version="1">MPSCQHETLHLDVSPHAAEIGFARPSLAKRKAATTASGRASGNTSDHLLLESLFPGPLVLPDDCLAIDPKEPPQSLRSWTMEKLRNPFTPERKTVYVVPTPNIPSGTAFSRTLNRWTLPFVLQAPLKEGCDAPKAKYIRNYLEAFYHPIPVRTLPNMASFVPWTEGKSKPNPKQPPQYIGLQLGDNVTRITTRPCPDETYPRQLNLNDMLDAAIEALPSDAYALVLLTDHDLYEDDDDDFCCGRAYGNSRVAVVSSARYHPLLDEPTGIDREHTWPFSHCDAYVQRLCRDGEEDHEPGGSASTTSSSSSSSSSSSSNPKRRKLTAPQPSPPQPPQEPQHPHDPRHPGPVSAPPDRTTARRACGWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZB8</accession>
    <name>Q2GZB8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoporin NUP49/NSP49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_05128</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224342.1">
        <property type="nucleotide sequence ID" value="XM_001224341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZB8"/>
    <dbReference type="STRING" id="306901.Q2GZB8"/>
    <dbReference type="GeneID" id="4391721"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05128"/>
    <dbReference type="eggNOG" id="KOG0845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027081_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZB8"/>
    <dbReference type="OMA" id="KLPTHYH"/>
    <dbReference type="OrthoDB" id="2538017at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024882">
        <property type="entry name" value="NUP58/p45/49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437">
        <property type="entry name" value="NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437:SF2">
        <property type="entry name" value="NUCLEOPORIN P58_P45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21121">
        <property type="entry name" value="Nup49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="110"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ88509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="47304" checksum="503880DF08ECFD6A" modified="2006-03-21" version="1">MSLARSASGPGGLSINTGSANLFPQREVDSSARRLPSPPKQPLRSRLDPSSVRQPPRLPLHNLKPADYSGKPRPPPNHSKQEVCLGQQQHNNLSSRRGGSLGGATTSQPAQAGGLFGGTTQTQQPQQQAGGLFGGAATQQQQQQPQAAGGLFGSSTANTGGMFGNKPAATTTGGGLFGQTQSQPQQSQAGGLSLGQSTAQQQTVPGVRIDLSNIKSTTRFNDLQETLQKEIAQIDEAIQRCIKDKDAVDAFLPSHGEQLAAIPTDVGFVTRKSEGAHNALSSDIRAIDQLRELVKTDAGHARLSFKAIDNLKLPTQYHQAGLWANRGQQVGGAGAGGQGGAADAQSNTDLISFFSATAGEMDDMMKKFERNLGEIEVHLHGVQGNMLEQMQRVAAQSKSTTPGGVDQRVVELAAVLRDFEESILKVAGVVGGVKEGVTELQLKDFMGHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZM4</accession>
    <name>Q2GZM4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_05022</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224236.1">
        <property type="nucleotide sequence ID" value="XM_001224235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZM4"/>
    <dbReference type="STRING" id="306901.Q2GZM4"/>
    <dbReference type="GeneID" id="4392797"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05022"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_2_5_1"/>
    <dbReference type="InParanoid" id="Q2GZM4"/>
    <dbReference type="OMA" id="ETTVWRL"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16509">
        <property type="entry name" value="RING-HC_HLTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF11">
        <property type="entry name" value="FAMILY HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G06590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="316"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="599"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="640"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="647"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ88403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="819" mass="90799" checksum="653609D18AB47069" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZT7</accession>
    <name>Q2GZT7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_04959</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224173.1">
        <property type="nucleotide sequence ID" value="XM_001224172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZT7"/>
    <dbReference type="STRING" id="306901.Q2GZT7"/>
    <dbReference type="GeneID" id="4393030"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04959"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_4_1"/>
    <dbReference type="InParanoid" id="Q2GZT7"/>
    <dbReference type="OMA" id="ACHVTNK"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF252">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ88340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="310" mass="33137" checksum="8FFB18E0771EE184" modified="2006-03-21" version="1">MAVLSAIHGISSVILSNLFVTLPLPQAHPDLANQTIIVTGANTGLGLETSRHLLRLGVHKLIMAVRNPEKGAAARDNLLLSTSRPASTIEIWPLDMADPTSILSFTQRAARELPRLDGVLANAGLMTQHFTLTAHHEQTLTVNVLHTFLLCLLLLPTMRASTRETGYPCRFAIPNSGLHYVAPLGELATTPDGESLLQRLDDPARADMAGRYPLSKVLVLWGVRELAARLGGGAENKGKEGGVEVIINTPNPSYCVSSLGKEGDGPGVGMRVAEKLLARTTEEGSRALFHGLVAGVESQGQYLTNCHVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZU2</accession>
    <name>Q2GZU2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycolipid transfer protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224168.1">
        <property type="nucleotide sequence ID" value="XM_001224167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZU2"/>
    <dbReference type="STRING" id="306901.Q2GZU2"/>
    <dbReference type="GeneID" id="4392767"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04954"/>
    <dbReference type="eggNOG" id="KOG3221">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079400_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZU2"/>
    <dbReference type="OMA" id="EMHGAEW"/>
    <dbReference type="OrthoDB" id="205255at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000001">
        <property type="entry name" value="Pleckstrin domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="33"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="206" mass="22853" checksum="3CE1BADE935D81F5" modified="2006-03-21" version="1">MAATQIPEGGTYIDTFKGSFTTVPIDAENANAISTTEFLDASESLTTMFDLLGSVAFSPVKKDVLGNVEKLRKRQLAAPLESQNIQDLVRNELKTKSHTATEGLLWLVRALEFTCIALSQNLAQETTELSDSFRDAYGVTLKPHHSFLVKPVFSAAMSACPYRKDFYVKLGSDQEKVKVELRQYLEALEKVVGILKGFLDTPEAKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H004</accession>
    <name>Q2H004_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_04892</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224106.1">
        <property type="nucleotide sequence ID" value="XM_001224105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H004"/>
    <dbReference type="GeneID" id="4393011"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04892"/>
    <dbReference type="eggNOG" id="ENOG502RPS2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_483953_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H004"/>
    <dbReference type="OrthoDB" id="3145928at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="333"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="403"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ88273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="60014" checksum="67893B40C4993284" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H057</accession>
    <name>Q2H057_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_04839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224053.1">
        <property type="nucleotide sequence ID" value="XM_001224052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H057"/>
    <dbReference type="GeneID" id="4392340"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04839"/>
    <dbReference type="eggNOG" id="ENOG502T5E8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160125_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H057"/>
    <dbReference type="OrthoDB" id="5150811at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ88220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14135" checksum="180DD4B95B0E89AB" modified="2006-03-21" version="1">MVNLAELGAKLTAGRQPGQELSPCARAAIAGAVAAGASQTAVAKAFSTSRRAVQLSLQRFESSTTFETKPRTGRPELLTRREKRYILQLAKRYPRYSLQMLTGTLDTRISRSTSIFTDESSSRITRVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0F4</accession>
    <name>Q2H0F4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">GTP-binding protein SAS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_04742</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Protein transport. Probably involved in vesicular traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223956.1">
        <property type="nucleotide sequence ID" value="XM_001223955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0F4"/>
    <dbReference type="FunCoup" id="Q2H0F4">
        <property type="interactions" value="486"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H0F4"/>
    <dbReference type="GeneID" id="4392223"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04742"/>
    <dbReference type="eggNOG" id="KOG0078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_23_1_1"/>
    <dbReference type="InParanoid" id="Q2H0F4"/>
    <dbReference type="OMA" id="ENIRTWF"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000363">
        <property type="entry name" value="Secretion related GTPase srgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ88123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="22818" checksum="2AEA87A20379FD7D" modified="2006-03-21" version="1">MSSSNRNYDFLIKLLLIGDSGVGKSCCLLRFSEDSFTPSFITTIGIDFKIRTIELDGKRVKLQIWDTAGQERFRTITTAYYRGAMGILLVYDVTDERSFNNIRTWFANVEQHATEGVNKILIGNKCDWEEKRVVSTERGQQLADELNIPFLEVSAKTNNNIDKAFYSLAADIKKRIIDTSKPDQAGSGPAVNVGEQSGAGGGGKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0L9</accession>
    <name>Q2H0L9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Developmental regulator flbA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_04677</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223891.1">
        <property type="nucleotide sequence ID" value="XM_001223890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0L9"/>
    <dbReference type="FunCoup" id="Q2H0L9">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H0L9"/>
    <dbReference type="GeneID" id="4393007"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04677"/>
    <dbReference type="eggNOG" id="KOG3589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013365_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H0L9"/>
    <dbReference type="OMA" id="DPGMRYL"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04450">
        <property type="entry name" value="DEP_RGS7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08708">
        <property type="entry name" value="RGS_FLBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058855">
        <property type="entry name" value="RGS1/SST2-like_Fungal-DR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25889">
        <property type="entry name" value="WHD_Fungal_DR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="DEP" evidence="4">
        <location>
            <begin position="389"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="512"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="482"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="666"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ88058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="687" mass="75859" checksum="E8F3594B715E7500" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H161</accession>
    <name>Q2H161_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_04485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223699.1">
        <property type="nucleotide sequence ID" value="XM_001223698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H161"/>
    <dbReference type="GeneID" id="4391800"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04485"/>
    <dbReference type="eggNOG" id="ENOG502SPBP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024655_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H161"/>
    <dbReference type="OMA" id="ECKQINE"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ87866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="34949" checksum="9A63A2458D5E36C9" modified="2006-03-21" version="1">MQNPGVPAVSLGDWPAAGLGPDLDHIPLQPDTLTPHDLISTTPLFGPLSGRRELSGSETSPWFLQDETWVKEHQQPHGSAGVELDPFIHAVEGMLQSWARTGHNSFIHERLYGKSMPPCLQDAFTTLSAYTSCTPVVKETILQIAEDRSSALACESLPSAAVGGGDGGDGDGGAAAVRGYLARVHALFTYIFIRLFDGSVRARAAAEELWQLWILTESVRRSLIIIETIANVYECMVRGWAECTGAVMFTARAGLWEAKSAVKWLELSSVESPLLASSLCPEQFISRYAAGEIDGFAKVVWGCAVGVDRMQCWIDGTVGESRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1B3</accession>
    <name>Q2H1B3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_04433</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
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                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A2 family.</text>
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        <property type="nucleotide sequence ID" value="XM_001223646.1"/>
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    <dbReference type="STRING" id="306901.Q2H1B3"/>
    <dbReference type="GeneID" id="4392240"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04433"/>
    <dbReference type="eggNOG" id="KOG0227">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_050757_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H1B3"/>
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    <dbReference type="OrthoDB" id="10250970at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Splicing factor 3a subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="11">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ87814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="250" mass="28040" checksum="CAA049251B34CE0F" modified="2006-03-21" version="1">MDYQNRAGSKFGGGGVASHSATNADRRERLRKLALEQIDLDKDPYIFKNHLGSFECRLCLTVHQNDGSYLAHTQGKKHQTNLARRAAREQKEGKGEVDPHTGLPVGVVGAGFAALGLGGAGAGGPRKNVVKIGRPGYKITKVRDPITRQQGLLFQLQYPDIGTGVAPKWQVMSAFSQRVEDPDRNFQYLLVAAEPYETCGFKIPARELDKREDRQFEYWDPDSKEYWVQIMFMTEREERFNAAPGLTGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H289</accession>
    <name>Q2H289_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Palmitoyl-protein thioesterase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_04107</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223321.1">
        <property type="nucleotide sequence ID" value="XM_001223320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H289"/>
    <dbReference type="STRING" id="306901.Q2H289"/>
    <dbReference type="GeneID" id="4391863"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04107"/>
    <dbReference type="eggNOG" id="KOG2541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050129_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H289"/>
    <dbReference type="OMA" id="FRECEPT"/>
    <dbReference type="OrthoDB" id="10263094at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF8">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209209" description="Palmitoyl-protein thioesterase 1" evidence="3">
        <location>
            <begin position="22"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ87488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="31105" checksum="30FBFB2DE7CF518E" modified="2006-03-21" version="1">MAFVGALKLLAVGSLISASVAKPIEPRFQNDNDDTPLPLVIWHGLGDTYQADGIRHVAEIAEEVNPGTLTYLIRMDEDASRDRLVTFGSQHNGISNFRECEPTDWICRIAMAVVKGDAWNSAVQSTLVPAQYYRNPDEYEQYLENSNFLADINNEREEKNEQYKKNIANLENFVMYMFEDDKTVIPKETAWFEDVNGTETTPLRARKLYSEDWLGLRQLDRKGGLKFRLAPGEHMKLTEDILKEAFGDFYGPLNPHRGRSEPRPKHVHNDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3L8</accession>
    <name>Q2H3L8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_06747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222842.1">
        <property type="nucleotide sequence ID" value="XM_001222841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3L8"/>
    <dbReference type="GeneID" id="4390654"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06747"/>
    <dbReference type="HOGENOM" id="CLU_1635180_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3L8"/>
    <dbReference type="OrthoDB" id="10536704at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208883" evidence="2">
        <location>
            <begin position="21"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ90128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="162" mass="16369" checksum="BCA57B10763ADFCA" modified="2006-03-21" version="1">MVYVSALAPALLLSVTGALATTAAASALPTSSSVGNSAADSGPPHILFSEDATTISYANTDTDADTDADTDDTDTDTSTGFEPFDPVQHKGIHRCNRSPLRCDCSKNATELAALNALRHEKNCAKCSCHKNGAGHGVGGSEGQLVKSVVAAVVGVAGVVALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3M3</accession>
    <name>Q2H3M3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_06742</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222837.1">
        <property type="nucleotide sequence ID" value="XM_001222836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3M3"/>
    <dbReference type="STRING" id="306901.Q2H3M3"/>
    <dbReference type="GeneID" id="4390765"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06742"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_9_0_1"/>
    <dbReference type="InParanoid" id="Q2H3M3"/>
    <dbReference type="OMA" id="FHTHEAT"/>
    <dbReference type="OrthoDB" id="5571888at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF78">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="4">
        <location>
            <begin position="106"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="462"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="500"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="533"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="566"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="601"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ90123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="642" mass="71561" checksum="AB9AD8BDF8737540" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3R4</accession>
    <name>Q2H3R4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH-ubiquinone oxidoreductase 21 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_06701</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222796.1">
        <property type="nucleotide sequence ID" value="XM_001222795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3R4"/>
    <dbReference type="STRING" id="306901.Q2H3R4"/>
    <dbReference type="GeneID" id="4390868"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06701"/>
    <dbReference type="eggNOG" id="ENOG502S1BF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087364_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3R4"/>
    <dbReference type="OMA" id="TVPWFNF"/>
    <dbReference type="OrthoDB" id="196140at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053229">
        <property type="entry name" value="NADH-Q_oxidrdct_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024549">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019721">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 21KDA SUBUNIT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10785">
        <property type="entry name" value="NADH-u_ox-rdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12853">
        <property type="entry name" value="NADH_u_ox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit N-terminal" evidence="2">
        <location>
            <begin position="84"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit C-terminal fungi" evidence="3">
        <location>
            <begin position="178"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ90082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="28649" checksum="4F673A7EED4427EC" modified="2006-03-21" version="1">MPHLWRLLWPCFRADGNTPSPHIPLHPGLRQQQLGAREPRKLQSGNWTDSIAQHIATLNDALSAAKMSNPTTQTYQWPSKTVKTDYPLIDNDPHFMRVVRYARTSDYVHGVAAGVAGPGLLYAMERFAPSQVGKGGFAQAMRLAGFIGLTGGFLYYYQRSILRFYGMSENAREVQMDMREMVDKVKAGEPLYGESKLTPAMQGVAARQSRYSALFFGVLPWFNFVNHSQHGVDTAKYYQQAERELEAERLAKGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3V3</accession>
    <name>Q2H3V3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Xanthine/uracil permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_06662</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222757.1">
        <property type="nucleotide sequence ID" value="XM_001222756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3V3"/>
    <dbReference type="GeneID" id="4391484"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06662"/>
    <dbReference type="eggNOG" id="ENOG502QQ5E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024508_3_2_1"/>
    <dbReference type="InParanoid" id="Q2H3V3"/>
    <dbReference type="OMA" id="RKGSYFF"/>
    <dbReference type="OrthoDB" id="431212at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005345">
        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015853">
        <property type="term" value="P:adenine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015854">
        <property type="term" value="P:guanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337:SF1">
        <property type="entry name" value="XANTHINE_URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="544"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="554"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ90043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="62412" checksum="9A0FF8648BD85E0B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3V5</accession>
    <name>Q2H3V5_CHAGB</name>
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        <recommendedName>
            <fullName evidence="4">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_06660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222755.1">
        <property type="nucleotide sequence ID" value="XM_001222754.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="Q2H3V5">
        <property type="interactions" value="454"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H3V5"/>
    <dbReference type="GeneID" id="4391482"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06660"/>
    <dbReference type="eggNOG" id="KOG1018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025810_8_4_1"/>
    <dbReference type="InParanoid" id="Q2H3V5"/>
    <dbReference type="OMA" id="ITECTLY"/>
    <dbReference type="OrthoDB" id="1701769at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF149">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytidine deaminase-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208493" description="CMP/dCMP-type deaminase domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="214"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="509"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ90041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="551" mass="59017" checksum="4C15C6DBF0E665B8" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3Z6</accession>
    <name>Q2H3Z6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222714.1">
        <property type="nucleotide sequence ID" value="XM_001222713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3Z6"/>
    <dbReference type="GeneID" id="4390575"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06619"/>
    <dbReference type="HOGENOM" id="CLU_1415003_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3Z6"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="192" mass="20860" checksum="49A497929AEEA945" modified="2006-03-21" version="1">MEKWRNGELEVKCSAQSAPADTMAFGERQVSVKYTTYQNKVIIEEDGREKGVEKDGLLMMDSSVFPYDVAAAGVGSQAQRRMRNTPAPNSVGHGRGGQGQGFKGSPEPVPATEVVAWGKGGSWKRRNFLLGSRCGPRSQFRRLPGVGVPARARDVLVFTRHVCFVACSSSCRHHPSRLGSQQPGFVTQHGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4A7</accession>
    <name>Q2H4A7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_06508</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222603.1">
        <property type="nucleotide sequence ID" value="XM_001222602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4A7"/>
    <dbReference type="FunCoup" id="Q2H4A7">
        <property type="interactions" value="900"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H4A7"/>
    <dbReference type="GeneID" id="4389963"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06508"/>
    <dbReference type="eggNOG" id="KOG0979">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004969_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H4A7"/>
    <dbReference type="OMA" id="RFWTSQP"/>
    <dbReference type="OrthoDB" id="10254973at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="94"/>
            <end position="310"/>
        </location>
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            <begin position="1"/>
            <end position="82"/>
        </location>
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        <location>
            <begin position="700"/>
            <end position="844"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ89889.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1069" mass="121981" checksum="00BEEB4DA884FB43" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
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    </gene>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
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            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4D2"/>
    <dbReference type="STRING" id="306901.Q2H4D2"/>
    <dbReference type="GeneID" id="4391339"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06483"/>
    <dbReference type="eggNOG" id="ENOG502S9RI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078580_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4D2"/>
    <dbReference type="OMA" id="MPKERNF"/>
    <dbReference type="OrthoDB" id="5597581at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019007">
        <property type="entry name" value="Wbp11/ELF5/Saf1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09429">
        <property type="entry name" value="Wbp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wbp11/ELF5/Saf1 N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="271" mass="30282" checksum="48BA5F8D3FF48A62" modified="2006-03-21" version="1">MAKERGYNPVQAQRKADKAKAIKKGKSEQQTRRNEKLAQRNPARIQQQIDDLKALKEGGGKITAHEEQALEALEKDLKAVKKAREALGDKAPQFGRGPPRQGQRGDGVLGKRRRDFEDASSSDSDVPDDVRRIPMPRDTPPPIPREILDEWYAKRRAKRNAERASEVEQRKEPEKPAAPVVEVKTVYEAKPVVRDLRKEAVSAFMPAAVRMKIEKGKGQGGLLEPEEADQLENEGYLRSLEPPRAQTGHLEPDQGAGPRQVTLEEVADEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4I5</accession>
    <name>Q2H4I5_CHAGB</name>
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        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
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        <name evidence="10" type="ORF">CHGG_06430</name>
    </gene>
    <organism evidence="10 11">
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        <lineage>
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            <taxon>Sordariomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001222524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4I5"/>
    <dbReference type="STRING" id="306901.Q2H4I5"/>
    <dbReference type="GeneID" id="4390896"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06430"/>
    <dbReference type="eggNOG" id="KOG2889">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039466_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H4I5"/>
    <dbReference type="OMA" id="HTYWKEQ"/>
    <dbReference type="OrthoDB" id="190958at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024767">
        <property type="entry name" value="PRP38_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12871">
        <property type="entry name" value="PRP38_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor 38 C-terminal" evidence="9">
        <location>
            <begin position="171"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="189"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="209"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ89811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="293" mass="33719" checksum="892616133087FC51" modified="2006-03-21" version="1">MSKPAFHRADERRFLDERGSSGALAPNGLNPATIMEKAVRERIVDSYFYKEQCFGVNEADIVDRVVEHVDHIGGVAGIVQKPTPFLCLAFKLLQLAPADDILDEYPRLWRREVQPFLEDRRKLRRKGRDGTTLTYMDVFVDDLLTKDRVCATSLWKMRKRDILEDLELLEPRVSPLGALEDLLEEDEAMENGDDANGDGHESESGFVRSRSRSQTRSRSQTRSRSQTRSRSQTRSRSQTRSRSQTRSRSQTRSRSDSRRRSRSRSGSPRRRSNHDRMDIDKPEAHRSEGEASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H594</accession>
    <name>Q2H594_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein MGR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222266.1">
        <property type="nucleotide sequence ID" value="XM_001222265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H594"/>
    <dbReference type="STRING" id="306901.Q2H594"/>
    <dbReference type="GeneID" id="4390976"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06171"/>
    <dbReference type="HOGENOM" id="CLU_3191260_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H594"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018450">
        <property type="entry name" value="Romo1/Mgr2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10247">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="46" mass="4680" checksum="65C097F2FB2C41D9" modified="2006-03-21" version="1">MPPPPSHPGGVGPSNFDKFKMGAMMGGTVGTIIGFIFGATLPASRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H596</accession>
    <name>Q2H596_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222264.1">
        <property type="nucleotide sequence ID" value="XM_001222263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H596"/>
    <dbReference type="GeneID" id="4390974"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06169"/>
    <dbReference type="eggNOG" id="ENOG502RJ0B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164879_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H596"/>
    <dbReference type="OMA" id="NNDAHPQ"/>
    <dbReference type="OrthoDB" id="4467949at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="122" mass="13490" checksum="C3A04F8409850BC6" modified="2006-03-21" version="1">MTSRNLNQTWRDVVLKQYEADHAADVPFPVRYLIHAPEWQRDISISIPTKIDVAPFRQAVLAFCKARRLADDPAYDGDLLSVRARVSPRPDPSASAPRNDDDAPSPQDDIDQPEPGVAGISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5R9</accession>
    <name>Q2H5R9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="4">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_05996</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222091.1">
        <property type="nucleotide sequence ID" value="XM_001222090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5R9"/>
    <dbReference type="FunCoup" id="Q2H5R9">
        <property type="interactions" value="853"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H5R9"/>
    <dbReference type="GeneID" id="4390952"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05996"/>
    <dbReference type="eggNOG" id="KOG1268">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_5_2_1"/>
    <dbReference type="InParanoid" id="Q2H5R9"/>
    <dbReference type="OMA" id="ASEYRYA"/>
    <dbReference type="OrthoDB" id="15235at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000001">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000002">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GFAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="15"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="392"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="564"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ89377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="715" mass="79404" checksum="AE9677441463EFC6" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6D5</accession>
    <name>Q2H6D5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol phosphate-mannose biosynthesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_05780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221875.1">
        <property type="nucleotide sequence ID" value="XM_001221874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6D5"/>
    <dbReference type="STRING" id="306901.Q2H6D5"/>
    <dbReference type="GeneID" id="4390128"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05780"/>
    <dbReference type="eggNOG" id="KOG3488">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1360271_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6D5"/>
    <dbReference type="OrthoDB" id="311279at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180047">
        <property type="term" value="P:dolichol phosphate mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009914">
        <property type="entry name" value="DPM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039:SF11">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07297">
        <property type="entry name" value="DPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ89161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="201" mass="21467" checksum="9D3BDBEB8897701C" modified="2006-03-21" version="1">MLFDQEAGATKACFGEAPPAGHRGATGSQLSRDLDELHSGHVICNPPPTIARPRQNRARNNTSEPSIHPFQPSFNNGEPTSPNNSTAKHEIEPAQLTNPPKPQLDKLVGLAMLVASSVVFLYYTIWTLLMPFVDSDHPLQNFFPPRVWAIRIPVILVLLGCAVVGSFLSVVMIRSNRKKAAKAKAAAAAAGASGAAGKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7H4</accession>
    <name>Q2H7H4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221486.1">
        <property type="nucleotide sequence ID" value="XM_001221485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7H4"/>
    <dbReference type="GeneID" id="4389994"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05391"/>
    <dbReference type="HOGENOM" id="CLU_1194769_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7H4"/>
    <dbReference type="OMA" id="WIENWAG"/>
    <dbReference type="OrthoDB" id="4733460at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="232" mass="26514" checksum="A7CA811BF60D6743" modified="2006-03-21" version="1">MSSNRGGRFSRGQGDSWGNPQGTRRRTQHRRISQLQGDVKPTARNLLPSEMVKPNKVFVPGMRLEGCGLGFEDITAYYQTGKGTLEDPMVVWLDDDARVGYQSRQAHNEIARSVARANKFQCVLIRKAMHDRECTYDKYGRRNSVCMPDGRIHNVTTQADNHMTVWMGEHMKRILVGGHIYVVRAIDPATRKPYPLPMDDPVNQRNKALLQPGRGLASEEFWLVKDTWERFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7L1</accession>
    <name>Q2H7L1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7L1"/>
    <dbReference type="GeneID" id="4390388"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05354"/>
    <dbReference type="eggNOG" id="ENOG502RVSP">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_359402_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7L1"/>
    <dbReference type="OrthoDB" id="5372708at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="779" mass="88198" checksum="18EB4ACE59C6A2F3" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7Y2</accession>
    <name>Q2H7Y2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor hoxa13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230188.1">
        <property type="nucleotide sequence ID" value="XM_001230187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7Y2"/>
    <dbReference type="STRING" id="306901.Q2H7Y2"/>
    <dbReference type="GeneID" id="4388392"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03672"/>
    <dbReference type="eggNOG" id="ENOG502SGAD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005461_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H7Y2"/>
    <dbReference type="OMA" id="GVAHARY"/>
    <dbReference type="OrthoDB" id="3260408at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23242">
        <property type="entry name" value="TRANSCRIPTION FACTOR HOXA13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23242:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR HOXA13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="758"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1181"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="707"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1193"/>
            <end position="1206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1206" mass="128338" checksum="772FF768BCDC2440" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8C6</accession>
    <name>Q2H8C6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_03528</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230044.1">
        <property type="nucleotide sequence ID" value="XM_001230043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8C6"/>
    <dbReference type="GeneID" id="4388533"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03528"/>
    <dbReference type="eggNOG" id="KOG0773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008497_3_0_1"/>
    <dbReference type="InParanoid" id="Q2H8C6"/>
    <dbReference type="OMA" id="RYDWTRH"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="32"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="238"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="34"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="190"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ91593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="652" mass="72227" checksum="E5F4D3186D509068" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8J8</accession>
    <name>Q2H8J8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_03456</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229972.1">
        <property type="nucleotide sequence ID" value="XM_001229971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8J8"/>
    <dbReference type="STRING" id="306901.Q2H8J8"/>
    <dbReference type="GeneID" id="4389816"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03456"/>
    <dbReference type="eggNOG" id="ENOG502QRET">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035914_1_2_1"/>
    <dbReference type="InParanoid" id="Q2H8J8"/>
    <dbReference type="OMA" id="NHNRVHR"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012158332" description="Tyrosinase copper-binding domain-containing protein" evidence="3">
        <location>
            <begin position="16"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="5">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ91521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="314" mass="35190" checksum="1C4E9E962C02735A" modified="2006-03-21" version="1">MHLAPFIITAGLSAAAIIPRQTNTCDNPIKRVEWRELDPTLQTQYIDALLCLKTKPSEIGLNTTRYDDFPYVHTHLDKSIHTVAMFLPWHRMFVQVYEQALVDCGYTGPMPYWDWTLDTADVTRSPIWDPIHGFGGNGDPSVDPWTESSKKKCLVDGPLQGVVPAYTMGGYEPHCLARNWNNGTAFPGNMFAQHYTTEAVAAIHALEDYASFRYQLEGGPHGAVHSAVGGDMMPATSPNDPIFFLHHTQVDRLWALWQQENPVARNMDFAGPKTQDQNTTEATLDDIMPFMGITPDIKVAEVMEIGTPRLCYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H967</accession>
    <name>Q2H967_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_03237</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="4"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229753.1">
        <property type="nucleotide sequence ID" value="XM_001229752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H967"/>
    <dbReference type="STRING" id="306901.Q2H967"/>
    <dbReference type="GeneID" id="4388630"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03237"/>
    <dbReference type="eggNOG" id="KOG3084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_352657_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H967"/>
    <dbReference type="OrthoDB" id="10249612at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000042">
        <property type="entry name" value="Probable NADH pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015376">
        <property type="entry name" value="Znr_NADH_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09297">
        <property type="entry name" value="Zn_ribbon_NUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="11">
        <location>
            <begin position="635"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="606"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ91302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="797" mass="87723" checksum="0BB13360107121FE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9J7</accession>
    <name>Q2H9J7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="16">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CHGG_03107</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="16"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229623.1">
        <property type="nucleotide sequence ID" value="XM_001229622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9J7"/>
    <dbReference type="FunCoup" id="Q2H9J7">
        <property type="interactions" value="701"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H9J7"/>
    <dbReference type="GeneID" id="4388962"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03107"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001613_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H9J7"/>
    <dbReference type="OMA" id="MVHPKVT"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18037">
        <property type="entry name" value="DEXSc_Pif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001226">
        <property type="entry name" value="ATP-dependent DNA helicase PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="319"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="131"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAQ91172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="743" mass="80798" checksum="217885F65314960C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9X4</accession>
    <name>Q2H9X4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_02980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229496.1">
        <property type="nucleotide sequence ID" value="XM_001229495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9X4"/>
    <dbReference type="GeneID" id="4389003"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02980"/>
    <dbReference type="eggNOG" id="ENOG502SQ20">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037033_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9X4"/>
    <dbReference type="OMA" id="KARRFWW"/>
    <dbReference type="OrthoDB" id="2126185at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="490" mass="53302" checksum="38D0230B2D06D486" modified="2006-03-21" version="1">MAPVEVEREPRTLPIALAGLQVAVAVYASYTVARSLYQSHKALGPAQDTWNRKPERIKLTTAFGSLAALGLAFAVASGLEYLTLSYKVWACERDVPVPESTRHQFRHKRRGMSSMYPSKCIANLARIAQIIHRMLPNKPQNWSPRLSLLLLPLVANYALAFWLPNTTWTSSFPTLVALSKILTLAPLILPAIAPTSWGIVHSDPHDAHPDITKLFNTISAGTIILYTTTTIRALVDNLPDSSKPCHTLLNVPLDTEKRSHWERTATAVERILGSITDHPAVTAAGKDVLLCALSLGLWAAVRSTDVNNMLRSLSPIREFPRCFLSEVSPSKPTKPEPTPGPEDAAHPTPAPSFGMTLRRPRRSARGSISSTGSSNSPGEDTTTTTAAVHEPPKRRGRPRTAKPEPEPELKLKPKQQQHHRQPKQEDALAHDDKTYVPTPAVQAEAGRGLGDVVTEDDFDWESAALAWGVTVLGGLGLGGAAVWGAECLAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9Y1</accession>
    <name>MDM34_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial distribution and morphology protein 34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MDM34</name>
        <name type="ORF">CHGG_02973</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229489.1">
        <property type="nucleotide sequence ID" value="XM_001229488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9Y1"/>
    <dbReference type="SMR" id="Q2H9Y1"/>
    <dbReference type="STRING" id="306901.Q2H9Y1"/>
    <dbReference type="GeneID" id="4389743"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02973"/>
    <dbReference type="eggNOG" id="ENOG502QT3W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036502_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H9Y1"/>
    <dbReference type="OMA" id="VFRAWSG"/>
    <dbReference type="OrthoDB" id="17927at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21673">
        <property type="entry name" value="SMP_Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03105">
        <property type="entry name" value="Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027536">
        <property type="entry name" value="MDM34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058825">
        <property type="entry name" value="MDM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26545">
        <property type="entry name" value="Mdm34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0445">Lipid transport</keyword>
    <keyword id="KW-0446">Lipid-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1134">Transmembrane beta strand</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000384336" description="Mitochondrial distribution and morphology protein 34">
        <location>
            <begin position="1"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="537" mass="59330" checksum="8A613A4CDC44F98F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HA80</accession>
    <name>Q2HA80_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_02874</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229390.1">
        <property type="nucleotide sequence ID" value="XM_001229389.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HA80"/>
    <dbReference type="GeneID" id="4389611"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02874"/>
    <dbReference type="eggNOG" id="KOG1015">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001161_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HA80"/>
    <dbReference type="OMA" id="PWISRNI"/>
    <dbReference type="OrthoDB" id="2020972at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044574">
        <property type="entry name" value="ARIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056026">
        <property type="entry name" value="DUF7607"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797:SF1">
        <property type="entry name" value="HELICASE ARIP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="RAD54-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24580">
        <property type="entry name" value="DUF7607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="769"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="1066"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="292"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="387"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="447"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="635"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1370"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="397"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="639"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="654"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="678"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1370"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1420"/>
            <end position="1431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ90939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1558" mass="172932" checksum="CE3321AAF17A84FE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HB36</accession>
    <name>Q2HB36_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_02568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229084.1">
        <property type="nucleotide sequence ID" value="XM_001229083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HB36"/>
    <dbReference type="STRING" id="306901.Q2HB36"/>
    <dbReference type="GeneID" id="4389325"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02568"/>
    <dbReference type="eggNOG" id="ENOG502S4R7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030267_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HB36"/>
    <dbReference type="OrthoDB" id="2157498at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029164">
        <property type="entry name" value="PIG-Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400:SF1">
        <property type="entry name" value="PIG-P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400">
        <property type="entry name" value="YALI0E29227P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15159">
        <property type="entry name" value="PIG-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ90633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="546" mass="58270" checksum="4BA62C19A6ADCEA9" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBK3</accession>
    <name>Q2HBK3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored serine-threonine rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_02401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228917.1">
        <property type="nucleotide sequence ID" value="XM_001228916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBK3"/>
    <dbReference type="GeneID" id="4389750"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02401"/>
    <dbReference type="eggNOG" id="ENOG502RVZE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_645571_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HBK3"/>
    <dbReference type="OMA" id="NCPGGHT"/>
    <dbReference type="OrthoDB" id="5152093at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209108" description="GPI anchored serine-threonine rich protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ90466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="42421" checksum="5D84B60946649107" modified="2006-03-21" version="1">MQKFILLGLLPSLALAGRISSPFVLRRTDGGGGYDEESCEDLGMQDCGGCIPLDYTCCPAQTGGCPPDQRCVVGDDGEDGCCPEGYTCTGNGGVSSTTFSLTTSTSTSAVVEEPSPTPTGGANEETPPDYGEIPGPTLVDPNPEETPTPTPEPTPEPSPEPTSSEEAETTETTSTPTSSPEAESSTTTEDAAESTTTESASASASETASEEATSTTASEDASSTSAAASTISTTTTVAPTLSASSTLSFSNGTFTTASTTAYTTSTVYTTTTRTITSCPPSHPCQSGTVVTETIAVSTTICPVVENPPLPTPTNTPATIINGGDSTTTTVAPVNTPVVVCPGNGQACSPVDNDNNGGDSDNETPSASSSSVATPPSYTHGGAHPTGSVPKPPMTTGHVPVTAGAARVGQAVSGVVVVLGFAVAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HC38</accession>
    <name>Q2HC38_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_02216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228732.1">
        <property type="nucleotide sequence ID" value="XM_001228731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HC38"/>
    <dbReference type="STRING" id="306901.Q2HC38"/>
    <dbReference type="GeneID" id="4389193"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02216"/>
    <dbReference type="eggNOG" id="KOG1981">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005050_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HC38"/>
    <dbReference type="OMA" id="FHAWKTH"/>
    <dbReference type="OrthoDB" id="276323at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF18">
        <property type="entry name" value="IQ CALMODULIN-BINDING MOTIF DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G08920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="924"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ90281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1179" mass="129918" checksum="AD146C4DB1D5D3E1" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HC52</accession>
    <name>Q2HC52_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aflatoxin biosynthesis ketoreductase nor-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228718.1">
        <property type="nucleotide sequence ID" value="XM_001228717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HC52"/>
    <dbReference type="GeneID" id="4389446"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02202"/>
    <dbReference type="eggNOG" id="KOG1611">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_1_1"/>
    <dbReference type="InParanoid" id="Q2HC52"/>
    <dbReference type="OMA" id="WLTAFPI"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF26">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY OXIDOREDUCTASE (JCVI)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="27556" checksum="115F2E9068C02D26" modified="2006-03-21" version="1">MSPTVVLITGANRGIGRGLLELYLARANHRIIATVRDPNHSTAKKLTTLPRAEGTSLVVVKLDVTVHSDPAAAVQELSAKHGIDHVDVLVANAGIALKWPTVSEVTPQDIQKHVEVNVHGFVVLFQAFRPVLQKAKDPKWVTIGSSAAFLTPPPSHNRNFLPMRNAAYGPTKLVQHWLTKAIHTEEPWLIAFPIDPGWVQTDIGDRGAHAFGIEKAAITVDESVNGIIKVIDAATQETHSGRLWAYTGNEVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCE8</accession>
    <name>Q2HCE8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_02106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221327.1">
        <property type="nucleotide sequence ID" value="XM_001221326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCE8"/>
    <dbReference type="GeneID" id="4386663"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02106"/>
    <dbReference type="eggNOG" id="ENOG502QS1D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_847308_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCE8"/>
    <dbReference type="OrthoDB" id="9978204at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15892">
        <property type="entry name" value="BNR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ93871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="328" mass="36875" checksum="28FFA3ABDE5C9CE7" modified="2006-03-21" version="1">MGLMQVLLTPPTLPGPTMLGCQAPIPVVDYSRHHFSTNQRPSAGCLRVRARRNAISSTCLFQLPGAGPSGRFDAVSSHLSTDAEMLPEPNVTVLGQDSGQRRRFSINCYSFQQDAVVTFNGWQYACFYSFLESEPSGASPEPLYVHLARRQLPRGEWEVMVFDDYAQTTDDGHNTIQMGVCSADGTIHLSFDHHCDALKYRFSVPDITTWPTDFEWRPSLFTPTLSHLPGLPMTDPKFKDVTYPRFGPCGSSMFFSFRDGKAGLGNDHLYMYMPSKQQFVFVGTHLTGIQSNPYVHGMDWRRGRLLRHMGVPRLRVLRRLGRLAGHPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCN2</accession>
    <name>Q2HCN2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_02022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221243.1">
        <property type="nucleotide sequence ID" value="XM_001221242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCN2"/>
    <dbReference type="GeneID" id="4388122"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02022"/>
    <dbReference type="eggNOG" id="KOG2352">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2372588_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCN2"/>
    <dbReference type="OMA" id="QTPTHEW"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ93787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="95" mass="10889" checksum="89A2E80AF703A247" modified="2006-03-21" version="1">MSAVEEALSKPEYWDKHYSKSDGQTPTHEWFRSFNDLEEFFQSPLFDAPGFTPPDNPVILHLGSGDNLQILGGHNGGFEYYGWVIRKARSKEQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCX5</accession>
    <name>Q2HCX5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221150.1">
        <property type="nucleotide sequence ID" value="XM_001221149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCX5"/>
    <dbReference type="GeneID" id="4386479"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01929"/>
    <dbReference type="eggNOG" id="ENOG502S6IQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029955_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HCX5"/>
    <dbReference type="OrthoDB" id="5377213at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="435" mass="47748" checksum="557FA11FE6911E87" modified="2006-03-21" version="1">MASVGSGQSGTSVTKITKARGKMVKPILKRLSHSEKNSLDLDRGWDEQQIEQLTAGGMGGWVIRGRREMSVLAFLVLPVSGQVMRWRRWVGEVPSEQTSSFNTVVPVLKLRLEADLAQRDCAPATGLGASPACFQRPSLNGHRASSFPDTPASKPPSLRINTSGRSVSGTTATSSRLAHGNIPSPSHSELNLDSYNLSISLSGTLDSPTGSLGAGSVIASPQQQQSQLSPLRASLDMGVFPNLRRSELDTATRDENIRVARRKFEEREREKEEKYDREMIRKRERQDNKEASRIEKGEAPSRPLMHRKKTATGLSTVSEPGPKSARPDLSTSLFGFSAPARTSGVVLGVGKRRHTDSPTMTKGEKQVGFASRRYESVSLLPQTPPSFGVTVDDMPFERPQPRRGSGAKSAKQKTQGYWQGFLLWLRTKLLRMNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HD31</accession>
    <name>Q2HD31_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221094.1">
        <property type="nucleotide sequence ID" value="XM_001221093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HD31"/>
    <dbReference type="GeneID" id="4386421"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01873"/>
    <dbReference type="HOGENOM" id="CLU_1834930_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HD31"/>
    <dbReference type="OrthoDB" id="10680717at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="140" mass="15259" checksum="7316484E831476E7" modified="2006-03-21" version="1">MLSRRPGLGLNLPLQFLVGRRRRTRGLILFPVPIGATESVYITILPFDGAAFGAVSKHLDETVLSRAHHDAPVDIHAETHPVVRALHPLYDPLALDVPHDNVAVLARRCYERLLSALVIVSGMFLAPVVAVSEHAKAPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDS9</accession>
    <name>Q2HDS9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CHGG_01625</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 23">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220846.1">
        <property type="nucleotide sequence ID" value="XM_001220845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDS9"/>
    <dbReference type="FunCoup" id="Q2HDS9">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HDS9"/>
    <dbReference type="GeneID" id="4387095"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01625"/>
    <dbReference type="eggNOG" id="KOG1819">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022550_3_0_1"/>
    <dbReference type="InParanoid" id="Q2HDS9"/>
    <dbReference type="OMA" id="ICHTQFS"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16489">
        <property type="entry name" value="mRING-CH-C4HC2H_ZNRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051878">
        <property type="entry name" value="ZNRF_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNRF1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="20">
        <location>
            <begin position="336"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="650"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="156"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="250"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="421"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="602"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="429"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="602"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EAQ93390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="698" mass="75271" checksum="0D29404B3449AF34" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEI6</accession>
    <name>Q2HEI6_CHAGB</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="InParanoid" id="Q2HEI6"/>
    <dbReference type="OrthoDB" id="10423976at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="108" mass="11454" checksum="BB4E25FBBF2291C8" modified="2006-03-21" version="1">MPCMTILPKLPLAGWVFLGTPADWMSVALHARHHGVHPAANQLSEIRRDQAVAGAGLPANSRHHLGATNGHKWATNGPPRPGILQPDRAEFPPVDPGTLASHTESAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEM1</accession>
    <name>Q2HEM1_CHAGB</name>
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        <recommendedName>
            <fullName evidence="3">ATP-dependent DNA helicase</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">CHGG_01333</name>
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001220553.1"/>
    </dbReference>
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    <dbReference type="STRING" id="306901.Q2HEM1"/>
    <dbReference type="GeneID" id="4386429"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01333"/>
    <dbReference type="eggNOG" id="KOG0987">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF6">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ93098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="38109" checksum="E1E6EF9CD28DCC76" modified="2006-03-21" version="1">MPTWTRTPWWTGPPGDVPTSSLIISDGLSDVHKNETTDPEMLVIASFDWFRQQGEDQAPFRRALEELRIADVSVSSWELLSSRRSVKLSPEEVDSFADALRIYPTKGQVVEYNHHHMLGLDSPAIQVEAKHDGVGVEKVESSNAGNLAKRLPLCVGCRVMLTRNLWAGSPGSLTAHRGQSTTYPGKKVPTCCETRPRSSWWPSMTTTARPSRCRTGSRSVVERSWLFPILRVRQDFKGANSCSREQFSLWVSYAITVHKSQGIILDKVVCDISAPEFASSLSYVAVSRVKTLGGLMFERPFDRSSIYRETPSRAMGLKLSDHATRQLQALDAVAGEAPSEESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEV5</accession>
    <name>Q2HEV5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_01249</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220470.1">
        <property type="nucleotide sequence ID" value="XM_001220469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEV5"/>
    <dbReference type="STRING" id="306901.Q2HEV5"/>
    <dbReference type="GeneID" id="4387567"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01249"/>
    <dbReference type="eggNOG" id="KOG1287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_340391_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HEV5"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF402">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="566"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="596"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="127"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="729"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ93014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="834" mass="88211" checksum="ADA75F6E8DACADD9" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-11-02" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEW4</accession>
    <name>CHEB_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl reductase cheB</fullName>
            <ecNumber evidence="8">1.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Chaetoglobosin A biosynthesis cluster protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cheB</name>
        <name type="ORF">CHGG_01240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2013" name="J. Am. Chem. Soc." volume="135" first="7371" last="7377">
            <title>Combinatorial generation of complexity by redox enzymes in the chaetoglobosin A biosynthesis.</title>
            <authorList>
                <person name="Ishiuchi K."/>
                <person name="Nakazawa T."/>
                <person name="Yagishita F."/>
                <person name="Mino T."/>
                <person name="Noguchi H."/>
                <person name="Hotta K."/>
                <person name="Watanabe K."/>
            </authorList>
            <dbReference type="PubMed" id="23611317"/>
            <dbReference type="DOI" id="10.1021/ja402828w"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2021" name="Fungal Biol." volume="125" first="201" last="210">
            <title>Functional analysis of a chaetoglobosin A biosynthetic regulator in Chaetomium globosum.</title>
            <authorList>
                <person name="Cheng M."/>
                <person name="Zhao S."/>
                <person name="Liu H."/>
                <person name="Liu Y."/>
                <person name="Lin C."/>
                <person name="Song J."/>
                <person name="Thawai C."/>
                <person name="Charoensettasilp S."/>
                <person name="Yang Q."/>
            </authorList>
            <dbReference type="PubMed" id="33622536"/>
            <dbReference type="DOI" id="10.1016/j.funbio.2020.10.010"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5 9">Enoyl reductase; part of the gene cluster that mediates the biosynthesis of chaetoglobosin A which has a unique inhibitory activity against actin polymerization in mammalian cells (PubMed:23611317, PubMed:33622536). Chaetoglobosin A and its intermediates are involved in the morphological differentiation of C.globosum (PubMed:33622536). The first step of the pathway is the synthesis of prochaetoglobosin I via condensation of one acetyl-CoA, 8 malonyl-CoA, and a L-tryptophan molecule by the PKS-NRPS hybrid synthetase cheA, followed by reduction of backbone double bond to install desired geometry by the enoyl reductase cheB (PubMed:23611317). Further multiple oxidation steps performed by the cytochrome P450 monooxygenases cheE and cheG, as well as by the FAD-linked oxidoreductase cheF, lead to the formation of chaetoglobosin A (PubMed:23611317). Depending on the order of action of these reductases, distinct intermediates can be identified (PubMed:23611317). Within the pathway, the cytochrome P450 monooxygenase cheE catalyzes a stereospecific epoxidation on prochaetoglobosin I, cytoglobosin D, and chaetoglobosin J intermediates (PubMed:23611317). The FAD-linked oxidoreductase cheF performs dehydrogenation of the C-20 hydroxyl groups in the 20-dihyrochaetoglobosin A and cytoglobosin D intermediates (PubMed:23611317). Finally, the cytochrome P450 monooxygenase cheG can catalyze the stereospecific dihydroxylation of prochaetoglobosin I and prochaetoglobosin IV at C-19 and C-20, respectively (PubMed:23611317). The Diels-Alderase cheD may play a role in the post-PKS-NRPS biosynthetic steps catalyzing Diels-Alder cyclization.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="induction">
        <text evidence="5">Expression is positively regulated by the cluster-specific transcription factor cheR that binds directly to an asymmetric direct repeat present in the promoter.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Abolishes the production of chaetoglobosin A and 20-dihyrochaetoglobosin A (PubMed:23611317).</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220461.1">
        <property type="nucleotide sequence ID" value="XM_001220460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEW4"/>
    <dbReference type="SMR" id="Q2HEW4"/>
    <dbReference type="FunCoup" id="Q2HEW4">
        <property type="interactions" value="206"/>
    </dbReference>
    <dbReference type="GeneID" id="4387646"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01240"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_1_1"/>
    <dbReference type="InParanoid" id="Q2HEW4"/>
    <dbReference type="OMA" id="DFKMPLR"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="BioCyc" id="MetaCyc:MONOMER-19095"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF1">
        <property type="entry name" value="TRANS-ENOYL REDUCTASE STHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000438242" description="Enoyl reductase cheB">
        <location>
            <begin position="1"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Enoyl reductase (ER) domain" evidence="3">
        <location>
            <begin position="18"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="137"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="173"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="200"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="265"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="285"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="354"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P04798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9Y7D0"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="23611317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="33622536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="33622536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000305" key="8">
        <source>
            <dbReference type="PubMed" id="23611317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9">
        <source>
            <dbReference type="PubMed" id="33622536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ93005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="377" mass="40831" checksum="5CFA3E6D5F7177D1" modified="2006-03-21" version="1">MGSFEIPEKHTALLQGEGGSLVIARDVPLPTLGPGHLLVKTAAVALNPCDFKTPAAFPNPGYYNGCDFAGTVVALGSDNIRDGGPWKIGDRIFGAIHGANPSDWDSGSHAEYVKAVSVFSYRIPDWMTFEEAAGLSPCCIATMGVSLFKALELPGTFEEPATKPLDVLIYGGSSSVGSLGIQMVKLTGHRLGHRCITTCSPKNFDLVKSYGADEVFDYKSPTCAQDIRKATRNCLKYAVDPFGEVKTMAICTEAIGRAGGRYSALEKFQEDVCDRKTVKRELTMGAIIIGHGLDLGGRYTRPHSPEMRAWGIEWYKSIQRLVDARKFKPHPIRVLKGGFEDMLEGLAMLKRREISAEKLVVSLDPAVSGLTADSTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HF71</accession>
    <name>Q2HF71_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_01133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220354.1">
        <property type="nucleotide sequence ID" value="XM_001220353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HF71"/>
    <dbReference type="GeneID" id="4387963"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01133"/>
    <dbReference type="eggNOG" id="ENOG502RPHE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1911769_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HF71"/>
    <dbReference type="OMA" id="MASCDSW"/>
    <dbReference type="OrthoDB" id="3641074at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ92898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="154" mass="17061" checksum="01D26D826DF23D51" modified="2006-03-21" version="1">MASCDSWRVFSTMRTAESWCKQFLGMPCWKRDDTTAVALSVDKRAAEPWCTQFLGQPCWKRNGDDTSAVEKREAEAAAEPDRFCTRFTGSSCWKRDGGAVAAEEVKRCSSEGQACWKAKRAAAAVTNAIDEGNAQKMARDADPGWCRQFLGMPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFA8</accession>
    <name>Q2HFA8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220317.1">
        <property type="nucleotide sequence ID" value="XM_001220316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFA8"/>
    <dbReference type="GeneID" id="4386602"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01096"/>
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    <dbReference type="InParanoid" id="Q2HFA8"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="43" mass="4237" checksum="E40B16F3438E1732" modified="2006-03-21" version="1">MASQAAQMPSIGSSVAPAVKAQATDAASKPKVRQQHQNSGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFZ2</accession>
    <name>Q2HFZ2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Saccharopine dehydrogenase [NAD(+), L-lysine-forming]</fullName>
            <shortName evidence="14">SDH</shortName>
            <ecNumber evidence="5 14">1.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Lysine--2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CHGG_00862</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NAD(+)-dependent cleavage of saccharopine to L-lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysin biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>L-saccharopine + NAD(+) + H2O = L-lysine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="EC" id="1.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.7" evidence="5 14"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220083.1">
        <property type="nucleotide sequence ID" value="XM_001220082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFZ2"/>
    <dbReference type="FunCoup" id="Q2HFZ2">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HFZ2"/>
    <dbReference type="GeneID" id="4387342"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00862"/>
    <dbReference type="eggNOG" id="KOG0172">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063085_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HFZ2"/>
    <dbReference type="OMA" id="YFFFSHT"/>
    <dbReference type="OrthoDB" id="265306at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004754">
        <property type="term" value="F:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12188">
        <property type="entry name" value="SDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000217">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AASS"/>
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    </dbReference>
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        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
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        <property type="entry name" value="Lys1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF23">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE [NAD(+), L-LYSINE-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018250">
        <property type="entry name" value="Saccharopine_DH_Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 14" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9 14 16" id="KW-0520">NAD</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="19">
        <location>
            <begin position="7"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="18">
        <location>
            <begin position="173"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="200"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="319"/>
            <end position="322"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="202"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00033228"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EAQ92627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="375" mass="40751" checksum="3BEFF31E14D30896" modified="2006-03-21" version="1">MAPTVLHLRSETKPLEHRSALTPTTTAALIKAGYTVNVERSPVRIFDDAEFEAAGATLVPEYSWVDAPKEHIIIGLKELEEKEFPLKHVHVQFAHCYKQQGGWETVLARFPRGGGTLLDLEFLVDENGRRVAAFGYHAGFAGAALALEVWSWQLNHSEPFPGVESYPNEDALVSNVKKALASGIEKAGRSPRVIVIGALGRCGSGAVEALRKAGVPEENILKWDMAETAGGGPFKEITDSDIFVNCIYLTKKIPNFVNLESLQVPDRKLSVVCDVSAASQDTTSPFTPVPIYTVATTFDEPTVAVEGLQSGPALSVISIDHLPSLLPREASEAFSQDLLPSLLALNDWQNTPVWSRADKLFKEKVATLPASALEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGK9</accession>
    <name>Q2HGK9_CHAGB</name>
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        <recommendedName>
            <fullName evidence="5">Spray</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Untereiner W.A."/>
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                <person name="Grabherr M."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00645"/>
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    <dbReference type="HOGENOM" id="CLU_004027_0_0_1"/>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="416"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="586"/>
            <end position="608"/>
        </location>
    </feature>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="745"/>
            <end position="768"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ92410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="828" mass="90140" checksum="9312BC85F7C010B9" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHC6</accession>
    <name>Q2HHC6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">UDP-glucose:glycoprotein glucosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_00378</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219599.1">
        <property type="nucleotide sequence ID" value="XM_001219598.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2HHC6">
        <property type="interactions" value="436"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HHC6"/>
    <dbReference type="GeneID" id="4387944"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00378"/>
    <dbReference type="eggNOG" id="KOG1879">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002668_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HHC6"/>
    <dbReference type="OMA" id="RQTKTRF"/>
    <dbReference type="OrthoDB" id="27683at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06432">
        <property type="entry name" value="GT8_HUGT1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040497">
        <property type="entry name" value="Glyco_transf_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040525">
        <property type="entry name" value="UGGT_TRXL_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18404">
        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18403">
        <property type="entry name" value="Thioredoxin_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="10">
        <location>
            <begin position="37"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="11">
        <location>
            <begin position="263"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="12">
        <location>
            <begin position="401"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="12">
        <location>
            <begin position="446"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose:glycoprotein glucosyltransferase thioredoxin-like" evidence="13">
        <location>
            <begin position="627"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="14">
        <location>
            <begin position="1125"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1343"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1393"/>
            <end position="1406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ92143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1406" mass="157114" checksum="CFC8E79B862E5AC8" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI16</accession>
    <name>Q2HI16_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dihydrolipoyl dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_00138</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="6">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219359.1">
        <property type="nucleotide sequence ID" value="XM_001219358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HI16"/>
    <dbReference type="SMR" id="Q2HI16"/>
    <dbReference type="STRING" id="306901.Q2HI16"/>
    <dbReference type="GeneID" id="4387866"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00138"/>
    <dbReference type="eggNOG" id="KOG1335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_1_2_1"/>
    <dbReference type="InParanoid" id="Q2HI16"/>
    <dbReference type="OMA" id="SHCLMAV"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43014">
        <property type="entry name" value="MERCURIC REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43014:SF2">
        <property type="entry name" value="MERCURIC REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="9">
        <location>
            <begin position="12"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="8">
        <location>
            <begin position="354"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="143"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="181"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="7">
        <location>
            <begin position="45"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ91903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="49321" checksum="9D6DAEE4122657DA" modified="2006-03-21" version="1">MATPEQYDFIALGGGEPAKLLAWDLSSKYGKKCAVIEHGPISGACPTVACMPTKTLLHSAQLAHLARQAQASTPGAAGNGFNADMAKVFARKQEVVDGMADLFLGIFAETKAELIRGHGEFVDPKTISCNGRLLTAETVLINTGSKAFVDTSIPGLADANPLTHVELLDIKTLPSHLIILGGGYVGIEFAQAYARFGSRVTVIERNAQILAKEDSDVVAELTRLLAREGIDFLTSTSVTHVSGTSGSEVTLTLSHPTPGAGAAPTSIRGTHLLVAAGRTPTTANLGLAAAGIKLTPTGHIAVDAQLRTSVPGVFAAGDCAGSPYFTHMGWDDYRVLLGVVTGAPREAGTMGRQVPSVLFTTPELAHVGLREEEAKKKGVGYRVVRAPMGAFLRARALGETEGFAKALVEEEGERVLGFTALGPGAGELLPVVQLVMKLGLSYKELVDLTIVHPTMAEGLVDLFRSVPPSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI44</accession>
    <name>Q2HI44_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sphingoid long-chain base transporter RSB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_00110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219331.1">
        <property type="nucleotide sequence ID" value="XM_001219330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HI44"/>
    <dbReference type="GeneID" id="4388054"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00110"/>
    <dbReference type="eggNOG" id="ENOG502QU4U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_6_1_1"/>
    <dbReference type="InParanoid" id="Q2HI44"/>
    <dbReference type="OMA" id="HEPSFIV"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ91875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="32944" checksum="55EB8827D13E9EA7" modified="2006-03-21" version="1">MSKHELPAGYRPSYEVCTEPSPYCPVQATTLGYFPNEGVNIFLAIGYALAALITLSIGYIGRVLLASNPWNGGAFKLQIVAIILGPTLVCVGLYLTLKHAVVALNRSFSRVAPRVYPLFFVPADISCLVIQAIGGGIAASAGRDSYQLLQHGNRTIMAGIVLQVLVLATFGAVAGDYLFRVGRYFKSGNVAPEYQEGAALWVTKKFRMFVWAIAVAYATLLIRCIYRIAEMAGGWGNHIMQDEPSFIVLESFMVLIACLLLAVFAPGIFFPQMSHSFVSAGAVPEAEKQPQTESDSAGFEMDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI68</accession>
    <name>Q2HI68_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219307.1">
        <property type="nucleotide sequence ID" value="XM_001219306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HI68"/>
    <dbReference type="GeneID" id="4387580"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00086"/>
    <dbReference type="HOGENOM" id="CLU_482311_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HI68"/>
    <dbReference type="OrthoDB" id="10438571at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="565" mass="63020" checksum="7CC6D0A3376B156D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM22</accession>
    <name>Q2GM22_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T1</fullName>
            <ecNumber evidence="2">4.6.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_10982</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[RNA] containing guanosine + H2O = an [RNA fragment]-3'-guanosine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA fragment].</text>
            <dbReference type="EC" id="4.6.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease N1/T1 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.24" evidence="2"/>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226249.1">
        <property type="nucleotide sequence ID" value="XM_001226248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GM22"/>
    <dbReference type="GeneID" id="4397286"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10982"/>
    <dbReference type="eggNOG" id="ENOG502SA4T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111658_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GM22"/>
    <dbReference type="OMA" id="NHERFFN"/>
    <dbReference type="OrthoDB" id="5425539at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046589">
        <property type="term" value="F:ribonuclease T1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104:SF1">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="139"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ83164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="213" mass="21790" checksum="8AEF6DA5E2958F3A" modified="2006-03-21" version="1">MPRLATGGCEPSNRAKGTSDITSVTCGKTTYTRDQIEDAVFEGCRLHAAGEQLGNSRYPHRFNNREGLTFSTSGPYQEFPILSNGNVYSGKNKHTTLTPTPGSPGADRVVFNPDYQGSCVYAGAMTHTGAPTRNGFVECEEETGGSDSGSGSGSGTTSSVSPSRTTISGTVSGAAPTATGTGEPEDNAAAVKGVMGMGVQGVVVGLVGGLLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM62</accession>
    <name>Q2GM62_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="3 8">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_10942</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="3 8"/>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226209.1">
        <property type="nucleotide sequence ID" value="XM_001226208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GM62"/>
    <dbReference type="STRING" id="306901.Q2GM62"/>
    <dbReference type="GeneID" id="4397087"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10942"/>
    <dbReference type="eggNOG" id="ENOG502QSWP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025694_1_2_1"/>
    <dbReference type="InParanoid" id="Q2GM62"/>
    <dbReference type="OMA" id="NWIRDVG"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208371" description="Mannan endo-1,6-alpha-mannosidase" evidence="10">
        <location>
            <begin position="26"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="393"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ83124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="453" mass="48869" checksum="6256C94089CEBDAB" modified="2006-03-21" version="1">MGWTTAPKATALLGALLLAAPGASAQAAKLKVDLDSPSSIRSAAKVVAANLMTYYHGDEPGQTPGILPGPPPAAPYYWWQAGAMWGTIVDYWFYTGDNQYNAEALRSMVFQAEAPVNAYMPRNWTASLGNDDQGFWGMAAMLAAEVNFPNPPEDQPQWLALAQAVFNTQVVRWETADCAGGLRWQVEHTNGGYDYKNTIANGRVPQHRLAPGPLHPERDDYNVMDGGHIPFNCTDVNPVQFSANAAILIHAAAVMYNYTEGNARTKWKGRVAGLLNRTVEHFFPDGIMIERACELEDRVQCNTDQHSFKGYMHRALATVAVLAPFTYDDVLKTLRSSTEGAVTSCLSDGTCGFRWNTGEYDNDVAAGPAGQQMSALAALSTLLIDQQKVLNGPLTNQTGGTSKGDPNAGQKFQGLSPPREITAGDRAGSGILTAVVLASFLGSVVWMGMSWSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM69</accession>
    <name>Q2GM69_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TRAPPC10/Trs130 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226202.1">
        <property type="nucleotide sequence ID" value="XM_001226201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GM69"/>
    <dbReference type="STRING" id="306901.Q2GM69"/>
    <dbReference type="GeneID" id="4397161"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10935"/>
    <dbReference type="eggNOG" id="KOG1931">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_438045_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GM69"/>
    <dbReference type="OMA" id="NADTHEQ"/>
    <dbReference type="OrthoDB" id="10256906at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045126">
        <property type="entry name" value="TRAPPC10/Trs130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056913">
        <property type="entry name" value="TRAPPC10/Trs130_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251">
        <property type="entry name" value="EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23036">
        <property type="entry name" value="TRAPPC10_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="2">
        <location>
            <begin position="146"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="2">
        <location>
            <begin position="293"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="665" mass="71583" checksum="EA7E2F7D220CF1DD" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMD8</accession>
    <name>Q2GMD8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Squalene synthase</fullName>
            <shortName evidence="15">SQS</shortName>
            <shortName evidence="15">SS</shortName>
            <ecNumber evidence="4 15">2.5.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_10866</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 (2E,6E)-farnesyl diphosphate + NADH + H(+) = squalene + 2 diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:32299"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 (2E,6E)-farnesyl diphosphate + NADPH + H(+) = squalene + 2 diphosphate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:32295"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.21" evidence="4 15"/>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226133.1">
        <property type="nucleotide sequence ID" value="XM_001226132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMD8"/>
    <dbReference type="FunCoup" id="Q2GMD8">
        <property type="interactions" value="270"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GMD8"/>
    <dbReference type="GeneID" id="4397154"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10866"/>
    <dbReference type="eggNOG" id="KOG1459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031981_2_1_1"/>
    <dbReference type="InParanoid" id="Q2GMD8"/>
    <dbReference type="OMA" id="GEACQLM"/>
    <dbReference type="OrthoDB" id="431150at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045338">
        <property type="term" value="P:farnesyl diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902767">
        <property type="term" value="P:isoprenoid biosynthetic process via mevalonate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000003">
        <property type="entry name" value="Farnesyl-diphosphate farnesyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006449">
        <property type="entry name" value="Squal_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01559">
        <property type="entry name" value="squal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626:SF2">
        <property type="entry name" value="SQUALENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAQ83048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="469" mass="53815" checksum="FAA103AE05B36510" modified="2006-03-21" version="1">MGAARNALYYLVHPNQLRSIIQWKVWHEPVHRRNTEDETETEAACFQYLDLTSRSFSAVIKELNPELLMPICLFYLVLRGLDTIEDDMTIDIKEKEPLLRNFSVHMEQDGWTFDKNGPNEKDRELLVHFDSVIVELKKVKKPYYEIIKDITIKMGNGMADYAINAEHNVNGVNTIEEYELYCHYVAGLVGEGLTRLFVASELANPQLLVRTDLTESMGQMLQKVNIIRDVHEDWVDKRRFWPKEIWSQYVTNWDDLFALENREKALQCSSHMVLNALKHADECLFYMAGIRDQSVFNFVAIPQSMAMATLELVFRNPAVFERNIKITKGDACQLMIESTQNLRVVCDVFRKYVKRIHKKNDPRDPNYLAISTQCGKIEQFIESIFPTQDPKKIEAAAKPAEPTMDTGEAFMLVTSVIATLALIGLLMVGLAWFMGARMDKFFNNMDNFLGGSAPKVTPSLIPVPGRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMN8</accession>
    <name>Q2GMN8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_10766</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ82948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226033.1">
        <property type="nucleotide sequence ID" value="XM_001226032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMN8"/>
    <dbReference type="FunCoup" id="Q2GMN8">
        <property type="interactions" value="544"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GMN8"/>
    <dbReference type="GeneID" id="4397258"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10766"/>
    <dbReference type="eggNOG" id="KOG0937">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026996_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GMN8"/>
    <dbReference type="OMA" id="KPLIWCD"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09250">
        <property type="entry name" value="AP-1_Mu1_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="6">
        <location>
            <begin position="155"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ82948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="436" mass="49347" checksum="88D85E07377D5F34" modified="2006-03-21" version="1">MASAVFFLDLKGKTLLARNYRGDIPMSAVEMFPVLLSEAEEESSAYLYIRHNNLYLLALTKRNTNAAEILLFLHKIVEVFTEYFKALEEESIRDNFVVIYELLDEMMDFGYPQTTESKILQEYITQESHKLEIARPPIAVTNAVSWRSEGIRYRKNEVFLDVVESLNLLVSANGNVLRSEILGAIKMKCYLSGMPELRLGLNDKVMFETTGRTTRGKAIEMEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTQVKPLIWVECVVESHSGSRIEYMLKARAQFKRRSTANNVEIIVPVPDDADTPRFRTNVGSVHYAPEQSAIVWKIKQFGGGKEFLMRAELGLPSVRGDDEHGGGMTGGFGGSMGGIGAPGKGAKRPIQVKFEIPYFTTSGIQVRYLKITEPKLQYPSLPWVRYITQSGDIAVRLPDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPK6</accession>
    <name>Q2GPK6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">superoxide dismutase</fullName>
            <ecNumber evidence="2">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_10098</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228025.1">
        <property type="nucleotide sequence ID" value="XM_001228024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPK6"/>
    <dbReference type="STRING" id="306901.Q2GPK6"/>
    <dbReference type="GeneID" id="4396655"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10098"/>
    <dbReference type="eggNOG" id="KOG0876">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031625_2_3_1"/>
    <dbReference type="InParanoid" id="Q2GPK6"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="7">
        <location>
            <begin position="39"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ83694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="171" mass="18306" checksum="52B27E9DDBF6D0D2" modified="2006-03-21" version="1">MSSTLLRTVPALRGALRASGAPKAAGAMASTSFVRGKATLPDLAYDYGALEPHISGKIMELHHAKHHQTYVNGLNSALQTIGEAESKGDFTKAATVAPLLNFHGGGHINHSLFWENLAPASRDGGGEPDGALRVYVVPPSPLGTRTRKAEYFDAIWNVINWKTVASRYEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPP4</accession>
    <name>Q2GPP4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_10060</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227987.1">
        <property type="nucleotide sequence ID" value="XM_001227986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPP4"/>
    <dbReference type="STRING" id="306901.Q2GPP4"/>
    <dbReference type="GeneID" id="4396580"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10060"/>
    <dbReference type="eggNOG" id="KOG1065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000631_11_0_1"/>
    <dbReference type="InParanoid" id="Q2GPP4"/>
    <dbReference type="OMA" id="QCKYGYW"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF95">
        <property type="entry name" value="ALPHA_BETA-GLUCOSIDASE AGDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208860" description="alpha-glucosidase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="10">
        <location>
            <begin position="86"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="9">
        <location>
            <begin position="265"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="11">
        <location>
            <begin position="668"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="448"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ83656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="858" mass="96206" checksum="4BD366045C9F5DEE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPY9</accession>
    <name>Q2GPY9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="21">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CHGG_09965</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19 21">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="20">Heterotetramer. Consists of 4 subunits: POL2, DPB2, DPB3 and DPB4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 21">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="21"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227892.1">
        <property type="nucleotide sequence ID" value="XM_001227891.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2GPY9">
        <property type="interactions" value="623"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GPY9"/>
    <dbReference type="GeneID" id="4396550"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09965"/>
    <dbReference type="eggNOG" id="KOG1798">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000556_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GPY9"/>
    <dbReference type="OMA" id="MLDQCRY"/>
    <dbReference type="OrthoDB" id="10060449at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05779">
        <property type="entry name" value="DNA_polB_epsilon_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05535">
        <property type="entry name" value="POLBc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000002">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000005">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000015">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000006">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
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            <end position="2024"/>
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        </location>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
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                <person name="Untereiner W.A."/>
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            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ83480.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
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            <dbReference type="PubMed" id="25720678"/>
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            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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        <subcellularLocation>
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        <property type="term" value="C:UTP-C complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
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        <location>
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    </feature>
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        <location>
            <begin position="439"/>
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    <feature type="domain" description="Nrap protein" evidence="10">
        <location>
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    </feature>
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        <location>
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    </feature>
    <feature type="domain" description="Nrap protein" evidence="12">
        <location>
            <begin position="931"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1034"/>
            <end position="1056"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ83279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1086" mass="121683" checksum="18ADA20E368CE05E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQX4</accession>
    <name>Q2GQX4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_09630</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227557.1">
        <property type="nucleotide sequence ID" value="XM_001227556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQX4"/>
    <dbReference type="STRING" id="306901.Q2GQX4"/>
    <dbReference type="GeneID" id="4396559"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09630"/>
    <dbReference type="eggNOG" id="KOG3025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116822_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQX4"/>
    <dbReference type="OMA" id="MKRQTIQ"/>
    <dbReference type="OrthoDB" id="438052at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18182">
        <property type="entry name" value="ATP-synt_Fo_c_ATP5G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031:SF13">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="9">
        <location>
            <begin position="87"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ83226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="141" mass="14730" checksum="7052E2F180579478" modified="2006-03-21" version="1">MASTRVLASRLASQMATKAARPAARVTLANTSKRTLTVASKSSPLQAVKRQQMSSIINATTRQAFTVQRRAYSSEIAQAMVEVSKNLGMGAAAIGLTGAGIGIGLVFAALLNGVARNPALRGQLFSYAILGFAFWSIDIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GR31</accession>
    <name>Q2GR31_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_09573</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227500.1">
        <property type="nucleotide sequence ID" value="XM_001227499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GR31"/>
    <dbReference type="STRING" id="306901.Q2GR31"/>
    <dbReference type="GeneID" id="4395543"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09573"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_0_1"/>
    <dbReference type="InParanoid" id="Q2GR31"/>
    <dbReference type="OMA" id="ENITAMF"/>
    <dbReference type="OrthoDB" id="4457643at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="33"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="486"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ85559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="542" mass="61265" checksum="12274FD87A533E2B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRB4</accession>
    <name>Q2GRB4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_09490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227417.1">
        <property type="nucleotide sequence ID" value="XM_001227416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRB4"/>
    <dbReference type="GeneID" id="4395666"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09490"/>
    <dbReference type="HOGENOM" id="CLU_2960568_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRB4"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ85476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="59" mass="6272" checksum="A838EAF364E60C70" modified="2006-03-21" version="1">MASSSAFNNYIVDSAMGPTCSRQVPPGSFGVPARSGHGHFCACDRCPHLQVFRSIVVSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GS72</accession>
    <name>Q2GS72_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_09182</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Required to prevent the proteolysis of the CreB deubiquitinating enzyme in the absence of carbon catabolite repression. CreB deubiquitinating enzyme stabilized in a complex with the CreC leads to the expression of genes such as those in the proline and quinate pathways.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with creB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat creC family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227109.1">
        <property type="nucleotide sequence ID" value="XM_001227108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GS72"/>
    <dbReference type="STRING" id="306901.Q2GS72"/>
    <dbReference type="GeneID" id="4394911"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09182"/>
    <dbReference type="eggNOG" id="KOG2394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016971_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GS72"/>
    <dbReference type="OMA" id="MCVCWSP"/>
    <dbReference type="OrthoDB" id="3367at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045013">
        <property type="term" value="P:carbon catabolite repression of transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF16">
        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="327"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ85168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="541" mass="58937" checksum="94A2CEE88D5B8A4F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSN6</accession>
    <name>Q2GSN6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226945.1">
        <property type="nucleotide sequence ID" value="XM_001226944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSN6"/>
    <dbReference type="GeneID" id="4394994"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09018"/>
    <dbReference type="HOGENOM" id="CLU_1111264_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSN6"/>
    <dbReference type="OrthoDB" id="4590459at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="250" mass="28693" checksum="69F99F5D8E00DAE8" modified="2006-03-21" version="1">MADEWGRRASLMTSRKPSSGAAFSESRQHVERKGRQYIDAPDSPIQAVLILKLQYPGLQKAWVSLRVADNSSGYWSQYHQVYYDDGLDQQPLGQVDLYLSDFVGGTGLPALYCRPSVAESLAGITRNPMISITYERLRVIFLRAVHRHNPAKFTATLEDMETSFLKVVRDRAEAERRRVEAERRRVETERRRVEAEQRKVEAEQRKVEAEQRRVEAEQRVPNQLGVEGRDSLEVNLLAGQEIPGHLVDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GT60</accession>
    <name>Q2GT60_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_08844</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226771.1">
        <property type="nucleotide sequence ID" value="XM_001226770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GT60"/>
    <dbReference type="GeneID" id="4395783"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08844"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1061744_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GT60"/>
    <dbReference type="OrthoDB" id="5396311at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="149"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ84830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="262" mass="28933" checksum="18DE60970A76D3D3" modified="2006-03-21" version="1">MGLSHGEMVPPSLSDSDDMTRGRIQEWMIGSKAAVTCECRLSERDVGPRRKPGVCTLPAPRRPKPHIWPGASGTASKCNTPLLLPNFGGQAPLTAIIIRPKMAYTEDNMQKALHKFNQGGHSLRGVAHEFGIPRSTLRNRLDGHRPRSVAFERLQILSRSQEVRLCQWVSAQVDLGVPPTQVQIQEFACRILKAQGDSRVVGKNWINRFMARHSIVVVLSAKARKADEVDAGHDKEASVEEDESETSGSEDSSSIVARSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTJ7</accession>
    <name>Q2GTJ7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_08707</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226634.1">
        <property type="nucleotide sequence ID" value="XM_001226633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTJ7"/>
    <dbReference type="SMR" id="Q2GTJ7"/>
    <dbReference type="FunCoup" id="Q2GTJ7">
        <property type="interactions" value="562"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GTJ7"/>
    <dbReference type="GeneID" id="4394886"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08707"/>
    <dbReference type="eggNOG" id="KOG1919">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_12_4_1"/>
    <dbReference type="InParanoid" id="Q2GTJ7"/>
    <dbReference type="OMA" id="QTYCKGR"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="5">
        <location>
            <begin position="142"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="273"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ84693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="475" mass="52277" checksum="54F2807E0B525F78" modified="2006-03-21" version="1">MAASVTRLAGSGAPQQTQDNPVPGGSASGPVLPSPILSEPWPRPYYFEDGLRRVSPYFYTYNTWCKERWRGRQLIEVFQSEFRDRPLEYYREAMESGLVAVNGKTVGPHHILKNGHLISHTTHRHEPPVTSDPIGIIHEDDDMIVINKPSGVPVHPAGRYNYNSIVEIMKAERGLDFTPRPCNRLDRLTSGIMFIAKHTKAAEQLGVQIFQRSVRKEYVARVIGKFPDGEVVCDQPILQISPKLGLNRVRANGKAARTVFKRLAYYPPASGLAVSPNDGGTTGPAEEPVSGRSESAPRPTGGRKADEGYSIVRCLPVTGRTHQLRVHLQFLGHPIQNDPIYANQKVWGLGLGCNDAEGTLNTDEDVVTRLSRMGKDQVADAVAYYDEMVDDYYKKKAEKMSGEVCTVCSTPLYTDPGDQELALWLHSLRYEDAEGAWSYVSPLPNWALPPEGASGPTQVGGMEDLVGAAGDAIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU83</accession>
    <name>Q2GU83_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">UEV domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_08471</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226398.1">
        <property type="nucleotide sequence ID" value="XM_001226397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GU83"/>
    <dbReference type="STRING" id="306901.Q2GU83"/>
    <dbReference type="GeneID" id="4395513"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08471"/>
    <dbReference type="eggNOG" id="KOG2391">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017548_2_1_1"/>
    <dbReference type="InParanoid" id="Q2GU83"/>
    <dbReference type="OMA" id="YMNFPQP"/>
    <dbReference type="OrthoDB" id="306304at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UEV" evidence="10">
        <location>
            <begin position="47"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="SB" evidence="9">
        <location>
            <begin position="510"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="177"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ84457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="577" mass="62662" checksum="28285AD2A06C0D56" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUD1</accession>
    <name>Q2GUD1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Guanine nucleotide-binding protein beta subunit-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_08423</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226350.1">
        <property type="nucleotide sequence ID" value="XM_001226349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUD1"/>
    <dbReference type="FunCoup" id="Q2GUD1">
        <property type="interactions" value="1181"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GUD1"/>
    <dbReference type="GeneID" id="4395904"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08423"/>
    <dbReference type="eggNOG" id="KOG0279">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_7_1"/>
    <dbReference type="InParanoid" id="Q2GUD1"/>
    <dbReference type="OMA" id="NCKLKIN"/>
    <dbReference type="OrthoDB" id="7875889at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030546">
        <property type="term" value="F:signaling receptor activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="P:mRNA destabilization"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of cell integrity MAPK cascade"/>
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    </dbReference>
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        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:2001125">
        <property type="term" value="P:negative regulation of translational frameshifting"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of autophagy"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031139">
        <property type="term" value="P:positive regulation of conjugation with cellular fusion"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:regulation of amino acid metabolic process"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000765">
        <property type="term" value="P:regulation of cytoplasmic translation"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141014">
        <property type="term" value="P:ribosome hibernation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000039">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit beta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RACK1-like"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
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        <property type="entry name" value="WD40_repeat_CS"/>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="11"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="144"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="288"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ84409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="316" mass="35121" checksum="7DFB06AC554F51CF" modified="2006-03-21" version="1">MAEQLILKGTLEGHNGWVTSLATSMENPNMLLSASRDKTLIIWNLTRDETQYGYPKRSLHGHSHIVSDCVISSDGAYALSASWDKTLRLWELSTGTTTRRFVGHTNDVLSVSFSADNRQIVSGSRDRSIKLWNTLGDCKFTITDKGHTEWVSCVRFSPNPQNPVIVSSGWDKLVKVWELSSCKLQTDHIGHTGYINTVTISPDGSLCASGGKDGTTMLWDLNESKHLYSLNANDEIHALVFSPNRYWLCAATASSIIIFDLEKKSKVDELKPEFQNVGKKSREPECVSLAWSADGQTLFAGYTDNIIRAWGVMSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV45</accession>
    <name>Q2GV45_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225815.1">
        <property type="nucleotide sequence ID" value="XM_001225814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV45"/>
    <dbReference type="GeneID" id="4393539"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08159"/>
    <dbReference type="eggNOG" id="ENOG502RKP5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_449761_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GV45"/>
    <dbReference type="OrthoDB" id="4584932at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="607" mass="66728" checksum="B7E687468F892EBB" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV89</accession>
    <name>Q2GV89_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_08115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225771.1">
        <property type="nucleotide sequence ID" value="XM_001225770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV89"/>
    <dbReference type="GeneID" id="4394299"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08115"/>
    <dbReference type="HOGENOM" id="CLU_2830991_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GV89"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ86862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="66" mass="7752" checksum="AC381238E5456DDA" modified="2006-03-21" version="1">MALLRCCLRVHLHDDFQHPTYFVGGRALGKTLLIFVENCNLDYNIWPLQVCVCCSIHLWRFPYRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVB0</accession>
    <name>Q2GVB0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_08094</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225750.1">
        <property type="nucleotide sequence ID" value="XM_001225749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVB0"/>
    <dbReference type="STRING" id="306901.Q2GVB0"/>
    <dbReference type="GeneID" id="4394569"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08094"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_479790_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GVB0"/>
    <dbReference type="OMA" id="CSARNND"/>
    <dbReference type="OrthoDB" id="25896at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="217"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ86841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="568" mass="60664" checksum="3D28BA6FD3E70EBB" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVM1</accession>
    <name>Q2GVM1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225639.1">
        <property type="nucleotide sequence ID" value="XM_001225638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVM1"/>
    <dbReference type="GeneID" id="4393580"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07983"/>
    <dbReference type="HOGENOM" id="CLU_1354451_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GVM1"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="202" mass="21525" checksum="56028098E7D4CA66" modified="2006-03-21" version="1">MSSAASPVAGGGSATTKQSGTAIVVNDELVSYPARPVSQSNYELKEYASPAYTTPVDQGVGVEHVDNNNDDSCSDVDSLFGDISNMNEYFENALENESNGNGNSLPEDSDHTTSGSEQPIPVTHDFLTSPTTIDESTNAVTDPHEEFHDNDRVSNSAITVNQATIGNGDHHSGTIPTNSFNNNILFGPELQKALFNKRRGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVQ5</accession>
    <name>Q2GVQ5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_07949</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225605.1">
        <property type="nucleotide sequence ID" value="XM_001225604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVQ5"/>
    <dbReference type="FunCoup" id="Q2GVQ5">
        <property type="interactions" value="1141"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GVQ5"/>
    <dbReference type="GeneID" id="4394580"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07949"/>
    <dbReference type="eggNOG" id="KOG0364">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_1"/>
    <dbReference type="InParanoid" id="Q2GVQ5"/>
    <dbReference type="OMA" id="CGGSTIR"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03337">
        <property type="entry name" value="TCP1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000037">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000023">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000005">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012719">
        <property type="entry name" value="Chap_CCT_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02344">
        <property type="entry name" value="chap_CCT_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ86696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="540" mass="59341" checksum="08DD0824DF282682" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GW29</accession>
    <name>Q2GW29_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Translation initiation factor 3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_07825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IF-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225481.1">
        <property type="nucleotide sequence ID" value="XM_001225480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GW29"/>
    <dbReference type="STRING" id="306901.Q2GW29"/>
    <dbReference type="GeneID" id="4393664"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07825"/>
    <dbReference type="eggNOG" id="ENOG502QWD8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062478_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GW29"/>
    <dbReference type="OMA" id="INWAIAP"/>
    <dbReference type="OrthoDB" id="21573at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="entry name" value="Translation initiation factor 3 (IF-3), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938:SF0">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="Translation initiation factor IF3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ86572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="34097" checksum="E555E87212513875" modified="2006-03-21" version="1">MRASQCLFNPATALCKLFISNAAALENPRQLQRLLLPSRTVPIQLFSPSSQRHFSVYHARMLNSYQLHRREKIATEKAASRGTMRDYDIVFPWIQLRQPDGSLSPPQRTHLVLKDLNLELDTLILLATPRPDDLTPGPEYPICRIADRKAELAAEAERLAMRKSTPKITTKKLEINWAIAPHDLRLRMARLKEFLGKGFQVQVTLRHPKLRRKKRADHDQSKVVLKQVESVVSEVPGAKETKPREGTLGEMLVLLLQVPPSKLGNAPTETAPAATEEAPAEGKAEAETTPSPVQRPVAEDIRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWJ1</accession>
    <name>Q2GWJ1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225319.1">
        <property type="nucleotide sequence ID" value="XM_001225318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWJ1"/>
    <dbReference type="GeneID" id="4393894"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07663"/>
    <dbReference type="HOGENOM" id="CLU_639348_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWJ1"/>
    <dbReference type="OrthoDB" id="4177740at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="429" mass="49395" checksum="102F1EB1AC5B7C99" modified="2006-03-21" version="1">MASPIISELRVLERREFRLRLVDRFEQMLETVLSGSLAEPRIFDRELEALSTRKLLPLDIDEDQPLDLEPYHCQKFDRKRWCGDTSCADFRMNWFIEAVGRYRRGLMPKTAWALGRQCMDSDCPYYHESLGDGKFVTWNDHHVEDNLKPHVMMAVKYPYPIPGGLGPMLRAEVASAIHCILYQLRHGLFVHHRILPVLLRTYYHDRGARITQAHWDGNYLIIRQSRVLDFHAPEPTDDAYLLIEPHAMALVIKQFVDEKYATAAPQLLEKGAWEDFDHYRRLVGNSDPDIRIQGQFASAKVDQNHVLTDAYGGNGFTNRREELAVGDTHEETPSRRAIVNKAMAGFSSILTRPFTKEFTRAPDSPSKAQIEPEPSYDLIRTGLARWTIEKNIFHIKERRRNNDSQQTLADTSVQSANKPNRTEKGLAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWJ4</accession>
    <name>Q2GWJ4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225316.1">
        <property type="nucleotide sequence ID" value="XM_001225315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWJ4"/>
    <dbReference type="GeneID" id="4393891"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07660"/>
    <dbReference type="HOGENOM" id="CLU_980059_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWJ4"/>
    <dbReference type="OrthoDB" id="5419802at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="284" mass="29342" checksum="473452CD85CCEA37" modified="2006-03-21" version="1">MDNSTTGNKPAARKTAASTTTASATATSATATSTSGTRTGTRTTGTGTTGTAANTNAAKPTPRIINVGPPGAQITAAEPRPTPTPSPPAGMSSATLENIVGRLATALGDKSYAIIGTAANSLLGIGPVGSSVDVLVPTGTPSRRAEKLCTSRTTTRFKFVTNKGVFYTRGDGGKEIPITFWEPKEVNQQCPETMTDIVMVGNVRVLKPTLLLNIHCHNWLKSQSGPGKSSGNAAAHSIDLLLRHIAKETKKEVSNATGEFLVKFAAAKPEAHAGFRDLGILGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWK0</accession>
    <name>Q2GWK0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225310.1">
        <property type="nucleotide sequence ID" value="XM_001225309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWK0"/>
    <dbReference type="GeneID" id="4393920"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07654"/>
    <dbReference type="HOGENOM" id="CLU_1864898_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWK0"/>
    <dbReference type="OrthoDB" id="10573580at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="137" mass="14772" checksum="81BC41C38C9AFC05" modified="2006-03-21" version="1">MLPVSVHRLGHAWAGLVGKVCGSSPTTPVMHVGRRGPILRGMGKEMHAKKQIVLVLLFLSPALHLGWVNSRAQNGVVSPARARPRDASLPDTETRGPVISCLQRNGDEKRFLHERTLLGPARPVPIPPAAPHETGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWL5</accession>
    <name>Q2GWL5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_07639</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225295.1">
        <property type="nucleotide sequence ID" value="XM_001225294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWL5"/>
    <dbReference type="GeneID" id="4394148"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07639"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001248_0_2_1"/>
    <dbReference type="InParanoid" id="Q2GWL5"/>
    <dbReference type="OMA" id="SHMRGKE"/>
    <dbReference type="OrthoDB" id="5095382at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="159"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="666"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ86386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="696" mass="76942" checksum="93BBEF5D5E18573E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWV2</accession>
    <name>Q2GWV2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Pel9A-like right handed beta-helix region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_07552</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the polysaccharide lyase 9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225208.1">
        <property type="nucleotide sequence ID" value="XM_001225207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWV2"/>
    <dbReference type="STRING" id="306901.Q2GWV2"/>
    <dbReference type="GeneID" id="4393273"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07552"/>
    <dbReference type="eggNOG" id="ENOG502QSUT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030634_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GWV2"/>
    <dbReference type="OMA" id="ERNTAWN"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016837">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on polysaccharides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053868">
        <property type="entry name" value="Pel9A-like_beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052052">
        <property type="entry name" value="Polysaccharide_Lyase_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40088">
        <property type="entry name" value="PECTATE LYASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40088:SF1">
        <property type="entry name" value="PECTATE LYASE PEL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22842">
        <property type="entry name" value="Pel9A-like_beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209088" description="Pel9A-like right handed beta-helix region domain-containing protein" evidence="10">
        <location>
            <begin position="20"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Pel9A-like right handed beta-helix region" evidence="11">
        <location>
            <begin position="140"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="339"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ86299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="390" mass="41599" checksum="B71FB91F07CE5C50" modified="2006-03-21" version="1">MRVSQILGLALSLLGGATAKDIYVSPTGNGSGTLESPYGSIQTAVNAAAAGDTIFLRGGTYAPSANIQVGKSGTRTKPIAVRPYQNEKVIIDGDNMPGTPKELNEALPNAERGIFHIQKAEYWAFYNLELINGPYGIYARDASHNYYEGLSTHDNYETGFQLEGASANNTVLNLDSYRNRDPRKNGESADGFACKSGSGEGNVLRNARLWDNVDDGLDLFMFGSPVVMEEVYAWGNGYNRWGFTPFEGDGNGFKLGITDNPPANHVVRNCMAFANMKKGFIDNGNPGSLTMERNTAWNNGDLGFHMRSSSSTLRSNIAVANVGSAQVSLISSVSASGNSWQSGSWSNSSFASRDPATLKGARGSNGKVKPSDFLLPTSGVAIGASTQQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWZ8</accession>
    <name>Q2GWZ8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_07506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225162.1">
        <property type="nucleotide sequence ID" value="XM_001225161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWZ8"/>
    <dbReference type="GeneID" id="4394396"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07506"/>
    <dbReference type="eggNOG" id="ENOG502SPYW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2305765_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWZ8"/>
    <dbReference type="OrthoDB" id="4576493at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ86253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="100" mass="11380" checksum="A5A088F8EBFD9AB9" modified="2006-03-21" version="1">MAARRHIAVIPSDVRHTPGEVPTEPFGIGNEDFNAGLKESKYGYPVLELYELVKPVTLAEMKSSWGMGGAPMGWRYLKAGLWEDRWGTEERRDEKVKKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX56</accession>
    <name>Q2GX56_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_07448</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWI5/SAE3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225104.1">
        <property type="nucleotide sequence ID" value="XM_001225103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX56"/>
    <dbReference type="GeneID" id="4393796"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07448"/>
    <dbReference type="eggNOG" id="KOG2868">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_381294_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GX56"/>
    <dbReference type="OrthoDB" id="255837at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032798">
        <property type="term" value="C:Swi5-Sfr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034974">
        <property type="term" value="C:Swi5-Swi2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010772">
        <property type="term" value="P:meiotic DNA recombinase assembly involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010760">
        <property type="entry name" value="DNA-repair_Swi5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07061">
        <property type="entry name" value="Swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="222"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ86195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="726" mass="81051" checksum="CD21675343162EAA" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXE5</accession>
    <name>Q2GXE5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_07359</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225015.1">
        <property type="nucleotide sequence ID" value="XM_001225014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXE5"/>
    <dbReference type="STRING" id="306901.Q2GXE5"/>
    <dbReference type="GeneID" id="4393557"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07359"/>
    <dbReference type="eggNOG" id="KOG0239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_12_1_1"/>
    <dbReference type="InParanoid" id="Q2GXE5"/>
    <dbReference type="OMA" id="MCRVRPP"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01366">
        <property type="entry name" value="KISc_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000065">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF45">
        <property type="entry name" value="PROTEIN CLARET SEGREGATIONAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="628"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="228"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="377"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="474"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="719"/>
            <end position="726"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ86106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="980" mass="109623" checksum="38392B988D9BBDB4" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXF8</accession>
    <name>Q2GXF8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225002.1">
        <property type="nucleotide sequence ID" value="XM_001225001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXF8"/>
    <dbReference type="STRING" id="306901.Q2GXF8"/>
    <dbReference type="GeneID" id="4393804"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07346"/>
    <dbReference type="eggNOG" id="KOG0586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_698294_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GXF8"/>
    <dbReference type="OrthoDB" id="410920at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="395" mass="42297" checksum="58C6B5A9A61DE7E1" modified="2006-03-21" version="1">MAEIFLRQTSSSLHAESVPHNLPAAKSLEDRPDAAWWCSKDRPQARRNLHGITTCKQRLTAIKYKYRTEPADNRPTDINPQTTLTTHDPRVSCGTVVKSRFVQHPPVLRRPRRGLNTRPTPHPCHPHYPGSGPLNRTCAQAMISTPLSSLSSDRSDKPSGHNAHLVDTSAAVVAVPGPRQPAAAPQKDSDKWMSLRPVSRTPSLKAGIYGPFGSASAASSTVASPIIAAMGDLTPFPSPLLAGDSPGPWKQLGRRMSREAAMSPPASGPLDTNDQNHVSGYAKKGYAGLTSGPAPADGANPHQNGRLAQPPLHHTRNRSVSEYIPDPMLIPKRMSTVSGTRVNQDLKSAGEGHLRREPHLSEARGLTPIEKPPTPPPSESSLSTTDLALPAASGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXQ1</accession>
    <name>Q2GXQ1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_07253</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224909.1">
        <property type="nucleotide sequence ID" value="XM_001224908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXQ1"/>
    <dbReference type="FunCoup" id="Q2GXQ1">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GXQ1"/>
    <dbReference type="GeneID" id="4394177"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07253"/>
    <dbReference type="eggNOG" id="KOG1693">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066963_4_2_1"/>
    <dbReference type="InParanoid" id="Q2GXQ1"/>
    <dbReference type="OMA" id="VGEYTFC"/>
    <dbReference type="OrthoDB" id="1929172at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208715" description="GOLD domain-containing protein" evidence="10">
        <location>
            <begin position="22"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="32"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
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    </evidence>
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</entry>
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                <person name="Untereiner W.A."/>
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    </dbReference>
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    </dbReference>
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        </location>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYH8</accession>
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                <person name="Untereiner W.A."/>
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        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="936"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="964" mass="101666" checksum="D9B257E1E76F1347" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYI2</accession>
    <name>Q2GYI2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_06972</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224628.1">
        <property type="nucleotide sequence ID" value="XM_001224627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYI2"/>
    <dbReference type="FunCoup" id="Q2GYI2">
        <property type="interactions" value="869"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GYI2"/>
    <dbReference type="GeneID" id="4393869"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06972"/>
    <dbReference type="eggNOG" id="KOG0857">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084051_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYI2"/>
    <dbReference type="OMA" id="HHVIREN"/>
    <dbReference type="OrthoDB" id="10258869at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.300:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00279">
        <property type="entry name" value="uL16_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ85719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="219" mass="25151" checksum="09836AD35D7D4E80" modified="2006-03-21" version="1">MARRPARCYRYCKNKPYPKSRFNRGVPDPKIRIFDLGRKRATVDDFPLCIHLVSNEYEQLSSEALEAARICANKYLVKTAGKEGFHLRVRAHPYHVVRINKMLSCAGADRLQTGMRGAWGKPNGTVARVNIGQILMSVRTRDTNRAFALEALRRSQYKFPGRQKIIISKNWGFTPLRREEYLEKKAAGRVKVDGAYVQFLSNRGNLENNMKRFPDAFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYQ9</accession>
    <name>Q2GYQ9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_06895</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224551.1">
        <property type="nucleotide sequence ID" value="XM_001224550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYQ9"/>
    <dbReference type="STRING" id="306901.Q2GYQ9"/>
    <dbReference type="GeneID" id="4393219"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06895"/>
    <dbReference type="eggNOG" id="ENOG502SJNZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031730_4_1_1"/>
    <dbReference type="InParanoid" id="Q2GYQ9"/>
    <dbReference type="OMA" id="AHYIFNI"/>
    <dbReference type="OrthoDB" id="3496539at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF2">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209126" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="17"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="17"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ85642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="232" mass="25277" checksum="3C2FB34D93D09F86" modified="2006-03-21" version="1">MKSFFVAAALAASAEAHYIFNILMVNDQRMGGEYTYVRRNSNSYMPTFPDIVTSNDLRCNVGAKPGGGVQTATVKAGDKIGFKLFNNEFIEHPGPGFVYMSLAPNGVANYDGSGDWFKVYETGLCRGNAASDGNWCSYNKDRLEFVIPPKTPPGEYLVRVEHIGLHEGFKNRAQFYMECAQLKITGPGGGTPGPLAKIPGIYKASDPGIAYDKWKSNPAPYQMPGPAVWNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZ16</accession>
    <name>Q2GZ16_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor SWI6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_05230</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Transcription factor that plays a role downstream of the MCK1-MKK2-MPS1 cascade. Required for hyphal morphogenesis and pathogenicity. Is an important oxidative stress response regulator and plays a positive role in the regulation of extracellular peroxidases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224444.1">
        <property type="nucleotide sequence ID" value="XM_001224443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZ16"/>
    <dbReference type="FunCoup" id="Q2GZ16">
        <property type="interactions" value="386"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GZ16"/>
    <dbReference type="GeneID" id="4393105"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05230"/>
    <dbReference type="eggNOG" id="ENOG502QPWC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009666_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GZ16"/>
    <dbReference type="OMA" id="HHIAMMA"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000001">
        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000365">
        <property type="entry name" value="Start control protein cdc10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF3">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0183">Conidiation</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="12">
        <location>
            <begin position="13"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="351"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="491"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="171"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="527"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="678"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="600"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="680"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00059984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ88611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="798" mass="87874" checksum="FF1A0E28AFD2FAC8" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZA6</accession>
    <name>Q2GZA6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224354.1">
        <property type="nucleotide sequence ID" value="XM_001224353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZA6"/>
    <dbReference type="GeneID" id="4392215"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05140"/>
    <dbReference type="HOGENOM" id="CLU_1677668_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZA6"/>
    <dbReference type="OrthoDB" id="10331510at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="157" mass="17995" checksum="8653ABB6F6760AC4" modified="2006-03-21" version="1">MSSPKEHPLACPEVIRWLVDSQCISEEDLLELARTNKAISKLVLQESMRNKIKNIPFKDPDNPIHQAIMVDRPNLLQEALDLGEFEPREQAMTSPNGRRLMDETAHDLFERPLTAVQNRAPSRHRQAPSPISHLPAPQRRQQQPQPQHPVISVLRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H081</accession>
    <name>Q2H081_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224029.1">
        <property type="nucleotide sequence ID" value="XM_001224028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H081"/>
    <dbReference type="FunCoup" id="Q2H081">
        <property type="interactions" value="743"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H081"/>
    <dbReference type="GeneID" id="4392927"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04815"/>
    <dbReference type="eggNOG" id="KOG1439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021695_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H081"/>
    <dbReference type="OMA" id="AHMVCAK"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000001">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="467" mass="51688" checksum="34EE923579BC3797" modified="2006-03-21" version="1">MADEIAPEYDVIVLGTGLTECILSGVLSVKGKKVLHIDRNDHYGGCVHRFSMISPSLQKYGNYAQGTEPWKQYGRLNDWNIDLVPKFLMSSGELTNILVSTDVTRYLEFKQVAGSYVQQGAGSKATVAKVPSDAAEALRSPLMGIFEKRRMKSFIEWVGSFEPKDPSTHKGLDMSTCTMKEVYDKFGLEATTKDFAGHAMALYQTDSYLDVKGGAPEAIERLRLYGNSVARYGKSPYIYPLYGLGELPQGFARLSAIYGGTYMLNTSVEELVYEGDKAVGIKATMRGVDPEMEFETKAKTIIGDPSYFPNKVRVVGHVLRAICILKHPLASTNDSDSCQIIIPQSQVGRKNDIYIACVSSAHNVCPKGYWIAIVSTIAETTANHHLELAPGIERLGRIEEQFMGPPIPLYEPLEDGTKDNLFISKSYDASSHFETTTDDVQDIYRRVAGEKLVVKGLREGIQVTKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H088</accession>
    <name>Q2H088_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_04808</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224022.1">
        <property type="nucleotide sequence ID" value="XM_001224021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H088"/>
    <dbReference type="STRING" id="306901.Q2H088"/>
    <dbReference type="GeneID" id="4392984"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04808"/>
    <dbReference type="eggNOG" id="ENOG502QT9U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_513006_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H088"/>
    <dbReference type="OMA" id="HEDTTHV"/>
    <dbReference type="OrthoDB" id="5391043at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF23">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208793" description="Transcription factor domain-containing protein" evidence="8">
        <location>
            <begin position="24"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="226"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="447"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ88189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="54790" checksum="016C6AE8FB4026DE" modified="2006-03-21" version="1">MAFNHPALMQAMLALGSLQMAKLQGAPPTAAMKHYHLSLRRTAKNYQSPHRRTQPATLAATLLLGFYEVWNSDHDKWCKHMWGARAIIRDIPLRRLTREVLDYKRRQKEQMLRNHQCNEVCFASHGDLSVDPGAVDTELIFQITGQKVDYDLAQGHVIGGSSRPSRVTERDVETYEQIRDLYWWYCKMDVYQSFLGGTRPFYGSFDLSLLLLGRVADFASRDLARKRKARKAQGPGPSQGPPSMGPGGGGPPPGQGPGPGPGFGRGQSPPSFPGLMPTSGRVTIPRGFSPPRDPTPPSDSAEDIDLDVSTADAMREWEEIRQAFEVFRARLGPDFEPLGHDVVSPEMTPFGPALIYRTYSIAGIWMTYYMGLIVLHRAHPSMPPVAVIAAGMAAQQTGQWANEIARICAGLHEDTTHVTTTSTLVGAAFIESCFPLFVAGVQWGRSPGGNPGGKIPNGANPGGTRGRRLGVDPPTTTRPNWARCSRTPCGNGRAASTAAIPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0D5</accession>
    <name>Q2H0D5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial inner membrane protease subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_04761</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S26 family. IMP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223975.1">
        <property type="nucleotide sequence ID" value="XM_001223974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0D5"/>
    <dbReference type="STRING" id="306901.Q2H0D5"/>
    <dbReference type="GeneID" id="4391998"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04761"/>
    <dbReference type="eggNOG" id="KOG1568">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028723_4_1_1"/>
    <dbReference type="InParanoid" id="Q2H0D5"/>
    <dbReference type="OMA" id="HYEHAVV"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037730">
        <property type="entry name" value="IMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041:SF2">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peptidase S26" evidence="11">
        <location>
            <begin position="88"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ88142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="151" mass="16917" checksum="877A60DF851030F6" modified="2006-03-21" version="1">MAARWAWGSVAGGGAARRSKFLGQVSDYLIRYATWIPPLIWFNEYVAQVTSIHGPSISPHDPNKTTVKRIIGLPGDVIKTKPPYHYEHAVVPEGHIWVEGDGDKSLDSNHYGPISARLVTGRVTHILSPWERAGRVRWWEHPLRTGVHRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0R1</accession>
    <name>Q2H0R1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223849.1">
        <property type="nucleotide sequence ID" value="XM_001223848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0R1"/>
    <dbReference type="STRING" id="306901.Q2H0R1"/>
    <dbReference type="GeneID" id="4392547"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04635"/>
    <dbReference type="eggNOG" id="KOG1150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070940_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H0R1"/>
    <dbReference type="OMA" id="EIVNKAW"/>
    <dbReference type="OrthoDB" id="342454at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620:SF1">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="44"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="224" mass="26395" checksum="6CEF01CB79A419B0" modified="2006-03-21" version="1">MATQDATDDTPVDSRDALEVLESEAKEWEKDAEIDRILKAFRLDAYAVLGLKPGVPESDIKVTYRKKSLLIHPDKTKNPLAPDAFDRLKKAQTELMDEKHRAVLDEAIADARMLLMRENKWTVDSPELKTADFERKWADKTKFVLIENEHRRRRQMKAQMQEEGREQRRQDEETEQRRKKRQHEEDWEATRDQRISSWRQFQKGGKSGEEGPEKKKKKKLKPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1P7</accession>
    <name>Q2H1P7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223513.1">
        <property type="nucleotide sequence ID" value="XM_001223512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1P7"/>
    <dbReference type="GeneID" id="4393022"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04299"/>
    <dbReference type="HOGENOM" id="CLU_1686354_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H1P7"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="156" mass="17803" checksum="68B67210069EAA4A" modified="2006-03-21" version="1">MTGRKRKQEEEEELVSLPSGDEEEEEYVEDEDEDELDDEEEEEEEFSEEGEGAEGDEENEENAVPGRPPGRRSDPQERPPPANGHGRGLRRPRVRRRKSLMKKMRKTRRPKARRTKRRKMMPRKEEVPTKGVGKVAAHVAAKADAKAVAAGSDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H241</accession>
    <name>Q2H241_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prion-inhibition and propagation HeLo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_04155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223369.1">
        <property type="nucleotide sequence ID" value="XM_001223368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H241"/>
    <dbReference type="GeneID" id="4393056"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04155"/>
    <dbReference type="HOGENOM" id="CLU_529956_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H241"/>
    <dbReference type="OrthoDB" id="1911848at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ87536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="57740" checksum="5121621BDBC94721" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2U4</accession>
    <name>Q2H2U4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_03902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223116.1">
        <property type="nucleotide sequence ID" value="XM_001223115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2U4"/>
    <dbReference type="GeneID" id="4391542"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03902"/>
    <dbReference type="eggNOG" id="ENOG502RVSP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_392315_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2U4"/>
    <dbReference type="OrthoDB" id="5372708at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ87283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="703" mass="78758" checksum="3D256D8D5BEBDECB" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H399</accession>
    <name>Q2H399_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222961.1">
        <property type="nucleotide sequence ID" value="XM_001222960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H399"/>
    <dbReference type="GeneID" id="4392730"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03747"/>
    <dbReference type="eggNOG" id="ENOG502RMVP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1038942_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H399"/>
    <dbReference type="OrthoDB" id="4568644at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="224" mass="26036" checksum="CC7E39CF52B69B20" modified="2006-03-21" version="1">MATSQNPFLDSSPEMDMADEPLPPPDHVLRLIPPFNHHGEHKCGHHRHNLKEENFAKYVRRFGDDTESATWKVACRNCHSRVTLNQIHDLPCGDLICRGCLMVRAFNVKLNIERHHKRIQAVREKREDLETRFIESQDITPQDRQKFIQDHDDIRRVMFRLAGLMCCGVDMQLGRFLGCMTPAASRDLWLAIQWVGDPRYRQRICGWPDCGAVPVLSFRELLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3E9</accession>
    <name>Q2H3E9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_06816</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222911.1">
        <property type="nucleotide sequence ID" value="XM_001222910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3E9"/>
    <dbReference type="STRING" id="306901.Q2H3E9"/>
    <dbReference type="GeneID" id="4391325"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06816"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_431465_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3E9"/>
    <dbReference type="OrthoDB" id="4369586at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ90197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="634" mass="71262" checksum="1C8578D14BF2BBAA" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4M5</accession>
    <name>Q2H4M5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222485.1">
        <property type="nucleotide sequence ID" value="XM_001222484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4M5"/>
    <dbReference type="GeneID" id="4390105"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06390"/>
    <dbReference type="eggNOG" id="ENOG502T4DN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_710146_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4M5"/>
    <dbReference type="OMA" id="AYWGHEV"/>
    <dbReference type="OrthoDB" id="4577899at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="477" mass="52692" checksum="6367239386713394" modified="2006-03-21" version="1">MLKPYPVDGKCPKASCKLTIRACRPVELAKLKYWFCPECRKHYNGYNIHGVEGILNYWAYKAMCGFSYCVTPGTVPGHVVFGGTLPALLGTSRIRCELLALDKAWPHTVLETKAQWLRRLERARTVTLELARTWSSRRGRIQSNDEIRVQPGLASPMSTYPFPYVRDHVLSPITEASDSVGSTTKPPLRVKTISRETPQVHLRTLAKLCGEAPSGKPSSWLGEIQGAGSSTTTLVENPLDPWASTRRETADEKFHQASVGFTQPPSRQLTEQFNQPQRNIQPNSTGPDTSGLEPLSHGSGKVSESMRNDNVPRTDFAYWGHEVWEEDPTNTSSVEPAQGSLGKESERLQADDLTNSSSAEPIQKSPRRDPGDGILNYKAFAEVTLGEVNAREVTREQKHEHEKPNMTSRFSVSVCDEDEAAERATIASISPASEDEAFSFEDPETAIPVPETKEVQGGQLPEPSRSGLVAEIGNKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4M7</accession>
    <name>Q2H4M7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_06388</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222483.1">
        <property type="nucleotide sequence ID" value="XM_001222482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4M7"/>
    <dbReference type="FunCoup" id="Q2H4M7">
        <property type="interactions" value="277"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H4M7"/>
    <dbReference type="GeneID" id="4390115"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06388"/>
    <dbReference type="eggNOG" id="KOG1383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019582_2_3_1"/>
    <dbReference type="InParanoid" id="Q2H4M7"/>
    <dbReference type="OMA" id="FIVPFTH"/>
    <dbReference type="OrthoDB" id="5152799at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.50:FF:000001">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF3">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="335"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="484"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="377"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="489"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ89769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="508" mass="56255" checksum="07B166A6BAF23FEA" modified="2006-03-21" version="1">MSLSRHVNPEDIIQHLQNLRIPAESGSSTGQTAHLTPFSTPYASQRDIPKYQIPRDGAPGDTVYEMLKDELDLDGRPNLNLASFVDTYLEDNAQRLMVENMGKNLADNDEYPAMLSISNRCVSILAHLWGVQKGEKAVGSPTVGSSEAIHLGGLAMKRRWQERRREKGLDTLKPNIIMGANAQVALLKFARYFEVEARVLPVSEKSKFCLDPDLVRENADENTIGVFVILGSTYTGHFEPVETISKILDEYQEKTGVDIPIHVDAASGGNFELPRVVSINASGYHLDPQPPFNLPPTTNNNLQAHKYGSQSYTLNFLSRPGAQVVVQYYNPHPPRLSRATARSWRTASPTRASCRKASKPPAGTPASARSTGPAPPSTNNNKPENQNETSASYTAGLPVVAFRHTDAFRAAYPHIKQETVSLLLRARQWIIPNYALPPHEDGTEILRVVIRVNMSFDLLERLVKDVVQVTERLMERDEVDLSVLHHHGGRGDGGREGEKVKGIHRSVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H542</accession>
    <name>Q2H542_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_06223</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222318.1">
        <property type="nucleotide sequence ID" value="XM_001222317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H542"/>
    <dbReference type="STRING" id="306901.Q2H542"/>
    <dbReference type="GeneID" id="4390400"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06223"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005210_4_0_1"/>
    <dbReference type="InParanoid" id="Q2H542"/>
    <dbReference type="OMA" id="GSFNHAD"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00625">
        <property type="entry name" value="RCC1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="91"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="93"/>
            <end position="508"/>
        </location>
    </feature>
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        <location>
            <begin position="146"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="223"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="276"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="333"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="397"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ89604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="518" mass="54823" checksum="3CFB8283395BA641" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H569</accession>
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        <recommendedName>
            <fullName evidence="6">Hsp70-like protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">CHGG_06196</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ89577.1"/>
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    </dbReference>
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    <dbReference type="STRING" id="306901.Q2H569"/>
    <dbReference type="GeneID" id="4390698"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
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        <location>
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            <end position="42"/>
        </location>
    </feature>
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            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ89577.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="684" mass="74849" checksum="8B0E383321B7BC00" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5D7</accession>
    <name>Q2H5D7_CHAGB</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Sordariomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
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            <authorList>
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                <person name="Untereiner W.A."/>
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                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="3360421at2759"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="92" mass="9845" checksum="0F5D758C6CC7B2A3" modified="2006-03-21" version="1">MPSGKGIPPLPGATDPKLRGHLEEGKAMIPYLGRQQEPNKSGDGKGQWAAWKGMKLAREYEAHSGSYEDDPGSENEPKTGAPVAKSESKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5F2</accession>
    <name>Q2H5F2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_06113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="347" mass="38721" checksum="0FBAB561D735A93D" modified="2006-03-21" version="1">MYAFPQSALSSKATRDITLASSYLSPGHVLEDRGTIEDIPRGPFHNEADYYSSLAIALRLHAEQLHMGHHVLRAPVPVPQEYPDFAKYYAATDRWNDLVALGGMVNPSTNRLQYCLASDLFRDSIIPRMVRPVNQSAPGFPLCHHDISVQNLFVDDDFNITCVIDWAFSSTVFPAQLFATPGLPHPRDLLLDLSLVRAFRSGIEAENKRISGGTIESSYWKTSHMVSRFMRVVNLDALQDYGHLEALYALAGGPVTSGVDGDDTNNLSATLARRATSHDALSLVSELAADDEPQSEINRREKQYFDAVGAQRLALARKVAFAAKMNPQFVADGRLWRWVYEALEYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5S2</accession>
    <name>Q2H5S2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05993</name>
    </gene>
    <organism evidence="3 4">
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222088.1">
        <property type="nucleotide sequence ID" value="XM_001222087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5S2"/>
    <dbReference type="GeneID" id="4391443"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05993"/>
    <dbReference type="eggNOG" id="KOG3798">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051050_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H5S2"/>
    <dbReference type="OMA" id="NGFNMLT"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050114">
        <property type="entry name" value="UPF0173_UPF0282_UlaG_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546:SF9">
        <property type="entry name" value="L-ASCORBATE-6-PHOSPHATE LACTONASE ULAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546">
        <property type="entry name" value="UPF0173 METAL-DEPENDENT HYDROLASE MJ1163-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="29"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="266" mass="28689" checksum="E44BEA5A0BE53F4B" modified="2006-03-21" version="1">MASNVKFNAPLAVTHIGTATAIIHVDGINLLTDPVFSPAGTEWDVGVVVLKISDTPAKGLTRLPHIDAVLLSHEDHPDNLDEPGRATLDGRHVFTTPDGAKKLAPRPDVRAIQPWETLPLDIGGKRFEITSTPCEHLPGGEVTGFIISAPSFGTTDGKPNAIYFSGDTIYLPELAKMKKRFHISVALLNIGKATVPLPTGPLAITMDGADAAKLFKELEADVLVPMHFESWGHFAEKREELAASLEKEGVMDKVLWLEPGVKMTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5W2</accession>
    <name>Q2H5W2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_05953</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat WDR3/UTP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222048.1">
        <property type="nucleotide sequence ID" value="XM_001222047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5W2"/>
    <dbReference type="FunCoup" id="Q2H5W2">
        <property type="interactions" value="1027"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H5W2"/>
    <dbReference type="GeneID" id="4390835"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05953"/>
    <dbReference type="eggNOG" id="KOG0306">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005318_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H5W2"/>
    <dbReference type="OMA" id="MNIPLTC"/>
    <dbReference type="OrthoDB" id="407922at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000157">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000178">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25173">
        <property type="entry name" value="Beta-prop_WDR3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25172">
        <property type="entry name" value="Beta-prop_WDR3_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="83"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="472"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="514"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="561"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="8">
        <location>
            <begin position="696"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ89334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="831" mass="92684" checksum="9950D77A832A2220" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H655</accession>
    <name>Q2H655_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein bL21m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_05860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221955.1">
        <property type="nucleotide sequence ID" value="XM_001221954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H655"/>
    <dbReference type="STRING" id="306901.Q2H655"/>
    <dbReference type="GeneID" id="4390300"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05860"/>
    <dbReference type="eggNOG" id="KOG0453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_379917_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H655"/>
    <dbReference type="OrthoDB" id="5994at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="bL21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="bL21-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="L21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="124"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="256"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="349"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="560"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="438"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ89241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="729" mass="80956" checksum="582CB06B20AED2D0" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-05-18" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H683</accession>
    <name>ENOPH_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enolase-phosphatase E1</fullName>
            <ecNumber evidence="1">3.1.3.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">2,3-diketo-5-methylthio-1-phosphopentane phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">UTR4</name>
        <name type="ORF">CHGG_05832</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="3.1.3.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.77" evidence="1"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221927.1">
        <property type="nucleotide sequence ID" value="XM_001221926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H683"/>
    <dbReference type="SMR" id="Q2H683"/>
    <dbReference type="FunCoup" id="Q2H683">
        <property type="interactions" value="566"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H683"/>
    <dbReference type="GeneID" id="4390056"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05832"/>
    <dbReference type="eggNOG" id="KOG2630">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023273_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H683"/>
    <dbReference type="OMA" id="LQGMVWE"/>
    <dbReference type="OrthoDB" id="272500at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00876"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00877"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043874">
        <property type="term" value="F:acireductone synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01629">
        <property type="entry name" value="HAD_EP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.720.60:FF:000007">
        <property type="entry name" value="Enolase-phosphatase E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03117">
        <property type="entry name" value="Salvage_MtnC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023943">
        <property type="entry name" value="Enolase-ppase_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027511">
        <property type="entry name" value="ENOPH1_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01691">
        <property type="entry name" value="enolase-ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371:SF1">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01133">
        <property type="entry name" value="C1.5.4:_Enolase-phosphatase_Li"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0486">Methionine biosynthesis</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000393997" description="Enolase-phosphatase E1">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="133"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03117"/>
        </source>
    </evidence>
    <sequence length="239" mass="25944" checksum="E245D642C15C15B5" modified="2006-03-21" version="1">MAAAKKPRVVLLDIEGTVCPISFVKDVLFPYALSALPSTLAQEWDAPAFARYRAAFPAEHASTPSALAAHARDLMARDVKIGYLKALQGYLWEAGYASGALRAPLFEDVAPKVREWTSAAGEEGGVARVMIYSSGSVPAQKLLFRHTSGEPADLTDAITDYFDTVNAGPKTEPASYERIAAKYPEVPAGEWLFLSDNVREVEAAREAGMRACVVQRPGNAELPEDVRGRLEVVESFEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6G5</accession>
    <name>Q2H6G5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_05750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221845.1">
        <property type="nucleotide sequence ID" value="XM_001221844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6G5"/>
    <dbReference type="GeneID" id="4391312"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05750"/>
    <dbReference type="eggNOG" id="KOG4157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016905_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H6G5"/>
    <dbReference type="OMA" id="VAECKGN"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051589">
        <property type="entry name" value="Sialate-O-sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964:SF9">
        <property type="entry name" value="SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208858" description="WSC domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="35"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="139"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="247"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ89131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="565" mass="60841" checksum="D1AC925B16EE631E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6N3</accession>
    <name>Q2H6N3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_05682</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221777.1">
        <property type="nucleotide sequence ID" value="XM_001221776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6N3"/>
    <dbReference type="FunCoup" id="Q2H6N3">
        <property type="interactions" value="481"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H6N3"/>
    <dbReference type="GeneID" id="4390368"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05682"/>
    <dbReference type="eggNOG" id="KOG0581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="InParanoid" id="Q2H6N3"/>
    <dbReference type="OMA" id="KMLEHPW"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050850">
        <property type="term" value="P:positive regulation of calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06621">
        <property type="entry name" value="PKc_Pek1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000294">
        <property type="entry name" value="Map kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000263">
        <property type="entry name" value="MAP kinase skh1/pek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINAE MKK2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
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    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="212"/>
            <end position="482"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
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        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
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        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ89063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="510" mass="55130" checksum="F6E8563F5CED59F4" modified="2006-03-21" version="1">MPSYPPLGIPQQHHTPSQVPTMSAAPPLLRPAIPGSRPGGRAPRLGLAIPPSPNAKALGNPGAPPPRPAPPTLHLATPMGSSVVPPEQKPLKPQLSLSLQSASGGSESSAAHSRSGSFGPLDGRASNPTSAGSQFSALSFASQYGIGRQTGDPVSAVGSLYSNASESMDMDREGSLHGLESFDELTLEKARAADVDDLDDEGWRIVSMEKRIIELGNLGEGAGGAVTKCKLRGGDTVFALKIITTNPDPDAKRQIIRELGFNKGCASQHICRYYGAFVDPASSTISIAMEFCEGGSLDSIYKEVKNLGGRTGEKVLGKVAEGVLHGLTYLHSKKIIHRDIKPSNILLCRNGDVKLCDFGVSGEFGTKGDASTFIGTSYYMAPERITGQSYTITSDVWSTGITLLEVAQHRFPFPADGTEMQPRATPLDLLTYIVKHPTPKLKDEPEANIYWSGSFKYFIECCLEKEPARRASPWRMLEHPWMIEMTTKRVNMRRYLAQVWGWDDKDQQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6R5</accession>
    <name>Q2H6R5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator complex subunit 15 KIX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_05650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001221744.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="4390267"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05650"/>
    <dbReference type="eggNOG" id="ENOG502S52Q">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003853_0_0_1"/>
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    <dbReference type="OMA" id="GQLKQWA"/>
    <dbReference type="OrthoDB" id="3918840at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:regulation of DNA-templated transcription"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Coactivator CBP, KIX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036529">
        <property type="entry name" value="KIX_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="242"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="611"/>
            <end position="653"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1000"/>
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        </location>
    </feature>
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        <location>
            <begin position="1061"/>
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        </location>
    </feature>
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        <location>
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            <end position="1247"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
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        <location>
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            <end position="280"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="723"/>
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        </location>
    </feature>
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        <location>
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            <end position="1011"/>
        </location>
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        <location>
            <begin position="1012"/>
            <end position="1027"/>
        </location>
    </feature>
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        <location>
            <begin position="1072"/>
            <end position="1087"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ89031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1365" mass="148516" checksum="A23939DE7DF0000C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H767</accession>
    <name>Q2H767_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_05498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001221592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H767"/>
    <dbReference type="GeneID" id="4390881"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05498"/>
    <dbReference type="HOGENOM" id="CLU_3106176_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H767"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ88879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="51" mass="5765" checksum="F41EA699BD4900A0" modified="2006-03-21" version="1">MMQRKSPVRSCGERTQRSQYHQTIIYNSAAIGWPVKREAKAELGEDAASDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7D7</accession>
    <name>Q2H7D7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tyrosinase</fullName>
            <ecNumber evidence="3">1.14.18.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_05428</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34287"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57504"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosine + O2 = L-dopaquinone + H2O</text>
            <dbReference type="Rhea" id="RHEA:18117"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosinase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.1" evidence="3"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221523.1">
        <property type="nucleotide sequence ID" value="XM_001221522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7D7"/>
    <dbReference type="STRING" id="306901.Q2H7D7"/>
    <dbReference type="GeneID" id="4390848"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05428"/>
    <dbReference type="eggNOG" id="ENOG502R1BY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013691_1_2_1"/>
    <dbReference type="InParanoid" id="Q2H7D7"/>
    <dbReference type="OMA" id="CTSVEAT"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041640">
        <property type="entry name" value="Tyrosinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF76">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18132">
        <property type="entry name" value="Tyrosinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="11">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="12">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ88809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="699" mass="79097" checksum="A85E0A399C52A93D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7G9</accession>
    <name>Q2H7G9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_05396</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221491.1">
        <property type="nucleotide sequence ID" value="XM_001221490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7G9"/>
    <dbReference type="FunCoup" id="Q2H7G9">
        <property type="interactions" value="106"/>
    </dbReference>
    <dbReference type="GeneID" id="4389981"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05396"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="InParanoid" id="Q2H7G9"/>
    <dbReference type="OMA" id="TSNRWAW"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF40">
        <property type="entry name" value="THIAMINE PATHWAY TRANSPORTER THI73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="60"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ88777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="505" mass="55375" checksum="FAED38D794EE4690" modified="2006-03-21" version="1">MSTTSDKNSAKDRVDVNETVRDGASGELDTAWKYLDANRDADTSEPIDLAALRRKIDWHIVPLMFLCYTLQFLDKVILNYANVMGLQKDLNMGGNDFSNVATFLFVGLLVFEVPNIYFLQAVPAAKWLGLNVILWGTATACGAAATSYQTLLVSRVFLGIFEATIAPSLMLISSQWYTKSEQAPRFSFWYTGLGIGQIVGGLVSYGFQHIGEGSRLAGWRIMFVVLGVVTVVVGSCVVLFLPDTPMKAKWLSSNEKVALLKHVSVNQTGIENRKFRGKEIVEALLDPQIYLLLLSVILLSVSSGVVTSYSATLIRGLQYDSKQSALMNTPSGAVSIFFTLFVGFGIRLQSHRWAFIIACIIPAIIGGALMSFLPITNRAGCLAGIYLVNAVVAPLAIFYNWTVANIGGGTKRAFAAALISGSFSLGNIIGPQTFQAKDAPEYRPAKIAVMGTQAGCALTTFLLFLYYVWQNKKRTSEGEQEEAYMSPEAWANMTDKENKKFRYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7S6</accession>
    <name>Q2H7S6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221384.1">
        <property type="nucleotide sequence ID" value="XM_001221383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7S6"/>
    <dbReference type="STRING" id="306901.Q2H7S6"/>
    <dbReference type="GeneID" id="4391361"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05289"/>
    <dbReference type="eggNOG" id="ENOG502RYBX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054818_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7S6"/>
    <dbReference type="OMA" id="CIITTRI"/>
    <dbReference type="OrthoDB" id="193478at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018750">
        <property type="entry name" value="DUF2306_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10067">
        <property type="entry name" value="DUF2306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="299" mass="32877" checksum="962D155A9F304203" modified="2006-03-21" version="1">MTTDRPPANAFVAAARKVYGPVGFTKGYNFILFFIFGGAFLGFALARLQYLALDTTCISGKDSEKPLDCYYYTERSIDRVGILLHLATILPASLLTCLQFVPIIRRTFVLFHRINGYLIVILSLVSTAGALMLARNAVGGWMDVQMAVGVLSIAFLSSLALALYNIKRLQIEQHRAWMLRAWFYHPDCEAYFSGQNPNKAVLVSATMDGNGSNATAVLSLGFGAAFWLAFAMHAVGVEIYLRLTPAEANRLRNVSYQRQLEAGMKHPGRSGLTADRIGDSALWEPKGQEHSAEKVEGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7U2</accession>
    <name>Q2H7U2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221368.1">
        <property type="nucleotide sequence ID" value="XM_001221367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7U2"/>
    <dbReference type="STRING" id="306901.Q2H7U2"/>
    <dbReference type="GeneID" id="4391273"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05273"/>
    <dbReference type="eggNOG" id="ENOG502S5JI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016574_3_0_1"/>
    <dbReference type="InParanoid" id="Q2H7U2"/>
    <dbReference type="OMA" id="MIWQLST"/>
    <dbReference type="OrthoDB" id="4132249at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="43914" checksum="596AA53D65C3A566" modified="2006-03-21" version="1">MATLPQRRSLPPASVVGYCFRRFFAELHPTIPILSPEYVELVAAEAASLGGVEAQCLITAVCAVVLIQVEEPSQHMFEADGIPHSNRKLGELLFEDAMMARNHMSSGFNPSLERVLATFFLYAGHASLFHHSQGFYFLREAATMWLVLRINEADTLRRNLADRLFWVILVSERSHGIRYRRPVTLQVTSSGPDLDGGVEADATISGLKRLVALFRPLDTVFFALLNQEDTVFLPGLLPPLEAVQVAIRGALEPRHAYVLCETQLANLKVTQLWLLVTLWQLRLRLGLLVEGPGVSGHLTFRYPVEVGEELAGVIRAMSLGSIRIHGVGINEKIFDVACAMIDVLSRVPATDKSGTGLENIGYFRGLIRELPGGVSTYGALLDKHISNTLPTLLESPGIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H875</accession>
    <name>Q2H875_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_03579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230095.1">
        <property type="nucleotide sequence ID" value="XM_001230094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H875"/>
    <dbReference type="STRING" id="306901.Q2H875"/>
    <dbReference type="GeneID" id="4389106"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03579"/>
    <dbReference type="HOGENOM" id="CLU_1677663_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H875"/>
    <dbReference type="OrthoDB" id="4953097at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ91644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17605" checksum="702D32DE23B0D317" modified="2006-03-21" version="1">MGKSYGLGFVKRRASNYINGQATRFDLYCDRGQARPSIATVHKTTTSKTGCHWRGVAKALKENNRQWTFEIANQYHNHDTSGENPAELTTHAVHRGLSDAMMKDVEALSLNPAQRPRDIVLFLQKRYPHTVFTTKDVPITGNCCNGTISTDITQLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8B3</accession>
    <name>Q2H8B3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230057.1">
        <property type="nucleotide sequence ID" value="XM_001230056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8B3"/>
    <dbReference type="GeneID" id="4388449"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03541"/>
    <dbReference type="eggNOG" id="ENOG502RIX6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089355_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8B3"/>
    <dbReference type="OMA" id="HATIHYR"/>
    <dbReference type="OrthoDB" id="4590762at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="272" mass="28708" checksum="C0D8513BFD708E4E" modified="2006-03-21" version="1">MMSFHSNQLLLIQLHATIHYRRGNAATTTAAGNPPNPFRSHKLPPVTFTANTAIPSPSYDSAITDDPLNSFDSFNPRNDTHNPGPYNRPSPRAPIDTSTPPDLFLRSIDTACLTRVRAMTQHTAYRFDRPVNYEVERAFVWAGVAGGDEWMGMGAAGLGGFGLGEGSVSGGGAGHEAGGGGDGGDGAGAGGVGAGGVGAGTASLSMRGLSSAEITQQVDMMRLRGYRDWVRVKMEVEIEPGRELRKREAAWLTGGRGQMGTSSLSESEEDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9E9</accession>
    <name>Q2H9E9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229671.1">
        <property type="nucleotide sequence ID" value="XM_001229670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9E9"/>
    <dbReference type="GeneID" id="4388924"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03155"/>
    <dbReference type="HOGENOM" id="CLU_1758584_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9E9"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="148" mass="16328" checksum="15AF674B720B28CF" modified="2006-03-21" version="1">MIWAELQAPLEDLGWMYGMVSQRGGQQFPSTSWQFGVASCALSSAMGTLIDVDFLRQWWAGVTGSDCPLSVRDTPVEDLGNTWQHAPDCIQETRREGDETVGDEIQGTRTRDYGAALREENSPHPGSRTAPGAGWLNESGKRRGKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9F0</accession>
    <name>Q2H9F0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_03154</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229670.1">
        <property type="nucleotide sequence ID" value="XM_001229669.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2H9F0">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H9F0"/>
    <dbReference type="GeneID" id="4388923"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03154"/>
    <dbReference type="eggNOG" id="ENOG502QU87">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001720_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9F0"/>
    <dbReference type="OMA" id="TKVEWLW"/>
    <dbReference type="OrthoDB" id="10070851at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd07609">
        <property type="entry name" value="BAR_SIP3_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13280">
        <property type="entry name" value="PH_SIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039463">
        <property type="entry name" value="Sip3/Lam1_BAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042067">
        <property type="entry name" value="Sip3_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14248">
        <property type="entry name" value="CYCLIN Y, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="357"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="7">
        <location>
            <begin position="941"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="560"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="872"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="568"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="881"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="914"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ91219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1362" mass="150117" checksum="2E4679E8C9690D3A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9G1</accession>
    <name>Q2H9G1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zinc finger CHCC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229659.1">
        <property type="nucleotide sequence ID" value="XM_001229658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9G1"/>
    <dbReference type="STRING" id="306901.Q2H9G1"/>
    <dbReference type="GeneID" id="4389803"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03143"/>
    <dbReference type="eggNOG" id="KOG3456">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1594328_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9G1"/>
    <dbReference type="OrthoDB" id="307899at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.40:FF:000003">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.40">
        <property type="entry name" value="q5lls5 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019401">
        <property type="entry name" value="Znf_CHCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10276">
        <property type="entry name" value="zf-CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger CHCC-type" evidence="2">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="167" mass="17846" checksum="2F18ACC6551E32A4" modified="2006-03-21" version="1">MYALTPERGVGATADRFPSPGTGTTRVSATVAAAAFSHPRPPRAQTHSQRPEPGNRPPPPAPASKYRATGRGGGDPSRPLSPSSRLIAPEPRPYAAIELIHQQPVRWTHDRIVACDGGGGPEGHPKIFINTDKPEITPCGYCGLPFANEHHRQHLESLPETSYPLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9M9</accession>
    <name>Q2H9M9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Abscisic acid G-protein coupled receptor-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_03075</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229591.1">
        <property type="nucleotide sequence ID" value="XM_001229590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9M9"/>
    <dbReference type="STRING" id="306901.Q2H9M9"/>
    <dbReference type="GeneID" id="4389058"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03075"/>
    <dbReference type="eggNOG" id="KOG2417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039213_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9M9"/>
    <dbReference type="OMA" id="YVIYITH"/>
    <dbReference type="OrthoDB" id="264392at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025969">
        <property type="entry name" value="ABA_GPCR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022535">
        <property type="entry name" value="Golgi_pH-regulator_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015672">
        <property type="entry name" value="GPHR/GTG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 89-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948:SF0">
        <property type="entry name" value="GOLGI PH REGULATOR A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12430">
        <property type="entry name" value="ABA_GPCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12537">
        <property type="entry name" value="GPHR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Golgi pH regulator conserved" evidence="7">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Abscisic acid G-protein coupled receptor-like" evidence="6">
        <location>
            <begin position="137"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ91140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="36270" checksum="46618624AE7F8C70" modified="2006-03-21" version="1">MALLSGFASVSSPWHIFVDDRTYRKRPITDANIARKQAGLDAASELLLTKRHRLRSLQRKAQAVADGAGGGTAHGASAGSGVGLVGKMLGSLKTIAGSGEAAEIRTLQVEISGLETMESNLASSLSTLRSRQAAHARDGTALGRLLAVPQYIFAGYCVYRILATTLTSLRRIYYPSASFSSSDPINRFLGVLAKHWDPKLDQIAWARQISFLLSGVILAASANSVLQTFRIFAKWAPGLFHQAQANLALLVGQVTATYVISAALLMRSNLPRDVSRTVGDALESALEPGFVDRWFEGWFLLASIGTAAGIWVGRKVNSGFGEEWDEFAGEEMGQKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HA21</accession>
    <name>Q2HA21_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine-rich PDZ-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cysteine-rich interactor of PDZ three</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_02933</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRIPT family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229449.1">
        <property type="nucleotide sequence ID" value="XM_001229448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HA21"/>
    <dbReference type="STRING" id="306901.Q2HA21"/>
    <dbReference type="GeneID" id="4388408"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02933"/>
    <dbReference type="eggNOG" id="ENOG502SR0H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133934_2_1_1"/>
    <dbReference type="InParanoid" id="Q2HA21"/>
    <dbReference type="OMA" id="KITQGHS"/>
    <dbReference type="OrthoDB" id="147332at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019367">
        <property type="entry name" value="PDZ-binding_CRIPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805:SF1">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10235">
        <property type="entry name" value="Cript"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ90998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="120" mass="12806" checksum="C6F0E774743E214B" modified="2006-03-21" version="1">MVCAKCQKLNKTTLATPGVKKKAEMYYGSAASASSSGAKKSATLGQTGISKSKLLSKAAKNPYAQYSSSCGRCKTKIAQGHTYCNQCAYRDDEIACHICGKPNKKKTAVPTVDGQKRTFK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-24" modified="2025-04-09" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HA54</accession>
    <name>PLPL_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Patatin-like phospholipase domain-containing protein CHGG_02900</fullName>
            <ecNumber>3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">CHGG_02900</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable lipid hydrolase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PLPL family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229416.1">
        <property type="nucleotide sequence ID" value="XM_001229415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HA54"/>
    <dbReference type="STRING" id="306901.Q2HA54"/>
    <dbReference type="GeneID" id="4389131"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02900"/>
    <dbReference type="eggNOG" id="KOG2214">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009031_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HA54"/>
    <dbReference type="OMA" id="CSWFTRG"/>
    <dbReference type="OrthoDB" id="15478at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07232">
        <property type="entry name" value="Pat_PLPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF66">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE PTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0442">Lipid degradation</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000295555" description="Patatin-like phospholipase domain-containing protein CHGG_02900">
        <location>
            <begin position="1"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="387"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="58"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="724"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="791"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="3">
        <location>
            <begin position="418"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="729"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="752"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="799"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="854" mass="94412" checksum="76D312484F5C204A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HA61</accession>
    <name>Q2HA61_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosome-interacting GTPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_02893</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229409.1">
        <property type="nucleotide sequence ID" value="XM_001229408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HA61"/>
    <dbReference type="FunCoup" id="Q2HA61">
        <property type="interactions" value="1115"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HA61"/>
    <dbReference type="GeneID" id="4389516"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02893"/>
    <dbReference type="eggNOG" id="KOG1487">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044997_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HA61"/>
    <dbReference type="OMA" id="SAKHPGQ"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17230">
        <property type="entry name" value="TGS_DRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="50"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="276"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ90958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="38178" checksum="67790ACB857446CB" modified="2006-03-21" version="1">MARTQKNKATSYHIGQLKAKLAKLKRELLTPSSGGGGGGAGFDVARTGVASVGFIGFPSVGKSTLMSRLTGQHSEAAAYEFTTLTSVPGQVMYNGAPLQMIDLPGIIEGAKDGRGRGRQVIAVAKTCHLIFIVLDVNKPLTDKRVIEAELEGFGIRINKGPPNITFKKKDKGGLNITSTVPLTHIDHDEIRAVMSEYKISSADIAIRCDATIDDLIDILEAKSRSYIPVIYVLNKIDSISIEELDLLYRIPNSVPISSEHGWNVDELMEAMWEKLNLVRVYTKPKGKMPDYSSPVVLRSNKCTVEDFCNSIHKTIVEQFKSAVVYGKSVKHQPQRVGLAHELADEDIGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBE6</accession>
    <name>Q2HBE6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_02458</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <subcellularLocation>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
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        <location>
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            <end position="242"/>
        </location>
    </feature>
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        <location>
            <begin position="243"/>
            <end position="284"/>
        </location>
    </feature>
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        <location>
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            <end position="326"/>
        </location>
    </feature>
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        <location>
            <begin position="347"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="422"/>
            <end position="456"/>
        </location>
    </feature>
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        <location>
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            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
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        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ90523.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="564" mass="61724" checksum="886CD36F9614CA14" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBM0</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Sordariomycetes</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209387" evidence="1">
        <location>
            <begin position="20"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="148" mass="15719" checksum="37310F1293A28EF3" modified="2006-03-21" version="1">MKYLSILAPALGLLATTSAMPLEERDDVQTVHLTFHGGPAEYSLAIPADGTIHPTNNNIAVNIIDAPDYNAYYQCQFHINGDATLASSISSTGVNQILVGPPSPITGVSCQGMCVPTYGDCYRNGQYVGPCCAGYCAANKCRPWVSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBR0</accession>
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        <recommendedName>
            <fullName evidence="6">Glycoside hydrolase family 5 domain-containing protein</fullName>
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    </gene>
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            <taxon>Sordariomycetidae</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263:SF0">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209110" description="Glycoside hydrolase family 5 domain-containing protein" evidence="5">
        <location>
            <begin position="17"/>
            <end position="425"/>
        </location>
    </feature>
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        <location>
            <begin position="59"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ90409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="425" mass="46728" checksum="FCDB40B650BEF6B5" modified="2006-03-21" version="1">MQPILALLALFSIGSAAPSLESTQDDMSKRAAWPNGPFVTSGRWIHDASGKNLTYAGTNWPGHADVMIPEGLQYQSIETIVQKVKSLGMNAVRLTFAIQMVDEIYANGGQDITIQKAFVQALGQTNGAKVLNQVLAKNPRFSATTTRLQVFDAVAGELNKQQIYVHLDNHISKGMWCCGSTDGNSWWGDTYFSTSNWVRGLSYMAEHGKSWPALTSIGLRNEPREPTNNPPLSRSSYNWQAWYGFMRQGADAVHAANPSLLIFLSGLSFDTYLTPVVQGTALTPGNGRFNRNDFAGYGDTKLVLELHNYETGIGSCATLQGNLDRNGFEALQASGAGAFPVMMTEFGFQMDASTWRGVYASCLAQYLPARKAGWAIWVLAGSYYMRSGTQDYDENWGLLNHDWSGWRSQSYVDGALKAMVRNTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBR9</accession>
    <name>Q2HBR9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PFL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_02335</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228851.1">
        <property type="nucleotide sequence ID" value="XM_001228850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBR9"/>
    <dbReference type="STRING" id="306901.Q2HBR9"/>
    <dbReference type="PeroxiBase" id="13892">
        <property type="entry name" value="CgDyPrx"/>
    </dbReference>
    <dbReference type="GeneID" id="4388416"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02335"/>
    <dbReference type="eggNOG" id="ENOG502S07F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_260897_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HBR9"/>
    <dbReference type="OMA" id="VRMGGWT"/>
    <dbReference type="OrthoDB" id="76259at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="1056"/>
        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ90400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1229" mass="135993" checksum="9AE7EE94BAEF983F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBW0</accession>
    <name>Q2HBW0_CHAGB</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ90359.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02294"/>
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    <dbReference type="Proteomes" id="UP000001056">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="388"/>
        </location>
    </feature>
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        <location>
            <begin position="469"/>
            <end position="501"/>
        </location>
    </feature>
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        <location>
            <begin position="708"/>
            <end position="748"/>
        </location>
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        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="813" mass="87363" checksum="F7A79E99F2832828" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HC50</accession>
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            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">CHGG_02204</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02204"/>
    <dbReference type="eggNOG" id="ENOG502SQ23">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035264_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HC50"/>
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    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="178"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="393" mass="44282" checksum="65C99021446817D8" modified="2006-03-21" version="1">MSVPTVKAGRILAKPIRDRINIHYESDDDCVVFIRCNGVEFQIELSPFFLCNSPLLTARYHKFIAAVRYRSGMGGEEGDSEEEEHPEDVQTQFHDWIIAVFKPIFSTVAPTVPPSFDPDMIRTGKAKPMLSEYLLPETHRCRLESENDEPIPIHMPDKESQFMEPLCHVDPDLAREAKELVKFFDPSAVEVWFQHPKQALEDTPTRVLVDLGGSGEKTTCFCKGFGAGEFIVLERELETHLRLLKSKVVPEARVVRLLGVVAVEDGRVAGLLLPYVDCRRDNDGVLDGLYLCRIPVLLRERWAGQIKEAVQQLHEGGVVWGDAKAANILIDKNDDAWLIDFGAGHTEGWVDEEKRGTKEGDLQGVEKIVEYLFSEEYNSESASSDYDFDSASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCF9</accession>
    <name>Q2HCF9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_02095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221316.1">
        <property type="nucleotide sequence ID" value="XM_001221315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCF9"/>
    <dbReference type="GeneID" id="4387264"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02095"/>
    <dbReference type="eggNOG" id="ENOG502SM9E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022448_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCF9"/>
    <dbReference type="OMA" id="VAEFWIM"/>
    <dbReference type="OrthoDB" id="5313079at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="546"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="684"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="756" mass="82566" checksum="914A4D5706F2768B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCY2</accession>
    <name>Q2HCY2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">White collar-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_01922</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221143.1">
        <property type="nucleotide sequence ID" value="XM_001221142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCY2"/>
    <dbReference type="STRING" id="306901.Q2HCY2"/>
    <dbReference type="GeneID" id="4386441"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01922"/>
    <dbReference type="eggNOG" id="KOG1601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024414_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCY2"/>
    <dbReference type="OMA" id="HTDTIEM"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051140">
        <property type="entry name" value="GATA_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658:SF18">
        <property type="entry name" value="PROTEIN GAT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="127"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="7">
        <location>
            <begin position="407"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="70"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="271"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="70"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ93687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="50671" checksum="6742929CEA1CE32C" modified="2006-03-21" version="1">MSHRRSLSSGFMGFGMPMNMGSGTSTLQMNPDPADTIFPLDSSFFYQFGDRPMSMTLDAIDPLASTFETPPGQASSAALVGSTPQSTGFSPNDTTGNDLAQESLGAGNQSQSNGLNEFTKRPNWPARVVDVLRDLLHIFDADGRIKTVSPSAVNLTGYQPTELCGLLMQDLLHPDDVGVFTAELNQSIASGNPFCVFYRMKKKDGTYAIFEAIGHAHIAAPKFAPNPNNQTAFCQAVFMMARPYPTKNAVLLDSFLEHKMENERLKRKIAELQKEEQEDTEELERTWRGSQETTPSESGARFGPSPLQPQSDASIPPREQGTSLDGGLAEGIMGPRRSSIGVTHTDTIEMLTGLRYQEGERSRGITTGVASPTLVSGDIGMITGDVGIAIPLDRDQRTGDKKKKLKMVEEYVCTDCGTLESPEWRKGPSGPKTLCNACGLRWAKREKKKSISHGGGGGPEHSGPGFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HD19</accession>
    <name>Q2HD19_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FK506-binding protein</fullName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_01885</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIase that acts as a histone chaperone. Histone proline isomerase that increases the rate of cis-trans isomerization at prolines on the histone H3 N-terminal tail. Proline isomerization influences H3 methylation thereby regulating gene expression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to histones H3 and H4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221106.1">
        <property type="nucleotide sequence ID" value="XM_001221105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HD19"/>
    <dbReference type="FunCoup" id="Q2HD19">
        <property type="interactions" value="490"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HD19"/>
    <dbReference type="GeneID" id="4387980"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01885"/>
    <dbReference type="eggNOG" id="KOG0552">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022297_3_1_1"/>
    <dbReference type="InParanoid" id="Q2HD19"/>
    <dbReference type="OMA" id="CPPHMAY"/>
    <dbReference type="OrthoDB" id="77911at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023566">
        <property type="entry name" value="PPIase_Fpr3/Fpr4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001473">
        <property type="entry name" value="FK506-bp_FPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="10">
        <location>
            <begin position="385"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="65"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="213"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="216"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ93650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="471" mass="50885" checksum="945565D1BF934ECF" modified="2006-03-21" version="1">MSPLLPVAVYGLEIPTGELLVPAEIEFPATIRITMAAIDPTAAPETDGQGNVPSVPRSTLKIYKANVDEDDDDEDDYLESLIGGGDDDDESDDEDEEANGGPSDPSKSSKARRAAAIKKILEATQEDSDDEMEDAKPNAAKSKGKSKASDEDEEESDEEDDDGPDANMEEYVVCTLDTERTYQQPIDITVGEGEKIFFSVKGTHAVYLTGNYVVPQDEEEDDDEEYSDDEYDLPPGLEDVDSDEMSDELDDIDGTPRIKEIDTDEEEAPKLVQTKKSKKRAAEEEAEGLDEIMAKDDKKLSKKQKKLKNNQGEAVAAEAKAKESAAKGDKKVQFAKNLEQGPTGPAKDKAENKGDKKGATGGVRVVQGVTVDDRKAGTGRTAKSGDKVGMRYIGKLQNGKVFDSNKKGTPFSFKIGKGEVIKGWDIGIAGMAVGGERRLTIPAHLAYGSRAIPGIPANSTLIFDVKLLEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDX0</accession>
    <name>Q2HDX0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_01584</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220805.1">
        <property type="nucleotide sequence ID" value="XM_001220804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDX0"/>
    <dbReference type="GeneID" id="4386296"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01584"/>
    <dbReference type="eggNOG" id="ENOG502QPTQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007127_11_0_1"/>
    <dbReference type="InParanoid" id="Q2HDX0"/>
    <dbReference type="OMA" id="VFKTVCY"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000014">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ93349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="322" mass="37329" checksum="176967FDB99F4314" modified="2006-03-21" version="1">MKVISKAFGIHPLTAEDIMMQEQREKVELFRNYYFVNYRSFDQDLASDNFLEPVNMYVVVFRECVLSFHFSVTPHPANVRRRIRQLRDYLILSSDWISYAIIDDITDVFVPLIQNIEDEVDEIDYAILQMHSEEDQAMREEKRRLNEKSDSAEVKSAEAGRDMLRRVGDCRKKVMSLYRLLSNKADVIKGFAKRCNEHWEVAPRSEIGLYLGDIQDHIVTMTSNLSHYEKILARSHGNYLAQINIRMNERQEQTADVLGKLTVLGTIVLPMNIITGLWGMNVWVPGQEYEGDLNWFIAITAGLLCFGLGCFMIAKRVFKNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEG0</accession>
    <name>Q2HEG0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220615.1">
        <property type="nucleotide sequence ID" value="XM_001220614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEG0"/>
    <dbReference type="STRING" id="306901.Q2HEG0"/>
    <dbReference type="GeneID" id="4387691"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01394"/>
    <dbReference type="eggNOG" id="ENOG502TBKV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1396146_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HEG0"/>
    <dbReference type="OrthoDB" id="3924764at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209417" evidence="2">
        <location>
            <begin position="23"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="195" mass="20821" checksum="478D269F03FF3958" modified="2006-03-21" version="1">MHHAAAMPLFSSLLLLAGLAAAAPVVNLDDKCESQTICVDAINTCGIKYGGCYDVCDLSAKPVAPPCPTTTKKPPVPTTTKVITKVTTLKPKPTTTQKTTKKPTPTTTKKTTKKPTHKPTTKKPTPTPTKKPTPKPTSTKKPHPTTTKKPTVKPPVNPDPDQKLHHLYHQSCQLQQPTSRSAGDGINECGIMYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEG2</accession>
    <name>Q2HEG2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="7">1.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Iron-sulfur subunit of complex II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CHGG_01392</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="7"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220613.1">
        <property type="nucleotide sequence ID" value="XM_001220612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEG2"/>
    <dbReference type="FunCoup" id="Q2HEG2">
        <property type="interactions" value="617"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HEG2"/>
    <dbReference type="GeneID" id="4387064"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01392"/>
    <dbReference type="eggNOG" id="KOG3049">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1128942_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HEG2"/>
    <dbReference type="OrthoDB" id="1696654at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="16" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <keyword evidence="22" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="21">
        <location>
            <begin position="68"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="178"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EAQ93157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="246" mass="26762" checksum="35AAD0C71F438A57" modified="2006-03-21" version="1">MAALRSSASLLLGAASRPVLRAAAAAPAAVRGMAQVVDGQQQSQSASGDAAKLKTFQIYRWNPDTPTEKPKMQSYTLDLNKTGPMVLDALIRIKNELDPTLTFRRSCREGICGSCAMNINGTNTLACLCRIPAEDSAELKIYPLPHTYVVKDLVPDLTQFYKQYKSIKPYLQRDTARSIGKVRRTARSSTASTSASSARAARRRAPRIGGTRRSTWAPPSCSSRTGGSSTRVTRRRPSARTPSTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEQ9</accession>
    <name>Q2HEQ9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidoligase enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220516.1">
        <property type="nucleotide sequence ID" value="XM_001220515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEQ9"/>
    <dbReference type="GeneID" id="4388228"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01295"/>
    <dbReference type="HOGENOM" id="CLU_032734_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HEQ9"/>
    <dbReference type="OrthoDB" id="4570706at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022025">
        <property type="entry name" value="Amidoligase_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12224">
        <property type="entry name" value="Amidoligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="47891" checksum="40C4C308BA549891" modified="2006-03-21" version="1">MPNPPPKPIFGVEIEIFVKVKRDVQRDVERYRGSLPLHWREWDFNLSNRSTDNYKTGKQRICVKTALSALIKESLGTGGVEIISPPMSVARRWQSEIREVFDAIGEQFELWTHPVTSCHVHVSPGPTSSTKYRPDQLVRIAKAAFFWEKALKQILPHDRRENHYAKPNHKAFGTSMYRHVKDDSWKPLFNAIDNEMDRFENHRQGQKKCFCIKIAGGHLSDPNHKYRKERYLSQNFLPYTRIGTVELRRQGGVASAQSAIHRVLLAVTLHVSARRYDFRGAASRKDHPTAKELISELAGCIKNLPRTCHGTRFVNYLNQCVERYGGNELSERAINAYEYRLHDNSGSSTMSAPTRRQTTSTRGGGGGGGGRGGGGGGGGRGGGGGGRGGGGGGGGRGGGGGGRGGGGGGRGGLNRVTTTRTSDGRIVNVVNAAPSGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFJ5</accession>
    <name>Q2HFJ5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220230.1">
        <property type="nucleotide sequence ID" value="XM_001220229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFJ5"/>
    <dbReference type="STRING" id="306901.Q2HFJ5"/>
    <dbReference type="GeneID" id="4387460"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01009"/>
    <dbReference type="eggNOG" id="ENOG502RJQC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072358_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HFJ5"/>
    <dbReference type="OMA" id="GNIHTRV"/>
    <dbReference type="OrthoDB" id="5030973at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="307" mass="34697" checksum="807B161CEE552351" modified="2006-03-21" version="1">MAEVDETSVIPEADEPLSSFGLSLSPGEIDSEFRTQNASPEDFERRNVIERTQTAIDIRCDLMEVSHGWLQESRDDEYATLMVLRFRFDPQKTSRRLRRVRINIEFLSSSADRDAPEVFAIAPEERWSVAPTVDQEEVVRGAELHVAASGIPFVDGGVNAKLEKTVTRDLSDATTVTGSINLGEGRNSGLSTCAVWTLLENRRRETGVPDTLRVAILLKREDEEPYKAMVTLEAEADLATKLGSFFRFSAKQPLDDPILFNPRWEPKKPRKGRSRDVENIGDMDLYSRCEVRVAPEVFFLRGRHELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFQ0</accession>
    <name>Q2HFQ0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220175.1">
        <property type="nucleotide sequence ID" value="XM_001220174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFQ0"/>
    <dbReference type="GeneID" id="4387204"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00954"/>
    <dbReference type="eggNOG" id="ENOG502S9U1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123479_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HFQ0"/>
    <dbReference type="OMA" id="DFHTSNV"/>
    <dbReference type="OrthoDB" id="2097653at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209145" evidence="1">
        <location>
            <begin position="18"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="163" mass="17737" checksum="07664930A6F4446C" modified="2006-03-21" version="1">MSRLILLLFTLFALSLAAPPQPWYEKYQQRRVMVPQSYYEGLSLRRQKPISPNSVRDVVCLDTSTRFVLYDEYAASLAICGSIAGPLATRCGGAPAETVGRSGKAVFTLEATERKQGATINVSKDRWARCVAAAREACPQGSFEGVCVGAATRGDVRFRLGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG48</accession>
    <name>Q2HG48_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Pre-mRNA-processing protein prp40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_00806</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220027.1">
        <property type="nucleotide sequence ID" value="XM_001220026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG48"/>
    <dbReference type="FunCoup" id="Q2HG48">
        <property type="interactions" value="1045"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HG48"/>
    <dbReference type="GeneID" id="4386259"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00806"/>
    <dbReference type="eggNOG" id="KOG0152">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005825_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HG48"/>
    <dbReference type="OMA" id="RDEIFQD"/>
    <dbReference type="OrthoDB" id="187617at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000033">
        <property type="entry name" value="Formin binding protein (FNB3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000013">
        <property type="entry name" value="pre-mRNA-processing protein 40A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039726">
        <property type="entry name" value="Prp40-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864">
        <property type="entry name" value="PRE-MRNA-PROCESSING PROTEIN PRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864:SF0">
        <property type="entry name" value="PRP40 PRE-MRNA PROCESSING FACTOR 40 HOMOLOG A (YEAST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25432">
        <property type="entry name" value="FF_PRPF40A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="8">
        <location>
            <begin position="152"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="8">
        <location>
            <begin position="221"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="8">
        <location>
            <begin position="368"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="560"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="560"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="607"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="643"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="798"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ92571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="840" mass="99145" checksum="302952385D619A74" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGG1</accession>
    <name>Q2HGG1_CHAGB</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2637846_0_0_1"/>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="77" mass="8678" checksum="49BAD5F89A355BE6" modified="2006-03-21" version="1">MALPGCHLAVTTRFLFSLWRCDCWRQQHRRPLWACCGTVLATNSCTVTAAPCRPSRQDTADEPNAETASRRIETFPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGQ1</accession>
    <name>Q2HGQ1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Haloacid dehalogenase, type II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219824.1">
        <property type="nucleotide sequence ID" value="XM_001219823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGQ1"/>
    <dbReference type="STRING" id="306901.Q2HGQ1"/>
    <dbReference type="GeneID" id="4387153"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00603"/>
    <dbReference type="eggNOG" id="ENOG502S19E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_3_0_1"/>
    <dbReference type="InParanoid" id="Q2HGQ1"/>
    <dbReference type="OMA" id="WHRLNPW"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019120">
        <property type="term" value="F:hydrolase activity, acting on acid halide bonds, in C-halide compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006328">
        <property type="entry name" value="2-HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01428">
        <property type="entry name" value="HAD_type_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF3">
        <property type="entry name" value="HALOACID DEHALOGENASE, TYPE II (AFU_ORTHOLOGUE AFUA_2G07750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ92368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="30278" checksum="5064AD8C81A6CCFD" modified="2006-03-21" version="1">MSSTHPLASTIKALTFDLFGTAVDWRSSITSALTAAATDKLTSPAFPTLPEAARSRLESLTRDDWSVFAQSWRNAYSGFTRSFVPGTTPWKDVDTLHRESLASLLEEWGLAGVYDEQELDALNRSWHFLTPWADVVAGMRRLNGVFATASLSNGNTALLEDMNAHAQLGLGRLISAEDFKQYKPSGEVYLGACRMLELEPSQVAMVAAHLKDLAAASEYGMRTVYVERPGEEEWKPDEERSIRFGAGGPFNPRTEKRARGARGSGSVDGLVDNMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH68</accession>
    <name>Q2HH68_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">THUMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219657.1">
        <property type="nucleotide sequence ID" value="XM_001219656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH68"/>
    <dbReference type="FunCoup" id="Q2HH68">
        <property type="interactions" value="768"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HH68"/>
    <dbReference type="GeneID" id="4387684"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00436"/>
    <dbReference type="eggNOG" id="KOG3943">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039352_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HH68"/>
    <dbReference type="OMA" id="VEHAWEP"/>
    <dbReference type="OrthoDB" id="367221at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2300.10">
        <property type="entry name" value="THUMP superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THUMP" evidence="2">
        <location>
            <begin position="255"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ92201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="362" mass="39406" checksum="1E113B38561EAA75" modified="2006-03-21" version="1">MTENGKRKDAPGGGGDSRSKKKKTGNAGKWKTSHQQAKVLAQDSHLQPGDTGVWVTCARHQEAKAAREIGVLFSEYAEKLYDIKSIHDAQPSGGDDDGAEDDIEAAIAREVAALTAKPTPTSGGTSPEEPNRMTPLKMNVDCLLYVKTQPPVDPVAFVRRICEDARRCGELPGLMRCRYVNRLTPISVMGKASENGLVEVAKEALKGWFDLGGKRGTEGEIKSTVEGELAGDGDGKKDTTEAHSRAPVSEEAGSEKKPFTFAIRPTIRNHSNLKRDVVINTVARLINDDLHKVNLTSPDKVILIDIYQVNLTSRRGPWLTPDPGGHRPEAFQRHGSGLGECSWAETPHPSLVEHAWEPRGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHK1</accession>
    <name>Q2HHK1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the caleosin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219524.1">
        <property type="nucleotide sequence ID" value="XM_001219523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHK1"/>
    <dbReference type="STRING" id="306901.Q2HHK1"/>
    <dbReference type="GeneID" id="4386656"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00303"/>
    <dbReference type="eggNOG" id="ENOG502QQD0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062049_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHK1"/>
    <dbReference type="OMA" id="FEFCEKS"/>
    <dbReference type="OrthoDB" id="640742at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007736">
        <property type="entry name" value="Caleosin-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31495:SF0">
        <property type="entry name" value="BINDING PROTEIN CALEOSIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G13750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31495">
        <property type="entry name" value="PEROXYGENASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05042">
        <property type="entry name" value="Caleosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ92068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="31914" checksum="7F28CA8DE8FFA89E" modified="2006-03-21" version="1">MPDPHSNPNPNLALPFAHTAPNCPATAERQQAALADAFIAKPAIARANLAVSADVPEGSAVSGRGALGHFTVLQQHVLFWDRDGDGQIYPWDTYVGFRDLGFSVLFSLLAVVIINLNFSYPTRLAVSWWPDPWFRVYVGSIHKAKHGSDSGTYDKEGRFVPQMFEDVFAKWDVHGSGSLSAGELWHMIKGNRLAADPFGVCPPTDACCADDGTKRAQWGAAIFEFGTTWLLVQKDGRVSKEDLRQTYDGTIFWRIKEAREKGKRWNKGFGFRDLVQLGQREFKARVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI45</accession>
    <name>Q2HI45_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OsmC family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_00109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219330.1">
        <property type="nucleotide sequence ID" value="XM_001219329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HI45"/>
    <dbReference type="STRING" id="306901.Q2HI45"/>
    <dbReference type="GeneID" id="4388053"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00109"/>
    <dbReference type="eggNOG" id="ENOG502SD2C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100275_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HI45"/>
    <dbReference type="OMA" id="KSKWINE"/>
    <dbReference type="OrthoDB" id="3906254at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052924">
        <property type="entry name" value="OsmC/Ohr_hydroprdx_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35368">
        <property type="entry name" value="HYDROPEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35368:SF1">
        <property type="entry name" value="HYDROPEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="OsmC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ91874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22171" checksum="FEEF19ABF07E3BF7" modified="2006-03-21" version="1">MSRTLRLTTLPTRHLTTTNLTTRPSLLITTTTTTTITQYPRPFSTTRPRPNDTLPVRVSGTGTGTVQHISVPGKTYTFTADTYPLLGGGDSAPSPVVYSLASLSSCNQVTGHVVARDHGISLGKWEVQVEADLPTAVLVRGAAEGNPNWEGVRLRVRVQTDAEGERWERFVSEVERRCPITRLFRLSGVRWESKWVNERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI82</accession>
    <name>Q2HI82_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_00072</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219293.1">
        <property type="nucleotide sequence ID" value="XM_001219292.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HI82"/>
    <dbReference type="GeneID" id="4387253"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00072"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_23_2_1"/>
    <dbReference type="InParanoid" id="Q2HI82"/>
    <dbReference type="OrthoDB" id="10030083at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="6">
        <location>
            <begin position="1322"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="468"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="608"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="576"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="629"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ91837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="2049" mass="228184" checksum="A182DA638420A39A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM20</accession>
    <name>Q2GM20_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226251.1">
        <property type="nucleotide sequence ID" value="XM_001226250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GM20"/>
    <dbReference type="GeneID" id="4397288"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10984"/>
    <dbReference type="HOGENOM" id="CLU_1354455_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GM20"/>
    <dbReference type="OrthoDB" id="10360290at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="202" mass="22718" checksum="E352CD12AA4DCD16" modified="2006-03-21" version="1">MDRTNTQEENASQALEVNHRPSPTANQTTYKPNPQTPNTTPKCSPVPRAIHRQLPRIQTTPPTATQQVDWLAIQLHNFSSPSPTAQESHPPPTTTHQPFQPFQLTNLAGPQPTTVRDAVQLKLAKLGPSRRGLECTAELDVLMDRLRYVVRPESAEEARVVGRRRDPAEVSAFWGKVREGVRVADEEVWRSRWDGLRWGVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMH9</accession>
    <name>Q2GMH9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226092.1">
        <property type="nucleotide sequence ID" value="XM_001226091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMH9"/>
    <dbReference type="STRING" id="306901.Q2GMH9"/>
    <dbReference type="GeneID" id="4397196"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10825"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_8_1_1"/>
    <dbReference type="InParanoid" id="Q2GMH9"/>
    <dbReference type="OMA" id="ANSHMAN"/>
    <dbReference type="OrthoDB" id="5231586at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22695" checksum="3786F635E233F74E" modified="2006-03-21" version="1">MHCSPRRISSSLFHQILPQPALRSPPKEARLRMAVEAIGKNKSLNIRAAARLYNVPEATIRHRRTGPSPRRDLPANSHMANHLLRERDAPPVGKLWAHNFVKRQPQLRTRRTRRYDYQRAKCEDPKVIGEWFTLVQNTRAKYGIVDDDVYNFDETGFMMGIIFAGMVVTTSDGRSKAKLAQPGNREWATVTQDRHTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMP7</accession>
    <name>Q2GMP7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_10757</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ82939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226024.1">
        <property type="nucleotide sequence ID" value="XM_001226023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMP7"/>
    <dbReference type="GeneID" id="4397297"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10757"/>
    <dbReference type="eggNOG" id="KOG4231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_388294_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GMP7"/>
    <dbReference type="OMA" id="SWEREAP"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07216">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PNPLA" evidence="6">
        <location>
            <begin position="26"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="5">
        <location>
            <begin position="30"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="5">
        <location>
            <begin position="66"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="5">
        <location>
            <begin position="218"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ82939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="711" mass="77919" checksum="38136C68E70E60D0" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN19</accession>
    <name>Q2GN19_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoplasmic reticulum lectin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Protein OS-9 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_10635</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
            <orientation evidence="1 7">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the OS-9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228562.1">
        <property type="nucleotide sequence ID" value="XM_001228561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN19"/>
    <dbReference type="STRING" id="306901.Q2GN19"/>
    <dbReference type="GeneID" id="4396511"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10635"/>
    <dbReference type="eggNOG" id="KOG3394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025069_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GN19"/>
    <dbReference type="OMA" id="AYPQFEV"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0430">Lectin</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208282" description="Endoplasmic reticulum lectin" evidence="9">
        <location>
            <begin position="18"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="165"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="62"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="472"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="499"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ84231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="572" mass="63005" checksum="F4BC8F97FC9F8F22" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN40</accession>
    <name>Q2GN40_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="3">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">CHGG_10614</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="3"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228541.1">
        <property type="nucleotide sequence ID" value="XM_001228540.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4396809"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10614"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000879_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GN40"/>
    <dbReference type="OrthoDB" id="5106181at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="14" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="20" id="KW-0862">Zinc</keyword>
    <keyword evidence="20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="23">
        <location>
            <begin position="622"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A2" evidence="24">
        <location>
            <begin position="769"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="25">
        <location>
            <begin position="1807"/>
            <end position="1964"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="22">
        <location>
            <begin position="2114"/>
            <end position="2173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="161"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="475"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="2079"/>
            <end position="2113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="2164"/>
            <end position="2241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="482"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="2189"/>
            <end position="2200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="2224"/>
            <end position="2241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EAQ84210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="2241" mass="253170" checksum="84517663A6E14353" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN58</accession>
    <name>Q2GN58_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228523.1">
        <property type="nucleotide sequence ID" value="XM_001228522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN58"/>
    <dbReference type="GeneID" id="4397084"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10596"/>
    <dbReference type="HOGENOM" id="CLU_2849506_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GN58"/>
    <dbReference type="OrthoDB" id="4555951at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="65" mass="7320" checksum="33C67A3D26530851" modified="2006-03-21" version="1">MPNRGKCTNSITNPNWTQWKKANPGNKLNPNIEKIACPCRAFVAKDASKPDKKCTCNHDNKLHMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNE6</accession>
    <name>Q2GNE6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MutL C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228435.1">
        <property type="nucleotide sequence ID" value="XM_001228434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNE6"/>
    <dbReference type="STRING" id="306901.Q2GNE6"/>
    <dbReference type="GeneID" id="4396213"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10508"/>
    <dbReference type="eggNOG" id="KOG1977">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1049737_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNE6"/>
    <dbReference type="OMA" id="TRCANAD"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF47">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="1">
        <location>
            <begin position="60"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="265" mass="29488" checksum="E26018A082689EBA" modified="2006-03-21" version="1">MEPQIPQVFQGFNTFHCGHGRDNFEPRGLESLAAAENSNGNVLATLEGRISKASLQVAEVVAQVDSKFILTKVGADIQPGPPGGASESDPLLILIDQHAADERCKVENLLKAYFVSSPASTGQLVAQTQNLDKPLRFDLSKQDGDLLVRFKKHFAHWGVVYETLHERSPHVTVEVQSLPPSIVERCRLEPRLLIDLLRKEVWKLHETGSSGARKQADKNRDDDDWVARFHDCPNGIMELINSRACRSAIMFNDPLTTEQSSKLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNI8</accession>
    <name>Q2GNI8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Deoxyhypusine synthase</fullName>
            <ecNumber evidence="6">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_10466</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="6"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228393.1">
        <property type="nucleotide sequence ID" value="XM_001228392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNI8"/>
    <dbReference type="FunCoup" id="Q2GNI8">
        <property type="interactions" value="621"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GNI8"/>
    <dbReference type="GeneID" id="4396669"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10466"/>
    <dbReference type="eggNOG" id="KOG2924">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039781_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNI8"/>
    <dbReference type="OMA" id="HSIINAN"/>
    <dbReference type="OrthoDB" id="294378at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000003">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ84062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="362" mass="40027" checksum="28CD1E91AB8325A2" modified="2006-03-21" version="1">MDSHAPPSAATDAVLVKSVEMPENAQKVEELDFNKFKGRPITVDDLFQGMKHMGFQASSMCEAYGGRVPRRGALPTNRVQRAWKDPESGDKTTIFLGYTSNMISSGLRGVFRYLVQHKHVSAIVTTAGGIEEDFIKCLGDTYMSSFSEAGAELRSKGLNRIGNLVVPNSNYCAFEDWVVPILDKMLEEQEASRGTEDELHWTPSKIIHRLGKEINDERSVYYWAYKNNIPVFCPALTDGSLGDMLYFHTFKTSPQQLRVDIVEDIRKINTIAVRAKRAGMIILGGGVVKHHIANACLMRNGAESAVYINTAQEFDGSDAGARPDEAVSWGKIKVGADAVKVYVEATTCFPFIVANTFAKDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNY6</accession>
    <name>Q2GNY6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228245.1">
        <property type="nucleotide sequence ID" value="XM_001228244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNY6"/>
    <dbReference type="GeneID" id="4396594"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10318"/>
    <dbReference type="HOGENOM" id="CLU_000680_25_3_1"/>
    <dbReference type="InParanoid" id="Q2GNY6"/>
    <dbReference type="OrthoDB" id="4842715at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="345" mass="37286" checksum="6C5399CCA5BE5C83" modified="2006-03-21" version="1">MTRKAAVKLANPGGGTSPVKPEGSARFLGVWLDWKLNWKAHLVAVEKKLRTQSYALSRIVAKTWGMGLAKAREVYTKCIRSALAYGASSFHIPTDVGGEPVKKGITEALGKAQNKSLRIVIPKTDSNEPIWTTVKAARRRRGALSSPPTARYSRLSSRRGNRGRPRTLGPQGPTAVERAAGTVMRWTGGIVGGAIPERNPKEARRSQQGEELTADPNPDGSNRLTGLLVYTGSPGGSDSCLRVWRGTRDCRTPGSVVFGPTVDSKMGENWNSDTTGLLLCSTRHQSHDCTAREESSRLADGLGEAADVQLSQEARAGRGGLKRPRSEARRPPLFVYADSPERIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPL0</accession>
    <name>Q2GPL0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitric oxide dioxygenase</fullName>
            <ecNumber evidence="4">1.14.12.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_10094</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 nitric oxide + NADH + 2 O2 = 2 nitrate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 nitric oxide + NADPH + 2 O2 = 2 nitrate + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="4"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228021.1">
        <property type="nucleotide sequence ID" value="XM_001228020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPL0"/>
    <dbReference type="FunCoup" id="Q2GPL0">
        <property type="interactions" value="305"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GPL0"/>
    <dbReference type="GeneID" id="4396645"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10094"/>
    <dbReference type="eggNOG" id="KOG3378">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_12_0_1"/>
    <dbReference type="InParanoid" id="Q2GPL0"/>
    <dbReference type="OMA" id="ADIHYEV"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase NAD(P)H activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071500">
        <property type="term" value="P:cellular response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046210">
        <property type="term" value="P:nitric oxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08922">
        <property type="entry name" value="FHb-globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06184">
        <property type="entry name" value="flavohem_like_fad_nad_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.10:FF:000003">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000034">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0216">Detoxification</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin" evidence="16">
        <location>
            <begin position="3"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="17">
        <location>
            <begin position="152"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ83690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="424" mass="46230" checksum="EF31E8E03AE46DAD" modified="2006-03-21" version="1">MAAVTESQIAIVKATAPVLQEHGVTITTVFYENLLRENPDLHNVFSSTSQVTGRQPRALASAVLGYATYIDDLPKLKHAVERIAHKHVSLQVTPAQYDVVGKYLIQAIGQVLGDAATPEIVDAWVAAYGVLAGVFINREGEMYKANAAENWVGWRKFRITRKVPESNSITSFYLTPVDAAIPLPTFFPGQYVSLQVFVPELGYLQSRQYSLSEGPNPKGEYYRISVKKEEAIAETGVPGIISNMLHAKYAVGDEVELSHPQGEFYVDPSDTTKEGVPAVLISAGVGATPLKSILDSLTTSAGRPRPAVKRPVSWIHSARSSAAQPFGDAVRQICRENESVSANVFLRNLDPADKAGVHYEFGDMRLDLAKLDHDRDLFVGNPAAEYFICGPEPFMIDVRSALAALGVDRSRIFLELFATGDVPA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2026-01-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPT5</accession>
    <name>CCDD_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MFS-type transporter ccdD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cochliodone A biosynthesis cluster protein D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ccdD</name>
        <name type="ORF">CHGG_10019</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2025" name="J. Am. Chem. Soc." volume="147" first="11555" last="11563">
            <title>Mechanism of Unexpected In-Trans Post-PKS Polyketide Reduction in Cochliodone Biosynthesis.</title>
            <authorList>
                <person name="Sarmales-Murga C."/>
                <person name="Sato M."/>
                <person name="Kosaka M."/>
                <person name="Akaoka F."/>
                <person name="Watanabe K."/>
            </authorList>
            <dbReference type="PubMed" id="40111931"/>
            <dbReference type="DOI" id="10.1021/jacs.5c03717"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="3">MFS-type transporter; part of the gene cluster that mediates the biosynthesis of cochliodone A, a dimerized azaphilone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Does not affect the production of cochliodone A.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227946.1">
        <property type="nucleotide sequence ID" value="XM_001227945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPT5"/>
    <dbReference type="GeneID" id="4395964"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10019"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="InParanoid" id="Q2GPT5"/>
    <dbReference type="OMA" id="AGYQFIA"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF193">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G00940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000462665" description="MFS-type transporter ccdD">
        <location>
            <begin position="1"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="40111931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="40111931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ83615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="561" mass="59714" checksum="30E5B49B8F8F5D64" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPU5</accession>
    <name>Q2GPU5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227936.1">
        <property type="nucleotide sequence ID" value="XM_001227935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPU5"/>
    <dbReference type="STRING" id="306901.Q2GPU5"/>
    <dbReference type="GeneID" id="4396236"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10009"/>
    <dbReference type="eggNOG" id="KOG0700">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_787987_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPU5"/>
    <dbReference type="OMA" id="THIPGIN"/>
    <dbReference type="OrthoDB" id="420076at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="123"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="344" mass="37365" checksum="DED0CBE11315C81E" modified="2006-03-21" version="1">MWLLRPCKTAQRRLNIHKVTLIRLLQIPAKTYRLYSTNGSSSNSSRENGKAAGYTALAAAAGGGGIWWLTSSLKQKHQTKGMPCFTDAPTDQLAPALGPSKEGVSHILSNGAYSIPVTHIPGINRYDGSQLASSSPCEDRFVHGELPSPRNDGGHWAAWAIFDGHVGWQTADLLEKQLLPFMRHSLAQAKPDLGEGSAATDGAVQDAIIRAFVRLDDALMKKVSEAIESKTPLPDKLAGLMPGYAGSCALLSMYDPLTSTLHVACTGNSRAVLGRKRPDGSWEAVPLSLDQTAHNPEEFARLQREHPGEKDVVSMKDGRILGIGLSRTFRDSRWKLSDELHQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQL1</accession>
    <name>Q2GQL1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAM1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Outer kinetochore protein DAM1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_09743</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227670.1">
        <property type="nucleotide sequence ID" value="XM_001227669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQL1"/>
    <dbReference type="STRING" id="306901.Q2GQL1"/>
    <dbReference type="GeneID" id="4396892"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09743"/>
    <dbReference type="eggNOG" id="ENOG502S08R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083960_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GQL1"/>
    <dbReference type="OMA" id="DDETTFM"/>
    <dbReference type="OrthoDB" id="5586015at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990537">
        <property type="term" value="C:mitotic spindle polar microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013962">
        <property type="entry name" value="DASH_Dam1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08653">
        <property type="entry name" value="DASH_Dam1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="34"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAQ83339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="189" mass="21202" checksum="4C39F3BF5AF375FE" modified="2006-03-21" version="1">MADPTITVAARLGGMLALGSPKHQVDNHHSALLPRPHRYGCQPLRMSHDDTSHRRARSTSRSRPTTPLRPSSRSSFRDSARNSVQGDAASFPLNTFEPAFAELSDAVADLEANMMHFQLMHESLSRFSESFASFLYGLNMNAFCVDFPEGPMTESFKRMKLKEEQEQQHNATRIPERSASDIDTEATFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GR10</accession>
    <name>Q2GR10_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227521.1">
        <property type="nucleotide sequence ID" value="XM_001227520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GR10"/>
    <dbReference type="GeneID" id="4396129"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09594"/>
    <dbReference type="eggNOG" id="ENOG502RJCR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_565225_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GR10"/>
    <dbReference type="OMA" id="QNDRGIA"/>
    <dbReference type="OrthoDB" id="4585160at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="485" mass="53127" checksum="978382BA147DD264" modified="2006-03-21" version="1">MNRKERRLPRLTAEELANPCTRISLDGVEVQLWQVAHVYGISHDMPSPDLRGGASSQDFRALYSTTTQNDRGIASSSTSTDTRASDVTEQRLLPSLPVLPLNIPTRREAQRSKRRGDGRRGDGRRDHARPDPDTNELLRLIDDFADTSWPTEVQLEEPRIETTEPAATSIGNAPKLKGVIWVDCSFPPPPYPPPNRSLPPLPPQPARNRHSGPQQRLRLTTGPVVAPDTVPATAPRLLPRAVDKSLEYPESDRDDDAGSERTITPRASQKQLVPTARPQPRPQPRPRDVSMPIGQVASKSPVVARPVTTARAASASILRNRGEEIYRPRRQEFGSTETRPKAASPTLPYPLPDLLLNPPSFLQHPPDLSQQPYLNQQPGATARESPQPNKAKSSSNVATPVTSPVAPTSDDDAAVTSRWSSDSEQEAESKLKKLKRALSFSRLRPRKPSLFQKQTGSEANKSMASIGGKHTPGPSGSRRGSKTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRA9</accession>
    <name>Q2GRA9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_09495</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227422.1">
        <property type="nucleotide sequence ID" value="XM_001227421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRA9"/>
    <dbReference type="FunCoup" id="Q2GRA9">
        <property type="interactions" value="1091"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GRA9"/>
    <dbReference type="GeneID" id="4395746"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09495"/>
    <dbReference type="eggNOG" id="KOG0556">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GRA9"/>
    <dbReference type="OMA" id="EYIVTHA"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000038">
        <property type="entry name" value="Aspartate--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF2">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="257"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="21"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="39"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ85481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="916" mass="104211" checksum="307B1EA4DEA984EE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRJ9</accession>
    <name>Q2GRJ9_CHAGB</name>
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        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    <organism evidence="2 3">
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227332.1">
        <property type="nucleotide sequence ID" value="XM_001227331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRJ9"/>
    <dbReference type="STRING" id="306901.Q2GRJ9"/>
    <dbReference type="GeneID" id="4394902"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09405"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_23_5_1"/>
    <dbReference type="InParanoid" id="Q2GRJ9"/>
    <dbReference type="OMA" id="HYESASM"/>
    <dbReference type="OrthoDB" id="5243754at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="588" mass="64479" checksum="DF4BAD4938578F86" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GS14</accession>
    <name>Q2GS14_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_09240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227167.1">
        <property type="nucleotide sequence ID" value="XM_001227166.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4395775"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09240"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_237419_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GS14"/>
    <dbReference type="OrthoDB" id="3059164at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="5">
        <location>
            <begin position="725"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="154"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="455"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="567"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="122"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="578"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ85226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1828" mass="204934" checksum="FDF1724C1FACEC74" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GS61</accession>
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            <fullName evidence="5">Ataxin-10 homolog</fullName>
        </recommendedName>
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        <name evidence="8" type="ORF">CHGG_09193</name>
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    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a role in the regulation of cytokinesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ataxin-10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227120.1">
        <property type="nucleotide sequence ID" value="XM_001227119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GS61"/>
    <dbReference type="STRING" id="306901.Q2GS61"/>
    <dbReference type="GeneID" id="4394846"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09193"/>
    <dbReference type="eggNOG" id="ENOG502SC2U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005559_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GS61"/>
    <dbReference type="OMA" id="FIMHNEH"/>
    <dbReference type="OrthoDB" id="379794at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051374">
        <property type="entry name" value="Ataxin-10/CTR86_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255:SF0">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ataxin-10" evidence="7">
        <location>
            <begin position="761"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="392"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="684"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="820"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="872"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="690"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="826"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="903"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="920"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="935"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="947"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="988"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ85179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1013" mass="112571" checksum="BEB43ECAFCEF140F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-04-05" modified="2025-06-18" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSA4</accession>
    <name>ACUK_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Transcription activator of gluconeogenesis CHGG_09150</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">CHGG_09150</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ERT1/acuK family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227077.1">
        <property type="nucleotide sequence ID" value="XM_001227076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSA4"/>
    <dbReference type="SMR" id="Q2GSA4"/>
    <dbReference type="FunCoup" id="Q2GSA4">
        <property type="interactions" value="173"/>
    </dbReference>
    <dbReference type="GeneID" id="4395861"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09150"/>
    <dbReference type="eggNOG" id="ENOG502R1M5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010748_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GSA4"/>
    <dbReference type="OMA" id="VMTTCKL"/>
    <dbReference type="OrthoDB" id="2538135at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF1">
        <property type="entry name" value="TRANSCRIPTION ACTIVATOR OF GLUCONEOGENESIS ERT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0312">Gluconeogenesis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000406437" description="Transcription activator of gluconeogenesis CHGG_09150">
        <location>
            <begin position="1"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="PAS">
        <location>
            <begin position="455"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="319"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="587"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="660" mass="72331" checksum="445EBF7A4870F0FA" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSA6</accession>
    <name>Q2GSA6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein TSR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_09148</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TSR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227075.1">
        <property type="nucleotide sequence ID" value="XM_001227074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSA6"/>
    <dbReference type="FunCoup" id="Q2GSA6">
        <property type="interactions" value="138"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GSA6"/>
    <dbReference type="GeneID" id="4395859"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09148"/>
    <dbReference type="eggNOG" id="KOG4032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074896_0_2_1"/>
    <dbReference type="InParanoid" id="Q2GSA6"/>
    <dbReference type="OMA" id="QSNWGGP"/>
    <dbReference type="OrthoDB" id="263560at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10273">
        <property type="entry name" value="WGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ85134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24949" checksum="5FB62022E0C285E6" modified="2006-03-21" version="1">MASTSNPSPATCQANFEQSVAISLHLWEALGLAVQNNWGGPDSADKRDWFAGAVVELFPDVSRLTPAQLQKKNTTAQQQQQPPTQPTQSAPNGSGSAEEPDQADVESLLLQVMLDEFEVNVDDDSAFEVAEQVVRLRGDCLRGKFDEVEALRRRWEGKKGNKVVFKKAEDQDDDTDWDTDDDEEDEDDDGGDVEMNDAPAPPRRERQEPEVDEDGFTKVTKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSB1</accession>
    <name>Q2GSB1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_09143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227070.1">
        <property type="nucleotide sequence ID" value="XM_001227069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSB1"/>
    <dbReference type="ESTHER" id="chagb-q2gsb1">
        <property type="family name" value="Hormone-sensitive_lipase_like"/>
    </dbReference>
    <dbReference type="GeneID" id="4395765"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09143"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004893_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSB1"/>
    <dbReference type="OMA" id="PHWVRTE"/>
    <dbReference type="OrthoDB" id="2336090at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF19">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="145"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="339"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="476"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="688"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="831"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="721"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ85129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="896" mass="97545" checksum="906F0432032E95CD" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSC9</accession>
    <name>Q2GSC9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="14">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_09125</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="14"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227052.1">
        <property type="nucleotide sequence ID" value="XM_001227051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSC9"/>
    <dbReference type="STRING" id="306901.Q2GSC9"/>
    <dbReference type="GeneID" id="4395082"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09125"/>
    <dbReference type="eggNOG" id="KOG2204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_0_2_1"/>
    <dbReference type="InParanoid" id="Q2GSC9"/>
    <dbReference type="OMA" id="PESFGWD"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000047">
        <property type="entry name" value="Mannosyl-oligosaccharide alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF101">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208967" description="alpha-1,2-Mannosidase" evidence="15">
        <location>
            <begin position="22"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="538"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="359"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAQ85111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="554" mass="62005" checksum="D3B38C384F48B87D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSM8</accession>
    <name>Q2GSM8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_09026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226953.1">
        <property type="nucleotide sequence ID" value="XM_001226952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSM8"/>
    <dbReference type="STRING" id="306901.Q2GSM8"/>
    <dbReference type="GeneID" id="4394948"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09026"/>
    <dbReference type="eggNOG" id="ENOG502SG3E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1366099_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSM8"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF47">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ85012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="200" mass="21495" checksum="574D34F9AC122E75" modified="2006-03-21" version="1">MSTNEERFRLTSEKMRPLLALAREALGDGSPLMAGEGAHYPAQLAKKHENIVGVKLTCESVAKITRLAAEFPPERFAVFGEQSDFLIGGLAVGSAGCIAAFANVFPKTVVEVYNLYKAGKTQEALELHRKAALAEQALKSGGIAATKYAASVFTAPLAGVEDAENRMVPRRPYLPPGEEAKRKIKEALAEVAEIEKGIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSP4</accession>
    <name>Q2GSP4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycoside hydrolase family 3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_09010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226937.1">
        <property type="nucleotide sequence ID" value="XM_001226936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSP4"/>
    <dbReference type="STRING" id="306901.Q2GSP4"/>
    <dbReference type="GeneID" id="4394996"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09010"/>
    <dbReference type="eggNOG" id="ENOG502QTNX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="WQMAAEM"/>
    <dbReference type="OrthoDB" id="4215304at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000008">
        <property type="entry name" value="Beta-N-acetylglucosaminidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050226">
        <property type="entry name" value="NagZ_Beta-hexosaminidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480">
        <property type="entry name" value="BETA-HEXOSAMINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480:SF8">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="5">
        <location>
            <begin position="16"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ84996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="405" mass="44048" checksum="C130D069E4AF178D" modified="2006-03-21" version="1">MTNLDADLDPLWQDLDWAIGQMLIMGWDGTEVTPQIRNLIEQHHVGSILLTAKNLKSKLVQELQTIAHQAGHPHPLLIALDQENGGVNSLFDEDYICQFPSSMGQAAASSAELSYKIAKATATEISAVGVNLILGPVLDVLTNARYQPLGVRAIGDDPQEVSQYGIASMNGYKDAGLATCGKHFPSYGNLDFLGSSLDIPIITQTLEELSLSALVPFRNAIATGNLDAMFIGGCGITNPSMSVNHACLSEQVIDDLLRNELGFQGVAISECLEMEGLRNEIGVRTGTVMAVEAGCDLVLLCRAYDVQLEAIAGLKLGVENELITKERIYTSLKRIFRMKKSCTSWQKALNPPGISLLSKIHPGHLALSLKAYDDSIAVIRDNEKLLPLPPTRCTRRKNCSCLHLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSQ2</accession>
    <name>Q2GSQ2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_09002</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226929.1">
        <property type="nucleotide sequence ID" value="XM_001226928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSQ2"/>
    <dbReference type="STRING" id="306901.Q2GSQ2"/>
    <dbReference type="GeneID" id="4395203"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09002"/>
    <dbReference type="eggNOG" id="KOG1650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_10_0_1"/>
    <dbReference type="InParanoid" id="Q2GSQ2"/>
    <dbReference type="OMA" id="QVKVERW"/>
    <dbReference type="OrthoDB" id="2687058at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050794">
        <property type="entry name" value="CPA2_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468">
        <property type="entry name" value="CATION/H + ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468:SF0">
        <property type="entry name" value="K(+)_H(+) ANTIPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="9">
        <location>
            <begin position="6"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="665"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="774"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="774"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="785"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ84988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="838" mass="89298" checksum="1B4BAC94435BE117" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GT13</accession>
    <name>Q2GT13_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226818.1">
        <property type="nucleotide sequence ID" value="XM_001226817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GT13"/>
    <dbReference type="STRING" id="306901.Q2GT13"/>
    <dbReference type="GeneID" id="4395599"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08891"/>
    <dbReference type="eggNOG" id="ENOG502S9JB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1184899_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GT13"/>
    <dbReference type="OMA" id="EIGDQNW"/>
    <dbReference type="OrthoDB" id="2101715at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="234" mass="25204" checksum="C35E36ADC3904C7B" modified="2006-03-21" version="1">MAHFPSEAHSIAAVQLKHPCSPEPISHINITQVPSVPPSLHASRPHSRLDNPRMHIPTYNLILPTFTPPTNPHPQVPLLQTSSPAQVVAHLLRTHLGPNLHSHIFIDFCAGGGGPTPSIERHLNTTTTKQQTNGNRASQEPLHFVLTDLHPHADLWAQAAAQAAAPGAISYVAEPVDAADVPRELIRRYTGAGGGAGGEKKVFRLFNLAFHHFDDELARRILSDTVEGGGEGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GT94</accession>
    <name>Q2GT94_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidoreductase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226737.1">
        <property type="nucleotide sequence ID" value="XM_001226736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GT94"/>
    <dbReference type="STRING" id="306901.Q2GT94"/>
    <dbReference type="GeneID" id="4395174"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08810"/>
    <dbReference type="eggNOG" id="KOG4690">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062297_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GT94"/>
    <dbReference type="OMA" id="DEMEAWA"/>
    <dbReference type="OrthoDB" id="10064411at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039251">
        <property type="entry name" value="OXLD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193:SF3">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase-like" evidence="2">
        <location>
            <begin position="245"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="398" mass="42586" checksum="8AE92CEE1290728E" modified="2006-03-21" version="1">MVGRVHVTDHLTLQTCGEPSSAPGPSSAVYRAFGGQQSRRTFATPPIKSDSPPSPVDPSKEQAHPVGPFYEAILRTPGPLPQKKPEQPPVTSKTSPAQTPKPAPEQPKPAQEKPAAPAAETKEKEKAAPEPEAEDKKPARRPRKAKQPGKDETSPSSKAKSVPSSSSSSPDTSSPPPPGPTLLPQSPAPPPPSSKQTNRDPSPQEEEPRSNSVQARARVVFGASLAGPAERAERLARLRAESRVVAGVVVPPRPEEPDNCCMSGCVNCVWDRYRDDMEEWAAREAEAERRLAAEEAGGVVGVTEEVMDGVERGRGMELGVHDGDVDRGVVSVDDDGGGSVGNWELGSPPPPPSSSGGRIVKDFWDEELYKNVPVGIREFMKQEKRLKEKHRREGTVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTV3</accession>
    <name>Q2GTV3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001226527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTV3"/>
    <dbReference type="GeneID" id="4395320"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08601"/>
    <dbReference type="HOGENOM" id="CLU_1713032_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTV3"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="153" mass="16614" checksum="19430000D893E07B" modified="2006-03-21" version="1">MSRHQELPNYSIFNDCGFSVNCDHVLTCFGCRPQGGENDLNHLSLVFLQVIGQFAANLEKPLPPPAVKQPPNHRIVVPTSAAPATRPRGPASRAARATPSPRGTGTAPRQSPNYYAYDRQTNPTTRCTLQLFEGFDCDGMIGPSFSSDAKKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU50</accession>
    <name>Q2GU50_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_08504</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001226430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GU50"/>
    <dbReference type="GeneID" id="4395045"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08504"/>
    <dbReference type="eggNOG" id="KOG2886">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_504312_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GU50"/>
    <dbReference type="OrthoDB" id="1641132at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="TMEM205-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053009">
        <property type="entry name" value="Xanthocillin_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT PLANTS LEA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241:SF102">
        <property type="entry name" value="LD23009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM205-like" evidence="7">
        <location>
            <begin position="24"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="209"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ84490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="540" mass="60077" checksum="C1BE7741B49CC885" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV64</accession>
    <name>Q2GV64_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH myb-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_08140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225796.1">
        <property type="nucleotide sequence ID" value="XM_001225795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV64"/>
    <dbReference type="GeneID" id="4394142"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08140"/>
    <dbReference type="eggNOG" id="ENOG502QRT9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006238_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GV64"/>
    <dbReference type="OMA" id="QGIQPQG"/>
    <dbReference type="OrthoDB" id="3366990at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000137">
        <property type="entry name" value="MYB DNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013867">
        <property type="entry name" value="Telomere_rpt-bd_fac_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052833">
        <property type="entry name" value="Telomeric_DNA-bd_trans-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47807">
        <property type="entry name" value="PROTEIN TBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47807:SF1">
        <property type="entry name" value="PROTEIN TBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08558">
        <property type="entry name" value="TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="5">
        <location>
            <begin position="727"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="129"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="599"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="671"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="842"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="939"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="685"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="718"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="842"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="939"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="978"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1028"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1041"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1078"/>
            <end position="1088"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ86887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1120" mass="120324" checksum="FEB7F26AAC31013F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVM4</accession>
    <name>Q2GVM4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="12">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_07980</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 12">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="12"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225636.1">
        <property type="nucleotide sequence ID" value="XM_001225635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVM4"/>
    <dbReference type="FunCoup" id="Q2GVM4">
        <property type="interactions" value="1018"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GVM4"/>
    <dbReference type="GeneID" id="4393548"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07980"/>
    <dbReference type="eggNOG" id="KOG0657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030140_0_3_1"/>
    <dbReference type="InParanoid" id="Q2GVM4"/>
    <dbReference type="OMA" id="YGYTCNM"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000020">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 9 12" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="13">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="210"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="10">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ86727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="337" mass="36150" checksum="F098B77732736174" modified="2006-03-21" version="1">MAIKVGINGFGRIGRIVFRNAVEHDDVEIVAVNDPFIEPKYAEYMLKYDSTHGVFNGTIAVEGSDLVVNGKKVKFYTERDPAAIPWKETGAEYIVESTGVFTTTEKAGAHLKGGAKRVIISAPSADAPMYVMGVNEKTYDGSAQVISNASCTTNCLAPLAKVVNDKFGIVEGLMTTVHSYTATQKTVDGPSAKDWRGGRGAAQNIIPSSTGAAKAVGKVIPELNGKLTGMSFRVPTSNVSVVDLTCRLQKEASYDEIKAALKEASEGSLKGILGYTEDEIVSSDLNGNPNSSIFDAKAGISLNKNFVKLVSWYDNEWGYSRRVLDLLAYVAKVDASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVT2</accession>
    <name>Q2GVT2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_07922</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225578.1">
        <property type="nucleotide sequence ID" value="XM_001225577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVT2"/>
    <dbReference type="STRING" id="306901.Q2GVT2"/>
    <dbReference type="GeneID" id="4394485"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07922"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_1"/>
    <dbReference type="InParanoid" id="Q2GVT2"/>
    <dbReference type="OMA" id="MGLMMLE"/>
    <dbReference type="OrthoDB" id="256333at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08234">
        <property type="entry name" value="threonine_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050129">
        <property type="entry name" value="Zn_alcohol_dh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401:SF2">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="6">
        <location>
            <begin position="36"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="5">
        <location>
            <begin position="172"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ86669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="37610" checksum="87C99E7C5695A525" modified="2006-03-21" version="1">MGSLSKLPQEMKALRYNKPEDFEIVNVPLPVLREDDVLVKHIHEGEFIAEFPLIPGHETVGVVAAVGPKVTGFKVGDRVAADNSELCSHCFYCRRGEGLLCENWTGHGINLPGGFAEYCAYPQAKVFQIHNLTDIEATLIEPASCAAHGLDRIRPRLGSSVPNRFINFPSTQMLAQLLRQNGVTNLTLAAPGGLKMELAKQLDAADTYVELSRDDPAAQFEQIKRDNPHGFDIVVEATGSVRILEDAINYCRRGGTLVVYGVYAKAARVTWPPSKIFGDELRIIGSFSEVYMFPQTVEYLDSGKIKTKGIVNKVFKLEQFGEALESIRNKTAIKAAIVFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVZ4</accession>
    <name>Q2GVZ4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ras guanine nucleotide exchange factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_07860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225516.1">
        <property type="nucleotide sequence ID" value="XM_001225515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVZ4"/>
    <dbReference type="STRING" id="306901.Q2GVZ4"/>
    <dbReference type="GeneID" id="4393444"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07860"/>
    <dbReference type="eggNOG" id="KOG2378">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005431_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GVZ4"/>
    <dbReference type="OMA" id="HIAKWVA"/>
    <dbReference type="OrthoDB" id="28357at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF348">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="473"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="704"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="102"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="331"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="603"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="937"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="632"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ86607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="959" mass="105066" checksum="2A5A8CFD5E5A930B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWA0</accession>
    <name>Q2GWA0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_07754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225410.1">
        <property type="nucleotide sequence ID" value="XM_001225409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWA0"/>
    <dbReference type="GeneID" id="4393718"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07754"/>
    <dbReference type="HOGENOM" id="CLU_1777214_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWA0"/>
    <dbReference type="OrthoDB" id="10304047at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ86501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="146" mass="16112" checksum="F507A41CCB36E9D9" modified="2006-03-21" version="1">MSRIRVSIHQDQTKRYHLLGERSGASTERQEKRRMGGVARCCAVRKSNPEGRIACCEMRGAGAWATPIGTTTQIPTQSGGNGEPRLIGESRPLAGHVVDSSEALGKPGWLGLMALMTEQTAQILDCREVGEWQTGLQTHTRQWEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWG9</accession>
    <name>Q2GWG9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl hydrolase family 32 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_07685</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225341.1">
        <property type="nucleotide sequence ID" value="XM_001225340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWG9"/>
    <dbReference type="STRING" id="306901.Q2GWG9"/>
    <dbReference type="GeneID" id="4393610"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07685"/>
    <dbReference type="eggNOG" id="KOG0228">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2558106_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWG9"/>
    <dbReference type="OMA" id="KIGSAWH"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF1">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208514" description="Glycosyl hydrolase family 32 N-terminal domain-containing protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="5">
        <location>
            <begin position="33"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ86432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="82" mass="9368" checksum="808658A31DC2772A" modified="2006-03-21" version="1">MVISFAFALLLGLSLLRAAGAQTYNELYRPRYHFTPAKNWMNDPNGLLYHNGVYHLYYQYNPGGDTWGAMSWGHATTDDLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWN4</accession>
    <name>Q2GWN4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H/ACA ribonucleoprotein complex subunit NOP10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Nucleolar protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Nucleolar protein family A member 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">snoRNP protein NOP10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_07620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NOP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225276.1">
        <property type="nucleotide sequence ID" value="XM_001225275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWN4"/>
    <dbReference type="FunCoup" id="Q2GWN4">
        <property type="interactions" value="1078"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GWN4"/>
    <dbReference type="GeneID" id="4394283"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07620"/>
    <dbReference type="eggNOG" id="KOG3503">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184680_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GWN4"/>
    <dbReference type="OMA" id="HRIIIKK"/>
    <dbReference type="OrthoDB" id="13807at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904874">
        <property type="term" value="P:positive regulation of telomerase RNA localization to Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.40">
        <property type="entry name" value="H/ACA ribonucleoprotein complex, subunit Nop10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ86367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="60" mass="6994" checksum="E5B08214C26AF441" modified="2006-03-21" version="1">MHLMYLPESNGTGRRYTLKKVTDGQVTKSAHPARFSPDDKWSRHRIAIRKRFAVLLAQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWQ4</accession>
    <name>Q2GWQ4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_07600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225256.1">
        <property type="nucleotide sequence ID" value="XM_001225255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWQ4"/>
    <dbReference type="GeneID" id="4393497"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07600"/>
    <dbReference type="eggNOG" id="ENOG502SRM6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093550_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GWQ4"/>
    <dbReference type="OMA" id="CLKCALT"/>
    <dbReference type="OrthoDB" id="4160690at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208683" evidence="2">
        <location>
            <begin position="21"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ86347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="202" mass="19954" checksum="B093741846E4FB49" modified="2006-03-21" version="1">MQNLLMLSLFGLLAVSFANAALLENTQPLDHALILSRQAPGTPQYECHSNCGNALAGGRNPTHCTNATWTGYYDACLECALEFDIWRIYGTGVGGAASACGLSATPSPAAPASSAPTSVPAPTPTTETETGTETGTGTAVTTPPPPSSAATDAETANSGPSATSSVSTAGAAPGPLVVPSHGSTSSWVGVLVAGLAGLVGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX26</accession>
    <name>Q2GX26_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_07478</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225134.1">
        <property type="nucleotide sequence ID" value="XM_001225133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX26"/>
    <dbReference type="FunCoup" id="Q2GX26">
        <property type="interactions" value="271"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GX26"/>
    <dbReference type="GeneID" id="4393708"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07478"/>
    <dbReference type="eggNOG" id="KOG0682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_1"/>
    <dbReference type="InParanoid" id="Q2GX26"/>
    <dbReference type="OMA" id="GFPTTPM"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140157">
        <property type="term" value="P:ammonium import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="37"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ86225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="476" mass="50651" checksum="EAD58D7B512A8639" modified="2006-03-21" version="1">MSTGPLTTYTGVTGVADPGGDSMTEDLNLYYSAGDFAWIMTSSALVLLMVPGVGFFYSGLARRKSALALIWLSLISIAIAGFQWFFWGYSLTFSHTGSAFIGDLTNFGLMKVLAQPSVGSTKLPDILFCLYQGMFAAITPALAIGAAADRGRMLPCVVFIFIWATIVYDPIAYWTWNANGWSFQMGGLDFAGGTPVHISSGAAALAYSLMLGKRTGYTRVHGLPYRPHNVTHVVLGTVFLWVGWFGFNGGSALGANMRAVMACVVTHIAACVGGFTWCLLDYRLEKKWSTVGFCSGVISGLVAITPAAGYVPPWSAVVFGVVGGVVCNFATKLKFVLGIDDALDIFAEHGVGGIVGNLLTGLFAADYIARLDGSTKIDGGWVNQNYVQLGYQLADSVAGFSYSFVMTCVILFLMNLVPGLSLRASAAEEEIGLDDGELGEFAYDYVEITRHIDGAMTGMTGSPSHSIKGDVPEKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX50</accession>
    <name>Q2GX50_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225110.1">
        <property type="nucleotide sequence ID" value="XM_001225109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX50"/>
    <dbReference type="GeneID" id="4393654"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07454"/>
    <dbReference type="HOGENOM" id="CLU_1948584_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GX50"/>
    <dbReference type="OrthoDB" id="4589761at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="129" mass="13121" checksum="EF97784C42596A9D" modified="2006-03-21" version="1">MSSQTQKNVLLMLRQARAKPRNANITKTCGPPAPVTSVAALPMLYELEHGPPPAAAPAPTATLPVRTAATKTSATTTTKPTATKANASNTNTSTTRANATTNTTKASVTKTGATKTTGTGNGTKTNGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXD0</accession>
    <name>Q2GXD0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_07374</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225030.1">
        <property type="nucleotide sequence ID" value="XM_001225029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXD0"/>
    <dbReference type="FunCoup" id="Q2GXD0">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GXD0"/>
    <dbReference type="GeneID" id="4393628"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07374"/>
    <dbReference type="eggNOG" id="KOG2178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008831_10_2_1"/>
    <dbReference type="InParanoid" id="Q2GXD0"/>
    <dbReference type="OMA" id="IPKYQES"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000033">
        <property type="entry name" value="NADH kinase, variant 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000009">
        <property type="entry name" value="Poly(P)/ATP NAD kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF26">
        <property type="entry name" value="NADH KINASE POS5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ86121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="475" mass="51340" checksum="D9475B7A1ABACCD9" modified="2006-03-21" version="1">MVALRGSCWRLGGRSTAGGYRLFSVSAAHRKILDVAVLPDRTVPHYQQTKTSSLLSLHWPQPPQNILLMPKLHAPRVTTRAIEFAKHIYNNYPGLNLIFESHIANDIHETLPFPIYTTDPNDAPALFAKKIDLVTTMGGDGTILRAASLFSMHNSVPPILSFSMGTLGFLGEWKFSEYKRAWRECYMSGCSVAIEDLGDQHTSAAVPGTQPGAASSFVPLPGWDSVRGNGQCMGLSRTSKVLLRNRLRVGIYDSEGRNINEQLLPTTVAEPDLGTSSSGGGGSTGTNPTTNPPHLHAINEVSIDRGSHPHLAIIDIYVNGHFLTEAVADGILISTPTGSTAYSLSAGGSIVHPLVKSLLITPISPRSLSFRPLVLPLHTKVVLKLSKRNRGRELPVSIDGKRRVGVTIGMEVRVEGERLEKGREGWRGGVPCVIRASSTRGAEADGIAEDDDSWVGGLNGLLKFNYPFGEPPEEP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-24" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXM1</accession>
    <name>SEC16_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>COPII coat assembly protein SEC16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Protein transport protein SEC16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SEC16</name>
        <name type="ORF">CHGG_07283</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SEC16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224939.1">
        <property type="nucleotide sequence ID" value="XM_001224938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXM1"/>
    <dbReference type="FunCoup" id="Q2GXM1">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GXM1"/>
    <dbReference type="GeneID" id="4394275"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07283"/>
    <dbReference type="eggNOG" id="KOG1913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001147_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GXM1"/>
    <dbReference type="OMA" id="YKSPYDL"/>
    <dbReference type="OrthoDB" id="8918678at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09233">
        <property type="entry name" value="ACE1-Sec16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1030:FF:000008">
        <property type="entry name" value="Protein transport protein sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024340">
        <property type="entry name" value="Sec16_CCD"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="67" xmlns="https://uniprot.org/uniprot">
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                <person name="Untereiner W.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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                <person name="Untereiner W.A."/>
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            </authorList>
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        </source>
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            <dbReference type="EMBL" id="EAQ85729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
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        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
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        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
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        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="4">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ85579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="94" mass="10527" checksum="6B54F7AE72900F88" modified="2006-03-21" version="1">MVQLFDASFFNIKPVEAHSIDPPHRILLGVVYESLESAGQSIEALAKSQTGVYVGVMCDDFMQHVRRDIDIMPVYVATGTARSLISNRISYFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYZ4</accession>
    <name>Q2GYZ4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-xylosidase C-terminal Concanavalin A-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_05252</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224466.1">
        <property type="nucleotide sequence ID" value="XM_001224465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYZ4"/>
    <dbReference type="STRING" id="306901.Q2GYZ4"/>
    <dbReference type="GeneID" id="4392549"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05252"/>
    <dbReference type="eggNOG" id="ENOG502SM8A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016508_2_1_1"/>
    <dbReference type="InParanoid" id="Q2GYZ4"/>
    <dbReference type="OMA" id="KLTEAPH"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09000">
        <property type="entry name" value="GH43_SXA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF12">
        <property type="entry name" value="BETA-XYLOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="7">
        <location>
            <begin position="326"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ88633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="537" mass="61201" checksum="9680DDFE7AF724B5" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZA4</accession>
    <name>Q2GZA4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_05142</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224356.1">
        <property type="nucleotide sequence ID" value="XM_001224355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZA4"/>
    <dbReference type="STRING" id="306901.Q2GZA4"/>
    <dbReference type="GeneID" id="4392217"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05142"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_27_0_1"/>
    <dbReference type="InParanoid" id="Q2GZA4"/>
    <dbReference type="OMA" id="WEFIPFG"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ88523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="60003" checksum="9DDA73B4A00DE507" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZC6</accession>
    <name>Q2GZC6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224334.1">
        <property type="nucleotide sequence ID" value="XM_001224333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZC6"/>
    <dbReference type="STRING" id="306901.Q2GZC6"/>
    <dbReference type="ESTHER" id="chagb-q2gzc6">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="4392171"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05120"/>
    <dbReference type="eggNOG" id="ENOG502SJFK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_587927_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZC6"/>
    <dbReference type="OMA" id="WPINNIA"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="233"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="465" mass="50661" checksum="3880E3744B3A371C" modified="2006-03-21" version="1">MDLWTATHGYYKDHFSCMPAHFRTRNRGMTPSSISPDSRWPINNIADRGVFDSGLAAPSPRPHPVSGTIGVSRWSRASTLQGTPRPSLHQQAHRGVPQLSLLQLSPRSRRTSRSISSCFSASVPRGKPSRRQSKTGSPVEPSSTCTPQKKNEEHQNTKSHRITIHLPTKPPTTPAMAATTTIDVPHLGGIKAGYALSGGVYDPSKPTCVLINSMCTTVSLYRPQFSDASLTDALNLLAIEPLGHGATRCATEHFTYWDTAVMALQVMDKLGVDKAFALGTSQGGWMVARMALLAPERIQGLVLLGTSMDYESADSRSKGCWDPKTLLEPFYEKWCSPVPTPEFVVDDVWCGMVASLGFGAGGTAEMVAFWTETLKGVYTGDEGRKKLKMALACLLDRDGLCRRLIRPKGTEDAPFSTTVPAEQIKLFTSSKEATLTIIQGGHHYLNATNPKEVGASLLQMVNKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZI4</accession>
    <name>Q2GZI4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_05062</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224276.1">
        <property type="nucleotide sequence ID" value="XM_001224275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZI4"/>
    <dbReference type="STRING" id="306901.Q2GZI4"/>
    <dbReference type="GeneID" id="4392643"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05062"/>
    <dbReference type="eggNOG" id="ENOG502RJ18">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_717633_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZI4"/>
    <dbReference type="OrthoDB" id="5396311at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="139"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ88443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="385" mass="43717" checksum="B86B99F510912261" modified="2006-03-21" version="1">MDSNTWFAQIEQIMQAKKALAKQLEPSEKSLTPAIAHSTSRTPSSPEFLPNHPSSRPRSNHNNLVNLNWSKIHKFDIVSIAGSRDFMMAKKYTEENLQKAISAIRNGSMSVRKAAEEWGVPPSTIQSRIKKGVRPKGEYEATVLQQLSPTQEKHLAAWITIQEDLGVPVSHRQIRLFADRILQANGSSETVGNGWLPRFFKRHPEVKTKKAKRVDYKRIEGATTEVIRTWFEKLVLPAIEDMLPEHRGNMDELGVMEGMGTNGLCVGRQETRVAIAKSPENRIWITIIECITAAGQSLPPCPLKNSYRRYLNDIILQRNGLPLNKQDFIVAYARAREDLMYSKNVRSGWEASGLWPLNIEKPLASRFVDVGQPRQVSTPRKRRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZY3</accession>
    <name>Q2GZY3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribokinase</fullName>
            <shortName evidence="9">RK</shortName>
            <ecNumber evidence="9">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_04913</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="9"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224127.1">
        <property type="nucleotide sequence ID" value="XM_001224126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZY3"/>
    <dbReference type="FunCoup" id="Q2GZY3">
        <property type="interactions" value="957"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GZY3"/>
    <dbReference type="GeneID" id="4391559"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04913"/>
    <dbReference type="eggNOG" id="KOG2855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GZY3"/>
    <dbReference type="OMA" id="DIVLIQQ"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="10">
        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="28"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="235"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="267"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ88294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="320" mass="33051" checksum="2021455593B3809C" modified="2006-03-21" version="1">MDLVAYVPHHPLPGETLTADEFATSPGGKGANQAVACAKLSRARPTPGVDGGETASVAMVGCVGADGHGTQLQASLTSYGVSVSGVSARQGLKTGVALIIVDKPTGENRIVLSPGANHALQPADVQSLDLLRTPNPTNHHPRLPDLLIMQLEIPFATVLAALTAARAHNVPVLLNPAPARPLPAEAYLGLAHLVVNETEAAILGDVEERVLDEEAGLEAVAAGFVESGVQNVIITLGGRGVYYRARDGRSGLVPAERAVVVDTTAAGDTFVGRYALDVVAGGRGEGFDIEAAVRRANKAAAKTVEKAGAQDSIPWRDELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H027</accession>
    <name>Q2H027_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_04869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224083.1">
        <property type="nucleotide sequence ID" value="XM_001224082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H027"/>
    <dbReference type="GeneID" id="4392363"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04869"/>
    <dbReference type="HOGENOM" id="CLU_953166_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H027"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ88250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="292" mass="31439" checksum="A133F7A9A8689590" modified="2006-03-21" version="1">MQCIPVGEDAPGLPGTVAVSGFGGPPLLIFTALREEDGEGLTRGRVGWAYRSGLVLPEDGITSRDLEVAESLSFDVVTLSDLGSPWICACFCHRSFRLATAEAVHPEAPALLVNINRAPNVACRIVSPSHSRQEEIWYLAAGYPAPGSGVPASKDSNEAGSLQPLPQASDASLFEQPNPEAVDGLFSNRRRFLHSCAAVGESPLYGTHYFRILARSRIRGAASSGTRLQTRLGRWHPRGRRTGDTQRQETRKTGLLFGRLSGMLSNTNRSPVAVGHVPCHDQLLSGHVRPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0B3</accession>
    <name>Q2H0B3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_04783</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="5"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223997.1">
        <property type="nucleotide sequence ID" value="XM_001223996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0B3"/>
    <dbReference type="STRING" id="306901.Q2H0B3"/>
    <dbReference type="GeneID" id="4391532"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04783"/>
    <dbReference type="eggNOG" id="KOG2277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008947_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H0B3"/>
    <dbReference type="OMA" id="VELKCFG"/>
    <dbReference type="OrthoDB" id="407432at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050265">
        <property type="term" value="F:RNA uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="12">
        <location>
            <begin position="246"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="11">
        <location>
            <begin position="880"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="942"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1055"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="951"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="966"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1055"/>
            <end position="1073"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ88164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1123" mass="123936" checksum="E20E7946BA4798C5" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0I2</accession>
    <name>Q2H0I2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_04714</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223928.1">
        <property type="nucleotide sequence ID" value="XM_001223927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0I2"/>
    <dbReference type="STRING" id="306901.Q2H0I2"/>
    <dbReference type="GeneID" id="4392953"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04714"/>
    <dbReference type="eggNOG" id="ENOG502SWT1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008331_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H0I2"/>
    <dbReference type="OMA" id="TRGKCDP"/>
    <dbReference type="OrthoDB" id="3251668at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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</entry>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
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        </source>
    </reference>
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    <dbReference type="eggNOG" id="ENOG502S0GM">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_304608_0_0_1"/>
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    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="975" mass="103739" checksum="36E51D4D2A58DCA5" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2P3</accession>
    <name>Q2H2P3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_03953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223167.1">
        <property type="nucleotide sequence ID" value="XM_001223166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2P3"/>
    <dbReference type="GeneID" id="4392508"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03953"/>
    <dbReference type="HOGENOM" id="CLU_2084590_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2P3"/>
    <dbReference type="OrthoDB" id="10301618at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ87334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="117" mass="12223" checksum="A737786C4734C8E1" modified="2006-03-21" version="1">MVNGNPAVGHDGITSGAAAAAASPAFGVTTLRMSIPGCLPRMFEGRADEYERERGASAVGAMLCVTTLSNTRSSRRGRTAFLHPNTVPVKATLRGKCCDGAAQMSVLFRPDDNPLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2V0</accession>
    <name>Q2H2V0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.216</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">tRNA 2,2-dimethylguanosine-26 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA(guanine-26,N(2)-N(2)) methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA(m(2,2)G26)dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_03896</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223110.1">
        <property type="nucleotide sequence ID" value="XM_001223109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2V0"/>
    <dbReference type="FunCoup" id="Q2H2V0">
        <property type="interactions" value="1057"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H2V0"/>
    <dbReference type="GeneID" id="4391563"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03896"/>
    <dbReference type="eggNOG" id="KOG1253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010862_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H2V0"/>
    <dbReference type="OMA" id="HVTANDM"/>
    <dbReference type="OrthoDB" id="6349953at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.70:FF:000001">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="entry name" value="N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 12" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="87"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="609"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="661"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="630"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ87277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="681" mass="74048" checksum="CEC3C62E80E481DB" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H308</accession>
    <name>Q2H308_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_03838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223052.1">
        <property type="nucleotide sequence ID" value="XM_001223051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H308"/>
    <dbReference type="STRING" id="306901.Q2H308"/>
    <dbReference type="GeneID" id="4392569"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03838"/>
    <dbReference type="eggNOG" id="KOG2317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1053755_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H308"/>
    <dbReference type="OrthoDB" id="538640at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06154">
        <property type="entry name" value="YjgF_YER057c_UK114_like_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43857">
        <property type="entry name" value="BLR7761 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43857:SF1">
        <property type="entry name" value="YJGH FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ87219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="264" mass="29440" checksum="75E361AC016DFA04" modified="2006-03-21" version="1">MSDLDHYTYYLPHAPKPGVEANLPSYRFEIGFYATEDPNDPSIEGTVYEFREGGFWTDECCVRDKTYIFPHARIAYDVEIGEALVDRVFAGPGTTCHSWLKEAITVLGKYDFFVEGDLGLGDLEMDRRKVEQRLGVREGWLISSGSAFEAQIGYSRAVVSGDMVFVSGCTGYDYKTGAISDDVAEQAEQCMQNIAAALTEAGAGMGDVVRVQYTLPDRRDFEKTWPVLKKWFGDVRPAATMVQAGLMEEAMKIEIEVTAKKEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3E1</accession>
    <name>Q2H3E1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall protein PhiA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222919.1">
        <property type="nucleotide sequence ID" value="XM_001222918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3E1"/>
    <dbReference type="GeneID" id="4392414"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03705"/>
    <dbReference type="eggNOG" id="ENOG502SRG4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097238_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3E1"/>
    <dbReference type="OMA" id="WSIWADA"/>
    <dbReference type="OrthoDB" id="4093325at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208753" description="Cell wall protein PhiA" evidence="1">
        <location>
            <begin position="18"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="20642" checksum="C4ED532A0C60F179" modified="2006-03-21" version="1">MQLTSAFLSLFAVAASAAPASGSGKSCPASTRKFGIMALRSASPIHFATVGASQNGIALNLPANKLDAQCTDGKSRKDAIFYIKDEELYLYGKGDVVQQFLVDRSGMGQGVVRYFTKGPTDPSGRLEVKGWAVDENNNLTFKGTSLQACPNADGSWAIWLAGVTKPAGQEGCLPFTGRTITTTKPVKCTYSDYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3E8</accession>
    <name>Q2H3E8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222912.1">
        <property type="nucleotide sequence ID" value="XM_001222911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3E8"/>
    <dbReference type="GeneID" id="4391326"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06817"/>
    <dbReference type="eggNOG" id="ENOG502T2V4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1834933_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3E8"/>
    <dbReference type="OrthoDB" id="5151057at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15198" checksum="AC65B1829E0FC03F" modified="2006-03-21" version="1">MVKNGTKSGRARFRCAKGREYKPQANPETHESKRRKTSTQFTGCKFQLAARPLPDGRWAVKLPDGPAALHNHGWSYPTAFAGARARDSYEPGTAAPRASGRFIDGLDALDPDIEDDHDRALAAAEVAAHEDQEDAVALGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4B8</accession>
    <name>Q2H4B8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cenp-O kinetochore centromere component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_06497</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-O/MCM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222592.1">
        <property type="nucleotide sequence ID" value="XM_001222591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4B8"/>
    <dbReference type="STRING" id="306901.Q2H4B8"/>
    <dbReference type="GeneID" id="4390721"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06497"/>
    <dbReference type="eggNOG" id="ENOG502SCC4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042556_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4B8"/>
    <dbReference type="OMA" id="NHHRVAF"/>
    <dbReference type="OrthoDB" id="10050372at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031511">
        <property type="term" value="C:Mis6-Sim4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018464">
        <property type="entry name" value="CENP-O"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14582:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14582">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT MAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09496">
        <property type="entry name" value="CENP-O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ89878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="32096" checksum="0D6E3F9CBECD16F6" modified="2006-03-21" version="1">MSSNLDDEIEDLQAKISSLKKQLRIHTSTLITAPSTRQLLTEDTHASSSAPKTKHQQQQNSLLADSADQHEAHAQQCLYRACATLTTFRARDPDPCAVDAGAILGLRIEVISRARFLRPYYVLLNRPYLSADGSRRLRVHRHTLPACIPLAGLAARYLPPPAAATKEGSGGKKKQDLARFARAVRRDVVRYHNRLGVVADLRKAAGVGRDTGAEFGEEEQPNRLVNITAADSEVKQLTIEWADGRTGRLVMGNDGEIVKLVVLGENGRDREAARGLLGGATTAEDVVKRLAAASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4H4</accession>
    <name>Q2H4H4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_06441</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222536.1">
        <property type="nucleotide sequence ID" value="XM_001222535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4H4"/>
    <dbReference type="STRING" id="306901.Q2H4H4"/>
    <dbReference type="GeneID" id="4391450"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06441"/>
    <dbReference type="eggNOG" id="KOG2689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035996_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H4H4"/>
    <dbReference type="OMA" id="FEPNNTS"/>
    <dbReference type="OrthoDB" id="2445133at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="3">
        <location>
            <begin position="240"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ89822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="435" mass="47032" checksum="A3CE32C1385DCA71" modified="2006-03-21" version="1">MAFFEGTLQEGISAALQQSKSVMCFVTDGEAESQTWELQYFLDETLRDGQLKEYIAAGASKEDFMKRMKAALTPTESAPGQPLPSQAAALQPPVIQAPDSATSQPSHADESSSSSSGQATPPSTTNSRVQSMLTARAARVLEQKKKDEAEAKRQSAEKGKAKAEAGAPKKTDEQNRHAAALKKKQREAREERERILKAIEDDKVARKAQREEEAAARRMSMVSEKPDLATLTKVSSSAGRLSEHCAIQARLFDGSTIRHRFSSSDTLTDVRKWVDENRGDSKEAFSFKVLLTPLPSKTIDVTEEDKSLQALELAPSSTLILLRVPKFKVAYSASPGAAAGEPQGNIFQRLIAYFLAIITGFFSTVSAFVSSFLSTGGSSGALESSTAQATSSQSQAAADVARRRAGRIAGMDHAEGRRNDQQFYNGNSPRSDDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5D3</accession>
    <name>Q2H5D3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_06132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222227.1">
        <property type="nucleotide sequence ID" value="XM_001222226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5D3"/>
    <dbReference type="STRING" id="306901.Q2H5D3"/>
    <dbReference type="GeneID" id="4389970"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06132"/>
    <dbReference type="eggNOG" id="ENOG502S0KU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102662_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5D3"/>
    <dbReference type="OMA" id="HHQGGQN"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209288" evidence="2">
        <location>
            <begin position="22"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="239" mass="24435" checksum="0534CD7BEF67BE63" modified="2006-03-21" version="1">MHTTFGQFLVASVIAASAVSSLSFAPTGNEVARLVIPALALAAPAYGLPTLQARSPHHQGGGGGRGKGNGRNGARDLTDDDDDDDDDDEPELESRSPHHQGGGGGGRGKGNGRNNARDVETREPHHQGGGGGGRGNGNGRNNARDVELETREPHHQGGGGGNRGNGNGNGRNNARDVEELETREPHHQGGNGGNRGNGNNQNGGRDLEGLEIREPHHQGGGGNRGNGNGNGNGNGRGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5U4</accession>
    <name>Q2H5U4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fanconi-associated nuclease</fullName>
            <ecNumber evidence="8">3.1.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_05971</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
            <dbReference type="EC" id="3.1.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the FAN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.1" evidence="8"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222066.1">
        <property type="nucleotide sequence ID" value="XM_001222065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5U4"/>
    <dbReference type="STRING" id="306901.Q2H5U4"/>
    <dbReference type="GeneID" id="4390276"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05971"/>
    <dbReference type="eggNOG" id="KOG2143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005116_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H5U4"/>
    <dbReference type="OMA" id="ECRVESM"/>
    <dbReference type="OrthoDB" id="76364at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004528">
        <property type="term" value="F:phosphodiesterase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22326">
        <property type="entry name" value="FAN1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000009">
        <property type="entry name" value="Fanconi-associated nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033315">
        <property type="entry name" value="Fan1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049132">
        <property type="entry name" value="FAN1-like_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049126">
        <property type="entry name" value="FAN1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014883">
        <property type="entry name" value="VRR_NUC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749:SF4">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21170">
        <property type="entry name" value="FAN1_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08774">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00990">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VRR-NUC" evidence="10">
        <location>
            <begin position="643"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ89352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="773" mass="87934" checksum="BD201CC63E38572F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5Y2</accession>
    <name>Q2H5Y2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_05933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222028.1">
        <property type="nucleotide sequence ID" value="XM_001222027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5Y2"/>
    <dbReference type="GeneID" id="4390959"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05933"/>
    <dbReference type="HOGENOM" id="CLU_1272130_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5Y2"/>
    <dbReference type="OrthoDB" id="10322845at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="217" mass="24130" checksum="D5216F78FC639691" modified="2006-03-21" version="1">MKEKHEWMLYENERMWLPSQAAIEIVGHTAAGLVLELRRGPENARMVELGQKLLVVLRNLGLSEDEQAREAQLYEYHTMAARFSLDTPGACSAYGRKPLAGAEQSRLWKKLRSPYRSRGGLEGCNPPWREDGDRVTATGWLRVIFCLRVPPIGEAKRNMPSCSSRCATDLPREAAALPSQSVRGVGPASPAPTTVYASTLQMDVTWTRTFVASAESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5Y8</accession>
    <name>Q2H5Y8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222022.1">
        <property type="nucleotide sequence ID" value="XM_001222021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5Y8"/>
    <dbReference type="GeneID" id="4390995"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05927"/>
    <dbReference type="eggNOG" id="ENOG502SNMS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1767835_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5Y8"/>
    <dbReference type="OrthoDB" id="5397330at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="147" mass="15627" checksum="988B829741B4BDF8" modified="2006-03-21" version="1">MPIRNPFARRPGPATAHDESSRPGSAAGPTTTDAAHPGFERVDTVGSKASSAFSIRSSRPSQDTGEYKMSVAFTCHHPPLNEKKPPGRGATSRAPQPTTKAAVSPSAPATARSSTFSISRESFDSYRRSFVNTPLYTPPHTSPMVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H607</accession>
    <name>Q2H607_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_05908</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222003.1">
        <property type="nucleotide sequence ID" value="XM_001222002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H607"/>
    <dbReference type="STRING" id="306901.Q2H607"/>
    <dbReference type="GeneID" id="4391051"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05908"/>
    <dbReference type="eggNOG" id="KOG2069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025395_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H607"/>
    <dbReference type="OMA" id="DAMKDMT"/>
    <dbReference type="OrthoDB" id="1661054at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007255">
        <property type="entry name" value="COG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04124">
        <property type="entry name" value="Dor1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="344"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ89289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="471" mass="50465" checksum="6DA5C4FCBADD218F" modified="2006-03-21" version="1">MADSLYELLSPPGPSSSRALADPSSLEYLTTLASQPLSSLASSEPQALSQSSHGLLLSLQALSKKSHKQIIESASHHATLRTTLPALAASTAELRNAIPRLDSEAVRFSTTYNKSSDNEVLARRKKALLLSRNVERLVDVLELPTLLSSAITTAPVNYSSALDLNGHIRRLHSIYLNSPLMESISTQADEAMRTMAANLILSLKAPGLKLAASLRTISWLRRVLPDLEAASSSSSSPTTTTTIIQPSAHAKGRESQERVLGALFLVCRLATLMVMLEALEPLRELADQEQARQRALGSGNAWSGGQQTERYLKRYLEIFREQSFAIVSMFRSIFPATAAVTSDGPATSGGVGDGGVGGATTTATSQGGGSDPLEPMPSALATFPLYLVDMLLETLRVYLPTVRDQAARDSLLTQVLYCAGSLGRLGGDFGLFLATLDVGPEAEDEWVEVVKRHRALAGRLESIVGDQRRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6V7</accession>
    <name>Q2H6V7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase-like 2</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cyclophilin-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Cyclophilin-like protein Cyp-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">RING-type E3 ubiquitin transferase isomerase-like 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CHGG_05608</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 22 23">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221703.1">
        <property type="nucleotide sequence ID" value="XM_001221702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6V7"/>
    <dbReference type="STRING" id="306901.Q2H6V7"/>
    <dbReference type="GeneID" id="4390456"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05608"/>
    <dbReference type="eggNOG" id="KOG0883">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_7_0_1"/>
    <dbReference type="InParanoid" id="Q2H6V7"/>
    <dbReference type="OMA" id="NFIKHCA"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01923">
        <property type="entry name" value="cyclophilin_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16663">
        <property type="entry name" value="RING-Ubox_PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000079">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000014">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase cyp65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026951">
        <property type="entry name" value="PPIL2_U-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0697">Rotamase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="19">
        <location>
            <begin position="42"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="18">
        <location>
            <begin position="331"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="549"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00020592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EAQ88989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="597" mass="65752" checksum="E4C8A4974EFFE9A8" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6Y2</accession>
    <name>Q2H6Y2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4112 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221678.1">
        <property type="nucleotide sequence ID" value="XM_001221677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6Y2"/>
    <dbReference type="FunCoup" id="Q2H6Y2">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="GeneID" id="4390538"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05583"/>
    <dbReference type="eggNOG" id="ENOG502S45T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067862_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H6Y2"/>
    <dbReference type="OMA" id="TFRANTR"/>
    <dbReference type="OrthoDB" id="2103474at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="MEMBRANE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519:SF2">
        <property type="entry name" value="PH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="27581" checksum="FA7F50D7DB95D92D" modified="2006-03-21" version="1">MNAALKVLGKRALKNGTKSPNSENPYKHMVPVQKNGKIKMKEDERPTPPGLSENDKEILRHVRRKAYNWDQKFHCCCFGMRFGWSAILGLIPLIGDGLEVLMSLSLVRTASKVDGGLPKRIYLWMITYIIMDFAFGFIPVLGDFVDFTFRANTRNAWLLDSYLTEKGKVLLAGEIKDEGGGKSIPVPDELRPDDQDVEQGVESMRMVEPSSRTPTAVPPARTPTQKRAMPPPGRTLTGKARDPRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7B1</accession>
    <name>Q2H7B1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221549.1">
        <property type="nucleotide sequence ID" value="XM_001221548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7B1"/>
    <dbReference type="GeneID" id="4391227"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05454"/>
    <dbReference type="eggNOG" id="ENOG502SUNA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057716_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7B1"/>
    <dbReference type="OrthoDB" id="5291055at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847:SF1">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="357" mass="37950" checksum="9054132917638006" modified="2006-03-21" version="1">MTVTHSTKNSFRFGVEIELLLESPSRKYKTWHSLAMDLSKRLAKAGIPNRVDGSGDYSEWSIVREVTVQDPNGKSLYQYGIELISPIHTPATLPTLTKTLTQLFTTLTLTTTAIIPTPRCSSHIHISRSSTTSPPGLTPTDLAALPHQLSSRAGARHPHPARGGVRTAPHICGRSPTGTRTIPSLAALSLHSSLTRVDAAATAAGCMRAPGVGGGDPARPVVEVMNLVAKESRYGVVRGKRADFVRGKTCKWDFSGFLRAETTTGGGEVVDRGIAGTVEFRQPPGSVRAEEVVVWVTLAVAFVAGAVEVGMGLGVGGDVREEGGSLEELWGLLMKGREVVGWADLDVLEGLFLGVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7E9</accession>
    <name>Q2H7E9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_05416</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221511.1">
        <property type="nucleotide sequence ID" value="XM_001221510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7E9"/>
    <dbReference type="MEROPS" id="S53.007"/>
    <dbReference type="GeneID" id="4390144"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05416"/>
    <dbReference type="eggNOG" id="ENOG502QZ4I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013783_4_0_1"/>
    <dbReference type="InParanoid" id="Q2H7E9"/>
    <dbReference type="OMA" id="TCPWITS"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF19">
        <property type="entry name" value="SERINE PROTEASE AORO, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209328" description="Peptidase S53 domain-containing protein" evidence="9">
        <location>
            <begin position="23"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="10">
        <location>
            <begin position="223"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="556"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="597"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="598"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="616"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="618"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ88797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="639" mass="68047" checksum="D1AA276D0C0B397C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7L0</accession>
    <name>Q2H7L0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221450.1">
        <property type="nucleotide sequence ID" value="XM_001221449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7L0"/>
    <dbReference type="GeneID" id="4390389"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05355"/>
    <dbReference type="eggNOG" id="ENOG502QSYI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005049_6_1_1"/>
    <dbReference type="InParanoid" id="Q2H7L0"/>
    <dbReference type="OMA" id="EWENARM"/>
    <dbReference type="OrthoDB" id="3057168at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="19"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="372" mass="41343" checksum="09489A44EF4F2155" modified="2006-03-21" version="1">MATPLDPEHPSITRPGPPKRLILCCDGTWMDSLGSKGEPPSNVTRISRVFRRTCSDGTHQVINYFPGVGTANPIDRFMGGAFGMGLDQDIREVYNFICANYVDGDAIVLIGFSRGAFTARSVADLIASIGLLTPQGHDHFYAIFDDYENMGNPGRHTDYYVVPGLPKYDGSHGQAKIEWENARMRKYKQGLREKNTNISCTWTFTNTQISNKVENAFQALALDEPRYAFRPSLWECLPGSPTNLKQVWFPGNHGNVGGGWHDQQISDITLAWMCDQLSTLGLEFNFPRLTTFFHDTLRFSAAHPFPYAPGGSGNGRPFLPPIPKIPVDSLKRSLSKLLRGNKRASTASPKPKPTTTRMNLITTDGMSQRLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7T8</accession>
    <name>Q2H7T8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_05277</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221372.1">
        <property type="nucleotide sequence ID" value="XM_001221371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7T8"/>
    <dbReference type="ESTHER" id="chagb-q2h7t8">
        <property type="family name" value="Hormone-sensitive_lipase_like"/>
    </dbReference>
    <dbReference type="GeneID" id="4391277"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05277"/>
    <dbReference type="eggNOG" id="ENOG502SK9D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042179_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H7T8"/>
    <dbReference type="OMA" id="RETDWSV"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF18">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="121"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ88658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="386" mass="42786" checksum="C94CBE2CE683C25A" modified="2006-03-21" version="1">MGTKNPSEATGELSIWDPVRLFGFFLFRKTHELHWRQRLALSFLQAQRASFPTRYLRWLVRRVPTSEAIVRYAAKQGIPHKSITLDATTTTRDVTQGEIPDPTLHFLTPTSVNEDGNGSTLLYFHGGGFVNPLRGPAHMPFIMRCATACGAKQAAILEYSLAPEHPYPAQLVQCIAALRYLLDERDLRPNELVLAGDSAGGQLVGALLAHVLQPSPYAAPVKLNDKFRAALFVSPFVRLPPKAGNFDSYEINGRKDYIDRPQVDKFMAAFQGKDDEIWTDLCGGKGSDDVWNRVFARGPDGLVQKVMVTAGTSEILLDCCRVFAKTHVRAETVTASRDTDYREFEGKAMVLAECKGEVHVQVALDSAVGYDKGSMERAIMLWLASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8S5</accession>
    <name>Q2H8S5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosome subunit biogenesis protein NIP7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_03379</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with pre-ribosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NIP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229895.1">
        <property type="nucleotide sequence ID" value="XM_001229894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8S5"/>
    <dbReference type="FunCoup" id="Q2H8S5">
        <property type="interactions" value="930"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H8S5"/>
    <dbReference type="GeneID" id="4389294"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03379"/>
    <dbReference type="eggNOG" id="KOG3492">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097217_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8S5"/>
    <dbReference type="OMA" id="LISMGTC"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.220:FF:000001">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="8">
        <location>
            <begin position="96"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ91444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="183" mass="20267" checksum="B3123C75689A81EF" modified="2006-03-21" version="1">MRPLTDEEMKTVLDKLANYMSDLKSLIAPLEDGDRYVFRLNHSRVYYVKLSIANLATSISRDALLSLGTCLGKVTKTGKFRLHITALPIIAAGARHKIWVKDNGAQPFLYGSNVVKAHVGRWSEDCPEHQGCVVYSMADVPLGFGVTARSTAEARRLDPTGIVCFRQSDCGEYLRDEDTLFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H963</accession>
    <name>Q2H963_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229757.1">
        <property type="nucleotide sequence ID" value="XM_001229756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H963"/>
    <dbReference type="GeneID" id="4388616"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03241"/>
    <dbReference type="HOGENOM" id="CLU_3124903_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H963"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="50" mass="5416" checksum="85A4A8EA68C2CD16" modified="2006-03-21" version="1">MVLANRGFALSPSCHPSNLLANVFERNSLPPTQSSSDCLGSAPERMRRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H972</accession>
    <name>Q2H972_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_03232</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229748.1">
        <property type="nucleotide sequence ID" value="XM_001229747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H972"/>
    <dbReference type="STRING" id="306901.Q2H972"/>
    <dbReference type="GeneID" id="4388908"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03232"/>
    <dbReference type="eggNOG" id="KOG2167">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004747_7_0_1"/>
    <dbReference type="InParanoid" id="Q2H972"/>
    <dbReference type="OMA" id="KSEFEPR"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043494">
        <property type="term" value="C:CLRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140720">
        <property type="term" value="C:subtelomeric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033621">
        <property type="term" value="P:nuclear mRNA surveillance of meiosis-specific transcripts"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140727">
        <property type="term" value="P:siRNA-mediated pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000031">
        <property type="entry name" value="Ubiquitin ligase subunit CulD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="6">
        <location>
            <begin position="320"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ91297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="709" mass="78722" checksum="74DD87487566F4FA" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9N6</accession>
    <name>Q2H9N6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_03068</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229584.1">
        <property type="nucleotide sequence ID" value="XM_001229583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9N6"/>
    <dbReference type="STRING" id="306901.Q2H9N6"/>
    <dbReference type="GeneID" id="4388785"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03068"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030044_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H9N6"/>
    <dbReference type="OMA" id="WTTVPNK"/>
    <dbReference type="OrthoDB" id="48651at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF11">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208976" description="RRM domain-containing protein" evidence="4">
        <location>
            <begin position="32"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="49"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="118"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="317"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="432"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="462"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ91133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="508" mass="54644" checksum="1151C11F165145A5" modified="2006-03-21" version="1">MTSYGGSTDRGMSRRHWQLSVLMINFRLLLQVTTRSATIYPRSCRPSRRILRISATCRYDATVETVTEFFEDCNIVNVRIIEDREQNRPKGFAYAEFGDLEGLKTALTRDGQNFQGRTIRVKVADPPRGGGFGSSEGMRDLDWGAKRGPLADLPGRGGDRRGGDFGERRREYQPNDDGKVRDFNSWERRGPLSPRAPPERPESREGSRSRNMESRSESFRGGNPESVARSLGPGCRKGFQLGGTTCGPDSSVKSPGESREGSEAPPSPAPSAALPAGRPRLNLTKRTVSEATDAAATSTPGDAKASPFGAARPIDTATREREIEEKRLKLAKEAEEKAKEEKLAKEAAAKEAAEKAAEEKAAAEEAAAKAKEEKEASAAEAKAAPEEGATNEATTEQKLPVRTREAREPPKSRAVESGNWRTTSGEQRAPSRGGGNVPSGPRRGGPARGPRDNGRPPRANGSGPTPQQPLSPTSEQAPPTPTVDEDGWTTVAAPIKGRRGGSGRPLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9Z5</accession>
    <name>Q2H9Z5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_02959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2005-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Giovannoni S.J."/>
                <person name="Cho J.-C."/>
                <person name="Ferriera S."/>
                <person name="Johnson J."/>
                <person name="Kravitz S."/>
                <person name="Halpern A."/>
                <person name="Remington K."/>
                <person name="Beeson K."/>
                <person name="Tran B."/>
                <person name="Rogers Y.-H."/>
                <person name="Friedman R."/>
                <person name="Venter J.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 148.51</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2006-02" db="EMBL/GenBank/DDBJ databases">
            <title>Annotation of the Chaetomium globosum CBS 148.51 Genome.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Birren B."/>
                <person name="Lander E."/>
                <person name="Galagan J."/>
                <person name="Devon K."/>
                <person name="Nusbaum C."/>
                <person name="Ma L.-J."/>
                <person name="Jaffe D."/>
                <person name="Butler J."/>
                <person name="Alvarez P."/>
                <person name="Gnerre S."/>
                <person name="Grabherr M."/>
                <person name="Kleber M."/>
                <person name="Mauceli E."/>
                <person name="Brockman W."/>
                <person name="Rounsley S."/>
                <person name="Young S."/>
                <person name="LaButti K."/>
                <person name="Pushparaj V."/>
                <person name="DeCaprio D."/>
                <person name="Crawford M."/>
                <person name="Koehrsen M."/>
                <person name="Engels R."/>
                <person name="Montgomery P."/>
                <person name="Pearson M."/>
                <person name="Howarth C."/>
                <person name="Kodira C."/>
                <person name="Yandava C."/>
                <person name="Zeng Q."/>
                <person name="Alvarado L."/>
                <person name="Oleary S."/>
                <person name="Untereiner W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 148.51</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229475.1">
        <property type="nucleotide sequence ID" value="XM_001229474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9Z5"/>
    <dbReference type="GeneID" id="4389753"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02959"/>
    <dbReference type="HOGENOM" id="CLU_1170528_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9Z5"/>
    <dbReference type="OrthoDB" id="10445674at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208984" evidence="2">
        <location>
            <begin position="20"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="237" mass="26187" checksum="F8D1748DF9A08C6A" modified="2006-03-21" version="1">MTRAWRWLATLRPLLVLHAALLRRWKGCLLSFLSGTTPGATPLFETSPSLQIKPLAHGFHTLVTPRLAAFGRVFEIPDAELWRRGWERDKTSQAMSAARQPPKWTGRERRTPSPRACYRIEALPACVFYAVETDLEFFSNAYGSVQELKQLHPRQPSTSGPECLRPLPVRVSARLEASVVRDQSPPSSNSPVGTACVMSTPHDIGGHLYQALALHSSGLAITPYLSRPLAETIRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAN4</accession>
    <name>Q2HAN4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Autophagy-related protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_02720</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Preautophagosomal structure membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <text evidence="7">During pexophagy, accumulates in the vacuolar membrane region, where the peroxisomes contact the vacuole.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATG11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229236.1">
        <property type="nucleotide sequence ID" value="XM_001229235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAN4"/>
    <dbReference type="STRING" id="306901.Q2HAN4"/>
    <dbReference type="GeneID" id="4389423"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02720"/>
    <dbReference type="eggNOG" id="ENOG502QVZE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002803_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HAN4"/>
    <dbReference type="OMA" id="GLRWYLI"/>
    <dbReference type="OrthoDB" id="447953at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903599">
        <property type="term" value="P:positive regulation of autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040040">
        <property type="entry name" value="ATG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019460">
        <property type="entry name" value="Atg11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222:SF1">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10377">
        <property type="entry name" value="ATG11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="10">
        <location>
            <begin position="182"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy-related protein 11 C-terminal" evidence="11">
        <location>
            <begin position="959"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="23"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1056"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1128"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1184"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="488"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="564"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="752"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="836"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1133"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1156"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1226"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1245"/>
            <end position="1259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ90785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1265" mass="141529" checksum="0FFD896251D31F35" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBQ7</accession>
    <name>Q2HBQ7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calcofluor white hypersensitive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_02347</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228863.1">
        <property type="nucleotide sequence ID" value="XM_001228862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBQ7"/>
    <dbReference type="FunCoup" id="Q2HBQ7">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HBQ7"/>
    <dbReference type="GeneID" id="4388366"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02347"/>
    <dbReference type="eggNOG" id="KOG3979">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009808_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HBQ7"/>
    <dbReference type="OMA" id="CVWYFPL"/>
    <dbReference type="OrthoDB" id="68581at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000031">
        <property type="entry name" value="Calcofluor white hypersensitive protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057315">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051916">
        <property type="entry name" value="GPI-anchor_lipid_remodeler"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053912">
        <property type="entry name" value="PGAP2IP_TM_1nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053911">
        <property type="entry name" value="PGAP2IP_TM_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859">
        <property type="entry name" value="CALCOFLUOR WHITE HYPERSENSITIVE PROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859:SF1">
        <property type="entry name" value="PGAP2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23022">
        <property type="entry name" value="6TM_1st_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23021">
        <property type="entry name" value="6TM_2nd_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23226">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="459"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="500"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="578"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="613"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="652"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="2">
        <location>
            <begin position="20"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP first transmembrane" evidence="4">
        <location>
            <begin position="284"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP second transmembrane" evidence="3">
        <location>
            <begin position="456"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP C-terminal nuclease-like" evidence="5">
        <location>
            <begin position="685"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ90412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="963" mass="106669" checksum="72C67E9EDAABC2AE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCA4</accession>
    <name>Q2HCA4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Arabinan endo-1,5-alpha-L-arabinosidase</fullName>
            <ecNumber evidence="4 7">3.2.1.99</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_02150</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Endohydrolysis of (1-&gt;5)-alpha-arabinofuranosidic linkages in (1-&gt;5)-arabinans.</text>
            <dbReference type="EC" id="3.2.1.99"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.99" evidence="4 7"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228666.1">
        <property type="nucleotide sequence ID" value="XM_001228665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCA4"/>
    <dbReference type="STRING" id="306901.Q2HCA4"/>
    <dbReference type="GeneID" id="4389846"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02150"/>
    <dbReference type="eggNOG" id="ENOG502QTQG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009397_5_0_1"/>
    <dbReference type="InParanoid" id="Q2HCA4"/>
    <dbReference type="OMA" id="GHLWAPD"/>
    <dbReference type="OrthoDB" id="195678at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046558">
        <property type="term" value="F:arabinan endo-1,5-alpha-L-arabinosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18831">
        <property type="entry name" value="GH43_AnAbnA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016840">
        <property type="entry name" value="Glyco_hydro_43_endo_a_Ara-ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF3">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026534">
        <property type="entry name" value="Endo_alpha-L-arabinosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209121" description="Arabinan endo-1,5-alpha-L-arabinosidase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="9">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR026534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ90215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="321" mass="34281" checksum="CDBC5D92D13DB2FF" modified="2006-03-21" version="1">MVGLSDILGAVALLPALVSAYALPEACSGICNNSHDPSIIRRADGTYFRFSTGGRIAIHTAPSLSGPWTYKGAALPGGSSINLPGNQDLWAPDVAQVGNQYYLYYSVSTFGVQNSAIGIARSSSLDAGTWTDLGSTGVVSSAGLPYNAIDGNLVNEPGTSNYFLTFGSFWNGIHRVRMTPTKSNGAAYQVAFDPNDTAMEGPTVFKNGDFYYLFFSKGTCCGYDKNRPAAGKEYRILACRSSSPVGPFVDRDGRSCRSGGGTVVLQSHNWVYGPGGQGAYQDPTNGPVLYYHYVDTRIGFGDGQKKFGWNRINFSSGWPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCN6</accession>
    <name>Q2HCN6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_02018</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221239.1">
        <property type="nucleotide sequence ID" value="XM_001221238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCN6"/>
    <dbReference type="STRING" id="306901.Q2HCN6"/>
    <dbReference type="GeneID" id="4388315"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02018"/>
    <dbReference type="eggNOG" id="KOG1558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027089_5_0_1"/>
    <dbReference type="InParanoid" id="Q2HCN6"/>
    <dbReference type="OMA" id="VENTCER"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209129" evidence="6">
        <location>
            <begin position="28"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ93783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="458" mass="48475" checksum="EC0D903D1798D8AC" modified="2006-03-21" version="1">MARLSSPLRTAVLYGLLAATGVPIAQAVSPTAQPVYQRAPHVDPSVSDPNPATITAVSKCHEHGTVQYCMAPTGEVQVIAAAQTDGPTPTTQDTPTSITVVSECHTHSTLLYCMGGTVEYEVHTTITATQDIPPAFTGCHSHGTETFCIGPNGDEVELHVAGEEEGGQDESHPEGQDCHFHAGIEHCTGVENTCERVDRDYNINLRVGLLFAMLATSSIGVFTPILMASYVSPNHPVFTVLRQFGTGVIISTAFVHLYTHANLMFTNECLGELEYEATAAAILMAGIFLSFLVEYCGSRLVQWHEAKAKPSTVEAVGHGHAAPEARTDMVNIAVLEAGVIFHSLLIGLTLVVAGDTFFLTLFALLLALAFAIVTPLGMGIGIGVLQNFNGNDPATIIAIGTLDAFSAGILVWVGVVEMWAHDWMLGGEMTRAGPVRTVLGLGALVVGMAVMSLLGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCT3</accession>
    <name>Q2HCT3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_01971</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221192.1">
        <property type="nucleotide sequence ID" value="XM_001221191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCT3"/>
    <dbReference type="STRING" id="306901.Q2HCT3"/>
    <dbReference type="GeneID" id="4386286"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01971"/>
    <dbReference type="eggNOG" id="KOG2248">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_604105_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCT3"/>
    <dbReference type="OMA" id="VEPHEPI"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06137">
        <property type="entry name" value="DEDDh_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF114">
        <property type="entry name" value="EXONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="195"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ93736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="453" mass="49137" checksum="D5D71BF3AF04CB94" modified="2006-03-21" version="1">MPTANHATESSNLNRAFSSTRKIPRLTSNFPESPRGQFILIQRHGQFHRLASTLRRNNDLIFPSRLFNIPAHSALPPLTAPSPPQGQRNPPFSITPPSATIPQPPQATPTPTPATTGTAPAPPRLTHRGITYTTLTPAQQTALHPLLLARCHTRKRLSIEGYDLDPRPPATIAPPPRDPHNNNNPPRHHHTAAAAAVVLDCEMAGTSAGDYPIAVSVVDFFTGAVLVDALVRPGAGVVVQDWRSGITGIGAARIADAGRAGSGDGEPLAGREGAREAVLRFVDGETVVVGQAVRFDLRALGIVHGRVVDSAVLAAEASGRFGGVAGGGGVHRKIKWWAGLEELCRELLGMRIRGGEGQSHDSLEDVLATRELVLWCLENPDQLKAWAAMRWGVKAKKGWRTPQGRKGDSGRNKNWWTWAQRTYGHDSDDDQMLRWEDVVDYACWPKSPPDWSD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-05" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCV1</accession>
    <name>PESC_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pescadillo homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleolar protein 7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">NOP7</name>
        <name type="ORF">CHGG_01953</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. The complex is held together by ERB1, which interacts with NOP7 via its N-terminal domain and with YTM1 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pescadillo family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221174.1">
        <property type="nucleotide sequence ID" value="XM_001221173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCV1"/>
    <dbReference type="SMR" id="Q2HCV1"/>
    <dbReference type="FunCoup" id="Q2HCV1">
        <property type="interactions" value="1132"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HCV1"/>
    <dbReference type="GeneID" id="4387482"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01953"/>
    <dbReference type="eggNOG" id="KOG2481">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019619_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HCV1"/>
    <dbReference type="OMA" id="QKVTWIV"/>
    <dbReference type="OrthoDB" id="10264910at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17709">
        <property type="entry name" value="BRCT_pescadillo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03028">
        <property type="entry name" value="Pescadillo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
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            <begin position="1"/>
            <end position="660"/>
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            <end position="476"/>
        </location>
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        </location>
    </feature>
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            <begin position="471"/>
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        </location>
    </feature>
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        <location>
            <begin position="501"/>
            <end position="659"/>
        </location>
    </feature>
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        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
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        <location>
            <begin position="504"/>
            <end position="566"/>
        </location>
    </feature>
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        <location>
            <begin position="584"/>
            <end position="619"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="660" mass="74742" checksum="9F5EFF1585F34BE7" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HD36</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">CHGG_01868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </feature>
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            <begin position="65"/>
            <end position="110"/>
        </location>
    </feature>
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        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="110" mass="11566" checksum="5BF6598FC5589870" modified="2006-03-21" version="1">MAQDARGGEVPGLQGGDRGAKVGSQHLVRASGRLKDKSRPSEGGGGCVGRASLWLRLVWPGLRRCGAGRSRRPDRSKCGFPSDGREYGRTTDSGGTITARTNVAMDTGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDF8</accession>
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        <recommendedName>
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        </recommendedName>
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    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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    </organism>
    <reference evidence="4" key="1">
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="eggNOG" id="KOG1426">
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    <dbReference type="Proteomes" id="UP000001056">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="233"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="382"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="485"/>
            <end position="614"/>
        </location>
    </feature>
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        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
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        <location>
            <begin position="569"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="589"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93511.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="672" mass="75099" checksum="0C764624D0197B18" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDJ2</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CHGG_01712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
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        <lineage>
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            <taxon>Sordariomycetes</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001220932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDJ2"/>
    <dbReference type="GeneID" id="4386990"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01712"/>
    <dbReference type="eggNOG" id="ENOG502RB1B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_606905_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HDJ2"/>
    <dbReference type="OrthoDB" id="5389892at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF1">
        <property type="entry name" value="PAL1 CELL MORPHOLOGY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
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        <location>
            <begin position="192"/>
            <end position="238"/>
        </location>
    </feature>
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        <location>
            <begin position="268"/>
            <end position="344"/>
        </location>
    </feature>
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        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <begin position="423"/>
            <end position="439"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="451" mass="49936" checksum="269436AD144240DF" modified="2006-03-21" version="1">MAAAGGDQNRHRRRANSHQPSEAKEGGGKDTLPRRSGSLRERYPGDMSHRPLAMLTKQHRAADRAPHLHNHRRQQPSDTIDTLDITGPVPSVYHHSGPFDATLKSRNTNKKYSPVEAVKETNAKALKATPPEYIQDSLVKHMPLQGTAVVPPGMKDMAGRTMHYEEGADMMREEDAAGGAYKRWEHIRYHPDDFKGKGEPSFSHDQARRAKQPTTDSTGTVSYEMQPTTTASSSLLSRDYDHNDDYGYGHGKAEEGVMVAAVRRRSMTGLDRSASTKRQQPSTPTQSSLNHLFPLSSPPPIYPPLNPSPLPIARPPSHGAPPDRVELPAQHPPQKGPTPPTTARVEDIDDAFQCSLPVTIEYPDLTSASRRAIWGNFLRGSTIKSSLTDKDIHELAELKLNGRQIKNVLKTAQLLAAPEEERDAGPEVYRDNSDHREGSGKVPLQQMMHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDZ4</accession>
    <name>Q2HDZ4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01560</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Soil fungus</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001220780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDZ4"/>
    <dbReference type="GeneID" id="4387528"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01560"/>
    <dbReference type="eggNOG" id="ENOG502T5YW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1421267_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HDZ4"/>
    <dbReference type="OrthoDB" id="4576988at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="191" mass="20853" checksum="64FFAE3D0B3C1035" modified="2006-03-21" version="1">MLIPQPPRPKTAAPVPKPQIHTHKNHHTYNGTLKLPQSTHVRIIPEPPADNHNNNNNSPKPDPRTPRYVITLHYAHNRACELYRTAHDLDILRRALGVPAHPKPTPPPPKATTGISNLGSNIQTAPTTTTTGEGRQAQVQAPGRKSRNPLPASAPAPAPARAPPPSDSAIMRGRRRLDEDCIPRDWGTQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HE66</accession>
    <name>Q2HE66_CHAGB</name>
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        <recommendedName>
            <fullName evidence="5">Cell division control protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">CHGG_01488</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CDC6/cdc18 family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="4387466"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01488"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012774_2_0_1"/>
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    <dbReference type="OMA" id="LFEWSLH"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="AAA_16"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
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        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001767">
        <property type="entry name" value="Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="175"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="490"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ93253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="632" mass="69013" checksum="CE29A1DA1854AA71" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HE77</accession>
    <name>Q2HE77_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_01477</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220698.1">
        <property type="nucleotide sequence ID" value="XM_001220697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HE77"/>
    <dbReference type="STRING" id="306901.Q2HE77"/>
    <dbReference type="GeneID" id="4386188"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01477"/>
    <dbReference type="eggNOG" id="KOG3009">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012201_3_0_1"/>
    <dbReference type="InParanoid" id="Q2HE77"/>
    <dbReference type="OMA" id="FNCIIAT"/>
    <dbReference type="OrthoDB" id="198885at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01941">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="entry name" value="Indigoidine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
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        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="6">
        <location>
            <begin position="246"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="6">
        <location>
            <begin position="573"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ93242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="641" mass="67705" checksum="7D14DDB207A652CD" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEV9</accession>
    <name>Q2HEV9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short-chain dehydrogenase/reductase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220466.1">
        <property type="nucleotide sequence ID" value="XM_001220465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEV9"/>
    <dbReference type="STRING" id="306901.Q2HEV9"/>
    <dbReference type="GeneID" id="4387563"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01245"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_4_1"/>
    <dbReference type="InParanoid" id="Q2HEV9"/>
    <dbReference type="OMA" id="FWHHDIL"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF22">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE PHMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
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    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="38296" checksum="93999A73A150D23B" modified="2006-03-21" version="1">MSDPNIITARKYPEGGGPPPGLGQRSAMRWAVKHPPADPTVSFAGKTVLVTGANTGIGFEAAVKYSALGADLLILGVRNLEKGEDTKKRILARTHRQSDTIAIAPVDLATFASVRTFVTTVEKLTPRLDVALLNAGLGNPKFEAAPSGWEMGFQVNVLSTTLMAILLLPLLRRTASATGKPPHLTLTNSHGHGMVEREWFAKSGSLVKAVAERDGWNADRSYLMLKLIACAVAETLAGVTRERGSTPGTPEVIVNLACPGLCKTDLGRKFSVASHIFMAPFLAIFARTAEQGSRTLVSATALGPESHAGFWTHDVLYPYGKLVEDKDLMQQAWHDVLEIVKEGNPDVDVQRILDGGD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-11-02" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEW1</accession>
    <name>CHEG_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome P450 monooxygenase cheG</fullName>
            <ecNumber evidence="9">1.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Chaetoglobosin A biosynthesis cluster protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cheG</name>
        <name type="ORF">CHGG_01243</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2013" name="J. Am. Chem. Soc." volume="135" first="7371" last="7377">
            <title>Combinatorial generation of complexity by redox enzymes in the chaetoglobosin A biosynthesis.</title>
            <authorList>
                <person name="Ishiuchi K."/>
                <person name="Nakazawa T."/>
                <person name="Yagishita F."/>
                <person name="Mino T."/>
                <person name="Noguchi H."/>
                <person name="Hotta K."/>
                <person name="Watanabe K."/>
            </authorList>
            <dbReference type="PubMed" id="23611317"/>
            <dbReference type="DOI" id="10.1021/ja402828w"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2021" name="Fungal Biol." volume="125" first="201" last="210">
            <title>Functional analysis of a chaetoglobosin A biosynthetic regulator in Chaetomium globosum.</title>
            <authorList>
                <person name="Cheng M."/>
                <person name="Zhao S."/>
                <person name="Liu H."/>
                <person name="Liu Y."/>
                <person name="Lin C."/>
                <person name="Song J."/>
                <person name="Thawai C."/>
                <person name="Charoensettasilp S."/>
                <person name="Yang Q."/>
            </authorList>
            <dbReference type="PubMed" id="33622536"/>
            <dbReference type="DOI" id="10.1016/j.funbio.2020.10.010"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="5 6 10">Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of chaetoglobosin A which has a unique inhibitory activity against actin polymerization in mammalian cells (PubMed:23611317, PubMed:33622536). Chaetoglobosin A and its intermediates are involved in the morphological differentiation of C.globosum (PubMed:33622536). The first step of the pathway is the synthesis of prochaetoglobosin I via condensation of one acetyl-CoA, 8 malonyl-CoA, and a L-tryptophan molecule by the PKS-NRPS hybrid synthetase cheA, followed by reduction of backbone double bond to install desired geometry by the enoyl reductase cheB (PubMed:23611317). Further multiple oxidation steps performed by the cytochrome P450 monooxygenases cheE and cheG, as well as by the FAD-linked oxidoreductase cheF, lead to the formation of chaetoglobosin A (PubMed:23611317). Depending on the order of action of these reductases, distinct intermediates can be identified (PubMed:23611317). Within the pathway, the cytochrome P450 monooxygenase cheE catalyzes a stereospecific epoxidation on prochaetoglobosin I, cytoglobosin D, and chaetoglobosin J intermediates (PubMed:23611317). The FAD-linked oxidoreductase cheF performs dehydrogenation of the C-20 hydroxyl groups in the 20-dihyrochaetoglobosin A and cytoglobosin D intermediates (PubMed:23611317). Finally, the cytochrome P450 monooxygenase cheG can catalyze the stereospecific dihydroxylation of prochaetoglobosin I and prochaetoglobosin IV at C-19 and C-20, respectively (PubMed:23611317). The Diels-Alderase cheD may play a role in the post-PKS-NRPS biosynthetic steps catalyzing Diels-Alder cyclization.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="6">Expression is positively regulated by the cluster-specific transcription factor cheR that binds directly to an asymmetric direct repeat present in the promoter.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5">Impairs the production of chaetoglobosin A but leads to the accumulation of prochaetoglobosin IV (PubMed:23611317).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220464.1">
        <property type="nucleotide sequence ID" value="XM_001220463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEW1"/>
    <dbReference type="SMR" id="Q2HEW1"/>
    <dbReference type="STRING" id="306901.Q2HEW1"/>
    <dbReference type="GlyCosmos" id="Q2HEW1">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="GeneID" id="4387649"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01243"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022195_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HEW1"/>
    <dbReference type="OMA" id="NRFKFAN"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="BioCyc" id="MetaCyc:MONOMER-19103"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF6">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AN1598-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0349">Heme</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0503">Monooxygenase</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000438245" description="Cytochrome P450 monooxygenase cheG">
        <location>
            <begin position="1"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="308"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P04798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="23611317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="33622536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="33622536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <evidence type="ECO:0000305" key="9">
        <source>
            <dbReference type="PubMed" id="23611317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="10">
        <source>
            <dbReference type="PubMed" id="33622536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ93008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="340" mass="37995" checksum="782A629292BF0FEF" modified="2006-03-21" version="1">MFPALQKIVVSTNASPLVGRELASNSTWIWHVERLPMLLGIPTVILSLTPAVLRLLIKPLLFVPIRYSSFVLTRLITPVLKEDMLEFESTADKKSPAGPKAKGKLALTSWLLSRYPASLKDRMSQLIRDYLAITFESTPSTSGVLFYILIELAAAPELAEAVRRELREVAPNGELPSTHLNELKVMDSVMRESARVNPFSHLVLYRKLLRPLKLEGCPELPAGCFICVDAHHIDFSPQLWENPERFDGLRHYRARQKPENGNRFKFANLGSDAPGWGDGPQACPGRMFADNTIKIILAHILTHYDLELPPGQGKPEKGSMPNGSMSPDTKAKVLFRSRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFJ0</accession>
    <name>Q2HFJ0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Something about silencing protein 4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220235.1">
        <property type="nucleotide sequence ID" value="XM_001220234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFJ0"/>
    <dbReference type="STRING" id="306901.Q2HFJ0"/>
    <dbReference type="GeneID" id="4388051"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01014"/>
    <dbReference type="eggNOG" id="ENOG502RYH0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011914_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HFJ0"/>
    <dbReference type="OMA" id="PEAIDSC"/>
    <dbReference type="OrthoDB" id="1938992at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033255">
        <property type="term" value="C:SAS acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038988">
        <property type="entry name" value="Sas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029184">
        <property type="entry name" value="Sas4_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38422">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38422:SF1">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15460">
        <property type="entry name" value="SAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Something about silencing protein 4" evidence="2">
        <location>
            <begin position="261"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ92779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="553" mass="61233" checksum="01AF93EB85305619" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFN9</accession>
    <name>Q2HFN9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_00965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220186.1">
        <property type="nucleotide sequence ID" value="XM_001220185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFN9"/>
    <dbReference type="STRING" id="306901.Q2HFN9"/>
    <dbReference type="GeneID" id="4387281"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00965"/>
    <dbReference type="eggNOG" id="KOG2401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015244_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HFN9"/>
    <dbReference type="OMA" id="RQDAIKH"/>
    <dbReference type="OrthoDB" id="3247158at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.110:FF:000002">
        <property type="entry name" value="CCCH zinc finger and SMR domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045124">
        <property type="entry name" value="Su(sable)-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119:SF12">
        <property type="entry name" value="PROTEIN SUPPRESSOR OF SABLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="5">
        <location>
            <begin position="478"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="2">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="286"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="600"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ92730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="619" mass="66939" checksum="0AEFBA69A3D0FA94" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGM5</accession>
    <name>Q2HGM5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_00629</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219850.1">
        <property type="nucleotide sequence ID" value="XM_001219849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGM5"/>
    <dbReference type="FunCoup" id="Q2HGM5">
        <property type="interactions" value="1022"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HGM5"/>
    <dbReference type="GeneID" id="4387130"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00629"/>
    <dbReference type="eggNOG" id="KOG1691">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066963_3_0_1"/>
    <dbReference type="InParanoid" id="Q2HGM5"/>
    <dbReference type="OMA" id="DVFEACF"/>
    <dbReference type="OrthoDB" id="759142at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209457" description="GOLD domain-containing protein" evidence="9">
        <location>
            <begin position="25"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="40"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ92394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="220" mass="25097" checksum="83CE0F11E37E62B1" modified="2006-03-21" version="1">MARLRSVLQQVCSVLLLLAVGSNALKLDIQAGSGHDKTSRRCIRNFVAKDMLVVVTAIVDGWRGDGMQLNMHISDSTGNEYGKPKDIAGEQRTVFTSHADAPFDVCFENILTGSRYVEHPYRHIELDIDIGADAKDWSAIQATEKLKPVETELRRIEEMVAEVVNEMEYLRSREQTLRDTNESTNTRVKWFGFGTTFLLIGLWAWQIMYLRAYFRSKHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH64</accession>
    <name>Q2HH64_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 13">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2 13">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_00440</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="13">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2 13"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219661.1">
        <property type="nucleotide sequence ID" value="XM_001219660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH64"/>
    <dbReference type="FunCoup" id="Q2HH64">
        <property type="interactions" value="480"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HH64"/>
    <dbReference type="GeneID" id="4388272"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00440"/>
    <dbReference type="eggNOG" id="KOG0660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="Q2HH64"/>
    <dbReference type="OMA" id="SFFDFDY"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075018">
        <property type="term" value="P:positive regulation of appressorium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07849">
        <property type="entry name" value="STKc_ERK1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000073">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ92205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="353" mass="40914" checksum="93ECEECBA6A945B7" modified="2006-03-21" version="1">MSNAQNRGGARKISFNVSEQYDIQDVVGEGAYGVVCSAVHKPSGQKVAIKKITPFDHSMFCLRTLREMKLLRYFNHENIISILDIQKPRSYETFNEVYLIQELMETDMHRVIRTQELSDDHCQYFIYQTLRALKAMHSANVLHRDLKPSNLLLNANCDLKVCDFGLARSAASQEDNSGFMTEYVATRWYRAPEIMLTFKEYTKAIDVWSVGCILAEMLSGKPLFPGKDYHHQLTLILDVLGTPTMEDYYGIKSRRAREYIRSLPFKKKVPFRTLFDGTSDLALDLLEKLLAFNPVKRITVEEALKHPYLEPYHDPDDEPTAPPIPEEFFDFDKHKDNLSKEQLKQLIFQEIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHI0</accession>
    <name>Q2HHI0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_00324</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219545.1">
        <property type="nucleotide sequence ID" value="XM_001219544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHI0"/>
    <dbReference type="GeneID" id="4388211"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00324"/>
    <dbReference type="eggNOG" id="ENOG502SP40">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144932_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HHI0"/>
    <dbReference type="OMA" id="NSSMICG"/>
    <dbReference type="OrthoDB" id="3928926at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12798">
        <property type="entry name" value="Alt_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.350.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032382">
        <property type="entry name" value="AltA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16541">
        <property type="entry name" value="AltA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51895">
        <property type="entry name" value="AA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209255" description="AA1-like domain-containing protein" evidence="6">
        <location>
            <begin position="18"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="AA1-like" evidence="7">
        <location>
            <begin position="27"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ92089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="162" mass="17485" checksum="D9FAB418994BCDC2" modified="2006-03-21" version="1">MRFTFAATAILFGAALAAPAPQAEAPEIHETVSIKDFYARKSHLVNGTLDGPVDSVTFKIIASREEGTIGVTCTAIAAEGEDSIKFKPESYNCDGVKDTWDQYRFEVAEISEQNVYTIMVIHQTAPAFGFWGNADVPTYCRAGGNSSMICGQVAEVTADLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHJ3</accession>
    <name>Q2HHJ3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_00311</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219532.1">
        <property type="nucleotide sequence ID" value="XM_001219531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHJ3"/>
    <dbReference type="STRING" id="306901.Q2HHJ3"/>
    <dbReference type="GeneID" id="4387121"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00311"/>
    <dbReference type="eggNOG" id="ENOG502S9FG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013727_5_2_1"/>
    <dbReference type="InParanoid" id="Q2HHJ3"/>
    <dbReference type="OrthoDB" id="1421156at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718">
        <property type="entry name" value="OS01G0519700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718:SF3">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="425"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="480"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="518"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ92076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="610" mass="68046" checksum="7B9279EDE8C0C179" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHM1</accession>
    <name>Q2HHM1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219504.1">
        <property type="nucleotide sequence ID" value="XM_001219503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHM1"/>
    <dbReference type="STRING" id="306901.Q2HHM1"/>
    <dbReference type="GeneID" id="4387957"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00283"/>
    <dbReference type="eggNOG" id="KOG1401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_888527_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHM1"/>
    <dbReference type="OrthoDB" id="425114at2759"/>
    <dbReference type="UniPathway" id="UPA00078"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03109">
        <property type="entry name" value="DTBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684:SF3">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13500">
        <property type="entry name" value="AAA_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ92048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="313" mass="34587" checksum="39FDDFBF788C5DD8" modified="2006-03-21" version="1">MTLIPPARSAAVALPANSPGLRGQHRGRQDSGDHYSLQKVLTGSAADEETSYLKPVSTGAALRRRRLVRTLFQYELAVSPHIAAQASGQPIVADKMVLAEISKSAARQVSRGPGWLFVETAGGVHSPAPSGSTQADLYRPLRLPVVLVGDSKLGGISQTISAFESLKLRGYDVEMVLLFREGQFQNHQYLAEYFKDQHNIPVMTFPEPPNRIRGDTTADAAAMSRYYEHNSGNDSNLHDILKHLDTRHNNRISRLESMSTKASLNNLVPLHPTEGPHCRLNHHHATPFTVTWSKTRTRSSISNILWRVHDGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI66</accession>
    <name>Q2HI66_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_00088</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219309.1">
        <property type="nucleotide sequence ID" value="XM_001219308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HI66"/>
    <dbReference type="STRING" id="306901.Q2HI66"/>
    <dbReference type="GeneID" id="4387582"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00088"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_31_8_1"/>
    <dbReference type="InParanoid" id="Q2HI66"/>
    <dbReference type="OMA" id="INGTHET"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1066"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ91853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1148" mass="125219" checksum="89A8AD350BB838BB" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GLY1</accession>
    <name>Q2GLY1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_11075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408038">
        <property type="protein sequence ID" value="EAQ82899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230251.1">
        <property type="nucleotide sequence ID" value="XM_001230250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GLY1"/>
    <dbReference type="GeneID" id="4397376"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_11075"/>
    <dbReference type="HOGENOM" id="CLU_1749424_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GLY1"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ82899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="149" mass="15816" checksum="4C6B52B50807EC4C" modified="2006-03-21" version="1">MPCHNNMPCHGNMLCHGNMLCHPPHQNVAGRLAGLTVTRAASSSNSSIPDSSHWERLRRTDGFVGLGFVPDAGTGGVEVCRTAGAVKAVPQVPWSLVPQRGRSLWSAPWLSQSLEGGRGPGDFTAGASGRKWQAVSDFAGRKVGLLFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMV2</accession>
    <name>Q2GMV2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228629.1">
        <property type="nucleotide sequence ID" value="XM_001228628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMV2"/>
    <dbReference type="GeneID" id="4396340"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10702"/>
    <dbReference type="HOGENOM" id="CLU_2120818_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GMV2"/>
    <dbReference type="OrthoDB" id="4570014at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="114" mass="13226" checksum="275F1E383A2AF292" modified="2006-03-21" version="1">MTDQKSQGKQFSNVLVNLKGVHSKWHGDAAQLHEPPARSDFIEPKNVLDKDMRDSILKLERRGEETRRRFEQDHRHESWFQEWAAMPESGQGTETDDVEDAALWRDPGVSEPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMW6</accession>
    <name>Q2GMW6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL28m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_10688</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228615.1">
        <property type="nucleotide sequence ID" value="XM_001228614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMW6"/>
    <dbReference type="FunCoup" id="Q2GMW6">
        <property type="interactions" value="181"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GMW6"/>
    <dbReference type="GeneID" id="4396374"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10688"/>
    <dbReference type="eggNOG" id="KOG3278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064548_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GMW6"/>
    <dbReference type="OMA" id="MLRWRIM"/>
    <dbReference type="OrthoDB" id="361870at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.40:FF:000003">
        <property type="entry name" value="54S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="entry name" value="Ribosomal protein L28/L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_bL28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribosomal_bL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="Ribosomal_bL28/bL31-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribosomal_bL28_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="L28p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ84284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="254" mass="28633" checksum="9F7239621FDEBB1C" modified="2006-03-21" version="1">MPSTHPSIQTCLRAASRPATTSFPRFSTRTFTTTPPTLYKQPRVPGSDIPIPSVTAPQHHIPPYPYGPRQVYHQSNTGLYGSARIRFGNNVSERNNIKTRRQWRPNVHHKRLWSASLGVFVRTRVTARVLRTVDKAGGLDEYLLGRTPQRVRDLGPWGWKLRWRIMQTPAVRARFAAEREALGLPPKEDDELILEAAQALPDGTAAGEALMAKTDKMLAEETEFELYTETEAAAAAETAEEMKDGFMKEEKPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNB5</accession>
    <name>Q2GNB5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_10539</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228466.1">
        <property type="nucleotide sequence ID" value="XM_001228465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNB5"/>
    <dbReference type="FunCoup" id="Q2GNB5">
        <property type="interactions" value="1042"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GNB5"/>
    <dbReference type="GeneID" id="4396394"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10539"/>
    <dbReference type="eggNOG" id="KOG1376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015718_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GNB5"/>
    <dbReference type="OMA" id="YMASCIL"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000008">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="49"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="250"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ84135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="451" mass="50161" checksum="821B4617AC34EB5F" modified="2006-03-21" version="1">MREIISLNVGQAGCQIANSCWELYCLEHGIQPDGYLTEERKAADPDQGFSTFFSETAAGNGKYVPRTIYCDLEPNVVDEVRTGAYRGLFHPEHMITGKEDASNNYARGHYTVGKELIDQVLDKVRRVADNCSGLQGFLVFHSFGGGTGSGFGALLMERLSVDYGKKSKLEFCVYPAPQTATSVVEPYNSILTTHTTLEHADCSFMVDNEAIYDICRRNLGLERPNFENLNRLIAQVVSSITASLRFDGSLNVDLNEFQTNLVPYPRIHFPLVAYAPVVSAAKAAHEANSVQEMTMSCFEPNNQMVKCDPRHGKYMATCLLYRGDVVPKDAHSAVATLKTKRTIQFVDWCPTGFKLGICYQPPHQVPNGDLAKANRAVCMLSNTTAIAEAWSALSSKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALERDYEEVATDSMGEEELEAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNE2</accession>
    <name>Q2GNE2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_10512</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228439.1">
        <property type="nucleotide sequence ID" value="XM_001228438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNE2"/>
    <dbReference type="GeneID" id="4396856"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10512"/>
    <dbReference type="HOGENOM" id="CLU_1686361_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNE2"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208296" evidence="3">
        <location>
            <begin position="43"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ84108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="156" mass="16433" checksum="EF95CF0488C535F5" modified="2006-03-21" version="1">MRRFNPWAFTSRTIPGSFSPRTSLLIIPLSFLCLLLVHIILGGEDGGEEELEEVGEGGERGGGGGGFVGGGEGVAVAGVVVVVGFVARRFEEVGCEEGCERGEEWKENREDGEGGRDGQGEGRDGDVFVAGTVLVSGWETGGWDAYIATPTRARIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNY5</accession>
    <name>Q2GNY5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF726 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_10319</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228246.1">
        <property type="nucleotide sequence ID" value="XM_001228245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNY5"/>
    <dbReference type="ESTHER" id="chagb-q2gny5">
        <property type="family name" value="Duf_726"/>
    </dbReference>
    <dbReference type="GeneID" id="4396595"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10319"/>
    <dbReference type="eggNOG" id="KOG2385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007407_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GNY5"/>
    <dbReference type="OMA" id="KDIHWED"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF22">
        <property type="entry name" value="DUF726 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G12860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ83915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="689" mass="74943" checksum="749B767479418327" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GP68</accession>
    <name>Q2GP68_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228163.1">
        <property type="nucleotide sequence ID" value="XM_001228162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GP68"/>
    <dbReference type="GeneID" id="4396828"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10236"/>
    <dbReference type="eggNOG" id="ENOG502RNX1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1234863_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GP68"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="224" mass="23774" checksum="52D77DF47C573CFF" modified="2006-03-21" version="1">MMGSLLLRMLLKIEAKRYERLLKAHGINLAAPRRAAAAAAAAGASTAGEDSGADPQTPASKKRKRVGVAKKEEDEEETPTKKERGVKKERGVKKEESDDDVKVKDEYGSFTTNTITIITTGSNHSAATATYFRVGGVSKSDEPETSPRQQDPAGHRSGRASGGAAEGDNNDDCLVVGDDSVASPSLGPKQAPVAHSRGHLSMNWREDTYLCLGELDGGPFTLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GP86</accession>
    <name>Q2GP86_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228145.1">
        <property type="nucleotide sequence ID" value="XM_001228144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GP86"/>
    <dbReference type="GeneID" id="4396534"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10218"/>
    <dbReference type="HOGENOM" id="CLU_2941528_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GP86"/>
    <dbReference type="OrthoDB" id="4683770at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208443" evidence="1">
        <location>
            <begin position="20"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="60" mass="6329" checksum="1A8C163909581502" modified="2006-03-21" version="1">MQFSATVLLLLGNAVLGLAMPAPASNAAEGLEKRCIATGDDCTNRYTECCSSIDSETTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPP5</accession>
    <name>Q2GPP5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7708 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227986.1">
        <property type="nucleotide sequence ID" value="XM_001227985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPP5"/>
    <dbReference type="STRING" id="306901.Q2GPP5"/>
    <dbReference type="GeneID" id="4396040"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10059"/>
    <dbReference type="eggNOG" id="ENOG502SH5A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035524_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPP5"/>
    <dbReference type="OMA" id="YAHIIQF"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7708" evidence="2">
        <location>
            <begin position="26"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="447" mass="49072" checksum="5A61851106825EE0" modified="2006-03-21" version="1">MARETVHKDHPLQRHPRRARPAPPRSVVNHEALASCVAKSLTRIADTLASVEITAVLYPTEQMKLALAEIYAHMIRFFLRAQDWLTESSWMRALHSVTHPKELRYDDILQDITAATTHFQRLAVAASQAEQRDIHPRLKQQLTAAAGHQQINASAMYNTNTALTDLQFSSILNSLSNPPLDDPDKVLQQATFLRSRAALHRKATHDAFWLHPRFQTWSESSSSNLVMVQGTFSGRSAMRACLIDAIDAIRQANATALWALKTSDPAAVAPHSGASISSVELLKYLTAQALRLGGPPSTTTERTLALSCARFQTARGEREWIGLLAGSLASMGSKHVFIVVDVELLGREAAAGIAQCNETRGSSSDRFTLPESLKELFAQVKARAPGIVVKVLLVSYGSPLFRAISDVYREDVLLAGRPRPQRSRAAGRAAHGGLGIRRGQLRRKLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQ89</accession>
    <name>Q2GQ89_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha 1,4-glycosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227792.1">
        <property type="nucleotide sequence ID" value="XM_001227791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQ89"/>
    <dbReference type="GeneID" id="4396066"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09865"/>
    <dbReference type="eggNOG" id="ENOG502RJ0F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2222971_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQ89"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11899" checksum="996FCE9C9C1E5991" modified="2006-03-21" version="1">MGTYMHTRFAATDPSLADLFTSLRDPILRADFLRYLILLRDGGVWADINVYPHRPVAEWVPERFRGRLAQYTVLAKPGHPAVGVLVEEVTGNLRRLVGEKGRVVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQM9</accession>
    <name>Q2GQM9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Oxysterol-binding protein-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_09725</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227652.1">
        <property type="nucleotide sequence ID" value="XM_001227651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQM9"/>
    <dbReference type="GeneID" id="4396278"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09725"/>
    <dbReference type="eggNOG" id="KOG2210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029722_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQM9"/>
    <dbReference type="OMA" id="WNYLDAP"/>
    <dbReference type="OrthoDB" id="48057at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF212">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="362"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ83321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="48334" checksum="317F2F3705639028" modified="2006-03-21" version="1">MWSFSANNPPEAATPSPDVPATDEPQNDGSKLKTFISILRKFIGVADLASVRFSLPSQLLEPTPNLEYWNYLDSPNAFIAIGTADEPVDRMLEVLRFWFTKDLKYAKGKPCKPYNSCLGEFFRCNWETEDDAPKIDTSALRRNSSSPGSSASSMKSAKLSVPAGLGSGDARAASTVSVSQSAKNPAKPVRVSYLTEQTSHHPPVSAFYVSCPEKGIHAKGFDQITAKFTGTSIKVMPGEHNLGIFITVERRDHETYQLTHPAAHLGGILRGALSVSVGDMAYVTCPETKLKAILRYYDDGWLGRDNEQSRGHHLPNSHPPENQITIIDIAPLAVAPKVLPPSEKQLPNESLQLWGEVTKAILAKQFSRATTVKQELEEAQREKARERERTKETWKPVFFEQATDKAGKPSLTDKGREVLNRAQKGDWSMDGIISQEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQQ4</accession>
    <name>Q2GQQ4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_09700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227627.1">
        <property type="nucleotide sequence ID" value="XM_001227626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQQ4"/>
    <dbReference type="GeneID" id="4396243"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09700"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_6_1"/>
    <dbReference type="InParanoid" id="Q2GQQ4"/>
    <dbReference type="OMA" id="WSRYDQK"/>
    <dbReference type="OrthoDB" id="3365399at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF12">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="550"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="146"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="622"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="583"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="622"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="640"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ83296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="657" mass="71103" checksum="45DBEAD8EEC04FC5" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GR16</accession>
    <name>Q2GR16_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_09588</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin-dependent halogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GR16"/>
    <dbReference type="GeneID" id="4396355"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09588"/>
    <dbReference type="eggNOG" id="ENOG502QW6Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024648_4_2_1"/>
    <dbReference type="InParanoid" id="Q2GR16"/>
    <dbReference type="OMA" id="PENSAWN"/>
    <dbReference type="OrthoDB" id="3340390at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050816">
        <property type="entry name" value="Flavin-dep_Halogenase_NPB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="7"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ83184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="546" mass="59914" checksum="7658946097D3189A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GR74</accession>
    <name>Q2GR74_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_09530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227457.1">
        <property type="nucleotide sequence ID" value="XM_001227456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GR74"/>
    <dbReference type="STRING" id="306901.Q2GR74"/>
    <dbReference type="GeneID" id="4395447"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09530"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2037798_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GR74"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF4">
        <property type="entry name" value="CYTOCHROME P450 98A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ85516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="121" mass="13670" checksum="B944CFAB870839A8" modified="2006-03-21" version="1">MLSEKLLDSFALVKLQAAIPDASLLNVGLGLNPTVWINDAWCAHEIFEKKAQIYASRPRMVVFGELGTGQSNLVTMRIRNQEERDHWRIHRKLMHIGVGVQSVRGYRAIQNNETLGALCDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRQ1</accession>
    <name>Q2GRQ1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_09353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227280.1">
        <property type="nucleotide sequence ID" value="XM_001227279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRQ1"/>
    <dbReference type="STRING" id="306901.Q2GRQ1"/>
    <dbReference type="GeneID" id="4395127"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09353"/>
    <dbReference type="eggNOG" id="ENOG502SX1Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071678_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRQ1"/>
    <dbReference type="OMA" id="ENTLAMP"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ85339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="295" mass="33187" checksum="FD35440A4EE0B9B8" modified="2006-03-21" version="1">MASSSAFNNYIVDSAMGPTCSRQVPPGSFGVPARSGHANRKGAWLSWKSAGLIPLAIAAPASRFIGDDEPRRASRMLLQVLADDEHDKSHDYRYSWGYTIFRTVYTPGSDEAFPQAIERLAIYAKAYVNDDIALKRRPNQEPRDPLPNRELWGRYYNQVIEDEDTLAHATVEDVGRRFDVWISEHLNLDALPRRKTSNARFCYCLMLDQESVDNILTSPEEPFGFSRSDSRHQPGWVKVVTAEQQPGRRQGCGLRVGIRTMLWALWFGSQDPDFILEEQPGVDGGDGGHDVHGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GS15</accession>
    <name>Q2GS15_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tryptophan synthase beta chain-like PALP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_09239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227166.1">
        <property type="nucleotide sequence ID" value="XM_001227165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GS15"/>
    <dbReference type="STRING" id="306901.Q2GS15"/>
    <dbReference type="GeneID" id="4395723"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09239"/>
    <dbReference type="HOGENOM" id="CLU_1786628_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GS15"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42937">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42937:SF1">
        <property type="entry name" value="DIAMINOPROPIONATE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ85225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="15498" checksum="5572C9B0A202DEED" modified="2006-03-21" version="1">MTDLTVISGKWHVPTQTSCPCDAIAEAFSAAASTQGGLLVQDNSFEEYEQIPVWILEGYSTLLTEVNQQLSEKGLDTATLMVSPALGPCGAATLAALWKLRDAEDIQPRCFLSEEAVVVLLGTEGQREYQVPIPISNVGAVTAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSG4</accession>
    <name>Q2GSG4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_09090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227017.1">
        <property type="nucleotide sequence ID" value="XM_001227016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSG4"/>
    <dbReference type="GeneID" id="4395574"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09090"/>
    <dbReference type="HOGENOM" id="CLU_986959_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSG4"/>
    <dbReference type="OrthoDB" id="10281054at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ85076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="282" mass="30468" checksum="30F4CFDB1D1A8F84" modified="2006-03-21" version="1">MSRSALLSHLLTKDFPSRSNATLLRLSNISPISAPPKHDQFEEIATWREQVTLASESRTGSNVGQTITYAGALKAFMWLSGPMVMSRPCQDRVRCPSATPHCPSMRLVAPQCPKQPVAANLSCDVGTLEAAVLAGYCLTPSLAKSPSTTHSRQLAPPLGTANAGQSSTCGPSRYCRPFRTSSTTALPVILSSIGGPVYRLPPAKQYYRTLAESGVPVCTSRWAGNGTPTEALDTALYPVPRTVDPWQRLLEYRGRNRALTPGDSSAASDRHLCSMDVRRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSU6</accession>
    <name>Q2GSU6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226885.1">
        <property type="nucleotide sequence ID" value="XM_001226884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSU6"/>
    <dbReference type="GeneID" id="4395887"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08958"/>
    <dbReference type="eggNOG" id="ENOG502R895">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1686358_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSU6"/>
    <dbReference type="OrthoDB" id="4585340at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="156" mass="18324" checksum="FCC39CFCA1EF1608" modified="2006-03-21" version="1">MAGLCNCPRCFRTGWEAEETRNLSIIREGLWKLFSILSGWTLVTQKSLELELKAHHSPSNSDRWFKMNPRKETPPRKQGRLHPLSSIGLRFPTELPRVDVVTRLTLGRQLQHRLQPLQLRSLLHKLGHLEYMVYEPERDWNRFYAGALMTTYDITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GT57</accession>
    <name>Q2GT57_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_08847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226774.1">
        <property type="nucleotide sequence ID" value="XM_001226773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GT57"/>
    <dbReference type="GeneID" id="4395786"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08847"/>
    <dbReference type="eggNOG" id="ENOG502SWJ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169171_1_2_1"/>
    <dbReference type="InParanoid" id="Q2GT57"/>
    <dbReference type="OrthoDB" id="5586401at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039870">
        <property type="entry name" value="Coa4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13639">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13639:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="42" mass="5097" checksum="EF34F2C9347315B4" modified="2006-03-21" version="1">MTDCYYETKDWRACKNEMERFRECWKAQGNDKRTSTKDANDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTL8</accession>
    <name>Q2GTL8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_08686</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226613.1">
        <property type="nucleotide sequence ID" value="XM_001226612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTL8"/>
    <dbReference type="GeneID" id="4394981"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08686"/>
    <dbReference type="eggNOG" id="ENOG502QU4U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GTL8"/>
    <dbReference type="OMA" id="CPFRPLV"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="318"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ84672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="427" mass="46670" checksum="EA9E5142630C0AE7" modified="2006-03-21" version="1">MLAVGECSREPCGIPPGSLQYGATPAGNAFMLAAFAALIPPVIYAGFRYRTLAHTSLLLTALVFEVVGHVGKIFLAANPNSHAYSTLYLLGTHWGAILIGSAANLVLPHAMVIYGEEFRLVSDPVYLNMLFFILDIFALAFQSVGIGFASTAHTSAEVSQGVSILLTGLAIQALNLLAFLGTYRYFRYKLSHRRYILDDRYSHVYLSRWFTYFMICIQVVAALLLLRTAVRIAIFADGLDSAFATSQVTTFLLDDTIVLVAVLIIAICPPGRAFGGAWASTSPMAASPDRPHTLPLRLRRHRRNRSSRINKRVISLPYTSPSASPRFSPGYTPRGGMTPGLPAHPSPRAPPLISPLMSPRNNPVHQRAPYELSPTQEVPYMAPQESPGMDSTMWMASPPIDHGRKRRMRAGSGPETNQMVDGDALWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUP9</accession>
    <name>Q2GUP9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_08305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ87052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225961.1">
        <property type="nucleotide sequence ID" value="XM_001225960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUP9"/>
    <dbReference type="GeneID" id="4394468"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08305"/>
    <dbReference type="eggNOG" id="ENOG502S4C9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110806_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUP9"/>
    <dbReference type="OMA" id="CMDIYIR"/>
    <dbReference type="OrthoDB" id="5563033at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009598">
        <property type="entry name" value="BCALP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13259">
        <property type="entry name" value="BLADDER CANCER 10 KD PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13259:SF1">
        <property type="entry name" value="BLADDER CANCER-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06726">
        <property type="entry name" value="BC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01396">
        <property type="entry name" value="BC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ87052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="158" mass="18047" checksum="98092787FDFAC592" modified="2006-03-21" version="1">MFCLRSWLPLLFIPTNASPSFIFLFFLCTYFLNRPCFYCSFLLLILFLTSCNWSDRCFLDLSSNWFQPRPAGSYIYLPVSWWKAEAATGPAAGEDVNATVSAVVAEMFNTTAGALATAATEQIARTRVEWTGLGLEWLRSLVGRREWRIDCLDLYIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUU7</accession>
    <name>Q2GUU7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine racemase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_08257</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ87004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225913.1">
        <property type="nucleotide sequence ID" value="XM_001225912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUU7"/>
    <dbReference type="STRING" id="306901.Q2GUU7"/>
    <dbReference type="GeneID" id="4393690"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08257"/>
    <dbReference type="eggNOG" id="KOG3157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1481811_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUU7"/>
    <dbReference type="OrthoDB" id="10264196at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase N-terminal" evidence="3">
        <location>
            <begin position="61"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ87004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="182" mass="19711" checksum="14E8CBAF8F839009" modified="2006-03-21" version="1">MSETKMNVDPARASALISQLKGVSERVAAVAKGRPRLKGVEPKSRVATQDYPMAFYRWSPVSIDNLKKAQLLDKYRGEKIKAEPETQKLNIHVQVNTSGEESKSGCAPGEELVSLCRSIVNDCPSLHLLGLMTIGAIARSVATTAENENEDFKVAGEAEGFGCQRTGLEQGTGVEHGHERGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV05</accession>
    <name>Q2GV05_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225855.1">
        <property type="nucleotide sequence ID" value="XM_001225854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV05"/>
    <dbReference type="GeneID" id="4393399"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08199"/>
    <dbReference type="HOGENOM" id="CLU_1377975_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GV05"/>
    <dbReference type="OrthoDB" id="4589102at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="198" mass="20688" checksum="EB3187DB98633FC3" modified="2006-03-21" version="1">MSSRTTANGQLPSGVSANSSTGRPQTAQGAQPQSTARQPTLMQTGTSGRPAPDPTTSSSTSASQGPSNADNRSTASAAATEARPPSRPSTASTASTMVRHSSFMPKERAAKLSGEGENRARQAAIFQDALNKYKGSIDAEAKAKAAYAAHGKRVENDPCMMGRDWHSAGLEAAELANTWEKAANSARFLHEALRRATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV24</accession>
    <name>Q2GV24_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225836.1">
        <property type="nucleotide sequence ID" value="XM_001225835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV24"/>
    <dbReference type="GeneID" id="4393405"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08180"/>
    <dbReference type="HOGENOM" id="CLU_3087063_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GV24"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208499" evidence="1">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="52" mass="5461" checksum="3FF34CC3B955AA63" modified="2006-03-21" version="1">MPPPSAALWNMLVGRWVVLGGGAVWEQQAVAGAGCGKSVVPAHHEKPREGRD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-03" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVK6</accession>
    <name>KAD2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenylate kinase</fullName>
            <ecNumber evidence="1">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Adenylate kinase cytosolic and mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ADK1</name>
        <name type="ORF">CHGG_07998</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <text evidence="1">Predominantly mitochondrial.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and disassembling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylate kinase family. AK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="1"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225654.1">
        <property type="nucleotide sequence ID" value="XM_001225653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVK6"/>
    <dbReference type="SMR" id="Q2GVK6"/>
    <dbReference type="FunCoup" id="Q2GVK6">
        <property type="interactions" value="748"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GVK6"/>
    <dbReference type="GeneID" id="4393286"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07998"/>
    <dbReference type="eggNOG" id="KOG3078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032354_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GVK6"/>
    <dbReference type="OMA" id="VYHEQTA"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03168">
        <property type="entry name" value="Adenylate_kinase_AK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028587">
        <property type="entry name" value="AK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001380">
        <property type="entry name" value="PRK00279.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011100">
        <property type="entry name" value="PRK14527.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000365669" description="Adenylate kinase">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMP" evidence="1">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="1">
        <location>
            <begin position="167"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="50"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="97"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="177"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03168"/>
        </source>
    </evidence>
    <sequence length="275" mass="30143" checksum="E3CB726020839D0E" modified="2006-03-21" version="1">MGYLDDEVKRLQGIISNIEGRVQALESRQLGGNQKKTAEEIRMILIGPPGAGKGTQAPKIKEKFNCCHLATGDMLRSQVAKKTTLGREAKKIMDAGGLVSDDIVIGMIKEELDNNKECKGGFILDGFPRTVPQAEGLDKMLRERSQSLQHAVELKIDDQLLVSRITGRLVHPASGRSYHTTFNPPKVHMTDDITGEPLIQRSDDNAEALKKRLATYHKQTAPVVDYYRKTGIWQAIDAAQAPGQVWKSLQAIFDGDKAKAKKAGSGLLSKLTPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVR7</accession>
    <name>Q2GVR7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_07937</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225593.1">
        <property type="nucleotide sequence ID" value="XM_001225592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVR7"/>
    <dbReference type="STRING" id="306901.Q2GVR7"/>
    <dbReference type="GeneID" id="4394187"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07937"/>
    <dbReference type="eggNOG" id="KOG1940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013368_4_2_1"/>
    <dbReference type="InParanoid" id="Q2GVR7"/>
    <dbReference type="OMA" id="METQFRN"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16464">
        <property type="entry name" value="RING-H2_Pirh2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039512">
        <property type="entry name" value="RCHY1_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017921">
        <property type="entry name" value="Znf_CTCHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037275">
        <property type="entry name" value="Znf_CTCHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319:SF0">
        <property type="entry name" value="AND RING FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319">
        <property type="entry name" value="RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14599">
        <property type="entry name" value="zinc_ribbon_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161245">
        <property type="entry name" value="Zinc hairpin stack"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51270">
        <property type="entry name" value="ZF_CTCHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="7">
        <location>
            <begin position="235"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="CTCHY-type" evidence="8">
        <location>
            <begin position="304"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="370"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="564"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="518"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="595"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="661"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ86684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="703" mass="77917" checksum="4E77E3CA8D58B0FE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GW10</accession>
    <name>Q2GW10_CHAGB</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GW10"/>
    <dbReference type="GeneID" id="4393159"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07844"/>
    <dbReference type="eggNOG" id="ENOG502S29P">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1234860_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GW10"/>
    <dbReference type="OrthoDB" id="5329385at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031342">
        <property type="entry name" value="Mug163-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17119">
        <property type="entry name" value="MMU163"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="20"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="224" mass="24453" checksum="262F7D28D7916FCD" modified="2006-03-21" version="1">MSTPARILRCPLHGSAARVSPAATCPAPSPWGAPSAIERRHSSEAPAFFLSTTSRPPRASPLPSTPKKNLATLQNPASPPKLIPDAALFTYHPPLLSPEPGNNKPPDERKVKLGKTLRILQSHLPTLLQSPPPQGILSPRITLHLFPSTHPHLPTVSGRVAYTAALWSSPIAWNRLPLVGNVRLHILSERMIESSAYDSRDRPAGGRRLKWSLWRCTDYGALDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWA3</accession>
    <name>Q2GWA3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CHGG_07751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWA3"/>
    <dbReference type="GeneID" id="4393715"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07751"/>
    <dbReference type="HOGENOM" id="CLU_2133226_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWA3"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="113" mass="12228" checksum="9959ECC5728720D8" modified="2006-03-21" version="1">MGPGISNDLSLPPFVELDRGSPKPDPTAMYPARLMSADVRYQTRMTANLHAGMSFGHTTSLLASPSGNFGAGTPATVTPPRCGIQRQPQVISNTMQWYSDACMQSKSLWLRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWZ9</accession>
    <name>Q2GWZ9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225161.1">
        <property type="nucleotide sequence ID" value="XM_001225160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWZ9"/>
    <dbReference type="GeneID" id="4394395"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07505"/>
    <dbReference type="eggNOG" id="ENOG502S87B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080238_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWZ9"/>
    <dbReference type="OMA" id="WCERVEM"/>
    <dbReference type="OrthoDB" id="5599753at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="292" mass="32482" checksum="82BA3EAABC1AFCBE" modified="2006-03-21" version="1">MFSKFVNFPSPRLAVCLAVLPVALPVTYLIYLDHAVSKQLNTATGVRNTKRRTSTVPANVTRPITLPEEVRADESEWILAYERITSKALAPSSLPDNLSAVVTDYVRATMTAFSWTPQAFLLRAAAGDKAVKKTFDTPYIQNLGFCNGERVNGFWSVVYRGNGDLQEHERVEMALDAPPTYKGARVSGVIVAGVEVQGDGGVVFVNETWMWRKEDEAPLLLESRFGGWFHVVVSGWLVMKGEEACSARQVRRGALRRSVNPAVRHQQGSQTPTTQRVQRRKPSNYITTDQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXQ3</accession>
    <name>Q2GXQ3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_07251</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224907.1">
        <property type="nucleotide sequence ID" value="XM_001224906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXQ3"/>
    <dbReference type="STRING" id="306901.Q2GXQ3"/>
    <dbReference type="GeneID" id="4394175"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07251"/>
    <dbReference type="eggNOG" id="ENOG502QUM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016972_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GXQ3"/>
    <dbReference type="OMA" id="TEAYWEF"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF42">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02280)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="60"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ85998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="373" mass="40099" checksum="BE1BA366A457DB82" modified="2006-03-21" version="1">MGRSDFAVSTYDAGGSSDSGSAWNPKNWTRRIWLIIATVIVLIVVVIVGAVVGVRATRDNNGGNNSYPDYFKLNYTLIDTYSGTSFFDKFNYFNTYDPAGGFVHYVDPSYAGQYNLTYATPSTALIRVDTTVGPGSEPDASTGRFSVRLESKAQYGPGLFLFDVKHTPYGCGTWPALWLTDPANWPTNGEIDIMEAVNGATSGNLVALHTTDDCSMGDIQRQMAGTAGQGDCHNATNSNTGCTVTGPGATYGPEFNKAGGGVVALEWRNEGIRVWVFGREGSGGVRSLPVGTSPDPSAWGRPLADFPATNCDMGRHFRNQSIVVNIDLCGYLTEAVWESSGCPSTCTDYVANNPLAFGNAFWEFGAFQVFEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXS9</accession>
    <name>Q2GXS9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_07225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224881.1">
        <property type="nucleotide sequence ID" value="XM_001224880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXS9"/>
    <dbReference type="STRING" id="306901.Q2GXS9"/>
    <dbReference type="GeneID" id="4393225"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07225"/>
    <dbReference type="eggNOG" id="KOG4373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4392">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_376827_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GXS9"/>
    <dbReference type="OrthoDB" id="1920326at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000100">
        <property type="entry name" value="3'-5' exonuclease/helicase (Wrn), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="7">
        <location>
            <begin position="443"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="691"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="702"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ85972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="736" mass="80325" checksum="7ED3BEC55653E480" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GY57</accession>
    <name>Q2GY57_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tetratricopeptide SHNi-TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_07097</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224753.1">
        <property type="nucleotide sequence ID" value="XM_001224752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GY57"/>
    <dbReference type="STRING" id="306901.Q2GY57"/>
    <dbReference type="GeneID" id="4393234"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07097"/>
    <dbReference type="eggNOG" id="KOG4563">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028900_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GY57"/>
    <dbReference type="OMA" id="IAECHYK"/>
    <dbReference type="OrthoDB" id="5587616at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051730">
        <property type="entry name" value="NASP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019544">
        <property type="entry name" value="Tetratricopeptide_SHNi-TPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081:SF1">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10516">
        <property type="entry name" value="SHNi-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide SHNi-TPR" evidence="5">
        <location>
            <begin position="240"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="88"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="389"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="321"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="105"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="423"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ85844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="436" mass="47103" checksum="02C17ED02291FFD9" modified="2006-03-21" version="1">MATPTPGTGTSTPMQLDPEEAAKSLRVSLADLSAKAAALYSQKQYEDASEVYAQAAEMQAEMNGEMNPENAEILFLYGRALFKVGQSNSDVLGGKAPETKKQPKPAKAATSKNGSAAATASKTSGAVEAVDDAAAQGAANQENEEPKPEQKKALFQFQGDENFTDSEEEEAEEGEGEEEEEEEDDLAVAFEILDLARLLFNKRLEDLQAEDEAHQGKGKEVAEPGNDSAAVKHIKERLGDTHDLLAEISLENERYPNAITDSRASLKYKEELYPFESEIIAEAHFKLSLALEFASATKASDDTTGGGEGEHIDQGLRDEAASALEAAINSTKLKLQNKEVELTTLHNPDDNEATRRQIADVKEILADMEQRLVDLRKPPVDINAALGIPAAPTPEVSEEVKQKAKDLSGLVRKKRKAEEPEEGGAKKVREGDAGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYC5</accession>
    <name>Q2GYC5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_07029</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224685.1">
        <property type="nucleotide sequence ID" value="XM_001224684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYC5"/>
    <dbReference type="STRING" id="306901.Q2GYC5"/>
    <dbReference type="GeneID" id="4393850"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07029"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_3_1"/>
    <dbReference type="InParanoid" id="Q2GYC5"/>
    <dbReference type="OMA" id="GWIHIRK"/>
    <dbReference type="OrthoDB" id="4160219at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF6">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="497"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ85776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="54460" checksum="36BE64953C333EE1" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYK4</accession>
    <name>Q2GYK4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proteasome alpha-type subunits domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_06950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224606.1">
        <property type="nucleotide sequence ID" value="XM_001224605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYK4"/>
    <dbReference type="FunCoup" id="Q2GYK4">
        <property type="interactions" value="968"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GYK4"/>
    <dbReference type="MEROPS" id="T01.971"/>
    <dbReference type="GeneID" id="4394457"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06950"/>
    <dbReference type="eggNOG" id="KOG0182">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_4_1_1"/>
    <dbReference type="InParanoid" id="Q2GYK4"/>
    <dbReference type="OMA" id="YGYDMPV"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Proteasome subunit alpha type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ85697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="254" mass="27940" checksum="099F4ADF05A333F2" modified="2006-03-21" version="1">MAGNAGYDRHITIFSEQGRLFQVEYAFKAITAANIMSIGVRGKDCAVVLSQKKVPDKLIDPSSVSHIFQISPSVGCVMTGSIADARAFSQRAQSEAADFKYKFGYEMPCDALAKRLANISQVYTQRAYMRPYGVATTLISLDSEVGPQLFKCDPAGYYIGYKGTSAGPKQQEALNHLEKKLKNKDHAPGDWKEVVELAITTLSTVLSMDFKKTEIEIGIVGGPRADGKEGTTPDFRRLTEEEIEERLQAIAEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYW8</accession>
    <name>Q2GYW8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224492.1">
        <property type="nucleotide sequence ID" value="XM_001224491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYW8"/>
    <dbReference type="STRING" id="306901.Q2GYW8"/>
    <dbReference type="GeneID" id="4394104"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06836"/>
    <dbReference type="eggNOG" id="ENOG502SF1H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_568574_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYW8"/>
    <dbReference type="OMA" id="EMAHDST"/>
    <dbReference type="OrthoDB" id="5368821at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="480" mass="52249" checksum="129EE2E84630B7AD" modified="2006-03-21" version="1">MDEEDMPPLPEDLSTLPILHSGQAVAGMVVTWKQWLLSRATNWQPQISSLAGVIVSVLDDNALEVRLAKRDRSLDHNEKVYDDDGNRVYDKFELPGMDDEHDVAAEQGYRTLDFADMIEPRILSPTPEVARTTSPVNQLSNAEQNPVPRDAIRAAELKSPDDRVSVTPEVVQVERNGVNAAQAGISAPYDGGQSMVSETSVLPAPIVTSIPEDRRHEISLMIGDAGFRKDVDPTVTHITDNAGLDLNSPSQQLEEMAHDSTFLASEISRAQGRTSPQLPSQLTSNNSDSQPIRLQPFYGFSDPTQEPPDERQVAYPTLNIPPSETGSLHSGRQVDPDFSIDLGHDSLHDLDGPATMSRSTIGRTDDEQNILRGEAEHDGGSTSEADLSDSSIPSLSDMWTSASTIGSKISNKHAGKFTLKPNVAPNSGPEPEVEEDYAEDSIDETYEEISMPTGSGWVRKPRARRGLGVGWSPGLNLTDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYY8</accession>
    <name>Q2GYY8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_05258</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224472.1">
        <property type="nucleotide sequence ID" value="XM_001224471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYY8"/>
    <dbReference type="GeneID" id="4392103"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05258"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_289494_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYY8"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ88639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1059" mass="115279" checksum="3ED1C90831AE6F5B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZ18</accession>
    <name>Q2GZ18_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_05228</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224442.1">
        <property type="nucleotide sequence ID" value="XM_001224441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZ18"/>
    <dbReference type="STRING" id="306901.Q2GZ18"/>
    <dbReference type="GeneID" id="4393103"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05228"/>
    <dbReference type="eggNOG" id="KOG3216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_41_2_1"/>
    <dbReference type="InParanoid" id="Q2GZ18"/>
    <dbReference type="OMA" id="QSEWVRY"/>
    <dbReference type="OrthoDB" id="7305308at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000086">
        <property type="entry name" value="Acetyltransferase, GNAT family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ88609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="184" mass="20443" checksum="F3E6452E6A285B15" modified="2006-03-21" version="1">MASNAPNVRQARYVPAILELIRELADYEHALDSVEATEAKLLETIAFAPSDPSSTTATGVLPQTEPTSPSKPARCLVLTTPAGVVAGMALYFYNYSTWRARPGIYLEDLYVKQSERKKGYGKRLLVELAKEVVAMRGGRLEWVVLKWNEPSIQFYESIGAKQMSEWVGMRVDGEALNKLATMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZB0</accession>
    <name>Q2GZB0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224350.1">
        <property type="nucleotide sequence ID" value="XM_001224349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZB0"/>
    <dbReference type="GeneID" id="4393111"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05136"/>
    <dbReference type="HOGENOM" id="CLU_3068503_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZB0"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="53" mass="5991" checksum="1E7E733755B14EC1" modified="2006-03-21" version="1">MPRITEYFHWNCLRGAPNRGGCPVRHSGRVEKRKESGRSDFTETISLDGSGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZC2</accession>
    <name>Q2GZC2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224338.1">
        <property type="nucleotide sequence ID" value="XM_001224337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZC2"/>
    <dbReference type="GeneID" id="4392368"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05124"/>
    <dbReference type="HOGENOM" id="CLU_3191261_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZC2"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="46" mass="4853" checksum="B8073C53D7DB6506" modified="2006-03-21" version="1">MSAQLAVDSEVGLDLGVQSPEELAGVQTGSQPDSDQETRKNARPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZX3</accession>
    <name>Q2GZX3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_04923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224137.1">
        <property type="nucleotide sequence ID" value="XM_001224136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZX3"/>
    <dbReference type="GeneID" id="4393087"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04923"/>
    <dbReference type="HOGENOM" id="CLU_2183648_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZX3"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ88304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="109" mass="12254" checksum="D936246A6C6F6955" modified="2006-03-21" version="1">MALMEIFEPPRRRAHHAIRGMGGEARLDEPGRRPYFRLGRVVDGAVGPNDVILEFVRGNVVRPNSEVNHDGLHPFLTLWQGLWQSVAFPAREKSADPVPETATLCTGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0P2</accession>
    <name>Q2H0P2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 21">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="20">CPR</shortName>
            <shortName evidence="20">P450R</shortName>
            <ecNumber evidence="20 21">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">cprA</name>
        <name evidence="24" type="ORF">CHGG_04654</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 20 21">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="20">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="20">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Endoplasmic reticulum membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Mitochondrion outer membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Cell membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20 21">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="20 21"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223868.1">
        <property type="nucleotide sequence ID" value="XM_001223867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0P2"/>
    <dbReference type="FunCoup" id="Q2H0P2">
        <property type="interactions" value="752"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H0P2"/>
    <dbReference type="GeneID" id="4392123"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04654"/>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_17_3_1"/>
    <dbReference type="InParanoid" id="Q2H0P2"/>
    <dbReference type="OMA" id="QKRYQRD"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000009">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000100">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000111">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000024">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000001">
        <property type="entry name" value="NADPH--cytochrome P450 reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03212">
        <property type="entry name" value="NCPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 20" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 20 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 20" id="KW-0274">FAD</keyword>
    <keyword evidence="3 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 20" id="KW-0288">FMN</keyword>
    <keyword evidence="2 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 20 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 20" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9 20 21" id="KW-0521">NADP</keyword>
    <keyword evidence="12 20 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 20" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="18 20" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 20" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="17 20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="22">
        <location>
            <begin position="65"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="23">
        <location>
            <begin position="273"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="71"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="448"/>
            <end position="451"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="466"/>
            <end position="468"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="483"/>
            <end position="486"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="549"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="605"/>
            <end position="606"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="611"/>
            <end position="615"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="647"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="685"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR000208"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ88035.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="686" mass="75928" checksum="37F9C49EFD8DA76D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0X5</accession>
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        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
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    <organism evidence="3 4">
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04571"/>
    <dbReference type="eggNOG" id="ENOG502SIR4">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051938_4_1_1"/>
    <dbReference type="InParanoid" id="Q2H0X5"/>
    <dbReference type="OMA" id="LHGHGTS"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF7">
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    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
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            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="282" mass="31204" checksum="02ECD16F1739D659" modified="2006-03-21" version="1">MAGESKKIRVLGLHGMGTSGHIFKTQTAAFRSKLAPDSNFTFEFLDAPFSAAPAPATDVFFTSNHLTWWESPSVDHIRRAHAFLDNYLEKHGPFDILMGFSQGCALIGSYLLYHARTTRWGPVPFKAAVFICGGLPLPALADLDVEVSQRAERLNQMTSDLLRQRTGSLAAMAGNPELIQHGVGMWDNVADLLHDPEEIPDEGDVFGLDYTTMPTDLRIRIPTVHISGGKDPRWPASWQLAYFCDKRKMYDHGGGHEIPRTTVVSNKIAGLVEELAKEIQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H107</accession>
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        <recommendedName>
            <fullName evidence="9">Nodulin-like domain-containing protein</fullName>
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        <name evidence="7" type="ORF">CHGG_04539</name>
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    <organism evidence="7 8">
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001223752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H107"/>
    <dbReference type="FunCoup" id="Q2H107">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="GeneID" id="4392332"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04539"/>
    <dbReference type="eggNOG" id="ENOG502RWDV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012596_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H107"/>
    <dbReference type="OMA" id="PDGLGCY"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF158">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 12-LIKE CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ87920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="59196" checksum="C6D07C38EE681D24" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H281</accession>
    <name>Q2H281_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223329.1">
        <property type="nucleotide sequence ID" value="XM_001223328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H281"/>
    <dbReference type="GeneID" id="4391880"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04115"/>
    <dbReference type="eggNOG" id="ENOG502S130">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_25_2_1"/>
    <dbReference type="InParanoid" id="Q2H281"/>
    <dbReference type="OMA" id="HINEWGR"/>
    <dbReference type="OrthoDB" id="6767044at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="487" mass="54577" checksum="B06EE89631FCDCD7" modified="2006-03-21" version="1">MGFPRWLVLWTRDWLTGREATLLFDGKTAAPTAIRAGVPQGSPLSPVLFILYISSLYKQLKDEHPHLAITGFADDTNLLWTEQVNLANPGGGTSPVKPEGSARFLGVWLDWKLNWKAHLVAVEKKLRTQSYALSRIVAKTWGMGLAKAREVYTKCIRSALAYGASSFHIPTDVGGEPAKKGITKALGKAQNKSLRIVAGAFKSTPIRNLETETWVPPLDLYLNKRLADFENRLQRPDLDDGRGGKKTAASVVLTACRKIQQRLSSRRGNKGRPRTLGPQGPTVVERAAETVMRWTGGTVDTNRVVEEAWKARWLKERDGRAITRPADDFDHQQETLFRNETLRRHDGLSKAKSSLLIQIRTGAIGLRDFLFTRGVPEVLTPACECGEGRETAEHLVVWCLAPPLTRRWERTGIRTRRDFYSVLHGINPTTARLARRVLDWLMDSGKLPIVRHIRSNLRGFKPFVLSLLGNESRERPITGSLQAGRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2A4</accession>
    <name>Q2H2A4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_04092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223306.1">
        <property type="nucleotide sequence ID" value="XM_001223305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2A4"/>
    <dbReference type="GeneID" id="4391919"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04092"/>
    <dbReference type="eggNOG" id="ENOG502RX5K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_9_3_1"/>
    <dbReference type="InParanoid" id="Q2H2A4"/>
    <dbReference type="OMA" id="IAYKLEG"/>
    <dbReference type="OrthoDB" id="184880at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ87473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="34957" checksum="6AF2EE5B7CFE4A64" modified="2006-03-21" version="1">MSMAVAEIPAREAKDVANLFTGTEGIYLLPHHAKEIERLREQHALILFSTGNVLVTAPLRQPKIRVLDCGASEGTWLLDLPRLYPQHEWSLHGVDIGSSLFPPKVGPCAALDLREFDIRSPTPPDPSWTQGFDLVHQRLLMWGLQKSEWATVVKNHFSLVKSGGWIQLVEGQWVDRDHPFDPVTHPNLDKMYRMQWWCTENFGMDMFIGYRLEDLLEEAGFKNVQKTQYTLGYGALAKSPEWKKRSVDMWVHTFRGLGALLPKGGIPGVLKDKAEFDQLMIDLHKETLELGYAPKMNFVIGQRPEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2F6</accession>
    <name>Q2H2F6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_04040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223254.1">
        <property type="nucleotide sequence ID" value="XM_001223253.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2H2F6">
        <property type="interactions" value="435"/>
    </dbReference>
    <dbReference type="GeneID" id="4392375"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04040"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001995_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2F6"/>
    <dbReference type="OrthoDB" id="4590285at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056021">
        <property type="entry name" value="DUF7600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF440">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24539">
        <property type="entry name" value="DUF7600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="5">
        <location>
            <begin position="951"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="732"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="819"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1269"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1323"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="736"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="749"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="827"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1290"/>
            <end position="1300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ87421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1931" mass="217412" checksum="62DEF2FDA3544B06" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2P4</accession>
    <name>Q2H2P4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Fatty acid synthase subunit beta</fullName>
            <ecNumber evidence="5">1.3.1.9</ecNumber>
            <ecNumber evidence="7">2.3.1.38</ecNumber>
            <ecNumber evidence="8">2.3.1.39</ecNumber>
            <ecNumber evidence="4">2.3.1.86</ecNumber>
            <ecNumber evidence="3">3.1.2.14</ecNumber>
            <ecNumber evidence="6">4.2.1.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="32" type="ORF">CHGG_03952</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="33" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="26">Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15057"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9924"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78783"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 28">Belongs to the fungal fatty acid synthetase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.9" evidence="5"/>
    <dbReference type="EC" id="2.3.1.38" evidence="7"/>
    <dbReference type="EC" id="2.3.1.39" evidence="8"/>
    <dbReference type="EC" id="2.3.1.86" evidence="4"/>
    <dbReference type="EC" id="3.1.2.14" evidence="3"/>
    <dbReference type="EC" id="4.2.1.59" evidence="6"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223166.1">
        <property type="nucleotide sequence ID" value="XM_001223165.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2H2P4">
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0275">Fatty acid biosynthesis</keyword>
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    <keyword evidence="11 28" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="15 28" id="KW-0520">NAD</keyword>
    <keyword evidence="13 28" id="KW-0521">NADP</keyword>
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    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 28" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="31">
        <location>
            <begin position="1699"/>
            <end position="2020"/>
        </location>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="active site" description="For acetyltransferase activity" evidence="29">
        <location>
            <position position="289"/>
        </location>
    </feature>
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        <location>
            <position position="1843"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00012878"/>
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            <dbReference type="ARBA" id="ARBA00013256"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00033756"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00058855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00068309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PIRNR" id="PIRNR005562"/>
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    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PIRSR" id="PIRSR005562-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="EAQ87333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="2111" mass="233032" checksum="D95770E2A445CB63" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2W3</accession>
    <name>Q2H2W3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase</fullName>
            <ecNumber evidence="5">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_03883</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="5"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223097.1">
        <property type="nucleotide sequence ID" value="XM_001223096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2W3"/>
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    <dbReference type="GeneID" id="4391609"/>
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    <dbReference type="eggNOG" id="KOG1329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000690_2_2_1"/>
    <dbReference type="InParanoid" id="Q2H2W3"/>
    <dbReference type="OMA" id="ILYWAHH"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
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    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
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    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF186">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="6">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="6">
        <location>
            <begin position="609"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ87264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="845" mass="96085" checksum="C8E4F6B62174552F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3E2</accession>
    <name>Q2H3E2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_03704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222918.1">
        <property type="nucleotide sequence ID" value="XM_001222917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3E2"/>
    <dbReference type="GeneID" id="4392413"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03704"/>
    <dbReference type="eggNOG" id="ENOG502T2GP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042091_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H3E2"/>
    <dbReference type="OMA" id="CECRAFA"/>
    <dbReference type="OrthoDB" id="3432781at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025213">
        <property type="entry name" value="Sim4_Fta2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13095">
        <property type="entry name" value="FTA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ87085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="323" mass="36510" checksum="29B73302B4A11E9B" modified="2006-03-21" version="1">MASSVFHLAPLPNPPVPLPRVPGPKLAPFTPNARANIEFVEFLGEKNNVDSQVWKVKIKGAGQPRLFALKTFYFCHSNFLRKNQGGDLKRPLANSQLYADYFDPFNCECRAYGRLKEAKREDLAAKAYGYLLLTPEQEADLARKVTGESTPPPDAKADKALNGHDFWRRQEEHRGLPVRAIVKELVPREALNPNVAQGMWADLKSLHSLGIFVGDTHGGNYLGGKLVDFSRSWTMYHPAMVQIRNNIRQGMMSEELQDLLDHCYFLKSSLRAIAIPDDLEAFCSGHLDEYKGLPWAYDWLKLEKNADAAEAFVEERLFERAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4E9</accession>
    <name>Q2H4E9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222561.1">
        <property type="nucleotide sequence ID" value="XM_001222560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4E9"/>
    <dbReference type="STRING" id="306901.Q2H4E9"/>
    <dbReference type="GeneID" id="4391186"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06466"/>
    <dbReference type="eggNOG" id="ENOG502SWNU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2483155_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4E9"/>
    <dbReference type="OrthoDB" id="2507450at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208798" evidence="1">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="87" mass="8900" checksum="628FFA2A6EBDF087" modified="2006-03-21" version="1">MQLTSLSLLAAWSALAVASLNVGSSGNGVGQSEFHLGVILPRQQSRTNLQVFSGALGGTGASAITNSGDPERPFEVDGDTFVCHPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4Z8</accession>
    <name>Q2H4Z8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="14">ATP-PFK</shortName>
            <shortName evidence="14">Phosphofructokinase</shortName>
            <ecNumber evidence="14">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CHGG_06267</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14 15">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="14"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222362.1">
        <property type="nucleotide sequence ID" value="XM_001222361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4Z8"/>
    <dbReference type="FunCoup" id="Q2H4Z8">
        <property type="interactions" value="958"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H4Z8"/>
    <dbReference type="GeneID" id="4391220"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06267"/>
    <dbReference type="eggNOG" id="KOG2440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011053_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4Z8"/>
    <dbReference type="OMA" id="EWQDQMC"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000007">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000008">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03184">
        <property type="entry name" value="Phosphofructokinase_I_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="9 14 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
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    <keyword evidence="8 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 15" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="6"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="16">
        <location>
            <begin position="397"/>
            <end position="664"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="381"/>
        </location>
    </feature>
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        <location>
            <begin position="397"/>
            <end position="729"/>
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    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <begin position="107"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="197"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
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        <location>
            <begin position="289"/>
            <end position="292"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
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        </ligand>
    </feature>
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        <location>
            <begin position="531"/>
            <end position="535"/>
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        <ligand>
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        </ligand>
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            <position position="569"/>
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        <ligand>
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        </ligand>
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        <location>
            <begin position="576"/>
            <end position="578"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
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        </ligand>
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            <position position="636"/>
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        </ligand>
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        <location>
            <position position="662"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
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        </ligand>
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            <position position="684"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_03184"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ89648.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="729" mass="79544" checksum="D34BF912A1173D06" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5I7</accession>
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            <fullName evidence="2">DUF7025 domain-containing protein</fullName>
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            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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            <begin position="1"/>
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            <begin position="40"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="Pfam" id="PF22942"/>
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            <dbReference type="EMBL" id="EAQ89459.1"/>
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</entry>
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    <accession>Q2H5M8</accession>
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            <fullName evidence="6">VIT domain-containing protein</fullName>
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            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <location>
            <begin position="11"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="289"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="709"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ89418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="952" mass="102862" checksum="B5312BAE8B08BA05" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5S9</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_05986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222081.1">
        <property type="nucleotide sequence ID" value="XM_001222080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5S9"/>
    <dbReference type="STRING" id="306901.Q2H5S9"/>
    <dbReference type="GeneID" id="4391046"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05986"/>
    <dbReference type="HOGENOM" id="CLU_1570442_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5S9"/>
    <dbReference type="OrthoDB" id="5239226at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="170" mass="17759" checksum="819C8662406A65F6" modified="2006-03-21" version="1">MYYHFSLLCAFRPFLGHTLDNTGIQPLEVCTQAAKSILSLTQSYDDLFTLRRVSGFMPYFITAAALFSISVEGGGGGSVGVVGDGVGGVVDGGYRLAGDGMVDGDGGERKDGDVEMGEAGEINGFGGKEEEGRLLVVPKSSTTPSTGAGDGDAQRVGFLRLLRAPSRRPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5V0</accession>
    <name>Q2H5V0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_05965</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222060.1">
        <property type="nucleotide sequence ID" value="XM_001222059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5V0"/>
    <dbReference type="FunCoup" id="Q2H5V0">
        <property type="interactions" value="907"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H5V0"/>
    <dbReference type="GeneID" id="4390810"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05965"/>
    <dbReference type="eggNOG" id="KOG0213">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002242_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H5V0"/>
    <dbReference type="OMA" id="LVMNYVW"/>
    <dbReference type="OrthoDB" id="438939at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140727">
        <property type="term" value="P:siRNA-mediated pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000066">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000069">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000810">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015016">
        <property type="entry name" value="SF3b_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08920">
        <property type="entry name" value="SF3b1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="788"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="185"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ89346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1221" mass="135647" checksum="C2F39CE14D5BF125" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5W8</accession>
    <name>Q2H5W8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_05947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222042.1">
        <property type="nucleotide sequence ID" value="XM_001222041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5W8"/>
    <dbReference type="GeneID" id="4390044"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05947"/>
    <dbReference type="HOGENOM" id="CLU_1758586_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5W8"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="148" mass="15962" checksum="856F065515B63A85" modified="2006-03-21" version="1">MDVNLDSATIRHNEDPIAQQLRNGFNGSCNGNDGINGINGINGINGINGINGKLGTVPISVCQRGIPSATHHQVLFRDWTIGRNGRPAGPCGKAVLPSAFQSFSALRCEEVDVTVKWERGIRPHPRRPETAGNVLANRQKKELCENGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5Y4</accession>
    <name>Q2H5Y4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MGS207 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222026.1">
        <property type="nucleotide sequence ID" value="XM_001222025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5Y4"/>
    <dbReference type="STRING" id="306901.Q2H5Y4"/>
    <dbReference type="GeneID" id="4390957"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05931"/>
    <dbReference type="eggNOG" id="ENOG502QVA4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036627_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5Y4"/>
    <dbReference type="OMA" id="NHWNAWK"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF6">
        <property type="entry name" value="MGS207 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="47749" checksum="3D30ADFA655EFFE9" modified="2006-03-21" version="1">MASLLSYVPLVNRLVSTGDEPQTVNLPPVEVHSVEANPDKTPRTLKHLLKANHVNHSILYHNLQFDNHLPHILCSAYHLGAESRQLYHIYDEESKTLEPWKDSPSQMAEDDWRDYLGDKRYQRAFVDFFEDALAMNHAYDWKGVIKEYMFKGEEPLINCLIGGLGHPLIHLGYAYEFDSREIAMEALGLAATQYNFLHKYSDDPSYARPAPFSSTSPLELINKLASDTRFDGLFKTPGYANIEPLFQQHESLILEYWNAWDISTPSTKSTTDLTSLFRFSQEAAVALLVATVRPGTHAYNFFVVHVLTTSHAVRILLPLMPAKWHAPLVRQWWLLALAVYIAVLRPAVDPDYVDPGDLKGRGWKYVENRALDSEWRTDAHFVKAVRAMREAARTWGDVHNRYLAAAVKFVDGFEGWVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H605</accession>
    <name>Q2H605_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222005.1">
        <property type="nucleotide sequence ID" value="XM_001222004.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4391053"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05910"/>
    <dbReference type="eggNOG" id="ENOG502SQ5Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_246760_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H605"/>
    <dbReference type="OrthoDB" id="4838614at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="892"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1430"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="905"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1079"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1157"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1183"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1245"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1281"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1291"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1316"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1432"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1447"/>
            <end position="1514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1542" mass="171409" checksum="5BFAD72FF26FDED1" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H651</accession>
    <name>Q2H651_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosome biogenesis protein NSA2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_05864</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
            <location evidence="1 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221959.1">
        <property type="nucleotide sequence ID" value="XM_001221958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H651"/>
    <dbReference type="FunCoup" id="Q2H651">
        <property type="interactions" value="1052"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H651"/>
    <dbReference type="GeneID" id="4391084"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05864"/>
    <dbReference type="eggNOG" id="KOG3163">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_831547_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H651"/>
    <dbReference type="OMA" id="TNTPEND"/>
    <dbReference type="OrthoDB" id="1847590at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ89245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="334" mass="37600" checksum="E2549573A72EE716" modified="2006-03-21" version="1">MPQNEYIERHRKLHGKRLDHEERTRKKAAREGHKQSENAQNLRGLRAKLYAKQRHAQKIQMRKAIKQHEERNVKGAPAEKEPTEAIPAYLLDRANPTTAKALSSQIKNKRAEKAARFSVPIPKVRGISEEELFKVVKTGQKVQKKGWKRVVTKPTFVGPDFTRRPVKYERFIRPMGLRYKKANVTHPTLNVTVQLPILGVKKNPSNPLIEVNVSDLGIVTASGKVAWGRYAQITNNPELFCLCARVYSVAAVMCRLGTALGLAFYAQSEPGSGKSPWETHDRGGLMPSLDRAASMIHYEPAYGASLWDTPLSPMVRGCLRLSMHRSKRPGPTMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6W2</accession>
    <name>Q2H6W2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multifunctional tryptophan biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Anthranilate synthase component 2</fullName>
                <shortName evidence="16">AS</shortName>
                <ecNumber evidence="16">4.1.3.27</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">Anthranilate synthase, glutamine amidotransferase component</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">Indole-3-glycerol phosphate synthase</fullName>
                <shortName evidence="16">IGPS</shortName>
                <ecNumber evidence="16">4.1.1.48</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
                <shortName evidence="16">PRAI</shortName>
                <ecNumber evidence="16">5.3.1.24</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CHGG_05603</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="16"/>
    <dbReference type="EC" id="4.1.1.48" evidence="16"/>
    <dbReference type="EC" id="5.3.1.24" evidence="16"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221698.1">
        <property type="nucleotide sequence ID" value="XM_001221697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6W2"/>
    <dbReference type="FunCoup" id="Q2H6W2">
        <property type="interactions" value="364"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H6W2"/>
    <dbReference type="MEROPS" id="C26.959"/>
    <dbReference type="GeneID" id="4390499"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05603"/>
    <dbReference type="eggNOG" id="KOG0026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007713_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H6W2"/>
    <dbReference type="OMA" id="EPIEWAN"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000031">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016302">
        <property type="entry name" value="Anthranilate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF4">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001382">
        <property type="entry name" value="TrpG-trpC-trpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="17">
        <location>
            <begin position="29"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="18">
        <location>
            <begin position="257"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="19">
        <location>
            <begin position="594"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR001382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EAQ88984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="770" mass="83063" checksum="D62B6379281D9C05" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H726</accession>
    <name>Q2H726_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221634.1">
        <property type="nucleotide sequence ID" value="XM_001221633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H726"/>
    <dbReference type="GeneID" id="4391037"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05539"/>
    <dbReference type="eggNOG" id="ENOG502SDNZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_569857_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H726"/>
    <dbReference type="OrthoDB" id="4776522at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="479" mass="54456" checksum="80857AAF13F18E85" modified="2006-03-21" version="1">MDSETPGRGSGLPRGIPQPLAAPRERPPQQNPNSWTPTCDHSAMAVIYEDAFQCMNCGLFPPLGTLYRCILDRESLIQDAYNDGYSVAFDSIGRYFEKEMSLGKSGPDVRSEPDSSPLTEMPEEQLSSYTPEQLSILESQRNNVHNTIANERSILEHLTSECARDKYPYDAKPWVPATKAECQYKVCSPCHRLGYERTWFREGKADLRRLRSQKYRSPPYSTTNTHPYRGRGPPRGAAKELAKIQSECLRVVAGAYKATQIRSLETETYCPPIGLYLNRRLLAFEDRVRISEEARLIRPDPCHNRCDPAAEAQKGERKTPAGDRRYSNGTSGKGLRRMEEELERWMEEAMRREWIGRWESEVARVVARNPGRALEPADATARFDASIMNRHRSRDPAWELSKAKSTLLVQARTGKSGLRGFLFTRRVPEVVTPVCRCGMARETFEHLVLECNGAADKPHPWPDDGAELLEWLDDVRRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H769</accession>
    <name>Q2H769_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_05496</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221591.1">
        <property type="nucleotide sequence ID" value="XM_001221590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H769"/>
    <dbReference type="STRING" id="306901.Q2H769"/>
    <dbReference type="GeneID" id="4390879"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05496"/>
    <dbReference type="eggNOG" id="KOG0463">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012821_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H769"/>
    <dbReference type="OMA" id="FRFIQRP"/>
    <dbReference type="OrthoDB" id="248233at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04165">
        <property type="entry name" value="GTPBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03694">
        <property type="entry name" value="GTPBP_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03708">
        <property type="entry name" value="GTPBP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000014">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000091">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035531">
        <property type="entry name" value="GTPBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF9">
        <property type="entry name" value="GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="64"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="478"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ88877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="523" mass="56926" checksum="76064B0A465D6FC9" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H778</accession>
    <name>Q2H778_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_05487</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221582.1">
        <property type="nucleotide sequence ID" value="XM_001221581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H778"/>
    <dbReference type="STRING" id="306901.Q2H778"/>
    <dbReference type="GeneID" id="4390027"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05487"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051702_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H778"/>
    <dbReference type="OMA" id="WANTITH"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000343">
        <property type="entry name" value="C2H2 transcription factor (AmdX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000576">
        <property type="entry name" value="C2H2 transcription factor (AmdX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF13">
        <property type="entry name" value="RESPIRATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="70"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ88868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="443" mass="46614" checksum="6038AC2AFCB92B6C" modified="2006-03-21" version="1">MVNTKAPAAFPPPKTDKPRPHICGTCQRSFARLEHLKRHERSHTKEKPFECPECARCFARRDLLLRHQQKLHQTTTPSSRPRNRRESASGATPGASRVRKNSVVGPGAAAAGNNAASMRPRANTISHIDNAAIQMMAAATAQTSRMPPTHSRHPSLIGLPTHHGLEAYGMASALAHRGAPLGLPKLETHGISGMDFSGGLRTAPAMPFGSEFDMEGSLFFGGSSGSTINPNALHYNDSPPSMAMDALSSFPHGLPDMSAATQSLDDFDWVTGFDHTMSFNNGPVETAVDGSSPSALSTTSQSGISDVMVDGSNHHTATAATSSMWQTSIMGPPQMSNPFALDIGGSVFPDLLNGAPVSPQPSSAKPMGETYFSTPSPSLLSSLNTQNMNQALSFGAGPETPSSMNGSNHGTLPVSTITDSTRNAILGALSASQASQFAVPDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7A1</accession>
    <name>Q2H7A1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_05464</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the secreted LysM effector family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221559.1">
        <property type="nucleotide sequence ID" value="XM_001221558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7A1"/>
    <dbReference type="STRING" id="306901.Q2H7A1"/>
    <dbReference type="GeneID" id="4391032"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05464"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010591_5_0_1"/>
    <dbReference type="InParanoid" id="Q2H7A1"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208888" description="LysM domain-containing protein" evidence="4">
        <location>
            <begin position="29"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="221"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="313"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ88845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="568" mass="62096" checksum="7C4F3DA74C118AED" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H865</accession>
    <name>Q2H865_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ketosynthase family 3 (KS3) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_03589</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230105.1">
        <property type="nucleotide sequence ID" value="XM_001230104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H865"/>
    <dbReference type="STRING" id="306901.Q2H865"/>
    <dbReference type="GeneID" id="4389729"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03589"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_16_2_1"/>
    <dbReference type="InParanoid" id="Q2H865"/>
    <dbReference type="OMA" id="CTAIFIQ"/>
    <dbReference type="OrthoDB" id="4588824at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF21">
        <property type="entry name" value="NON-REDUCING POLYKETIDE SYNTHASE AUSA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="5">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ91654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="281" mass="30062" checksum="D4CB0DF30C1044F5" modified="2006-03-21" version="1">MVRPAPVERLDLPHTGDHAKTQWWGNFLNDPDAFDHKFFKKSSREAVAWDPQQRILLEVVYEALESAGYFGPSAASEPLDYGCYIGAVMNNYYDNLSCHAGTAYATVGTSRCYLSGCMSHYFGWTGPSLTIDTACSSSLVAINTACRAIWSGECSRAVAGGTNVISSPFDYQNLAAAGFLSPSGQCKPFDADADGYCRGEAVAVVVLKPLADAVKENDNILGVIVGSAANQNHNVSQITAPHSGSQVKLYNKVMELSGVKPEDVSYIEAHGTGSKSTPLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8A4</accession>
    <name>Q2H8A4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230066.1">
        <property type="nucleotide sequence ID" value="XM_001230065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8A4"/>
    <dbReference type="STRING" id="306901.Q2H8A4"/>
    <dbReference type="GeneID" id="4388400"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03550"/>
    <dbReference type="eggNOG" id="ENOG502T4JN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1299556_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8A4"/>
    <dbReference type="OrthoDB" id="505607at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00229">
        <property type="entry name" value="SGNH_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="22996" checksum="10790BE9874E3C52" modified="2006-03-21" version="1">MADTPQTNSQSAPSTSPPPPSPHPPFPALRSIAKFKARSHATSKDIHIPLLHQIQSQPPANDNNNPYPSPTPTPKKSPTDTSRLPVRVWVVQVGTNNLTVKTGLGERDVDAWEVLVETLLGVNPTGGECKVLVTGLFYRKDVSGELVDQANGKIRAVVKRLQEKYGADRVVCLAPAAGVKTEEHLVDHVHLNLEGYQLWMAELFPAVNALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8U6</accession>
    <name>Q2H8U6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229874.1">
        <property type="nucleotide sequence ID" value="XM_001229873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8U6"/>
    <dbReference type="GeneID" id="4388638"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03358"/>
    <dbReference type="HOGENOM" id="CLU_2904007_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8U6"/>
    <dbReference type="OrthoDB" id="10511261at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="62" mass="6642" checksum="E9F9E675AB067EAB" modified="2006-03-21" version="1">MKPTMNEDVTDVSTTTTAAKLDSLTKPPIRAQPSALGKPPAQPPTTQRTKVPAGRTRDEARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9A3</accession>
    <name>Q2H9A3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dynamin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229717.1">
        <property type="nucleotide sequence ID" value="XM_001229716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9A3"/>
    <dbReference type="STRING" id="306901.Q2H9A3"/>
    <dbReference type="GeneID" id="4389071"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03201"/>
    <dbReference type="eggNOG" id="ENOG502QU12">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_550933_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9A3"/>
    <dbReference type="OMA" id="CIHARNL"/>
    <dbReference type="OrthoDB" id="3598281at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681:SF3">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin N-terminal" evidence="2">
        <location>
            <begin position="75"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="495" mass="54954" checksum="1155F8E87FBAA1E6" modified="2006-03-21" version="1">MNDSDPTSVMKLSQLQELIVSESPSKLEGGIQTGLRILSSIKKAFALAETMPEIAERVKSCDKLQAQAAPQRSVVGVVGSTGAGKSSVINAVLEEECLVPTHGMRACTAVITEISYNNSDREDQKYRAEIHFISKKQWTKELRVMLVDMADNQDALGANYKSSESEASIAYDKIRAVYPSLESEEIKDGKFDIDELLAEPLVKSLLGTVERLASSKSEDLLKLLKPFIDSQEKALGKKQPGKMGYWPLVKVVKVFVPSPILKTGLVLVDLPGSHDSNAARSAIASKYIEQCSGLWVVAPIARAADDKVAQTYLGDNFKRQLQFDGTYSRMTVICSKADDISVTEALKYLPEEAEAKQLHAHIRLLEPECKKLQEKLDILEQGETEAYGEIEQCLTYIGGLRSAIDDSADEDDVILFSPRASRKRPTREKTSKPSKRTRRQRDDDSEDSDSTLGDEPIVLEDGPEKEHISLKEAKRWLREAESHLNKLISKREELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9H1</accession>
    <name>Q2H9H1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FluG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_03133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ91198.1"/>
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    <dbReference type="OrthoDB" id="5202125at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF4">
        <property type="entry name" value="FLUG DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ91198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="765" mass="88183" checksum="B9EA03D4C064C73E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAT1</accession>
    <name>Q2HAT1_CHAGB</name>
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        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02673</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229189.1">
        <property type="nucleotide sequence ID" value="XM_001229188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAT1"/>
    <dbReference type="GeneID" id="4389246"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02673"/>
    <dbReference type="eggNOG" id="ENOG502SQUF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_973186_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HAT1"/>
    <dbReference type="OrthoDB" id="4590851at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="31269" checksum="B3EB6EE884D9F635" modified="2006-03-21" version="1">MPRDRPTFLTLPVELRLEIYTYLLVLPPPPPRETLQATYRCSYAASPSGSSLTTTNSKPTLYPQILRVNTQTYYEALPVLYGQNTFSAHPVRLTAQPTLYHPYCTPCRPVATILGTNFAPTAISGERKPALSTTNPNTHLIKKWHLRLRLDPPPATNQPSQSHNTTTNNNNNENDATRTVPAGLGASFSHADVLTLDLWRGLPAARTPNANTNTTNGNNNTNGDTDGGTTTNIVDIGVHTLLAVRAGRKKSQSWKISGNACCRDACHSNGLLVFGNGRLPVYRVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HB32</accession>
    <name>Q2HB32_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyanate hydratase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_02572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229088.1">
        <property type="nucleotide sequence ID" value="XM_001229087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HB32"/>
    <dbReference type="STRING" id="306901.Q2HB32"/>
    <dbReference type="GeneID" id="4389342"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02572"/>
    <dbReference type="eggNOG" id="ENOG502S3YJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168413_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HB32"/>
    <dbReference type="OMA" id="PIAAQMM"/>
    <dbReference type="OrthoDB" id="10019422at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008824">
        <property type="term" value="F:cyanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008076">
        <property type="entry name" value="Cyanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048564">
        <property type="entry name" value="CYNS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186:SF2">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21291">
        <property type="entry name" value="CYNS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01693">
        <property type="entry name" value="CYANASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanate hydratase N-terminal" evidence="2">
        <location>
            <begin position="37"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ90637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="117" mass="12469" checksum="893E7FC8067142EB" modified="2006-03-21" version="1">MADQRPRRGSIIDIAEQRQNLASLDSSIIDRLPAYSATLFDAKTQKRLTFEAIASHLGRSEVAVTAIFYGQARASPEDAEKLSRLLGLSAESPIAAQMMGFPDRGQGPGPIAAGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HB89</accession>
    <name>Q2HB89_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_02515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229031.1">
        <property type="nucleotide sequence ID" value="XM_001229030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HB89"/>
    <dbReference type="STRING" id="306901.Q2HB89"/>
    <dbReference type="GeneID" id="4389263"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02515"/>
    <dbReference type="eggNOG" id="ENOG502S51C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004583_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HB89"/>
    <dbReference type="OMA" id="ATWAFEA"/>
    <dbReference type="OrthoDB" id="5409589at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAR" evidence="5">
        <location>
            <begin position="669"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="354"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="571"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="633"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="747"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="659"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="748"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="804"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ90580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="944" mass="101404" checksum="C9821A9B6EBBB7C3" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBS3</accession>
    <name>Q2HBS3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_02331</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228847.1">
        <property type="nucleotide sequence ID" value="XM_001228846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBS3"/>
    <dbReference type="STRING" id="306901.Q2HBS3"/>
    <dbReference type="GeneID" id="4388424"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02331"/>
    <dbReference type="eggNOG" id="ENOG502RF91">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_642786_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HBS3"/>
    <dbReference type="OMA" id="MESIMIS"/>
    <dbReference type="OrthoDB" id="5417887at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF42">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="95"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="361"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ90396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="450" mass="48941" checksum="D291C766DC10C6EF" modified="2006-03-21" version="1">MAVRRRPQTTPSPRNGLDSGAITRIHVLGTQYRLFTEPNPTPSSPGLPANGEFDPDDYCARRLAGLETGPAPTIGPGTAASIWALFALATAFIVLRIYCKIWQSRGIWWDDLTMFLASSTLCQLVINLGFGHFPCDIPTSHHPLIAFRGGGLGSTFTVLAIVWSKTAFGITLLRLTRDRLRWALAAVVVAMNVTMGLQAVFVWVRCQPVEKNWRPGVVGTCWELGVSNGYAVFSAVLSGVCDVVFALLPWFLVWRLRMRKKEKVGVVVAMSMGVFAGITSFVKSGHIREMGSKNFTPEIATTIMASCIPVLRVLFRDLRDATPTEISGTFGLENYHYPKSDSTGVTAKQAAHDPVVVEAAAPAENGHDDNTQAPNQSDLRRSQTAPKTWRAVWDVGKSARPRARSPTGGSGTPTDNAAPAPPDIQPDNSSQRVLVNHENENRAAGLARFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HC30</accession>
    <name>Q2HC30_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Indoleamine 2,3-dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_02224</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228740.1">
        <property type="nucleotide sequence ID" value="XM_001228739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HC30"/>
    <dbReference type="STRING" id="306901.Q2HC30"/>
    <dbReference type="GeneID" id="4389027"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02224"/>
    <dbReference type="eggNOG" id="ENOG502S41S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037866_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HC30"/>
    <dbReference type="OMA" id="SHVQGFY"/>
    <dbReference type="OrthoDB" id="4662583at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF11">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ90289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="54649" checksum="078A8D6A8FC5A475" modified="2006-03-21" version="1">MFDIVGFIILSALGSFFTALAASPKKQLKLWFLASSKTIHDEPQPFSVPGVEKSDDAKLLQEINNMADCHETAALLADLIRKDGAGCWPPRAEHDHTAWPAALRPYREIYEEVAPLLPTEHVSLDDEVNKARITSFRTRLQQLLHERVDLTQVEALLAAADAGRWDVFPRDTYNAFYACVAWCRHAYRWATIPVVRLAQLEKTLPLPQELSLPWSYLQSHFGLCSESGNNTSNLVLNFTPSDTYALQINPGLSQRVTTSEEAFARVFHEVEVLGLPVYHAVVSAVLAHARGDMVGCLVQARRVAAQLRPLLSSYYDRVHDARIAKSAWLSHVQGFYAWGLGLEGEGERQQGGKEVVKFDGLSGNQVLLFQVLDAFLGIEPYLSEENLNRNVPEKQRVFCRAVERHSFRSRLRSDGVEGQIRGELGEIVKRLRLFRTAHRSRAKAYLSQPAPERLPMTAGKSLLKEDMDQSLEYLDEFMVGRLAQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCG0</accession>
    <name>Q2HCG0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">(4-O-methyl)-D-glucuronate--lignin esterase</fullName>
            <ecNumber evidence="7">3.1.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_02094</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O = 4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67452"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:171667"/>
            <dbReference type="ChEBI" id="CHEBI:171668"/>
            <dbReference type="EC" id="3.1.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:67453"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate esterase 15 (CE15) family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.117" evidence="7"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221315.1">
        <property type="nucleotide sequence ID" value="XM_001221314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCG0"/>
    <dbReference type="GeneID" id="4388118"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02094"/>
    <dbReference type="eggNOG" id="ENOG502QS8Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028869_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCG0"/>
    <dbReference type="OMA" id="HPEAYPW"/>
    <dbReference type="OrthoDB" id="3781271at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054579">
        <property type="entry name" value="GCE-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22244">
        <property type="entry name" value="GCE_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="4-O-methyl-glucuronoyl methylesterase-like" evidence="8">
        <location>
            <begin position="205"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ93859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="496" mass="52585" checksum="13D360372B14F7B5" modified="2006-03-21" version="1">MTEGATLIYTSNPFVGGCPTETLPGRRDANISGVILAIDGLTRANGPRASVVIYPDRPSPWFFALSKQSRLDRSSTETMRSLLHTLAAAAIGSAGADAHPLIPRQGGGNNTIQCPPTPSPFPTWQQLPLQSSLPDPFLPLQYTTPGDAADVVAGRGEGRVKTPEEWYQCRQPEILHMLQEYQYGYYPDHGQETVQATRSGNTLSITVAAGGKTGRFSATVTLPSGASASKPAPVVINIGGMQNQAYLSAGIAVAQFDYTSVAPDSNAKTGAFWSIYNGRDIGVLTAWAWGFHRTLDAINMTVLEIDAGRVGVTGCSRLGKAALAAGLFDTRITLTMPMSSGVQGMGPYRYYSMSGQGENLENSKQGAGWWTSSKLGAFINHSENLPYDAHTIAAAIAPRALVIDQGTGDQFVNSKGTAVVIYPAAKVVYDWLGAGDKIAISVRGGGHCDMSGFTSILPYVQKIFFGTPTSKDYNNLGSYGSPVTTAFPWGTAVPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCG3</accession>
    <name>Q2HCG3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Maintenance of telomere capping protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221312.1">
        <property type="nucleotide sequence ID" value="XM_001221311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCG3"/>
    <dbReference type="FunCoup" id="Q2HCG3">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HCG3"/>
    <dbReference type="GeneID" id="4388115"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02091"/>
    <dbReference type="eggNOG" id="ENOG502QU4J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034224_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HCG3"/>
    <dbReference type="OMA" id="RIHLVHD"/>
    <dbReference type="OrthoDB" id="5594977at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018814">
        <property type="entry name" value="DUF5427"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10310">
        <property type="entry name" value="DUF5427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="55195" checksum="1C6D62F49C01FCDF" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCX3</accession>
    <name>Q2HCX3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221152.1">
        <property type="nucleotide sequence ID" value="XM_001221151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCX3"/>
    <dbReference type="GeneID" id="4386487"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01931"/>
    <dbReference type="HOGENOM" id="CLU_1261363_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCX3"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="219" mass="23688" checksum="13B60F0A3D7501F3" modified="2006-03-21" version="1">MSNRGRGVPLQSPTPWWLAKAVGAMFPSGASHAPRRRGRAASVRKETNHPTSLWKPPQDVQLLIFLTCKRCISFAAVPLPVFKASYGASSERFDGRSCFTSGLLVRSRVSRSTSEEDPQRRQLVCGRAAVLRLLGAWARQAFVGPVSPPRARSPSEGEVFTDGFLWQHTSCDGALAACGECSISHGECSGNGYWRKGGQSALELKTHKGQGSIDSTVCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HD34</accession>
    <name>Q2HD34_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_01870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221091.1">
        <property type="nucleotide sequence ID" value="XM_001221090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HD34"/>
    <dbReference type="STRING" id="306901.Q2HD34"/>
    <dbReference type="GeneID" id="4386418"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01870"/>
    <dbReference type="eggNOG" id="ENOG502SDZT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_839367_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HD34"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ93635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="37054" checksum="BA2FBECC3689C05B" modified="2006-03-21" version="1">MELNSAAIHDVIHPTAVFNQSQASARREAPTPSKGVLWEDSQLNPKNRLDSLELPLAPLFRIDGCTGLGTQYYAVPIFLPDMPPIRFDVFIPEEAVTSPILRELLDLNVAFHTKDAPRLRRLGISAYIVRVLQAWISEGGYGTYSSLSEAMPFGSRIIFEALNFDIHKTKISVVPTYYVERQLLGVSRLDESLGVAPGLLPKAVDVGSLKILRVLYESVCLVRMPNHGPDNKNDSLWIFKALASSTKYLFVELRNLLQMEPHPNVISRPDYLVTKRCLFGGKTAVVGFLLPFHEPGSVRDTLPLLRIHNRLSLEQQVKWAHTTDVGRLAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDD5</accession>
    <name>Q2HDD5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Choline-sulfatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_01769</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220990.1">
        <property type="nucleotide sequence ID" value="XM_001220989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDD5"/>
    <dbReference type="STRING" id="306901.Q2HDD5"/>
    <dbReference type="GeneID" id="4386276"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01769"/>
    <dbReference type="eggNOG" id="KOG3867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_9_1_1"/>
    <dbReference type="InParanoid" id="Q2HDD5"/>
    <dbReference type="OMA" id="RAYFGAC"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16032">
        <property type="entry name" value="choline-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000032">
        <property type="entry name" value="Choline sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017785">
        <property type="entry name" value="Choline-sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025863">
        <property type="entry name" value="Choline_sulf_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03417">
        <property type="entry name" value="chol_sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953:SF1">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12411">
        <property type="entry name" value="Choline_sulf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="5">
        <location>
            <begin position="43"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Choline sulfatase enzyme C-terminal" evidence="6">
        <location>
            <begin position="495"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ93534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="570" mass="63830" checksum="403082651C39CC33" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDQ2</accession>
    <name>Q2HDQ2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Eburicol 14-alpha-demethylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_01652</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220873.1">
        <property type="nucleotide sequence ID" value="XM_001220872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDQ2"/>
    <dbReference type="FunCoup" id="Q2HDQ2">
        <property type="interactions" value="480"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HDQ2"/>
    <dbReference type="GeneID" id="4387772"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01652"/>
    <dbReference type="eggNOG" id="KOG0684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_15_0_1"/>
    <dbReference type="InParanoid" id="Q2HDQ2"/>
    <dbReference type="OMA" id="HWFPFVG"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008398">
        <property type="term" value="F:sterol 14-demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11042">
        <property type="entry name" value="CYP51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000033">
        <property type="entry name" value="14-alpha sterol demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="8 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ93417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="59685" checksum="ADDDD1C78A2808AA" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDV9</accession>
    <name>Q2HDV9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220816.1">
        <property type="nucleotide sequence ID" value="XM_001220815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDV9"/>
    <dbReference type="STRING" id="306901.Q2HDV9"/>
    <dbReference type="GeneID" id="4386343"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01595"/>
    <dbReference type="eggNOG" id="ENOG502QVFK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029872_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HDV9"/>
    <dbReference type="OMA" id="ANQHING"/>
    <dbReference type="OrthoDB" id="10071171at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01830">
        <property type="entry name" value="XynE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053140">
        <property type="entry name" value="GDSL_Rv0518-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43784:SF3">
        <property type="entry name" value="GDSL FAMILY LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43784">
        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209412" description="SGNH hydrolase-type esterase domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="216"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="431" mass="46185" checksum="36DE8C4CD3BD8E94" modified="2006-03-21" version="1">MSSTFGFRRFLGLALATACVPFATCHDDRWIDIWASMPQQVEPYNLPNAPYNGTDGVFQNTTIRQTVYLTQDADTIRLQFSNAFGGSDLPITAATIALPVNGTAGSPAIQPDTLQHLTFSGSPSFAVPNGALVVSDPLRFPVKAQTSLTITVYLAAGQAGHAITGHPGSRTATWLTQGNLVSAADVTTPTTQRIDKWFLASALQGWLPSHHRALAVVGDSITDGRGSTTNGNDRWPDQLVRRLQRDGNQRSVAVLNMAAGGNRILADGLGPNALGRLERDVLARGPAVKYALIYEGVNDLGTAATDAAAQARVGDRVILAYEQMITRLHGAGIAAFGGTITPMSGPGQVYGDPEREKQRQRLNEWIRTSGRFDAVVDFDKVVRDPKNGTMLKTEYDSGDYLHLNPAGYKAMADAVDLELFARFGGGVNSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HE16</accession>
    <name>Q2HE16_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_01538</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220759.1">
        <property type="nucleotide sequence ID" value="XM_001220758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HE16"/>
    <dbReference type="STRING" id="306901.Q2HE16"/>
    <dbReference type="GeneID" id="4387784"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01538"/>
    <dbReference type="eggNOG" id="KOG4157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003527_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HE16"/>
    <dbReference type="OMA" id="WYPSAMI"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF105">
        <property type="entry name" value="COPPER RADICAL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209414" description="WSC domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="34"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="146"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="245"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="390"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ93303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1005" mass="105578" checksum="3FCC135F5E63066A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HE46</accession>
    <name>Q2HE46_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 7">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_01508</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 7"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220729.1">
        <property type="nucleotide sequence ID" value="XM_001220728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HE46"/>
    <dbReference type="FunCoup" id="Q2HE46">
        <property type="interactions" value="788"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HE46"/>
    <dbReference type="GeneID" id="4388151"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01508"/>
    <dbReference type="eggNOG" id="KOG2638">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023632_3_0_1"/>
    <dbReference type="InParanoid" id="Q2HE46"/>
    <dbReference type="OMA" id="KEYCFLS"/>
    <dbReference type="OrthoDB" id="932129at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ93273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="515" mass="57208" checksum="2818EB60B3DEC491" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEL6</accession>
    <name>Q2HEL6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_01338</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220559.1">
        <property type="nucleotide sequence ID" value="XM_001220558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEL6"/>
    <dbReference type="STRING" id="306901.Q2HEL6"/>
    <dbReference type="GeneID" id="4386434"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01338"/>
    <dbReference type="eggNOG" id="ENOG502SJ9D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_342549_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HEL6"/>
    <dbReference type="OMA" id="NMIMMAR"/>
    <dbReference type="OrthoDB" id="3014581at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF90">
        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="544"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="625"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="706"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="552"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="568"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="713"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ93103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="827" mass="90267" checksum="263C1D70BEA16B66" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEP1</accession>
    <name>Q2HEP1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">xylan 1,4-beta-xylosidase</fullName>
            <ecNumber evidence="11">3.2.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_01313</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Hydrolysis of (1-&gt;4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini.</text>
            <dbReference type="EC" id="3.2.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="11"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220534.1">
        <property type="nucleotide sequence ID" value="XM_001220533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEP1"/>
    <dbReference type="STRING" id="306901.Q2HEP1"/>
    <dbReference type="GeneID" id="4388339"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01313"/>
    <dbReference type="eggNOG" id="ENOG502QQ55">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_5_3_1"/>
    <dbReference type="InParanoid" id="Q2HEP1"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF3">
        <property type="entry name" value="BETA-D-XYLOSIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209258" description="xylan 1,4-beta-xylosidase" evidence="12">
        <location>
            <begin position="23"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="13">
        <location>
            <begin position="103"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 3 C-terminal" evidence="14">
        <location>
            <begin position="403"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ93078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="549" mass="59742" checksum="2D720762E2B6D0E8" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-11-02" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEW5</accession>
    <name>CHEA_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PKS-NRPS hybrid synthetase cheA</fullName>
            <shortName evidence="9">PKS-NRPS cheA</shortName>
            <ecNumber evidence="11">2.3.1.-</ecNumber>
            <ecNumber evidence="11">6.3.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Chaetoglobosin A biosynthesis cluster protein A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Prochaetoglobin I synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cheA</name>
        <name type="ORF">CHGG_01239</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2013" name="J. Am. Chem. Soc." volume="135" first="7371" last="7377">
            <title>Combinatorial generation of complexity by redox enzymes in the chaetoglobosin A biosynthesis.</title>
            <authorList>
                <person name="Ishiuchi K."/>
                <person name="Nakazawa T."/>
                <person name="Yagishita F."/>
                <person name="Mino T."/>
                <person name="Noguchi H."/>
                <person name="Hotta K."/>
                <person name="Watanabe K."/>
            </authorList>
            <dbReference type="PubMed" id="23611317"/>
            <dbReference type="DOI" id="10.1021/ja402828w"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2021" name="Fungal Biol." volume="125" first="201" last="210">
            <title>Functional analysis of a chaetoglobosin A biosynthetic regulator in Chaetomium globosum.</title>
            <authorList>
                <person name="Cheng M."/>
                <person name="Zhao S."/>
                <person name="Liu H."/>
                <person name="Liu Y."/>
                <person name="Lin C."/>
                <person name="Song J."/>
                <person name="Thawai C."/>
                <person name="Charoensettasilp S."/>
                <person name="Yang Q."/>
            </authorList>
            <dbReference type="PubMed" id="33622536"/>
            <dbReference type="DOI" id="10.1016/j.funbio.2020.10.010"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2022" name="Synth. Syst. Biotechnol." volume="7" first="1084" last="1094">
            <title>CgVeA, a light signaling responsive regulator, is involved in regulation of chaetoglobosin A biosynthesis and conidia development in Chaetomium globosum.</title>
            <authorList>
                <person name="Wang Z."/>
                <person name="Zhao S."/>
                <person name="Zhang K."/>
                <person name="Lin C."/>
                <person name="Ru X."/>
                <person name="Yang Q."/>
            </authorList>
            <dbReference type="PubMed" id="35949485"/>
            <dbReference type="DOI" id="10.1016/j.synbio.2022.07.002"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="6 7 12">PKS-NRPS hybrid synthetase; part of the gene cluster that mediates the biosynthesis of chaetoglobosin A which has a unique inhibitory activity against actin polymerization in mammalian cells (PubMed:23611317, PubMed:33622536). Chaetoglobosin A and its intermediates are involved in the morphological differentiation of C.globosum (PubMed:33622536). The first step of the pathway is the synthesis of prochaetoglobosin I via condensation of one acetyl-CoA, 8 malonyl-CoA, and a L-tryptophan molecule by the PKS-NRPS hybrid synthetase cheA, followed by reduction of backbone double bond to install desired geometry by the enoyl reductase cheB (PubMed:23611317). Further multiple oxidation steps performed by the cytochrome P450 monooxygenases cheE and cheG, as well as by the FAD-linked oxidoreductase cheF, lead to the formation of chaetoglobosin A (PubMed:23611317). Depending on the order of action of these reductases, distinct intermediates can be identified (PubMed:23611317). Within the pathway, the cytochrome P450 monooxygenase cheE catalyzes a stereospecific epoxidation on prochaetoglobosin I, cytoglobosin D, and chaetoglobosin J intermediates (PubMed:23611317). The FAD-linked oxidoreductase cheF performs dehydrogenation of the C-20 hydroxyl groups in the 20-dihyrochaetoglobosin A and cytoglobosin D intermediates (PubMed:23611317). Finally, the cytochrome P450 monooxygenase cheG can catalyze the stereospecific dihydroxylation of prochaetoglobosin I and prochaetoglobosin IV at C-19 and C-20, respectively (PubMed:23611317). The Diels-Alderase cheD may play a role in the post-PKS-NRPS biosynthetic steps catalyzing Diels-Alder cyclization.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="induction">
        <text evidence="7 8">Expression is positively regulated by the cluster-specific transcription factor cheR that binds directly to an asymmetric direct repeat present in the promoter (PubMed:33622536). Expression is also regulated by the developmental and secondary metabolism regulator veA, but this regulation seems to be indirect, probably via cheR (PubMed:35949485).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="6">Abolishes the production of chaetoglobosin A and 20-dihyrochaetoglobosin A (PubMed:23611317).</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the C-terminal section; belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="11"/>
    <dbReference type="EC" id="6.3.2.-" evidence="11"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220460.1">
        <property type="nucleotide sequence ID" value="XM_001220459.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q2HEW5"/>
    <dbReference type="GeneID" id="4387645"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01239"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_37_5_1"/>
    <dbReference type="InParanoid" id="Q2HEW5"/>
    <dbReference type="OMA" id="VAQFGSH"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="BioCyc" id="MetaCyc:MONOMER-19094"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19532">
        <property type="entry name" value="C_PKS-NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054514">
        <property type="entry name" value="RhiE-like_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22336">
        <property type="entry name" value="RhiE-like_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0596">Phosphopantetheine</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000438205" description="PKS-NRPS hybrid synthetase cheA">
        <location>
            <begin position="1"/>
            <end position="4699"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="3">
        <location>
            <begin position="737"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="4">
        <location>
            <begin position="1644"/>
            <end position="1947"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier 1" evidence="2">
        <location>
            <begin position="3076"/>
            <end position="3153"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier 2" evidence="2">
        <location>
            <begin position="4236"/>
            <end position="4316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal acylcarrier protein transacylase domain (SAT)" evidence="1">
        <location>
            <begin position="172"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="625"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Malonyl-CoA:ACP transacylase (MAT) domain" evidence="1">
        <location>
            <begin position="1250"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="4">
        <location>
            <begin position="1644"/>
            <end position="1777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dehydratase (DH) domain" evidence="1">
        <location>
            <begin position="1645"/>
            <end position="1941"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="4">
        <location>
            <begin position="1794"/>
            <end position="1947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Methyltransferase (MT) domain" evidence="1">
        <location>
            <begin position="2050"/>
            <end position="2241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ketoreductase (KR) domain" evidence="1">
        <location>
            <begin position="2794"/>
            <end position="2967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3164"/>
            <end position="3265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Condensation (C) domain" evidence="1">
        <location>
            <begin position="3268"/>
            <end position="3696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenylation (A) domain" evidence="1">
        <location>
            <begin position="3730"/>
            <end position="4113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiolation and peptide carrier (T) domain" evidence="1">
        <location>
            <begin position="4241"/>
            <end position="4313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Reductase (R) domain" evidence="1">
        <location>
            <begin position="4367"/>
            <end position="4598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="674"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="724"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="764"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="802"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="3200"/>
            <end position="3209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="3218"/>
            <end position="3233"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="3">
        <location>
            <position position="873"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="3">
        <location>
            <position position="1012"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="3">
        <location>
            <position position="1058"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="4">
        <location>
            <position position="1676"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="4">
        <location>
            <position position="1854"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="2">
        <location>
            <position position="3113"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="2">
        <location>
            <position position="4276"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="23611317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="33622536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="35949485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="9">
        <source>
            <dbReference type="PubMed" id="33622536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="10"/>
    <evidence type="ECO:0000305" key="11">
        <source>
            <dbReference type="PubMed" id="23611317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="12">
        <source>
            <dbReference type="PubMed" id="33622536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ93004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="4699" mass="510655" checksum="C090C064D8568ED3" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HF28</accession>
    <name>Q2HF28_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220397.1">
        <property type="nucleotide sequence ID" value="XM_001220396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HF28"/>
    <dbReference type="STRING" id="306901.Q2HF28"/>
    <dbReference type="GeneID" id="4386348"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01176"/>
    <dbReference type="eggNOG" id="ENOG502SM0X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036615_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HF28"/>
    <dbReference type="OMA" id="ECPTYLN"/>
    <dbReference type="OrthoDB" id="3549121at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020915">
        <property type="entry name" value="UPF0311"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315:SF1">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="423" mass="46415" checksum="B84D255289ED1B32" modified="2006-03-21" version="1">MPRHVDQDVHTSFVEFRAGGEYSRLPVPRVVTRSRIDNDQKCVSVQCLFCQQVRAKNTTRQKQHLLQCAPYLQAHPEVALQASAASVAAASAPAPGPQGHAPPPPPHPTAHDAPHPPHASHPPPIPPIPPVVSSYGHDDVANEHTNLSFMPNPRINGSPSHSRPSLGVEGTPAAKKQKTKQSPASNLPEIPLRDVHAAFVEFRAKEDDKCMSARCIYCNQVRAKNTSRQREHLMACAGYQSVLKDKIPANNLRHQFDEDDVASSLALPAPALDLDFRMSIRVKPKLNVGSGPAGRQSWISCIGGQWAGSWGKGVLLPSGQDVQTTVKDTATRIDARYLMQTNDEHPALIICKITGWLTGERDVMERLQDPVAADNVAAHRYRLRVTMELETGDERYQEINTGTWLGSGCRRGAEIVYDAYRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFH6</accession>
    <name>Q2HFH6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Crossover junction endonuclease MUS81</fullName>
            <ecNumber evidence="14">3.1.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CHGG_01028</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with EME1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the XPF family.</text>
    </comment>
    <dbReference type="EC" id="3.1.22.-" evidence="14"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220249.1">
        <property type="nucleotide sequence ID" value="XM_001220248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFH6"/>
    <dbReference type="FunCoup" id="Q2HFH6">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HFH6"/>
    <dbReference type="GeneID" id="4387137"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01028"/>
    <dbReference type="eggNOG" id="KOG2379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014329_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HFH6"/>
    <dbReference type="OMA" id="ELGDAMW"/>
    <dbReference type="OrthoDB" id="5963188at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048257">
        <property type="term" value="F:3'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21036">
        <property type="entry name" value="WH_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20074">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000307">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000003">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000001">
        <property type="entry name" value="Putative Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033309">
        <property type="entry name" value="Mus81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047417">
        <property type="entry name" value="WHD_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047416">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451">
        <property type="entry name" value="CLASS II CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451:SF0">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21136">
        <property type="entry name" value="WHD_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 14" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="16">
        <location>
            <begin position="308"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="76"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="214"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAQ92793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="600" mass="67303" checksum="7927DDF8BCDAA13B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG38</accession>
    <name>Q2HG38_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chromatin structure-remodeling complex protein RSC7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_00816</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220037.1">
        <property type="nucleotide sequence ID" value="XM_001220036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG38"/>
    <dbReference type="STRING" id="306901.Q2HG38"/>
    <dbReference type="GeneID" id="4386258"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00816"/>
    <dbReference type="eggNOG" id="ENOG502R38T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013061_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HG38"/>
    <dbReference type="OMA" id="GPMQPGH"/>
    <dbReference type="OrthoDB" id="5598844at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597:SF5">
        <property type="entry name" value="LOCALIZATION PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="275"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="422"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="484"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="455"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="515"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="562"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="576"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="605"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="623"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ92581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="69089" checksum="F3EB7D10C959EFDD" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGI9</accession>
    <name>Q2HGI9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">MICOS complex subunit MIC12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Altered inheritance of mitochondria protein 5, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Found in mitochondrial proteome protein 51</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_00665</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MICOS complex subunit Mic12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219886.1">
        <property type="nucleotide sequence ID" value="XM_001219885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGI9"/>
    <dbReference type="GeneID" id="4386696"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00665"/>
    <dbReference type="eggNOG" id="ENOG502SC1K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056216_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGI9"/>
    <dbReference type="OrthoDB" id="4037694at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031463">
        <property type="entry name" value="Mic12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17050">
        <property type="entry name" value="AIM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ92430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="321" mass="35864" checksum="E2F7E85468C2D788" modified="2006-03-21" version="1">MGFAAGFAGGVTLTLSLTYLTLLTHSRNRQAQSAVLRSQASTLDLFIPPDIDATLPPAARRRNASAVLPDGTYRPRATLEQHHQQQQRDGSPGASFLEAAKTRWNGEVLAAVRWAQDKDWARARERAEDGVAGLFGVRLSREPVQVEEVVFVPSHAAPQGGLQQQQREQQQQQAATPSGWGLVRRQPQEEAEHHRWSDALHRAGDTTVVVAQAMREERWRLWPRRGRCAPGEGARGAVERGSGVERVHDLVGRTKAAVHLAEERAEAKADAKLLHVSDIEKALAERYDSARREEQLKKSVEETLRERYLPVEKKQSSQWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGM9</accession>
    <name>Q2HGM9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD/PDEase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219846.1">
        <property type="nucleotide sequence ID" value="XM_001219845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGM9"/>
    <dbReference type="GeneID" id="4387229"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00625"/>
    <dbReference type="eggNOG" id="ENOG502QSR7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_423884_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGM9"/>
    <dbReference type="OrthoDB" id="16547at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594:SF1">
        <property type="entry name" value="HD_PDEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03035)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="646" mass="69765" checksum="762CB30450F88AEB" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGW8</accession>
    <name>Q2HGW8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_00536</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219757.1">
        <property type="nucleotide sequence ID" value="XM_001219756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGW8"/>
    <dbReference type="STRING" id="306901.Q2HGW8"/>
    <dbReference type="GeneID" id="4387895"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00536"/>
    <dbReference type="eggNOG" id="KOG4491">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036918_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HGW8"/>
    <dbReference type="OMA" id="MSSFACC"/>
    <dbReference type="OrthoDB" id="30881at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="307"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ92301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="39754" checksum="5F4774B187B8AF8C" modified="2006-03-21" version="1">MKPIIAIPATLMLVYRAYSKKSLTPGGLLAATLTAIAHAVHPWNLPFALLVVFFLAGTRATHVKENIKANLTLKSSGGSGAEGPRNHVQVLANSLTASLFSLLHAYQLRSREQALLTSGGNDAGSLCFAWGGDLLVIGIIANYACVAADTLSSELGILATGQPRLITSLTLRKVPRGTNGGVTLTGLAAGLLGSVIVVTAAMLFLPFCSDETSGKLGGGAPWAIEERRALILGLTLWGLLGSVVDSILGGLFQTSVKDVRSGKIVEGEGGVRALVSSDAGSHHSDHEHDAAVGAKAALLHGEGKAAVEKTVPASGADARESRNKDRRPSFGDGKPSRVIENGWDLLDNNDVNFLMAFGMSVGAMAVASWYWQVPLSSVFPSA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-11" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH38</accession>
    <name>H2B_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">HTB1</name>
        <name type="ORF">CHGG_00466</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text>The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location>Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Monoubiquitinated by the UBC2-BRE1 complex to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for H3K4me and H3K79me formation. H2BK123ub1 also modulates the formation of double-strand breaks during meiosis and is a prerequisite for DNA-damage checkpoint activation.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated to form H2BS10ph during progression through meiotic prophase. May be correlated with chromosome condensation.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Acetylated by GCN5 to form H2BK11ac and H2BK16ac. H2BK16ac can also be formed by ESA1. Acetylation of N-terminal lysines and particularly formation of H2BK11acK16ac has a positive effect on transcription.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Sumoylation to form H2BK6su or H2BK7su, and probably also H2BK16su or H2BK17su, occurs preferentially near the telomeres and represses gene transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H2BK6ac = acetylated Lys-8; H2BK6su = sumoylated Lys-8; H2BK7ac = acetylated Lys-9; H2BK7su = sumoylated Lys-9; H2BS10ph = phosphorylated Ser-12; H2BK11ac = acetylated Lys-13; H2BK16ac = acetylated Lys-24; H2BK16su = sumoylated Lys-24; H2BK17su = sumoylated Lys-25; H2BK123ub1 = monoubiquitinated Lys-131.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219687.1">
        <property type="nucleotide sequence ID" value="XM_001219686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH38"/>
    <dbReference type="SMR" id="Q2HH38"/>
    <dbReference type="FunCoup" id="Q2HH38">
        <property type="interactions" value="880"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HH38"/>
    <dbReference type="GeneID" id="4388023"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00466"/>
    <dbReference type="eggNOG" id="KOG1744">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075666_1_3_1"/>
    <dbReference type="InParanoid" id="Q2HH38"/>
    <dbReference type="OMA" id="RITIEAC"/>
    <dbReference type="OrthoDB" id="10254238at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000014">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1017">Isopeptide bond</keyword>
    <keyword id="KW-0544">Nucleosome core</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0832">Ubl conjugation</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000245293" description="Histone H2B">
        <location>
            <begin position="2"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine; alternate" evidence="1">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine; alternate" evidence="1">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine; alternate" evidence="1">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate" evidence="1">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate" evidence="1">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate" evidence="1">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)" evidence="1">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" evidence="1">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="137" mass="14815" checksum="CF7A7C43AA1EC3AA" modified="2007-01-23" version="3">MAPKAADKKPASKAPATASKAPEKKDAGKKTAPSGDKKKRTKARKETYSSYIYKVLKQVHPDTGISNRAMSILNSFVNDIFERVATEASKLAAYNKKSTISSREIQTSVRLILPGELAKHAVSEGTKAVTKYSSSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH94</accession>
    <name>Q2HH94_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_00410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219631.1">
        <property type="nucleotide sequence ID" value="XM_001219630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH94"/>
    <dbReference type="FunCoup" id="Q2HH94">
        <property type="interactions" value="1205"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HH94"/>
    <dbReference type="GeneID" id="4387275"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00410"/>
    <dbReference type="eggNOG" id="KOG2908">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042989_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HH94"/>
    <dbReference type="OMA" id="SFEDYWE"/>
    <dbReference type="OrthoDB" id="1093at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040798">
        <property type="entry name" value="Rpn9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18261">
        <property type="entry name" value="Rpn9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="175"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ92175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="382" mass="43739" checksum="544A843FFE282FAE" modified="2006-03-21" version="1">MNVDTISDFLAEQRDSAPDELQHLVLEFETLWERKLWHQLTNQLIEFFNNPGSAPQRLQFYKVFVLKFADKINQLKLVDLALKAATQCRDNQERLSFMEAVVKKVDNEESQDALVFATIAVARVRLDLEDLDGARKDLDRAERVLDSFDSVETIVHAAFYGANADYYQAKADFGSYYRNALLYLACIDIKSLSPAERRSRAYDLSIAALVSSSIYNFGELLLHPILDALSEREEDKWLRELLFAFNRGDLAAYDVLANHIKSNPLLAQHARQLREKIYLAALTEAVFRRPPHDRAMTFATIAAETKVRPDEIEHLIMKALSLGLLRGTIDQVDEVAHINWVQPKVLDMKQIENMRGRLKEWDSSVNQLGNWIETVGQDVWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHB1</accession>
    <name>Q2HHB1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_00393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219614.1">
        <property type="nucleotide sequence ID" value="XM_001219613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHB1"/>
    <dbReference type="GeneID" id="4387158"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00393"/>
    <dbReference type="HOGENOM" id="CLU_2291359_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHB1"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ92158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="101" mass="10921" checksum="3E263C7B735D24B4" modified="2006-03-21" version="1">MLPAGRRFVIGAGWYGGVQRLMEHPLVVDTPTACCGMGRDGGEGPAGRLRLPILRALTTNTAFEWTQDLAGTGPVPPVCEIFCQTLAIRLRPVVEDWASTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHD1</accession>
    <name>Q2HHD1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219594.1">
        <property type="nucleotide sequence ID" value="XM_001219593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHD1"/>
    <dbReference type="GeneID" id="4387861"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00373"/>
    <dbReference type="HOGENOM" id="CLU_762901_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHD1"/>
    <dbReference type="OrthoDB" id="4899475at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="363" mass="41050" checksum="24D3FA40BDF39800" modified="2006-03-21" version="1">MDPKSALSLGRIEHTDCPKFPEDEDLEYMKEKGTILLQVIEVAGYKLEHVASVFTKAEHKLLKGERQIAVDFVRAVYFWRHNLIQETLEFYGKLSTYSNLLSKTEKTINNLDTCLKELEEAIKENEWSADLASFVSPTSVPTACPYQLFVETYLAREDIVADLREWDDDDDAGIIEEMANRLRKLLLNSNSPDLGKVGGGQPQVAAIAVHRDGNGDKSFVVGCSGPEWRGFPPVVRMVKRLRKRRLENYHSCGTDAFNALWKLVKDKGGAKPYDPTKTGSDQPKESEEARNKRREPIRQALKEMEEHESFLGKRGEVCIAFDTATWERKPACLVCYGTLGDQDPLGRTEAAKLESMDYFLGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHH6</accession>
    <name>Q2HHH6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219549.1">
        <property type="nucleotide sequence ID" value="XM_001219548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHH6"/>
    <dbReference type="GeneID" id="4387688"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00328"/>
    <dbReference type="eggNOG" id="ENOG502RMXS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_915268_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHH6"/>
    <dbReference type="OrthoDB" id="4968544at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="304" mass="33007" checksum="B84B22B5B0F21C29" modified="2006-03-21" version="1">MAISPNQQNLALTKVPTFNRPEAGAQTDNARPTPRQRWADIAKPVPPLPLDTPFIQGAIAGIDLQKKQASLANTMRQHGDLHKQYGLYGNNILVVLTSQNKRECDLLFNAARARKPNGATLIRIDHPGWSGVGNQAYEGAGAIGAHNKVLTALGNLLVMPQHVKFLKDNKIGSSVVGAVEDFIVRARGAGVDPATKELVTNCPVDWGFVVFCRVRLAADPAFRWSTAVTQGAPVPMNHCITAGRAGYEDEKKTFCKVTIGKVIGETGPENEKSWDEADWQAGLIGKSWYAMLGDALNKVRIPWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHL4</accession>
    <name>Q2HHL4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dehydrogenase FUB6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Fusaric acid biosynthesis protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_00290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219511.1">
        <property type="nucleotide sequence ID" value="XM_001219510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHL4"/>
    <dbReference type="FunCoup" id="Q2HHL4">
        <property type="interactions" value="332"/>
    </dbReference>
    <dbReference type="GeneID" id="4388342"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00290"/>
    <dbReference type="eggNOG" id="KOG1196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_29_1_1"/>
    <dbReference type="InParanoid" id="Q2HHL4"/>
    <dbReference type="OMA" id="WMSDIPQ"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="22"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00069006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00083301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ92055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="350" mass="37685" checksum="ED013C5325BAA7F3" modified="2006-03-21" version="1">MQNKTLIFKNVPTRLPVPGQDLVVEDLGFDPSAAPPPGGVTLEVLYASFDPYQRGRMRPAHIKSYSPAYELGKPIASGAVGRVLKSDADAYKPGDLVVGLLPTGEYATLAKDRLAAIQAKVHNPHGLKELGLFLGPLGMPGLTGWSSLHEIGQPKEGETIFISSAAGAVGQVVGQIAKREGLKVIGSVGSDDKLEFIIKELGFDGGFNYKKEKAADALKRLAPEGLDIYYENVGGEQLEAALDAMNDFGRIVACGMISQYNVPAEERYGVKNLFLVVSKRLTMRGFIVGDKGFADKYGKEHQEKMQQWLAEGSVKAKLHVVEGIDNAAEGLVSIFEGKNFGKAVLKIKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHY8</accession>
    <name>Q2HHY8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219387.1">
        <property type="nucleotide sequence ID" value="XM_001219386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHY8"/>
    <dbReference type="STRING" id="306901.Q2HHY8"/>
    <dbReference type="GeneID" id="4387855"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00166"/>
    <dbReference type="eggNOG" id="ENOG502RJ9J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_993967_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHY8"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585:SF1">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209475" description="Hemerythrin-like domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="31643" checksum="14F4D1A3CAADCAFE" modified="2006-03-21" version="1">MKPFAALTFLVALATASPLGVTPRESGSLEKRDTEIIYLTNCRNLVSCCTPEGHSSHIAYYPVSGQSQNGEEPASNDECTVDSSNYTWWEQDGKQCTFPTGVTFTTHIDSDAQSRPLYSWSGWGTNGYKNFNCYRDNGRKLYERSGPEWAYICNVVYYCVPHQTKYGSLQNGSRGFVRGPNPTSSSLMAALQIRPPLASRQLASTRFNVAAMSTISDVITKDHREIERCYNEVIGSKDHDHQERFGNQFTWELARHSVAEELLVYPAFEKHMCREYQVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI83</accession>
    <name>Q2HI83_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_00071</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219292.1">
        <property type="nucleotide sequence ID" value="XM_001219291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HI83"/>
    <dbReference type="GeneID" id="4387252"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00071"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001613_8_0_1"/>
    <dbReference type="InParanoid" id="Q2HI83"/>
    <dbReference type="OrthoDB" id="5059713at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF6">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="254"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="3">
        <location>
            <begin position="555"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ91836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="680" mass="76504" checksum="A5FB97A7D462D8A5" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GLX7</accession>
    <name>Q2GLX7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_11079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408038">
        <property type="protein sequence ID" value="EAQ82903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230255.1">
        <property type="nucleotide sequence ID" value="XM_001230254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GLX7"/>
    <dbReference type="GeneID" id="4397394"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_11079"/>
    <dbReference type="eggNOG" id="ENOG502SDAI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_983492_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GLX7"/>
    <dbReference type="OMA" id="PFREAWI"/>
    <dbReference type="OrthoDB" id="3692311at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ82903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="251" mass="25945" checksum="78400E5118D31563" modified="2006-03-21" version="1">MANVPSTGASCPDGGSFYICENNATEFVVCCILDPCADDSGKCPHDGLRPASFSGDNHDEIPEQECSSLSSRQNDPCIAGSCQPGYMAPARLSSNVSDRAAFIEEVMKAEVATSASTSTTATSSIGSASGFHTESTTDTTSAAAGGTVGLHTGAVVGITLASTLTAIAILTFLVFKCRGGFSELQVVAPGQFITGPVNGPISPSAQSFGPRHPFREAWIPEPTVPVFVELDGNRWTPSNGRAQPSGYMARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GME6</accession>
    <name>Q2GME6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_10858</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226125.1">
        <property type="nucleotide sequence ID" value="XM_001226124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GME6"/>
    <dbReference type="FunCoup" id="Q2GME6">
        <property type="interactions" value="758"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GME6"/>
    <dbReference type="GeneID" id="4397343"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10858"/>
    <dbReference type="eggNOG" id="KOG0877">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065898_0_2_1"/>
    <dbReference type="InParanoid" id="Q2GME6"/>
    <dbReference type="OMA" id="PYEEWSD"/>
    <dbReference type="OrthoDB" id="10253125at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045903">
        <property type="term" value="P:positive regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000002">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="9">
        <location>
            <begin position="92"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ83040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="271" mass="29349" checksum="1F49D16D8EF03695" modified="2006-03-21" version="1">MADRGTGARGGGFASRGGDRGGDRGRGGDRGRGRGGRRGGRRGGKNEEKEWQPVTKLGRLVKAGKIKSMEEIYLHSLPIKEYQIVDFFLPKLKDEVMKIKPVQKQTRAGQRTRFKAIVIIGDSEGHVGLGIKTSKEVATAIRAAIIIAKLSVIPVRRGYWGANLGLPHSLPTKESGKCGSVTVRLIPAPRGTSLVASPAVKRLLQLAGVEDAYTSSSGSTKTLENTLKATFAAVSHTYGFLTPNLWKETKLIRSPLEEFADTLRDGKRYAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMG8</accession>
    <name>Q2GMG8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Restriction of telomere capping protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_10836</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RTC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226103.1">
        <property type="nucleotide sequence ID" value="XM_001226102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMG8"/>
    <dbReference type="STRING" id="306901.Q2GMG8"/>
    <dbReference type="GeneID" id="4397096"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10836"/>
    <dbReference type="eggNOG" id="ENOG502QV3R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011918_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GMG8"/>
    <dbReference type="OMA" id="KWEFEAR"/>
    <dbReference type="OrthoDB" id="289228at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF130">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="7">
        <location>
            <begin position="296"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ83018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="579" mass="64093" checksum="F3966F5C15F052FC" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNF4</accession>
    <name>Q2GNF4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228427.1">
        <property type="nucleotide sequence ID" value="XM_001228426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNF4"/>
    <dbReference type="GeneID" id="4396199"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10500"/>
    <dbReference type="eggNOG" id="ENOG502T4H9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2759586_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNF4"/>
    <dbReference type="OrthoDB" id="4588884at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="74" mass="7944" checksum="10CEB87A9C7A0637" modified="2006-03-21" version="1">MSQGLDKTLQLLGEEQPSTGTSYSLERYLNSDGGLTERLLGGLGLDNMVSRTQTVRCKVNALADRTAQQPQGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNX7</accession>
    <name>Q2GNX7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase assembly protein COX11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_10327</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228254.1">
        <property type="nucleotide sequence ID" value="XM_001228253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNX7"/>
    <dbReference type="FunCoup" id="Q2GNX7">
        <property type="interactions" value="436"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GNX7"/>
    <dbReference type="GeneID" id="4396007"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10327"/>
    <dbReference type="eggNOG" id="KOG2540">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045000_5_3_1"/>
    <dbReference type="InParanoid" id="Q2GNX7"/>
    <dbReference type="OMA" id="NKLECFC"/>
    <dbReference type="OrthoDB" id="1704689at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005761">
        <property type="term" value="C:mitochondrial ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.370.10:FF:000001">
        <property type="entry name" value="COX11 cytochrome c oxidase assembly homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00155">
        <property type="entry name" value="CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003465">
        <property type="entry name" value="PRK05089.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005413">
        <property type="entry name" value="COX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ83923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22190" checksum="50CE0992B672174B" modified="2006-03-21" version="1">MSEVYKRRNRSTAYYTLSIILGTVALSYGSICQTTGYGGQPVRAHGTAGSGDGSPEDLASRLEPVTDARRIRVTFSSSVSDVLPWKFTPQQREVRVLPGETALAFYTATNNSDKDIVGVATYSVTPAQTAPYFSKIQCFCFEEQRLAAGETVDMPVFFYLDPDLLKDLNMRNVHTVTLNYTFFTEARYDDKGRFQGAPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GP42</accession>
    <name>Q2GP42_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_10262</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228189.1">
        <property type="nucleotide sequence ID" value="XM_001228188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GP42"/>
    <dbReference type="STRING" id="306901.Q2GP42"/>
    <dbReference type="GeneID" id="4397002"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10262"/>
    <dbReference type="eggNOG" id="KOG0737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004223_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GP42"/>
    <dbReference type="OMA" id="IFMHATD"/>
    <dbReference type="OrthoDB" id="39734at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF56">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="787"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="41"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="706"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1047"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="706"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ83858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1066" mass="117814" checksum="425D7BE06B1F495C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GP81</accession>
    <name>Q2GP81_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_10223</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228150.1">
        <property type="nucleotide sequence ID" value="XM_001228149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GP81"/>
    <dbReference type="FunCoup" id="Q2GP81">
        <property type="interactions" value="207"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GP81"/>
    <dbReference type="GeneID" id="4397052"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10223"/>
    <dbReference type="eggNOG" id="KOG1817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048162_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GP81"/>
    <dbReference type="OMA" id="QADMFEA"/>
    <dbReference type="OrthoDB" id="2392202at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF0">
        <property type="entry name" value="RIBONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="8">
        <location>
            <begin position="68"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="7">
        <location>
            <begin position="227"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ83819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="35922" checksum="E3085FD95907DB2F" modified="2006-03-21" version="1">MPKRTHSESATPLAPTIIPTTTPEHVSKRIKPSAAVTPSPQIPPWTIFTKWTSSAIVKAHPPLPPVLDSALETAALTHSGMRKNLSDPSYEQLEWIGDVYLELIASELISQTFPTLDPGRSSHYREMLVRNSTLGQFAVHYGLDKRANFPAEFGLGGRPNGTKASEKQRAKALGDIFEAYVGAIVRSDPENGMRRAAEWLKMLWGPVLERQIREEESGSRVKDRDLNPKTQLEQMIGGPGVRIEYKDLPSGGKKDRDTNQELFFVGCFLTGWGETSLQLGYGGALGKKEAGQKAAVKAMENAKLMKKFSEKRKALVAARAAQAEKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GP83</accession>
    <name>Q2GP83_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228148.1">
        <property type="nucleotide sequence ID" value="XM_001228147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GP83"/>
    <dbReference type="STRING" id="306901.Q2GP83"/>
    <dbReference type="GeneID" id="4396537"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10221"/>
    <dbReference type="eggNOG" id="ENOG502RMMR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1361263_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GP83"/>
    <dbReference type="OMA" id="QHANKLE"/>
    <dbReference type="OrthoDB" id="4900256at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ83817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="218" mass="24028" checksum="AFE831E24E14A99D" modified="2006-03-21" version="1">MPQPAQSPAGTGPNASGKIPVLNNIAPSIFVPLQDDLLTQEPPRDRVERLKRILQTIDYQREGVKENLLYMFEREKTRIVMEAAEIEKAQPPPSIKPGLALSEIDDIIANMEAPAQPGRDYNVRDVPLPVPMMVPPNASLRDKTVIQLLNVVEQGLGELEGFEKHMAGIKDRYLGVVKVLAKVAGCLLVEESLILRRNVATGGKRRCSANLKSSHMLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPG7</accession>
    <name>Q2GPG7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_10137</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228064.1">
        <property type="nucleotide sequence ID" value="XM_001228063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPG7"/>
    <dbReference type="GeneID" id="4395983"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10137"/>
    <dbReference type="eggNOG" id="ENOG502RS04">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015101_4_2_1"/>
    <dbReference type="InParanoid" id="Q2GPG7"/>
    <dbReference type="OMA" id="WGNNYHP"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050592">
        <property type="entry name" value="GDSL_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45642">
        <property type="entry name" value="GDSL ESTERASE/LIPASE EXL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45642:SF139">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208312" description="CBM1 domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="6">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ83733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="368" mass="39023" checksum="56D5DDF2CFD7066A" modified="2006-03-21" version="1">MGRSLSRTTLALLAAAPGALAADTAGLWTQCGGIGYTGPTTCVSGAYCMAYNDWYHQCIPGQATTTPATSTTLATSTRTSSTTSAASSTSSATPDDCSVQFLITFGDSYSQTGFDVKGTKPSTSNPLGNPALPGWTASGGLNWVGFLASQYNRSTLLSYNFAYGGATTNATIVPPYEPTVLSFVDQVKQFSDSIAKKPSYAPWGDNALFGVWIGVNDVGNAWWKEDYDQVVEQIMATYFGQLQILYDAGARNFALLTVPPIHRTPAVLEGSEDNQKAEAAAIAKYNDALTAGLAAFKTKNSGITSKIIDTTVPFNTALDNPTKYGSPDATCFNSDGKSCLWFNDYHPGIEINNLVAKAVSDAWKGSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPX4</accession>
    <name>Q2GPX4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_09980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227907.1">
        <property type="nucleotide sequence ID" value="XM_001227906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPX4"/>
    <dbReference type="STRING" id="306901.Q2GPX4"/>
    <dbReference type="GeneID" id="4396552"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09980"/>
    <dbReference type="eggNOG" id="KOG0615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_268621_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPX4"/>
    <dbReference type="OMA" id="ETVWGDS"/>
    <dbReference type="OrthoDB" id="448455at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="695"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="728"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="923"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="952"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ83576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1221" mass="135809" checksum="3AF5B807502290EF" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQ53</accession>
    <name>Q2GQ53_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_09901</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227828.1">
        <property type="nucleotide sequence ID" value="XM_001227827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQ53"/>
    <dbReference type="STRING" id="306901.Q2GQ53"/>
    <dbReference type="GeneID" id="4396264"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09901"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002833_2_4_1"/>
    <dbReference type="InParanoid" id="Q2GQ53"/>
    <dbReference type="OMA" id="MGLELLW"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF333">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6 12" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208335" description="chitinase" evidence="15">
        <location>
            <begin position="24"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="16">
        <location>
            <begin position="60"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="17">
        <location>
            <begin position="90"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ83497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="470" mass="51767" checksum="363050E6E3576C36" modified="2006-03-21" version="1">MLTKLAALLFGGLLLLLVQPILTQSTPDYTCSPTKPWTGICGMGPTFCAPGNCTSECNAKSECDPGWGPEWSQATNCPLNVCCSKFGFCGTSAEFCDGKTVSSPECPGGKSADQRTIGYYEGWNLGRSCGLNPTTFHIDDMGPDTAALYDRVSALKTRDPDLKVWIAVGGWAMNDPGPYRTTFSDLAKSTTAQDAFFESLITFMRKHNFDGVDLDWEYPVADDRGGLPEDFDNFVTLVRRLRERLNRTGRDYGITLTLPASYWYLRGFNLQNLEPWIDWFNVMTYDIHGTWDSTVKAIGPYAFAHTNMTEIQQALELLWRNNINPGRVVLGLGFYGRSFTMKSPDCMHSGCEFTDGARGGECTGTPGVLSASEINTIIANGATVTTDEEAGVKIVTWDSNQWVSYDDAATLKIKLDYANLRCLGGTMVWAIDLDDGTLINALGSDLSRPKNELTKPPPSIPDFETEWDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQP1</accession>
    <name>Q2GQP1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMMECR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227640.1">
        <property type="nucleotide sequence ID" value="XM_001227639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQP1"/>
    <dbReference type="FunCoup" id="Q2GQP1">
        <property type="interactions" value="964"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GQP1"/>
    <dbReference type="GeneID" id="4396100"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09713"/>
    <dbReference type="eggNOG" id="KOG3274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052828_2_1_1"/>
    <dbReference type="InParanoid" id="Q2GQP1"/>
    <dbReference type="OrthoDB" id="24630at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.150">
        <property type="entry name" value="Hypothetical protein ph0010, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF0">
        <property type="entry name" value="AMME SYNDROME CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="161" mass="18560" checksum="1D5694E800F0D65E" modified="2006-03-21" version="1">MASTVHCLFCFEALAANLEKRELMSLVEVQKSWTEYNRSDTRFNPVRAAELPSLAVAVTLLTDFEDAADAADWELGVHGLRISFRYNGRRYGATYLPDVAVEQGWTKEETLVSLMRKAGWMGRKDRWEEVELSVVRYQGRKVGLEYAEFKQWRDWVDGTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQP6</accession>
    <name>Q2GQP6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_09708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227635.1">
        <property type="nucleotide sequence ID" value="XM_001227634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQP6"/>
    <dbReference type="STRING" id="306901.Q2GQP6"/>
    <dbReference type="GeneID" id="4396095"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09708"/>
    <dbReference type="eggNOG" id="ENOG502RYMG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1326229_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQP6"/>
    <dbReference type="OrthoDB" id="202545at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044:SF1">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="207" mass="23569" checksum="68545BA9309537E3" modified="2006-03-21" version="1">MAQAAQPPPPPTRPDTTNPNNNTNGADNNIRFFGSQIGGRSVINYGYTDMPWKLMAWDIYNFFKFFWAIPYILWPLSPADSAELTLPALVVLPVWTAILFITLFFLVNRILYSLLNGEGVEYHSDPKSHWMQSNLDRLAVTFKRPILGIHNKTSGILFDVVECLIQRNWGYATKDVRVCYQIIKQKLYSSQYSKLTAPGSSDAKPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQS0</accession>
    <name>Q2GQS0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Superkiller protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_09684</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227611.1">
        <property type="nucleotide sequence ID" value="XM_001227610.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2GQS0">
        <property type="interactions" value="466"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GQS0"/>
    <dbReference type="GeneID" id="4396683"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09684"/>
    <dbReference type="eggNOG" id="KOG1127">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001688_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GQS0"/>
    <dbReference type="OMA" id="CQWELDP"/>
    <dbReference type="OrthoDB" id="421075at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039226">
        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040962">
        <property type="entry name" value="TPR_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18833">
        <property type="entry name" value="TPR_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="458"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="654"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1002"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="320"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ83280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1396" mass="153444" checksum="6C21C94C48ECC5E5" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSE0</accession>
    <name>Q2GSE0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mannose-1-phosphate guanyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">GDP-mannose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">GTP-mannose-1-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CHGG_09114</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="4"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227041.1">
        <property type="nucleotide sequence ID" value="XM_001227040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSE0"/>
    <dbReference type="FunCoup" id="Q2GSE0">
        <property type="interactions" value="1142"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GSE0"/>
    <dbReference type="GeneID" id="4394808"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09114"/>
    <dbReference type="eggNOG" id="KOG1322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSE0"/>
    <dbReference type="OMA" id="GPNCWIC"/>
    <dbReference type="OrthoDB" id="1733332at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05824">
        <property type="entry name" value="LbH_M1P_guanylylT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06425">
        <property type="entry name" value="M1P_guanylylT_B_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000017">
        <property type="entry name" value="Mannose-1-phosphate guanyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000013">
        <property type="entry name" value="mannose-1-phosphate guanyltransferase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045233">
        <property type="entry name" value="GMPPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="15">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="16">
        <location>
            <begin position="256"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAQ85100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="364" mass="39755" checksum="016E6F4C1B6816C4" modified="2006-03-21" version="1">MKALILVGGFGTRLRPLTLTLPKPLVEFGNKRMILHQIEALAAAGVTDIVLAVNYRPEIMEKYLAEYEEQFGINITISIESEPLGTAGPLKLAEAVLSKDDTPFFVLNSDITCEYPFKELAAFHKSHGDEGTIVVTKVEEPSKYGVIVHKPSHPSRIDRFVEKPVEFVGNRINAGIYIFNTSVLDRIELRPTSIEQETFPAMAADGQLHSFDLEGFWMDVGQPKDFLTGTCLYLSSLTKKGSKLLASSSEPYVHGGNVLIDPSAKIGKNCRIGPNVTIGPDVVVGDGVRLQRCVLMAGSKVKDHAWIKSTIVGWNSSVGRWARLENVTVLGDDVTIGDEIYVNGGSVLPHKTIKANVDVPAIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSE2</accession>
    <name>Q2GSE2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227039.1">
        <property type="nucleotide sequence ID" value="XM_001227038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSE2"/>
    <dbReference type="GeneID" id="4394923"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09112"/>
    <dbReference type="eggNOG" id="ENOG502SBG2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1547369_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSE2"/>
    <dbReference type="OMA" id="DPSYECY"/>
    <dbReference type="OrthoDB" id="5274873at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19144" checksum="0C58B2DDC96F3EB6" modified="2006-03-21" version="1">MGGFYMQYLETPSTFDLLAPVPPMCPVGLRTIMLGCHADCFTSPEFPHPSSFAFPQGGLCRRRGWHDPTYECYRDANGYTCLVLVNGREYQTDLEYESNTLAQENAAMRAFMVCRNFSVNGGMLARNGIVQGLPADEAGRKPKKSSRHTSTSNHGHRSRSSHHSSSSSTTSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSY2</accession>
    <name>Q2GSY2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyl hydrolase family 92 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_08922</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226849.1">
        <property type="nucleotide sequence ID" value="XM_001226848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSY2"/>
    <dbReference type="GeneID" id="4395211"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08922"/>
    <dbReference type="eggNOG" id="ENOG502QR5Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003690_4_1_1"/>
    <dbReference type="InParanoid" id="Q2GSY2"/>
    <dbReference type="OMA" id="HVFLGAN"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2080.10:FF:000001">
        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF42">
        <property type="entry name" value="PUTATIVE SUBFAMILY (AFU_ORTHOLOGUE AFUA_6G13760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="3">
        <location>
            <begin position="56"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="2">
        <location>
            <begin position="325"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="2">
        <location>
            <begin position="430"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ84908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="719" mass="79208" checksum="7C015168C70B2E1B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSY6</accession>
    <name>Q2GSY6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc-regulated transporter 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_08918</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226845.1">
        <property type="nucleotide sequence ID" value="XM_001226844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSY6"/>
    <dbReference type="GeneID" id="4395207"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08918"/>
    <dbReference type="eggNOG" id="KOG1558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027089_1_2_1"/>
    <dbReference type="InParanoid" id="Q2GSY6"/>
    <dbReference type="OMA" id="IFFACKH"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF24">
        <property type="entry name" value="FE(2+) TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ84904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="48388" checksum="E64C15CCF8E2BB79" modified="2006-03-21" version="1">MADSAEMDLMGGKPACGSGEEPGDYDLGLHVAALWASIFGAGFPVVAKKVKWVKVPAKAFFLCKHFGTGVLIATAFVHLLPTAFGSLNDPCLPDLFTDQYPAMPGVIMMGSMFCLFVVEMYLNNKMGGHSHSHGGPMGFETQSRPRPAPEQVNRGNPPPRPPRYTAADEFEIEDVEYEKRMAQKMYDEKMRDYPPRNPYADNDELSAQSEMPPWFVVFYEQYVRQRLEMINMIKAARPQQQDDVSEKRQTMITEKEVSLADSPYIDVETGRPVDPSVYRKMSMNITLLEGGILFHSVFVGMTVSITIDGFIVLLVAILFHQMFEGLGLGSRIADVPYRRGSPRPWLLVVAFGTTAPLGQAIGLIVRDTYDPNSAFGLIIVGVFNAISSGLLLYASLVDLLAEDFLSEEASRMTKKDRMMAFSFVILGAIGMSIVGAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTC5</accession>
    <name>Q2GTC5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_08779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226706.1">
        <property type="nucleotide sequence ID" value="XM_001226705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTC5"/>
    <dbReference type="GeneID" id="4395730"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08779"/>
    <dbReference type="HOGENOM" id="CLU_921337_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTC5"/>
    <dbReference type="OrthoDB" id="4587411at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="302" mass="34805" checksum="FBDA6ACD62327A16" modified="2006-03-21" version="1">MHCRNEEVRQIIKPHELVRVAIAGNKYDCFAALSLAIPVWFHHTHIVYRAIEMWELALAACLFNERRAFAETTAALIFHTESGSYLELAKKYEEIIDPILLRNIALKLAEERSRLQIKVLMHVSRTCSYASVFFRNRTWADQVIFELSATRRPGSAVAGRPRPAALKIAAVLPTRGPPACCRSDYSAQDEPRQARPAYESRAVLWPRPIPAFSRPRHTKYDNPQDLSMYLESRMPSTSRQQPPLDHEQQAYIFELFDIPGLRNRSIIDRLLVKWPSIAFVQKDIENMRARHNKKRLGGYTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTK4</accession>
    <name>Q2GTK4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_08700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226627.1">
        <property type="nucleotide sequence ID" value="XM_001226626.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GTK4"/>
    <dbReference type="GeneID" id="4394971"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08700"/>
    <dbReference type="eggNOG" id="KOG0298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000796_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTK4"/>
    <dbReference type="OMA" id="SMIPYIT"/>
    <dbReference type="OrthoDB" id="423221at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF26">
        <property type="entry name" value="FAMILY HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="899"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1180"/>
            <end position="1215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ84686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1996" mass="221832" checksum="01BF5CBBE0DA5CB0" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTK8</accession>
    <name>Q2GTK8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">D-aminoacyl-tRNA deacylase</fullName>
            <ecNumber evidence="2 6">3.1.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_08696</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a D-aminoacyl-tRNA + H2O = a tRNA + a D-alpha-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glycyl-tRNA(Ala) + H2O = tRNA(Ala) + glycine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the DTD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="2 6"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226623.1">
        <property type="nucleotide sequence ID" value="XM_001226622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTK8"/>
    <dbReference type="FunCoup" id="Q2GTK8">
        <property type="interactions" value="1357"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GTK8"/>
    <dbReference type="GeneID" id="4394979"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08696"/>
    <dbReference type="eggNOG" id="KOG3323">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076901_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GTK8"/>
    <dbReference type="OMA" id="VFGADMK"/>
    <dbReference type="OrthoDB" id="275783at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051500">
        <property type="term" value="F:D-tyrosyl-tRNA(Tyr) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.80.10:FF:000001">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="entry name" value="D-tyrosyl-tRNA(Tyr) deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00256">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472:SF5">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="D-TYROSYL-TRNA TYR DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="DTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ84682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="110" mass="12103" checksum="B5FD3E5C3455BA28" modified="2006-03-21" version="1">MAPGDTEREAESLAAKVLKLKLWDDESGGRWKKNVQDIDGEVLCVSQFTLLASTKKGNKPDFHGAMGGDDAKKLYEYFYSKVQAGYAAEKVKNGVFQAMMQVALVNDGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTR9</accession>
    <name>Q2GTR9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_08635</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226562.1">
        <property type="nucleotide sequence ID" value="XM_001226561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTR9"/>
    <dbReference type="FunCoup" id="Q2GTR9">
        <property type="interactions" value="325"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GTR9"/>
    <dbReference type="GeneID" id="4395605"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08635"/>
    <dbReference type="eggNOG" id="KOG0752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_10_9_1"/>
    <dbReference type="InParanoid" id="Q2GTR9"/>
    <dbReference type="OMA" id="INVYRIA"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="148"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="252"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ84621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="354" mass="37920" checksum="F0E359CAD295ACA8" modified="2006-03-21" version="1">MSAGRPTQSKPRPEPGPSTSTSSPPPLPPDKLTAADQFLTTISQPVVAAFCAGGVAGAVSRTVVSPARAPQNPLPDPERGARCLQAQRGQGGLLKMLEGGGLARGSCAATAPIAYPLELIANRGIYLVSEGSFSWLQQFFERHPGDSLTPLALLTCGGIAGITSVTFTYPLDIVRTRLSIQSASFAELGEKPTKLPGMWQTMGTMYKTEGGIKALYRGIIPTVTGVAPYVGLNFMTYEFVRQYLTLEGDQNPSALRKLAAGAISGAVAQTCTYPFDVLRRRFQINTMSGMGYQYKSLLDAVRVIVTQEGIKGLYKGIIPNLLKVAPSMASSWLSFELCRDFLVSLKPEEEPLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTV4</accession>
    <name>Q2GTV4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF8212 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226527.1">
        <property type="nucleotide sequence ID" value="XM_001226526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTV4"/>
    <dbReference type="STRING" id="306901.Q2GTV4"/>
    <dbReference type="GeneID" id="4395319"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08600"/>
    <dbReference type="eggNOG" id="ENOG502SHG8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_138_0_1"/>
    <dbReference type="InParanoid" id="Q2GTV4"/>
    <dbReference type="OMA" id="RDSAICY"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF12">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8212" evidence="1">
        <location>
            <begin position="229"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="284" mass="31937" checksum="12A7CD1F5645DA79" modified="2006-03-21" version="1">MRLLSTTPTAIPHLREFIGSHIPPYAILSHTWVDDGSDPPTSRRRRPVRAAGARTLRQGPARLRSSPHARRPRICVGRYVLYCYKRSSAELSEAINSMFAWHRDAEVCYVYLSDLEPGEEGDLRRDLPGCRWFSRWWTLQELVAPRKVLFFDREWNYRGSKEELAPLLYGITNIPVTVLCHQADLGDIGVARRMSWAANRETTRLEDMAYCLLGIFDVNLSLIYGEGIKAFARLQAAILQTTPDLSIFAWADTSDTCPKYAGMLATSPAPFAGNGSTGEQLGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU60</accession>
    <name>Q2GU60_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_08494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226421.1">
        <property type="nucleotide sequence ID" value="XM_001226420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GU60"/>
    <dbReference type="GeneID" id="4394823"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08494"/>
    <dbReference type="HOGENOM" id="CLU_2793777_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GU60"/>
    <dbReference type="OrthoDB" id="1697690at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="68" mass="7622" checksum="1C865020E09238D5" modified="2006-03-21" version="1">MATAEDQGDQRPYSIQQSWTIFCSTPIAGQQEKYGNLTQSYRFLDYHYWGAKESGKYPKSIAAVAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU79</accession>
    <name>Q2GU79_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucanase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_08475</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226402.1">
        <property type="nucleotide sequence ID" value="XM_001226401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GU79"/>
    <dbReference type="STRING" id="306901.Q2GU79"/>
    <dbReference type="GeneID" id="4395517"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08475"/>
    <dbReference type="eggNOG" id="ENOG502SJT6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020817_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GU79"/>
    <dbReference type="OMA" id="AYNFRNS"/>
    <dbReference type="OrthoDB" id="412382at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF1">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE CELB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208616" description="Glucanase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ84461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="441" mass="47451" checksum="C3ADDDEBE0B5B004" modified="2006-03-21" version="1">MARGAALFGLASLLLGAVNGQLPGEGEEVHPKITTYRCTKAGGCKAKTNYIVLDALAHPVHQATNEYGCGDWGQKPNATACPDKESCAKNCVMDPVSDYSAYGINTDGDSLRLQQLLDGKLVSPRVYLLDETKRRYEMLSLTGNEFTFDVDATKLPCGMNSALYLSEMKADGAQSTLNPGGAYFGTGYCDAQCYITPFINGIGNVEGKGRVLQRDGTSGEGQQAGQPHRPPPLATRRGPYLCEGAECEKEGVCDKAGCAWNPYRVNVTDYYGAGEEFKVNSNKLVTVVTQFHANRKGKLESIHRKYVQEGRVIESYVVDAPGLPSTDSMIDELCSVTGADAFMRLGAMQGMGEALTRGMVLALSIWWDEGGNMNWLDAGEAGPCNLDEGHPSEIVKVEPAPEVTFSNMRWGEIDSTYETGQDGKGKGKNGNGKGKGKDCKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV32</accession>
    <name>Q2GV32_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225828.1">
        <property type="nucleotide sequence ID" value="XM_001225827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV32"/>
    <dbReference type="STRING" id="306901.Q2GV32"/>
    <dbReference type="GeneID" id="4393175"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08172"/>
    <dbReference type="eggNOG" id="ENOG502S5JC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015147_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GV32"/>
    <dbReference type="OMA" id="KYSWMTG"/>
    <dbReference type="OrthoDB" id="21060at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="498"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="577"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="656" mass="69164" checksum="579DEAB690707591" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVF5</accession>
    <name>Q2GVF5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_08049</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225705.1">
        <property type="nucleotide sequence ID" value="XM_001225704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVF5"/>
    <dbReference type="GeneID" id="4393990"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08049"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GVF5"/>
    <dbReference type="OMA" id="SIAQTCA"/>
    <dbReference type="OrthoDB" id="4131217at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF66">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ86796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="304" mass="31735" checksum="FEBDACF1B0C14F23" modified="2006-03-21" version="1">MSDAAKRRVEAIGNQLSGSSIPAVFKVAPTGPRVADKVVIITGANSMLGIGRASAHQFAEHGAKAIYICDYDDSNLEAHKREINGLWPQVDVHTRKFDAADEKAVKEVIDDAVKQYGRLDVFFANAGTVGPHALFSEIDADDFMNVLRVNSLSVFLAAKHAAPAMQRTSPAKPAASGSIIATASVAGLRSNAGSTPYSASKAAVVSMAQTVSYQLAGTGVRVNALCPGLIETGMTAVVFDAARARGTEGKIGQLNPLKRAGHADEIARVALFLGSDESSYVNGQAWAVDGGLSAGHPYVQGRMG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVL1</accession>
    <name>ATG8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Autophagy-related protein 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Autophagy-related ubiquitin-like modifier ATG8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ATG8</name>
        <name type="ORF">CHGG_07993</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ubiquitin-like modifier involved in autophagosome formation. With ATG4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">The C-terminal 5 residues are removed by ATG4 to expose Gly-116 at the C-terminus. The c-terminal Gly is then amidated with phosphatidylethanolamine by an activating system similar to that for ubiquitin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225649.1">
        <property type="nucleotide sequence ID" value="XM_001225648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVL1"/>
    <dbReference type="SMR" id="Q2GVL1"/>
    <dbReference type="FunCoup" id="Q2GVL1">
        <property type="interactions" value="482"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GVL1"/>
    <dbReference type="GeneID" id="4393318"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07993"/>
    <dbReference type="eggNOG" id="KOG1654">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119276_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GVL1"/>
    <dbReference type="OMA" id="AVYQEHK"/>
    <dbReference type="OrthoDB" id="6738456at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16128">
        <property type="entry name" value="Ubl_ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000010">
        <property type="entry name" value="Autophagy-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="chain" id="PRO_0000317884" description="Autophagy-related protein 8">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000317885" description="Removed in mature form" evidence="1">
        <location>
            <begin position="117"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by ATG4" evidence="1">
        <location>
            <begin position="116"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="Phosphatidylethanolamine amidated glycine" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P38182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="121" mass="14098" checksum="A2C37A228E18124D" modified="2006-03-21" version="1" precursor="true">MRSKFKDEHPFEKRKAEAERIRQKYADRIPVICEKVEKSDIATIDKKKYLVPSDLTVGQFVYVIRKRIKLSPEKAIFIFVDEVLPPTAALMSSIYEEHKDEDGFLYITYSGENTFGNFETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVN8</accession>
    <name>Q2GVN8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribulokinase/uridine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_07966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225622.1">
        <property type="nucleotide sequence ID" value="XM_001225621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVN8"/>
    <dbReference type="FunCoup" id="Q2GVN8">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GVN8"/>
    <dbReference type="GeneID" id="4394387"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07966"/>
    <dbReference type="eggNOG" id="KOG3308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058668_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GVN8"/>
    <dbReference type="OMA" id="MDMEAMT"/>
    <dbReference type="OrthoDB" id="10041966at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02024">
        <property type="entry name" value="NRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ86713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="27942" checksum="4425F4228284B884" modified="2006-03-21" version="1">MDQIRTIIIGISGCSSSGKTTLARLLRDMFPDTFILHEDDFYKPESELPINQGHADWDCPEAISIPDLEAALAHVRATGTFPVSSRVPSAISPNNTLSRRSNHGCAPLTSPTPLSPPCPAILTPTPITTIFHKNYNNFQTSSHAGFLFTLRTAQLPSAQSWPTLDIKLFLRASRAAALRRRTARDGYVHMDGFWKDPPGYVEQVVWPNYVAAHRWLFEGGGCGGGQVGWRGVEGGREFWCRGLESESESGVCWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVU4</accession>
    <name>Q2GVU4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetratricopeptide repeat protein 36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTC36 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225566.1">
        <property type="nucleotide sequence ID" value="XM_001225565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVU4"/>
    <dbReference type="STRING" id="306901.Q2GVU4"/>
    <dbReference type="GeneID" id="4394372"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07910"/>
    <dbReference type="eggNOG" id="KOG4555">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074601_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GVU4"/>
    <dbReference type="OMA" id="ILYKAAR"/>
    <dbReference type="OrthoDB" id="539634at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038906">
        <property type="entry name" value="TTC36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21405">
        <property type="entry name" value="CDNA SEQUENCE BC021608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21405:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29004" checksum="23B16EC1911E095C" modified="2006-03-21" version="1">MAHVELSRRDINVLEKIKDPEFDPSLLVQVDPTLPKDPHISDPDDYQKVAQQERDIIMSIQRLEMQQAQKRSSGAPDADIAAGYRDCVSKLGQLIQDHPRYASARNNRAQALRRLYGDSVLVAGAPANSPALLQGVDDTERLEAGKTMLCDLDHAISLLTPKVAYSRLSPQAARALSNAHTQRAAVYLMTSKLLDSMSASVDAERPEAGWSKLDFEELASRDFAMGGRYGNEIAKGLAVSTNPTAKLCGQMVREAMKKEYGPGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GW65</accession>
    <name>Q2GW65_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleosome assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_07789</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225445.1">
        <property type="nucleotide sequence ID" value="XM_001225444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GW65"/>
    <dbReference type="FunCoup" id="Q2GW65">
        <property type="interactions" value="1419"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GW65"/>
    <dbReference type="GeneID" id="4393755"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07789"/>
    <dbReference type="eggNOG" id="KOG1507">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038841_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GW65"/>
    <dbReference type="OMA" id="AAECKQN"/>
    <dbReference type="OrthoDB" id="27325at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032174">
        <property type="term" value="C:cellular bud neck septin collar"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990317">
        <property type="term" value="C:Gin4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000511">
        <property type="term" value="F:H2A-H2B histone complex chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007117">
        <property type="term" value="P:budding cell bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031116">
        <property type="term" value="P:positive regulation of microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098841">
        <property type="term" value="P:protein localization to cell division site after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.90:FF:000003">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1500:FF:000001">
        <property type="entry name" value="Nucleosome assembly protein 1-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="133"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="348"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="348"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ86536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="45300" checksum="1E02C5F9B5C51BD9" modified="2006-03-21" version="1">MAEPIKNKRPDPAAPTPQNTPANAAPISSHAQQPGVSSIKEAEELTAASIFAKDPHLVSLIQGRLGSLVGRSSGYIESLPSEVKRRVAGLKGIQKDHSKLEAEFQEEVLQLEKKYFAKFTPLYEQRSAIVNGKTEPTDDQVEAGEEDEEEEEGAAIKEEKPAESAEKVSGIPEFWLSAMKNQISLAEMITDRDEGALKSLIDIRMEYLDKPGFRLIFEFADNEYFTNKIITKTYYYQNESSYGGDFIYDHADGDKIDWKAGQDLTVRIEQKKQRNKTTKQTRIVKKTVPTESFFNFFSPPKAPNDEDDDAASDIEERLELDYQLGEDIKEKLIPRAIDWFTGEALAFEELDEDDLGDFDEDDDEDEDDDDASDDHDDEEESEEEEDDGTKPKQEPTECKQS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWJ7</accession>
    <name>SLX1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Structure-specific endonuclease subunit SLX1</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">SLX1</name>
        <name type="ORF">CHGG_07657</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with SLX4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SLX1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225313.1">
        <property type="nucleotide sequence ID" value="XM_001225312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWJ7"/>
    <dbReference type="SMR" id="Q2GWJ7"/>
    <dbReference type="FunCoup" id="Q2GWJ7">
        <property type="interactions" value="344"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GWJ7"/>
    <dbReference type="GeneID" id="4393923"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07657"/>
    <dbReference type="eggNOG" id="KOG3005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030739_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GWJ7"/>
    <dbReference type="OMA" id="HNRGCDF"/>
    <dbReference type="OrthoDB" id="24645at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10455">
        <property type="entry name" value="GIY-YIG_SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03100">
        <property type="entry name" value="Endonuc_su_Slx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027520">
        <property type="entry name" value="Slx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048749">
        <property type="entry name" value="SLX1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050381">
        <property type="entry name" value="SLX1_endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208:SF10">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21202">
        <property type="entry name" value="SLX1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000383781" description="Structure-specific endonuclease subunit SLX1">
        <location>
            <begin position="1"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="10"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="SLX1-type" evidence="1">
        <location>
            <begin position="230"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03100"/>
        </source>
    </evidence>
    <sequence length="325" mass="36221" checksum="C33617389FC35C6C" modified="2006-03-21" version="1">MATVHSPIPALYTVYILRSTVRHASFYVGSTPNPPRRLSQHNGLVRGGAVRTSRGNLRPWEMIILVSGFPSATAALKFEWALNNPHLSMHIPSAERLVVSTQRNRNGRPRRPAKSLASVASSLHLLLRVPSFARWPLCVQFFNRDAFAAWEKWCAGVSLGERGLRESWKVVTDFGEGVTSGGSGEVAAAEGEDEAPAPWGIHALPLDYEPMKEYVAKGQEIFEFERQGRCVVCREEMKSGEGLHAVCTHEGCDGVGHISCWSRSFLKNNDTGSILPVQGQCPMCKEEVDWADMMKELTLRLRGQKEVDKLLKRKRKRATKKAKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWY8</accession>
    <name>Q2GWY8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_07516</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225172.1">
        <property type="nucleotide sequence ID" value="XM_001225171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWY8"/>
    <dbReference type="FunCoup" id="Q2GWY8">
        <property type="interactions" value="939"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GWY8"/>
    <dbReference type="GeneID" id="4394327"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07516"/>
    <dbReference type="eggNOG" id="KOG2086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029402_4_1_1"/>
    <dbReference type="InParanoid" id="Q2GWY8"/>
    <dbReference type="OMA" id="NKDHTDK"/>
    <dbReference type="OrthoDB" id="25887at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="UBX domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF20">
        <property type="entry name" value="NSFL1 COFACTOR P47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEP" evidence="3">
        <location>
            <begin position="217"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="330"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ86263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="40296" checksum="01D53C682B975EE1" modified="2006-03-21" version="1">MADHDTLISNFCELTSSSTEQAAEYLSASKWDIDSAVTSYYTDMEESGQAAAPAASAAAAEPEYTGPRTLDGRPAPQYATASSSSTAKKPQKRTGLATLSSLGGGHDHDDEEEDEDYDDEEDERRGPRDLFAGGEKSGLAVQDPSQRQSDSRKILGDIMNKARSSARENREAEEAAGPARARFRGTGQTLGGDGVESRTIPDPRGSAIPTATNEGPVQERVLHIWTDGFSIDDGELRRFDDPQNRADLQMIREGRAPVHLMNIQMDQRVDVKLEQHNEEYRPLPKVYRPFGGEGRRLGSPVPGEPEAPQPVTSAPAATSANQGLSTGVDESQPTLMLRIQLPDGTRLPARFNTIQTVGDVYDFIQRSSPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX05</accession>
    <name>Q2GX05_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_07499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225155.1">
        <property type="nucleotide sequence ID" value="XM_001225154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX05"/>
    <dbReference type="GeneID" id="4394407"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07499"/>
    <dbReference type="eggNOG" id="ENOG502RUFQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1315259_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GX05"/>
    <dbReference type="OMA" id="IPDSEAW"/>
    <dbReference type="OrthoDB" id="376948at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37156">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37156:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ86246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="209" mass="23063" checksum="CCCA9CE1967683DC" modified="2006-03-21" version="1">MAMLAIGAVALPPHAGRASGAEAWKENVVIPDSEAWKENVVIPNKRGASDEAWKENVVIPDSEAWKENVVIPNKRGASDEAWKENVVIPDNEAWKENVVIPNKRGASDEAWKENVVIPDSEAWKENVVIPNKRAAGDEAWKENVVIPDSEAWKENVVIPDSEAWKENVVIPNKRAAGDEAWKENVVIPEGEAWKENVVVPDKRAAGDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXD6</accession>
    <name>Q2GXD6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225024.1">
        <property type="nucleotide sequence ID" value="XM_001225023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXD6"/>
    <dbReference type="GeneID" id="4393553"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07368"/>
    <dbReference type="HOGENOM" id="CLU_1454219_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GXD6"/>
    <dbReference type="OrthoDB" id="10362020at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="186" mass="19811" checksum="47757D12F66060D1" modified="2006-03-21" version="1">MAFHGAMASDISKLHSLRAVVPERCKPPLPTLSRTFSCIPRTPVTVKDHQPQDGGRRASKRVWFAAFWARCPPVQRPVRRSAVQKASLMPARAMASPLRSMCLANKANGDTGWRSVQRPWPPGTGAEQGREAMVFRNSQSTGSNGSAGKVKVPSPPCAPHHLVAGGARDGPSEAGTARIGESLGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXD9</accession>
    <name>Q2GXD9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225021.1">
        <property type="nucleotide sequence ID" value="XM_001225020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXD9"/>
    <dbReference type="GeneID" id="4393550"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07365"/>
    <dbReference type="HOGENOM" id="CLU_1586277_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GXD9"/>
    <dbReference type="OrthoDB" id="3649348at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="168" mass="17511" checksum="84448C441BE1C745" modified="2006-03-21" version="1">MSMHLPVMPNSLNFAAQPSTPSFNNGCTMVSPNPSARSSYPDLDVIHVCLDLPTALAELPQLFSPMPTNTSTGETTNPTATPLARSSPPSPPLPASGVGSNSTHLRPSSATPRPTKRPQAVLFSHKFTRDEAHAVTDDVLGATGGPYYTTHLLLPPQGGGASPCLDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GY01</accession>
    <name>Q2GY01_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_07153</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224809.1">
        <property type="nucleotide sequence ID" value="XM_001224808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GY01"/>
    <dbReference type="STRING" id="306901.Q2GY01"/>
    <dbReference type="GeneID" id="4394288"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07153"/>
    <dbReference type="eggNOG" id="KOG0634">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_5_1"/>
    <dbReference type="InParanoid" id="Q2GY01"/>
    <dbReference type="OMA" id="QREGILC"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF1">
        <property type="entry name" value="AROMATIC AMINO ACID AMINOTRANSFERASE, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="188"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ85900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="618" mass="68033" checksum="57323CC8D3123F92" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GY35</accession>
    <name>Q2GY35_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_07119</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224775.1">
        <property type="nucleotide sequence ID" value="XM_001224774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GY35"/>
    <dbReference type="STRING" id="306901.Q2GY35"/>
    <dbReference type="GeneID" id="4393372"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07119"/>
    <dbReference type="eggNOG" id="KOG1337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_587389_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GY35"/>
    <dbReference type="OMA" id="QHIDGIF"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF34">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="101"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ85866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="555" mass="60883" checksum="EBB0CFC4D0615B8B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZG8</accession>
    <name>Q2GZG8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAM50A/XAP5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224292.1">
        <property type="nucleotide sequence ID" value="XM_001224291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZG8"/>
    <dbReference type="STRING" id="306901.Q2GZG8"/>
    <dbReference type="GeneID" id="4392324"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05078"/>
    <dbReference type="eggNOG" id="KOG2894">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037985_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZG8"/>
    <dbReference type="OMA" id="DFIWVFL"/>
    <dbReference type="OrthoDB" id="1562195at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048337">
        <property type="entry name" value="FAM50A/XAP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007005">
        <property type="entry name" value="XAP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722:SF0">
        <property type="entry name" value="PROTEIN FAM50A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722">
        <property type="entry name" value="XAP-5 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04921">
        <property type="entry name" value="XAP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM50A/XAP5 C-terminal" evidence="2">
        <location>
            <begin position="203"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="384" mass="42369" checksum="6A02CCF20654F0C3" modified="2006-03-21" version="1">MSDPSQTASRFTPQNQTTHERLSTNTVGLVALSDFRKRRAEVLEQQEREAREAALSTRANASTPDRSLTTTPNIASADNSEPERQKKKKKRAKALVSFGDDEEEEDVAGPKIVTGQGAAKKDKEKAAGNDTNNDADNNGDTGVESTSGDDHDKRRKVPAKVAVNSSVGIVPRALTKAALRREAAEREALRKEFLLLQTAVKATEIAIPFVFYDGTNTPGGVVRVKKGDFVWLFLDKSRKVGAQLGVGADKSANARRDWARVSVDDLMLVRGTMIIPHHYEFYFFIINKTMGTNNKLLFDYSAEATPTHPTADGPGAAGISRAPGLSELEGVSDDPTITKVVDRRWYQRNKHIYPANVWQDFDPEKDYSKDIRRDPGGNAFFFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZL3</accession>
    <name>Q2GZL3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_05033</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224247.1">
        <property type="nucleotide sequence ID" value="XM_001224246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZL3"/>
    <dbReference type="STRING" id="306901.Q2GZL3"/>
    <dbReference type="GeneID" id="4391830"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05033"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014490_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZL3"/>
    <dbReference type="OMA" id="MMAQANH"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000181">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000239">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="708"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="736"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="186"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="295"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="425"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="486"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="587"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="627"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="884"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="343"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="384"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="526"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="913"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ88414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="942" mass="101542" checksum="65231B55D6CEDC8B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZM1</accession>
    <name>Q2GZM1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">10 kDa heat shock protein, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_05025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224239.1">
        <property type="nucleotide sequence ID" value="XM_001224238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZM1"/>
    <dbReference type="FunCoup" id="Q2GZM1">
        <property type="interactions" value="685"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GZM1"/>
    <dbReference type="GeneID" id="4392426"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05025"/>
    <dbReference type="eggNOG" id="KOG1641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132825_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZM1"/>
    <dbReference type="OMA" id="EDFLIMR"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000002">
        <property type="entry name" value="10 kDa chaperonin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ88406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11197" checksum="BFD5D4AA15C58183" modified="2006-03-21" version="1">MATSLRSIKALVPLLDRVLVQRVKAEAKTASGIFLPESSVKELNEAKVLAVGPGALDRDGKRVPMGVNAGDKVLIPQYGGSPVKVGEEEYHLFRDSEILAKINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZQ5</accession>
    <name>Q2GZQ5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_04991</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224205.1">
        <property type="nucleotide sequence ID" value="XM_001224204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZQ5"/>
    <dbReference type="STRING" id="306901.Q2GZQ5"/>
    <dbReference type="GeneID" id="4392016"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04991"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GZQ5"/>
    <dbReference type="OMA" id="FPEGCFQ"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07102">
        <property type="entry name" value="ALDH_EDX86601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000012">
        <property type="entry name" value="NAD-dependent succinate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="4"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ88372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="467" mass="51035" checksum="E1A50FFCFFEC4A48" modified="2006-03-21" version="1">MSVETITTISPTTNEPILTRNGISSQELEQLPEIATQAFESWRKTSLEQRRDIIKKALGILDKKKDELATELTVQMGRPIAYTGGEVTTALKRAEYLLKISDDVLQDTPGEAEKGFKRFIRKVPVGPVLIIFAWNYPYLILVNALIPALLSGNSVILKPSPQTPTIVEQVAKAFSEAGLPSGVLQYFHSGSPTIIESIVRNPKVALVCFTGSVAGGLAVQGAASDRIVNVGLELGGKDPAYVREDVDIAWAAGEIVDGAVFNSGQSCCSIERVYVSEKIHDEFVIAIQDVLKGYKLGDPLDKDTHLGPVISKRSQETIEQHVKDALDKGAVNATPANETFSKLPERGNFVVPTLLTNVTHDMKIMKDETFGPVIPVMKVKGDDEAVKLMNDSEFGLTASIWTKDTDKGYELCDGVEAGTVFVNRCDFPSPDLAWTGWKNSGKGVTLSKYGFDQFVKLKSYHLKDYPK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2025-06-18" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H047</accession>
    <name>FIS1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Mitochondrial fission 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">FIS1</name>
        <name type="ORF">CHGG_04849</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FIS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224063.1">
        <property type="nucleotide sequence ID" value="XM_001224062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H047"/>
    <dbReference type="SMR" id="Q2H047"/>
    <dbReference type="FunCoup" id="Q2H047">
        <property type="interactions" value="603"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H047"/>
    <dbReference type="GeneID" id="4391845"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04849"/>
    <dbReference type="eggNOG" id="KOG3364">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104368_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H047"/>
    <dbReference type="OMA" id="QFNYAWG"/>
    <dbReference type="OrthoDB" id="421154at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12212">
        <property type="entry name" value="Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000179">
        <property type="entry name" value="Mitochondrial fission 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016543">
        <property type="entry name" value="Fis1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033745">
        <property type="entry name" value="Fis1_cytosol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028061">
        <property type="entry name" value="Fis1_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028058">
        <property type="entry name" value="Fis1_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247:SF0">
        <property type="entry name" value="MITOCHONDRIAL FISSION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14853">
        <property type="entry name" value="Fis1_TPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14852">
        <property type="entry name" value="Fis1_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008835">
        <property type="entry name" value="TPR_repeat_11_Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0802">TPR repeat</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000256182" description="Mitochondrial fission 1 protein">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="2">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="160" mass="17623" checksum="A31978FDBEC13227" modified="2006-03-21" version="1">MAQLPYAIDAETPLNPAELAVLRAQYEREGDMVGLQTKFNYAWVKLNFAPLMEQQLGVMLLAEIFRVSTERRRECLYYLGLGNYKLGNYGDARKYNDILLSKEPGNLQALNLQSLIDEKVAKEGLMGVAIVSGVAVVAGIVGECAAPEFGAEEVKTTLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0M4</accession>
    <name>Q2H0M4_CHAGB</name>
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        <recommendedName>
            <fullName evidence="2">DUF7053 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223886.1">
        <property type="nucleotide sequence ID" value="XM_001223885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0M4"/>
    <dbReference type="STRING" id="306901.Q2H0M4"/>
    <dbReference type="GeneID" id="4393002"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04672"/>
    <dbReference type="eggNOG" id="ENOG502S0IF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_523726_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H0M4"/>
    <dbReference type="OrthoDB" id="3246050at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055481">
        <property type="entry name" value="DUF7053"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117:SF2">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23155">
        <property type="entry name" value="DUF7053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7053" evidence="2">
        <location>
            <begin position="2"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="520" mass="55599" checksum="CFBDE9AEA9AEAB3B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H197</accession>
    <name>Q2H197_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_04449</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223663.1">
        <property type="nucleotide sequence ID" value="XM_001223662.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4391959"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04449"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001613_8_1_1"/>
    <dbReference type="InParanoid" id="Q2H197"/>
    <dbReference type="OMA" id="LLRICIN"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF6">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="5">
        <location>
            <begin position="287"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="4">
        <location>
            <begin position="554"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="1191"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="480"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ87830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1686" mass="193121" checksum="3614FB79AE7A2F0D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1H2</accession>
    <name>Q2H1H2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_04374</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223588.1">
        <property type="nucleotide sequence ID" value="XM_001223587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1H2"/>
    <dbReference type="GeneID" id="4393050"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04374"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_6_1"/>
    <dbReference type="InParanoid" id="Q2H1H2"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0813">Transport</keyword>
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            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="942"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1079"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1106"/>
            <end position="1126"/>
        </location>
    </feature>
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        <location>
            <begin position="633"/>
            <end position="870"/>
        </location>
    </feature>
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        <location>
            <begin position="1053"/>
            <end position="1179"/>
        </location>
    </feature>
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        <location>
            <begin position="358"/>
            <end position="413"/>
        </location>
    </feature>
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        <location>
            <begin position="426"/>
            <end position="454"/>
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        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ87755.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1201" mass="132085" checksum="F923DE8C0A81D6BE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1J3</accession>
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        </submittedName>
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        <lineage>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        </location>
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            <end position="164"/>
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            <begin position="37"/>
            <end position="52"/>
        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="164" mass="16608" checksum="8B8EF723EFEF748E" modified="2006-03-21" version="1">MSGTSGNSTRNWDDVLKHGSALGILKPDVAFPPYGGSTSGGSSGSNTGGSSGGSSYPSGGNVGSRRSPTAAWFHVETQGGPQGYLNQRLNPAADHQSHVTPACVVVCMSPRDLVSSGSSEGAVGSLACSASPSALPDAPRTRRASRCSGAARDYTESCRPESNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2C5</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
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            <authorList>
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                <person name="Untereiner W.A."/>
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                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    <dbReference type="InParanoid" id="Q2H2C5"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ87452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="85" mass="9299" checksum="667CD1111DF17754" modified="2006-03-21" version="1">MKECECNAEGSLASINPDHIKKRHAVFVGLVCTVQQEGIGIGLKNPSLSSWLARKTVCRGDASQSKYPYPEILWPGLRIGSRFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2E8</accession>
    <name>Q2H2E8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Pectinesterase</fullName>
            <ecNumber evidence="4 11">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_04048</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in maceration and soft-rotting of plant tissue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pectinesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="4 11"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223262.1">
        <property type="nucleotide sequence ID" value="XM_001223261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2E8"/>
    <dbReference type="STRING" id="306901.Q2H2E8"/>
    <dbReference type="GeneID" id="4392897"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04048"/>
    <dbReference type="eggNOG" id="ENOG502QSQ4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_473262_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2E8"/>
    <dbReference type="OrthoDB" id="2019149at2759"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000014">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF127">
        <property type="entry name" value="PECTINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005142967" description="Pectinesterase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="12">
        <location>
            <begin position="37"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ87429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="576" mass="58949" checksum="77E7037BE9D7E495" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2025-04-09" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2I4</accession>
    <name>MED4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Mediator of RNA polymerase II transcription subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Mediator complex subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MED4</name>
        <name type="ORF">CHGG_04012</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Mediator complex subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223226.1">
        <property type="nucleotide sequence ID" value="XM_001223225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2I4"/>
    <dbReference type="SMR" id="Q2H2I4"/>
    <dbReference type="STRING" id="306901.Q2H2I4"/>
    <dbReference type="GeneID" id="4391553"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04012"/>
    <dbReference type="eggNOG" id="ENOG502SCD7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057381_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H2I4"/>
    <dbReference type="OMA" id="WPLEDKI"/>
    <dbReference type="OrthoDB" id="1929813at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019258">
        <property type="entry name" value="Mediator_Med4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10018">
        <property type="entry name" value="Med4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000302075" description="Mediator of RNA polymerase II transcription subunit 4">
        <location>
            <begin position="1"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="256"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="30"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="262"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="351" mass="39082" checksum="6E36AA9E4B358D3C" modified="2006-03-21" version="1">METNLDGCFERVEKTLGSMIDSLAKNNPSQKLAEELLAAEAELSKSLKLLETHQNNNARLQQLRQETSLHDTQLKDIMSSLWNMRRELKAVPTTSNPPPGPKHQFTTSELLAYARRISRNTLPLPGVTNGVDMTPTQFSASLTEPEDSFRLQFQPTQTQTPTNSFNLSFNGTVSTPIGLSAPTPTTTNDTQPSTQLPPSQQPPPKTAPADDKLPAHLKPAVNPLHDAAFHPWPTEGQIRTGALAALQRLVDAGIEPRGYDPAEQERRRVAEEKARREAEERARLEREEAERKGREERERMAREREAARLRNAGGADGDGERRESVAVARPKPKQFTFLGADDDEDDEDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2K8</accession>
    <name>Q2H2K8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_03988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223202.1">
        <property type="nucleotide sequence ID" value="XM_001223201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2K8"/>
    <dbReference type="GeneID" id="4392091"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03988"/>
    <dbReference type="HOGENOM" id="CLU_2222965_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2K8"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ87369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="106" mass="12082" checksum="01676BCE5D2A1BB0" modified="2006-03-21" version="1">MVRVLESSLVSTSWANEPYSRYPQQQRMFGTDEIVNGLWYAFAAAQLSFMSRRDKDGSVGPREVLEGLRIPACQQHVNFPERGDAPFGFWHAMITADGLENRSIWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2Z3</accession>
    <name>Q2H2Z3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223067.1">
        <property type="nucleotide sequence ID" value="XM_001223066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2Z3"/>
    <dbReference type="GeneID" id="4392312"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03853"/>
    <dbReference type="eggNOG" id="ENOG502RP1M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_631903_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2Z3"/>
    <dbReference type="OMA" id="ARIRFIQ"/>
    <dbReference type="OrthoDB" id="3515338at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="498" mass="53157" checksum="C0E91807B603B4CC" modified="2006-03-21" version="1">MSTRKEEEMGQTKTSSTSASASVGHANEQAMLTKRHVIDDEIEFISSNPVKKMRLTEQKHDQAPQEPTKPPLLNPPPPPPPPPPPSPSPALVPLPPPAPSQPPSCPPPLPQATLVANPTTPAPTQTLDRRRSMCDANQVKAPGPDSTLETRGNSLPVFKKFFFSQSPAPAQTRPPRHSEAISPKQLPQTYRAPPDADANTAHSTLQTPSPSSTNSVTLDQISCLDFNGTPTNSPGFDVSQVFSADGGIMGSVGFGNAVSQTHAPAPINPTNTQNLVPPMTHLSSEDSLALPMATLQKQHTTKRHLPSRHESTVARQPSPMPATKNTVKPPCLHCARIRFIQNSTNHQLNFNPPLGLVHNHNNNNGAIPHPAAPTHPAPTSHPTPSPHPANHPRRHHQQQRHQQHDHHLQSSTTQSPSLLHTLPNKNTPSGGPNPLLQDMAQAIQASFPYTQVAARQGMAPETVAEVLSSLVVVPLLLRSGGGHGGGGGRFSGLPPRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H301</accession>
    <name>Q2H301_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannan endo-1,6-alpha-mannosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_03845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223059.1">
        <property type="nucleotide sequence ID" value="XM_001223058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H301"/>
    <dbReference type="STRING" id="306901.Q2H301"/>
    <dbReference type="GeneID" id="4392683"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03845"/>
    <dbReference type="eggNOG" id="ENOG502S9QC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028686_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H301"/>
    <dbReference type="OMA" id="KNAISIW"/>
    <dbReference type="OrthoDB" id="9984024at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF1">
        <property type="entry name" value="ENDO MANNANASE, GH76 FAMILY (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ87226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="36508" checksum="7390820B5FBD6F77" modified="2006-03-21" version="1">MLKELRPTILWKRPRHSKDDVRGIISNTYGGAQRVSVTAQKTLSATGLTNSSYQFQAASKRGFSEFLNDYYDDEGWWALALIRSWDVTHEQAYLNMAEHIFRDMQAGTDGTCGGGLWWSKEKSYKNAIANELYLSVAASLANRISSRKAEYTQIAKDQWAWFKKSGMINKNNLINDGLKINSDGSCVNNGMRTWSYNQGVVLGGLAELSKATGDSSYLNQAATIAKAAIVLLSDENGIIREVDKCEPNCGADGSQFKGIFVRNLHYLHKAAPQDAFRTAIQKNANSIWSKDRNSKNQLGIKWTGPPDLGDGPNASTHSSAMDVIVAALAIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H391</accession>
    <name>Q2H391_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222969.1">
        <property type="nucleotide sequence ID" value="XM_001222968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H391"/>
    <dbReference type="GeneID" id="4392483"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03755"/>
    <dbReference type="eggNOG" id="KOG3010">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049344_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H391"/>
    <dbReference type="OMA" id="SETMFFE"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF10">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="59"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="321" mass="34445" checksum="CFE3AA6E8EF1F157" modified="2006-03-21" version="1">MAEKTNGQGTIAPKESTFRSFTPEQSANYAANRLDYHPRLYNIVLSHHQSTGGQLNTVLDVGCGPGTATRSLAGLFNHAVGIDPSEGMITTARSLGGVTHANNKPIRFEVCTVEDVTAQAALEAGSVDLLTAATAAHWFDMASFWPHAARLLRPGGTVALWIGGPILVDPSMPNGVAIQAAIDGFETALDDYMVAGNRAARGLYVDLVLPWMLETPVPDFEQASFVRKEWGVGEGKEPADEYYNIQRPANVDSLALVFATASPYIRWREANPDAVGTEADPLEVMRKEIERLLQDAGMDPKTGVIKGGIGAVLLMVKKTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3L0</accession>
    <name>Q2H3L0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_06755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222850.1">
        <property type="nucleotide sequence ID" value="XM_001222849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3L0"/>
    <dbReference type="GeneID" id="4390803"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06755"/>
    <dbReference type="HOGENOM" id="CLU_1524970_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3L0"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="31"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ90136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="176" mass="19554" checksum="94B1A5176C35C2FB" modified="2006-03-21" version="1">MSEPTPEPIQSAPPGKAGTRPPTSKNTASLKKFRILMLHGYTQSGPSFATKTSALKKVLNTALKPHGLESVLIYPTAPNKLSPLELPSPDEEDKPDPEWYAWVPQGRPHGRVPASRQGHEPHRPTHCERRGGRRVLRYRDRREEGRTVCVQKGLLHGGVGIFRQPDGQDTIHDVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3W7</accession>
    <name>Q2H3W7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_06648</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the SSK1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222743.1">
        <property type="nucleotide sequence ID" value="XM_001222742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3W7"/>
    <dbReference type="STRING" id="306901.Q2H3W7"/>
    <dbReference type="GeneID" id="4390609"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06648"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008307_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3W7"/>
    <dbReference type="OMA" id="KCAMNGE"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000146">
        <property type="entry name" value="Putative two-component response regulator SSK1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="608"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="458"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="516"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="683"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="784"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="516"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="542"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="566"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="685"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="702"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00093463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ90029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="819" mass="87637" checksum="A0DCD30C77CAD472" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3W9</accession>
    <name>Q2H3W9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCD97-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_06646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222741.1">
        <property type="nucleotide sequence ID" value="XM_001222740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3W9"/>
    <dbReference type="GeneID" id="4390607"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06646"/>
    <dbReference type="eggNOG" id="ENOG502SFGZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076914_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H3W9"/>
    <dbReference type="OMA" id="EPDWASD"/>
    <dbReference type="OrthoDB" id="333176at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040233">
        <property type="entry name" value="CCD97-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018613">
        <property type="entry name" value="Ccdc97-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09747">
        <property type="entry name" value="CCD97-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCD97-like C-terminal" evidence="2">
        <location>
            <begin position="42"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ90027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="275" mass="30337" checksum="4B3C95A0C755AAD8" modified="2006-03-21" version="1">MAPRFDSPPSTPLSFSQPRPRSPRSPGRLAQIRVQNRRRAYLEKHDPLLYDSLIRRFQTPSEREAEGRKKGYARVLEGSLLRGEERLAKLREQTVERNQDDSIAITTTTTVIETTTSSTTTTNGTEAPNPTQSPSPSPFSALTASQTASLAPPPKTRAEGRAQWEEFLRDRFVRGEDADFDYAPVDADDEYDVLEREEREEAWFEDEDPGWADSGESAGESGTGRSGGDRGEGGRGEGGRERVLCGETGSAGFLGVSWVHEGVNGRETKSTGTWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H430</accession>
    <name>Q2H430_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_06585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222680.1">
        <property type="nucleotide sequence ID" value="XM_001222679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H430"/>
    <dbReference type="GeneID" id="4391091"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06585"/>
    <dbReference type="eggNOG" id="ENOG502T4W9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_736043_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H430"/>
    <dbReference type="OMA" id="THEMPEI"/>
    <dbReference type="OrthoDB" id="4565977at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031472">
        <property type="entry name" value="MAT1-1-2/MatA-2/Smr1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17043">
        <property type="entry name" value="MAT1-1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="371" mass="42846" checksum="FC7DB118122A41F9" modified="2006-03-21" version="1">MADRHRSKIVSFLGNQSSRTREIQMDRRALGLAVLRMQAQYTRSVIATEIEKFETSFEEILQTANIFLVTTERVSNSPSLVIIDQPSVVKTVCQFLAASNAILEFLDFQQKRTGFASGGDESLERQVKEAQLLVKELLTTLFLHKKAETYPGKECGLTYNEDVKVYGGFILHKYGHVDQSDVPDPEDEDEDVEKLVQYWHTENLVHPLRHVPGTAWHKFFGNLQPGPIVSPELFRERKPQPYFKLMFPTTITWLKPEISRDYDNYREMFERFHRIPGPRLSEFVRGRRLSHYFRGWKRTEEAIILCLEDMSETPCPEYDLLGRSRPEALNAEINAPELAGIALLGDDIPDVPIFLEGEVRKYCLEFDGQWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H431</accession>
    <name>Q2H431_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_06584</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222679.1">
        <property type="nucleotide sequence ID" value="XM_001222678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H431"/>
    <dbReference type="STRING" id="306901.Q2H431"/>
    <dbReference type="GeneID" id="4391090"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06584"/>
    <dbReference type="eggNOG" id="KOG0527">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1224624_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H431"/>
    <dbReference type="OMA" id="YWITSAP"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="125"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="125"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ89965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="226" mass="25372" checksum="89DE8D8D6C7D4198" modified="2006-03-21" version="1">MASRITGTKLTAIEDASPLAFVFNGNEMIVQCTANTDDEAGAISILSIALENFKKFNDGKHAVIVRPKDSTQYWITSAPYAETLDKNAYQVIKSTEIRISVPDLVPEVPTGPQGVKHQKISKLRIRRPRNQFIIYRQWMSAKIHASNPGVTAACISQIVARTWQSEEPHVKARFKALADEEDRIHKEMYPGYRYVAGRRNPQLPLSKRNLTRDPMTVAERLIAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4F2</accession>
    <name>Q2H4F2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_06463</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2005-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Giovannoni S.J."/>
                <person name="Cho J.-C."/>
                <person name="Ferriera S."/>
                <person name="Johnson J."/>
                <person name="Kravitz S."/>
                <person name="Halpern A."/>
                <person name="Remington K."/>
                <person name="Beeson K."/>
                <person name="Tran B."/>
                <person name="Rogers Y.-H."/>
                <person name="Friedman R."/>
                <person name="Venter J.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 148.51</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2006-02" db="EMBL/GenBank/DDBJ databases">
            <title>Annotation of the Chaetomium globosum CBS 148.51 Genome.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Birren B."/>
                <person name="Lander E."/>
                <person name="Galagan J."/>
                <person name="Devon K."/>
                <person name="Nusbaum C."/>
                <person name="Ma L.-J."/>
                <person name="Jaffe D."/>
                <person name="Butler J."/>
                <person name="Alvarez P."/>
                <person name="Gnerre S."/>
                <person name="Grabherr M."/>
                <person name="Kleber M."/>
                <person name="Mauceli E."/>
                <person name="Brockman W."/>
                <person name="Rounsley S."/>
                <person name="Young S."/>
                <person name="LaButti K."/>
                <person name="Pushparaj V."/>
                <person name="DeCaprio D."/>
                <person name="Crawford M."/>
                <person name="Koehrsen M."/>
                <person name="Engels R."/>
                <person name="Montgomery P."/>
                <person name="Pearson M."/>
                <person name="Howarth C."/>
                <person name="Kodira C."/>
                <person name="Yandava C."/>
                <person name="Zeng Q."/>
                <person name="Alvarado L."/>
                <person name="Oleary S."/>
                <person name="Untereiner W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06251"/>
    <dbReference type="eggNOG" id="ENOG502SKDP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_333689_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H514"/>
    <dbReference type="OrthoDB" id="4580381at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="2">
        <location>
            <begin position="665"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="856" mass="95098" checksum="AA0B5A3BD54D3B53" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5B2</accession>
    <name>Q2H5B2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_06153</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222248.1">
        <property type="nucleotide sequence ID" value="XM_001222247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5B2"/>
    <dbReference type="STRING" id="306901.Q2H5B2"/>
    <dbReference type="ESTHER" id="chagb-q2h5b2">
        <property type="family name" value="Homoserine_transacetylase"/>
    </dbReference>
    <dbReference type="GeneID" id="4390578"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06153"/>
    <dbReference type="eggNOG" id="ENOG502QR3J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028760_7_0_1"/>
    <dbReference type="InParanoid" id="Q2H5B2"/>
    <dbReference type="OMA" id="HPILVMG"/>
    <dbReference type="OrthoDB" id="444135at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF16">
        <property type="entry name" value="SERINE O-SUCCINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="132"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="359"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ89534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="491" mass="53294" checksum="CE091F7A1E0E4436" modified="2006-03-21" version="1">MKSQRVTSTLRHAKTVFTTAAVPRRPVHHHTVKPACPNAARYLHGQATRRSGAPSNPAIKFPCLDALETRSATLEQQASTRSDKSGPEPSYTVGATQTYRCQDPLLLDHGGQLHEFDIAYETWGQMNAARSNVILLHTGLSASSHAHSTPENPQPGWWEKFIGPGLALDTNKYFVICTNVIGGCYGSTGPSSIDPLDGQRYATRFPILTIQDMVRAQFRLLDHLGVETLHASVGSSMGGMQSLAAGVEFPTRVGRIVSISACARSHPYSIAMRYVQRRAILNDPNWNRGFYYGRVPPHVGMKLAREIATITYRSGPEWEQRFGRRRADGLLYVSKAMDLFDLGRANQLATAARRAERALLSASDSPNDPSPGGGTCSLTLPDKPYEEQPQQPDPTPGTTNPTTPGMGTPTPPADLIAGLGVLRSHPVLVLGVASDILFPAWQQREVAEALRAAGNAQVEHHELSEVQSLFGHDTFLLDVEGVGGQVRGFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5G3</accession>
    <name>Q2H5G3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_06102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222197.1">
        <property type="nucleotide sequence ID" value="XM_001222196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5G3"/>
    <dbReference type="STRING" id="306901.Q2H5G3"/>
    <dbReference type="GeneID" id="4390741"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06102"/>
    <dbReference type="eggNOG" id="ENOG502SWYF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062451_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5G3"/>
    <dbReference type="OMA" id="GWDFAIL"/>
    <dbReference type="OrthoDB" id="3499003at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="35809" checksum="80BBD81EDBBB129C" modified="2006-03-21" version="1">MDPSTHQGSPSQPPPGSHDSNDNDHTQHRVRFAEGEPQASYTIHQPTPKREQHHAAASVAAPPAVYWDNKKHNDSDRESDANLAGYTFYREGTPPPPDYEGPGKRLGRGGPGTIGESSTVGGGTIRSNGDYSIGPLNPLETNWSQNDGNNPPPTKRRKVLWAIIAAAVLVIVAIAVGLGVGLGVGLPKQKGAHADAVEQPTSSILVSGPSNSPAPTDPPTNAPGGTGAAAGATTGSAAAPRPTYNSDCPALNNTVYNVPGSTISFRRVCGIDYSGDGATDLAHAWTDSMADCMNSCASFNQCTACAWGYLEGDRGGKHRCYMKTDLKKSHKAASDWCFAILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5I2</accession>
    <name>Q2H5I2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_06083</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222178.1">
        <property type="nucleotide sequence ID" value="XM_001222177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5I2"/>
    <dbReference type="GeneID" id="4391434"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06083"/>
    <dbReference type="eggNOG" id="KOG1807">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001066_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H5I2"/>
    <dbReference type="OMA" id="EWIMVEA"/>
    <dbReference type="OrthoDB" id="409395at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057373">
        <property type="entry name" value="ZNFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25396">
        <property type="entry name" value="ZNFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZNFX1" evidence="5">
        <location>
            <begin position="103"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="3">
        <location>
            <begin position="296"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="4">
        <location>
            <begin position="692"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1028"/>
            <end position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ89464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1126" mass="127255" checksum="96376ADC7A1CFBF4" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5Q8</accession>
    <name>Q2H5Q8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_06007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222102.1">
        <property type="nucleotide sequence ID" value="XM_001222101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5Q8"/>
    <dbReference type="GeneID" id="4390543"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06007"/>
    <dbReference type="eggNOG" id="ENOG502T211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3069186_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5Q8"/>
    <dbReference type="OMA" id="HFLRTEM"/>
    <dbReference type="OrthoDB" id="3443409at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="55" mass="6216" checksum="B180E389162B10AD" modified="2006-03-21" version="1">MCDFTKNYYIYTSCVDPGAHFFRTSVDGSRKRSCPNGPHERYIMLPGECPICHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5V9</accession>
    <name>Q2H5V9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222051.1">
        <property type="nucleotide sequence ID" value="XM_001222050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5V9"/>
    <dbReference type="STRING" id="306901.Q2H5V9"/>
    <dbReference type="GeneID" id="4390175"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05956"/>
    <dbReference type="eggNOG" id="KOG1492">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048898_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5V9"/>
    <dbReference type="OMA" id="CKRFTST"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156">
        <property type="entry name" value="CCCH ZINGC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156:SF1">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="46976" checksum="FB6D6172104FF80F" modified="2006-03-21" version="1">MASIEDREVMERIGRLAGQINRHKNQQAGVAPARHARTHHRMSTGRPIYYHAGTDAFQDAGYSTGWRRGGFPHRGGHSSARMPVYRNRSLVLNNGTQQNQPGDAESGTTSDASTSSWVTKNDRHLQLINTNVYAKDTQARTAAIEQTRRQKLVLRDRQERARLTNHINRMVNSGGFAGANQQVAGKYEITVQGVRFLVVSNGSKLVKVPGASQPSTTTPQDAHIGTGDNNSAKATPKMALVGGVKFYRSKNGNLYRHGIVKAQRYVSWDLGAGQLTPGFSGRQSGAVKKVNMPCKQFSMTGNIISSTDVPNNTTPLAGLRDFGFYGYCQKGASCPDRHVFECPDFSNTGVCKIKGCKLPHRERASVLRKGAGGRDLSSAGDGDEEMADLSSDDDGESIDEDDVDSDEVDEFIGHDENGGLDFADQKDFIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H640</accession>
    <name>Q2H640_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221970.1">
        <property type="nucleotide sequence ID" value="XM_001221969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H640"/>
    <dbReference type="GeneID" id="4390771"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05875"/>
    <dbReference type="HOGENOM" id="CLU_2359513_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H640"/>
    <dbReference type="OrthoDB" id="4568188at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208558" evidence="1">
        <location>
            <begin position="25"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="96" mass="10105" checksum="C30D630C040ED190" modified="2006-03-21" version="1">MVSFTTLLTATLATLAAASPATRALKPRQSDCQAVRDAIAANNWPCNEVAAPSCEFCCESWLNLEGAFGNPPCHEDHGDFTCPAGSEGYHCAADSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7K1</accession>
    <name>Q2H7K1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_05364</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221459.1">
        <property type="nucleotide sequence ID" value="XM_001221458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7K1"/>
    <dbReference type="GeneID" id="4390429"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05364"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032053_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7K1"/>
    <dbReference type="OMA" id="WERRYDS"/>
    <dbReference type="OrthoDB" id="4589408at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clr5" evidence="5">
        <location>
            <begin position="10"/>
            <end position="59"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="604" mass="66100" checksum="771E603B252F89C0" modified="2006-03-21" version="1"> </sequence>
</entry>
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    <accession>Q2H8L0</accession>
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        </recommendedName>
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                <person name="Untereiner W.A."/>
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        </source>
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    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Acyl_transf_3"/>
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    </dbReference>
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            <end position="136"/>
        </location>
    </feature>
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            <end position="189"/>
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        </location>
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            <end position="287"/>
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            <end position="378"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ91509.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="496" mass="56133" checksum="FDC9E6CA27F8333C" modified="2006-03-21" version="1">MPSDLEGTIEPKRDDELLGSGPPSSDMVAIASWLASSGSSGLIRVLSPWSSKPAGSQPEKLRPTAYLDGLRGFAAFLVYWHHHELWAHVPPQLASLEASFGFKGNHYFVTLPIIRNFFHGGHFAVASFFVISGYVLSAKPISLIHAGEQAKLADNIASALFRRWLRLYIPILCTTFIYMTFVHAFGIWIDGLSAKGNYLQAAWDWYAEIKNFSFVFNNGPIGWLSYNFHLWSIPVEFKGSIVIYTSLLAFSKCSRNARLWCEAGLIFYFMYIVDGWYCALFSAGMMLNDLDHLAAKDDLPAFFDRFRPHKTTIFYTLFAVSLYLGGCPANGSGAEDLARNPGWYLLSFLKPQAVSDVKWFFLFWAAMFLVISTPHISWLKRFFETRFCQYLGRISFSLYLVHGPVLWTLGDRLYAAVGWPKDSRFLNIPQWINLFPLPKSGPLGLEVAFLVPHLILLPVTFYLAEVVTRAFDEPSVRFPQWLYKTTSASRPARLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H984</accession>
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                <person name="Untereiner W.A."/>
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            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="507"/>
            <end position="555"/>
        </location>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
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        </location>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ91285.1"/>
        </source>
    </evidence>
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    </evidence>
    <sequence length="655" mass="71223" checksum="084F003A09A15A2E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9A0</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">CHGG_03204</name>
    </gene>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03204"/>
    <dbReference type="HOGENOM" id="CLU_2249819_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9A0"/>
    <dbReference type="Proteomes" id="UP000001056">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ91269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="104" mass="11145" checksum="50EBA3CA3EF31CB4" modified="2006-03-21" version="1">MARQRHSFLEWGWSPHIQGDTSVKLPIRLGVGPMPQPVDLLLLGSGQLWLLTPRGLSQSVGKPSTSASEASEIKAPIRIPCNETRRAALATALRRRVGALGGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9J5</accession>
    <name>Q2H9J5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ91174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001229624.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="4388690"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03109"/>
    <dbReference type="eggNOG" id="ENOG502RYYT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004392_0_0_1"/>
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    <dbReference type="OrthoDB" id="74412at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11282">
        <property type="entry name" value="ADF_coactosin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Severin"/>
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    </dbReference>
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        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="813"/>
        </location>
    </feature>
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        <location>
            <begin position="831"/>
            <end position="1168"/>
        </location>
    </feature>
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        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
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        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
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        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
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        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
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        <location>
            <begin position="521"/>
            <end position="534"/>
        </location>
    </feature>
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        <location>
            <begin position="632"/>
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        </location>
    </feature>
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        <location>
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        <location>
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            <end position="1018"/>
        </location>
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        <location>
            <begin position="1045"/>
            <end position="1059"/>
        </location>
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        <location>
            <begin position="1060"/>
            <end position="1090"/>
        </location>
    </feature>
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        <location>
            <begin position="1093"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1147"/>
            <end position="1164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1311" mass="140491" checksum="E188B84F4FAA1C50" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HA06</accession>
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        </submittedName>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000001056">
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="202"/>
        </location>
    </feature>
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        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="202" mass="20841" checksum="A35FF9CE066AC1CD" modified="2006-03-21" version="1">MLDASPAILPDPAIGARLCFCLLYADARSARTDGLRPRYVSKVLGTVVLGRGGSGAGPDEGVPDDEPDDADLTLAEARFITGDFISCAILPPDELTGDVAPATSARMGRGAGVGEARGGGHVGAPLPFAGPSRQRDYAAPGGYSGGGRGSRSGGSRGGYGGGGRFREREEPFGRGGFRMPEGEWRRGDRLPDGPPDNGRWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAG6</accession>
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        <recommendedName>
            <fullName evidence="4">Fe2OG dioxygenase domain-containing protein</fullName>
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        <name evidence="5" type="ORF">CHGG_02788</name>
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
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    </dbReference>
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    <dbReference type="GeneID" id="4389080"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02788"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_4_0_1"/>
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    <dbReference type="OMA" id="TYIRNSH"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="191"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ90853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="377" mass="41071" checksum="4313FA6CAED67131" modified="2006-03-21" version="1">MNSPFDDIPPFPEGLPLAPIAIISHAKLLDGDNDEAVRLLTAAKTHGFLYLNLQDTPQGKAFLAEADQLHAVAKEAFALPLHEKLPHALERGVSLFGYKAAGTVKTTDRDQRRDTTEFFCVSKDYVHNIARENIRGTPITYPPEITTHTPLFQSFTRRGHDCGLLVLRTLASQLGLPADSFDHLNRFDQPSGDHCRLTHKPPSPPNPDGSVSSSTLGLPSHTDFGSVTVLFNWLGGLQVESHIDTANTATTDGREGGGGGEREVVQREWQWVKPLPGHAIVNLGDAMVTFTNGALKSAKHRVVPSPGEQAGADRYSVVYFVRPHNDVPMRALAQFDDRTKAGALQVAGKFSADLARKGEVVLTAGEWMRQRGIQLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAG8</accession>
    <name>Q2HAG8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_02786</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229302.1">
        <property type="nucleotide sequence ID" value="XM_001229301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAG8"/>
    <dbReference type="FunCoup" id="Q2HAG8">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HAG8"/>
    <dbReference type="GeneID" id="4389078"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02786"/>
    <dbReference type="eggNOG" id="KOG0037">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051357_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HAG8"/>
    <dbReference type="OMA" id="YNKSYNP"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="EFh_PEF_Group_I"/>
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        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="176"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="212"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ90851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="278" mass="31608" checksum="E4AB035DFCF1EF5C" modified="2006-03-21" version="1">MAYNRPYNPDELPRFAEPEQKGNPRSPASAQPQSSRYENKPPPPRPAEHRGSGDPYSSHQGRLSPRQTAPPDRFGMSPPPSAGGGRPLHHNLPPANSRPPPSPAPRDSTADPTLLPLFRAVDKDGTGQLSERELSAALVNGDWTAFDPQTVRMMIRMFDSDRSGTIGFEEFCGLWSFLASWRSLFDRFDADRSGNISLDEFNNALVAFRYRLSERFVEILFRTYDKRNEGVMSFDLFVQACISLKRMTDVFKRYDDDRDGYITLSFEDFLIEILRQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAJ7</accession>
    <name>Q2HAJ7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_02757</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001229272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAJ7"/>
    <dbReference type="GeneID" id="4388664"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02757"/>
    <dbReference type="eggNOG" id="ENOG502QVC1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011017_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HAJ7"/>
    <dbReference type="OMA" id="ISVAHCQ"/>
    <dbReference type="OrthoDB" id="5600212at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TF_fung"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF10">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="625"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="655"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="684"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="696"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="714"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="747"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="777"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ90822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="874" mass="94927" checksum="D9A4C80B853DC7A8" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAS1</accession>
    <name>Q2HAS1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_02683</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229199.1">
        <property type="nucleotide sequence ID" value="XM_001229198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAS1"/>
    <dbReference type="FunCoup" id="Q2HAS1">
        <property type="interactions" value="976"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HAS1"/>
    <dbReference type="GeneID" id="4389109"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02683"/>
    <dbReference type="eggNOG" id="KOG0166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018084_6_0_1"/>
    <dbReference type="InParanoid" id="Q2HAS1"/>
    <dbReference type="OMA" id="EMIQMLY"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.690:FF:000003">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000021">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="10">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="124"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="333"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ90748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="547" mass="59980" checksum="D680D38145CB8B02" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HB13</accession>
    <name>Q2HB13_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229107.1">
        <property type="nucleotide sequence ID" value="XM_001229106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HB13"/>
    <dbReference type="GeneID" id="4389855"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02591"/>
    <dbReference type="eggNOG" id="ENOG502RJ2Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028829_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HB13"/>
    <dbReference type="OMA" id="GIWTFQH"/>
    <dbReference type="OrthoDB" id="5421971at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="370" mass="41257" checksum="55EB5E2B495F3E28" modified="2006-03-21" version="1">MAFIQDPRLRQTWNQFSHTTEAVTSDAAAGIWTFGHRYINPCLASLAGAVDSCTAVCLGDRDERARRARERDRGARGSRRSVGGGVAPEYSFDFYDDWEEDFADEFEVGVGGGEDVGRGGGGDEESPRRQPGKRPRSDTTNSGDTSSSYRSRGDLFPSDGEGDEDAVPLDDEFTVALERVDDRGSTKTRSSKGKRPADRDRDRDRDRGLSRTVSRTTLSSTNTPDESKWDSNPVSPVQEVEPVERVPSLEDLRREEEQAAKEEYEEIERRRRAAAQLAMQKGLGKEDAETRNKFDEAADDTPNNQPRHTPAEDLAPNGRRDTMEDDELEKFKFKAPQTAIREPSPIPTKEANAKLQSENTFVPARLPHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBJ4</accession>
    <name>Q2HBJ4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228926.1">
        <property type="nucleotide sequence ID" value="XM_001228925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBJ4"/>
    <dbReference type="STRING" id="306901.Q2HBJ4"/>
    <dbReference type="GeneID" id="4389823"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02410"/>
    <dbReference type="eggNOG" id="KOG1337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010578_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HBJ4"/>
    <dbReference type="OMA" id="WDIFCTL"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19180">
        <property type="entry name" value="SET_SpSET10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044432">
        <property type="entry name" value="Set10/Efm1_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF146">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="49079" checksum="049019FF7A66798A" modified="2006-03-21" version="1">MKPSEQARFDTLLEWSEKHGGKLHPSLEIYNDNVTKYSLRVKPSTGDALQPGFRAVTCPATTTLSYLNALIDGPIKLTDNAATNPTDSPPSPRTGAFPPSFTQSVPPHVLGRFFLIKEYLKGKDSFWWPYLATLPSPDQVNAWVLPAFWPEDDIAYLECTNAHVAIQEIQANVKGEFKQARKILKNENFPDVAAYTSLMYKWAFTIFTSRSFRPSLILSDTTKRHISTLLPQSVELDDFSILQPLLDIANHSPTAVYSWDTTSPADACTLVCGDRYPPGAQVFNNYGLKTNSELLLGYGFILPPTPSLHNDYVHLRKTQQRPPSSDPTITHNPHLPQTFLVSLRPVTHPSSAAVYRARPTLNPTPLRRPIPDGGDNNDGGRHHHHQQQWKSSAAPLLRALRARTADRPSHDASDARAAADDGAVAARSGGRGGRLGWVWKWK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-03" modified="2025-02-05" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBQ2</accession>
    <name>EIF3E_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Eukaryotic translation initiation factor 3 subunit E</fullName>
            <shortName evidence="1">eIF3e</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">INT6</name>
        <name type="ORF">CHGG_02352</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-3 subunit E family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228868.1">
        <property type="nucleotide sequence ID" value="XM_001228867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBQ2"/>
    <dbReference type="SMR" id="Q2HBQ2"/>
    <dbReference type="STRING" id="306901.Q2HBQ2"/>
    <dbReference type="GeneID" id="4389053"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02352"/>
    <dbReference type="eggNOG" id="KOG2758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031132_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HBQ2"/>
    <dbReference type="OMA" id="NCPWILR"/>
    <dbReference type="OrthoDB" id="417252at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21378">
        <property type="entry name" value="eIF3E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03004">
        <property type="entry name" value="eIF3e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019010">
        <property type="entry name" value="eIF3e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09440">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21357">
        <property type="entry name" value="EIF3E_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016255">
        <property type="entry name" value="eIF3e_su6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01186">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000365984" description="Eukaryotic translation initiation factor 3 subunit E">
        <location>
            <begin position="1"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="253"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01185"/>
        </source>
    </evidence>
    <sequence length="447" mass="51011" checksum="A0369C7656CB77E3" modified="2006-03-21" version="1">MASAPNANGDAAVSDYDLMLKLAQNLDRHMIFPLLEFSAGQLVDEESGVVRDEAKAREITQAKYSLLKNSNMTDYVANLYCELAGVEEPPAEFADKKQKVFSQLQNLEQQTSKIIELLEREDVVNNLRSDKVANLEFLKREHQVTMDMVNALFDLGNLQYSCGNYGDASEMLYRFRVLSTDNDKVAFATWGRLACEILTMNWESAMEELVKVRETIDTKLSQNPLAQLQHRTALTHWALFPLFNFEKAREPILELFFNAGYINTIQANCPWILRYLAVAVITNRGRAKNPGIHQKQMKDVVRIVKQEAYEYQDPITRFVHALAIDFDFEEAQRQLVLAEEVLRSDFFLLAHADDFVDSARHLIFESYCKIHARISLKDLSARLGLNADAAEKWIVNLIRDTRLDAKIDYKEGTVVMNHPPSSVYQQVIEKTKGGFFRTQVLTAAIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCA0</accession>
    <name>Q2HCA0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Concentrative nucleoside transporter C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_02154</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228670.1">
        <property type="nucleotide sequence ID" value="XM_001228669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCA0"/>
    <dbReference type="STRING" id="306901.Q2HCA0"/>
    <dbReference type="GeneID" id="4389332"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02154"/>
    <dbReference type="eggNOG" id="KOG3747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016813_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HCA0"/>
    <dbReference type="OMA" id="IVWHTVI"/>
    <dbReference type="OrthoDB" id="6075923at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="551"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="588"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter N-terminal" evidence="9">
        <location>
            <begin position="208"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside transporter/FeoB GTPase Gate" evidence="11">
        <location>
            <begin position="290"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="10">
        <location>
            <begin position="393"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ90219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="615" mass="67201" checksum="95D4B7F8FC13F89A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCK6</accession>
    <name>Q2HCK6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_02048</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221269.1">
        <property type="nucleotide sequence ID" value="XM_001221268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCK6"/>
    <dbReference type="STRING" id="306901.Q2HCK6"/>
    <dbReference type="GeneID" id="4386969"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02048"/>
    <dbReference type="eggNOG" id="KOG2294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_419183_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCK6"/>
    <dbReference type="OMA" id="MDDITIC"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045912">
        <property type="entry name" value="FOXJ2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078:SF2">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078">
        <property type="entry name" value="FORKHEAD BOX PROTEIN J2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="7">
        <location>
            <begin position="252"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="5">
        <location>
            <begin position="252"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="71"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="128"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="217"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="350"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="497"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ93813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="654" mass="70881" checksum="A05C53C4CDB718C1" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCL2</accession>
    <name>Q2HCL2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221263.1">
        <property type="nucleotide sequence ID" value="XM_001221262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCL2"/>
    <dbReference type="STRING" id="306901.Q2HCL2"/>
    <dbReference type="GeneID" id="4387667"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02042"/>
    <dbReference type="eggNOG" id="ENOG502RG10">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_921646_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCL2"/>
    <dbReference type="OMA" id="WHAIDSG"/>
    <dbReference type="OrthoDB" id="3364132at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR EAF N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="1">
        <location>
            <begin position="9"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="302" mass="34236" checksum="391E10BB56A6EDED" modified="2006-03-21" version="1">MAIITSFPGLSVTVEVEGKAASEFHHPIRECGASTKLEREDFDLPPDHKGRLPHVVRYIEGTPGEKFEVVIVKEPNFPERGHHLGYKLYIDGKEAGKDQHHPGYPASQWTSRVSGFISGNPTNGYREHSFRFKDLQLTDENISDEDLRRQTSLAADYGRLIVYVYNMNESGWKHSCRTYDETPEIRDPKFSEQALKGSMLDCVVIETSHPIDPPAPEKCREWNHSDPAKLPFAVFEFIYRTRTLLSAMTPQPDTKHSASENNLHNTCGTAGERGSGPMPAVELRQRYKVHRAGDGRETYERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCN1</accession>
    <name>Q2HCN1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_02023</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221244.1">
        <property type="nucleotide sequence ID" value="XM_001221243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCN1"/>
    <dbReference type="STRING" id="306901.Q2HCN1"/>
    <dbReference type="GeneID" id="4388123"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02023"/>
    <dbReference type="eggNOG" id="KOG0498">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006113_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCN1"/>
    <dbReference type="OMA" id="RMKSVWD"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005221">
        <property type="term" value="F:intracellularly cyclic nucleotide-activated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000057">
        <property type="entry name" value="Cyclic nucleotide-binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF24">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G03170)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16643">
        <property type="entry name" value="cNMPbd_u2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="80"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="284"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="539"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="202"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="407"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="712"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="960"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="968"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ93788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1141" mass="124639" checksum="6EE310FD8D88EA13" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDV1</accession>
    <name>Q2HDV1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_01603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220824.1">
        <property type="nucleotide sequence ID" value="XM_001220823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDV1"/>
    <dbReference type="GeneID" id="4386427"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01603"/>
    <dbReference type="HOGENOM" id="CLU_2014985_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HDV1"/>
    <dbReference type="OrthoDB" id="4587245at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ93368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="123" mass="14316" checksum="9DD65D3FD6034543" modified="2006-03-21" version="1">MNALERQDLQLLLEKDLGHAWWYCHCCSLLLPISTQGPTGGTRDGLSWVAGWDFNRPYHNRHWLEGSSFSVDYQSVRLVMNRHFFGPLKGQMAAALVRKMVHPNCTRRAFSLSYPDPKWRRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HE40</accession>
    <name>Q2HE40_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_01514</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220735.1">
        <property type="nucleotide sequence ID" value="XM_001220734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HE40"/>
    <dbReference type="STRING" id="306901.Q2HE40"/>
    <dbReference type="GeneID" id="4388163"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01514"/>
    <dbReference type="eggNOG" id="KOG2399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1250524_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HE40"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209158" description="Sodium/calcium exchanger membrane region domain-containing protein" evidence="9">
        <location>
            <begin position="19"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="34"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ93279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="221" mass="23241" checksum="1BEDD4F7F8FC90B6" modified="2006-03-21" version="1">MLLYTLLTSLILLAALLATTTPHKKPRYHFLLCFLGFIISVAWISTIAGEVVGVLKALGVILGISEAILGLTVFAVGNSLGDLVADVTVARLGYPVMALAASVGGPMLNILLGVGIGGAWMGISKAKKHQRKHPGRSGYAAALPCCMAYAAGQSRHGTYITLAGGLSRTGEVRIAGIRTRPPSPLAFHQPIPHSTMKGTRGQRPPHSIRLCDAPRLGFSWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HE49</accession>
    <name>Q2HE49_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucanase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_01505</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220726.1">
        <property type="nucleotide sequence ID" value="XM_001220725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HE49"/>
    <dbReference type="STRING" id="306901.Q2HE49"/>
    <dbReference type="GeneID" id="4388194"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01505"/>
    <dbReference type="eggNOG" id="ENOG502QPHV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020817_3_2_1"/>
    <dbReference type="InParanoid" id="Q2HE49"/>
    <dbReference type="OMA" id="DDHEANM"/>
    <dbReference type="OrthoDB" id="412382at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.100.10:FF:000001">
        <property type="entry name" value="Glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209243" description="Glucanase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ93270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="452" mass="49003" checksum="98EB36F1109730A6" modified="2006-03-21" version="1">MYRQVATALSFASLVLGQQVGTLTAETHPSLPIEVCTAPGSCTKEDTTVVLDANWRWTHVTDGYTNCYTGNAWNETACPDGKTCAANCAIDGAEYEKTYGITTPEEGALRLNFVTESNVGSRVYLMAGEDKYRLFNLLNKEFTMDVDVSNLPCGLNGAVYFSEMDEDGGMSRFEGNKAGAKYGTGYCDSQCPRDIKFINGEANSEGWGGEDGNSGTGKYGTCCAEMDIWEANLDATAYTPHPCKVTEQTRCEDDTECGAGDARYEGLCDRDGCDFNSFRLGNKEFYGPEKTVDTSKPFTLVTQFVTADGTDTGALQSIRRFYVQDGTVIPNSETVVEGVDPTNEITDDFCAQQKTAFGDNNHFKTIGGLPAMGKSLEKMVLVLSIWDDHAVYMNWLDSNYPTDADPTKPGVARGRCDPEAGVPETVEAAHPDAYVIYSNIKIGALNSTFAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEB2</accession>
    <name>Q2HEB2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Amino-acid transporter arg-13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_01442</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220663.1">
        <property type="nucleotide sequence ID" value="XM_001220662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEB2"/>
    <dbReference type="FunCoup" id="Q2HEB2">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HEB2"/>
    <dbReference type="GeneID" id="4387029"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01442"/>
    <dbReference type="eggNOG" id="KOG0758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_16_3_1"/>
    <dbReference type="InParanoid" id="Q2HEB2"/>
    <dbReference type="OMA" id="PIDCFRQ"/>
    <dbReference type="OrthoDB" id="2139348at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000109">
        <property type="entry name" value="Ornithine carrier protein AmcA/Ort1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF31">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="33"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="134"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="251"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ93207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="37726" checksum="25C7D0D27F135D98" modified="2006-03-21" version="1">MEPATNQEGASDLKPFSETTTTSAHLKPRTAVMEAIEDIIYGSVAVIVGKYIEYPFDTVKVRLQSQPDHLPLQYRGPLDCFRQSIRADGFLGLYRGISAPLVGAALENSSLFFWERLGRAAVYAAGYTPRDQALPLSALWATGAFSGAMTSFVLTPVELVKCKIQVPASASEGGSKAPPPLRPLPVIRDIWRHQGLRGFWHGQLGTLIRESGGCAAWFGSKETVTKLMREWNERSARSEAERERVRAADALPLWQQAVAGASAGMMYNFLFFPADTVKSRMQTTPIGEGAAPQRSFSGETAALWKQAGLKGFYRGCGITVLRSVPSSAFIFMVYDGLKKYFPMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEH7</accession>
    <name>Q2HEH7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_01377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220598.1">
        <property type="nucleotide sequence ID" value="XM_001220597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEH7"/>
    <dbReference type="GeneID" id="4387395"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01377"/>
    <dbReference type="HOGENOM" id="CLU_2263440_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HEH7"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ93142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="103" mass="11460" checksum="4E7399F4BF463498" modified="2006-03-21" version="1">MAFEALNPHLCIPALRAPAVSVRFSSPRVRTGNFFGHNNGDVDNMVRHICSVHQQSPMAKAQAERPILKPLGVGPRTFRSYSFRPAFTTGPWVIWKAYPGILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HF75</accession>
    <name>Q2HF75_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 16">Pyruvate carboxylase</fullName>
            <ecNumber evidence="5 16">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">CHGG_01129</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>hydrogencarbonate + pyruvate + ATP = oxaloacetate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="5 16"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220350.1">
        <property type="nucleotide sequence ID" value="XM_001220349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HF75"/>
    <dbReference type="SMR" id="Q2HF75"/>
    <dbReference type="FunCoup" id="Q2HF75">
        <property type="interactions" value="608"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HF75"/>
    <dbReference type="GeneID" id="4387604"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01129"/>
    <dbReference type="eggNOG" id="KOG0369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HF75"/>
    <dbReference type="OMA" id="AEACICY"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07937">
        <property type="entry name" value="DRE_TIM_PC_TC_5S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000018">
        <property type="entry name" value="Biotin carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.600.10:FF:000002">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000033">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.600.10">
        <property type="entry name" value="pyruvate carboxylase f1077a mutant domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055268">
        <property type="entry name" value="PCB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006761">
        <property type="entry name" value="PRK09282.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778">
        <property type="entry name" value="PYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778:SF2">
        <property type="entry name" value="PYRUVATE CARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001594">
        <property type="entry name" value="Pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 16" id="KW-0092">Biotin</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="8 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="23">
        <location>
            <begin position="1"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="22">
        <location>
            <begin position="47"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="24">
        <location>
            <begin position="536"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="21">
        <location>
            <begin position="1074"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="319"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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            <position position="127"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
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        <ligand>
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            <position position="878"/>
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            <name>substrate</name>
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            <position position="713"/>
        </location>
    </feature>
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            <position position="1115"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
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            <dbReference type="PROSITE" id="PS50991"/>
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</entry>
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                <person name="Untereiner W.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209459" description="Dystroglycan-type cadherin-like domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="980"/>
        </location>
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        <location>
            <begin position="450"/>
            <end position="473"/>
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    </feature>
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        <location>
            <begin position="24"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="4">
        <location>
            <begin position="127"/>
            <end position="241"/>
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        <location>
            <begin position="482"/>
            <end position="511"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="575"/>
        </location>
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    </feature>
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    </feature>
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            <begin position="648"/>
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            <end position="897"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="957"/>
            <end position="972"/>
        </location>
    </feature>
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        <source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00736"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ92286.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="980" mass="104005" checksum="FD02F22D96A8ACDD" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGZ3</accession>
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        <submittedName>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Sordariomycetes</taxon>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
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    <dbReference type="AlphaFoldDB" id="Q2HGZ3"/>
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    <dbReference type="GeneID" id="4387806"/>
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    <dbReference type="HOGENOM" id="CLU_615380_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGZ3"/>
    <dbReference type="OrthoDB" id="7608935at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="445" mass="48657" checksum="ACEF91EEBBA93BB5" modified="2006-03-21" version="1">MANPTVSSGSKPLMTDSITGQAPSSRAHGGWNRGINSGLRTSFAGKDNLRKLARPKRLHDPSRNRLPSRWTSTVWLCPRQTPTSPGSAAAVHGRLGFAKCTAAMQAAKEARLDAEELQSMSLKALEVDIEEPWNDSPAKLGQSENAVSEQQSNDQSAGNTPASLGSQEANDWVFPPTPSCSDFEIGRKDQRAWEERFMAWCKSLIQLNECKIKPCRPGDKLQTSDAVSPPPKDSAPSPMTALSNGLDKESNDGSGWPAGARKMQNTARSISEDQSRRDFLPRGHYGPACGLNPQKTKEGVWEIWSQANCDRYQDQASSEMAIDFEASAGSASSERPDLGKSMVPKRHIFFEEADDDDEAEEFIRPPVQKNARTGHISFAGNRGDHSGRRPNKQYDDRNGRTGFAQPPLPPGPPPPFAATGLSSPNPEKWRSAKRGRSKILVRTWA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-08-21" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH37</accession>
    <name>H2A_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">HTA1</name>
        <name type="ORF">CHGG_00467</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text>The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location>Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The [ST]-Q motif constitutes a recognition sequence for kinases from the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated to form H2AS128ph (gamma-H2A) in response to DNA double-strand breaks (DSBs) generated by exogenous genotoxic agents and by stalled replication forks. Phosphorylation is dependent on the DNA damage checkpoint kinases MEC1/ATR and TEL1/ATM, spreads on either side of a detected DSB site and may mark the surrounding chromatin for recruitment of proteins required for DNA damage signaling and repair. Gamma-H2A is removed from the DNA prior to the strand invasion-primer extension step of the repair process and subsequently dephosphorylated. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Acetylated by ESA1 to form H2AK4ac and H2AK7ac.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">In contrast to vertebrates and insects, its C-terminus is not monoubiquitinated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H2AK4ac = acetylated Lys-6; H2AK7ac = acetylated Lys-10; H2AS128ph = phosphorylated Ser-131.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAQ92232" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92232.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219688.1">
        <property type="nucleotide sequence ID" value="XM_001219687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH37"/>
    <dbReference type="SMR" id="Q2HH37"/>
    <dbReference type="FunCoup" id="Q2HH37">
        <property type="interactions" value="859"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HH37"/>
    <dbReference type="GeneID" id="4388024"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08314"/>
    <dbReference type="HOGENOM" id="CLU_062828_7_3_1"/>
    <dbReference type="InParanoid" id="Q2HH37"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000008">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-0544">Nucleosome core</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000297732" description="Histone H2A">
        <location>
            <begin position="2"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="[ST]-Q motif">
        <location>
            <begin position="131"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="site" description="Not ubiquitinated" evidence="3">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="6"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="1">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="134" mass="14183" checksum="EE093088E6ADB0F8" modified="2007-08-21" version="2">MTGGGKSGGKASGSKNAQSRSSKAGLAFPVGRVHRLLRKGNYAQRVGAGAPVYLAAVLEYLAAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGHVTIAQGGVLPNIHQNLLPKKTGKTGKTLSQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHN9</accession>
    <name>Q2HHN9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_00265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219486.1">
        <property type="nucleotide sequence ID" value="XM_001219485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHN9"/>
    <dbReference type="SMR" id="Q2HHN9"/>
    <dbReference type="GeneID" id="4387592"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00265"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="InParanoid" id="Q2HHN9"/>
    <dbReference type="OMA" id="KQPNDPV"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ92030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="297" mass="31731" checksum="DEDFAB0E9E57D001" modified="2006-03-21" version="1">MAPLVWLITGCSSGFGAQFVHSALARGDKVIATGRNAATKLKQFEGTGAAIVDLDVSLPEAEVKKIIDEAVKIYGRIDVLVNNAGYGLNEDYQKLFNVNFFGALSVTRAVLPYMRAQQSGTIAFVGSMYAWWAPTMVSVYGAAKGALKAIVDGLAAELAPFNIRTIDFEPGFFHTQLTDLSKLLENASTAPPLDDYAGHRAAMANVAGAMAGNERGDVKKGVELMVDVIRGEGRASGKKIPPRLPIGDDAVRVVEGTCRNMLKIIDEWRGDVAGTTDRDEFKGEVPGIEAIVTVPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHX0</accession>
    <name>Q2HHX0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_00184</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219405.1">
        <property type="nucleotide sequence ID" value="XM_001219404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHX0"/>
    <dbReference type="GeneID" id="4386622"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00184"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_23_6_1"/>
    <dbReference type="InParanoid" id="Q2HHX0"/>
    <dbReference type="OMA" id="HETTEKC"/>
    <dbReference type="OrthoDB" id="4842715at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="4">
        <location>
            <begin position="86"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="462"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ91949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="498" mass="54115" checksum="D8851BD72668D636" modified="2006-03-21" version="1">MTRRPGLAERFFPDPPANLADVEDQAFLGSWNPGFDVSPAVTPTEVAKAIGGSSPWKAPGEDLLPMGLLKACGTPLAEVLAVLATRCLDLGWFPNRFKRAKTVVLPKPGKAPPVYQTPGGYRPIALLPTLGKVVESVVARKVTQAAEVNGLLPDEQTGNRAHNSTELAVRLVVAQVQEAWRQKAAASLLQLEISGAFDTVNHTRLLATLREMGYPRWLILWKKDWLTGREATLLLDSKTAVPTAIRAGVPQGSPLSPVLFILYISSLYKQLQDEHPHLAITWFADDTNLLVFGRNPEANVRQLEAAGRHQPRQTEGVYQVPVEKKLRTQSYALSRLTASTWGLGPAKAREVYTKCIRSALAYGASSFHIPTDVGGEPVKKGITKALGKAQNKSLRIVAGAFKSTPIRNLETETWVPPLDLYLNKRLADFENRLQQPDLDDGQGGKTAGSVVLTACRMIQQRLSSRRGNRQPTANLGTSRAYGGGESCGHGHALDGGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHX9</accession>
    <name>Q2HHX9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219396.1">
        <property type="nucleotide sequence ID" value="XM_001219395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHX9"/>
    <dbReference type="GeneID" id="4387611"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00175"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006029_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HHX9"/>
    <dbReference type="OMA" id="EYPHRRR"/>
    <dbReference type="OrthoDB" id="5095644at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718">
        <property type="entry name" value="OS01G0519700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718:SF3">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="2">
        <location>
            <begin position="276"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="593"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="636"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="727"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="818" mass="90882" checksum="090537074124E558" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HIA2</accession>
    <name>Q2HIA2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_00052</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="2">Binds 2 manganese ions per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219273.1">
        <property type="nucleotide sequence ID" value="XM_001219272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HIA2"/>
    <dbReference type="STRING" id="306901.Q2HIA2"/>
    <dbReference type="GeneID" id="4386571"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00052"/>
    <dbReference type="eggNOG" id="ENOG502RJG4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030515_2_1_1"/>
    <dbReference type="InParanoid" id="Q2HIA2"/>
    <dbReference type="OMA" id="DWITHTR"/>
    <dbReference type="OrthoDB" id="10263073at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF9">
        <property type="entry name" value="SLL1358 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208992" description="Cupin type-1 domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="4">
        <location>
            <begin position="76"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="4">
        <location>
            <begin position="255"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ91817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="346" mass="37598" checksum="8403A0763B61684B" modified="2006-03-21" version="1">MKLALHLSALAAVNAVLGATLPGGKGGPQFEKGQPIAGNGKGAPLLGGTNRQVDISNPDNLGRQSTDNGIVPNLKWRFSDSKTRLFKGGWLREQVIQDLPQSHDISAAQQHLSKGAIRELHWHRVAEWGFVYAGSVLISAVDEFGKYQVETLNFGDIWYFPKGVAHTVQGLGEENEFLLVFDDADFDKVGTTFNIDDWVAHTPRDIVAKNFGLDPSIFDHVPTPNPNIFNGTVSTKNVTGDPGDVLTGDASFVYRTLQHEPEPVPGKGGQFYKIDSTNFPASKTLAATFVTLKPGGLRELHWHPNAEEWLYFHKGTARATVFIGNAASRTFDFSAGDTAAFPDNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GML0</accession>
    <name>Q2GML0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ82976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226061.1">
        <property type="nucleotide sequence ID" value="XM_001226060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GML0"/>
    <dbReference type="STRING" id="306901.Q2GML0"/>
    <dbReference type="GeneID" id="4397175"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10794"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_23_5_1"/>
    <dbReference type="InParanoid" id="Q2GML0"/>
    <dbReference type="OMA" id="CNEDMEI"/>
    <dbReference type="OrthoDB" id="5243754at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ82976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="508" mass="56762" checksum="6F7A8AC8E67B9495" modified="2006-03-21" version="1">MYRGGTKWEGQAAARWTSPGGVHPSPKASIKASRWDKRAWAFWERLLSKRCLILTGRRVFFQWRSTAPRHVRGHPRLMLARSTLCNEDMEIVKLAVVEAEASIYPVRERHAQAAASLWINIHTLPGTHPLAMKKVRTTVRFVSPLQKIARVAEGVRVDRMETIQEYAVPPWVPRLRPTLEADRGKAVYMVNKISGIVIATSSSVKKGIVGMGGLARDILFNRTSETVTNYAVVLGTREEQNPYTAELAAIAMALEKLPASICHRHITVITRNQSALAAVGQPRQQSGQSIIRQIYDLARLHRQRGNSVNFLWIPAEIDFALGSDAKAAAQRASKQGRTPDSQIPQAKSTAMRLAMERQRATRVLPVSVGKFSKAMDAALPGKHTRHLYDKLKRREACVLAQLRTGMARLNGFLSRIGAVESDLCACGQARESVEHFLFRCVRWTALREDMLQCTVARRGSLSFYLGGKAPSDTRHWSPDMKAVRATIKYAMATGRLELNEEESLDQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN14</accession>
    <name>Q2GN14_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Microbial-type PARG catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228567.1">
        <property type="nucleotide sequence ID" value="XM_001228566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN14"/>
    <dbReference type="GeneID" id="4396025"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10640"/>
    <dbReference type="eggNOG" id="ENOG502S35J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_758624_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GN14"/>
    <dbReference type="OrthoDB" id="9985428at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596">
        <property type="entry name" value="DUF2263 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596:SF1">
        <property type="entry name" value="MICROBIAL-TYPE PARG CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="39805" checksum="D293923CB0E40220" modified="2006-03-21" version="1">MEERGAASLPLEYCAGSVALSSTAEGANYNCYPSSPVGKEFYPLTTRQDFQKLGIRPVALPLYLPQHCRQDDKPSSASSSRPRTPPRRVPARRTSPYITRTTMGESGSGSGLGNGRGQASALPGFQQTSTGTFNSPPNSREALREVARETQEVIGRILEQLSTTEKAESSSQYNLDTLRRLNPFFCPAFSTPTKIQVLNEDTLNAGLALLPSTTNQDPSTTTRAPCSAAATGCSPASGRSRRRPPSSASSASSALRNPRTQTFRLAGGARKTVFQSDTDRDLTKRNMRLVLRIAAHHRHRHLVLGALGCGVYANPPEDVAHCWLEVLREDEFSGGWWQQICFAVFDPSGTGNYEVFMRVLHDQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNN6</accession>
    <name>Q2GNN6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial dicarboxylate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_10418</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228345.1">
        <property type="nucleotide sequence ID" value="XM_001228344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNN6"/>
    <dbReference type="FunCoup" id="Q2GNN6">
        <property type="interactions" value="796"/>
    </dbReference>
    <dbReference type="GeneID" id="4396460"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10418"/>
    <dbReference type="eggNOG" id="KOG0759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1294251_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNN6"/>
    <dbReference type="OMA" id="YMNAKPG"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="49"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="144"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="14"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ84014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="22706" checksum="A9DD7C5C865835C3" modified="2006-03-21" version="1">MPKSMSGTFVHIVKHNGIRGPLQRPVEPPSSGKSPTPPHAQAPLATPPDRHGHPPRASSAASPGNAADVLNVRMQHDAALPAGQRRNYAHAGDGLVRMVREEGAASLFRGVWPNSARAAAMTASQLASYDVFKRTMLRLTPMQDNLATHFSASFLAGVVAATVTSPIDVIKTRVMSATGGDVGVVGVLREVYAKEGMRWMFKGWVPSFLRLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNP5</accession>
    <name>Q2GNP5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rgp1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228336.1">
        <property type="nucleotide sequence ID" value="XM_001228335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNP5"/>
    <dbReference type="STRING" id="306901.Q2GNP5"/>
    <dbReference type="GeneID" id="4396142"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10409"/>
    <dbReference type="eggNOG" id="KOG4469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005862_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNP5"/>
    <dbReference type="OMA" id="VLGHDLM"/>
    <dbReference type="OrthoDB" id="1918at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014848">
        <property type="entry name" value="Rgp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12507">
        <property type="entry name" value="REDUCED GROWTH PHENOTYPE 1 RGP1, YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08737">
        <property type="entry name" value="Rgp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="542"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="836" mass="88342" checksum="9719BFBD0EABCFFD" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNZ2</accession>
    <name>Q2GNZ2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_10312</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228239.1">
        <property type="nucleotide sequence ID" value="XM_001228238.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2GNZ2">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GNZ2"/>
    <dbReference type="GeneID" id="4396195"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10312"/>
    <dbReference type="eggNOG" id="KOG1064">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001351_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNZ2"/>
    <dbReference type="OMA" id="TIRTHRG"/>
    <dbReference type="OrthoDB" id="342131at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059065">
        <property type="entry name" value="Ig_Tag1-like_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059066">
        <property type="entry name" value="Ig_Tag1-like_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055011">
        <property type="entry name" value="Tag1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26174">
        <property type="entry name" value="LEA-2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26150">
        <property type="entry name" value="LEA-2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26153">
        <property type="entry name" value="LEA-2L_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22786">
        <property type="entry name" value="Tag1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1 C-terminal" evidence="4">
        <location>
            <begin position="471"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1-like fourth Ig-like" evidence="5">
        <location>
            <begin position="595"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1-like fifth Ig-like" evidence="6">
        <location>
            <begin position="743"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="3">
        <location>
            <begin position="1434"/>
            <end position="2096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2133"/>
            <end position="2182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ83908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="2182" mass="240782" checksum="843A00BE843E66E3" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPV7</accession>
    <name>Q2GPV7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Alpha-glucuronidase</fullName>
            <ecNumber evidence="2 9">3.2.1.139</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">aguA</name>
        <name evidence="14" type="ORF">CHGG_09997</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Alpha-glucuronidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Releases 4-O-methylglucuronic acid from xylan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>an alpha-D-glucuronoside + H2O = D-glucuronate + an alcohol</text>
            <dbReference type="Rhea" id="RHEA:20005"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="ChEBI" id="CHEBI:58899"/>
            <dbReference type="EC" id="3.2.1.139"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the glycosyl hydrolase 67 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.139" evidence="2 9"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227924.1">
        <property type="nucleotide sequence ID" value="XM_001227923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPV7"/>
    <dbReference type="STRING" id="306901.Q2GPV7"/>
    <dbReference type="GeneID" id="4396104"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09997"/>
    <dbReference type="eggNOG" id="ENOG502QWS4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007125_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GPV7"/>
    <dbReference type="OMA" id="IWRAFVY"/>
    <dbReference type="OrthoDB" id="6501611at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046559">
        <property type="term" value="F:alpha-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02795">
        <property type="entry name" value="CBM6-CBM35-CBM36_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1330.10">
        <property type="entry name" value="Alpha-glucuronidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037054">
        <property type="entry name" value="A-glucoronidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005154">
        <property type="entry name" value="Glyco_hydro_67_aGlcAse_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011099">
        <property type="entry name" value="Glyco_hydro_67_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011100">
        <property type="entry name" value="Glyco_hydro_67_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39207">
        <property type="entry name" value="ALPHA-GLUCURONIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39207:SF1">
        <property type="entry name" value="ALPHA-GLUCURONIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07477">
        <property type="entry name" value="Glyco_hydro_67C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07488">
        <property type="entry name" value="Glyco_hydro_67M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03648">
        <property type="entry name" value="Glyco_hydro_67N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="Alpha glucuronidase N-terminal" evidence="11">
        <location>
            <begin position="94"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 67 catalytic" evidence="13">
        <location>
            <begin position="222"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 67 C-terminal" evidence="12">
        <location>
            <begin position="550"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ83593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="923" mass="101436" checksum="A9851AD0B296138D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQ66</accession>
    <name>Q2GQ66_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_09888</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
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    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227815.1">
        <property type="nucleotide sequence ID" value="XM_001227814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQ66"/>
    <dbReference type="GeneID" id="4396911"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09888"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_285440_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQ66"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF10">
        <property type="entry name" value="L-ORNITHINE N(5)-OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="587"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="643"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="643"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ83484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1085" mass="120643" checksum="D675101309AF80EF" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQM8</accession>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1517703_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQM8"/>
    <dbReference type="Proteomes" id="UP000001056">
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="177" mass="19321" checksum="52C59BB582D56C4C" modified="2006-03-21" version="1">MEKKTPPLLLPGSPHTLPAELPIIAPTGYMQGGIDRKAQSTAITAPQAIPSFGMSPETNPPAVGPAESGLREHGEPIVTHRVGTGWNLPLHPLAMIYTHHASSHAADVPSKQKNSAARWAMTSMVTSTLVLLERVTLVPTETSPSSRAQLDMERRFERAYNYRLILLTFIPHHNRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GR63</accession>
    <name>Q2GR63_CHAGB</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">CHGG_09541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ85527.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="306901.Q2GR63"/>
    <dbReference type="GeneID" id="4395183"/>
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    <dbReference type="HOGENOM" id="CLU_065008_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GR63"/>
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    <dbReference type="OrthoDB" id="5226655at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ85527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="251" mass="26807" checksum="05601997BD983A73" modified="2006-03-21" version="1">MTPGVSPMQQYQQPWGPASIVGGDYHSVSALSPNSDVPWHSFSGADDQQTYVGSEPPREKRICGLRKRVFIIIAVVLAVVIIAVAAGAGIASAMASRQSDSGAAPVETGSATESATESGSSPTSASSTEPTSVSTTSSAPTASPTFLNNQTDPSIFEMFAFQGFSGNDFTGDATEIYVEPGYYDLNISITSYVWATEKTDCCVTFCKDKQTTGGYKCDSIRRKATEDNESFPRVSLWCGNRLDKKQRVRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRC1</accession>
    <name>Q2GRC1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein RTA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_09483</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227410.1">
        <property type="nucleotide sequence ID" value="XM_001227409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRC1"/>
    <dbReference type="FunCoup" id="Q2GRC1">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="GeneID" id="4395148"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09483"/>
    <dbReference type="eggNOG" id="ENOG502QURG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_3_1_1"/>
    <dbReference type="InParanoid" id="Q2GRC1"/>
    <dbReference type="OMA" id="ITTIIFH"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF35">
        <property type="entry name" value="RTA1 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ85469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="36617" checksum="3E64F70F856C4DB2" modified="2006-03-21" version="1">MAGEPAFEGGFKLYRYDPNLAANIVFIVLFAGVSIGHAVLLFRRRTWSFIPFLIGCIFETIGYIGRAISAQENPDYSLNAYILQTLLILLGPALLAASIYMILGRLIRLLGAEEYALIRTKWMTKVFVTGDVLSFLAQGAGGGLMAVAKTKDDQKRGENVILAGLAIQIIFFGFFIITTILFHRRIAAHPTPRSYSVTGPWRQLLVALYISSVLVLVRSVFRMIEFGMGNDSVLMSNEGYLLGLDGALMLLVAAVLLWSHPSRALAGYKEVLASSGGESGRNTTESFQMLPVHPDVAPAGVAMPGKYDSDSTAVVGGQGSGYEVPARENRYSSTYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRJ7</accession>
    <name>Q2GRJ7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_09407</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227334.1">
        <property type="nucleotide sequence ID" value="XM_001227333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRJ7"/>
    <dbReference type="GeneID" id="4394904"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09407"/>
    <dbReference type="eggNOG" id="ENOG502SGDI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108580_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRJ7"/>
    <dbReference type="OMA" id="RIVRYQH"/>
    <dbReference type="OrthoDB" id="5299893at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001919">
        <property type="term" value="P:regulation of receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028209">
        <property type="entry name" value="LAMTOR1/MEH1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15454">
        <property type="entry name" value="LAMTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01262">
        <property type="entry name" value="LAMTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ85393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="17844" checksum="21A1F6BF24094533" modified="2006-03-21" version="1">MGNCSSCLGNRRRDEYDEEEDEARHLFDDPNNLNYNSFDQQHMMGQEDPQEVQREIEALQRVVARTSDAMVDIYEIVPQDKAAQTAPGPYVYVGQDATTVRYQTLLSKLSSHDDLPSVARVDWGTPDDDTIEMQQGVMPIKVEGGDSLVGNFADAAAAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRQ8</accession>
    <name>Q2GRQ8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CmcJ-like methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227273.1">
        <property type="nucleotide sequence ID" value="XM_001227272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRQ8"/>
    <dbReference type="GeneID" id="4395559"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09346"/>
    <dbReference type="eggNOG" id="ENOG502SRIH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042688_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GRQ8"/>
    <dbReference type="OMA" id="CDWTTID"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="33336" checksum="A0B1F87419608570" modified="2006-03-21" version="1">MAQTMTATVTTVPESKVHVPIPYLAKSPLYKTEKPYAAVFDVKDIPGAKATNHVIELMPQDVHNARDIPPGTFTLEKNGFEFLKRQNCLDVSNIDDEELIYNKFRVEMEDTLRKRFPQYRDIIYLDHSIRKRSPMFPGTPGQPVTFPQPAALPHFDFTTHGSFLRMALMYPGEPEVYQDRDFDLINIWKVLAGPNNDWPLAVCDAQSVDFTTDYVANDVINEITVGENGLMHYNSKHKWYFLKDQEVDDLIVFRNSNSLGKRAIAFHAAFDPKLVDGPPRQSIEMRFAGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRR5</accession>
    <name>Q2GRR5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CHGG_09339</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227266.1">
        <property type="nucleotide sequence ID" value="XM_001227265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRR5"/>
    <dbReference type="STRING" id="306901.Q2GRR5"/>
    <dbReference type="GeneID" id="4395683"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09339"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_295106_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRR5"/>
    <dbReference type="OMA" id="CAAGIAN"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208538" description="chitinase" evidence="14">
        <location>
            <begin position="25"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="15">
        <location>
            <begin position="286"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="15">
        <location>
            <begin position="350"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="16">
        <location>
            <begin position="493"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="947"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="947"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAQ85325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1026" mass="107309" checksum="D2BCC957DAC1D876" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRU6</accession>
    <name>Q2GRU6_CHAGB</name>
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        <recommendedName>
            <fullName evidence="3">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">CHGG_09308</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227235.1">
        <property type="nucleotide sequence ID" value="XM_001227234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRU6"/>
    <dbReference type="STRING" id="306901.Q2GRU6"/>
    <dbReference type="GeneID" id="4394849"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09308"/>
    <dbReference type="eggNOG" id="KOG2620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024949_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GRU6"/>
    <dbReference type="OMA" id="YLQMLPK"/>
    <dbReference type="OrthoDB" id="434619at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08829">
        <property type="entry name" value="SPFH_paraslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF10">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
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        <property type="entry name" value="PHB"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="77"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ85294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="309" mass="33388" checksum="2303B2436AEB7A13" modified="2006-03-21" version="1">MSLTTAQRALVPTVRASLSTSTRSSRTLPFAALALSNIAASRRAFNTTQRNALPSGMGGGLIPPTYFQKPASLPMNTVVRFVPQQTAWIVERMGKFNRILQPGLAILIPFLDRIAYVKSLKEVAIEIPSQSAITADNVTLELDGVLYTRVFDAYKASYGVEDAEYAISQLAQTTMRSEIGQLTLDHVLKERAALNTNITQAINEAAQAWGVTCLRYEIRDIHAPKPVVDAMHRQVTAERSKRAEILDSEGQRQSAINIAEGQKQSAILASEAVGDAQAKTMARDALAKSGVIEAQETGNAPPAPEQTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSE4</accession>
    <name>Q2GSE4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_09110</name>
    </gene>
    <organism evidence="3 4">
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227037.1">
        <property type="nucleotide sequence ID" value="XM_001227036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSE4"/>
    <dbReference type="STRING" id="306901.Q2GSE4"/>
    <dbReference type="GeneID" id="4394921"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09110"/>
    <dbReference type="eggNOG" id="ENOG502SKCU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011237_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GSE4"/>
    <dbReference type="OMA" id="DNGWSTI"/>
    <dbReference type="OrthoDB" id="5420905at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="358"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ85096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="828" mass="92678" checksum="D61A79FA97EB8B52" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSK8</accession>
    <name>Q2GSK8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_09046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226973.1">
        <property type="nucleotide sequence ID" value="XM_001226972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSK8"/>
    <dbReference type="GeneID" id="4394723"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09046"/>
    <dbReference type="HOGENOM" id="CLU_2183649_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSK8"/>
    <dbReference type="OrthoDB" id="4590423at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ85032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="109" mass="11773" checksum="E9CB308F0B791E10" modified="2006-03-21" version="1">MADGVGKFEQFVKFGTDAYGLERLLRLLQALVTILLFTPPTTTTITALLPPSLLPLLTPTRNHAPSANALPLSREAKPVLSATLTPTPTHWPALSTLEVTPPGIIHYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSQ5</accession>
    <name>Q2GSQ5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_08999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226926.1">
        <property type="nucleotide sequence ID" value="XM_001226925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSQ5"/>
    <dbReference type="STRING" id="306901.Q2GSQ5"/>
    <dbReference type="GeneID" id="4395200"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08999"/>
    <dbReference type="eggNOG" id="ENOG502S42E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067890_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSQ5"/>
    <dbReference type="OMA" id="EMTSTQI"/>
    <dbReference type="OrthoDB" id="444432at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071">
        <property type="entry name" value="5-NITROIMIDAZOLE ANTIBIOTICS RESISTANCE PROTEIN, NIMA-FAMILY-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071:SF2">
        <property type="entry name" value="FLAVIN-NUCLEOTIDE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="182" mass="19822" checksum="5EF889BBE7A3D8DC" modified="2006-03-21" version="1">MNTARSTDSQEEGVPMTIAASHLDGLVLSLTPNSHSYNYRSAILFGHATLVTDPAEKLYAMELITNSVVPGRWAHTRVPPNAAEMQSTSVLRVRVSTGSAKIRTGEPHDERGDMEDAGLLERVWTGVVPVYMVRGEPVAGGYNRVEGVPEYLEGWRGEVNEEAEVYAREAVGREVVAKKGGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSS4</accession>
    <name>TVP18_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Golgi apparatus membrane protein TVP18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">TVP18</name>
        <name type="ORF">CHGG_08980</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226907.1">
        <property type="nucleotide sequence ID" value="XM_001226906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSS4"/>
    <dbReference type="FunCoup" id="Q2GSS4">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GSS4"/>
    <dbReference type="GlyCosmos" id="Q2GSS4">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="GeneID" id="4395391"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08980"/>
    <dbReference type="eggNOG" id="ENOG502S3AC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118698_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSS4"/>
    <dbReference type="OMA" id="IYAQWLG"/>
    <dbReference type="OrthoDB" id="5591789at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019365">
        <property type="entry name" value="TVP18/Ca-channel_flower"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314:SF2">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10233">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01077">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000343017" description="Golgi apparatus membrane protein TVP18">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="159" mass="17675" checksum="8E5DC678756FA0BB" modified="2006-03-21" version="1">MTLKEEFATRNFSIYGQWLGILSMILCFALGIANLFTFRVLIIILSAVCLASSFVILFIEVPLLLRICPTSSKFDDAIRKITTNYMRAAAYAVMAVVQWLTLLSAATSLLAAAVFLSFTCICYLLAGHQGPGLCRQQDPGRRRRRADDCMSGRARLPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GT35</accession>
    <name>Q2GT35_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226796.1">
        <property type="nucleotide sequence ID" value="XM_001226795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GT35"/>
    <dbReference type="GeneID" id="4395756"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08869"/>
    <dbReference type="eggNOG" id="ENOG502S5UU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078844_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GT35"/>
    <dbReference type="OMA" id="GIWNIKD"/>
    <dbReference type="OrthoDB" id="5363135at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="1">
        <location>
            <begin position="36"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="141" mass="16138" checksum="3D9F8E2646D53178" modified="2006-03-21" version="1">MTSQVREQHTLTYLCAEEQGIELQIAKETQATGWKINKSPSTIEEKDMLKKLLTTPPVKKIDLHFPLGLEVTARNLKGVTIKDALDAIHKQFKKRADDELELPYLKGFEWDKEESWTRLIVHLRKDAGQAPTTGKKKKGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GT44</accession>
    <name>Q2GT44_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_08860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226787.1">
        <property type="nucleotide sequence ID" value="XM_001226786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GT44"/>
    <dbReference type="GeneID" id="4395787"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08860"/>
    <dbReference type="HOGENOM" id="CLU_1343095_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GT44"/>
    <dbReference type="OrthoDB" id="4564352at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="204" mass="22915" checksum="5B48F73B69FEA02F" modified="2006-03-21" version="1">MSSHEMNNGGDCLNIDWESVTSKVTYYGLDGLPEPIRKFYVVGQVIANSAVCDRHRMNLLTGYLNALDDASYWAIPEFCDPDFSRVQADSSVPSVDRCLMWMETLTAKWPLPASMFTDAGMYMLTEEQVWMEVFFWCSGCMGTSGQSKDQLWELLGFVAPYITADGRRMVDGLQGGSCPHPRVRYWLSSSIMMLLNINVASPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GT80</accession>
    <name>Q2GT80_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_08824</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226751.1">
        <property type="nucleotide sequence ID" value="XM_001226750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GT80"/>
    <dbReference type="GeneID" id="4394835"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08824"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_2_1"/>
    <dbReference type="InParanoid" id="Q2GT80"/>
    <dbReference type="OMA" id="CNPEKEI"/>
    <dbReference type="OrthoDB" id="4583255at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="385"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="691"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="724"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="757"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="787"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="856"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="889"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="925"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="955"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="991"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1024"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1054"/>
            <end position="1086"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ84810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1147" mass="124922" checksum="ECBDBA2ECE86E885" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTF2</accession>
    <name>Q2GTF2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Concanavalin A-like lectin/glucanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2005-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Giovannoni S.J."/>
                <person name="Cho J.-C."/>
                <person name="Ferriera S."/>
                <person name="Johnson J."/>
                <person name="Kravitz S."/>
                <person name="Halpern A."/>
                <person name="Remington K."/>
                <person name="Beeson K."/>
                <person name="Tran B."/>
                <person name="Rogers Y.-H."/>
                <person name="Friedman R."/>
                <person name="Venter J.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 148.51</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2006-02" db="EMBL/GenBank/DDBJ databases">
            <title>Annotation of the Chaetomium globosum CBS 148.51 Genome.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Birren B."/>
                <person name="Lander E."/>
                <person name="Galagan J."/>
                <person name="Devon K."/>
                <person name="Nusbaum C."/>
                <person name="Ma L.-J."/>
                <person name="Jaffe D."/>
                <person name="Butler J."/>
                <person name="Alvarez P."/>
                <person name="Gnerre S."/>
                <person name="Grabherr M."/>
                <person name="Kleber M."/>
                <person name="Mauceli E."/>
                <person name="Brockman W."/>
                <person name="Rounsley S."/>
                <person name="Young S."/>
                <person name="LaButti K."/>
                <person name="Pushparaj V."/>
                <person name="DeCaprio D."/>
                <person name="Crawford M."/>
                <person name="Koehrsen M."/>
                <person name="Engels R."/>
                <person name="Montgomery P."/>
                <person name="Pearson M."/>
                <person name="Howarth C."/>
                <person name="Kodira C."/>
                <person name="Yandava C."/>
                <person name="Zeng Q."/>
                <person name="Alvarado L."/>
                <person name="Oleary S."/>
                <person name="Untereiner W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 148.51</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226679.1">
        <property type="nucleotide sequence ID" value="XM_001226678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTF2"/>
    <dbReference type="STRING" id="306901.Q2GTF2"/>
    <dbReference type="GeneID" id="4395676"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08752"/>
    <dbReference type="eggNOG" id="ENOG502RJF6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066466_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GTF2"/>
    <dbReference type="OMA" id="KITNATH"/>
    <dbReference type="OrthoDB" id="2862635at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00977">
        <property type="entry name" value="SCYTLDPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208434" description="Concanavalin A-like lectin/glucanase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="30464" checksum="5053E8DA1B6FCB32" modified="2006-03-21" version="1">MRWTLAALFGSALVANQALAELTFTVEATKNGVPIPQSEIKLEPFEFGRTRMGGSSPTPVHRRIRRSNPTANSNNWCGSVNKTPSTNQIQVIHGTFQHPTCTQRAGVTTYPQAAANWVGIDGDSWKSALLQAGTVCKIDNSTGIVRNEAWWQWVPSAAYTITTMPVSADDWIEITIETTSTTAAEITLSNLSQGQTYTMKIASGPTLARVDADWVVERPYYGANLASFPTFTDVWFDEAWATRASGSLGILGARQYQIPGLGAVPGVAWISRRLVGSLSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU20</accession>
    <name>Q2GU20_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226461.1">
        <property type="nucleotide sequence ID" value="XM_001226460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GU20"/>
    <dbReference type="STRING" id="306901.Q2GU20"/>
    <dbReference type="GeneID" id="4395774"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08534"/>
    <dbReference type="eggNOG" id="ENOG502RJ2X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_430198_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GU20"/>
    <dbReference type="OrthoDB" id="4590847at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="636" mass="69333" checksum="8D37A718E1CA608F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU62</accession>
    <name>Q2GU62_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226419.1">
        <property type="nucleotide sequence ID" value="XM_001226418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GU62"/>
    <dbReference type="GeneID" id="4394821"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08492"/>
    <dbReference type="eggNOG" id="ENOG502TFIS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_650533_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GU62"/>
    <dbReference type="OrthoDB" id="5098293at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="422" mass="46635" checksum="81DE15A6DD38ABF4" modified="2006-03-21" version="1">MDPNKIPNSNSWANSAALEDDIWNPDWDEFSADPLQDAEFAVSTTDDNIRFQYETAQSIQELNQTAPLPPTNDPTPDRVGYLPTSILDRTAWESNTEAEKRKDVYSTGVALVLPTQKWIPVEEEDLALKDPNTTTPQQANVKPTASRCAPCRFAGEVQDLLVALREKIDQVSQFSSGESLESLFGGNLHGTLLTAWSCAYWLTVLLNWDDNALYLNPLTVGLHGGIDLADAKNLVLELTYSVAHHVQVLIQELCYRAAVSMSGADKHHNPTTICCALWIVFAATHKFEKRNFAATSLANLRYSDVLEAKVPFLQNDELFQNGGTARLGLMVPRPTNSTWDNHVSGLGITPRTDRPLIPTTSTLDFSASTARNTTVHALRRNAMALRRSVAEAEARRSKRRASRSPSVSGMNRRAKTCPSDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUE6</accession>
    <name>Q2GUE6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226335.1">
        <property type="nucleotide sequence ID" value="XM_001226334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUE6"/>
    <dbReference type="STRING" id="306901.Q2GUE6"/>
    <dbReference type="GeneID" id="4395536"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08408"/>
    <dbReference type="eggNOG" id="KOG4400">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058879_0_2_1"/>
    <dbReference type="InParanoid" id="Q2GUE6"/>
    <dbReference type="OMA" id="EHKQCYN"/>
    <dbReference type="OrthoDB" id="3863715at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000012">
        <property type="entry name" value="Cellular nucleic acid-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000016">
        <property type="entry name" value="Cellular nucleic acid-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000085">
        <property type="entry name" value="Zinc knuckle nucleic acid binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="222" mass="23191" checksum="8BB0991C9E9A37A3" modified="2006-03-21" version="1">MSSVSRRACYKCGELGHHAEACASPHRLCYNCKQPNHESNECPMPRTTKAKQCYHCQGLGHVQAECPTLRLSGAGAGNRCYNCDSIGHLARNCPNPPVPGAGRGGMVPRGGFAPVRGGFVGGPRPATCYKCGGPNHFARDCQAQAMKCYACGKLGHISRDCTAPNGGPLNTAGKTCYQCGEAGHISRDCANKAGPIGEMQPEVEMAGAPVMPQPVAPLAPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUH6</accession>
    <name>Q2GUH6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 16">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="11 16">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CHGG_08378</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 16">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11 16"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226305.1">
        <property type="nucleotide sequence ID" value="XM_001226304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUH6"/>
    <dbReference type="FunCoup" id="Q2GUH6">
        <property type="interactions" value="891"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GUH6"/>
    <dbReference type="GeneID" id="4394788"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08378"/>
    <dbReference type="eggNOG" id="KOG0944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009884_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GUH6"/>
    <dbReference type="OMA" id="FVPCEHT"/>
    <dbReference type="OrthoDB" id="361536at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02658">
        <property type="entry name" value="Peptidase_C19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14385">
        <property type="entry name" value="UBA1_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14386">
        <property type="entry name" value="UBA2_UBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000086">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000103">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000396">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000587">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000235">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000144">
        <property type="entry name" value="Ubiquitinyl hydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF664">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016308">
        <property type="entry name" value="UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11 16" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11 16" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10 11 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="19">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="19">
        <location>
            <begin position="151"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="18">
        <location>
            <begin position="302"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="17">
        <location>
            <begin position="583"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="17">
        <location>
            <begin position="644"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="737"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="197"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EAQ84364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="781" mass="85653" checksum="8BDDEDEDCD8DAAD7" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUR2</accession>
    <name>Q2GUR2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ87039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225948.1">
        <property type="nucleotide sequence ID" value="XM_001225947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUR2"/>
    <dbReference type="GeneID" id="4394495"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08292"/>
    <dbReference type="HOGENOM" id="CLU_1927353_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUR2"/>
    <dbReference type="OrthoDB" id="10485613at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="131" mass="14346" checksum="53E9C29A210ED7F5" modified="2006-03-21" version="1">MKGPSAGKPRGRPRKQQPQLQARRQTQEADCIVVAVTSETEAATSTPAGTTTKLGLLRLQEVEEDLYERETAPPRAYQRIIDALDSVDPEVEDTHDALLADGEADARLAREDAAALEEDDEGEEEDTTIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUT2</accession>
    <name>Q2GUT2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ87019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225928.1">
        <property type="nucleotide sequence ID" value="XM_001225927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUT2"/>
    <dbReference type="GeneID" id="4394504"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08272"/>
    <dbReference type="eggNOG" id="ENOG502RJC7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2454526_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUT2"/>
    <dbReference type="OrthoDB" id="4586102at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="89" mass="10265" checksum="A439978232D04549" modified="2006-03-21" version="1">MYRTKHFRWKLMHVWGILAHLGLVVAVAINYIYDLDKATRSITWSHLTAVETNYRPRELALVAASSDVFTFDRSTHALLKACLIMDQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV62</accession>
    <name>Q2GV62_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_08142</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225798.1">
        <property type="nucleotide sequence ID" value="XM_001225797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV62"/>
    <dbReference type="GeneID" id="4394156"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08142"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_6_1"/>
    <dbReference type="InParanoid" id="Q2GV62"/>
    <dbReference type="OMA" id="ILFITTH"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF158">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="80"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ86889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="541" mass="58343" checksum="80E8EDDA5E34CD42" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV82</accession>
    <name>Q2GV82_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pirin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_08122</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225778.1">
        <property type="nucleotide sequence ID" value="XM_001225777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV82"/>
    <dbReference type="STRING" id="306901.Q2GV82"/>
    <dbReference type="GeneID" id="4394352"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08122"/>
    <dbReference type="eggNOG" id="ENOG502QQ5A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045717_0_2_1"/>
    <dbReference type="InParanoid" id="Q2GV82"/>
    <dbReference type="OMA" id="TPWHPHR"/>
    <dbReference type="OrthoDB" id="198735at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="3">
        <location>
            <begin position="54"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="4">
        <location>
            <begin position="160"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ86869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="36543" checksum="452753CBCCBD31F9" modified="2006-03-21" version="1">MSTATKLLPRLIRQTFLAAEQSEGAGARVRRSIGTPKLRHFSPLPHARPLRRARMDHEDFAGNKGRLGPGDLQFMTAGRGIVHAEMPVERKDGRPNVGLQLWVDLPERLKACEPRYRDLKAEEVPVVEVDGGRVRVKVISGQSHGVDSVKDLAYTPVWLLDVEVKPGGSIVQPLPEGWNAFAYTLEGEVLIGEKGNQRTVGQYHNVVFEGEGQAVYAAVDEGAEKSARFVIVAGTPLDQKVVQYGPFVLTKQEDVYKAFMDYQTHSNGFERAEGWESEIGKRMVLSTCGPSAINSVGKTMPKLDENLRTSAAALPLPRGSISSKGLTHLPRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVK4</accession>
    <name>Q2GVK4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_08000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225656.1">
        <property type="nucleotide sequence ID" value="XM_001225655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVK4"/>
    <dbReference type="SMR" id="Q2GVK4"/>
    <dbReference type="FunCoup" id="Q2GVK4">
        <property type="interactions" value="714"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GVK4"/>
    <dbReference type="GeneID" id="4393355"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08000"/>
    <dbReference type="eggNOG" id="KOG1749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115574_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GVK4"/>
    <dbReference type="OMA" id="KFRWSQR"/>
    <dbReference type="OrthoDB" id="1713912at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003254">
        <property type="entry name" value="PRK04211.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ86747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="15828" checksum="B43E5E83EF51DF14" modified="2006-03-21" version="1">MSGGKPRGLNAARKLRNNRREQRWADLAYKKRALGTAFKSSPFGGSSHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKVTAFVPNDGCLNFVDENDEVLLAGFGRKGKAKGDIPGVRFKVVKVSGVGLLALWKEKKEKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVS3</accession>
    <name>Q2GVS3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1783-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225587.1">
        <property type="nucleotide sequence ID" value="XM_001225586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVS3"/>
    <dbReference type="GeneID" id="4393970"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07931"/>
    <dbReference type="eggNOG" id="ENOG502RZQV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092488_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GVS3"/>
    <dbReference type="OrthoDB" id="2100652at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014807">
        <property type="entry name" value="Coa1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042432">
        <property type="entry name" value="Coa1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08695">
        <property type="entry name" value="Coa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="26435" checksum="BAB70AC5A5AFB60B" modified="2006-03-21" version="1">MTKCETVGQRYARAKAVVNAWAETERDTAASFLMYQSGLNLSRSVDSKPPHNPNHAVEVNPAKDGRPSSPTAEEDSLEQTTFRWSRTLPLFAAALIIASISIFNYQKLSSPVVGATLYALRTSEKARAHLGDEIYFAQQIPWISGEMNQLHGRIDITFRVKGTRGGGVMRFTSFRPSPRGMFETTEWSLETDDGVVIDLLEDGDPFKAITGAEGPIEMVDLEEEESSAAATRGFRKMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GW17</accession>
    <name>Q2GW17_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225493.1">
        <property type="nucleotide sequence ID" value="XM_001225492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GW17"/>
    <dbReference type="STRING" id="306901.Q2GW17"/>
    <dbReference type="GeneID" id="4393164"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07837"/>
    <dbReference type="eggNOG" id="KOG0627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031225_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GW17"/>
    <dbReference type="OMA" id="SALWEFK"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="57638" checksum="814A0C2AC434E195" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GW27</accession>
    <name>VAC8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Vacuolar protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">VAC8</name>
        <name type="ORF">CHGG_07827</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the beta-catenin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225483.1">
        <property type="nucleotide sequence ID" value="XM_001225482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GW27"/>
    <dbReference type="SMR" id="Q2GW27"/>
    <dbReference type="FunCoup" id="Q2GW27">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GW27"/>
    <dbReference type="GeneID" id="4393666"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07827"/>
    <dbReference type="eggNOG" id="KOG4224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021483_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GW27"/>
    <dbReference type="OMA" id="VWDKPDG"/>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071563">
        <property type="term" value="C:Myo2p-Vac17p-Vac8p transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051656">
        <property type="term" value="P:establishment of organelle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061724">
        <property type="term" value="P:lipophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071562">
        <property type="term" value="P:nucleus-vacuole junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903044">
        <property type="term" value="P:protein localization to membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031503">
        <property type="term" value="P:protein-containing complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000243">
        <property type="entry name" value="Putative Vacuolar protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000095">
        <property type="entry name" value="Vacuolar protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045156">
        <property type="entry name" value="Vac8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47249">
        <property type="entry name" value="VACUOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47249:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0519">Myristate</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000256210" description="Vacuolar protein 8">
        <location>
            <begin position="2"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM 1">
        <location>
            <begin position="39"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM 2">
        <location>
            <begin position="77"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM 3">
        <location>
            <begin position="118"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM 4">
        <location>
            <begin position="159"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM 5">
        <location>
            <begin position="200"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM 6">
        <location>
            <begin position="243"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM 7">
        <location>
            <begin position="284"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM 8">
        <location>
            <begin position="325"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM 9">
        <location>
            <begin position="409"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-myristoyl glycine" evidence="1">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-palmitoyl cysteine" evidence="2">
        <location>
            <position position="4"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="560" mass="60841" checksum="B27FBCE4D9138471" modified="2007-01-23" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX08</accession>
    <name>Q2GX08_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_07496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225152.1">
        <property type="nucleotide sequence ID" value="XM_001225151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX08"/>
    <dbReference type="STRING" id="306901.Q2GX08"/>
    <dbReference type="GeneID" id="4394624"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07496"/>
    <dbReference type="eggNOG" id="ENOG502S344">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058846_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GX08"/>
    <dbReference type="OMA" id="ASHKTIT"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ86243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="33470" checksum="F84B55ECCC41C09D" modified="2006-03-21" version="1">MTLHPVNIAMADSLMSPQEVATCLLDQRNPAHNIAALEHRQRLIRTWGIPLGSNILEIGPGQGDFTVALADAVGPAGRIVAIDNCPPGYGTPPVEEAQAFILASHLGPRIEFVRGDPIEYLSSRTEPTAAASPKKFDFIVFCHCVWYFSKPHYLAQLLRVAPPWAGTALVAEWSLSTSLPEAFPHVLSALLNNTLESLQSDSSLRNIRTAQTPPQIIQAAESAGWALRMEQVIPPAPGQLDGRREARMVIASEYFKSDLEAVQVNEGVRQMLYAMRDAVAASVARLDGGIDAVRAMDVWLARFELSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXH5</accession>
    <name>Q2GXH5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224985.1">
        <property type="nucleotide sequence ID" value="XM_001224984.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GXH5"/>
    <dbReference type="GeneID" id="4394083"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07329"/>
    <dbReference type="eggNOG" id="ENOG502QVZH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002714_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GXH5"/>
    <dbReference type="OMA" id="QVGRIPQ"/>
    <dbReference type="OrthoDB" id="5382952at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="930"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1156"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1162"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1393"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="612"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1393"/>
            <end position="1402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1513" mass="163295" checksum="AC88836C004D114A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXT4</accession>
    <name>Q2GXT4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methionine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_07220</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="2"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001224875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXT4"/>
    <dbReference type="FunCoup" id="Q2GXT4">
        <property type="interactions" value="474"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GXT4"/>
    <dbReference type="GeneID" id="4393220"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07220"/>
    <dbReference type="eggNOG" id="KOG0436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_5_2_1"/>
    <dbReference type="InParanoid" id="Q2GXT4"/>
    <dbReference type="OMA" id="TFIVCEP"/>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
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        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="10">
        <location>
            <begin position="42"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="10">
        <location>
            <begin position="167"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="11">
        <location>
            <begin position="434"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="556"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="626"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="631"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ85967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="797" mass="89144" checksum="8D0C8B379CE297F8" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXY4</accession>
    <name>Q2GXY4_CHAGB</name>
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        <recommendedName>
            <fullName evidence="4">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_07170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224826.1">
        <property type="nucleotide sequence ID" value="XM_001224825.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="Q2GXY4">
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    </dbReference>
    <dbReference type="STRING" id="306901.Q2GXY4"/>
    <dbReference type="GeneID" id="4393257"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07170"/>
    <dbReference type="eggNOG" id="KOG3691">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004025_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GXY4"/>
    <dbReference type="OMA" id="WYKAIVT"/>
    <dbReference type="OrthoDB" id="272977at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007191">
        <property type="entry name" value="Sec8_exocyst_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048630">
        <property type="entry name" value="Sec8_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20652">
        <property type="entry name" value="Sec8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04048">
        <property type="entry name" value="Sec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec8 N-terminal" evidence="6">
        <location>
            <begin position="84"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec8 middle helical bundle" evidence="7">
        <location>
            <begin position="250"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="456"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="731"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ85917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="980" mass="108240" checksum="D2A1EA80DDEE6297" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GY04</accession>
    <name>Q2GY04_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_07150</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224806.1">
        <property type="nucleotide sequence ID" value="XM_001224805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GY04"/>
    <dbReference type="STRING" id="306901.Q2GY04"/>
    <dbReference type="GeneID" id="4394256"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07150"/>
    <dbReference type="eggNOG" id="KOG1257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011405_2_1_1"/>
    <dbReference type="InParanoid" id="Q2GY04"/>
    <dbReference type="OMA" id="YPNMVVQ"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000182">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF32">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="10">
        <location>
            <begin position="168"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="9">
        <location>
            <begin position="358"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="8"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="554"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ85897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="659" mass="72983" checksum="682E5A51246EABCB" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYW9</accession>
    <name>Q2GYW9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase II domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_06835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224491.1">
        <property type="nucleotide sequence ID" value="XM_001224490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYW9"/>
    <dbReference type="STRING" id="306901.Q2GYW9"/>
    <dbReference type="GeneID" id="4394103"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06835"/>
    <dbReference type="eggNOG" id="KOG1284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020273_2_3_1"/>
    <dbReference type="InParanoid" id="Q2GYW9"/>
    <dbReference type="OMA" id="CSTAYQE"/>
    <dbReference type="OrthoDB" id="5569761at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019238">
        <property type="term" value="F:cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF29">
        <property type="entry name" value="GTP CYCLOHYDROLASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="3">
        <location>
            <begin position="7"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ85582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="137" mass="15178" checksum="E31E783A9EFFA2EE" modified="2006-03-21" version="1">MSLPSNEAGGIIIYLRQEGRGIGLGEKLKAYNLQDLGSDTVEANLLLRHPADARSYGLATSMLRDLGQNEVRLLTNNPDKVRAVEGPHREIVVKERVAMVPLSWKGRGGFRAPEVEGYLKTKIEKMGHMLDMANLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZ39</accession>
    <name>Q2GZ39_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224421.1">
        <property type="nucleotide sequence ID" value="XM_001224420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZ39"/>
    <dbReference type="GeneID" id="4391858"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05207"/>
    <dbReference type="eggNOG" id="ENOG502SPJJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_25_0_1"/>
    <dbReference type="InParanoid" id="Q2GZ39"/>
    <dbReference type="OrthoDB" id="5082906at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="268" mass="30055" checksum="8A4AE7606008F8C9" modified="2006-03-21" version="1">MYLNKRLADFENRLQDPIWTTSRGGKKTAASVVLTACRKIQQRLSSRRGNRGRPRTLGPQGPTAVERAAGTVMRWTGGTVDTNRVVEEAWKARWLKERDGRAITRPADDFDHQQETLFRNETLRRHDGLSKAKSSLLIQIRTGAIGLRDFLFTRGVPEVLTPACECGEGRETAEHLVVWCLAPPLTRRWERTGIRTRRDFYSVLHGINPTTCTAREESSRLADGLGEAADVQLSQEARAGSGGLKRPRSEARRPPLFVYVGSLKRIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H070</accession>
    <name>Q2H070_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_04826</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224040.1">
        <property type="nucleotide sequence ID" value="XM_001224039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H070"/>
    <dbReference type="FunCoup" id="Q2H070">
        <property type="interactions" value="277"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H070"/>
    <dbReference type="GeneID" id="4393015"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04826"/>
    <dbReference type="eggNOG" id="KOG3114">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059606_2_1_1"/>
    <dbReference type="InParanoid" id="Q2H070"/>
    <dbReference type="OMA" id="VFRRCVA"/>
    <dbReference type="OrthoDB" id="10256463at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="102"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ88207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="295" mass="31931" checksum="F0F59417079694F2" modified="2006-03-21" version="1">MSRSGYDAVVDVDDEGDLGHTDLQEDLEFHNSNFSETNPARGGGGIGGHKSPSLPLPATANTSSSSSQPGGGGKRMLWTMSFYAQFFDVDTSSVLHRCWAALYPRANFLDVLDGNPDLYGPFWIATTVVLILFLGGTISDYSAREGRGEFAYDFGLLSGAAGLIYGYTFVIPVVLYLALRYFGSESANLLECWALYGYGNLTWIPVALISWSPIAILNWVFVGVGFGVSVAFLLRNLYPVLSATDRQTSKVLLILVVALHFGLAIAIKVLFFAHGSPALKDGGEKTDPAPERMMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H105</accession>
    <name>Q2H105_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cystathionine beta-lyase</fullName>
            <ecNumber evidence="3">4.4.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cysteine-S-conjugate beta-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_04541</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L,L-cystathionine + H2O = L-homocysteine + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13965"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:18121"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29256"/>
            <dbReference type="ChEBI" id="CHEBI:58717"/>
            <dbReference type="EC" id="4.4.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from L-cystathionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.13" evidence="3"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223755.1">
        <property type="nucleotide sequence ID" value="XM_001223754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H105"/>
    <dbReference type="FunCoup" id="Q2H105">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H105"/>
    <dbReference type="GeneID" id="4392334"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04541"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_2_1_1"/>
    <dbReference type="InParanoid" id="Q2H105"/>
    <dbReference type="OMA" id="NCIGATG"/>
    <dbReference type="OrthoDB" id="2545919at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047804">
        <property type="term" value="F:cysteine-S-conjugate beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000013">
        <property type="entry name" value="Cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000009">
        <property type="entry name" value="Cystathionine gamma-synthase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006238">
        <property type="entry name" value="Cys_b_lyase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01329">
        <property type="entry name" value="cysta_beta_ly_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF50">
        <property type="entry name" value="CYSTATHIONINE BETA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 13 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ87922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="444" mass="47864" checksum="8474DF81ECBCE736" modified="2006-03-21" version="1">MATPNRMSPASQAANKVFTRVDVDGHALPPSPAPSSPLSGRKRYALATELVYTESKDQYGSSSIPIYQSATFKQTSSNGGNEYDYTRSGNPTRTHLERHLAKIMNATRALAVGSGMGALDVITRLLKPGDEVITGDDLYGGTNRLLTYLKNNQGVVVHHVDTTNADSVTTVISDKTAMVLLETPTNPLIKIVDIPSIARATHEANSKALVVVDNTMLSPMLLNPLDIGADIVYESGTKYLSGHHDIMAGVIACNDPELGDKMYFTINATGCGLSPNDSFLLMRGIKTLAIRMEKQQGNAQRIAEFLESHGFRVRYPGLKSHPQYDLHWSMARGAGAVLSFETGDVALSERIVEAARLWGISVSFGCVNSLISMPCRMSHASIDAKTRQERQMPEDIIRLCVGIEDADDLIDDLSRALVQAGAVTVSLDGFHANDTDAEGATVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H355</accession>
    <name>Q2H355_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_03791</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the complex I NDUFS4 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223005.1">
        <property type="nucleotide sequence ID" value="XM_001223004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H355"/>
    <dbReference type="STRING" id="306901.Q2H355"/>
    <dbReference type="GeneID" id="4392384"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03791"/>
    <dbReference type="eggNOG" id="KOG3389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077196_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H355"/>
    <dbReference type="OMA" id="YDATIDH"/>
    <dbReference type="OrthoDB" id="3089at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.190:FF:000001">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 21 kDa subunit mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.190">
        <property type="entry name" value="atu1810 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006885">
        <property type="entry name" value="NADH_UbQ_FeS_4_mit-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038532">
        <property type="entry name" value="NDUFS4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219:SF8">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04800">
        <property type="entry name" value="NDUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ87172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="208" mass="23184" checksum="9AF15A269F448399" modified="2006-03-21" version="1">MASLRTTASAARLLCSASHARTAVLPAARRYESSTTVPAKTEQEKKETSPMATLPRNSPDYNVPIDMATSTYTPVPKHVQDGSEEGVIPAGLLSNAPMELQARTVRIYKPTKPATQSGTQIGTRWRMDWDVLGKGHRWENPLMGWQSSGDFMQGTHIHFKSKEDAIAFAEKQGYEYFVQEPNARKFAPKAYANNFLYSPGKLKHIRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H365</accession>
    <name>Q2H365_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP-binding protein ryh1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222995.1">
        <property type="nucleotide sequence ID" value="XM_001222994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H365"/>
    <dbReference type="FunCoup" id="Q2H365">
        <property type="interactions" value="405"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H365"/>
    <dbReference type="GeneID" id="4391623"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03781"/>
    <dbReference type="eggNOG" id="KOG0094">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_2_1"/>
    <dbReference type="InParanoid" id="Q2H365"/>
    <dbReference type="OMA" id="NESEGGC"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01861">
        <property type="entry name" value="Rab6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17057" checksum="371A8F02247ECC17" modified="2006-03-21" version="1">MYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSSVAVVVYDISNAKSFQNTRKWIDDVRAERGNDVIIVLVGNKTDLNDKREVTTQQGEDEAKRNNLMFVETSAKLGHNVKTLFKRIAQALPGMEGADAVAQAANQMIDVKTPAAPAQQEGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H416</accession>
    <name>Q2H416_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">IMP-specific 5'-nucleotidase 1</fullName>
            <ecNumber evidence="12">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_06599</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = inosine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27718"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="3.1.3.99"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ISN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="12"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222694.1">
        <property type="nucleotide sequence ID" value="XM_001222693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H416"/>
    <dbReference type="FunCoup" id="Q2H416">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H416"/>
    <dbReference type="GeneID" id="4391138"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06599"/>
    <dbReference type="eggNOG" id="ENOG502QR24">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031816_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H416"/>
    <dbReference type="OMA" id="WGVLACQ"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006190">
        <property type="term" value="P:inosine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071590">
        <property type="term" value="P:nicotinamide riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071592">
        <property type="term" value="P:nicotinic acid riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009453">
        <property type="entry name" value="ISN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213:SF1">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06437">
        <property type="entry name" value="ISN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028836">
        <property type="entry name" value="ISN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ89980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="431" mass="47673" checksum="E4DC4873BAF69320" modified="2006-03-21" version="1">MTTRYRVECETSSMRTATPLKPRRARTAVHRYELSRAWQSMNDLAQTREEAHRRYSEILRDVEVMIDDHIAHQHDAENPFPSKLKLLVPSIGPFFTRLPLEAGFKFQDHKRYISSRRFVSPSFNDVRLILNSAQMMGRDQLRHPPARTFDGDVTLYDDGQSLEPSSPIVPRLIDLLRKNVKIGIVTAAGYTTADKYYARLHGLLDALANTAELTPTQKQSLIIMGGEANYLFEFSPSSPHLLAPVPRCRWLTPEMAAWDERDIAEVLDVAEAALGDCIKTLNLPAVLMRKDRAVGIVADPPSARIPRESLEETVLVVQKVLELSSAGRRGRVPFCAFNGGRDVFVDIGDKSWGVTVCQRWFAGGGNGNSGGDGGAAAIKGDNTLHVGDQFLSAGANDFRARSVGTTAWIASPAETVDLLDELAELMGKKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H480</accession>
    <name>Q2H480_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_06535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222630.1">
        <property type="nucleotide sequence ID" value="XM_001222629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H480"/>
    <dbReference type="STRING" id="306901.Q2H480"/>
    <dbReference type="GeneID" id="4390217"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06535"/>
    <dbReference type="eggNOG" id="ENOG502RKWV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1015643_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H480"/>
    <dbReference type="OMA" id="APDACYL"/>
    <dbReference type="OrthoDB" id="4589772at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="30362" checksum="7A0EAAB9FB57D9E0" modified="2006-03-21" version="1">MLVRRGLRLMDRVIEAPMDALPSPYARRLQDIYSSHAPPGFEHVPDGMDFAGDFVLRQAASTLRQVPNLDSLHYHQCCDVTKSFSVSLSQATAGPPPLRNVTELILTDTFMTAVSFRNLLEAIGPKLSKVSIQGIETETESRRMSRNGKTVGFGEAVLALQPWKRELKVLRFTNDKMDLAPDACYLKGIHALRNLQALETIEAPTPSFDVYGQLGNQEDALTLTLPAFVRELQLPGLPEKVQMVPSLRGLARALRAGQFVTISPTQIHKWSPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4B5</accession>
    <name>Q2H4B5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chitin biosynthesis protein CHS5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_06500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222595.1">
        <property type="nucleotide sequence ID" value="XM_001222594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4B5"/>
    <dbReference type="STRING" id="306901.Q2H4B5"/>
    <dbReference type="GeneID" id="4390724"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06500"/>
    <dbReference type="eggNOG" id="ENOG502QRF7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019904_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4B5"/>
    <dbReference type="OMA" id="ACEQNGR"/>
    <dbReference type="OrthoDB" id="245697at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17742">
        <property type="entry name" value="BRCT_CHS5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000453">
        <property type="entry name" value="Chitin biosynthesis protein CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031673">
        <property type="entry name" value="Chs5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052827">
        <property type="entry name" value="CHS_Export/Cell_Fusion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031669">
        <property type="entry name" value="Fn3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351:SF1">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16892">
        <property type="entry name" value="CHS5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16893">
        <property type="entry name" value="fn3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="66"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="154"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ89881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="42497" checksum="5DB0E3E2F683D22E" modified="2006-03-21" version="1">MLVSLTVGKVDAGVTIEFPSILLPPDIASGSIVDINVTRNKNSETVAERSFRELQDSILSCFGAAEPSAPVLRCRNATQTSVVLEWDPIQLATADLISLALYRNGQKAGNIPKPLAMHTTKISGLAVDTEYTFHLVLRTTAGTTASQRVTVRTHKMTDLSGITITTGILPAAVREGLGAAVERIGAKIVDGVRIDTTHFVTTEGRGLQWEKANELNIPIVRPEWVEACERNGRILGVTKFYLDAVRAGPPFEDRPGTAGTVGTTTTTGTTTTVAPPATAPSPPQKDDQTPQNAPSPNSNQAPEPSSENGAGQKEEGGTESDSSSDDGEEIQEEQKARSGGQDEQKMLADERDEKRLVERPKPTVEDEADDDTEEEKAAGQDEKDGKPGGDGASFQDVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4E4</accession>
    <name>Q2H4E4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_06471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222566.1">
        <property type="nucleotide sequence ID" value="XM_001222565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4E4"/>
    <dbReference type="GeneID" id="4391191"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06471"/>
    <dbReference type="HOGENOM" id="CLU_1906508_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4E4"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="133" mass="14114" checksum="BCF3E90D756745B3" modified="2006-03-21" version="1">MTSSGELEAPMHTFAQPFGVAVSVRRRCPAGSITRNKGSGDASACPPPLRVHVGQSFCYFPSPLCPCPPSRPKMERKWKCKPGEANAVSQVPVCRSPTPSSPLNARLFALATPRSFPPISGAALGFSAQYPIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4P0</accession>
    <name>Q2H4P0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_06375</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
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        <property type="nucleotide sequence ID" value="XM_001222469.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="Q2H4P0">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H4P0"/>
    <dbReference type="GeneID" id="4390338"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06375"/>
    <dbReference type="eggNOG" id="KOG4419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_470895_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4P0"/>
    <dbReference type="OrthoDB" id="7722975at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Ser/Thr protein phosphatase family"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
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    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053828">
        <property type="entry name" value="Nucleosidase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF43">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE FAMILY (AFU_ORTHOLOGUE AFUA_3G04160)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21953">
        <property type="entry name" value="NadN_nucleosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208918" evidence="2">
        <location>
            <begin position="22"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="43"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Putative 5'-nucleotidase C-terminal" evidence="4">
        <location>
            <begin position="242"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="454"/>
        </location>
    </feature>
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        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="430"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ89756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="579" mass="64671" checksum="B1523FC4E9198303" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4R1</accession>
    <name>Q2H4R1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pal1 cell morphology protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222449.1">
        <property type="nucleotide sequence ID" value="XM_001222448.1"/>
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    <dbReference type="STRING" id="306901.Q2H4R1"/>
    <dbReference type="GeneID" id="4391225"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06354"/>
    <dbReference type="eggNOG" id="ENOG502S21G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025891_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H4R1"/>
    <dbReference type="OMA" id="GPSMIHH"/>
    <dbReference type="OrthoDB" id="5352132at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013226">
        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF2">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="32"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="270"/>
        </location>
    </feature>
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        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
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        <location>
            <begin position="404"/>
            <end position="558"/>
        </location>
    </feature>
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        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
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            <end position="120"/>
        </location>
    </feature>
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            <begin position="140"/>
            <end position="179"/>
        </location>
    </feature>
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        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
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        <location>
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            <end position="219"/>
        </location>
    </feature>
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        <location>
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            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
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        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
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        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
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        <location>
            <begin position="491"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ89735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="61460" checksum="22061B3DFE24E83E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4W3</accession>
    <name>Q2H4W3_CHAGB</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_06302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89683.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001222396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4W3"/>
    <dbReference type="GeneID" id="4390673"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06302"/>
    <dbReference type="HOGENOM" id="CLU_997487_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4W3"/>
    <dbReference type="OrthoDB" id="4583508at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="151"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="279" mass="31758" checksum="C4CD4A95DB56BC5B" modified="2006-03-21" version="1">MSPPTIDVRAIAAAALDLSSAAQGHHHVNVINPPSFALPPLEPRSIPAPTNNNNRLPQLPPLNSVFFPWSPIQVQQHHPYLLQQPVVSTGPRIPPPGYPDAAWHPHLLLHPPAPVSTPVLLPHSRHWPGEPVRPLQPAPNVNEQHAEIQFGSERLGQPPQTGPRGEGQDEESGAQQTLPPRKLVERFRASLEEQLKLDYRCFDQKARQQKQAELAELERENKTFKLQKKAAEKITDEKQRAYQLDRVNRNHVKRVVNIRKRHRRYPRAQEVWQITTTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4X4</accession>
    <name>Q2H4X4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_06291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222386.1">
        <property type="nucleotide sequence ID" value="XM_001222385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4X4"/>
    <dbReference type="GeneID" id="4390650"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06291"/>
    <dbReference type="eggNOG" id="KOG0594">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1844850_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4X4"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="15686" checksum="E0FB7689D67BE10F" modified="2006-03-21" version="1">MMDMPKQSDGTLGFRNVQITDLEEAFVVPPNSQGLGKRLSGNQFWRSPEAWARGAQNTSADIFSFGIVAIYVWLDRMIFYSDEANKAEDPSDMILRRHVSFLNDIDDFHGFIEYHGGENDPFVSRFGGLLISSRVLFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H665</accession>
    <name>Q2H665_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_05850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221945.1">
        <property type="nucleotide sequence ID" value="XM_001221944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H665"/>
    <dbReference type="FunCoup" id="Q2H665">
        <property type="interactions" value="379"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H665"/>
    <dbReference type="GeneID" id="4390939"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05850"/>
    <dbReference type="eggNOG" id="KOG3188">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1199671_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H665"/>
    <dbReference type="OMA" id="GWINCAF"/>
    <dbReference type="OrthoDB" id="6745403at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045050">
        <property type="term" value="P:protein insertion into ER membrane by stop-transfer membrane-anchor sequence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ89231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="231" mass="25879" checksum="1B4C618F1C0E35EE" modified="2006-03-21" version="1">MKSAWLEVPADPSDDNSHASGADETPSARLLEEKQFNQRKAVGNDEMAQVPVQTIHRDPQLFYWILFPITIVMILTGVLRHYATVLMASAPKKQDQKTTLGSPDAFAWDWMEWLTRPVKLPFPLTIKFKSMLQAGVATRDMDPRWMSSISWYFLCIFGLQSVFNFLLGSENAANQMAQQMNQMGPQGAGQMFGPGVDPNKQFLAEAENLAVIEHHSVLDGVEQRLLAGIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6F3</accession>
    <name>Q2H6F3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CoA-transferase family III</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221857.1">
        <property type="nucleotide sequence ID" value="XM_001221856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6F3"/>
    <dbReference type="STRING" id="306901.Q2H6F3"/>
    <dbReference type="GeneID" id="4390794"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05762"/>
    <dbReference type="eggNOG" id="KOG3957">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021588_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H6F3"/>
    <dbReference type="OMA" id="DANIGKH"/>
    <dbReference type="OrthoDB" id="2308815at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052985">
        <property type="entry name" value="CoA-trans_III_biosynth/detox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229:SF1">
        <property type="entry name" value="ALPHA METHYLACYL-COA RACEMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229">
        <property type="entry name" value="CAIB/BAIF FAMILY ENZYME (AFU_ORTHOLOGUE AFUA_1G05360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="658" mass="71640" checksum="F4EA6B4EFF6B8844" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6G0</accession>
    <name>Q2H6G0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221850.1">
        <property type="nucleotide sequence ID" value="XM_001221849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6G0"/>
    <dbReference type="GeneID" id="4391056"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05755"/>
    <dbReference type="HOGENOM" id="CLU_2049418_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6G0"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="120" mass="11563" checksum="89FF9CE45DEB993A" modified="2006-03-21" version="1">MTITIAGDGDGGKDGVPSLGDGDGDGGGGGVGLGLGLGLDGGHGGLVNGAVAGGGGTAATATVAGVGAKCECEKSRWEWQQWQLRQTTVRGKGLGSEVAAAAVAGGRFLRKAVRSSARKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6T9</accession>
    <name>Q2H6T9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221721.1">
        <property type="nucleotide sequence ID" value="XM_001221720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6T9"/>
    <dbReference type="GeneID" id="4390126"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05626"/>
    <dbReference type="HOGENOM" id="CLU_2483154_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6T9"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="87" mass="9671" checksum="C590109112916A72" modified="2006-03-21" version="1">MCRKPHLSTHPTEGLQGGRASLTHRPVCPSNLNPQGYRQCNGPLQKGEEYGQWQNGAPTIAVRVALRIRPRLDRMCVRRADPADGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6X3</accession>
    <name>Q2H6X3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Ornithine aminotransferase</fullName>
            <ecNumber evidence="4 9">2.6.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_05592</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2-oxocarboxylate + L-ornithine = L-glutamate 5-semialdehyde + an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:13877"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="EC" id="2.6.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="4 9"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221687.1">
        <property type="nucleotide sequence ID" value="XM_001221686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6X3"/>
    <dbReference type="FunCoup" id="Q2H6X3">
        <property type="interactions" value="691"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H6X3"/>
    <dbReference type="GeneID" id="4390553"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05592"/>
    <dbReference type="eggNOG" id="KOG1402">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_3_1"/>
    <dbReference type="InParanoid" id="Q2H6X3"/>
    <dbReference type="OMA" id="RSAWDLC"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:L-arginine catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006591">
        <property type="term" value="P:ornithine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000011">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000152">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ88973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="452" mass="49185" checksum="01589693D934F943" modified="2006-03-21" version="1">MRCQRGRDRGLGVPLVTALADWATKATPSTIDGWGRSLCVGTPGSPGIFGSTAIAAENEFAAHNYHPLPVVFARAQGVHVWDPEGKHYLDFLSAYSAVNQGHCHPELIKALTEQAGRLTLSSRAFHNDVFPVWAQKVRQLFGFDMVLPMNTGAEAVETAIKIARKWAYKVKGVAPGKALVFSASDNFHGRTMTAVSLSLDPESRDNYGPYLPNVGATNPTTGQPIRYNSIPDLEAVLEAYGRDTAAFIVEPIQGEAGVVVPDDDYLARAQTLCRKHNVLLVCDEIQTGIARTGRMLCSEWSGIKLDMVTLGKAISGGMYPHPGSTYDGNARLRRVHPRPRANREEGLVEKAERLGRVFRESVEAFQSPLVQVVRGKGLLNAVVIDESKADGRSAWELCLLLKEKGVLAKPTHGNIIRFAPPLVITEEELRGAIKIIGEALKELPTTTISEGH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H740</accession>
    <name>MDM10_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial distribution and morphology protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Mitochondrial inheritance component MDM10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MDM10</name>
        <name type="ORF">CHGG_05525</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. Associates with the mitochondrial outer membrane sorting assembly machinery SAM(core) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text>Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM10 family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAQ88906" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88906.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221620.1">
        <property type="nucleotide sequence ID" value="XM_001221619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H740"/>
    <dbReference type="SMR" id="Q2H740"/>
    <dbReference type="FunCoup" id="Q2H740">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H740"/>
    <dbReference type="GeneID" id="4391369"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05525"/>
    <dbReference type="HOGENOM" id="CLU_026505_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H740"/>
    <dbReference type="OrthoDB" id="2103793at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03102">
        <property type="entry name" value="Mdm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027539">
        <property type="entry name" value="Mdm10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12519">
        <property type="entry name" value="MDM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="chain" id="PRO_0000384173" description="Mitochondrial distribution and morphology protein 10">
        <location>
            <begin position="1"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="430" mass="46853" checksum="7D0A2F213430B754" modified="2009-09-22" version="2">MREFMHYVTNAFYGATGWNDDNTYKELNVTARELIDFPLPRGLRLTLSSLATPHFATSYQLGSVGIVDGSISYLHSSVPLTGIAARSDRIPLPALLRSYRRLHDLGSKDQQQYVGAEHAPTESTPPAVAKVDGSSLLYGRLYLPQSLLEGMVVRRFTPALQVQLSAVSERSLRNGGTLLGLVQYDKRKYGVEGLASTDGGLLGVRGLYNFGGDASSSAMNPPSGTSASETNGSGPSVEKERIYGRFSAGAELYYGTLNKSGGMSLGARFATLPAHRGTPLTATLTINPLMGNINATYAVLAREYCSLATKMEFNVYSYESEWAVGVELWSNRRPAGFLLGANPNDQAEPAPEPPRKSNERSFQAKMEWRLDDPEPEPQSPVAGEKSADDGPKEEYKGVLKARFDQNFRFGLLWEGRVKSLIFSLGTGRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7C4</accession>
    <name>Q2H7C4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_05441</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221536.1">
        <property type="nucleotide sequence ID" value="XM_001221535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7C4"/>
    <dbReference type="GeneID" id="4390890"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05441"/>
    <dbReference type="eggNOG" id="ENOG502SY1T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1547365_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7C4"/>
    <dbReference type="OrthoDB" id="4587574at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ88822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="18327" checksum="C433C54162778BAB" modified="2006-03-21" version="1">MDWFQCRATVPASGMTLSLVGSNTETYTALQTVISPEVIYAYGIRMVYEATDLTTASPTASATSSITSSATSPPSSGSKPAASSGLSIGATVAICVAITLAVLAVSVAAFLLWQRKRRQRQSRAAAAAWEKSHELPAKPHERSLPNSPHEMTSDEVMAEMPGTRNTVELPARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7F8</accession>
    <name>Q2H7F8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221502.1">
        <property type="nucleotide sequence ID" value="XM_001221501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7F8"/>
    <dbReference type="GeneID" id="4390256"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05407"/>
    <dbReference type="eggNOG" id="ENOG502S5MR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099492_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7F8"/>
    <dbReference type="OrthoDB" id="4286061at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="244" mass="26435" checksum="C688FB5729A21D5D" modified="2006-03-21" version="1">MGAAVLDLYLNKLLADFETRLQRTDLDDGQGGKKTAGSVILTAWSKIQRTTLEERQQGPAANCGTAGAHGGGESRENDRALDGGNRRYEQGDAIPERNPKEARRSQQGEELTADSNPDGSNRLTGLLVYTGSPGGFDSCLRVWRGTRDCRTPGSVVFGPTVDSKMGENWNSDTTGLLLCSTRHQSHDCTAREESPRLADGLGEAADVQLSQEARARSGGLKRPRPEARRPPLFIYADSPERIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7P3</accession>
    <name>Q2H7P3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221417.1">
        <property type="nucleotide sequence ID" value="XM_001221416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7P3"/>
    <dbReference type="GeneID" id="4391235"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05322"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_0_4_1"/>
    <dbReference type="InParanoid" id="Q2H7P3"/>
    <dbReference type="OMA" id="YEDEWTY"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="46633" checksum="BD5473D2FC34C707" modified="2006-03-21" version="1">MASSPKSNDPTTSKPQPRQGTTSPGRESGVVQGHEHDHPQEEQQQAVIPVPLQVDNDIDDDDNSDGDSAYGSLAGSSRTGSITSSITNYVYENGRRYHAYRSGQYVLPNDDAEQERLDLQHHIWRLLVQGALYTAPLHIPQPGERSTSTSSGSTSTNGSDFRILDLGCGTGIWAIDMADQFPRASVFGVDLSPIQPEWVPGNCRFHVDDYEDEWTYRDDEAFDYIHGRALSGTVANDAWPNFYRQVRQNLKPGGWCEMQEYDAWIFSDDDSYERAPWTREWVEKLDEASTMFGKTINVARKHKQWMIDAGFEDVEEKTIRIPIGPWAKDPALKELGRFEQLHMQMSVASHTPALFTRVWSYTEPQVQLLIEGVKREFRSRDLSKCNPIVSHELQESPKACQLQTPAAVPNSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H845</accession>
    <name>Q2H845_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230125.1">
        <property type="nucleotide sequence ID" value="XM_001230124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H845"/>
    <dbReference type="GeneID" id="4389454"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03609"/>
    <dbReference type="eggNOG" id="ENOG502TA64">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1488836_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H845"/>
    <dbReference type="OMA" id="ERGRWHS"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="181" mass="20122" checksum="419480EAE9E0007F" modified="2006-03-21" version="1">MEVTTPTPPTPHLQARTRIITQTITRPFTTITALVTLGGDSPELTTNNPPPSPTPPPPPPAPTNQQLAPAAPPSALTPSQLGAVLGSVLGLATLILLICCILSLQRRKRRLERQQNDRYYYYDDGDEDEDEEMRERGRWHSRSGRGSWTTVPPPVRFPPTPRYTTYSQTRERQIGGVGRYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8J9</accession>
    <name>Q2H8J9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Auxiliary Activity family 9 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_03455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </evidence>
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    </evidence>
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        <source>
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</entry>
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                <person name="Untereiner W.A."/>
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            <dbReference type="PubMed" id="25720678"/>
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        </source>
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            <end position="204"/>
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            <dbReference type="PubMed" id="25720678"/>
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        </source>
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            <end position="1143"/>
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            <end position="32"/>
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    </feature>
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        <location>
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        <location>
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            <end position="1128"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1176" mass="128387" checksum="7BBB53ADB501048E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9B6</accession>
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                <person name="Untereiner W.A."/>
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            <dbReference type="PubMed" id="25720678"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <subcellularLocation>
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        <property type="project" value="UniProtKB-KW"/>
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    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
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        <location>
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            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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            <end position="194"/>
        </location>
    </feature>
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        <location>
            <begin position="41"/>
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        </location>
    </feature>
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            <begin position="69"/>
            <end position="79"/>
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    </feature>
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            <begin position="182"/>
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        </location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ91253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="292" mass="31638" checksum="D45E1E15A64C7257" modified="2006-03-21" version="1">MASEQDPPAPAQHQRQPQPQDPDTEMPDHHHQQPPAPPSQTDPSAATTTEATEPPPPNQPESQPQDQPQETREPQEKKQPPPPPPAPGPRAARLQALFASTAKHTLDKINKENFGACFPTISDKAPGTLEFVQRQMVERLGGLWNKEFETIMTNRQVVARLNELEELVSDAARRRTESDDPNSPPVPPHTLPAPTILHAHLTPHLASHQSQLNAKLQNTQAANARLWDEIRAQRAEMEALLAGVEKAVRDTEGANALLGEVADELAAETRAAEKDVRGVSVGSVGGGGGVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9D0</accession>
    <name>Q2H9D0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">T-complex protein 1 subunit theta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_03174</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229690.1">
        <property type="nucleotide sequence ID" value="XM_001229689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9D0"/>
    <dbReference type="FunCoup" id="Q2H9D0">
        <property type="interactions" value="1340"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H9D0"/>
    <dbReference type="GeneID" id="4389595"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03174"/>
    <dbReference type="eggNOG" id="KOG0362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_4_2_1"/>
    <dbReference type="InParanoid" id="Q2H9D0"/>
    <dbReference type="OMA" id="WGLKYAV"/>
    <dbReference type="OrthoDB" id="1748577at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ91239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="59473" checksum="68F4A3C11AC4A9F8" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9F1</accession>
    <name>Q2H9F1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_03153</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229669.1">
        <property type="nucleotide sequence ID" value="XM_001229668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9F1"/>
    <dbReference type="STRING" id="306901.Q2H9F1"/>
    <dbReference type="GeneID" id="4389033"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03153"/>
    <dbReference type="eggNOG" id="KOG4640">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011501_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9F1"/>
    <dbReference type="OrthoDB" id="2110451at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024789">
        <property type="entry name" value="APC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024790">
        <property type="entry name" value="APC4_long_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12896">
        <property type="entry name" value="ANAPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209096" description="Anaphase-promoting complex subunit 4" evidence="6">
        <location>
            <begin position="26"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4 long" evidence="7">
        <location>
            <begin position="159"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ91218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="671" mass="74138" checksum="DDD8E3D6C112EED1" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9F5</accession>
    <name>Q2H9F5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_03149</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229665.1">
        <property type="nucleotide sequence ID" value="XM_001229664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9F5"/>
    <dbReference type="FunCoup" id="Q2H9F5">
        <property type="interactions" value="1008"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H9F5"/>
    <dbReference type="GeneID" id="4389029"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03149"/>
    <dbReference type="eggNOG" id="KOG3181">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058591_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H9F5"/>
    <dbReference type="OMA" id="NKKKWMI"/>
    <dbReference type="OrthoDB" id="10248446at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.32:FF:000004">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000006">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_uS3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="9">
        <location>
            <begin position="24"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ91214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="260" mass="28394" checksum="DAC5A1EBD11C472E" modified="2006-03-21" version="1">MAVPGTQISKRRKFVADGVFYAELNEFFQRELAEEGYSGVEVRVTPTVTDIIIRATHTQEVLGEQGRRIRELTSLIQKRFKFPENSVSLYAAKVQNRGLSAVAQCESLRYKLLNGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRAARAKSMKFTDGFMIHSGQPAKDFIDSATRHVLLRQGVLGIKVKIMRGSDPEGKAGPQKSLPDAVTIIEPKDEAPVVQPMSQDYGAKAAAAQAAAEAARQEEQAGEEEPAPAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9U7</accession>
    <name>Q2H9U7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_03007</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229523.1">
        <property type="nucleotide sequence ID" value="XM_001229522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9U7"/>
    <dbReference type="STRING" id="306901.Q2H9U7"/>
    <dbReference type="GeneID" id="4388647"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03007"/>
    <dbReference type="eggNOG" id="KOG1404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_4_0_1"/>
    <dbReference type="InParanoid" id="Q2H9U7"/>
    <dbReference type="OMA" id="HAMANYF"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094:SF1">
        <property type="entry name" value="AMINOTRANSFERASE CLASS-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ91072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="45168" checksum="A763C639D0A4700F" modified="2006-03-21" version="1">MGQFLSSPSKSGNRILPRKTEHDITESTSDLGHPQTVVDGLPVLKKAKGHYWYPTKGPKILDACGGAAVACLGHGRRDIAKAVTAQMESYTYASYAHFQTTPVQELSDWLIKSTGGQMQKVYVMCSGSEAIEAALKLSVEYFRWKGEPERVNFIARLDSYHGTTLGSLSVSGHHARRAPFHPLLSPAHFHHIPACNPYREEDTTTPPTTSPSAYLAHKTAQLEAAFTHLGPHTVAAVVLEPVVGAALGCMPAPAGYLAAMQAVCARHGALLVLDEVMCGMGRTGWTHAWQGEGEGETLSGEGMGMGVVPDLQAVAKGFAGGYVPASALLVGGRVAGLMEREGRVFTHGHTYQNHPVVAAAALAVQRAVEREGLLGNVRVQGELLGRLLRERLGTHLNVGDVRGKGLFWGVEFVKDRGTKESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9Z6</accession>
    <name>Q2H9Z6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_02958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229474.1">
        <property type="nucleotide sequence ID" value="XM_001229473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9Z6"/>
    <dbReference type="STRING" id="306901.Q2H9Z6"/>
    <dbReference type="GeneID" id="4389752"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02958"/>
    <dbReference type="eggNOG" id="ENOG502RNKF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041826_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9Z6"/>
    <dbReference type="OMA" id="CSMMFPK"/>
    <dbReference type="OrthoDB" id="5352472at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ91023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="344" mass="37661" checksum="1903462655E92360" modified="2006-03-21" version="1">MPPQLLPASAAAFAPRASSVNVVLGSKVEPWLTQTLKRINKIKRPLNSVPQHQRCLTETLSSPNAIWNLASLLLPKAPDAELRRDPNPLIEAVLNYELNHLEAYIVHVDMVLRNEVAYKLTPETIESLIEYHKDIHCVDAKANTYDWSEKEQQCKKLHENFVQAINKFVYRTHVSALEGLEEDGAGELLGGRSEEVKNSIMGLFKPLLPPPPRIVDVVRQPPLLPSSPAGAAIWSQPSPPATMPAPVESWKILPSSPGVTSTSADSTGSIWVPMGMSEVQLPSPPPAFSQPYSTAGMYYSAPLVTAPVPQLPLPSMLAPQCGITVGYNSFGGWDTRYQEYAATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HA11</accession>
    <name>Q2HA11_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_02943</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229459.1">
        <property type="nucleotide sequence ID" value="XM_001229458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HA11"/>
    <dbReference type="FunCoup" id="Q2HA11">
        <property type="interactions" value="282"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HA11"/>
    <dbReference type="GeneID" id="4389538"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02943"/>
    <dbReference type="eggNOG" id="ENOG502QSY2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010084_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HA11"/>
    <dbReference type="OMA" id="DQGFQYF"/>
    <dbReference type="OrthoDB" id="422427at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <location>
            <begin position="410"/>
            <end position="483"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
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            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ91008.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1031" mass="115825" checksum="E996D2C4A5430131" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAF1</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02803"/>
    <dbReference type="HOGENOM" id="CLU_2497690_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HAF1"/>
    <dbReference type="OrthoDB" id="10528896at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="EAQ90868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="86" mass="9483" checksum="54E84B3B35BC3669" modified="2006-03-21" version="1">MPHTSIPTHGGVPVLRPEIGRLGKKHGACWSAREVCEKEEVEVEAKAPQVSVGPDVRRLVIQALWSAAKTRFSSPSLLRRQPLHPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="64" xmlns="https://uniprot.org/uniprot">
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    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Sordariomycetes</taxon>
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="42"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
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        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
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        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
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        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
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        <location>
            <begin position="517"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="803"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ90833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="958" mass="102478" checksum="9AFA2E52EF91A6F0" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAJ1</accession>
    <name>Q2HAJ1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
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                <person name="Untereiner W.A."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001229278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAJ1"/>
    <dbReference type="GeneID" id="4388478"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02763"/>
    <dbReference type="HOGENOM" id="CLU_3224499_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HAJ1"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="44" mass="4947" checksum="809A565CB65A5DFF" modified="2006-03-21" version="1">MDSTEEFQPRSSTQQQGADARVLTTRVWIEQQDNAIQAGGRILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBE1</accession>
    <name>Q2HBE1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228979.1">
        <property type="nucleotide sequence ID" value="XM_001228978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBE1"/>
    <dbReference type="GeneID" id="4389918"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02463"/>
    <dbReference type="HOGENOM" id="CLU_1360270_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HBE1"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="201" mass="21524" checksum="D920BBFBE6F90BE8" modified="2006-03-21" version="1">MAEKHGWPFIEWFRPREAHLDRSRRLLATGRYADDPSSISGPGWEDENPVTEARLKDGKAGNQEKVSARVPGLSQRPAAIPPTASPLTAPPLTTPQPLHTPPQAEPSNTAQTIPITIPIPPLPTEPNPKPKTEPNTETKANPKKEATKPLPLAPKAGRSRKRAASAALREGNEGGAGAGDGAGRPAVRRSPRVRARSLSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBL7</accession>
    <name>Q2HBL7_CHAGB</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001228902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBL7"/>
    <dbReference type="STRING" id="306901.Q2HBL7"/>
    <dbReference type="GeneID" id="4389864"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02387"/>
    <dbReference type="eggNOG" id="ENOG502SPXG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054097_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HBL7"/>
    <dbReference type="OMA" id="DPDNFGM"/>
    <dbReference type="OrthoDB" id="10037289at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="346" mass="38493" checksum="DE48219999A94B51" modified="2006-03-21" version="1">MAPKRGATAAAAPGRPSKKSNPSTGSQNNRNDAPAPTIPRSKRWTPLISCSANVDMEYKIATQDPETAYRHGAYGVLEVLQNLILDFEEAKDNLKERWAICEALAFFLNTNTAMGVVRYVLLVTSLGEQYNDTGLMGWHGVDGTTVTETYLIIGRLFLTALAQLEREDLLKEDSEIENIGLIMALFMAFSRTAKRCSQLLYDEYRRQSLVPAKDKRKWEPRDFHHQIASYASKYGISLVGPHDIDDLVAKAKSDADLPLPASNTPKADVFGFAKNLKRYKEEQNGLTAWMALTHCFTPIGGDSLDITTWSSDKRKEKHFEEKDPLTQEHLEALAQGKVISVASVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HC44</accession>
    <name>Q2HC44_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228726.1">
        <property type="nucleotide sequence ID" value="XM_001228725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HC44"/>
    <dbReference type="GeneID" id="4389500"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02210"/>
    <dbReference type="eggNOG" id="ENOG502T6IV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2265451_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HC44"/>
    <dbReference type="OrthoDB" id="3712072at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209193" evidence="1">
        <location>
            <begin position="20"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="103" mass="11541" checksum="55DE692F4F0D1DCC" modified="2006-03-21" version="1">MKCQTLLLVVAALVPSVLADKPKLNQYRTMDDCNNDANILYHAAPVSGRCYNLDDATGAFFWNTGGMLNPRVYTGKDCHGTEDPLSTRGRCYPKGIYRSYKCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCK9</accession>
    <name>Q2HCK9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_02045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221266.1">
        <property type="nucleotide sequence ID" value="XM_001221265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCK9"/>
    <dbReference type="STRING" id="306901.Q2HCK9"/>
    <dbReference type="GeneID" id="4386966"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02045"/>
    <dbReference type="eggNOG" id="KOG0269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002874_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCK9"/>
    <dbReference type="OMA" id="QTWRIVK"/>
    <dbReference type="OrthoDB" id="60955at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037590">
        <property type="entry name" value="WDR24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="152"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="248"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="421"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="665"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="757"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="837"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1108"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="436"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="476"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="837"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ93810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1256" mass="136786" checksum="4A774D975EBD6E9C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCQ8</accession>
    <name>Q2HCQ8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_01996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221217.1">
        <property type="nucleotide sequence ID" value="XM_001221216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCQ8"/>
    <dbReference type="GeneID" id="4386635"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01996"/>
    <dbReference type="HOGENOM" id="CLU_841975_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCQ8"/>
    <dbReference type="OrthoDB" id="4585632at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ93761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="330" mass="34835" checksum="B99FBDF3B51D573B" modified="2006-03-21" version="1">MVLPECFVDIPALPNIVSLSGTPVAALLAYAPTHTDYVGGTSCGLSSYVTTTPYTPYQRTSIATCSLPSSVSGKPYSVTPVVFITRTVSSTTRRTLYSCDPIPAASINKGNFDFACKSLLGKDVGAGIHSISWYLPTAAGISIWPYTFDVILPKSTPTYVINTALATTTLVPTTEVYVDATTSITRTVASTSTVTVPTATSTCFVTVTVTQVPGPRLRRTGVDANLKPDPASTVPDSAIVDADDNVGNSADAIVGLEQRASARPKIGKPDFTYPPYGVTTIYVTNMSTDIYTYLYVSTFYETAPDVTTTTTSCLVTTTSTITVTATPVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDF1</accession>
    <name>Q2HDF1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcriptional regulator Ngg1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_01753</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NGG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220974.1">
        <property type="nucleotide sequence ID" value="XM_001220973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDF1"/>
    <dbReference type="FunCoup" id="Q2HDF1">
        <property type="interactions" value="308"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HDF1"/>
    <dbReference type="GeneID" id="4386907"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01753"/>
    <dbReference type="eggNOG" id="KOG4191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016102_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HDF1"/>
    <dbReference type="OMA" id="DLSHMMA"/>
    <dbReference type="OrthoDB" id="1232at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019340">
        <property type="entry name" value="Histone_AcTrfase_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10198">
        <property type="entry name" value="Ada3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="382"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="491"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="641"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="418"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ93518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="667" mass="72293" checksum="77447C2C2B7E9B68" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDI1</accession>
    <name>Q2HDI1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_01723</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220944.1">
        <property type="nucleotide sequence ID" value="XM_001220943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDI1"/>
    <dbReference type="STRING" id="306901.Q2HDI1"/>
    <dbReference type="GeneID" id="4386912"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01723"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005646_3_0_1"/>
    <dbReference type="InParanoid" id="Q2HDI1"/>
    <dbReference type="OMA" id="FTFAKEH"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000091">
        <property type="entry name" value="NADPH oxidase (NoxA), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000029">
        <property type="entry name" value="NADPH oxidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF39">
        <property type="entry name" value="FAD-BINDING FR-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="9">
        <location>
            <begin position="240"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ93488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="553" mass="63942" checksum="DD162018965D28BE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDI3</accession>
    <name>Q2HDI3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_01721</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220942.1">
        <property type="nucleotide sequence ID" value="XM_001220941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDI3"/>
    <dbReference type="STRING" id="306901.Q2HDI3"/>
    <dbReference type="GeneID" id="4386910"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01721"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002833_1_2_1"/>
    <dbReference type="InParanoid" id="Q2HDI3"/>
    <dbReference type="OMA" id="NPMTYDF"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF228">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="3">
        <location>
            <begin position="12"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ93486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="345" mass="37524" checksum="09B04F2C00D0CAA7" modified="2006-03-21" version="1">MSSSSRKAHFMHTNAVYWPNFRVYNGDTPGQLNYGCINRVHYAFANVTADGGVFLSDEWADARAPCDGVQGALGSFMHLKQRYRHLQVVLSIGGGDSAETFPIVASSAVLRDNFARSARGLVEASGLDGIDSKFEISKTLIFPKSTLLIDSVVWEYPCTPEQGRDFLALVAAIRIHLPEDRYLLTATLPAVKPVLQNIDLRQTAEYLDTLNLTAYDFFGHWTHKSGHHAQLYAMNKDEPSGAAGVKDLMSSGVPGKKILLGIPLFGRSFLGVAGPGHKNRGAGGKDGSFEYNQLPRKGTKEQVDKRAVAAQCKGLGGLFYWSAPCDAKDSKRSLIATGFKALHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDX4</accession>
    <name>Q2HDX4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Elongin-A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220801.1">
        <property type="nucleotide sequence ID" value="XM_001220800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDX4"/>
    <dbReference type="STRING" id="306901.Q2HDX4"/>
    <dbReference type="GeneID" id="4387251"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01580"/>
    <dbReference type="eggNOG" id="ENOG502SF7P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_633131_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HDX4"/>
    <dbReference type="OMA" id="DCWYDVY"/>
    <dbReference type="OrthoDB" id="21513at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010684">
        <property type="entry name" value="RNA_pol_II_trans_fac_SIII_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47543">
        <property type="entry name" value="OS08G0169600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47543:SF2">
        <property type="entry name" value="RNA POLYMERASE II TRANSCRIPTION FACTOR SIII SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06881">
        <property type="entry name" value="Elongin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="47795" checksum="7B6BA3EF83F9AB53" modified="2006-03-21" version="1">MAQQRTLVETPLGPRLVVEVPLGARSLAEMSLKVAIDNVKMIQSLGDIPPCYLDPILQAVKSAEQLHIIEINSYDIYDETEKHWKRIIKKDFPILANRHDYVPQNRKSWHKIYNKYKQLDNEQLAAATEKLMQGFAVHTQEKQSRASTIISAEKGGKLRKTKAKSGFNTPRSDNSFISNTRAQLRREAFRFNRPTPSGQLPVRPNQIKKPPPAMVDDHRRMACGNSIPEPPPMIRTPRQRSAPNATGSAQNRKEGESRLLQIKNGGRPNTGPAKNVLSFSDDEGPNDSLPNDADLFGDADDDDLFGDLEQEKKASSAPSPQKSRPTPQPAPTQSSKRRRIVEDIDTEQPTKRPRGFETTTTSALPPPNKAPNQPLKPRPKGLSAAPGINQAPRKMPPGSALKAAAPSAAPPRRSFSAHTGFSQPPRGHPPPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HE22</accession>
    <name>Q2HE22_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_01532</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220753.1">
        <property type="nucleotide sequence ID" value="XM_001220752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HE22"/>
    <dbReference type="GeneID" id="4387941"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01532"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="InParanoid" id="Q2HE22"/>
    <dbReference type="OMA" id="DVYVMAI"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ93297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="51847" checksum="66C8B151A3764ADC" modified="2006-03-21" version="1">MDEKDTNNPPHALPPEPIINHDTSSDTDAPPPPSTTTTPATVTIITGTTPRTLHGARWFLVCVAIFSANLLYGLDTTIVADLQGRGLGNLRQRDPARVAGATLNLSTLLTSPKEQPFYVGLTGFVYGSGCVLGPVVGGALADSAATWRWAFYLNLCIFAAAAPVYIFLIPSLPRRPSPSFTSNLKSMDWLGTLLTAGLCSAFTVAFSFGGVLWAYSDGRTIALIVVWVTCTLAFGITQKYSILTTPLDRLFPGEFLRDPQLILLYIIMSQPCALLPFICLYVATILACGAVMGRTGYHAAWFLLSGLCLTAGAACMYAVRAHTPLAHIHGFGALLGLGMATSQAGYAVGNQLVRPARAAELIQFLNVSQAASQLIGLAIASAVFQTQAVGGMRAVLGPLGFGEKEIQTAVAGARSDVLQRVGPEVRAQCIDIIVHAISQCWLLVVAAGAVYTLCSLFLTRSRWIVRKSDEDGVVVGESSGGSREGLKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEZ3</accession>
    <name>Q2HEZ3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_01211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220432.1">
        <property type="nucleotide sequence ID" value="XM_001220431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEZ3"/>
    <dbReference type="GeneID" id="4387397"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01211"/>
    <dbReference type="eggNOG" id="ENOG502TCUE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060776_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HEZ3"/>
    <dbReference type="OMA" id="IEVQCSH"/>
    <dbReference type="OrthoDB" id="4926491at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ92976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="396" mass="44495" checksum="8D07A3DE7A6A5711" modified="2006-03-21" version="1">MQGKCRYGVVSAGCAELSHRRTLEAPFAKDLLCSWDRLVHTLYMCGRRQQPPSSGSSPLKQGANDSHRPLKAQVAIRDHWTKADSPVQTSLRELQELLGRTIVVEPEWRILVAELDTFYDDKTNLVTSVAGCVRAWARSMTELLDDEAHADWTEEVLVKTSGEMWVFVEVATSAKAATTWSEQRGGFVVSLPKKQVYQPAELFPTFRQDLLACFAKKDEPHPPQIREAGGADDWEGVEVNTSTGTPEVVEAPTRTVTLRPQAEFMPDVASLPRPDQLFLQPPYHLTLFQSSLLIELHGSHSPSLKFLAEYLKRWCRVNHADTRNPPGVQINLHQSAFGLGEVFDRLTLSTEETKYTNQFTVTAPMVVSLIEGILGYKLISTDGRWNFRRDTAFKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFI3</accession>
    <name>Q2HFI3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_01021</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220242.1">
        <property type="nucleotide sequence ID" value="XM_001220241.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HFI3"/>
    <dbReference type="GeneID" id="4387524"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01021"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_31_0_1"/>
    <dbReference type="InParanoid" id="Q2HFI3"/>
    <dbReference type="OMA" id="FAGAMFH"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="46"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="870"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1746"/>
            <end position="1823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="870"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1029"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1654"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1665"/>
            <end position="1675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ92786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1841" mass="197393" checksum="15FC0AF147EFCB00" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFM7</accession>
    <name>Q2HFM7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_00977</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220198.1">
        <property type="nucleotide sequence ID" value="XM_001220197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFM7"/>
    <dbReference type="FunCoup" id="Q2HFM7">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HFM7"/>
    <dbReference type="GeneID" id="4386820"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00977"/>
    <dbReference type="eggNOG" id="KOG0217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_3_1_1"/>
    <dbReference type="InParanoid" id="Q2HFM7"/>
    <dbReference type="OMA" id="LMICARS"/>
    <dbReference type="OrthoDB" id="2534523at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001238">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000010">
        <property type="entry name" value="DNA mismatch repair protein Msh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF34">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="8">
        <location>
            <begin position="725"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ92742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="863" mass="94166" checksum="1B6F6588D31F0C69" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFR3</accession>
    <name>Q2HFR3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220162.1">
        <property type="nucleotide sequence ID" value="XM_001220161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFR3"/>
    <dbReference type="GeneID" id="4387142"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00941"/>
    <dbReference type="HOGENOM" id="CLU_1970275_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HFR3"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="127" mass="13933" checksum="A657210B602CDA2C" modified="2006-03-21" version="1">MQGGGEPCLWDKNKKSAPAGGGPEVWSNATSSPWARGRRPCTRREAAAGEEGVQSPHGPLVPTAQNWSIHAYRRAGQAPNIFMFWPPWRLSFGPEITWDDPVVGSDTDLQSGDADRVNGLHIELSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFU0</accession>
    <name>Q2HFU0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_00914</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220135.1">
        <property type="nucleotide sequence ID" value="XM_001220134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFU0"/>
    <dbReference type="STRING" id="306901.Q2HFU0"/>
    <dbReference type="GeneID" id="4387469"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00914"/>
    <dbReference type="eggNOG" id="KOG4455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110781_4_0_1"/>
    <dbReference type="InParanoid" id="Q2HFU0"/>
    <dbReference type="OMA" id="YPGFLFY"/>
    <dbReference type="OrthoDB" id="16510at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ92679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="123" mass="13196" checksum="8E91791BF479E3D0" modified="2006-03-21" version="1">MPSEQELQIQISPIVQESLVHNSRVSSSLPPPARPPASLFGVSAGILGLESYAGFVFYVALSLLTSVLFYALRVAPTSLASGKAPLDTSRYFRGAYDFWAGGLMNGFAGFVLTWTLFYGLVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG06</accession>
    <name>Q2HG06_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_00848</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220069.1">
        <property type="nucleotide sequence ID" value="XM_001220068.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4388096"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00848"/>
    <dbReference type="eggNOG" id="ENOG502R6PM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_256650_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HG06"/>
    <dbReference type="OrthoDB" id="4590927at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="619"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1037"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1198"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1283"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="645"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="710"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1044"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1064"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1303"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1334"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1349"/>
            <end position="1366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ92613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1366" mass="149360" checksum="AECAA6EE0F051227" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG56</accession>
    <name>Q2HG56_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-1,3(4)-beta-glucanase</fullName>
            <ecNumber evidence="3">3.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_00798</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;3)- or (1-&gt;4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.</text>
            <dbReference type="EC" id="3.2.1.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.6" evidence="3"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220019.1">
        <property type="nucleotide sequence ID" value="XM_001220018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG56"/>
    <dbReference type="STRING" id="306901.Q2HG56"/>
    <dbReference type="GeneID" id="4386931"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00798"/>
    <dbReference type="eggNOG" id="ENOG502QUM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016972_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HG56"/>
    <dbReference type="OMA" id="FKNAYWL"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000114">
        <property type="entry name" value="Probable endo-1,3(4)-beta-glucanase NFIA_089530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209155" description="endo-1,3(4)-beta-glucanase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="8">
        <location>
            <begin position="28"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="370"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ92563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="398" mass="40459" checksum="F8D53943DB563BFF" modified="2006-03-21" version="1">MVRPTLGFAGLALTASSVRAAYNIVDNFDASNFFTEFDFFTAPDPTHGFVQYVDAATASRDGLAGYADGGVYLGVDYTNTTTTGRPSVRVTSKKAYTKGLFIADIAHMPAGAAGSSSCGLWPAFWMFGPNWPNSGEIDIIEGVNSQRSNAVTLHTGPGCSVSNAGSLASTKLVSTDCQGTAGCSQSTRAADNYGPGFNAAGGGLYALEWTDAAIKVWFFPRGTPLATQLASPQPNNNNNTSTSQPPDPTTFGTPLALFTGSSSGGCPLSQHFADHSLVFDTTFCGDWAGRVWDADRACAALAPTCEAFVGGNPEVFADAYWLVRGVRVFQEGGEGNGGSGVGVGVGVGGGAGVGVGVGVGAGAGAGAGAGAGAGAGAGNGQRRRVGRRGGMRARKWWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGM0</accession>
    <name>Q2HGM0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7962 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219855.1">
        <property type="nucleotide sequence ID" value="XM_001219854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGM0"/>
    <dbReference type="STRING" id="306901.Q2HGM0"/>
    <dbReference type="GeneID" id="4387135"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00634"/>
    <dbReference type="eggNOG" id="ENOG502S039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1421266_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGM0"/>
    <dbReference type="OMA" id="FVEGDEC"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058268">
        <property type="entry name" value="DUF7962"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25907">
        <property type="entry name" value="DUF7962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7962" evidence="1">
        <location>
            <begin position="2"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="191" mass="20167" checksum="F318EBDFE5A488AC" modified="2006-03-21" version="1">MALLEDTLLADGREWVLGGGGGGDGGGSEGARKGPTLADIEAVWVLHWMIGIPGALFDAGYVSAERFPRVYAWVARFQAAVGAAKAGVVVKGMSGEEAAVVLKGQREGVGYFEKEGEVDAADPIVKVYGLEKGSRVEVWPTDSGAGHRDQGCLVSLDAEEIVWETDAGVRVHAPRHGFRVRLARPVEEVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGQ5</accession>
    <name>Q2HGQ5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_00599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219820.1">
        <property type="nucleotide sequence ID" value="XM_001219819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGQ5"/>
    <dbReference type="GeneID" id="4387149"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00599"/>
    <dbReference type="HOGENOM" id="CLU_2512419_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGQ5"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ92364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="85" mass="8623" checksum="764E54ADC87F54A4" modified="2006-03-21" version="1">MLFRGAGPYHPVGLGLVAHAMQCRLAARPVLAAACQRVNVSMCQCVSVLLRELAAELGGCVEGSGVGWLCGCGVGGLAVGWARGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHD0</accession>
    <name>Q2HHD0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219595.1">
        <property type="nucleotide sequence ID" value="XM_001219594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHD0"/>
    <dbReference type="STRING" id="306901.Q2HHD0"/>
    <dbReference type="GeneID" id="4387862"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00374"/>
    <dbReference type="eggNOG" id="ENOG502TDGP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_863790_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHD0"/>
    <dbReference type="OMA" id="LAWNEQI"/>
    <dbReference type="OrthoDB" id="5430299at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="353" mass="40229" checksum="FDE83527D049975A" modified="2006-03-21" version="1">MEDWMQKSSRYESIAKEMLTQDYNTASVTLSREVRDPQDLQEFYDWIWAKSLTRRLEVLTAEEFVRQVDSMSFHSIKAREKLSDPMDTIVIPIGFDGPFIYRLVTFVSHLMSHLWGDVTAEQARLSESLMGPGFLGVNLTVNPRESSYDEPGNLSETSTRSVESADASADEPGFPFIQLGDLEYGERENGRQGPWEDGDEKQLSKLWAENSYGWRETGYGLVARLNPSGYADGIYIMMYDIDGKILLKYANYPDDYDDWDKEVTVITHSSRCLPITSHHGHGGRGRFWFAKLAPNLSSCGKDYQIVLTEKTEHPVELVRAKRSEDGRIVRNTSDKKIWPSATREESSTEESST</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHG6</accession>
    <name>Q2HHG6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase CHL1</fullName>
            <ecNumber evidence="17">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-dependent DNA helicase chl1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Chromosome loss protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18 19">DNA 5'-3' helicase CHL1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CHGG_00338</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="17"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219559.1">
        <property type="nucleotide sequence ID" value="XM_001219558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHG6"/>
    <dbReference type="FunCoup" id="Q2HHG6">
        <property type="interactions" value="847"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HHG6"/>
    <dbReference type="GeneID" id="4387702"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00338"/>
    <dbReference type="eggNOG" id="KOG1133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006515_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HHG6"/>
    <dbReference type="OMA" id="YANINSP"/>
    <dbReference type="OrthoDB" id="267079at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001372">
        <property type="entry name" value="ATP-dependent DNA helicase chl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="23">
        <location>
            <begin position="5"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="908"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="951"/>
            <end position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EAQ92103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="979" mass="105610" checksum="6B4FD0C9DF6F09FD" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHM2</accession>
    <name>Q2HHM2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_00282</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EAQ92047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001219502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHM2"/>
    <dbReference type="STRING" id="306901.Q2HHM2"/>
    <dbReference type="GeneID" id="4387956"/>
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    <dbReference type="HOGENOM" id="CLU_028200_0_2_1"/>
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    <dbReference type="OMA" id="ITNIFAC"/>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="27"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ92047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="294" mass="32388" checksum="5C0978C49C72591E" modified="2006-03-21" version="1">MGWTGEGPSLFAFSAGMLLFATLAVALRFVCRGYILRVLGLSDLCILFTLLFSLADTCILGIYASTGLELPKDSSELTSDEKQFVFKMLYASKLVVNFSVVMTKILVLLLFSRHLLDVLATVRRRTFLIVLTSVFGICDAITNIFACLPMSSFWNLDQPDHQCISIGDTKALADAVISCVLDAAIFCLPLPLIWPMTLPWRQKAWLYFAFALGFLVCAASAVRIYLVLGGVGIPSEENSLPYWVATEINVAIVIACIPTLRLLVVRIWPRLLETAAEDAKTSGNGRTSQPEQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHU1</accession>
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        <recommendedName>
            <fullName evidence="4">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">CHGG_00213</name>
    </gene>
    <organism evidence="5 6">
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        <name type="common">Soil fungus</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219434.1">
        <property type="nucleotide sequence ID" value="XM_001219433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHU1"/>
    <dbReference type="SMR" id="Q2HHU1"/>
    <dbReference type="STRING" id="306901.Q2HHU1"/>
    <dbReference type="GeneID" id="4387758"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00213"/>
    <dbReference type="eggNOG" id="ENOG502RM4B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_464594_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHU1"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ASP_PROTEASE"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="113"/>
            <end position="246"/>
        </location>
    </feature>
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        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ91978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="587" mass="63444" checksum="700227A674260708" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI71</accession>
    <name>Q2HI71_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_00083</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001219303.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4387623"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00083"/>
    <dbReference type="eggNOG" id="ENOG502SRUH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_262552_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HI71"/>
    <dbReference type="OMA" id="YANGFTY"/>
    <dbReference type="OrthoDB" id="5385013at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055795">
        <property type="entry name" value="DUF7371"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24086">
        <property type="entry name" value="DUF7371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208990" description="DUF7371 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7371" evidence="3">
        <location>
            <begin position="1292"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="882"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="945"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1154"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="554"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="594"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="653"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="892"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ91848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1422" mass="143784" checksum="51832E31900AB90B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM25</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226246.1">
        <property type="nucleotide sequence ID" value="XM_001226245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GM25"/>
    <dbReference type="GeneID" id="4397270"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10979"/>
    <dbReference type="HOGENOM" id="CLU_956456_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GM25"/>
    <dbReference type="OrthoDB" id="5233753at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ83161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="291" mass="32949" checksum="81212CFB7D4A9605" modified="2006-03-21" version="1">MLPLTLSQLLDDWEFDKYESTPKKARFALESHFDNMLAFDDEGDLWIDVGGGEAKAGDGGRQRPGLYRFRVCSQTLRRKSQGWDDVLSESYRKRKAEPDDGSKQEELVVVLPDHQPGAVAVLLAVIHNRLDMMPPSQNRIHSHYEAISAIPSVSDDYDVVHLFSPFVSAWVQCGRLPHYTRGMTYDYTTIVHRLNIAWQTGAVDLLKDAINHFLFRMTKVELDKLWDAANNTPTIAIFPTLLMFVEDLAAVRQKLIQSALRFYEQVTDGLRKNSTTGCKKAMFGAVDRAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMV9</accession>
    <name>Q2GMV9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_10695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228622.1">
        <property type="nucleotide sequence ID" value="XM_001228621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMV9"/>
    <dbReference type="GeneID" id="4396963"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10695"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_8_1"/>
    <dbReference type="InParanoid" id="Q2GMV9"/>
    <dbReference type="OMA" id="LATAIWC"/>
    <dbReference type="OrthoDB" id="2533084at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF187">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208397" description="Major facilitator superfamily (MFS) profile domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ84291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="42429" checksum="4D6C695754D97860" modified="2006-03-21" version="1">MLSAYFGRLPVVFWFLLVSTATAAWCAGATTFESFMAARILNGFFSTVSQAGGLMFLKDIFFFHEQARKINIWAPYMGPLLAAFITETQRWPVPFWVFFAMNVLGLGLVVCFLQETYYDRIIPIDEQPARGSRISRLTGVAQWKSRHLRNTFGQACWRTVIVLTKPTVAIACLFYALTFAWAVGINTTLAIFVTPLYGFAPRQVGFFYFTPVVAVILGESAGHWLHDALAKRYIRQHKGHFEPEARLRVVFFSMPFVIVGLVLIGQCFENAWHYMATSVCWGMYVFGMMITTVALSSYCLDSYPEASGEVSAWLNMARTVGGFIVSYFQVTWAEAQGTKLSFGIQAAVCAGAFLFIIILLRWGKAMRVWAGPLNFATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMW7</accession>
    <name>Q2GMW7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Tryptophan synthase</fullName>
            <ecNumber evidence="5 13">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_10687</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the TrpB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="5 13"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228614.1">
        <property type="nucleotide sequence ID" value="XM_001228613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMW7"/>
    <dbReference type="FunCoup" id="Q2GMW7">
        <property type="interactions" value="415"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GMW7"/>
    <dbReference type="GeneID" id="4396373"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10687"/>
    <dbReference type="eggNOG" id="KOG1395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016734_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GMW7"/>
    <dbReference type="OMA" id="VDTARHS"/>
    <dbReference type="OrthoDB" id="10050244at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000151">
        <property type="entry name" value="Tryptophan synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000001">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000004">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="14">
        <location>
            <begin position="350"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ84283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="697" mass="74765" checksum="57FA5E1F5A9949B9" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNC3</accession>
    <name>Q2GNC3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228458.1">
        <property type="nucleotide sequence ID" value="XM_001228457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNC3"/>
    <dbReference type="STRING" id="306901.Q2GNC3"/>
    <dbReference type="GeneID" id="4396753"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10531"/>
    <dbReference type="eggNOG" id="ENOG502RMXY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141170_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNC3"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004207973" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="16620" checksum="D6FC151449D7606C" modified="2006-03-21" version="1">MVGLMKLFASAALLAQGALAVPTELAKRGEGIHLFNCRPFGGAGVPQTWISIVVYCANDSDCSSLGYSPPSDNVCVKGTSTSSEVYHVWEGGSQSCTFPTGVTFTWNIPSGAQSQPNYSSVGSGSNGYRSFAGFKDDHVNGASYNYHSCEKIYYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GND7</accession>
    <name>Q2GND7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228444.1">
        <property type="nucleotide sequence ID" value="XM_001228443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GND7"/>
    <dbReference type="STRING" id="306901.Q2GND7"/>
    <dbReference type="GeneID" id="4396861"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10517"/>
    <dbReference type="eggNOG" id="ENOG502SKET">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2183652_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GND7"/>
    <dbReference type="OrthoDB" id="187522at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43264">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43264:SF1">
        <property type="entry name" value="INOSINE_URIDINE-PREFERRING NUCLEOSIDE HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208827" evidence="1">
        <location>
            <begin position="19"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="109" mass="12248" checksum="A42AB1212C5EF668" modified="2006-03-21" version="1">MKRLAVLYLSFIGSLALAAKKNLIIDTDLFSDVDWYFTLGEYASKVAYHFSGGSLRWGHAEDAWDPVELYRKVLSEAEDSSVTIVSIGFLDNVRPPPNHHSPKHPNTQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNJ4</accession>
    <name>Q2GNJ4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LsmAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_10460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228387.1">
        <property type="nucleotide sequence ID" value="XM_001228386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNJ4"/>
    <dbReference type="STRING" id="306901.Q2GNJ4"/>
    <dbReference type="GeneID" id="4396682"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10460"/>
    <dbReference type="eggNOG" id="KOG2375">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007072_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNJ4"/>
    <dbReference type="OMA" id="RMQMSAS"/>
    <dbReference type="OrthoDB" id="2275718at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="2">
        <location>
            <begin position="76"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="777"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="799"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="820" mass="88650" checksum="FA570AA22C281B04" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2025-04-09" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNY7</accession>
    <name>YPI1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Type 1 phosphatases regulator YPI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">YPI1</name>
        <name type="ORF">CHGG_10317</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YPI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228244.1">
        <property type="nucleotide sequence ID" value="XM_001228243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNY7"/>
    <dbReference type="SMR" id="Q2GNY7"/>
    <dbReference type="STRING" id="306901.Q2GNY7"/>
    <dbReference type="GeneID" id="4396593"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10317"/>
    <dbReference type="eggNOG" id="KOG4102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098333_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GNY7"/>
    <dbReference type="OMA" id="RRHIQWA"/>
    <dbReference type="OrthoDB" id="307488at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000333472" description="Type 1 phosphatases regulator YPI1">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="196" mass="20677" checksum="3091058E54F3EA36" modified="2006-03-21" version="1">MSSAAPRSQQRQQQRQPSRPAPSQTETTPSTTPQTHTQPQAILRLRGAHAPTGRSVQWRSDVVDNEGLGRKKSKVCCIYHRPRGVDESSDSSSSSSSDSSDSDSDADSDSGRASGSGKKTGDGNHKQGHAHDCDGHHSHRGSRGQGKARRKRRPSPNAYEKMPRYDKPGKDGDGDGSGGSGEGKGKGVPGQGPQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPG5</accession>
    <name>Q2GPG5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228066.1">
        <property type="nucleotide sequence ID" value="XM_001228065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPG5"/>
    <dbReference type="GeneID" id="4395985"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10139"/>
    <dbReference type="HOGENOM" id="CLU_1895961_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPG5"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="134" mass="13892" checksum="88D46CA7F42EFCB7" modified="2006-03-21" version="1">MDRDSHSTGTNSEALRRLTIISIRNVTRPPCPSQLYPVPENSAINEEMGQQYDAPGDTGRPQVHPGRPGTHPIDANGPGGPGDRCNESGDHPDATTGAPDHAGTPPENPSLSATPTNNPGAETTGPHFPDGTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPJ8</accession>
    <name>Q2GPJ8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aldose 1-epimerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_10106</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228033.1">
        <property type="nucleotide sequence ID" value="XM_001228032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPJ8"/>
    <dbReference type="STRING" id="306901.Q2GPJ8"/>
    <dbReference type="GeneID" id="4396569"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10106"/>
    <dbReference type="eggNOG" id="KOG1604">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031753_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GPJ8"/>
    <dbReference type="OMA" id="HWESSWE"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000014">
        <property type="entry name" value="Aldose 1-epimerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF2">
        <property type="entry name" value="ALDOSE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ83702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="42315" checksum="33DF841F9AFB4647" modified="2006-03-21" version="1">MKFSLPFLVAAVEAAVIGRSCEGPKPDEDGRYTISSDGIKAQAQFIPYGATLTNLFVKDKNGEDIDVVLGYDDVEYYPVDPGHPVYNAIPGRYANRIGNGKYTLDGVEYETEQNDGNNTLHSGTNNWSYRVWNVTDFKADSITFSILDPSNSSQGMPGDVKASVTYSVKGSTWNIKMTAESLEQKTPLLLTQHTYFNLDAFRNPDTSKIWDHTLYAPYSKRYLEADQAALPTGEILTAAPNSINDFASAPGLTVGHARDQPGFEGNCGADGACEGYNGYWLIEDAPKDAVVVTLASKFSGVKAELRTDQPGVVLYSCNWMDGSADLKSTQGIEGVNEKVIRSSCIAIEAQDYPDGINHPEWERTDAQIWGPGETYNWESSWTFGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPL3</accession>
    <name>Q2GPL3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228018.1">
        <property type="nucleotide sequence ID" value="XM_001228017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPL3"/>
    <dbReference type="GeneID" id="4396642"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10091"/>
    <dbReference type="HOGENOM" id="CLU_3335510_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPL3"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ83687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="38" mass="3655" checksum="4C4D0D1DE483313B" modified="2006-03-21" version="1">MVVLPQNGAPCNPAADSLLQAAPCRGCGAPTGDAGPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQ61</accession>
    <name>Q2GQ61_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Infection structure specific protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_09893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227820.1">
        <property type="nucleotide sequence ID" value="XM_001227819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQ61"/>
    <dbReference type="GeneID" id="4396782"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09893"/>
    <dbReference type="eggNOG" id="ENOG502RJDB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076156_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQ61"/>
    <dbReference type="OMA" id="RQFRTTD"/>
    <dbReference type="OrthoDB" id="4589961at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208055" description="Infection structure specific protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ83489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="27954" checksum="6306BDE6C6C236B2" modified="2006-03-21" version="1">MHTTTTLLAALTSATLALANPAPAAEAHPALVTAAPALHPAAARLAARQFRTTDSEISKSIACGSAYLSLAGDAPRETNAALARWVLSAASPAAEIVTATALDESLTSLCDPSLTATLTPPASLSSAWSTYLEKASSWMTSAAPEASSLAQSCGGEIGAVIGFLVVSDAESCTKAVLDLVAAANGEDVTSASDSETVSPTRSRTTAAPEASETGSAGGDDDNGDGGDDGADNGNGGGEDGGSDNGSDETGGAGAAETSSTSTGGVPRETGFVGVAAAAAVAVVGVVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQC3</accession>
    <name>Q2GQC3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_09831</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227758.1">
        <property type="nucleotide sequence ID" value="XM_001227757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQC3"/>
    <dbReference type="STRING" id="306901.Q2GQC3"/>
    <dbReference type="GeneID" id="4396818"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09831"/>
    <dbReference type="eggNOG" id="ENOG502RZQZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068085_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQC3"/>
    <dbReference type="OMA" id="DDYLCVF"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF146">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ83427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="331" mass="35113" checksum="A801D5230FD02B25" modified="2006-03-21" version="1">MSMPAATSDTSGILAAGITLSVFTTGIVTVRLAANLHQTGKLQADDSEGEGFADLDPRPAIRRVAQYAEAGIFLSGFSLWTAKLPVLVLLARIFGIYRGVRISSIITAIVLGMAVIGADIYNAVICWPPSIDDDPAVFLGYVAKCTEASSLTGVILAPIGLAADIIIFILPIPVILRLQLSTEKKIGLVVVFLFGLVAIAGTAVAMKFKIDSRSGHATDVQVAMILTLLETTIVIAAGCVPAVKAFWAGFIIGSGWYSRLTSLLSTSGRNTSRGTGRSTKQSQDSLQRDGSSTENFNDYYQLEEQNSVGKWPHAVAHPYHVGVSGGQPPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQU9</accession>
    <name>Q2GQU9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Carrier protein YMC1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_09655</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227582.1">
        <property type="nucleotide sequence ID" value="XM_001227581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQU9"/>
    <dbReference type="FunCoup" id="Q2GQU9">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="GeneID" id="4396422"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09655"/>
    <dbReference type="eggNOG" id="KOG0758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_16_2_1"/>
    <dbReference type="InParanoid" id="Q2GQU9"/>
    <dbReference type="OMA" id="VWFLAFE"/>
    <dbReference type="OrthoDB" id="409586at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="23"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="117"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="224"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ83251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="33514" checksum="7EA94360B3C06F0E" modified="2006-03-21" version="1">MADSAADVEAHDAAAPSSGLQTAKDLFSGAAGGIAQVLIGQPFDIVKVRLQTSQAYPSALAAATSIYRHEGALAFYKGTLTPLLGIGACVSIQFGAFHAARRWLEDRRGPAARGTPLGYGEYYAAGAFAGLANSFLSGPIEHVRIRLQTQPHGAGRLYAGPWDCVRKLCSAAPGGGGGVARGLYRGEAVTLLREAQAYGVWFLAFEWLMNSDAERNKVQRKDIASWKVAFYGGLAGEALWLGSYPFDVVKSKMQTDGFGAEQRYKTMRDCFAQTFRAEGLRGFWKGIGPTLLRAMPVSAGTFAVVEMTMRAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSF5</accession>
    <name>Q2GSF5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227026.1">
        <property type="nucleotide sequence ID" value="XM_001227025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSF5"/>
    <dbReference type="GeneID" id="4395234"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09099"/>
    <dbReference type="eggNOG" id="ENOG502SD7X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054588_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSF5"/>
    <dbReference type="OMA" id="DIVLLRM"/>
    <dbReference type="OrthoDB" id="5378679at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="363" mass="39709" checksum="C0F4F30E30145362" modified="2006-03-21" version="1">MLRIMANKILIFSGAPDSNSLDWHTGGLLSGFQDTIAQFTGLTTETGLHPTTSPAPDHAAWRSLSLDKATIPTGFSQQYDRGVYYGPEESAFGSSPEFLATVSLSFDSDADDGEQNSILSQFYEHSVVIHEELSSSQLISQSTGQSTSLLSDSTSFLSGNGSQPGSTKGPVLFRGSDLIGDLRSIPSAAYLLKIHPQTMTYNLIVGIISISQPRAVKTRWGATKYLVEVLVGDETKAGFAITYWLPYDSVEDSPLGGMRPRDVVLIQNVAFNVFMKKVYGSSLRKDLTRVHLLYRVKLDPQDTGGYYTTSDLSSAGGAHPQLAKTRRVRDWVLNFVGRGSHNRAKPDPRPRWDKPPDDDTQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSN2</accession>
    <name>Q2GSN2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226949.1">
        <property type="nucleotide sequence ID" value="XM_001226948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSN2"/>
    <dbReference type="GeneID" id="4394944"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09022"/>
    <dbReference type="eggNOG" id="ENOG502RKID">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1937920_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSN2"/>
    <dbReference type="OMA" id="ESWMWIT"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="130" mass="14553" checksum="A7546073B365E41C" modified="2006-03-21" version="1">MSTAFRPPTINRLQRLLTIPILPSRRLLLPRQTTTTSPFSTSRAVHNKPNTTTTNTKSSSNTNANNVDTTASGNPSYPTFNLRSIVPNPRVRRALMAVLGVMVVAESWMWITYWPRIVGWWKGEEGGAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU10</accession>
    <name>Q2GU10_CHAGB</name>
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        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226471.1">
        <property type="nucleotide sequence ID" value="XM_001226470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GU10"/>
    <dbReference type="STRING" id="306901.Q2GU10"/>
    <dbReference type="GeneID" id="4395414"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08544"/>
    <dbReference type="HOGENOM" id="CLU_148835_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GU10"/>
    <dbReference type="OMA" id="YASECGY"/>
    <dbReference type="OrthoDB" id="5279542at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="16449" checksum="8A4AF598463DF6B2" modified="2006-03-21" version="1">MSEEMEPTKPPPAHVSPTGMWASKLTLRVIQFALAITIIGCVGSILSTGFYSIFVLVVIVPQAAVSVIWSLVEGICILVRGGRRGIHPGANVGFDLLLWLGLVVGTIFMWLFGVDSELNVGSSSYNYGDNYDSALAVILKVAGLGQALIGLGATLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU18</accession>
    <name>Q2GU18_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_08536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226463.1">
        <property type="nucleotide sequence ID" value="XM_001226462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GU18"/>
    <dbReference type="GeneID" id="4395438"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08536"/>
    <dbReference type="HOGENOM" id="CLU_1786627_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GU18"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="145" mass="16695" checksum="4BF007701BC894FE" modified="2006-03-21" version="1">MGLRPISRGTEGTATVPRIQYGTRGTITVPHVPSKSKLESLRRFPLHKHADLLKDQIPTVEHLQGLAARELDGGQQVFVAGNEFWVKVVEAEPEKWNMRPGLSDCFRVPVGLLEEYWFQRERAHPAREMLWKEDQRFPSELFFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU38</accession>
    <name>Q2GU38_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226443.1">
        <property type="nucleotide sequence ID" value="XM_001226442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GU38"/>
    <dbReference type="STRING" id="306901.Q2GU38"/>
    <dbReference type="GeneID" id="4395122"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08516"/>
    <dbReference type="eggNOG" id="ENOG502RWEH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011082_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GU38"/>
    <dbReference type="OrthoDB" id="2624308at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="524"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="566"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="683"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="836" mass="93222" checksum="06DBA6B5C0A03E3A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUD8</accession>
    <name>Q2GUD8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_08416</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226343.1">
        <property type="nucleotide sequence ID" value="XM_001226342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUD8"/>
    <dbReference type="STRING" id="306901.Q2GUD8"/>
    <dbReference type="GeneID" id="4395135"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08416"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GUD8"/>
    <dbReference type="OMA" id="SRKIDSC"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="7"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ84402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="244" mass="24964" checksum="01285D68D30E85AA" modified="2006-03-21" version="1">MTRLNGKTAVITGGATGIGLAAAKRFTEEGAFVFIFGRRQEALDAAVADLGPNARAVKGSVSNLADLDRLYAAVKSERGTLDIVFANAGTGSPLPLGQITTEHVDEIFDTNVKGSIFTVQKALPLMGKGGSIILTGSSSGTTGFPAFSAYAASKAAVRNLARTWAEDLKGTGIRVNVLSPGPTATELAVEALGEEGMKAVAELNPLRRMADTAEIGAVAAFLASQDSSFMTGSEVAVDGGIAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUL3</accession>
    <name>Q2GUL3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polysaccharide lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2005-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Giovannoni S.J."/>
                <person name="Cho J.-C."/>
                <person name="Ferriera S."/>
                <person name="Johnson J."/>
                <person name="Kravitz S."/>
                <person name="Halpern A."/>
                <person name="Remington K."/>
                <person name="Beeson K."/>
                <person name="Tran B."/>
                <person name="Rogers Y.-H."/>
                <person name="Friedman R."/>
                <person name="Venter J.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 148.51</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2006-02" db="EMBL/GenBank/DDBJ databases">
            <title>Annotation of the Chaetomium globosum CBS 148.51 Genome.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Birren B."/>
                <person name="Lander E."/>
                <person name="Galagan J."/>
                <person name="Devon K."/>
                <person name="Nusbaum C."/>
                <person name="Ma L.-J."/>
                <person name="Jaffe D."/>
                <person name="Butler J."/>
                <person name="Alvarez P."/>
                <person name="Gnerre S."/>
                <person name="Grabherr M."/>
                <person name="Kleber M."/>
                <person name="Mauceli E."/>
                <person name="Brockman W."/>
                <person name="Rounsley S."/>
                <person name="Young S."/>
                <person name="LaButti K."/>
                <person name="Pushparaj V."/>
                <person name="DeCaprio D."/>
                <person name="Crawford M."/>
                <person name="Koehrsen M."/>
                <person name="Engels R."/>
                <person name="Montgomery P."/>
                <person name="Pearson M."/>
                <person name="Howarth C."/>
                <person name="Kodira C."/>
                <person name="Yandava C."/>
                <person name="Zeng Q."/>
                <person name="Alvarado L."/>
                <person name="Oleary S."/>
                <person name="Untereiner W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 148.51</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226268.1">
        <property type="nucleotide sequence ID" value="XM_001226267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUL3"/>
    <dbReference type="CAZy" id="PL20">
        <property type="family name" value="Polysaccharide Lyase Family 20"/>
    </dbReference>
    <dbReference type="GeneID" id="4394780"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08341"/>
    <dbReference type="eggNOG" id="ENOG502SKY0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090719_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUL3"/>
    <dbReference type="OMA" id="CDDYMPS"/>
    <dbReference type="OrthoDB" id="3889489at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025975">
        <property type="entry name" value="Polysacc_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14099">
        <property type="entry name" value="Polysacc_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208643" description="Polysaccharide lyase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="28600" checksum="66B771DC08CEC4E8" modified="2006-03-21" version="1">MVLPIILSVLLTAWPAVRAEQIFNNRGTLTGWGGTQTEHNGEIKEVTDVFLDEPPALVMTQTFDESYTGRYHSEVRVLNAYKHGDTRFYGFAFRLPPDWQFDPAQSYDLAQFIAPFDKCDTFMPTTMFWAEGTKLFTRLKSGSVCDQKTKELPLDVTLTAGEWHKVMIQARWESEATGFLRLWFDDKKVLDEQNVATTVSEDVPFQFRVGLYANGWHDDKGMKGTQGFRQVFYDKVAIATTKEEADPALW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUL6</accession>
    <name>Q2GUL6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Regulatory P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226265.1">
        <property type="nucleotide sequence ID" value="XM_001226264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUL6"/>
    <dbReference type="STRING" id="306901.Q2GUL6"/>
    <dbReference type="GeneID" id="4394777"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08338"/>
    <dbReference type="eggNOG" id="ENOG502QQSB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031217_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUL6"/>
    <dbReference type="OMA" id="RRGIDHN"/>
    <dbReference type="OrthoDB" id="2099887at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027589">
        <property type="entry name" value="Choice_anch_B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04312">
        <property type="entry name" value="choice_anch_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38787">
        <property type="entry name" value="REGULATORY P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38787:SF3">
        <property type="entry name" value="REGULATORY P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208640" description="Regulatory P domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="53098" checksum="6622BE4DFC8C019C" modified="2006-03-21" version="1">MAPLHIGTLVTGLVALSSAKELVVDMKLKTELYDPGLVHGRIMATKERQWGEMARQAVFDSTQYATFSEETDRIACVDGTAALVPGDPNNTFRCQGLDLLDFKTHAQLGSSSGRGAGSWGWTSAEGREFVAIAQEDGTAFAEVNARGKLIYLGRLPQYDGAPISLWREIKGYKSYILIGSEAERHGIQIFDLSKLLDVDSSSPVVFNNQEDLTGFWAEGLPLGRSHNVVTNEELNYGVATGFQPRDGPLGAGLVFFDLTDPSNPRTLGGTGADGYVHDAQCIVYRGPDTKYDGRDICYGYDEDSLTIFDVSDKENIKVISNTSYEGFVYTHQGWVLDPQWQQYLITDDEYDEFDKSGLAADGYPISYIWDISSLESPKQTGHYKGLRKGIDHNQFVKDGFSYQSNYGLGLSILDLRSVSSDPTGKGIIEVAFFDTHPEDDHLPGGGNVTFTGSWSHYPFFPSGVIVINTMDRGAFVVKRSAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUP3</accession>
    <name>Q2GUP3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3'(2'),5'-bisphosphate nucleotidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_08311</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ87058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225967.1">
        <property type="nucleotide sequence ID" value="XM_001225966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUP3"/>
    <dbReference type="STRING" id="306901.Q2GUP3"/>
    <dbReference type="GeneID" id="4394155"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08311"/>
    <dbReference type="eggNOG" id="KOG1528">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033446_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GUP3"/>
    <dbReference type="OMA" id="EGCIFFA"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF2">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ87058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="45155" checksum="53D691025A776645" modified="2006-03-21" version="1">MQAKVGLEQYMSSSGAPIVERGCLGWSLGELRARGPSRTSRSGTGDKCDRNQQDHLAVMDSPYRHELEVALAVAQTAARISREVLAAAQADATPGTFDLVKDDLSPVTVADFAIQALLTRTLRNAFPDDGFIGEESADELRQNPRLASLVLAIIAQCAGDTLFRDADDLCDVIDSCTTLTPGPGRIWVFDPIDGTKTFIRREQYAINIALLETGRQVLSVVACPLLSVDVTPPVTDGTVDPTGKGCVLYALRGHGAHIRPLLGDHGEAQARRLPRHADDATSTSDLRSVTCWALLDSGVDVVHKGVAELLHVPFPGNDLLGWVPRWAVLAVGAANMTVWVYKKRDRYAKIWDHAGAMLLFEEVGGLITDVHGKEIDLTAGRKLEANFGFVAAPRSLHHIVLRAVHDTLKASGKEALLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUT5</accession>
    <name>Q2GUT5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ87016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225925.1">
        <property type="nucleotide sequence ID" value="XM_001225924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUT5"/>
    <dbReference type="STRING" id="306901.Q2GUT5"/>
    <dbReference type="GeneID" id="4394194"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08269"/>
    <dbReference type="eggNOG" id="ENOG502S0C8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_341942_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUT5"/>
    <dbReference type="OrthoDB" id="4314040at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF13">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="829" mass="91787" checksum="E13B45B151119718" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV52</accession>
    <name>Q2GV52_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225808.1">
        <property type="nucleotide sequence ID" value="XM_001225807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV52"/>
    <dbReference type="GeneID" id="4393771"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08152"/>
    <dbReference type="HOGENOM" id="CLU_626989_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GV52"/>
    <dbReference type="OrthoDB" id="10461741at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="437" mass="47271" checksum="98E8C48B664F507B" modified="2006-03-21" version="1">MDEGLARCEGCVRYHGSSVSTGCLGLAISANSCVAAGTYVHRMRCISGACSFPSPLFIIPPSPTQTQTQTQTQTQPQVTYFPAPTPTPIFRSPPPNPPTLYAPKLKPNPDAGLLSSNSTSTITTSSLLLPLSDIPPTMRCSSLFLPARGPSPSPEMLAVAGWCRDKEWRQERSDGGGGGGGAKEAREEAGHGVLEDGKAGADDAEVGFEEGPYDAVDEMAAMTKTPQSSKRSRKLRCSFRMGQTGNTSTKTSVVMFKTAYAIQDFSESMQVAPESRTHAPWIGAHSKMVAAMLPMLYPTMTDKRVKAAERKFLDTNMRRHSKMTETLLRHTVTLYGVRAIKYHFRAPSTSARAGNQDGDQRGDVQLPALIFGPTVGEGDSTVAHPRLWECGLSLRVLGLPGLRRVHDLQSQIGLSRAPPGPWDGVRRDMSLKRRQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GW01</accession>
    <name>Q2GW01_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_07853</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225509.1">
        <property type="nucleotide sequence ID" value="XM_001225508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GW01"/>
    <dbReference type="FunCoup" id="Q2GW01">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GW01"/>
    <dbReference type="GeneID" id="4393930"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07853"/>
    <dbReference type="eggNOG" id="KOG2049">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004133_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GW01"/>
    <dbReference type="OMA" id="HYKGELY"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000237">
        <property type="entry name" value="Pumilio homolog 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF13">
        <property type="entry name" value="PUMILIO HOMOLOGY DOMAIN FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="570"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="632"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="668"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="705"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="741"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="777"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="813"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="849"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="242"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="445"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="976"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="70"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="320"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ86600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1010" mass="110601" checksum="2EB8F8CC9BFAC4C2" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GW19</accession>
    <name>Q2GW19_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225491.1">
        <property type="nucleotide sequence ID" value="XM_001225490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GW19"/>
    <dbReference type="GeneID" id="4393162"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07835"/>
    <dbReference type="HOGENOM" id="CLU_1194773_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GW19"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="232" mass="23808" checksum="B9B6CC8AADA4C933" modified="2006-03-21" version="1">MLLILKPVTPALILTHSRPHPRPNPHPHPRHAVPLPLRPAAHTPAGASACARAPSGPARYSSMTCAMIPEPIATRDAYSGQVVSGSGVGVVLASEVGGELGGGNAEVPGSSCLPGFGVHSEALAALVVELDDEVGVTVEGQVGYCIHKVVAIKFPGLDSSNTKRGIVLGPKNKRGSYSGSSQRSSALQHHCQPTNGPVRGVAWAGSYLDDAGRSGSNHFFCHAVSLSLKSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWC6</accession>
    <name>Q2GWC6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_07728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225384.1">
        <property type="nucleotide sequence ID" value="XM_001225383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWC6"/>
    <dbReference type="GeneID" id="4393360"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07728"/>
    <dbReference type="HOGENOM" id="CLU_1272134_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWC6"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ86475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="217" mass="23442" checksum="A16B088EEEDBFAE6" modified="2006-03-21" version="1">MTRQGLSFDSSTPVLWPRHMTDPSRFEVKANMLPQTGADISIPNINRLQECPEPRSGFPLDLQCDHGPAVSVPLAALSHAPDYHWARAHVGADDALSARTTAVVLVTGTAQNIRNPRQASYLGRAASSAGSPNGRSAGTESRIGAAVPILVGFPSISRRQAVCLPRPVRKPELNAYTAVIDKATQRSNCFSRPSRQRAEQSKKRASLRVIPAFSVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWQ8</accession>
    <name>Q2GWQ8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal RNA-processing protein 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_07596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225252.1">
        <property type="nucleotide sequence ID" value="XM_001225251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWQ8"/>
    <dbReference type="FunCoup" id="Q2GWQ8">
        <property type="interactions" value="305"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GWQ8"/>
    <dbReference type="GeneID" id="4393736"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07596"/>
    <dbReference type="eggNOG" id="KOG2974">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058264_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GWQ8"/>
    <dbReference type="OMA" id="FVKQRFY"/>
    <dbReference type="OrthoDB" id="20949at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012459">
        <property type="entry name" value="Rrp15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245:SF14">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07890">
        <property type="entry name" value="Rrp15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ86343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="34520" checksum="C63BA46CBD1A8526" modified="2006-03-21" version="1">MAGSSIKKRSISDGPKSRAARPTKKQRKIAAYHSSSEESGSDDENAPVPANLLDSDDEDLDNIEVDDGASSAGSASDSNSQSEAETAPKPKPFVARDAPASPNSAGSKEDHSSDDGDQDEFSDAASHSDDDSATESRRGGNDTRSKRNDPAAFATSISKMLASKLPASRRADPIVARSAAAAEQSRQAVDAALEAKARKRLREQKRLAMEKGRVRDVLVASTARTLNVATGEIEEVPDVAPGEAATTGEILAAEKRLRKVAQRGVVKLFNAVRAAQVKATEAERAARKEGVVGVDRKQEKVTEMSRKGFLDLIASGGGGLKKGGLEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXR2</accession>
    <name>Q2GXR2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_07242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224898.1">
        <property type="nucleotide sequence ID" value="XM_001224897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXR2"/>
    <dbReference type="STRING" id="306901.Q2GXR2"/>
    <dbReference type="GeneID" id="4393471"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07242"/>
    <dbReference type="eggNOG" id="KOG4368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021915_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GXR2"/>
    <dbReference type="OMA" id="NYQGQWP"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323:SF0">
        <property type="entry name" value="CALCIUM HOMEOSTASIS ENDOPLASMIC RETICULUM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323">
        <property type="entry name" value="SR-RELATED CTD ASSOCIATED FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="25"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ85989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="636" mass="69852" checksum="FA366DDDA4EB0FB6" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXR3</accession>
    <name>Q2GXR3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_07241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatase 2A regulatory subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224897.1">
        <property type="nucleotide sequence ID" value="XM_001224896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXR3"/>
    <dbReference type="FunCoup" id="Q2GXR3">
        <property type="interactions" value="586"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GXR3"/>
    <dbReference type="GeneID" id="4393470"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07241"/>
    <dbReference type="eggNOG" id="KOG2085">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012437_1_2_1"/>
    <dbReference type="InParanoid" id="Q2GXR3"/>
    <dbReference type="OMA" id="VHRWIDL"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070199">
        <property type="term" value="P:establishment of protein localization to chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031107">
        <property type="term" value="P:septin ring disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031134">
        <property type="term" value="P:sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="526"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ85988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="591" mass="66112" checksum="CA0E0A6987ACF816" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYF7</accession>
    <name>Q2GYF7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_06997</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224653.1">
        <property type="nucleotide sequence ID" value="XM_001224652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYF7"/>
    <dbReference type="STRING" id="306901.Q2GYF7"/>
    <dbReference type="GeneID" id="4394109"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06997"/>
    <dbReference type="eggNOG" id="KOG0764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1266891_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYF7"/>
    <dbReference type="OMA" id="HEYMEGM"/>
    <dbReference type="OrthoDB" id="10266426at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF1">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06780)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="55"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ85744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="20966" checksum="D384B40B6866DB02" modified="2006-03-21" version="1">MYTTEGILSFYSGLTPALLGLTHVAVQFPAYEYLKVKFTGRGMGAAPEAGQDDKAHWFGILSASIMSKILASSATYPHEVIRTRLQTQRRPMPGHEYMEGMGPVQPGVNGASQQPQAGPKYKGIVSTVRTMLREEGWRAFYAGLGTNMMRAVPAATVTMLTYEYVMRHLNHVRLDGREKLQLLKGEFPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYS9</accession>
    <name>Q2GYS9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase M16 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_06875</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224531.1">
        <property type="nucleotide sequence ID" value="XM_001224530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYS9"/>
    <dbReference type="STRING" id="306901.Q2GYS9"/>
    <dbReference type="MEROPS" id="M16.020"/>
    <dbReference type="GeneID" id="4394034"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06875"/>
    <dbReference type="eggNOG" id="KOG0959">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_705970_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYS9"/>
    <dbReference type="OMA" id="CHTASTE"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="8">
        <location>
            <begin position="72"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="9">
        <location>
            <begin position="211"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ85622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="43977" checksum="9DAD8D18695EF982" modified="2006-03-21" version="1">MSSAPVDVGGGSDGSGWSTNTARSIAHSTNPPKFNAWKRSTRDALVFKRPRCRYRTSSCPNHSRRRTTTSSRLLFMGNKKFPDEHEYKRYISNHSGSANAYTMANSTNFHFEVSAKPDNGEAPSVTNPSPLLGALDRFAQFFIGPLFLKDTLDRELLAVNSEHQNNLQSDRRRLAQLEKCLSNPKDPFCHFSSGNLETLKIAPEAQGINVRDKFIDFYEKHYSANRMKLCVLGQEPLDILQTWVIEHFSAVKNKNLAANRCEEALFTEEQLGIQIFAKPVMDIRTLTLTFLFIEQEYLYESQPGQYISHLIHHEGPRSIISHLKSKGWANELSATARPISPGSPNIFACDISLTEEFGPTLIKEGLDCLRPDNFCVTNLLQDPVLLGFSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZ35</accession>
    <name>Q2GZ35_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_05211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224425.1">
        <property type="nucleotide sequence ID" value="XM_001224424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZ35"/>
    <dbReference type="STRING" id="306901.Q2GZ35"/>
    <dbReference type="GeneID" id="4391849"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05211"/>
    <dbReference type="eggNOG" id="KOG3720">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023111_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GZ35"/>
    <dbReference type="OMA" id="REWAQAC"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF142">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208619" description="Acid phosphatase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ88592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="51526" checksum="A4A937BD6B6810CF" modified="2006-03-21" version="1">MHTSAMALAGLAATAAAETIHGALVFTRHGDRTTKHFGSQVLTPLGAQQVFQVGSDYRARYLDSSSPHHIQGISETEYVPAQIYASAPDQPILLNTATSFLQALYPPLGDTVSAQDLANGSSVASPLTGYQYVTLHGINDDSPETVWIKGDDDCPAVTAASADFKQSSEYQSRLAATRDFYQSLYPLVHEVYPSASDLSYAKAYDIFDVINVEKIHNASSPAQAVTPAQLNQLRTLADSAEFGLNYNASQPARSLHAGTLAGAVLNHLNQTAAATTTPSSSAPKLTVLAGSYDTFLAFFGRARLTEVSAQFFGLPEYASTMAFELFTPGDGSDDATDLHVRFLFRNGTVGRLQQFPLFGSGKADLPWGEFVEEMQLIGVSSAEQWCGLCRSEAVFCAAYRGGDWDGDGVYGLTGGDRGLVVGRGSWVAVLVVMAVAIAGNLVWAAMWLVRSRRAKKERMAATAAAAAVGRGSESVKSYDKESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZ45</accession>
    <name>Q2GZ45_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">xylan 1,4-beta-xylosidase</fullName>
            <ecNumber evidence="11">3.2.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_05201</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Hydrolysis of (1-&gt;4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini.</text>
            <dbReference type="EC" id="3.2.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="11"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224415.1">
        <property type="nucleotide sequence ID" value="XM_001224414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZ45"/>
    <dbReference type="STRING" id="306901.Q2GZ45"/>
    <dbReference type="GeneID" id="4391932"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05201"/>
    <dbReference type="eggNOG" id="ENOG502QQ55">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_5_3_1"/>
    <dbReference type="InParanoid" id="Q2GZ45"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF3">
        <property type="entry name" value="BETA-D-XYLOSIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208764" description="xylan 1,4-beta-xylosidase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="13">
        <location>
            <begin position="644"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ88582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="735" mass="79312" checksum="DB7B38DDEEBF36F2" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZL4</accession>
    <name>Q2GZL4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Alternative oxidase</fullName>
            <ecNumber evidence="17">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_05032</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 17">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="16 17">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the alternative oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="17"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224246.1">
        <property type="nucleotide sequence ID" value="XM_001224245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZL4"/>
    <dbReference type="STRING" id="306901.Q2GZL4"/>
    <dbReference type="GeneID" id="4391829"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05032"/>
    <dbReference type="eggNOG" id="ENOG502QSB5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041974_3_0_1"/>
    <dbReference type="InParanoid" id="Q2GZL4"/>
    <dbReference type="OMA" id="VHTYTRA"/>
    <dbReference type="OrthoDB" id="16906at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098803">
        <property type="term" value="C:respiratory chain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009916">
        <property type="term" value="F:alternative oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01053">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.140:FF:000002">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.140">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002680">
        <property type="entry name" value="AOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038659">
        <property type="entry name" value="AOX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803:SF3">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01786">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005229">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="16">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005229-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ88413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="368" mass="41797" checksum="8565D66A8DB84577" modified="2006-03-21" version="1">MISFEASKKICSPKQAAQLSRAVAPFFYQAHAVGLGYPATVRLAAITRQSRISLQPTPSGKRSFSTTSVNQLRDVFPAKDTPFIRKTPPAWEHPGYTEEEMLAVVPGHRSPETVGDWVAWKLVRLARWATDIATGIGREQQVDMKNPTTAVAAEKPLTEAQWLVRVIFLESIAGVPGMVGGMLRHLHSLRRLKRDNGWIETLLEESFNERMHLMTLMKMAEVGWFMKTMILGAQGVFFNAMFLSYLVSPKITHRFVGYLEEEAVHTYTRLLREIEQGDLPKWSDPAFQIPEIAITYWRMPEGKRTMKDLILYIRADEAVHRGVNHTLSNLKQKEDPNPFVSEYRVGEEKHKPKAALKPAGYERRDVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZQ7</accession>
    <name>Q2GZQ7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Phosphomevalonate kinase</fullName>
            <ecNumber evidence="3 15">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_04989</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP</text>
            <dbReference type="Rhea" id="RHEA:16341"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:16342"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="3 15"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224203.1">
        <property type="nucleotide sequence ID" value="XM_001224202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZQ7"/>
    <dbReference type="FunCoup" id="Q2GZQ7">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GZQ7"/>
    <dbReference type="GeneID" id="4392354"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04989"/>
    <dbReference type="eggNOG" id="KOG4519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022059_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GZQ7"/>
    <dbReference type="OMA" id="LVIHRTM"/>
    <dbReference type="OrthoDB" id="10262935at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016005">
        <property type="entry name" value="Erg8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035102">
        <property type="entry name" value="Phosphomevalonate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814:SF2">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017288">
        <property type="entry name" value="PMK_GHMP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13 15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="16">
        <location>
            <begin position="178"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="17">
        <location>
            <begin position="356"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR017288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ88370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="460" mass="49157" checksum="3B2A057C8B4E06C7" modified="2006-03-21" version="1">MAGGSDNPGNRTVVVSAPGKVLLAGGYIVLDRKHTGLVFGLSARIHVLAQEIHTSAGVHLREIVVQSPQFLNATWKYGYHLAENGGGIKVTQLQSGTPVDQNHFVETTLSYVLSYISQVDKTRATHGFQPASLLVLADNDYYSKPKEEPTTTTAAAAAAADGKKSRFLHFGTTLRDAHKTGLGSSAAIVTALTASLLAHYLPPHLFDLSTPAGRRALHNLAQVAHCAAQGKVGSGFDVASAVYGSSVYRRFSPALLAALPGPGEEGFARALVALVDGQGWDCEVRKEGVGLPAGVAIRMCDVDCGTQTVSMVKKVHAWRDAEPEVAAGVYAKLQGKVDELTAVLGEGRVGEIGRVMKPFRELMRTMGRECGAPIEPDSQEEMLDALEGVEGVLGSVVPGAGGYDAAAVVMWDDEETEKRVKAFLREWSKEHEIQVRLMGVKGETEGARMEDPSEFKLWTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZW2</accession>
    <name>Q2GZW2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224148.1">
        <property type="nucleotide sequence ID" value="XM_001224147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZW2"/>
    <dbReference type="GeneID" id="4391763"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04934"/>
    <dbReference type="HOGENOM" id="CLU_2512424_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZW2"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="85" mass="8808" checksum="462DF4FB144C7FDE" modified="2006-03-21" version="1">MGFSSTTTTTKSPTKCPANAPSSFSPSSSSSRHRDAPAGDMYTQLPSSLPSTRKNNPRAVTVEDEDEVEIEIEIDFGGATAGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZZ2</accession>
    <name>Q2GZZ2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Bms1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_04904</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224118.1">
        <property type="nucleotide sequence ID" value="XM_001224117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZZ2"/>
    <dbReference type="FunCoup" id="Q2GZZ2">
        <property type="interactions" value="1237"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GZZ2"/>
    <dbReference type="GeneID" id="4392049"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04904"/>
    <dbReference type="eggNOG" id="KOG1951">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002486_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZZ2"/>
    <dbReference type="OMA" id="KLHVPMV"/>
    <dbReference type="OrthoDB" id="10260897at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000232">
        <property type="term" value="P:regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01882">
        <property type="entry name" value="BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000105">
        <property type="entry name" value="BMS1 ribosome biogenesis factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037875">
        <property type="entry name" value="Bms1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="13">
        <location>
            <begin position="56"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="416"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="547"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="614"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="699"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1052"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="553"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="618"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="661"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="680"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="699"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ88285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1102" mass="125487" checksum="22E9E2A5FBF3858A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H006</accession>
    <name>Q2H006_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transglutaminase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001224103.1"/>
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    <dbReference type="STRING" id="306901.Q2H006"/>
    <dbReference type="GeneID" id="4393009"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04890"/>
    <dbReference type="eggNOG" id="KOG4575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016738_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H006"/>
    <dbReference type="OMA" id="HGKGFGH"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052557">
        <property type="entry name" value="CAP/Cytokinesis_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333:SF5">
        <property type="entry name" value="TRANSGLUTAMINASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="2">
        <location>
            <begin position="341"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="620" mass="66389" checksum="8DF3A777FD9D1682" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H009</accession>
    <name>Q2H009_CHAGB</name>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_04887</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
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        <property type="protein sequence ID" value="EAQ88268.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001224100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H009"/>
    <dbReference type="STRING" id="306901.Q2H009"/>
    <dbReference type="GeneID" id="4392594"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04887"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_455601_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H009"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003874">
        <property type="entry name" value="CDC45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507">
        <property type="entry name" value="CDC45-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507:SF0">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 45 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02724">
        <property type="entry name" value="CDC45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="112"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="378"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="537"/>
            <end position="599"/>
        </location>
    </feature>
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        <location>
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            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
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        <location>
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            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
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        </location>
    </feature>
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        <location>
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            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
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            <end position="472"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010727"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ88268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="599" mass="64721" checksum="995F0A421CCB42F3" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H065</accession>
    <name>Q2H065_CHAGB</name>
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        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_04831</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001224044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H065"/>
    <dbReference type="STRING" id="306901.Q2H065"/>
    <dbReference type="GeneID" id="4392578"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04831"/>
    <dbReference type="eggNOG" id="KOG2595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039465_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H065"/>
    <dbReference type="OMA" id="VYMFAQI"/>
    <dbReference type="OrthoDB" id="206700at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="GTPase-activating protein gyp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000060">
        <property type="entry name" value="TBC domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045913">
        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913:SF7">
        <property type="entry name" value="RE60063P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="53"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ88212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="424" mass="47392" checksum="97A6B0119F99B03B" modified="2006-03-21" version="1">MEESTKPLSLDEKAVNHKNATHASDEKKKAILEACSQRDLDALRALAQSPGGFLADSIRQRAWPVLLGLPSDNPKTGSSPNGTASVPAWESLPRHRDEDQVQLDVNRSFIYYPEHQTEAQLAHAKPLLSSLIVSVLRTHPYLCYFQGYHDIAQVLLLTLPPPLHQPSLTHLSLFHIRDFMLPSLAPAIAQLRLLPDILRLADPALWRHLSGTEPFFALSGTLTMYAHDVTTQGEIARLFDALLAAPDPAFSVYLFAAIVRARRAELFDTPPDEPEMLHSILSKLPVPLDLEGLIAQAVRLQAEFPPERLPAWRKGVSRWSVLKTGRRCGEGAGLVRVEQGRVWFERQVRELRWQETRERAGKWVWKHRRPAGMVGAAVLVGVLAVLLRRGPLPGPVVSGLGWVSEYVVRWCVVVCVEIVFLERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0S4</accession>
    <name>Q2H0S4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_04622</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04622"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000001056">
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="234"/>
        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ88003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="770" mass="84542" checksum="E9C3207FE9AABC79" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0V8</accession>
    <name>Q2H0V8_CHAGB</name>
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        <submittedName>
            <fullName evidence="5">Vacuolar ATP synthase subunit D</fullName>
        </submittedName>
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    <organism evidence="5 6">
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        <dbReference type="NCBI Taxonomy" id="306901"/>
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            <taxon>Pezizomycotina</taxon>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="194"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ87969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="244" mass="27237" checksum="F08EA871832023E6" modified="2006-03-21" version="1">MIDREAVFPTRQSLGIMKAKLKGAETGHSLLKRKNITRRIDEAKRKMGRVMQIASLSLAEVTYAVGGNIGYQIQESAKSARFRIRAKQENVSGVLLPAFESYLTEGNNDFAMTGLGKGGQQVQRCRETYARAVEALVELASLQTAFVILDEVIKVVNRRGSEHVIIPRTENTIKYINSELDELDREEFYRLKKKQRDTAAADAEMKKRKEESEEKGEENVAPGAEDSAGPTDLLVAAEDEDVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1L8</accession>
    <name>Q2H1L8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_04328</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223542.1">
        <property type="nucleotide sequence ID" value="XM_001223541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1L8"/>
    <dbReference type="GeneID" id="4391684"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04328"/>
    <dbReference type="eggNOG" id="ENOG502TF0E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1602493_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H1L8"/>
    <dbReference type="OrthoDB" id="5120070at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ87709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="166" mass="18647" checksum="B5660F34FF5FEBB7" modified="2006-03-21" version="1">MIRGFVYSGSSAIPPAPARRKLLPMMVCNLLKFYFTRAAQPEPGAILRLGCRDWISQVFIRLHATGLIAWEVSGIGGHEQPTRKIDERTSQHMLPTQSCIPIDWLAARGVGFHNIIGKAYDYDRAFDIVWYRPMNLRYGLYDGGFIRFAGSQGLTLAGVTHTLPYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1V5</accession>
    <name>Q2H1V5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="5 18">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CHGG_04241</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="17">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="5 18"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223455.1">
        <property type="nucleotide sequence ID" value="XM_001223454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1V5"/>
    <dbReference type="FunCoup" id="Q2H1V5">
        <property type="interactions" value="336"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H1V5"/>
    <dbReference type="GeneID" id="4391740"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04241"/>
    <dbReference type="eggNOG" id="KOG2958">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029960_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H1V5"/>
    <dbReference type="OMA" id="CFENRGA"/>
    <dbReference type="OrthoDB" id="418412at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000001">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000009">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12 18" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="11 17" id="KW-0408">Iron</keyword>
    <keyword evidence="9 16 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18 21" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="19">
        <location>
            <begin position="7"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase C-terminal" evidence="20">
        <location>
            <begin position="219"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="14">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="28"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="194"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="348"/>
            <end position="349"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="353"/>
            <end position="354"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EAQ87622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="385" mass="44208" checksum="5C71814F65C170A2" modified="2006-03-21" version="1">MPDQVLDDISHRRYNPLTGSWLLVSPHRTKRPWQGQQEAPSKNVLPEYDPKCYLCPGNQRAQGDSNPQYKNTFTFVNDYSAVKEQQQEYNPEANKDDVSSLLLRAQPVTGRCYVLTFSPKHDITLADMTAAEILPVIQTWTRIYASHLSTTSPLKVQADKILATIPANPDGEVDPPQNQLRYMQIFENKGAAMGCSNPHPHCQIWTTSTLPEEPSKELAEMSKYRAENGRHLLADYTKLEIEKQERVVWQNGGFLVVCPWWAVWPFEVIIIAKRHVRALVDLTDEERLQFAEAVQEVTRRYDNLFETNFPYSSGIHQAPLDCTEEEAENSWFHMHFYPPLLRSATVRKFLVGYELMAEPQRDITPEQAAARLRGCDGELYRKSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2D8</accession>
    <name>Q2H2D8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit beta'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_04058</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasmic vesicle</location>
            <location evidence="1 13">COPI-coated vesicle membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="13">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223272.1">
        <property type="nucleotide sequence ID" value="XM_001223271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2D8"/>
    <dbReference type="FunCoup" id="Q2H2D8">
        <property type="interactions" value="1159"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H2D8"/>
    <dbReference type="GeneID" id="4392919"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04058"/>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2Q5</accession>
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            <fullName evidence="6">STAS domain-containing protein</fullName>
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            <taxon>Chaetomium</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50801"/>
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        <source>
            <dbReference type="EMBL" id="EAQ87322.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
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    </evidence>
    <sequence length="798" mass="87145" checksum="F73AF1B6CDB399D7" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2Y8</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CHGG_03858</name>
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        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
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        <dbReference type="NCBI Taxonomy" id="306901"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223072.1">
        <property type="nucleotide sequence ID" value="XM_001223071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2Y8"/>
    <dbReference type="GeneID" id="4392085"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03858"/>
    <dbReference type="HOGENOM" id="CLU_1570443_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2Y8"/>
    <dbReference type="OrthoDB" id="10565479at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="170" mass="18536" checksum="7ABC4F410BD39FED" modified="2006-03-21" version="1">MANPDGDGTQLPSPEPTRHETALVLSTQARSDVAMTKLAFITADLARKREELEQFAISAKVLQEALEKNAAERQQLMAEVYGLTNNDYNDINDTDPKVASLEEKVAMLEAEVAELEAKEREMTMICAHASKGAASAGDKNDNDDSWMAMKVTAHGMTTHGMMTKVQTHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H367</accession>
    <name>Q2H367_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4-coumarate:coenzyme A ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_03779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222993.1">
        <property type="nucleotide sequence ID" value="XM_001222992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H367"/>
    <dbReference type="STRING" id="306901.Q2H367"/>
    <dbReference type="GeneID" id="4391621"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03779"/>
    <dbReference type="eggNOG" id="ENOG502QZFD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2209729_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H367"/>
    <dbReference type="OMA" id="KRSEVWI"/>
    <dbReference type="OrthoDB" id="5194807at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ87160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="12329" checksum="C9918E6E570CDFBE" modified="2006-03-21" version="1">MPVRIPATTRTEVFCMGAAGVTGFAPFYLMAPGAEERLSRQTVKWAPRWERNITFFRNPVERGIQRISPPVERTVKRIEHRLPLEKAAKKTDMSIKRNLDRLGIKHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3D6</accession>
    <name>Q2H3D6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_03710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222924.1">
        <property type="nucleotide sequence ID" value="XM_001222923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3D6"/>
    <dbReference type="GeneID" id="4392775"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03710"/>
    <dbReference type="eggNOG" id="ENOG502TD94">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_459264_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3D6"/>
    <dbReference type="OMA" id="NEQEERW"/>
    <dbReference type="OrthoDB" id="4579962at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF7">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ87091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="594" mass="67055" checksum="1AF5B7C151370C34" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3Q1</accession>
    <name>Q2H3Q1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_06714</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222809.1">
        <property type="nucleotide sequence ID" value="XM_001222808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3Q1"/>
    <dbReference type="STRING" id="306901.Q2H3Q1"/>
    <dbReference type="GeneID" id="4391406"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06714"/>
    <dbReference type="eggNOG" id="ENOG502RY37">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065859_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3Q1"/>
    <dbReference type="OMA" id="TNEGRFT"/>
    <dbReference type="OrthoDB" id="2141316at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF1">
        <property type="entry name" value="RHAMNOGALACTURONAN ACETYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208916" evidence="4">
        <location>
            <begin position="20"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ90095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="263" mass="27742" checksum="D742B794CFADB753" modified="2006-03-21" version="1">MLSWSTFLATGLAASGAYSAPVEVARRATPTVYLAGDSTMAKTSGALMGWGEYLSKYITLPVVNKAISGRSARSYTNEGRFSEIEKLVQRDDIVVIEFGHNDGGSPNSASDNGRSDCPGTGNEVCKSGKTGETVYTFNHYVETAARSYIAKGAKVIVSSQTPNNLFEGGTFIPGAPRFVGYAALAAKNVGNGASFLDHFQAVANMFLKLGSAKTNALFPQDHTHTSPAGADLVAQAFVQAIGRDFNGTTPLKGFLKSPVPVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3Q4</accession>
    <name>Q2H3Q4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_06711</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222806.1">
        <property type="nucleotide sequence ID" value="XM_001222805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3Q4"/>
    <dbReference type="GeneID" id="4391403"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06711"/>
    <dbReference type="eggNOG" id="ENOG502RYZ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009377_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H3Q4"/>
    <dbReference type="OMA" id="CKPSLCW"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="327"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="105"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="654"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="664"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ90092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="720" mass="79002" checksum="42D115520501F5B3" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4C1</accession>
    <name>Q2H4C1_CHAGB</name>
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        <recommendedName>
            <fullName evidence="5">Pre-rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_06494</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the RIX1 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the IPI1/TEX10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4C1"/>
    <dbReference type="STRING" id="306901.Q2H4C1"/>
    <dbReference type="GeneID" id="4390645"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06494"/>
    <dbReference type="eggNOG" id="KOG2149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126652_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4C1"/>
    <dbReference type="OMA" id="YLECLGM"/>
    <dbReference type="OrthoDB" id="361362at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein Ipi1 N-terminal" evidence="6">
        <location>
            <begin position="131"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ89875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="183" mass="19991" checksum="5766B90255337D31" modified="2006-03-21" version="1">MGSSNKKKKEKKKDFQKAKLKVGKAKAKAANFTDTSFKSKSIVVNQQTLSTDGSDPIEQFKLNLSLAINAKSDNQRRDALAHITNQLSANPPNNPVGASGVLTKLLPILSDGSMSVRTQLLKLLRALPPAEVGPHVEKVLMYIRGGMTHLSIDIRTRYLECLGMAPRDCWGPNWSPGPWGLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4F7</accession>
    <name>Q2H4F7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222553.1">
        <property type="nucleotide sequence ID" value="XM_001222552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4F7"/>
    <dbReference type="GeneID" id="4390254"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06458"/>
    <dbReference type="eggNOG" id="ENOG502QR14">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041456_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4F7"/>
    <dbReference type="OMA" id="CESAWTL"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="25825" checksum="4DF1B414A5EBE084" modified="2006-03-21" version="1">MAKDKRSRAAAPPPTTAPDITATTPSWPPFKPSLPVVDLTLDPLVKDKVVVLRSFFPRSLCKDYVSFLKELPLITTPGKPKRGDAVRVNDRYQIDDAKFAHRLWTETGLKEALAGKDVAQLCPLPARTTWTLLLYLTSSADGCIGGETVFYPHDRRSAKEEIAVSLETGMLLLHKHGHDCMLVSALLPFSGLPTHYIILLYSASHGTGEPTKQIWSAPAFLDLDLSSCVGDSQTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4T8</accession>
    <name>Q2H4T8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_06327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222422.1">
        <property type="nucleotide sequence ID" value="XM_001222421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4T8"/>
    <dbReference type="GeneID" id="4389939"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06327"/>
    <dbReference type="eggNOG" id="ENOG502SVX1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_517774_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4T8"/>
    <dbReference type="OrthoDB" id="5421765at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36911">
        <property type="entry name" value="LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="526" mass="56963" checksum="6C5BA2B98C60D6C6" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4X7</accession>
    <name>Q2H4X7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein eL24-related N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_06288</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222383.1">
        <property type="nucleotide sequence ID" value="XM_001222382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4X7"/>
    <dbReference type="FunCoup" id="Q2H4X7">
        <property type="interactions" value="770"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H4X7"/>
    <dbReference type="GeneID" id="4390647"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06288"/>
    <dbReference type="eggNOG" id="KOG1722">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106411_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4X7"/>
    <dbReference type="OMA" id="PGHGKKM"/>
    <dbReference type="OrthoDB" id="1727108at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL24-related N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="109"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ89669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="161" mass="18085" checksum="2DD5EC52AA85078D" modified="2006-03-21" version="1">MRTYDDSFSGQRIYPGKGKLYVRGDSKIFRFQNGKSESLFLQRKNPRRIAWTVLYRRQHRKGISEEVAKKRTRRTVKSQRAIVGASLDVIKERRSIRPETRSAARLAAIKESKEKRQAEQAAKKAEKAKNAAAASKGQSGGRIVGKQGAKGAQQKVAANTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H520</accession>
    <name>Q2H520_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_06245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222340.1">
        <property type="nucleotide sequence ID" value="XM_001222339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H520"/>
    <dbReference type="GeneID" id="4391160"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06245"/>
    <dbReference type="HOGENOM" id="CLU_2440643_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H520"/>
    <dbReference type="OrthoDB" id="2823490at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="90" mass="10045" checksum="6C95BA0E098384C8" modified="2006-03-21" version="1">MAEPTYHKATLLGLPTELRLQILEEAIAVRHAAPKSPSDIRNRRTRHYPHGSFLPARGNINVYARRRNISSGGFLATRTGLTSCYWASLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H541</accession>
    <name>Q2H541_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Arg-6 protein, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CHGG_06224</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 17">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">In the C-terminal section; belongs to the NAGSA dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">In the N-terminal section; belongs to the acetylglutamate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222319.1">
        <property type="nucleotide sequence ID" value="XM_001222318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H541"/>
    <dbReference type="FunCoup" id="Q2H541">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H541"/>
    <dbReference type="GeneID" id="4390401"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06224"/>
    <dbReference type="eggNOG" id="KOG2436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006384_4_0_1"/>
    <dbReference type="InParanoid" id="Q2H541"/>
    <dbReference type="OMA" id="IAFIPHV"/>
    <dbReference type="OrthoDB" id="438291at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04252">
        <property type="entry name" value="AAK_NAGK-fArgBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23936">
        <property type="entry name" value="AGPR_C_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24149">
        <property type="entry name" value="AGPR_N_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000019">
        <property type="entry name" value="Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000011">
        <property type="entry name" value="N-acetyl-gamma-glutamyl-phosphate reductase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058924">
        <property type="entry name" value="AGPR_dimerisation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041734">
        <property type="entry name" value="NAGK-fArgBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011241">
        <property type="entry name" value="NAGK/NAGSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF0">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22698">
        <property type="entry name" value="Semialdhyde_dhC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036440">
        <property type="entry name" value="ARG5-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 17" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="11 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="15 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16 17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12 17" id="KW-0521">NADP</keyword>
    <keyword evidence="9 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="19">
        <location>
            <begin position="337"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="active site" evidence="18">
        <location>
            <position position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR036440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EAQ89605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="828" mass="90978" checksum="E34BC2D4E0D75692" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H786</accession>
    <name>Q2H786_CHAGB</name>
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        <recommendedName>
            <fullName evidence="2">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001221573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H786"/>
    <dbReference type="STRING" id="306901.Q2H786"/>
    <dbReference type="GeneID" id="4391019"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05479"/>
    <dbReference type="eggNOG" id="ENOG502S9NK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013057_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H786"/>
    <dbReference type="OMA" id="NHVRFDP"/>
    <dbReference type="OrthoDB" id="5226662at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42081:SF2">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42081">
        <property type="entry name" value="ZINC FINGER PROTEIN DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="474"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="829" mass="92281" checksum="5F17E93673A414C6" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7A5</accession>
    <name>Q2H7A5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88841.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7A5"/>
    <dbReference type="GeneID" id="4391028"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05460"/>
    <dbReference type="eggNOG" id="ENOG502SQD8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1731249_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7A5"/>
    <dbReference type="OrthoDB" id="10004862at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="151" mass="16839" checksum="187AB6C3E5312C53" modified="2006-03-21" version="1">MDSHGGLDPPEMEFDSWGDSRTSNDRPPGVVECTRNMMELRFPEEIGGEVEERWLGLEEGWVYRSSWGEEKMMKFVEGLDEMEVVVKEVTEAEARGADPKFVLSICGPSAINSVRKTMPKLDENLRTSAAALPLPRGSISSKGLTHLPRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7G8</accession>
    <name>Q2H7G8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_05397</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001221491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7G8"/>
    <dbReference type="FunCoup" id="Q2H7G8">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="GeneID" id="4389982"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05397"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="InParanoid" id="Q2H7G8"/>
    <dbReference type="OMA" id="AMLICQV"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF153">
        <property type="entry name" value="AFLATOXIN EFFLUX PUMP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="56"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ88778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="567" mass="59788" checksum="8EA96C11B85F427E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7U5</accession>
    <name>Q2H7U5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221365.1">
        <property type="nucleotide sequence ID" value="XM_001221364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7U5"/>
    <dbReference type="GeneID" id="4391295"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05270"/>
    <dbReference type="eggNOG" id="ENOG502QQPD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_538823_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7U5"/>
    <dbReference type="OMA" id="CAFNHEP"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="56265" checksum="6BCBD8084F0DB39A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8D6</accession>
    <name>Q2H8D6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL14m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_03518</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230034.1">
        <property type="nucleotide sequence ID" value="XM_001230033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8D6"/>
    <dbReference type="FunCoup" id="Q2H8D6">
        <property type="interactions" value="317"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H8D6"/>
    <dbReference type="GeneID" id="4388556"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03518"/>
    <dbReference type="eggNOG" id="KOG0901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095071_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H8D6"/>
    <dbReference type="OMA" id="IVCVVQK"/>
    <dbReference type="OrthoDB" id="274765at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000005">
        <property type="entry name" value="50S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_uL14_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ91583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="128" mass="13960" checksum="2301BA6DC3D1B4A1" modified="2006-03-21" version="1">MVRSMLNCIDNSGAAIVECAMVIGQKRHASIGDRIVVVVQKQRGAQAEGMAASSGTKVKRGDIRHAIVVRTKYKVQRRDGSVIRFDDNACVLINKSGDPIGSRINGVVGQELRKKKWSRILSMAPMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8H9</accession>
    <name>Q2H8H9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229991.1">
        <property type="nucleotide sequence ID" value="XM_001229990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8H9"/>
    <dbReference type="STRING" id="306901.Q2H8H9"/>
    <dbReference type="GeneID" id="4389182"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03475"/>
    <dbReference type="eggNOG" id="KOG0922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_596628_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8H9"/>
    <dbReference type="OMA" id="KNTHAYH"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="203"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="390" mass="42399" checksum="F538ECF9C74D3CCD" modified="2006-03-21" version="1">MDDLSDLELAGLVVSEVEIHLGVVDKNLADLIIAQRVASDTFEIFQQKMGSMAGVSLPVSLLKSVDRLLRMMHPSIKAKNTHAYHGPGTQRGVEQPHVRSQAYIEAQAQSRPSLPGQAANQAPVQDLINNPRKRGRSRSRSNSPNTQGNRRLRSNPSDYDRPRRTPYDADLDRLIMEDGERRGRQGRCEDDHSQREDEVPVLNNIYDGHVAGVKKFGAFVNLQIGIGNVTGLVHASKLAEGLNHPSNLVARGPSSERPVPPQNTSGRRHHPRGGETQQLTAAGVLKASDFPGLEDHNAALGVDGGMGLGEDLGIELKSEEPPFLIGQPTQSLERLSIRLIKTPDGTMSRAAVSGSVLAKERPELQLQRAARKSTTPSPPAPCTTPRQTHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8J2</accession>
    <name>Q2H8J2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_03462</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229978.1">
        <property type="nucleotide sequence ID" value="XM_001229977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8J2"/>
    <dbReference type="GeneID" id="4389428"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03462"/>
    <dbReference type="eggNOG" id="ENOG502SNZ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1026719_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8J2"/>
    <dbReference type="OMA" id="TTKISIC"/>
    <dbReference type="OrthoDB" id="3648173at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="42"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ91527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="271" mass="30355" checksum="A203D16DAAA117D5" modified="2006-03-21" version="1">MGARAPFVDGDSRDAGAADEGTPSSFRFDANFMPTALNPVQALYASIINYNIANNVVKMSFTLQYRRIFGSSSPTADQVCRWFFFFLMVWAVVQAILLGLSCVPLAVIVPSMAGKCLDTVPVWYASQSLNVFTDFLIFSVPLPYVYKLTMPTKEKFLVLGIFSLGFFTWTISVIRLSYLGAVPVARDPTWDNVELTLWSVTELNCGILCACLQTLRPLLSKFKICSSHLGYDNRRCVRRPLSDGVFLETAPLTRRISHESDNEDRHDQEFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8L8</accession>
    <name>Q2H8L8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Palmitoyltransferase</fullName>
            <ecNumber evidence="13">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_03436</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Palmitoyltransferase specific for casein kinase 1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="13"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229952.1">
        <property type="nucleotide sequence ID" value="XM_001229951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8L8"/>
    <dbReference type="FunCoup" id="Q2H8L8">
        <property type="interactions" value="536"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H8L8"/>
    <dbReference type="GeneID" id="4389661"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03436"/>
    <dbReference type="eggNOG" id="KOG0509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012510_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H8L8"/>
    <dbReference type="OMA" id="FWVGFRY"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="468"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="15">
        <location>
            <begin position="419"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="576"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="576"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAQ91501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="713" mass="78129" checksum="04DEF6E672283116" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8V3</accession>
    <name>Q2H8V3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF788 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_03351</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM208 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229867.1">
        <property type="nucleotide sequence ID" value="XM_001229866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8V3"/>
    <dbReference type="FunCoup" id="Q2H8V3">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H8V3"/>
    <dbReference type="GeneID" id="4388955"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03351"/>
    <dbReference type="eggNOG" id="ENOG502S72U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094308_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H8V3"/>
    <dbReference type="OMA" id="GRPKYDA"/>
    <dbReference type="OrthoDB" id="10012212at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008506">
        <property type="entry name" value="SND2/TMEM208"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05620">
        <property type="entry name" value="TMEM208_SND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ91416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="17620" checksum="49F70F41945943B0" modified="2006-03-21" version="1">MAQKARKDRAKSNTAALNNLHIGSVIVNGLFLLLHFVFRSRSLLLWFLLSLPSFLCQITLERTGRPSYDPDTKALKSSGEDLAAPGLTDYMFDVVWVTWAAAILVAFFGNWAWFFWLVVPAYGGYKAFGMMGAAKQMAQMGGNANAGAPAAAGNRKQRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8V9</accession>
    <name>Q2H8V9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229861.1">
        <property type="nucleotide sequence ID" value="XM_001229860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8V9"/>
    <dbReference type="GeneID" id="4389270"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03345"/>
    <dbReference type="eggNOG" id="ENOG502RK14">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_552287_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8V9"/>
    <dbReference type="OMA" id="PEHTEHY"/>
    <dbReference type="OrthoDB" id="4590106at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="507" mass="55394" checksum="B3CF8A0A94CE4BC3" modified="2006-03-21" version="1">MSQAVSGWDCLGDAAQFGIILVIVAVVLALVYLYWRLQIKPGLQSGRDDSQNPVTGHWELSRRDPSRVSITIYREPRQLSDPEPVETDGPISPPGKGQIGQTQQQENNILGQVPQQLGMAHTSDIHLVPPPPPPPPVVWSASPSSTVPQPPIVGPIAFVQSGHPPATFHSTPLTLGTTTVPYPADVPPPYFGYANLQGQYPQAEVVPVPQPACAPPPVTPSTPTRNKKEKNVPTTPVAEPQSKWRRWFSRGKSPATGHARTLSDSSSPGQPVQVTVTSTISDPITSAQAARDRRHNTPPSESESSISSSYLNTSLEAVLNTNNPHPTRSTRTRTRPRPRPRAFSNPETTQPHHQHPNRAPQTRIRPSDTVPLAHDLHRRQLSDDSRQPGPSQRQRQRQRRHPTPSPDLQFPSPERRRPRVSFTLPEEEEQEGRGGVLGASSSAGSSSVSLGSLESGRSVELRGEGRSRERETRGGGGGGRRREEEEEEAEEEGRRPGVADRVTRGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8W6</accession>
    <name>Q2H8W6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protein PBN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_03338</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGX family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229854.1">
        <property type="nucleotide sequence ID" value="XM_001229853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8W6"/>
    <dbReference type="STRING" id="306901.Q2H8W6"/>
    <dbReference type="GeneID" id="4389493"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03338"/>
    <dbReference type="eggNOG" id="ENOG502QS8N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030047_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8W6"/>
    <dbReference type="OMA" id="HELHIRW"/>
    <dbReference type="OrthoDB" id="5546453at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042322">
        <property type="entry name" value="Pbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533:SF1">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00780">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="437"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ91403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="488" mass="52217" checksum="C4ABD957CC5D354A" modified="2006-03-21" version="1">MRERISFVQKLGDSLEPSALTVNDGVIKGPEVHAVREDRLTIAANELPSELRTLVTGAQDLHIRWVSTAAYETVSPLLARLPPGFHLFFTPGRNHAVTKGLCSILGNIFGDISCTTPDESFTVVGEERFQYFQELDSLSHFIQYAKGQLCGATDASCSARLDTLSTAGTLDMSYDIGERVLRVTALWPYQRQQVHATSRPNTRTEVGILSTDKPKTLEAHEIGISGLLTVLGQDSKPSPTMFSFGSRHRDAESAFSARFLAPTGLHPTLQLRLTADGPPPSSSDDEDATTTCTPYAYLTLPRTIFADKYQLSDPLFLASKNLTALRHTTQPVDLEAPAYVMTQWGSSVLLELSPPPAQERRKGGGGEWTASIPLHLRYLAPAPGGYSTIAVPYPGRVLGVRARAGGRVPAEPVREAPPGVRRAVWGGHGVLARRAEAGGSGGVAGERGQGAGAGRGQGRVGERGDGGSCVGWVRVGCVEDRWGLGQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9A9</accession>
    <name>Q2H9A9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229711.1">
        <property type="nucleotide sequence ID" value="XM_001229710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9A9"/>
    <dbReference type="GeneID" id="4389910"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03195"/>
    <dbReference type="HOGENOM" id="CLU_918277_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9A9"/>
    <dbReference type="OrthoDB" id="4922674at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718">
        <property type="entry name" value="OS01G0519700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718:SF10">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="303" mass="34717" checksum="45F3EA865E09955B" modified="2006-03-21" version="1">MPFLNVTGVTNTHSTFNIAFGVINKEDKPAYTWALERLENLRTEIGADYPYVVVTDFEMALKSASDNVWGDVQQQICLWHVNKNVFFEVKKRWVWAADQQPPEEVEEVDETDDHVDPIFRDLVAAAGREDQSVTLGSLPTKVEDNPTGFLKLWKHLCYAATPDDFVAAWVKILEDFSQQEAIISYLQTTLRATEITRVRVRGSTSPTADICHTQIKSSNFNQAPRNQHRGPTIIVTYDQLGSIFRRARHMYKPTEFSMEAEDEEEDPVEEVDQRLAEAQDDARGQAERRIAKMERRLENIPIT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9G6</accession>
    <name>CBPYA_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Carboxypeptidase Y homolog A</fullName>
            <ecNumber>3.4.16.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CPYA</name>
        <name type="ORF">CHGG_03138</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Release of a C-terminal amino acid with broad specificity.</text>
            <dbReference type="EC" id="3.4.16.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.5"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229654.1">
        <property type="nucleotide sequence ID" value="XM_001229653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9G6"/>
    <dbReference type="SMR" id="Q2H9G6"/>
    <dbReference type="FunCoup" id="Q2H9G6">
        <property type="interactions" value="749"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H9G6"/>
    <dbReference type="ESTHER" id="chagb-q2h9g6">
        <property type="family name" value="Carboxypeptidase_S10"/>
    </dbReference>
    <dbReference type="MEROPS" id="S10.001"/>
    <dbReference type="GlyCosmos" id="Q2H9G6">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="GeneID" id="4389770"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03138"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008523_10_4_1"/>
    <dbReference type="InParanoid" id="Q2H9G6"/>
    <dbReference type="OMA" id="GDWMKPF"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.410:FF:000001">
        <property type="entry name" value="Carboxypeptidase Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008442">
        <property type="entry name" value="Propeptide_carboxypepY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05388">
        <property type="entry name" value="Carbpep_Y_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0121">Carboxypeptidase</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000407443" evidence="1">
        <location>
            <begin position="18"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000407444" description="Carboxypeptidase Y homolog A">
        <location>
            <begin position="138"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="529"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="518"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="191"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="394"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="554" mass="61851" checksum="7D613BD299241E48" modified="2006-03-21" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9P3</accession>
    <name>Q2H9P3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229577.1">
        <property type="nucleotide sequence ID" value="XM_001229576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9P3"/>
    <dbReference type="GeneID" id="4389085"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03061"/>
    <dbReference type="eggNOG" id="ENOG502T2VA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067163_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9P3"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="22907" checksum="21B0188E7948ED7F" modified="2006-03-21" version="1">MEHTPDTTGSLSAQSHHDRTRACPVTPRQDPGGDSHSCIIDYRREAFKVTWWGRVECPGLTKFPAVGDAEVSPVPLTPALAAAWKQSSPLNHGCYASVRASDGPGDRFPVLKVAHPDSPSVDLIEGEFNVLNSLRGRGTSGARGGPAPHRGQWAHPRVPDAPALQVGARIVLVDFGFAGRIGTVVPPSIPSWVYTGPVFAAEEDLTALDDLCLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9Y9</accession>
    <name>Q2H9Y9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229481.1">
        <property type="nucleotide sequence ID" value="XM_001229480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9Y9"/>
    <dbReference type="GeneID" id="4389717"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02965"/>
    <dbReference type="eggNOG" id="ENOG502QQ65">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_458538_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9Y9"/>
    <dbReference type="OMA" id="QPNDATW"/>
    <dbReference type="OrthoDB" id="4590563at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="595" mass="64816" checksum="0C2089FC773B9177" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9Z8</accession>
    <name>Q2H9Z8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidoligase enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_02956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229472.1">
        <property type="nucleotide sequence ID" value="XM_001229471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H9Z8"/>
    <dbReference type="STRING" id="306901.Q2H9Z8"/>
    <dbReference type="GeneID" id="4389779"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02956"/>
    <dbReference type="eggNOG" id="ENOG502SSWJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071104_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H9Z8"/>
    <dbReference type="OMA" id="ANNRYCK"/>
    <dbReference type="OrthoDB" id="5291055at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ91021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="30698" checksum="4D10679D8AD041A4" modified="2006-03-21" version="1">MAHPLLVAAPCYTFAVDIEARAEPHKVRPPLHEKHALYHGKLAAALRNRGLEANAADDSNSRRPDGDNGWWITRNGSLGVPLDTSMISIEAVSPALDTRADWGAEIDTFWSALRAVFHMPERSDLCGSHVHVARSRVERFTLPQLKTIAYAAVVYESFVTELLLPARRESIFCKPNTQSSDYLYRVKGDPGAVARLIDSAGGEEELRNIMQSRYFSARLTLHKNELYDPSPDGRRRLPSTDILYAEVRMAAAEMDMQHHLPVNHERFNETLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HA72</accession>
    <name>Q2HA72_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_02882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229398.1">
        <property type="nucleotide sequence ID" value="XM_001229397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HA72"/>
    <dbReference type="STRING" id="306901.Q2HA72"/>
    <dbReference type="GeneID" id="4389185"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02882"/>
    <dbReference type="eggNOG" id="KOG4044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066901_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HA72"/>
    <dbReference type="OMA" id="HVCVFQT"/>
    <dbReference type="OrthoDB" id="269496at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050993">
        <property type="entry name" value="Isochorismatase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119:SF3">
        <property type="entry name" value="ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="14"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ90947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="215" mass="22995" checksum="72536A8D0564350C" modified="2006-03-21" version="1">MAAPVPERRFKNPAVFVCDIQEKFRPSIYEFDKVVLTTRKLLRAATTLQIPIFVTTQNRARLGDTVAELQPDLTAAGPLVLANTDKTRFSMWLPPISTYFSSLPPPNNSPPTPSEIALVGIESHICITQTALDLLAAGHRVYVLADGVSSSNREEVGIALARVAAAGAVVTTSEGWIYECMGDAGIPEFKGMIGVVKEAVGDTRAALTGLVGSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAA7</accession>
    <name>Q2HAA7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_02847</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229363.1">
        <property type="nucleotide sequence ID" value="XM_001229362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAA7"/>
    <dbReference type="FunCoup" id="Q2HAA7">
        <property type="interactions" value="927"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HAA7"/>
    <dbReference type="GeneID" id="4389584"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02847"/>
    <dbReference type="eggNOG" id="KOG3298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085878_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HAA7"/>
    <dbReference type="OMA" id="TMRQPGL"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990328">
        <property type="term" value="C:RPB4-RPB7 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010590">
        <property type="term" value="P:regulation of septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="9">
        <location>
            <begin position="8"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="78"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ90912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="202" mass="22505" checksum="0B0AC5FB06F614ED" modified="2006-03-21" version="1">MFFLHNLERRVTLHPSYFGRNMHELVTTKLVKDVEGTCAGDYYIIAIMDTFDVSEGRILPGSGLAEFTVGYRAVVWRPFKGEVIDAITQTVNPHGFFAQAGPLRLFVSSHLMPDEIQYDASATPAQFTNNADIVIEQGTHVRVKIIGLRTEVGEMWAIGSINGDFLGYVLVLDYTLRIIAMLTVLILQLPPGIISRKQTMAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HAV9</accession>
    <name>Q2HAV9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_02645</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EMC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229161.1">
        <property type="nucleotide sequence ID" value="XM_001229160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HAV9"/>
    <dbReference type="FunCoup" id="Q2HAV9">
        <property type="interactions" value="155"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HAV9"/>
    <dbReference type="GeneID" id="4389488"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02645"/>
    <dbReference type="eggNOG" id="KOG3060">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052388_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HAV9"/>
    <dbReference type="OMA" id="LMEMLFY"/>
    <dbReference type="OrthoDB" id="124397at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055217">
        <property type="entry name" value="TPR_EMC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22890">
        <property type="entry name" value="TPR_EMC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="EMC2 TPR-like" evidence="5">
        <location>
            <begin position="107"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ90710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="345" mass="37746" checksum="BB1303A362E7BC25" modified="2006-03-21" version="1">MAPPILNSPIQLSPAAALALSQQTPAFLRSSPSTVSSSPLSTLFSGPEKSEQWLQYENLIVSCLRTGDDQAAHQCLQRLVARFGDDNERVQAIRGLVKEAEAQGNGALEEVLNEYNQILNENDANIPIAKRRVALLRSMGRLPDAASALVQLLDFSPTDAEAWSELSDIYLSQGLYPQAIYAMEEVLVLAPNAWNVCSPTKAPNLSPMLMHPSQIHARLGELQYMAATAPGLANGLYQKYMAEAVKRFSRSIELCDDYLRGYYGLKLVSKRLLNDGTKAIRPADDSEFALPDTNTIEQLNELATAKLSEIVRHSAASDRGWRGYSEAEVAAARDLLADDASAIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HB55</accession>
    <name>Q2HB55_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">magnesium chelatase</fullName>
            <ecNumber evidence="1">6.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_02549</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism.</text>
    </comment>
    <dbReference type="EC" id="6.6.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229065.1">
        <property type="nucleotide sequence ID" value="XM_001229064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HB55"/>
    <dbReference type="GeneID" id="4389395"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02549"/>
    <dbReference type="eggNOG" id="ENOG502QQMN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034390_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HB55"/>
    <dbReference type="OMA" id="HWHDPED"/>
    <dbReference type="OrthoDB" id="5582146at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016851">
        <property type="term" value="F:magnesium chelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.80">
        <property type="entry name" value="Magnesium chelatase subunit I, C-Terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052041">
        <property type="entry name" value="Nucleic_acid_metab_PIN/TRAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11603">
        <property type="entry name" value="AAA FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11603:SF132">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ChlI/MoxR AAA lid" evidence="4">
        <location>
            <begin position="357"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="224"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="277"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ90614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="458" mass="49776" checksum="F2A13873E424AA7E" modified="2006-03-21" version="1">MADEQLLDKIHNLSDLELAALLGLIAREHCLISTEPDSVNELAEELRLIASKTFNLSSAIISCHAHTTLDEFATGLCVPPNRAPPSPGNTRSVSPYRPRHEQSQLSVGGPGPSSGSYFPLTSSPRIGGAVSPISPGSSSQTPQPRIANVILAKDLDRAPRAIQIQALELLRTRRIFTRTSVQTAPKQFLFIAVVGANGVGQARVTPHLNDFFYLSHWHDPEEDGFPYLDEEYSPQPRPSNDDNQDDAASTRSSTSVVKLNRHASLAITGLGIPAVDHQDHWRHRKDSTASSVRSGGIPSLSPQHRHQHQHPPTQPRTQPPQHTLTETEISHLSQLSRTTHTSIALTRYQFNLISFLRTHRAVAPGCVSPTATQHLARLSASLAPLHGLDYVTPALVALAVRKVYAHRVRVVGGEEGVGVERERSVQWGSEVGVVRGLLEGVGVEEVLEEVLGAVRVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBA3</accession>
    <name>Q2HBA3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_02501</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229017.1">
        <property type="nucleotide sequence ID" value="XM_001229016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBA3"/>
    <dbReference type="FunCoup" id="Q2HBA3">
        <property type="interactions" value="860"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HBA3"/>
    <dbReference type="MEROPS" id="C19.972"/>
    <dbReference type="GeneID" id="4389709"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02501"/>
    <dbReference type="eggNOG" id="KOG2026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016848_2_1_1"/>
    <dbReference type="InParanoid" id="Q2HBA3"/>
    <dbReference type="OMA" id="QLRRFKC"/>
    <dbReference type="OrthoDB" id="10263353at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02669">
        <property type="entry name" value="Peptidase_C19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000068">
        <property type="entry name" value="U4/U6.U5 tri-snRNP-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033809">
        <property type="entry name" value="USP39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF16">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="13">
        <location>
            <begin position="80"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="202"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ90566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="552" mass="62721" checksum="728F4D3B2E952B20" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBL1</accession>
    <name>Q2HBL1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228909.1">
        <property type="nucleotide sequence ID" value="XM_001228908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBL1"/>
    <dbReference type="GeneID" id="4389281"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02393"/>
    <dbReference type="HOGENOM" id="CLU_1077696_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HBL1"/>
    <dbReference type="OrthoDB" id="4587639at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ90458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="258" mass="26557" checksum="16BAB5AAAB954977" modified="2006-03-21" version="1">MADAPRKKQPAPTSDTPATPSNTVKPGPTKPKVTKSTAAPTTSAKTVPGPSPPAKSTATSTPAKSTATSTSPGNTTKPTPTTASTSSTKLGSTSAASDSHGTAAPSATGGAKSASGPPAPVKRASSSSENGDADSQQQKKDTWMEAHWKKWSPQADKDRSYPVVFDKSPPAVKAKLIALLGGTEPKLTTMDTSLSYLEAASGKANPGPVQVAFVEADDFDKICEALDGDRIMIKVPVKDSKATKKRRAFVPTKEIKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBP6</accession>
    <name>Q2HBP6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription activator GCR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_02358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228874.1">
        <property type="nucleotide sequence ID" value="XM_001228873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBP6"/>
    <dbReference type="GeneID" id="4389090"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02358"/>
    <dbReference type="HOGENOM" id="CLU_009209_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HBP6"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060963">
        <property type="term" value="P:positive regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.20">
        <property type="entry name" value="Centromere DNA-binding protein complex CBF3 subunit, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052146">
        <property type="entry name" value="HOT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038279">
        <property type="entry name" value="Ndc10_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031872">
        <property type="entry name" value="NDC10_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022210">
        <property type="entry name" value="TF_GCR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37784:SF2">
        <property type="entry name" value="HIGH-OSMOLARITY-INDUCED TRANSCRIPTION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37784">
        <property type="entry name" value="PROTEIN MSN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12550">
        <property type="entry name" value="GCR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16787">
        <property type="entry name" value="NDC10_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ndc10" evidence="3">
        <location>
            <begin position="408"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription activator GCR1-like" evidence="2">
        <location>
            <begin position="912"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="826"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="856"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ90423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1011" mass="113334" checksum="F55EB4FD3BD7DB8E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBY8</accession>
    <name>Q2HBY8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_02266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228782.1">
        <property type="nucleotide sequence ID" value="XM_001228781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBY8"/>
    <dbReference type="GeneID" id="4388677"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02266"/>
    <dbReference type="HOGENOM" id="CLU_000288_34_1_1"/>
    <dbReference type="InParanoid" id="Q2HBY8"/>
    <dbReference type="OMA" id="HEYFRTW"/>
    <dbReference type="OrthoDB" id="5967843at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="251"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ90331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="834" mass="94658" checksum="51129E3230A62966" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HC69</accession>
    <name>Q2HC69_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD-dependent oxidoreductase 2 FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_02185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228701.1">
        <property type="nucleotide sequence ID" value="XM_001228700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HC69"/>
    <dbReference type="STRING" id="306901.Q2HC69"/>
    <dbReference type="GeneID" id="4388826"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02185"/>
    <dbReference type="eggNOG" id="KOG2404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022946_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HC69"/>
    <dbReference type="OMA" id="PEDHWPR"/>
    <dbReference type="OrthoDB" id="3345469at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014614">
        <property type="entry name" value="KsdD_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009472">
        <property type="entry name" value="PRK12834.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43260">
        <property type="entry name" value="3-KETOSTEROID-DELTA-1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43260:SF1">
        <property type="entry name" value="KSDD-LIKE STEROID DEHYDROGENASE RV0785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036654">
        <property type="entry name" value="UCP036654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="3">
        <location>
            <begin position="10"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ90250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="573" mass="62398" checksum="A6313B0A827DA7EE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCB4</accession>
    <name>Q2HCB4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Intradiol ring-cleavage dioxygenases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_02140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228656.1">
        <property type="nucleotide sequence ID" value="XM_001228655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCB4"/>
    <dbReference type="GeneID" id="4389643"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02140"/>
    <dbReference type="eggNOG" id="ENOG502QPRK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027719_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HCB4"/>
    <dbReference type="OMA" id="YVAGEYI"/>
    <dbReference type="OrthoDB" id="121380at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03457">
        <property type="entry name" value="intradiol_dioxygenase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF1">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209059" description="Intradiol ring-cleavage dioxygenases domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="3">
        <location>
            <begin position="136"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ90205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="379" mass="41293" checksum="C01EAA17C09B037D" modified="2006-03-21" version="1">MLAFALASLFIAGGLVSAHGPGHDHARERAERRQFLDIHTNSLGHCSNKHVAEGLYQRAIQRRELRARSLMAPSSLRALKARQTSSLGKPHKSDKDFDASTDPKEVFAGNNSCVLNPETTEGPFFVLGQDVRSELVDGQQGVPLHLDIQLIDVDTCEPIEGSFIEMWNANSTGVYSGALATVNGIGMSDLANLNRSFLRGSQKTDEDGVAQFQTIFPGHYEGRAPHIHVISHLNATARANNTLWDSRVTHVGQVFFDQDLVNSVKQVAPYSTNRQNLMQNAADNILLQEAATSDPFFHYVLLGEDLQKDGIFAWFSFGVNTTFTRDIMAAAMRFKDGGKMVTTNPKIPGLDRIFPGGFPTAYNPGFGGPPPSAPTGTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HCG8</accession>
    <name>Q2HCG8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_02086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221307.1">
        <property type="nucleotide sequence ID" value="XM_001221306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HCG8"/>
    <dbReference type="STRING" id="306901.Q2HCG8"/>
    <dbReference type="GeneID" id="4387088"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02086"/>
    <dbReference type="eggNOG" id="ENOG502RUYP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_780745_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HCG8"/>
    <dbReference type="OrthoDB" id="10531666at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46155">
        <property type="entry name" value="BIFUNCTIONAL INHIBITOR/LIPID-TRANSFER PROTEIN/SEED STORAGE 2S ALBUMIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46155:SF1">
        <property type="entry name" value="BIFUNCTIONAL INHIBITOR_LIPID-TRANSFER PROTEIN_SEED STORAGE 2S ALBUMIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="355" mass="37348" checksum="12E029260D187782" modified="2006-03-21" version="1">MATTGNHVTINGNGTTSFITKILAPVSSPVPVPVSTPVPVPVPAPVSTPVMTPASTPVSAAVPVPVSTPVPVPLSAPVPAPVLTPVMTPASTPVLTPVRAPVSTPVRAPVSTPALTPASTPMSTPVPGPVSTLASAMVSAFVSAVVSRPVPTPALTPTSTPVSNPVPTPVSTPVSVPASTLVSTPASTPPSSPHPTPRPIPSLDINANNTTTGTPDEPSEQTHYRVYLTTAFERDLLHHFIWVETKPNDISVNWGHAYRVDGNHHGMKHQFHICCDPFVDTSGRTKQHISWVRRQDNERVKEVCRSVAPPGPQPESNGLGRSDLRVPARNWKHWTADVIATLRTTGVLQPLTLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDT0</accession>
    <name>Q2HDT0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Cytidine deaminase</fullName>
            <ecNumber evidence="4 13">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 13">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_01624</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2'-deoxycytidine + H2O + H(+) = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>cytidine + H2O + H(+) = uridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="4 13"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220845.1">
        <property type="nucleotide sequence ID" value="XM_001220844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDT0"/>
    <dbReference type="FunCoup" id="Q2HDT0">
        <property type="interactions" value="134"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HDT0"/>
    <dbReference type="GeneID" id="4387094"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01624"/>
    <dbReference type="eggNOG" id="KOG0833">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097262_2_2_1"/>
    <dbReference type="InParanoid" id="Q2HDT0"/>
    <dbReference type="OMA" id="LTHFTCV"/>
    <dbReference type="OrthoDB" id="414540at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055086">
        <property type="term" value="P:nucleobase-containing small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072527">
        <property type="term" value="P:pyrimidine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000008">
        <property type="entry name" value="Cytidine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050202">
        <property type="entry name" value="Cyt/Deoxycyt_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
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        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004064">
        <property type="entry name" value="PRK05578.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644:SF2">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="25"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="66"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ93389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="172" mass="18278" checksum="E0B719D9E665F167" modified="2006-03-21" version="1">MPPPQPSTSPTAVTETCTTHNLTPTEFTTLLAHAQDAKTRAYCPYSRFRVGAALLTAAGDYVLGANVENASYPVTTCAERVALGRAVVDGYHLRGGFRAVAVATDAGEPASPCGMCRQFIREFCDLSVPIIMFDKDTNYVVMKLEELLPLSFGPDNLGAPDPAKPKPSAGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEA8</accession>
    <name>Q2HEA8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA damage checkpoint protein rad24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_01446</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001220666.1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="306901.Q2HEA8"/>
    <dbReference type="GeneID" id="4387033"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01446"/>
    <dbReference type="eggNOG" id="KOG0841">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058290_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HEA8"/>
    <dbReference type="OMA" id="KGCQLAR"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11309">
        <property type="entry name" value="14-3-3_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="14-3-3 protein epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="5">
        <location>
            <begin position="3"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="233"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ93211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="264" mass="29571" checksum="7DE7F505B002DFF4" modified="2006-03-21" version="1">MGHEDAVYLAKLAEQAERYEEMVENMKIVASEDRDLTVEERNLLSVAYKNVIGARRASWRIVTSIEQKEESKGNSTQVDLIKEYRQKIEAELAKICEDILSVLDQHLIPSAKSGESKVFYHKMKGDYHRYLAEFAVGDKRKDSADKSLEAYKAATEVAQTELPPTHPIRLGLALNFSVFYYEILNAPDQACHLAKQAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSSEAEAPAATGSAEAPTQEEPKPEAAAEEPKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEC1</accession>
    <name>Q2HEC1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="12">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CHGG_01433</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="12"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220654.1">
        <property type="nucleotide sequence ID" value="XM_001220653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEC1"/>
    <dbReference type="FunCoup" id="Q2HEC1">
        <property type="interactions" value="847"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HEC1"/>
    <dbReference type="GeneID" id="4387045"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01433"/>
    <dbReference type="eggNOG" id="KOG0216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_5_1_1"/>
    <dbReference type="InParanoid" id="Q2HEC1"/>
    <dbReference type="OMA" id="FFGVVHY"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="16">
        <location>
            <begin position="92"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="15">
        <location>
            <begin position="156"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="443"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="18">
        <location>
            <begin position="548"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="13">
        <location>
            <begin position="655"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="14">
        <location>
            <begin position="1033"/>
            <end position="1101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAQ93198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1188" mass="132469" checksum="C6A47B1E0B865F9B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEF0</accession>
    <name>Q2HEF0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220625.1">
        <property type="nucleotide sequence ID" value="XM_001220624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEF0"/>
    <dbReference type="GeneID" id="4387727"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01404"/>
    <dbReference type="eggNOG" id="ENOG502S7E3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103432_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HEF0"/>
    <dbReference type="OMA" id="AFYGYAM"/>
    <dbReference type="OrthoDB" id="2550114at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39605">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39605:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="193" mass="20039" checksum="725B78D60CD1C368" modified="2006-03-21" version="1">MDSVSTYSVASLAWLATQAIPLIIWPSLISTLLQVDSPPQQGAQYGAAYGSLEQYFARSLGLAQLALGSLLLILSGALPLDSVADQATPATTTATPTGSASAAVLVTALYHAATASYAYARYAGTGGRQFAYLCGCLGGSGLAAFGLWVLLFAGDANRRVSRRTGADKSTSGWPFRNAEADKKRGKGGARRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEG1</accession>
    <name>Q2HEG1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220614.1">
        <property type="nucleotide sequence ID" value="XM_001220613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEG1"/>
    <dbReference type="GeneID" id="4387065"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01393"/>
    <dbReference type="eggNOG" id="ENOG502RJWF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093929_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HEG1"/>
    <dbReference type="OMA" id="YEPIFTI"/>
    <dbReference type="OrthoDB" id="5199481at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209251" evidence="2">
        <location>
            <begin position="18"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="202" mass="21452" checksum="A9064CC4329DE5D9" modified="2006-03-21" version="1">MRLQAITLSLLAATGLATPIRRDVSQAVYTLRLTSPVKSLDGLYLTTTPQSDTDDTSTLGVSTSTTTSPATQPVRFYPVHNPDTDLDELRRSSDTVGGGGALAVVGANGLLDFAALADPEAVQAPDGTTVDWTSFRLGAEKKEGGGGAVEYVGKGGVAEGRWVAFPVGGEGERWSVKWRDVSAWTTENYMPVEVVYELVKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HF63</accession>
    <name>Q2HF63_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ERAP1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220362.1">
        <property type="nucleotide sequence ID" value="XM_001220361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HF63"/>
    <dbReference type="STRING" id="306901.Q2HF63"/>
    <dbReference type="GeneID" id="4388062"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01141"/>
    <dbReference type="eggNOG" id="KOG1046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1610555_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HF63"/>
    <dbReference type="OMA" id="RWVENIK"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ92906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="165" mass="18942" checksum="A195BB3D31987D30" modified="2006-03-21" version="1">MRIAGDENAISPHLRWEVFVIVVAHGGRAKAEALLSLWKTSSNSDERYLALECLGRASDASLVKWILGLVFTEDIKDQDIYLLLWLMGSSAHGTTELWEWAKLNWGRLEDVKTYFSGCDTRQYEQALAQKLERIETRVRWAARDVGNVAPWLKTHGYLEECQWSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFH4</accession>
    <name>Q2HFH4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyl transferase family 17 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220251.1">
        <property type="nucleotide sequence ID" value="XM_001220250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFH4"/>
    <dbReference type="STRING" id="306901.Q2HFH4"/>
    <dbReference type="GeneID" id="4387139"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01030"/>
    <dbReference type="eggNOG" id="ENOG502QUBY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038606_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HFH4"/>
    <dbReference type="OrthoDB" id="6474464at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003830">
        <property type="term" value="F:beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006813">
        <property type="entry name" value="Glyco_trans_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224:SF0">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN BETA-1,4-N-ACETYLGLUCOSAMINYL-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04724">
        <property type="entry name" value="Glyco_transf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209292" description="Glycosyl transferase family 17 protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="34567" checksum="66DB3F8F8A9564A6" modified="2006-03-21" version="1">MSRRTRQLWRWVRVTAVLGVIWLVLSVAHGNGSDSNPLAPTWASRDDNPLDMCRRYGWKPFRPKDPSKPRKVYDLMMFNTELDHLEIRLNSTWDEVDYFVIVEGSKTFTNHAKPLTLKRHLPDFKPYHSKIIYHEIVYPPNFKPRTTWDMEDLQRNSMLTQVFPHLSGRQAPQHGDVLVVSDVDEVPRPETLRVLRACAFPRRLTLSSRFYYYSFQWLHRGPEWPHPQATFYQGMLKTLRPNDLRIADGGMWPFREKGYSLSQHGNSQHTSVAGSSVWATTWTWNGRFEVVIKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFS4</accession>
    <name>Q2HFS4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1275 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220151.1">
        <property type="nucleotide sequence ID" value="XM_001220150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFS4"/>
    <dbReference type="STRING" id="306901.Q2HFS4"/>
    <dbReference type="GeneID" id="4387994"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00930"/>
    <dbReference type="eggNOG" id="ENOG502SAKB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061825_1_2_1"/>
    <dbReference type="InParanoid" id="Q2HFS4"/>
    <dbReference type="OMA" id="TTVWCEL"/>
    <dbReference type="OrthoDB" id="5223589at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF2">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ92695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="30592" checksum="CF9BF701BC8D6869" modified="2006-03-21" version="1">MTQEKESTPSTPSSGGVLESQGLKSPNRQPSTRSRAWKHLNENVCASALAELELLILTFCIGLQDAVSFPDFHCFASNQTGNTVFLVLAIVLPEADGDMFYTANIGIALGFFLAAAWLTGQLGHIVGARRRCWLVLCNLLQTALVFAAAGLQYAHRSPTTGRLDLDGARAPSTLWAIGLLATAAGSQVVQARSLRVTEITTAMATAAWVDLMIDPNLYARSNRGRNRRLGFLAALVLGTLAGAFIFRRVGSPAALVVSAAGKLLVTVMYLFNPADKPKAEESAEDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFY1</accession>
    <name>Q2HFY1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220094.1">
        <property type="nucleotide sequence ID" value="XM_001220093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFY1"/>
    <dbReference type="GeneID" id="4386979"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00873"/>
    <dbReference type="eggNOG" id="ENOG502RZF1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_689280_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HFY1"/>
    <dbReference type="OMA" id="FPPESSW"/>
    <dbReference type="OrthoDB" id="4179406at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="383" mass="42585" checksum="753DEA289C47D677" modified="2006-03-21" version="1">MARTTRSSVKREFPPESSWRMVEGGENDSFDTSILHDDDIDFIGSSGSQPVGSQQSFSIGGSSQPWSIGGSQEDSIENFLSKAEDDEQVLLRSPFRPSVPKAVRDTSRENLRRRSPEPELEPQFYMPKVDVVSPRRDSTRSSTTIRASVPPPTPPKLRRRPGVVPESPARRRHVRDDEKIPVGERAGLDGTGGRASVSLPEHGEQVALHISIRDLRTVVRYSSLTSKEELILEFDGFIDTAQTVTSVLQSPPSFRNVQGRKDDILWTLWTLVGANNRRLSNYNSQLALLKQVDGQRSDAVQLVNELIVELEKIQASLGDLKGRVSEAGLLRAQAEVPLSVHIETINKGVERLEAARSRIRSIEDERIKEVLARGKGEEKLIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGC3</accession>
    <name>Q2HGC3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_00731</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219952.1">
        <property type="nucleotide sequence ID" value="XM_001219951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGC3"/>
    <dbReference type="FunCoup" id="Q2HGC3">
        <property type="interactions" value="365"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HGC3"/>
    <dbReference type="GeneID" id="4386767"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00731"/>
    <dbReference type="eggNOG" id="KOG2324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016739_2_2_1"/>
    <dbReference type="InParanoid" id="Q2HGC3"/>
    <dbReference type="OMA" id="NCDYAAN"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050062">
        <property type="entry name" value="Pro-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753:SF2">
        <property type="entry name" value="PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="66"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="332"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ92496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="562" mass="62113" checksum="AA41E63C44536C66" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH33</accession>
    <name>Q2HH33_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_00471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219692.1">
        <property type="nucleotide sequence ID" value="XM_001219691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH33"/>
    <dbReference type="GeneID" id="4388028"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00471"/>
    <dbReference type="HOGENOM" id="CLU_2527247_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HH33"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ92236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="84" mass="9116" checksum="F2CB5CD6D6FC9152" modified="2006-03-21" version="1">MHKSARQSRGAWSRRRAVGFDGLHGDILDGVMGLMVFHKSMCDDESLGTIGSIVRQNLSAGKDIRLERGQELVLPAVGRRASPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH45</accession>
    <name>Q2HH45_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Nucleolar essential protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_00459</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219680.1">
        <property type="nucleotide sequence ID" value="XM_001219679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH45"/>
    <dbReference type="FunCoup" id="Q2HH45">
        <property type="interactions" value="839"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HH45"/>
    <dbReference type="GeneID" id="4387579"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00459"/>
    <dbReference type="eggNOG" id="KOG3073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055846_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HH45"/>
    <dbReference type="OMA" id="VHNTFEL"/>
    <dbReference type="OrthoDB" id="269804at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005880">
        <property type="term" value="C:nuclear microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000003">
        <property type="entry name" value="Ribosomal RNA small subunit methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ92224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="27739" checksum="D1BE0A173AE3B58A" modified="2006-03-21" version="1">MERTQSLPPPELPQLVAEQHAPIPPTDKDSKRLIVVLSNASLETYKASHGGVSRMGVQREEKYSLLNSDEHIGVMRKMNRDISDARPDITHQCLLTLLDSPINKAGKLQIYIQTAKGVLIEVSPSVRIPRTFKRFAGLMVQLLHRLSIKGTNSQEKLLKVIQNPITDHLPPNCRKITLSFDAPMVRVRDYIDTLGTNESICVFVGAMAKGADNFADAYVDEKISISNFSLSASVACSKFCHAAEDSWDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHA3</accession>
    <name>Q2HHA3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 18">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CHGG_00401</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17 18">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18 19">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="5 18"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219622.1">
        <property type="nucleotide sequence ID" value="XM_001219621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHA3"/>
    <dbReference type="FunCoup" id="Q2HHA3">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HHA3"/>
    <dbReference type="GeneID" id="4387318"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00401"/>
    <dbReference type="eggNOG" id="ENOG502QPJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049944_5_1_1"/>
    <dbReference type="InParanoid" id="Q2HHA3"/>
    <dbReference type="OMA" id="HGCGMIS"/>
    <dbReference type="OrthoDB" id="448573at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
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        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF61">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000852">
        <property type="entry name" value="Phosphatidylserine_synth_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18 20" id="KW-0472">Membrane</keyword>
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    <keyword evidence="15 18" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EAQ92166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="243" mass="26177" checksum="44DD6EC2703326D5" modified="2006-03-21" version="1">MSKRTSASAANGVASKEGARLDLPTSDKQKILLSTDAGHFSLIRALHLADLITEMNGLCGILSVFSSMRYCVGDSAQHGNLWAALSLLPFGLFFDFLDGKVARWRKKSSMMGQELDSLADLISFGVAPAAVAFAIGIRTPLDHLCLGFFVLCGLTRLARFNVTAAAIPKDATGKARYFEGTPIPTTLGLDALMAWWLSNGWIHDALPGGVWFAGSAFELHPVVLLFMVHGCLMTSRTIHIPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHQ5</accession>
    <name>Q2HHQ5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="105" mass="11291" checksum="18B1D74A694E6C4E" modified="2006-03-21" version="1">MSVNLARGLGTSFDALKMGNSRPRLSKHGRPPGGDEIRMGGTTRVEMIGNGYGFVRGYWAGVAAAESKESGGNRVMTELVRTWFIALTAWVGRFCGGVPWVDEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHS1</accession>
    <name>Q2HHS1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_00233</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
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            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001219453.1"/>
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    <dbReference type="STRING" id="306901.Q2HHS1"/>
    <dbReference type="GeneID" id="4388261"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00233"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001887_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HHS1"/>
    <dbReference type="OMA" id="WRIAAVE"/>
    <dbReference type="OrthoDB" id="4589912at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052391">
        <property type="entry name" value="E3_Ligase-Neurotoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24133">
        <property type="entry name" value="ANKYRIN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24133:SF40">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209188" evidence="4">
        <location>
            <begin position="22"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="856"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="889"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1104"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="616"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="715"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="616"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="718"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ91998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1158" mass="126488" checksum="AC062FFC10688882" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-02-10" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM53</accession>
    <name>EIF3B_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Eukaryotic translation initiation factor 3 subunit B</fullName>
            <shortName evidence="1">eIF3b</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Eukaryotic translation initiation factor 3 90 kDa subunit homolog</fullName>
            <shortName evidence="1">eIF3 p90</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Translation initiation factor eIF3 p90 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">PRT1</name>
        <name type="ORF">CHGG_10951</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-3 subunit B family.</text>
    </comment>
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        <property type="protein sequence ID" value="EAQ83133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226218.1">
        <property type="nucleotide sequence ID" value="XM_001226217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GM53"/>
    <dbReference type="SMR" id="Q2GM53"/>
    <dbReference type="FunCoup" id="Q2GM53">
        <property type="interactions" value="1187"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GM53"/>
    <dbReference type="GeneID" id="4397283"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10951"/>
    <dbReference type="eggNOG" id="KOG2314">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011152_4_0_1"/>
    <dbReference type="InParanoid" id="Q2GM53"/>
    <dbReference type="OMA" id="LWGGPQF"/>
    <dbReference type="OrthoDB" id="10250414at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12278">
        <property type="entry name" value="RRM_eIF3B"/>
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    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000419">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036424">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000363815" description="Eukaryotic translation initiation factor 3 subunit B">
        <location>
            <begin position="1"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="42"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="195"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="236"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3">
        <location>
            <begin position="309"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4">
        <location>
            <begin position="519"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03001"/>
        </source>
    </evidence>
    <sequence length="750" mass="85884" checksum="31EC746F41B4F583" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMC0</accession>
    <name>Q2GMC0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226151.1">
        <property type="nucleotide sequence ID" value="XM_001226150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMC0"/>
    <dbReference type="STRING" id="306901.Q2GMC0"/>
    <dbReference type="GeneID" id="4397345"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10884"/>
    <dbReference type="eggNOG" id="ENOG502RUPB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_438704_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GMC0"/>
    <dbReference type="OrthoDB" id="3598281at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681:SF3">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="623" mass="68780" checksum="12528015D6BB89BE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNB0</accession>
    <name>Q2GNB0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84140.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="XP_001228471.1">
        <property type="nucleotide sequence ID" value="XM_001228470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNB0"/>
    <dbReference type="GeneID" id="4396005"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10544"/>
    <dbReference type="HOGENOM" id="CLU_2158089_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNB0"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="111" mass="9871" checksum="842F48D3F3157BE6" modified="2006-03-21" version="1">MVMVINEPASNPNRTLDSFKTLAATAQGVTPGGGAGGAAGGAGGGAAGGAGGSTGGDQTGSTGGTTPTGTEDAAQATISTAGAGVLTVPGGVRAGGGGCGSACSLRRGPSH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-03" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNN3</accession>
    <name>RRG9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>Required for respiratory growth protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RRG9</name>
        <name type="ORF">CHGG_10421</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for respiratory activity and maintenance and expression of the mitochondrial genome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RRG9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228348.1">
        <property type="nucleotide sequence ID" value="XM_001228347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNN3"/>
    <dbReference type="SMR" id="Q2GNN3"/>
    <dbReference type="STRING" id="306901.Q2GNN3"/>
    <dbReference type="GeneID" id="4396463"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10421"/>
    <dbReference type="eggNOG" id="ENOG502S7IA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047598_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNN3"/>
    <dbReference type="OMA" id="MSCSCNT"/>
    <dbReference type="OrthoDB" id="5578174at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010487">
        <property type="entry name" value="NGRN/Rrg9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475:SF3">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06413">
        <property type="entry name" value="Neugrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end status="unknown"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000407944" description="Required for respiratory growth protein 9, mitochondrial">
        <location>
            <begin status="unknown"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="288"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="328" mass="37314" checksum="97CB1AB59DD9873B" modified="2006-03-21" version="1" precursor="true">MSISYVARIINGNSEVGILDQVREPTLKIFVRTIAQIHVPLRTTTPRATQYRALSTQPNRACTQQTSSILATTPRALHTSCARDRDWQAPKPFKRRGGGRSVQNNPLASSHASEPVANDPFRHLSQNDYARPTARPQAYRSKTGDSGGREQRYKPAGGARKPRRPNPESNTQGGNWAEPKTKEPWRIQKEALAKKFPEGWKPRKKLSPDALVGIRMLHQQFPDEYTTETLAQKFEVSPEAIRRILKAKWVADPETEVERQARWHNRGKQVWTKWAALGKKPPRKWRAEGIVRDPIWNEPRGPNHKDKAARAEAQRREAQRRLASGMMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPB0</accession>
    <name>Q2GPB0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_10194</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228121.1">
        <property type="nucleotide sequence ID" value="XM_001228120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPB0"/>
    <dbReference type="STRING" id="306901.Q2GPB0"/>
    <dbReference type="GeneID" id="4396119"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10194"/>
    <dbReference type="eggNOG" id="KOG3607">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012383_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GPB0"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04271">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034028">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208310" description="Peptidase M12B domain-containing protein" evidence="4">
        <location>
            <begin position="24"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="593"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="6">
        <location>
            <begin position="245"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="5">
        <location>
            <begin position="387"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="623"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="633"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="665"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="689"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ83790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="713" mass="75278" checksum="C5B9A2B19EF61303" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQ59</accession>
    <name>Q2GQ59_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_09895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227822.1">
        <property type="nucleotide sequence ID" value="XM_001227821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQ59"/>
    <dbReference type="GeneID" id="4396784"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09895"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001613_8_0_1"/>
    <dbReference type="InParanoid" id="Q2GQ59"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
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            <end position="602"/>
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        </source>
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</entry>
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                <person name="Untereiner W.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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            <end position="243"/>
        </location>
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        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="383" mass="41612" checksum="D1752565D6A09848" modified="2006-03-21" version="1">MSGATNKPDEAILPSEASLTNDTLVTGDTNLADEAWVIVPDEATPQSPTSLASTTSADDQAISPSDSISSGVVTMIAQTTLSDENTTMPSGTTQSDGATQANKKIKNTKPNATTPANITVQPSNINTQMPAAKGTFPLFPSLPREIRAQIWELCLPRRFIPLSTLVVGRDHRNAAAETDPTQPGCDDPAVQTLIDSVMTRACRIAQVCRESRAVALSQRESTAELGLLWLGRENWFDRRTDMLFVDCDVRERYREIWEELRAKVVVGDWEEQGYGAGGAGGVCVALCKHMVMRWTPTDPPAPVLPVMETGVTTRRGIRQKSWPVVRERLPPIPGQKSPAGSGKFGLFDEECVTLLDVSEGKQGGVVEWVKELLSETFCMELSL</sequence>
</entry>
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        </source>
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    </dbReference>
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        <source>
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        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="643" mass="72114" checksum="C40310565284A322" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GR51</accession>
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        </submittedName>
    </protein>
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        <lineage>
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        </lineage>
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            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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    <dbReference type="HOGENOM" id="CLU_771598_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GR51"/>
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        <location>
            <begin position="77"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="359"/>
        </location>
    </feature>
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        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85539.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="359" mass="39311" checksum="974FA2DC665BC5CD" modified="2006-03-21" version="1">MVFAATTSTRQAILRIQGLISTLVSMRRKSVTKARGVGMTRVWYSSGLAMAARRRDVRARHKRLSWQASQSAHWWPASRNSHVPESRRAKRVVNGGAGTKASAMGRSSSVGRRSRDWQSWLGGSGTGAAGPPRETGDVIGGGQESSAQGAGAPSEPHQRSSQTVVIHAMGCQEEKLEIGRGKTAAWALQPALFGGRSKRVRLWARTPCRLADIAPVWSFLLHALPQILPQCSIGHGNPRPDLGAAVVVRFGPLKVAHSGSGMETGRLPTAAEPGRTQRSRSRFSRCYSFIWFAGWRVGRQQRGELPNQHQSERRSNPPSEVVVTARTDTRVFVMRKGRHAGGQKGTKHQASRCRSRRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRB3</accession>
    <name>Q2GRB3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_09491</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227418.1">
        <property type="nucleotide sequence ID" value="XM_001227417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRB3"/>
    <dbReference type="GeneID" id="4395668"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09491"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_618210_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRB3"/>
    <dbReference type="OrthoDB" id="4580177at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="344"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="352"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ85477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="443" mass="46919" checksum="112038554569AFD3" modified="2006-03-21" version="1">MVRVLVREGGADVDAVFEVAETGEREGKGSTRGMEGGLKGLRGKTRRSVSGESLRREKGPRHPVSALHLAYNNYACAQVLLECGANVGARDGYGRTPLYWAAEAGQADVVRLLIGAGADVNAASDDGVTPLSAVVASFENEQGSHGHTETLRLLLQGGAPSKSGSHSQDEGLWREKLAAFIMWHEMREGFSEDEGVVLGEKYLIDTVAPARKGVVIRAQILPGGVPPAVFVFGCPRPMDIDHTPDAAVVSAHALAGRHSMASSLRHAILLTGRASEPNDWLGPVEVATQTAQAAVSVSWSSPDVLLQAHPHATRRLPTGDLQNRPASVRLVRHFQVVLISDLRKSTGEPGPSSYNSLAEATNQGTPRDTPPPPWLSDGPIPVMSARGATYVGWTLANLRAVGLHAAEVHDSGRGEEGLMPDSYATHSRKGLEGQLAFVLGLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRH0</accession>
    <name>Q2GRH0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_09434</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227361.1">
        <property type="nucleotide sequence ID" value="XM_001227360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRH0"/>
    <dbReference type="GeneID" id="4395063"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09434"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_1_1"/>
    <dbReference type="InParanoid" id="Q2GRH0"/>
    <dbReference type="OMA" id="ITARRSH"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF115">
        <property type="entry name" value="DEHYDROGENASE XPTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208377" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="549"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="592"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ85420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="617" mass="65852" checksum="49E51189920EEDC1" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRK7</accession>
    <name>Q2GRK7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450 monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_09397</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227324.1">
        <property type="nucleotide sequence ID" value="XM_001227323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRK7"/>
    <dbReference type="STRING" id="306901.Q2GRK7"/>
    <dbReference type="GeneID" id="4394930"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09397"/>
    <dbReference type="eggNOG" id="KOG0159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022195_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GRK7"/>
    <dbReference type="OMA" id="HEFIFPN"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF6">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AN1598-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ85383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="59076" checksum="E318F1AED29409B4" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRU9</accession>
    <name>Q2GRU9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_09305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227232.1">
        <property type="nucleotide sequence ID" value="XM_001227231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRU9"/>
    <dbReference type="STRING" id="306901.Q2GRU9"/>
    <dbReference type="GeneID" id="4394857"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09305"/>
    <dbReference type="eggNOG" id="ENOG502S4VH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042937_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRU9"/>
    <dbReference type="OMA" id="FEGRERW"/>
    <dbReference type="OrthoDB" id="6508832at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20273">
        <property type="entry name" value="Complex1_LYR_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046896">
        <property type="entry name" value="Cup1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ85291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="407" mass="45800" checksum="548E8BC0D7097A1D" modified="2006-03-21" version="1">MPSLFAPARSSQHRTACFALYRSLLRQGLRVPLPDELSTASPLGPANPIQTLVRNAFHRNKRDTSPRLVVSALKNGYRYLTLLSRAADPTSPEHTEALIFLRKNQARVVALKAKAAEAAAKRISTAPIEGHAPLLKRVSADGEPPVYEPALPPRPLEAFKTGVRKPPTLSATLGVPFLRFWKPQPRFLERVIRQKSQRRAKRITRIIEMQGGEEMESAIEEDQWERLVEKMLAEKEGRPVLPMTRGENTYKQSLWDAISYLSYVSEIERVDLQARGEAMWKIVLTEQEMALQEEKDRLVREGREGEEPKVRVWRRPVHKKVPRTDVNERNKPVEELKLSIRRVAVRKASPKAGSDGNARGGTKPAEPSTESGSSTKSEAPTHTKPSMETRSSMETRPPMGTEPPKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GS17</accession>
    <name>Q2GS17_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL6 alpha-beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_09237</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227164.1">
        <property type="nucleotide sequence ID" value="XM_001227163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GS17"/>
    <dbReference type="FunCoup" id="Q2GS17">
        <property type="interactions" value="592"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GS17"/>
    <dbReference type="GeneID" id="4395720"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09237"/>
    <dbReference type="eggNOG" id="KOG3254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065464_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GS17"/>
    <dbReference type="OMA" id="RERHGLC"/>
    <dbReference type="OrthoDB" id="540873at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_uL6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_uL6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="5">
        <location>
            <begin position="138"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ85223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="234" mass="26260" checksum="02915B83BD9934FB" modified="2006-03-21" version="1">MLAPRTGRQALRRALASNPSPTITLPGFLVPAFQTRRTFSATTHRPSKLGRTPLSVPPGVELTISDPFIKKDMTSYLKTHTRTITVTGPLGNLELEIPDYININHDAAARKVELSVKDRDETNQNRMWGHTAVLRLVGIGYRATIEPRPAKAEYPDQQFVCLKLGFSHPVEMGLPKGMKASAPQPTRVLLEGIDKEQIMQFAADIRRWRVPEPYKGKGIFINDETIKLKQKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSY5</accession>
    <name>Q2GSY5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome c oxidase assembly protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_08919</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:63388"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:61715"/>
            <dbReference type="EC" id="1.17.99.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:63389"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226846.1">
        <property type="nucleotide sequence ID" value="XM_001226845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSY5"/>
    <dbReference type="FunCoup" id="Q2GSY5">
        <property type="interactions" value="765"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GSY5"/>
    <dbReference type="GeneID" id="4395208"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08919"/>
    <dbReference type="eggNOG" id="KOG2725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017627_4_2_1"/>
    <dbReference type="InParanoid" id="Q2GSY5"/>
    <dbReference type="OMA" id="AFVCYSW"/>
    <dbReference type="OrthoDB" id="1726137at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120547">
        <property type="term" value="F:heme A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01665">
        <property type="entry name" value="HemeA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="49"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ84905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="469" mass="51354" checksum="EDB39FE5A4112163" modified="2006-03-21" version="1">MAFIQLGLRRATASLPRVPFPCSPCLRQQVPVPPARVLKLLGATRSYASRTTAGSKSPIGSLSRNITKAARPAPQSASSQSSGKSSSFPKTNAKVVGYWLMGSAVSVFGIVVFGGLTRLTESGLSITEWRPVTGSLPPMSDADWQSEFDKYRASPEFKLINPHMDLAEFKKIYFMEWAHRLWGRVIGLTFVLPTIYFIARRRVTARMAVNLVGISALIGFQGFIGWWMVKSGLKDDLFAPGSHPRVSQYRLTAHLAAAFVCYSWMLVSGLGVLRSHRLLRDPEAAVKTFAALKSPALRALRGSVAALTVLIFTTVLSGALVAGLDAGLIYNEFPMMGNGLTPPKSELFDKFYSRKEDESDLWWRNMLENPSLVQLDHRILATTTFTAVVALVAYSRTGRVKAAMPKDVRKGVMGLLHLALLQVSLGITTLMYMVPISLAAAHQAGALGLLTMAFGCWSPGCEFLRLRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTD6</accession>
    <name>Q2GTD6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_08768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226695.1">
        <property type="nucleotide sequence ID" value="XM_001226694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTD6"/>
    <dbReference type="GeneID" id="4395742"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08768"/>
    <dbReference type="eggNOG" id="ENOG502RFXX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1713033_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTD6"/>
    <dbReference type="OrthoDB" id="1601230at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17556" checksum="FAB1CC3596CCDDB5" modified="2006-03-21" version="1">MGRRLQDFFFGVVYVSVILYTEHIVKGILSSDQIWPFGGGSFDDDSTPRKANRHLLFISFKLPVSPTMINVIRRRTIAFREICLKPDGKPYILSGRIAHGFVIEFTNPSDCWYFLHMDQAYKNFVESIDPTVDDFLTVAFSPGLGPGWLRLQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTU3</accession>
    <name>Q2GTU3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Right handed beta helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226538.1">
        <property type="nucleotide sequence ID" value="XM_001226537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTU3"/>
    <dbReference type="GeneID" id="4395795"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08611"/>
    <dbReference type="eggNOG" id="ENOG502R351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041546_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTU3"/>
    <dbReference type="OMA" id="DVCGTIN"/>
    <dbReference type="OrthoDB" id="5576103at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209002" description="Right handed beta helix domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="36809" checksum="EC1F357E10CACBBC" modified="2006-03-21" version="1">MAQFALSLLTAALALASAAQAQCGSGSPHATVTGSGSSFTAKKGSSNVYSGSDYRAAIQAALDSIGSGQRVAVMASGSIGASTITITSGKIFEGCGTINVGNKSGRGAIESTDTSDVQIPYLTMTGNPYFGLRFSGTRNLSLGKITMNLSGGLGIRFDRDRAANSNVKMDVITVTGAGSHAVETWNIDGLEINQVIARNVGESGLLLQATRNAHVGLVDGNNVAAGTGYATFRMANNNGQNANGNYNTNVYIDKVVSRGGGRGVFCVSQSGGVVIEQVDLADNGNNAILIENCYNVSIRGGKVNGGGEVRISARSEFPNTRDIWITLQVDNTSVRESPCGDNTNWTLSGNGKRTIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTU8</accession>
    <name>Q2GTU8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_08606</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226533.1">
        <property type="nucleotide sequence ID" value="XM_001226532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTU8"/>
    <dbReference type="STRING" id="306901.Q2GTU8"/>
    <dbReference type="ESTHER" id="chagb-q2gtu8">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="4395808"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08606"/>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_15_1_1"/>
    <dbReference type="InParanoid" id="Q2GTU8"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007319298" description="Carboxylesterase type B domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="40"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="681"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="714"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ84592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="743" mass="80376" checksum="485AD7E0E7765E99" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTX0</accession>
    <name>Q2GTX0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_08584</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226511.1">
        <property type="nucleotide sequence ID" value="XM_001226510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTX0"/>
    <dbReference type="GeneID" id="4394941"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08584"/>
    <dbReference type="eggNOG" id="ENOG502SS51">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054422_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTX0"/>
    <dbReference type="OMA" id="DFNRGLW"/>
    <dbReference type="OrthoDB" id="3547571at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208600" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ84570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="32526" checksum="24590CE98FE5B46F" modified="2006-03-21" version="1">MRLLIFSLVAGSLNSIKLVHALALITPAPPLPTTPPAQRRDTGPGTSTCGFLEGDPSKPFVAPQGFNCRLDTLNVYVAHTLLNRSSGRDGNASAKFCSMAVLIVNPGLSFDYIDCAQSPGEATYFLTATAFLDASAVIPSPSSSSPPPSSSLASSSSASSQSSSQPSSLSPSSPSRSVPSTVLSTTNSSPLSETPPPTPGLNSGNGGDGGSSTNNTGAIVGGVLGGLALVLGSAVALVYLLKHSRGRRAEHQADEGMDSSSETGGKHASGGWGPSELGDSRSIPRELDSRLVPGELPAGHTVARPAVPPVELPATPVLHEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU07</accession>
    <name>Q2GU07_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_08547</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226474.1">
        <property type="nucleotide sequence ID" value="XM_001226473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GU07"/>
    <dbReference type="GeneID" id="4395434"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08547"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="InParanoid" id="Q2GU07"/>
    <dbReference type="OMA" id="LQASENW"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF46">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G11830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="13"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ84533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="510" mass="56494" checksum="01DD8F2C398C6E87" modified="2006-03-21" version="1">MGLTKQVWYNWYTGLVAAGCMILLGYDSSVFNSVQASENWKSAMGNPDPYMVGLVNTVYTVGGIVTGWFFAGPTSDYFGRRFGMGLGCMITVVATFLQTFPPVKGTLACFMVGRVFIGVGTAFATTSGPVYIGEVTAPEIRGKVMSFWQMFFSVGSFIAYWINFACARNRTSLGHWDWKMVVIFQLMMPVIICAQLPFLPESPRWLIAKRNDYEGAKAALMRVRSTEEEVDAEILSIREAIAFEHETAPRKREAYLALIKDKAIRKRVILAFIINVGQQLTGQGTLNSYSSTIYQKVFNNVDTINLINALNGTLSIMFTLNATWTVDRFGRKWLFMVGAAGMAICTMLIGVVGLTTPDVNGTKTYGVGIGIATLAFAFAFFFKPSWGAVVWIYTAEIFPMHVRAQGTGMSVQMQGVANTIFQQFFPIFFKNEGLKVFFFFMTTNVLLILFTYFCLPETKNVTLEQMDVLFGDVDHVAKGAGFIDEPTAPVPLGDKPEAVALETVPKKESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUR3</accession>
    <name>Q2GUR3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ87038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225947.1">
        <property type="nucleotide sequence ID" value="XM_001225946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUR3"/>
    <dbReference type="GeneID" id="4394494"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08291"/>
    <dbReference type="eggNOG" id="ENOG502TA09">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_500571_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUR3"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="60199" checksum="FE67B5F77954E25F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUZ7</accession>
    <name>Q2GUZ7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225863.1">
        <property type="nucleotide sequence ID" value="XM_001225862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUZ7"/>
    <dbReference type="GeneID" id="4394561"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08207"/>
    <dbReference type="HOGENOM" id="CLU_2158088_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUZ7"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208655" evidence="1">
        <location>
            <begin position="17"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="111" mass="12011" checksum="89AFC3FC5966E579" modified="2006-03-21" version="1">MTLLIPLLCAPDLADCNLVMGYYNITVGPLPRYARDQRQLTRRGLSGYHLAQPGDLRRAGRRVLRWGAEARAAAKFSRPRNVRLPPSYPQACIIAAVNRAAQGGGGGGLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVY0</accession>
    <name>Q2GVY0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_07874</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225530.1">
        <property type="nucleotide sequence ID" value="XM_001225529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVY0"/>
    <dbReference type="STRING" id="306901.Q2GVY0"/>
    <dbReference type="GeneID" id="4393452"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07874"/>
    <dbReference type="eggNOG" id="KOG0897">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003143_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GVY0"/>
    <dbReference type="OMA" id="LVCHCKT"/>
    <dbReference type="OrthoDB" id="109543at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23802">
        <property type="entry name" value="UBCc_UBE2Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000107">
        <property type="entry name" value="Ubiquitin conjugating enzyme, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051838">
        <property type="entry name" value="ARTD_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21328">
        <property type="entry name" value="POLY ADP-RIBOSE POLYMERASE FAMILY, MEMBER PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="1056"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="686"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="965"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="695"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ86621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1252" mass="138062" checksum="27EB2734FBB17EFE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GW77</accession>
    <name>Q2GW77_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein sorting-associated protein 55</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_07777</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225433.1">
        <property type="nucleotide sequence ID" value="XM_001225432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GW77"/>
    <dbReference type="FunCoup" id="Q2GW77">
        <property type="interactions" value="470"/>
    </dbReference>
    <dbReference type="GeneID" id="4393695"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07777"/>
    <dbReference type="eggNOG" id="KOG2174">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134810_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GW77"/>
    <dbReference type="OMA" id="ICARCAN"/>
    <dbReference type="OrthoDB" id="14246at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034424">
        <property type="term" value="C:Vps55/Vps68 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF0">
        <property type="entry name" value="RH04491P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ86524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="13869" checksum="8DB57CC69D3D1399" modified="2006-03-21" version="1">MPAAGLKTIIALSFVLAVGFLLVILSCALWHSYYPLLVVGTYVLAPVPNWICSHCANPDDFVESSGAAVLDLGRFCTGFLVVMGIALPVLLAHSNLISIPAMVMSIIGGLLIYGTIISFTMFFQEEQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWP6</accession>
    <name>Q2GWP6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_07608</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225264.1">
        <property type="nucleotide sequence ID" value="XM_001225263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWP6"/>
    <dbReference type="STRING" id="306901.Q2GWP6"/>
    <dbReference type="GeneID" id="4394212"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07608"/>
    <dbReference type="eggNOG" id="KOG2307">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_653811_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWP6"/>
    <dbReference type="OrthoDB" id="332281at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="10">
        <location>
            <begin position="58"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="199"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ86355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="420" mass="44838" checksum="D88884D3288F06F8" modified="2006-03-21" version="1">MAQLAPPSPNSRPTSAYSYTPSQSYTLPRSPTNPNPPSDSDSNSDADSDLPLPFPAALSRADFLAPDFDAAAYLSALHTGGPASRHQTLEDLRAELRERSAAISAELLELVNANYTAFLGLGDGLKGGEDRVGDVRVALLGFRRAVEEIQGRVRERRVEVGRVNAEVAGVKTAVECGRRMLELDERVAGLERRLAIGSAGEGGKKGGGGEEEGGDWGDDFDSAGSEEEDEEEDGVELVSSSPAKLTALAKDGAEYNLVKCLCVAVIHIVDVRLQQGQERLDVIGQHLGGKSHLAHCQPHHTAAFPVLVRAYEFLNCRLEVGRNSLGLLAGHQTPGTEDFAEVGFLQCVLAVLVADKLVEWNVALPDALKKAFLSHCYGTKLLRLGHQGAVLGTDNADARVGFDRERKTNSVPNNGAAFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWS8</accession>
    <name>Q2GWS8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc finger double-stranded RNA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_07576</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IPP transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225232.1">
        <property type="nucleotide sequence ID" value="XM_001225231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWS8"/>
    <dbReference type="FunCoup" id="Q2GWS8">
        <property type="interactions" value="865"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GWS8"/>
    <dbReference type="GeneID" id="4393963"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07576"/>
    <dbReference type="eggNOG" id="KOG1384">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_790357_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWS8"/>
    <dbReference type="OMA" id="WGLHLKS"/>
    <dbReference type="OrthoDB" id="775260at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF89">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger double-stranded RNA binding" evidence="8">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ86323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="305" mass="35174" checksum="7D54CB789CDFE52F" modified="2006-03-21" version="1">MAEKWHPNDARKIRTSLEIYFATGRRASDIYAEQRTKKESKWASQNHARDHDLGEILMFWLYAQREVLNERLDKRVDRMVQNGLLGETAEVYDHLCQKLAAGETVDRSKGIWQSIGFRQFEPYLTAMKEDPDSPELDKLKLAGIEDTKSATRQYAKYQVRWMTMKTVASLQEERLLDRLYLLDSSDVQRWKAEVLDKGVELTRQFLAHEPLPLPAEVSEMAKEVLAGTVERSNRQDTPCRKTCEICKKTLLTEELWQAHITSRKHLKVVRGAKKRQLIPAHAVPSRALIATTPEPQDTAPTIDHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWZ6</accession>
    <name>Q2GWZ6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Benzoate 4-monooxygenase bphA</fullName>
            <ecNumber evidence="12">1.14.14.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Benzoate-para-hydroxylase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Cytochrome P450 monooxygenase cyp53A1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CHGG_07508</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>benzoate + reduced [NADPH--hemoprotein reductase] + O2 = 4-hydroxybenzoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18033"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16150"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.92"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.92" evidence="12"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225164.1">
        <property type="nucleotide sequence ID" value="XM_001225163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWZ6"/>
    <dbReference type="STRING" id="306901.Q2GWZ6"/>
    <dbReference type="GeneID" id="4394398"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07508"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="InParanoid" id="Q2GWZ6"/>
    <dbReference type="OMA" id="TYDMVRD"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018664">
        <property type="term" value="F:benzoate 4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000053">
        <property type="entry name" value="Cytochrome P450 benzoate 4-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF29">
        <property type="entry name" value="BENZOATE-PARA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 16 17" id="KW-0349">Heme</keyword>
    <keyword evidence="7 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAQ86255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="510" mass="57384" checksum="CACB37B98E83E072" modified="2006-03-21" version="1">MALINFILSPWAPAALLVAAVVYYVYPYFVTYRHLKHIPAPFPAQFSNWWLLLVARRGDRYDTVDKLHKKLGPVVRIQPNHVSLCNDEAIQIVYGHGNGFLKADFYDAFVSIQRGLFNTRDRAEHTRKRKIVSHTFSVKSVAQFEPYIHSNLELFVRQLDNLILRSNHPDGAAHLDCLNWFNYLAFDVIGDLAFGAPFGMLSSGADMAEVRASPDSPPIYLSAIEILNRRGEVSAALGSLPALKPFAKYFPDPFFTQGLQAVENLAGMAIARVKSRLENPPPAERKDLLQRLIDGRDEKGEPLGRQELTAEALTQLIAGSDTTSNSSCALLFHAVRTPGVIQKLQAELDAALPADLDVPTFDMVRDLPYLSAVVNETLRFHSTSGIGLPRQIPHDAPGIHYEGHYFPPGTVLSVPTYSIHHSKEIWGPDADEFKPERWEKLTPRQKNAFIPFSYGSRACVGRNVAEMEMKLIVATWSRRYHVTLRQDYMDTKEGFLRKPLGLEISLKRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX66</accession>
    <name>Q2GX66_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_07438</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225094.1">
        <property type="nucleotide sequence ID" value="XM_001225093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX66"/>
    <dbReference type="STRING" id="306901.Q2GX66"/>
    <dbReference type="GeneID" id="4393847"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07438"/>
    <dbReference type="eggNOG" id="KOG0496">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005732_2_1_1"/>
    <dbReference type="InParanoid" id="Q2GX66"/>
    <dbReference type="OMA" id="GGCPGDI"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.20.10:FF:000001">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Beta-galactosidase" evidence="9">
        <location>
            <begin position="339"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ86185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="765" mass="84737" checksum="CE75E658EBEAAF05" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXK5</accession>
    <name>Q2GXK5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_07299</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224955.1">
        <property type="nucleotide sequence ID" value="XM_001224954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXK5"/>
    <dbReference type="FunCoup" id="Q2GXK5">
        <property type="interactions" value="898"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GXK5"/>
    <dbReference type="GeneID" id="4394297"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07299"/>
    <dbReference type="eggNOG" id="KOG1596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059055_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GXK5"/>
    <dbReference type="OMA" id="WNPNKSK"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000056">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="24"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ86046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="311" mass="32306" checksum="1E54DDEEE152C99D" modified="2006-03-21" version="1">MGFDRGGRGGGRGGGFRGGDRGGRGGARGGGRGGFGGGRGGPGGRGGGRGGRGAPRGGGRGGRGGGPGGAKGGKKVIVEPHRHKGVFVARGGKEDLLATTNLVPGESVYGEKRISVENANKGDDAVATKTEYRLAAGILGGLETIYMKPGSKVLYLGAASGTSVSHVADIVGPTGAVYAVEFSHRSGRDLINMATRRTNVIPIVEDARKPMAYRMLLPMVDVVFADVAQPDQARIVGINAKLFLKQGGGLLISIKASCIDSTAPPEQVFASEVQKLREDKFFPKEQLTLEPYERDHAMVSCVYLQKEFEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXN8</accession>
    <name>Q2GXN8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcineurin subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Calcineurin regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Protein phosphatase 2B regulatory subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_07266</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Composed of a catalytic subunit (A) and a regulatory subunit (B).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224922.1">
        <property type="nucleotide sequence ID" value="XM_001224921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXN8"/>
    <dbReference type="FunCoup" id="Q2GXN8">
        <property type="interactions" value="764"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GXN8"/>
    <dbReference type="GeneID" id="4394585"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07266"/>
    <dbReference type="eggNOG" id="KOG0034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061288_10_1_1"/>
    <dbReference type="InParanoid" id="Q2GXN8"/>
    <dbReference type="OMA" id="DTNFDRD"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005955">
        <property type="term" value="C:calcineurin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004723">
        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071444">
        <property type="term" value="P:cellular response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006873">
        <property type="term" value="P:intracellular monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000047">
        <property type="entry name" value="Calcineurin subunit B type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01697">
        <property type="entry name" value="PARVALBUMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ86013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="174" mass="19506" checksum="111A97C7CA1781EE" modified="2006-03-21" version="1">MGNTTSAVLDNIVQGSNFDRDEVDRLRKRFMKLDKDNSGTIEREEFLSLPQISSNPLATRMIAIFDEDGGGDVDFQEFVSGLSAFSSKGNKEQKLQFAFKVYDIDRDGYISNGELFIVLKMMVGNNLKDQQLQQIVDKTIMEADLDGDGKISFEEFASIVANTDVSMSMTLDQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXN9</accession>
    <name>Q2GXN9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA helicase Pif1-like 2B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224921.1">
        <property type="nucleotide sequence ID" value="XM_001224920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXN9"/>
    <dbReference type="STRING" id="306901.Q2GXN9"/>
    <dbReference type="GeneID" id="4394584"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07265"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001613_3_0_1"/>
    <dbReference type="InParanoid" id="Q2GXN9"/>
    <dbReference type="OMA" id="CANINAP"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF6">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="1">
        <location>
            <begin position="144"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="339" mass="37639" checksum="EFAD5FA1973CA1D9" modified="2006-03-21" version="1">MNDLHLLPPVLNKALYSTRDDLKDIEMAGRNAYHSFDKSVFLTTIQRQQGEDQAPFRRALEELRKADVSVPSWELLVSRCSVKLSPKEVDSFADALRIYPTKAQVVKYNYQHMLGLDSPAIQVEAKHEGVGAEKVESSNAGNLAKRLPLCFGCRVMLTRNLWPDVGLVNGAQGRVYDISWKEGADVPRDPPEVIMVAFDDYNGPAFTMPNGEPLRSGEKLVVPILLVRQEFMIGANSCSREQFPLLVNYAITVHKSQGITLDKVVCDISAPEFASGLSYVAVSRVKTLGGLMFERPFDRSRIYRETPSRAMGLKLSDHATRQLQALDAVAGEAPSEESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXQ5</accession>
    <name>Q2GXQ5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_07249</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224905.1">
        <property type="nucleotide sequence ID" value="XM_001224904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXQ5"/>
    <dbReference type="FunCoup" id="Q2GXQ5">
        <property type="interactions" value="1266"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GXQ5"/>
    <dbReference type="MEROPS" id="C19.099"/>
    <dbReference type="GeneID" id="4394173"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07249"/>
    <dbReference type="eggNOG" id="KOG1863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003532_2_1_1"/>
    <dbReference type="InParanoid" id="Q2GXQ5"/>
    <dbReference type="OMA" id="HTAHHRF"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000011">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12436">
        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="9">
        <location>
            <begin position="90"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="247"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="801"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="810"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ85996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1143" mass="131023" checksum="7AF7178F9C3652D7" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXR1</accession>
    <name>Q2GXR1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224899.1">
        <property type="nucleotide sequence ID" value="XM_001224898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXR1"/>
    <dbReference type="GeneID" id="4393955"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07243"/>
    <dbReference type="eggNOG" id="ENOG502S9H1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120625_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GXR1"/>
    <dbReference type="OMA" id="YEAAEPY"/>
    <dbReference type="OrthoDB" id="2559326at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41800">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41800:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="115" mass="12224" checksum="C73F3D2D6256635C" modified="2006-03-21" version="1">MNTTNGEYRAGWAGARCVSARLEEQRKKKAMVDSLEYSENVPNRPLSSATMGGSNGGVASGGPARTDAVYSPSQESSSDPAPTRHAPATEGQRVAEKSKYEAAVPFNSRKGDRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GY20</accession>
    <name>Q2GY20_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_07134</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224790.1">
        <property type="nucleotide sequence ID" value="XM_001224789.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GY20"/>
    <dbReference type="GeneID" id="4393431"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07134"/>
    <dbReference type="eggNOG" id="KOG0245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_20_2_1"/>
    <dbReference type="InParanoid" id="Q2GY20"/>
    <dbReference type="OMA" id="IDRGAKC"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22705">
        <property type="entry name" value="FHA_KIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000021">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000047">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="13"/>
            <end position="362"/>
        </location>
    </feature>
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        <location>
            <begin position="619"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1323"/>
            <end position="1406"/>
        </location>
    </feature>
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            <begin position="1433"/>
            <end position="1479"/>
        </location>
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        <location>
            <begin position="752"/>
            <end position="829"/>
        </location>
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            <begin position="1457"/>
            <end position="1468"/>
        </location>
    </feature>
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        <location>
            <begin position="108"/>
            <end position="115"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ85881.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1588" mass="176351" checksum="A95A70ABD3301BAA" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYW2</accession>
    <name>Q2GYW2_CHAGB</name>
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        <recommendedName>
            <fullName evidence="5">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
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    </gene>
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        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
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            <taxon>Sordariomycetidae</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="427"/>
        </location>
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        </location>
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        </location>
    </feature>
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        </location>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="497" mass="55353" checksum="8A131E7108D8E42F" modified="2006-03-21" version="1">MSATAGGSSQDTIATSSQKPDKKHKRSKSDHKKKRAREEEDATVVEEIPRKSKKSRSADAEDRLAQPEHIEASADEAVKKKKKKQRAPEEVENGQDGIIAADEPKKERKKSKKRAKDVEQAGAEPMDVDLPETAPPEEAGGAERKRKDKKKSKKQELDRDDEMRDELPEADAGPQEKKKRKNKTTQEMQSTQESVAEVSSDSEFPFFTQTISLYVPFFPIGFDKPLTNVAAQHLDPLLNHYSPLLRGVLLSYSNLNLSDRPAKASITHPPTDETPALLHSIDEYAVGFGWLTFDAQLFVPSRGKWMEGVVQLQSEGHIGVVCWGKFNASIEAKRLPESWKWIDLAKGGARPNAFAASEENEGEQGGQEAEDVLDGEELQVVEQIHTTGYWVNGEGKKLSGKLRFRIKNFDVGLAGDYGYLSIEGTCLDDDAERALAAKERDMEKARRAKQNPGGLLRPLSRRVPEFSMTKFGREDQEEDDGQRAVLYKGSRPGTPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZ96</accession>
    <name>Q2GZ96_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_05150</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001224363.1"/>
    </dbReference>
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    <dbReference type="STRING" id="306901.Q2GZ96"/>
    <dbReference type="GeneID" id="4393064"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05150"/>
    <dbReference type="eggNOG" id="ENOG502T7VU">
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    </dbReference>
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    <dbReference type="InParanoid" id="Q2GZ96"/>
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    <dbReference type="OrthoDB" id="3350591at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ88531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="330" mass="37392" checksum="4B5F2C8B6EAD3237" modified="2006-03-21" version="1">MATNEPSEHFSVFDQLRPGWLPLLNDLVLVRGNPEEDLESMIATLYKEYLLSDDDGAPAAFARRFDDLYGEIYEPKFNGFNGKKRGWTGYLAVFYETVFSVAVAMDYDEPKQVKVIQLLSELRKLPTHAVKIFVQGEFAWIDSEIWTRDPLFPWALHEHDPGSMTVKDAETLNSQKDIDEFEDHFAAYLSYQTFSARCTAAGLDKGDLFRFESPGSYISALLQSDGELLDCEIVVIAQWILIAGDEIHAECVRKQLPRPARRTAWDGWYDGNGPVIWKQWGDKLAEFAAGLEGGGNPGFRLFENHRDLLTGMLVKARDKIIALEPGLFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZD0</accession>
    <name>Q2GZD0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001224329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZD0"/>
    <dbReference type="GeneID" id="4392167"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05116"/>
    <dbReference type="eggNOG" id="ENOG502SAYW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_5_1"/>
    <dbReference type="InParanoid" id="Q2GZD0"/>
    <dbReference type="OMA" id="EIMTNHI"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051604">
        <property type="entry name" value="Ergot_Alk_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162:SF1">
        <property type="entry name" value="PRESTALK A DIFFERENTIATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="298" mass="32171" checksum="0E5593B2976156E5" modified="2006-03-21" version="1">MQITVVPASPRTGQAAIRTLLADASNPTIKGYYRDLAKVPAEFKSNPRFEAVQGDVDDGATLDFSGSDAVFHITPPLYENTDVVERARLVSENVKAAIKKASVKRLVLVSSMGAQYGHGTGEILSNHEAEVVLQNAAPEVVFVRCGFFMENWGMGLETLAEGFLYTTLTPIDHPLPMIAVKDIGTICAAEVLATGTPLPANPHIFELHGPRPYTASEVHKLFEEATGKSIELRPVPKEGLDAFYAAVFPPLVAGYYAEMNKSYLPGGILDVNPEPTEGKTRYGTTELREVVEKLVAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZF4</accession>
    <name>Q2GZF4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein BIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224306.1">
        <property type="nucleotide sequence ID" value="XM_001224305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZF4"/>
    <dbReference type="STRING" id="306901.Q2GZF4"/>
    <dbReference type="GeneID" id="4391960"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05092"/>
    <dbReference type="eggNOG" id="ENOG502S2FQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050091_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZF4"/>
    <dbReference type="OMA" id="SGIAVCY"/>
    <dbReference type="OrthoDB" id="2596908at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208771" description="Protein BIG1" evidence="2">
        <location>
            <begin position="19"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ88473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="34942" checksum="47F8351192912A2A" modified="2006-03-21" version="1">MLWQRTLAASFLATGAQAGIGSLVAEGFSRNSEGVERRLEDMARANLRARGFLETRQSDGLSNDTPLKSDGSLDMEAWNTAVNTACRAALQNLNVASNPSGTCVCYNLPLLNNSTGTFEADLRLFQLSEPTGDFQGIPQESIEVELSYNGASVSEVNQQPVKRVKARQANNTGELPLLQSYLFIGQVDQDQMSGGVNVDKLQALVMPIVTLKATNGNGQSVNTVVSSNEAAFVAGEFSKDEVMSNYRMAELAVEAELAALKNGTVAFVLPGIQLMIFPIGLIITSVWLVLGLTAYGMGTYARYNFREAHRRRMAVASKGGMSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZJ8</accession>
    <name>Q2GZJ8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_05048</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224262.1">
        <property type="nucleotide sequence ID" value="XM_001224261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZJ8"/>
    <dbReference type="GeneID" id="4392752"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05048"/>
    <dbReference type="eggNOG" id="KOG0768">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_3_0_1"/>
    <dbReference type="InParanoid" id="Q2GZJ8"/>
    <dbReference type="OMA" id="DIWIAGA"/>
    <dbReference type="OrthoDB" id="250329at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="30"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="124"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="257"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ88429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="38026" checksum="13918F5EE0B2C2B1" modified="2006-03-21" version="1">MDSSITAMTSWGMARIYWSSINTYPAITLGSMKYWRWAGAVAAFTVDLLVYPLDTIKTRYQSQGYLGLKNNLSSTKGTPYTALRGLYQGIGSVVLATLPAAAVFFASYESTKPLLRHILPNAVPGPVIHAFASAGAEMASCLVLTPAEVIKQNAQVLQRSGSSSLGQSSSLQALHMLRRNGAGVTRTLWRGYTTLLARNLPYTAIQFPTFEYLRAWIWRQRRQGHHSEKASWTTPETTDGGMSVATHDSSFRPLLAETGLVTASAAAISGSFAAAITTPADVVKTRVMLGNRNDPQGPSGVVEIVRIVLRESGIRGLFRGGSLRAAWAALGSGLYLGSYELTKVWLKHRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0D9</accession>
    <name>Q2H0D9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_04757</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223971.1">
        <property type="nucleotide sequence ID" value="XM_001223970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0D9"/>
    <dbReference type="FunCoup" id="Q2H0D9">
        <property type="interactions" value="604"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H0D9"/>
    <dbReference type="GeneID" id="4392082"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04757"/>
    <dbReference type="eggNOG" id="KOG2977">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_9_1_1"/>
    <dbReference type="InParanoid" id="Q2H0D9"/>
    <dbReference type="OMA" id="PQPLPCW"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="15">
        <location>
            <begin position="206"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="149"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAQ88138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="421" mass="46420" checksum="8089C75E891C0C91" modified="2006-03-21" version="1">MAADGVVESLEQLVWLLWATASERPFYFLLAVVLPLFGLGIFCVYILLHLVAPKPRLSYPSEKTYITTNPDGTASSPRPLACWYDRWHAEGKLSEEYSTIPAGFPVPDQGAIEPAEVEMSVVVPAYNEEARITAALEEMVEYLDQQFGRPNNQFLQPERQERSAEKGGKKGKRATTPHRLVFKPDTSTSTSPPGTARGPSEPPQPSGYEILIVDDGSRDRTVEVALSFARKHGLHDILRVVKLAKNRGKGGAVTHGLRHVRGKYAVFADADGASRFSDLGKLIEGCEDRSAIRNFLMRSFHFVLTILTPPATSRIRDTQCGFKLFSRAALPHIVPYMHAEGWIFDIEMLMLAESAPATPVLASDGSVIGTSYGIKVAEVPVGWHEVDGSKMSLVQDSVRMAIGLAVLRASWMLGVYRRRLT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-20" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0I3</accession>
    <name>KU70_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent DNA helicase II subunit 1</fullName>
            <ecNumber>3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>ATP-dependent DNA helicase II subunit Ku70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">KU70</name>
        <name type="ORF">CHGG_04713</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of Ku70 and Ku80.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ku70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223927.1">
        <property type="nucleotide sequence ID" value="XM_001223926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0I3"/>
    <dbReference type="SMR" id="Q2H0I3"/>
    <dbReference type="FunCoup" id="Q2H0I3">
        <property type="interactions" value="601"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H0I3"/>
    <dbReference type="GeneID" id="4392952"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04713"/>
    <dbReference type="eggNOG" id="KOG2327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014815_3_0_1"/>
    <dbReference type="InParanoid" id="Q2H0I3"/>
    <dbReference type="OMA" id="FWANVKH"/>
    <dbReference type="OrthoDB" id="3249161at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099115">
        <property type="term" value="C:chromosome, subtelomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120290">
        <property type="term" value="P:stalled replication fork localization to nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00788">
        <property type="entry name" value="KU70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01458">
        <property type="entry name" value="vWA_ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1600.10:FF:000004">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000071">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006165">
        <property type="entry name" value="Ku70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047087">
        <property type="entry name" value="KU70_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005160">
        <property type="entry name" value="Ku_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03730">
        <property type="entry name" value="Ku_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003033">
        <property type="entry name" value="Ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0779">Telomere</keyword>
    <feature type="chain" id="PRO_0000278340" description="ATP-dependent DNA helicase II subunit 1">
        <location>
            <begin position="1"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Ku">
        <location>
            <begin position="276"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="584"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="537"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="622" mass="68878" checksum="853F383DE2ED3482" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0J9</accession>
    <name>Q2H0J9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_04697</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223911.1">
        <property type="nucleotide sequence ID" value="XM_001223910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0J9"/>
    <dbReference type="STRING" id="306901.Q2H0J9"/>
    <dbReference type="GeneID" id="4392205"/>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="term" value="F:transcription cis-regulatory region binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ88078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="717" mass="80599" checksum="BFA69B4585C83F21" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0K4</accession>
    <name>Q2H0K4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_04692</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EAQ88073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001223905.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="4391635"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04692"/>
    <dbReference type="eggNOG" id="KOG0277">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_046581_1_0_1"/>
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    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cargo receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0005053">
        <property type="term" value="F:peroxisome matrix targeting signal-2 binding"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PEX7"/>
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        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
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        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
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        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="103"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="263"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ88073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="364" mass="39521" checksum="5CFA06EC7B69EDAC" modified="2006-03-21" version="1">MASMLEFRTPGFNPYAVKYSPYYDSRLAVSASANYGIVGNGRLFVLGLGPAGIQLEKGFDTNDALYDLAWSEINENQLVVACGDGSLKLFDLTAPGDFPVMNFNEHNREAFSVCWNPIAKDSFISSSWDGTIKIWSPSRPTSLKTLPVGNCTYSAAFSPTNPSIISCVSSDSHIRIFDLRSPVSAKYHLTTVIPAHAPPQTSDPTAPLPLLSTGQTFAGAVPAEILTHDWNKYRDTVIATGGVDRLIRTFDLRNPRAGPASVLPGHEYAVRRLAWSPHASDVLASASYDMTVRVWSDGSPAHQQQPQPQPNTIPVGTQLGVMNRHAEFATGVDWCLFGTGGWLASAGWDQRVLVWDAHTLLRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H113</accession>
    <name>Q2H113_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_04533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223747.1">
        <property type="nucleotide sequence ID" value="XM_001223746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H113"/>
    <dbReference type="STRING" id="306901.Q2H113"/>
    <dbReference type="GeneID" id="4392471"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04533"/>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_125_8_1"/>
    <dbReference type="InParanoid" id="Q2H113"/>
    <dbReference type="OMA" id="GREEHIN"/>
    <dbReference type="OrthoDB" id="427518at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ87914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="766" mass="84258" checksum="12EBCB0866856608" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1J6</accession>
    <name>Q2H1J6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_04350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223564.1">
        <property type="nucleotide sequence ID" value="XM_001223563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1J6"/>
    <dbReference type="GeneID" id="4392179"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04350"/>
    <dbReference type="HOGENOM" id="CLU_1294247_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H1J6"/>
    <dbReference type="OrthoDB" id="5215637at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="27"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="33"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ87731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="22019" checksum="E2AA57D112EE93CF" modified="2006-03-21" version="1">MCQATGEELVQAGASEFVRGTPSAITTIGVAPSSTSSSSTSTAVESSSITSDPSSSTTSEPDSTSQDSSTSTTPGQSDSGSEFETPAPNDDTSSGSTNIGAIVGGAVGGAVVVILAGLGGWLLARKRWANSGNGANGTQGNGNGNATSYGDHNDHDYARSYGNATSRIKHIIMYRHRQEGGVRRRRAVLTSWDCRRPGSAPVDTRWKCPWTFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1U6</accession>
    <name>Q2H1U6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_04250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223464.1">
        <property type="nucleotide sequence ID" value="XM_001223463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1U6"/>
    <dbReference type="FunCoup" id="Q2H1U6">
        <property type="interactions" value="841"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H1U6"/>
    <dbReference type="GeneID" id="4391778"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04250"/>
    <dbReference type="eggNOG" id="KOG2515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018152_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H1U6"/>
    <dbReference type="OMA" id="PRDMHAK"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF2">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE ALG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ87631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="613" mass="69430" checksum="0E9669C5FD97E1DE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H282</accession>
    <name>Q2H282_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223328.1">
        <property type="nucleotide sequence ID" value="XM_001223327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H282"/>
    <dbReference type="GeneID" id="4391879"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04114"/>
    <dbReference type="eggNOG" id="ENOG502RWWV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022148_3_0_1"/>
    <dbReference type="InParanoid" id="Q2H282"/>
    <dbReference type="OMA" id="STYSMLY"/>
    <dbReference type="OrthoDB" id="2796951at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012587728" description="Beta-glucuronidase C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="2">
        <location>
            <begin position="420"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="527" mass="57223" checksum="C8709E315F17162B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H285</accession>
    <name>Q2H285_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223325.1">
        <property type="nucleotide sequence ID" value="XM_001223324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H285"/>
    <dbReference type="GeneID" id="4391867"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04111"/>
    <dbReference type="eggNOG" id="ENOG502TD9U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1825073_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H285"/>
    <dbReference type="OMA" id="RAMSHTG"/>
    <dbReference type="OrthoDB" id="4590038at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="141" mass="15633" checksum="16FB2217772AF50D" modified="2006-03-21" version="1">MSNPTETIKQPAPGDAIADLAASLLSSPKHHHHHHHHPHPTATTTNNNPTATNQDTTAEDSGTERAMSHTGAWKPALDRRQSWSAQEYKHDLLKRQCMGGGAGKEGGGFSEVYVTFTGWSMDMKEHYGFQVKDREERAYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2J6</accession>
    <name>Q2H2J6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223214.1">
        <property type="nucleotide sequence ID" value="XM_001223213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2J6"/>
    <dbReference type="STRING" id="306901.Q2H2J6"/>
    <dbReference type="GeneID" id="4391937"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04000"/>
    <dbReference type="eggNOG" id="ENOG502RYS9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021768_0_2_1"/>
    <dbReference type="InParanoid" id="Q2H2J6"/>
    <dbReference type="OMA" id="YELPDDC"/>
    <dbReference type="OrthoDB" id="4582299at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="22660" checksum="21E6B8440AB41CD5" modified="2006-03-21" version="1">MDFHESSFFRPASNTSPTPQLPIPELVRETSKAQGLSVVMFENLNLVVKFGGPPNVKLEEAQVMWAIGKLFPTKDVPVPELFGWRDKTSIWGQLNQMVASIRRIQQPSFQPLIGSINYGQVQDIYFRGGEEARPFHAVSAFNDWVQFTALPWLPVSERPADPYRPLLPDTCKVHFTHADLHLYNIIISDTPGCRSIVGIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2M0</accession>
    <name>Q2H2M0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_03976</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
            <location evidence="1 6">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TUBGCP family.</text>
    </comment>
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        <property type="protein sequence ID" value="EAQ87357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001223189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2M0"/>
    <dbReference type="STRING" id="306901.Q2H2M0"/>
    <dbReference type="GeneID" id="4392071"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03976"/>
    <dbReference type="eggNOG" id="KOG2065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005595_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2M0"/>
    <dbReference type="OMA" id="NIAHRTY"/>
    <dbReference type="OrthoDB" id="78652at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF27">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="8">
        <location>
            <begin position="336"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="588"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ87357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="762" mass="82937" checksum="DDCAC7EB4881DDEB" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2P2</accession>
    <name>Q2H2P2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223168.1">
        <property type="nucleotide sequence ID" value="XM_001223167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2P2"/>
    <dbReference type="STRING" id="306901.Q2H2P2"/>
    <dbReference type="GeneID" id="4392509"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03954"/>
    <dbReference type="eggNOG" id="ENOG502QTVK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033074_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H2P2"/>
    <dbReference type="OMA" id="EPLAHIC"/>
    <dbReference type="OrthoDB" id="5317787at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="486" mass="54003" checksum="6589DEFB3C2CF323" modified="2006-03-21" version="1">MAASYPRRQPSSQSSSSHDSRSRRSNDSYTSHSTAPTSLYSSPCPSDLKDSPSSTDTGAYAGTKYRQNVYDSRDDVSPATSLYPRSSVETYASTTASSEDVEAMFADEVADYECGAIPPLPIYRREVVEPNVRASTPQDFAKLFPSLNRLTIRHDEFTSDGNMNLRIDTVVTGRRRTAIQLFHLRMYDLGKREFSLRRYSRDSGREVCNSKRKFTEPAAARPKTADGKPTLKRTMSTALKTLGGGKPVLRRAKSAMTSPSRPSTGYSTSEGDEDLFHDGSNQSRLSLDSRLGKGKAQRPVPTNTIKLEFSNYARVDVNRRGGKGNKRYEFEWWGHRYSWKRSVDKQLGLVSFHLVRDGNAGAPVAHIVPETRSPTQVVADDSAGGWVPPCFMWIADEAIVDAVTDVADVIMATGLMTLVDDCIKERWQTKKAHRIPMPSTFKSVNFDAVRPKAIMQHVFGRRNSNDHQRPSPPSSPLRHANPAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2U6</accession>
    <name>Q2H2U6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223114.1">
        <property type="nucleotide sequence ID" value="XM_001223113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2U6"/>
    <dbReference type="STRING" id="306901.Q2H2U6"/>
    <dbReference type="GeneID" id="4391540"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03900"/>
    <dbReference type="eggNOG" id="ENOG502RZBP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078841_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H2U6"/>
    <dbReference type="OMA" id="DPKECAK"/>
    <dbReference type="OrthoDB" id="5409186at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208848" evidence="2">
        <location>
            <begin position="21"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="253" mass="26492" checksum="7C01984B7889C4C8" modified="2006-03-21" version="1">MLVKSVAAFAALAFAANVAAEPMPYRPTMMKTSTRALFGIARREEQPGYQPEEAMCNDGNTCEEACGAGYQTCSSTDSQVHCFNPTVGELCCPDQSGSYYCTADTKGETWCCPGGHGSGRLRPPAYSVTGGLVSQTPPPATSTSTTSTSTSTSTTKAPITTTTTTSSSSTVVRNTTSVAVDSPTSAVLLPSSSSIQSNSTSVSTVKPAQPTESKGRGGRRQHRRPRDRPRPAGGRFCRPSLKLITAPSSAPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2W0</accession>
    <name>Q2H2W0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_03886</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223100.1">
        <property type="nucleotide sequence ID" value="XM_001223099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2W0"/>
    <dbReference type="FunCoup" id="Q2H2W0">
        <property type="interactions" value="362"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H2W0"/>
    <dbReference type="GeneID" id="4391612"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03886"/>
    <dbReference type="eggNOG" id="KOG0817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118853_2_0_1"/>
    <dbReference type="InParanoid" id="Q2H2W0"/>
    <dbReference type="OMA" id="WEAMITE"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="4"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ87267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="99" mass="10853" checksum="113C52741A966924" modified="2006-03-21" version="1">MVTQSEAFKKAAEESKQLTSKPSNEDLLEIYALYKIGTGEDVEKAPAPGGKAKLKAWQKAVDDGITVEQAQEKYVAKVEEMKTTYGFDANKQPEAVGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3B1</accession>
    <name>Q2H3B1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATPase AAA-type core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222949.1">
        <property type="nucleotide sequence ID" value="XM_001222948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3B1"/>
    <dbReference type="STRING" id="306901.Q2H3B1"/>
    <dbReference type="GeneID" id="4392188"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03735"/>
    <dbReference type="eggNOG" id="KOG0730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025506_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H3B1"/>
    <dbReference type="OMA" id="EVWVFDQ"/>
    <dbReference type="OrthoDB" id="2115716at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF132">
        <property type="entry name" value="ATP-DEPENDENT ZN PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="2">
        <location>
            <begin position="234"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="496" mass="55090" checksum="2C366B0BED7E72E5" modified="2006-03-21" version="1">MDTNTKQTLPVGVNTTSNEISQQFFRHSSAKRVNTDATIAKALKAEYPGLELVIAPSYGIDLLGYASAGHASFTSIDEASDELPSSLIWKVYVTPGRRIDGSPGSLAQDVIFAKFLYKWEDAEFILYLVDGRDGTSSYPPIRNNYILTTDTHKADALLIAAGQWGNELHEQVWVWDSGMWNKSAELYQSISKASWDAVILEDSMKKAIIADHQSFFDARDTYGRLKVPWKRGLIYYGPPGNGKTISIKATMHMLYDRKDPVPALYVRSFSSFAGPEYGISQIFLKARQYAPCYLIFEDLDSLVTDSVRSYFLNEIDGLRSNDGIFIVGSTNHLERLDPGIAKRPSRFDRKYYFPDPDRAQRVAYCRFWQRKLAGNKDIEFPDRLCGAIAGITDGFSFAYIQEAFVAALIVVARRGGGGGGDGDGGEEGEGEVAGWEAVEGEEIEGGWVGVADGEDDDDDDDDDDDDDGDGDLEDLVLWVEIKKQVAILREGMEEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3M4</accession>
    <name>Q2H3M4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_06741</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222836.1">
        <property type="nucleotide sequence ID" value="XM_001222835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3M4"/>
    <dbReference type="STRING" id="306901.Q2H3M4"/>
    <dbReference type="GeneID" id="4390764"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06741"/>
    <dbReference type="eggNOG" id="ENOG502QTAT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008220_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3M4"/>
    <dbReference type="OMA" id="ADHSIGW"/>
    <dbReference type="OrthoDB" id="38531at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057688">
        <property type="entry name" value="DUF7928"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25550">
        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="693"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="732"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="774"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="827"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="857"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7928" evidence="4">
        <location>
            <begin position="81"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="503"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ90122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="886" mass="99536" checksum="E2248C6E779AC09A" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4D9</accession>
    <name>Q2H4D9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_06476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222571.1">
        <property type="nucleotide sequence ID" value="XM_001222570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4D9"/>
    <dbReference type="STRING" id="306901.Q2H4D9"/>
    <dbReference type="GeneID" id="4391424"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06476"/>
    <dbReference type="HOGENOM" id="CLU_1337363_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4D9"/>
    <dbReference type="OrthoDB" id="5105430at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22515" checksum="40DE44164D88A822" modified="2006-03-21" version="1">MATATGDGAIARRSTRRSINAFSSTSSQSERKTSILKAIAAYHDTKDRTHLLQALSFIDCALGKSSNQEGRNVVDLLFTKPHEIDKEAASEVAEILRIPNLVYHPMSFAERSTWKERAKVILFLSATAGGTGLNIATASRLIICEPQFSPGSDSRLYRLPQIQDLSVYRVVGQSCAVDAYLVGNSVRKSEFERGPMTSRVPKVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4K9</accession>
    <name>Q2H4K9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_06406</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PET191 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222501.1">
        <property type="nucleotide sequence ID" value="XM_001222500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4K9"/>
    <dbReference type="FunCoup" id="Q2H4K9">
        <property type="interactions" value="222"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H4K9"/>
    <dbReference type="GeneID" id="4390248"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06406"/>
    <dbReference type="eggNOG" id="KOG4114">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138069_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4K9"/>
    <dbReference type="OMA" id="GNMPVTY"/>
    <dbReference type="OrthoDB" id="282149at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018793">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_Pet191"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10203">
        <property type="entry name" value="Pet191_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ89787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15210" checksum="BF79502315238DB5" modified="2006-03-21" version="1">MPSSCKDIRAALAECLQESECVMVQRHSAAECMREPLLSTLPTKCQQLKKGFGECRRGMVDMRKRFRGNQPVAFRKLEQNEKTGEGYQLYAGKSAFAGTRGETDGNEKEPQDWREAENEKYRAAAAAAAAANKSSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4Q2</accession>
    <name>Q2H4Q2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exosome complex exonuclease Rrp40 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222458.1">
        <property type="nucleotide sequence ID" value="XM_001222457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4Q2"/>
    <dbReference type="STRING" id="306901.Q2H4Q2"/>
    <dbReference type="GeneID" id="4391269"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06363"/>
    <dbReference type="HOGENOM" id="CLU_2621810_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H4Q2"/>
    <dbReference type="OrthoDB" id="340500at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000073">
        <property type="entry name" value="Putative Exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041054">
        <property type="entry name" value="Rrp40_N_euk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18311">
        <property type="entry name" value="Rrp40_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exosome complex exonuclease Rrp40 N-terminal" evidence="1">
        <location>
            <begin position="27"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="78" mass="8588" checksum="76B202F9749D8759" modified="2006-03-21" version="1">MATGYPIVLPGETIDPSLIPSHPKNPLRLGPGLRHIPPTDIVPTVAGQLITNPAKNSMWIEYNSNRVGVDIFFEERAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H505</accession>
    <name>Q2H505_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tip elongation aberrant protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_06260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
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                <person name="Untereiner W.A."/>
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        <source>
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    <dbReference type="HOGENOM" id="CLU_053011_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6H9"/>
    <dbReference type="OMA" id="RPRFMAQ"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ89117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="36477" checksum="DC7BC1E050E27032" modified="2006-03-21" version="1">MSSTSVLTPEEKEHFLTHGWVKISNAFTQEQADKVNANVWTRLGMDPNDQSTWTRLRTNMPGHNKFDPADFAPRAWAAICELCGGEDRVDPASREWRDSLIVNLGDEKHGGKPVPPQELPEWHVDGDFFVHYLDSREQALLVTPLFTDIVSNGGATMICPEAIPKIAKHLYEHPEGVSPRMVPRGEEGFQVGQHKDLSFFCNVAKSCDNFVEATGKVGDVYLMHPLMLHAPSSNALRKVRIIINPAVSLKEEHCFDRADGNYSLVEQFTLRALGKERLSGWKATGPRETVVPARLQVQEKMRQEELKRLAELKAKEEQKTVSATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6I6</accession>
    <name>Q2H6I6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_05729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221824.1">
        <property type="nucleotide sequence ID" value="XM_001221823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6I6"/>
    <dbReference type="STRING" id="306901.Q2H6I6"/>
    <dbReference type="GeneID" id="4390100"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05729"/>
    <dbReference type="eggNOG" id="ENOG502S1MK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051552_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H6I6"/>
    <dbReference type="OMA" id="DMGEDLH"/>
    <dbReference type="OrthoDB" id="21266at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070692">
        <property type="term" value="C:CTDK-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032786">
        <property type="term" value="P:positive regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042326">
        <property type="entry name" value="Ctk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024637">
        <property type="entry name" value="Ctk3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024638">
        <property type="entry name" value="Ctk3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291:SF1">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12243">
        <property type="entry name" value="CTK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12350">
        <property type="entry name" value="CTK3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="3"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ89110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="202" mass="23179" checksum="FAD4191C0E919F20" modified="2006-03-21" version="1">MADPFEVRMRFTNQLRQLNASVTSAQKAAQYALKYRDMAEDLHSCILEQLERVLHALQSKNFLEAQAVTQIEEVLKERDASAQDIAMSSPPLNGDGIPDNLGDMPPSRTLPPYNKKGNGPPKLDKKQTEQRIEEDRERHKRQRENIWAVPPGEDAEMEKLWEETSDLGEDDHRMGEEEWAEWEAEFEARKCSHRKEGANGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6L6</accession>
    <name>Q2H6L6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translationally-controlled tumor protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_05699</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCTP family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221794.1">
        <property type="nucleotide sequence ID" value="XM_001221793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6L6"/>
    <dbReference type="FunCoup" id="Q2H6L6">
        <property type="interactions" value="783"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H6L6"/>
    <dbReference type="GeneID" id="4391002"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05699"/>
    <dbReference type="eggNOG" id="KOG1727">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095877_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6L6"/>
    <dbReference type="OMA" id="AYNKCIK"/>
    <dbReference type="OrthoDB" id="10248936at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.10:FF:000002">
        <property type="entry name" value="Translationally-controlled tumor protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01003">
        <property type="entry name" value="TCTP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ89080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="169" mass="19034" checksum="1418E60C9F50347D" modified="2006-03-21" version="1">MLIYKDVISGDEIISDSYDLKEVDGIVYEADCAMIIEGAVQVDTGANASAEEAEEGVEDQDVRVNNIVSSFRLQSTSFDKKSYLTYLKGYMKAVKKHLQDSGKSQDEITEFETKAQVFAKKVIGSFKDWEFYTGESMNIDGMVVLLNYREDGVTPYVVVWKHGLKEEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6Z0</accession>
    <name>Q2H6Z0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycoside hydrolase family 5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_05575</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221670.1">
        <property type="nucleotide sequence ID" value="XM_001221669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6Z0"/>
    <dbReference type="STRING" id="306901.Q2H6Z0"/>
    <dbReference type="GeneID" id="4390787"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05575"/>
    <dbReference type="eggNOG" id="ENOG502QVYM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039562_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H6Z0"/>
    <dbReference type="OMA" id="CCNLDDG"/>
    <dbReference type="OrthoDB" id="442731at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263:SF0">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208578" description="Glycoside hydrolase family 5 domain-containing protein" evidence="5">
        <location>
            <begin position="23"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="68"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ88956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="424" mass="47086" checksum="36528575C357062F" modified="2006-03-21" version="1">MARLLPFHLLLLTLLLPLLTTAATLPALPLHSTSRWIVDSNHTRVKLRCVNWAGHMETHLPEGLQHQPLSYLLDWIAAQDFNCVRLTYSTDAALDPHRTVAAAFEKAAAAAGVGQAEMAALYARVVEKNPWIGANTTTREVVAAVVDGLFARGVLTILDNHVSRAAWCCNLTDGNGWWDEGFGYNTWNSRFFNTQQWLAGLEAMAAWGKGHAGVVGYGLRNEIREFLLQGLNGRADWYTYVKKGGDVVHAAHPDALVLVGGVQSTTDLLHLRSGEAEAMLDTSGWAGKHVWEMHAYSFTVTFPDAFNNCDIVKAQYGAFVGFVLEQGKPYTGPLILSEFGVGMEGGEFDGLSEKDNRYLNCLVSYMQSNDADWAVWAIQGSYYVRDGKTDYDETWGLMDRNWTDWRNPAFSGKLGDMWKMTQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7H1</accession>
    <name>Q2H7H1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_05394</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221489.1">
        <property type="nucleotide sequence ID" value="XM_001221488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7H1"/>
    <dbReference type="FunCoup" id="Q2H7H1">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="GeneID" id="4389979"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05394"/>
    <dbReference type="eggNOG" id="ENOG502S2VF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_2_1_1"/>
    <dbReference type="InParanoid" id="Q2H7H1"/>
    <dbReference type="OMA" id="CIVQTRY"/>
    <dbReference type="OrthoDB" id="5273647at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF146">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="37"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ88775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="354" mass="38750" checksum="9F9F2C23C728E28A" modified="2006-03-21" version="1">MVWVDNATAEIDAISEWRTIVAICTVLSAFSIAIVMARVWIRHKNHGLAADDWMAMLSMAFALIYSLLCIVQTKYGLGLPLKLRPKENLIPYTRSNYAGRPIYQIGISFFKVALLISYLRLFKGTNHIIYRRVVWVAIVAVVAGHLGCALTLILACSPVHKSWDPLTPGTCLAPGPSFTAYAIVTIVSDVVVAVIPIPVLLQLKVNLGKKIGLIVIFLLGLFTTLCSVFRYLQIDRIQYGDGNSTMLILWGVIEFNVGNVVSSLPFLAPIFLRKAKQYTTKYSGSGNNYGSGARKIGKSSEAYKLSSISSQVKGTFATAQGQSNGSEENILKSSTENAPENTIMKSVTYSVRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7L8</accession>
    <name>Q2H7L8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidoligase enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221442.1">
        <property type="nucleotide sequence ID" value="XM_001221441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7L8"/>
    <dbReference type="GeneID" id="4390565"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05347"/>
    <dbReference type="eggNOG" id="ENOG502SUNA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_660562_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7L8"/>
    <dbReference type="OMA" id="INYFESS"/>
    <dbReference type="OrthoDB" id="5291055at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022025">
        <property type="entry name" value="Amidoligase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847:SF1">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12224">
        <property type="entry name" value="Amidoligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="46767" checksum="B614EDE219C0C821" modified="2006-03-21" version="1">MSARGQKQGTQPSAQRTSPNRGGKAPVANPRGVPPPPPPPPPPQQPPVNPPQRPAVQQRPKTPPENSIGIGIETEFYLASRQNETHQSLRLFAKAMVEKYHAEIGPSSRLPKMHSLVGDLYRGPHGMRHTEWALHHDPTCETTNSPWGIELVSPILTAYKGGEVWRESVSQMWRFLSLRYGVTADASCSTHVHLSLARGFSLTQLKRLAQAVIYFECAVEALMPPDRRGNEYARSNWIDNKHLAYKNLNRDQSMLAIEACKSQEEVIALMNPDKSKYFGVNFLALERYKTVEFRRGAASTKLNDVFMWVEFAMTFLQASIQLPSKNDFSRFQPTVGGLRNFFDNAHLVEDPGMNQRKYLDLLFHGHASNQRAEPIPVKLETLSKEKKAKLSKKIEADKQSNPMLDKIGDATREGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7Q8</accession>
    <name>Q2H7Q8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221402.1">
        <property type="nucleotide sequence ID" value="XM_001221401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7Q8"/>
    <dbReference type="GeneID" id="4391491"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05307"/>
    <dbReference type="HOGENOM" id="CLU_1180093_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7Q8"/>
    <dbReference type="OrthoDB" id="4177740at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="235" mass="26370" checksum="9AAD08BCC2692355" modified="2006-03-21" version="1">MSDQTADIPLRPSDLSALRRHKVMALPAPSSGRPDESESFLPIYCIAINLVARWETWAQPEQGKMCTNPIENREPEEISKQERPKLLFSSFEFTYNLVPGAGRTVMPEAWEPLRGGYGYTPVYTYFPSHPFVLKDEAKGLPHIASGVTDSEDPRSDSVLRARITQIHYDGQHLGIRQSRLLSFKGPEPTPDAYLMIRWMTAMPIGDTEYKSPRGSEDVAEANEATGRAEDVNFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7V2</accession>
    <name>Q2H7V2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221358.1">
        <property type="nucleotide sequence ID" value="XM_001221357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7V2"/>
    <dbReference type="GeneID" id="4391347"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05263"/>
    <dbReference type="eggNOG" id="ENOG502S5MR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_355635_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7V2"/>
    <dbReference type="OMA" id="KIGENWN"/>
    <dbReference type="OrthoDB" id="4286061at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="789" mass="83630" checksum="B7A006ED03D05B51" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7W2</accession>
    <name>Q2H7W2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_03692</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230208.1">
        <property type="nucleotide sequence ID" value="XM_001230207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7W2"/>
    <dbReference type="STRING" id="306901.Q2H7W2"/>
    <dbReference type="GeneID" id="4389904"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03692"/>
    <dbReference type="eggNOG" id="ENOG502SPU4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031730_1_3_1"/>
    <dbReference type="InParanoid" id="Q2H7W2"/>
    <dbReference type="OMA" id="CANIRIT"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF6">
        <property type="entry name" value="ENDOGLUCANASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208607" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="20"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="20"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ91757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="250" mass="26745" checksum="AE4108686A4258F5" modified="2006-03-21" version="1">MLFQAALGVILAGPSPVTAHGYVDKWTIDGQSYTGFNPTTAPWVPDQGTISWPAWNTDTGPVYGSNVDSPDIICSVNATNSKIYPVPVAAGSTIKLHWTTWPESHHGPMFTYLAACNGDCVTADKKQLRWFKIAELGQISYGAGGGKSGVWAADQLRLAGGDWDVTIPSSIKAGNYVLRHEILALHSAYDVGGAQFYPQCTNIQITGGGNDTPAGVVGTSLYTKDEPGVHYNIYNDESKPIYQMPGPPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7Z0</accession>
    <name>Q2H7Z0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_03664</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230180.1">
        <property type="nucleotide sequence ID" value="XM_001230179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7Z0"/>
    <dbReference type="STRING" id="306901.Q2H7Z0"/>
    <dbReference type="GeneID" id="4388435"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03664"/>
    <dbReference type="eggNOG" id="KOG2733">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_383138_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7Z0"/>
    <dbReference type="OMA" id="HEVRCAN"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43781">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43781:SF1">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="345"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="379"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="419"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ91729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="783" mass="85318" checksum="968BB495697E1785" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H850</accession>
    <name>Q2H850_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230120.1">
        <property type="nucleotide sequence ID" value="XM_001230119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H850"/>
    <dbReference type="GeneID" id="4389654"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03604"/>
    <dbReference type="eggNOG" id="ENOG502SKGQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027514_2_2_1"/>
    <dbReference type="InParanoid" id="Q2H850"/>
    <dbReference type="OMA" id="NARHIWA"/>
    <dbReference type="OrthoDB" id="3251507at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="490" mass="55827" checksum="8CB27815D0DE72F4" modified="2006-03-21" version="1">MAVLDFPGKREELNKNQQSTLRHEFYPPLFLLDSLNQVCPRGSRRTPSDGPQNEHQSPEERFQTLVNKLAQICDFEPKGNTVSALAVIIHNGRLCYVLASNRRGTGAMKNARAGLQAVLNILKDSVEKRTDDSDEVMEKRLMREILTWNMVRARSYLTSLEKELQKCIAKCDTTEQGNNAKQELQRLAAFLPKVKDGQKSDSYIESTMRLIAAIQTSRESQLPTWRYIEAGAVADDTMAKGGCWSALQHSAGRLLSYRYAAHSLVNARHIWAETDLFRDFDIETVRSSLPNAKAGTLSPETVEDILNRAPNATKAQRKAYRQHAAELQVYDLNAKLAEQWDRKLEPIVHAEMLLHEWLSRTEGGTQSYRFFNGWQYIGTSKPVCKLCTDYFDIISTPVRFRPGHPNTYLNWRLPDIYVEGKDPVAVDRAKAEWNSNLDEMKKRIYVALLRVLQDKVSGKKPNDSNTYSERITTGDADYISKWLGKIQINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8I7</accession>
    <name>Q2H8I7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229983.1">
        <property type="nucleotide sequence ID" value="XM_001229982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8I7"/>
    <dbReference type="GeneID" id="4389458"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03467"/>
    <dbReference type="HOGENOM" id="CLU_1156261_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8I7"/>
    <dbReference type="OrthoDB" id="10403007at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="240" mass="25701" checksum="A18361F9A5AF02F6" modified="2006-03-21" version="1">MMTASDQITLITETDSPSTLVGSQANAPGFSPLLHWLLAPRKDGAWIPLDPSLQAPAANDAEASLARANFPGINPSWDYRTGIARSQPPRRTLRLAGISRPSSTATLRSRRTPRPQSSCRPKQELHDDFLPQIKIRESDLTSEVPPELIPDGTINPALLMPAVNINQPPQTTDASHPMATGDSALNRPGPISPPGHRGNGLDPSPAPLTPSDGPETEDDAVEAMIHEFLNLDEDETRAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8W3</accession>
    <name>Q2H8W3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Heat shock protein HSP98</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_03341</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229857.1">
        <property type="nucleotide sequence ID" value="XM_001229856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8W3"/>
    <dbReference type="FunCoup" id="Q2H8W3">
        <property type="interactions" value="444"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H8W3"/>
    <dbReference type="GeneID" id="4389496"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03341"/>
    <dbReference type="eggNOG" id="KOG1051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_2_1"/>
    <dbReference type="InParanoid" id="Q2H8W3"/>
    <dbReference type="OMA" id="ERMKAVM"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140453">
        <property type="term" value="C:protein aggregate center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="entry name" value="Clp, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF18">
        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="Double Clp-N motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="9">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="431"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ91406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="925" mass="102994" checksum="0665C9A1DD0515E4" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H9T2</accession>
    <name>Q2H9T2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
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        <property type="entry name" value="Polarity_Bud-Selection_Reg"/>
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        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1"/>
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</entry>
<entry dataset="Swiss-Prot" created="2007-02-20" modified="2025-06-18" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HA14</accession>
    <name>ALG8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.265</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Asparagine-linked glycosylation protein 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ALG8</name>
        <name type="ORF">CHGG_02940</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the second glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(1)Man(9)GlcNAc(2)-PP-Dol to produce Glc(2)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19521"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132521"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="EC" id="2.4.1.265"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:31308"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
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        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
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        <property type="term" value="F:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
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        <property type="term" value="P:protein N-linked glycosylation"/>
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        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
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        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF2">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE-RELATED"/>
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        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
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    <evidence type="ECO:0000250" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="474" mass="53203" checksum="0CDFCB6490673714" modified="2006-03-21" version="1">MSEIYPSLAQCAIVAGALKILLFPAYKSTDFEVHRNWLAITNSFPLWDWYYEKTSEWTLDYPPFFAYFEWVMSQVAKLVDPAMLKVYNLEFIDSSHGASKRAAQAAAISILLSPGLFIIDHIHFQYNGAMYGILIASLVLARKKSTLLWSGLLFAALLCMKHIYLYLAPAYFVFLLRAYCLSPKSVFRIQFLNCVKLGAGIGAILGTAFGPFALKGQIPQIFNRLFPFSRGLCHAYWAPNVWAMYSFVDRVLIVLAPRLGLSVKEGALQSVTRGLVGDTAFAVLPDVTPRVCFALTLIFQAIPLLKLFAQPTWDNFIGAVTLCGYASFLFGWHVHEKAILLVIIPFSLIALKDRRYLGAFRPLAVAGHVSLFPLLFTPAEFPLKTVYTVFWLILFLMAFDRLAPASSRARFFLFDRFSTLYITISIPLIVYCSLGHGIVFGKSYEFLPLMFTSSYSAIGVVGSWVGFMVVYFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HB27</accession>
    <name>Q2HB27_CHAGB</name>
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        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_02577</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
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            <taxon>Eukaryota</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
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                <person name="Untereiner W.A."/>
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</entry>
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                <person name="Untereiner W.A."/>
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</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
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        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228984.1">
        <property type="nucleotide sequence ID" value="XM_001228983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBD6"/>
    <dbReference type="STRING" id="306901.Q2HBD6"/>
    <dbReference type="GeneID" id="4388781"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02468"/>
    <dbReference type="eggNOG" id="KOG4629">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010480_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HBD6"/>
    <dbReference type="OMA" id="FWWLGIE"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015275">
        <property type="term" value="F:stretch-activated, monoatomic cation-selective, calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000345">
        <property type="entry name" value="Mechanosensitive ion channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF15">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017209">
        <property type="entry name" value="Memb_At2g17000_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="483"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="427"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="717"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="765"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="773"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="792"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR017209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ90533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="835" mass="94562" checksum="57F7DFA255B59B72" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-09-29" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBN5</accession>
    <name>CGHB_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4-hydroxy-4-methyl-2-oxoglutarate aldolase cghB</fullName>
            <ecNumber evidence="2">4.1.3.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Sch210972 biosynthesis cluster protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cghB</name>
        <name type="ORF">CHGG_02369</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2015" name="ChemBioChem" volume="16" first="2294" last="2298">
            <title>Involvement of lipocalin-like CghA in decalin-forming stereoselective intramolecular [4+2] cycloaddition.</title>
            <authorList>
                <person name="Sato M."/>
                <person name="Yagishita F."/>
                <person name="Mino T."/>
                <person name="Uchiyama N."/>
                <person name="Patel A."/>
                <person name="Chooi Y.H."/>
                <person name="Goda Y."/>
                <person name="Xu W."/>
                <person name="Noguchi H."/>
                <person name="Yamamoto T."/>
                <person name="Hotta K."/>
                <person name="Houk K.N."/>
                <person name="Tang Y."/>
                <person name="Watanabe K."/>
            </authorList>
            <dbReference type="PubMed" id="26360642"/>
            <dbReference type="DOI" id="10.1002/cbic.201500386"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="2">4-hydroxy-4-methyl-2-oxoglutarate aldolase; part of the gene cluster that mediates the biosynthesis of the tetramic acid Sch210972, a potential anti-HIV fungal natural product that contains a decalin core (PubMed:26360642). The PKS module of cghG together with the enoylreductase cghC catalyze the formation of the polyketide unit which is then conjugated to 4-hydroxyl-4-methyl glutamate (HMG) by the condensation domain of the cghG NRPS module (PubMed:26360642). One unique structural feature of Sch210972 is the tetramic acid motif proposed to be derived from the non-proteinogenic amino acid HMG, by a Dieckmann-type condensation catalyzed by the reductase domain of cghG (PubMed:26360642). The aldolase cghB catalyzes the aldol condensation of 2 molecules of pyruvic acid to yield the intermediate 4-hydroxyl-4-methyl-2-oxoglutarate (HMOG), which can then be stereoselectively transaminated by an unidentified enzyme to form HMG (PubMed:26360642). The Diels-Alderase cghA then uses the Dieckmann product released by cghG as substrate and catalyzes the Diels-Alder cycloaddition to form the decalin ring of Sch210972 (PubMed:26360642). CghA also suppresses the nonenzymatic formation of the alternative stereoisomer (PubMed:26360642).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate</text>
            <dbReference type="Rhea" id="RHEA:22748"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:58276"/>
            <dbReference type="EC" id="4.1.3.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="2">
            <dbReference type="Rhea" id="RHEA:22750"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HpcH/HpaI aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.17" evidence="2"/>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228885.1">
        <property type="nucleotide sequence ID" value="XM_001228884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBN5"/>
    <dbReference type="SMR" id="Q2HBN5"/>
    <dbReference type="GeneID" id="4388354"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02369"/>
    <dbReference type="eggNOG" id="ENOG502SJZ2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059964_4_0_1"/>
    <dbReference type="InParanoid" id="Q2HBN5"/>
    <dbReference type="OMA" id="EHVLINP"/>
    <dbReference type="OrthoDB" id="2326446at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047443">
        <property type="term" value="F:4-hydroxy-4-methyl-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0170">Cobalt</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000453345" description="4-hydroxy-4-methyl-2-oxoglutarate aldolase cghB">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="site" description="Increases basicity of active site His" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q47098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="26360642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="26360642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ90434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="269" mass="28272" checksum="351D7DD8620265FB" modified="2006-03-21" version="1">MASFNNVLTKAAAGRLCKAMGVRMVANPLVVQLAANAGFEALFIDLEHSTLSLADASAIACAGLLSGLTPLVRVPYQCGIGFVQQALDGGAMGIVFPHIHTAADARAAVQTCKFPPLGVRSMWGQQPALGMRVTAIGRIVEVCNAAASSVIVMIEAASSIENIEAIAAVEGVDVLLVGCLDLSTDMGMPGRFETRAFRTALEKVSAACRHSGKTMGLAGIYNNRELHEWAINTLNVRFMLCQQDSNLLAMAAVDCASAVAKIDRARLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBP1</accession>
    <name>Q2HBP1_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00191</name>
        <name evidence="1" type="ORF">CHGG_02363</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2005-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Giovannoni S.J."/>
                <person name="Cho J.-C."/>
                <person name="Ferriera S."/>
                <person name="Johnson J."/>
                <person name="Kravitz S."/>
                <person name="Halpern A."/>
                <person name="Remington K."/>
                <person name="Beeson K."/>
                <person name="Tran B."/>
                <person name="Rogers Y.-H."/>
                <person name="Friedman R."/>
                <person name="Venter J.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 148.51</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2006-02" db="EMBL/GenBank/DDBJ databases">
            <title>Annotation of the Chaetomium globosum CBS 148.51 Genome.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Birren B."/>
                <person name="Lander E."/>
                <person name="Galagan J."/>
                <person name="Devon K."/>
                <person name="Nusbaum C."/>
                <person name="Ma L.-J."/>
                <person name="Jaffe D."/>
                <person name="Butler J."/>
                <person name="Alvarez P."/>
                <person name="Gnerre S."/>
                <person name="Grabherr M."/>
                <person name="Kleber M."/>
                <person name="Mauceli E."/>
                <person name="Brockman W."/>
                <person name="Rounsley S."/>
                <person name="Young S."/>
                <person name="LaButti K."/>
                <person name="Pushparaj V."/>
                <person name="DeCaprio D."/>
                <person name="Crawford M."/>
                <person name="Koehrsen M."/>
                <person name="Engels R."/>
                <person name="Montgomery P."/>
                <person name="Pearson M."/>
                <person name="Howarth C."/>
                <person name="Kodira C."/>
                <person name="Yandava C."/>
                <person name="Zeng Q."/>
                <person name="Alvarado L."/>
                <person name="Oleary S."/>
                <person name="Untereiner W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 148.51</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219412.1">
        <property type="nucleotide sequence ID" value="XM_001219411.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228879.1">
        <property type="nucleotide sequence ID" value="XM_001228878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBP1"/>
    <dbReference type="GeneID" id="4387598"/>
    <dbReference type="GeneID" id="4389526"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00191"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02363"/>
    <dbReference type="HOGENOM" id="CLU_2704591_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HBP1"/>
    <dbReference type="OrthoDB" id="4591102at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ90428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="73" mass="7694" checksum="7D8CC53103373FC7" modified="2006-03-21" version="1">MQRKALSARTGSVVRAQNLLQCVGGETGSASDCSRAADPMEIGAISSNTITPVPGREYLADADVEPIFGRKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDG5</accession>
    <name>Q2HDG5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_01739</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220960.1">
        <property type="nucleotide sequence ID" value="XM_001220959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDG5"/>
    <dbReference type="GeneID" id="4386771"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01739"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="Q2HDG5"/>
    <dbReference type="OMA" id="KDANTMF"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000245">
        <property type="entry name" value="Short chain dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="71"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ93504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="324" mass="34617" checksum="27B9D2FA0D27FC83" modified="2006-03-21" version="1">MPPFTSSRTALRAGSRALLARRCIQPQTASPLAIFSRSLHQTRTLQQQQGRNTTTKPTGSTLLPEFSLRDRVVIVSGGARGVGLTQAEALLEAGAVVHALDRLPTPTGDSDFARVAGRAAAELGTRMRYHRVDVRDQAALGDVVGAIAEEEGRVDGLIAAAGIQQETPALEYTAEDADRMLGVNVTGVFMTAQAVAREMIKRKQKGSLVLIGSMSGTVANRGLICPAYNASKAAVLQLARNLASEWGEHGIRVNTISPGYIVTAMTASLFDAVPERRTAWPDANMLKRLSYPEEYRGAAVFLLSDASSFMTGADLRIDGGHCAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDM5</accession>
    <name>Q2HDM5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220900.1">
        <property type="nucleotide sequence ID" value="XM_001220899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDM5"/>
    <dbReference type="STRING" id="306901.Q2HDM5"/>
    <dbReference type="GeneID" id="4387764"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01679"/>
    <dbReference type="eggNOG" id="ENOG502STJP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_594465_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HDM5"/>
    <dbReference type="OMA" id="ETEHEMW"/>
    <dbReference type="OrthoDB" id="3538943at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="460" mass="50103" checksum="71741C9C93AAEEE2" modified="2006-03-21" version="1">MYLQKADLAQAPQAKRPRRWKAPVYSSPGPVEEGHAPGLTVPKARTVVLPQPSSAIGSPSSPVLPPLPHPPAGRFSVVPSTGDQPIPTPANRQEVVAATPQPVATDQAFSNSTDKPPPNGPASQVPYTAFIVAYPDYRGSLGTFLRAAMCILPLQKDRALPEFLYDDFIRVFSTDFLKYIGSLDENTRPLSAIQFYNEHVSRPLYTKCVLTKDNINDVTEKYPEESRAIQQTLEKSEARRRPTRQLPGKMAADKHMVQLPPAPMDTSHPLPQNVLPSSASVINHDAVTRETSPHTASIHPTVPMLPLQEHRETDAPVTASRNVSGSSSVHRHRAQAEIPAILTATSPSGLEVLRTQVDSSPPRTRPSPPPKVTKINLPVASTLPGNMLSQISHPDSIPETVLKRKAAPRASVGSSAPEPGGEFKRQRTATKDVDKRALRFRKFLIQKRTQSSAPEQSTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDS8</accession>
    <name>Q2HDS8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cylicin I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220847.1">
        <property type="nucleotide sequence ID" value="XM_001220846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDS8"/>
    <dbReference type="STRING" id="306901.Q2HDS8"/>
    <dbReference type="GeneID" id="4387072"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01626"/>
    <dbReference type="eggNOG" id="KOG1181">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033575_2_1_1"/>
    <dbReference type="InParanoid" id="Q2HDS8"/>
    <dbReference type="OMA" id="DMATNDK"/>
    <dbReference type="OrthoDB" id="9932926at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="46353" checksum="3A9D8A5DB4CCCA80" modified="2006-03-21" version="1">MASEGSEAKSYSTDPALYIYTSLTAGSSHIVTATSRLETILRANRVPFKALDIATDEKARMLWGRRAGKDESGRQRKLPGLVQMGMILGDLVEIEEWNEYGELKQHVTMYYDEFTQPSISQAPKQAPPAAPKAPPAPAPKTTIERVAAVSKAAEKATLPVRTIAEEVAAKAKQVHLQSLRNKVHGKDSNPSSPTTTSPTVTTTSTSSVAATAGAGLQSPTTSGWKASSAPAPIQSPTTTGWKPQDVDPPVRELRGAAVTPASPDEIAAVERAETIREEPGRESSDDEDDEEEESDEDEDDEEEESEDEDEEESEEEEEKPAAKVAGKAAEVKKVEEVKKPVEVKKSGEAKKSREVKKAGETKKTSDVKKTRDAQKVGASKKPSEVKKTGESKKTKESKEAKKTKEVKKTKEVKKTGESKKTGESKKAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEQ6</accession>
    <name>Q2HEQ6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220519.1">
        <property type="nucleotide sequence ID" value="XM_001220518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEQ6"/>
    <dbReference type="GeneID" id="4388168"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01298"/>
    <dbReference type="eggNOG" id="ENOG502SH2P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066708_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HEQ6"/>
    <dbReference type="OMA" id="YSQTWFK"/>
    <dbReference type="OrthoDB" id="58416at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053206">
        <property type="entry name" value="Dimeric_xanthone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048:SF2">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="230" mass="26091" checksum="66A783AD33C7A8DA" modified="2006-03-21" version="1">MALLHNSIFRGYNSIYHQAPLVADKDKADFVGYCLTWFKFVKSHHDDEEATLFTKIEELLQDKTVFEETHKEHESFLPGLADFEKYLAGLKTPSDFSGDELLRIMQSFQQPFEQHFHSEIATISNFADHPNAPKHGTPENDAASATFKAWGKSTVTKAGVTDVVPFFLLNLDRTVENGMWANWPPMPAPIRWGLINLVGAWRSAWWKFASCDAAGQPQELWAYRATQAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HF74</accession>
    <name>Q2HF74_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_01130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the clathrin heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220351.1">
        <property type="nucleotide sequence ID" value="XM_001220350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q2HF74"/>
    <dbReference type="FunCoup" id="Q2HF74">
        <property type="interactions" value="1098"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HF74"/>
    <dbReference type="GeneID" id="4387605"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01130"/>
    <dbReference type="eggNOG" id="KOG0985">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002136_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HF74"/>
    <dbReference type="OMA" id="HCYDLLH"/>
    <dbReference type="OrthoDB" id="2113814at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000001">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000002">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000005">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000082">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.730:FF:000003">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.110:FF:000003">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022365">
        <property type="entry name" value="Clathrin_H-chain_propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016341">
        <property type="entry name" value="Clathrin_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13838">
        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01394">
        <property type="entry name" value="Clathrin_propel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002290">
        <property type="entry name" value="Clathrin_H_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50989">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="538"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="690"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="838"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="984"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1133"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1279"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1428"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1619"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1619"/>
            <end position="1637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ92895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1680" mass="189912" checksum="86675AA11949E7C5" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFE2</accession>
    <name>Q2HFE2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome recycling factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_01062</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220283.1">
        <property type="nucleotide sequence ID" value="XM_001220282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFE2"/>
    <dbReference type="FunCoup" id="Q2HFE2">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HFE2"/>
    <dbReference type="GeneID" id="4386498"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01062"/>
    <dbReference type="eggNOG" id="KOG4759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072873_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HFE2"/>
    <dbReference type="OMA" id="NVICGEE"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="5">
        <location>
            <begin position="127"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="64"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ92827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="299" mass="32989" checksum="09429A1E66F4F28E" modified="2006-03-21" version="1">MRRLRTANNILRSNAASGAPLSRRAASSLIPNRTPLLNQPTPTSYSIAVASNTLWSQPLARPFSHTAPCQKKKNSNKKNNNSNYSDDSDSTGQTTPSAGSAGADAEGPNPFDFADLQTAFDRAEKHFSEDLKKLRSGGRFNAEVIGAIPVQTDKKNPQTFPLRELATVAPLGGRRWSILAFEEGSVKAIVSAVQRSDEFNQQPQRSAENPLELTMTVEPERADALARRAKEVCQAWRVRVRDEAHRRAELHKKWRGEGVVLSDDAHKLKDKLQKLQDERMKAILAKEKEAVGAIMARAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFF3</accession>
    <name>Q2HFF3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_01051</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Alkaloid biosynthesis; ergot alkaloid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fgaFS/easG family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220272.1">
        <property type="nucleotide sequence ID" value="XM_001220271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFF3"/>
    <dbReference type="STRING" id="306901.Q2HFF3"/>
    <dbReference type="GeneID" id="4386789"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01051"/>
    <dbReference type="eggNOG" id="ENOG502RYYU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_6_1"/>
    <dbReference type="InParanoid" id="Q2HFF3"/>
    <dbReference type="OMA" id="LMCERFL"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="UniPathway" id="UPA00327"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035835">
        <property type="term" value="P:indole alkaloid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051604">
        <property type="entry name" value="Ergot_Alk_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019901">
        <property type="entry name" value="Ergot_alkaloid_biosynthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03649">
        <property type="entry name" value="ergot_EASG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162:SF1">
        <property type="entry name" value="PRESTALK A DIFFERENTIATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0017">Alkaloid metabolism</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="5">
        <location>
            <begin position="8"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ92816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="310" mass="33558" checksum="04DE1B222DD6D9D3" modified="2006-03-21" version="1">MPTSSQPAILVLGGTGTVGSRIVSQLAASSHPHRILVASRNTSKNAVAPKTDGPNVQPVPFDWHNTDTWDDLFSTTDNNKTNIAAVFLIAPPTLGAEQTMIDFVDLARSRGVPRFVLLSASPIEAGGPAMGKVHAYLRELGQRGEVEWAALRPTWFQQNFADLPFHVEGIKNDSKVYSATSDAKIPWVSADDIAAVAVRTLTDEVAPNSEYLVLGSELLSYGEIANILSEVLGRKIVHVDLSPEELEQRHQSFGMPEDYSRMMSAMDTSVKNGSENRTNDVILAVTGSVPRKFRDFALSVKEVWGTGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG09</accession>
    <name>Q2HG09_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Small ribosomal subunit protein uS17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">40S ribosomal protein S11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_00845</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220066.1">
        <property type="nucleotide sequence ID" value="XM_001220065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG09"/>
    <dbReference type="FunCoup" id="Q2HG09">
        <property type="interactions" value="992"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HG09"/>
    <dbReference type="GeneID" id="4387991"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00845"/>
    <dbReference type="eggNOG" id="KOG1728">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073626_0_2_1"/>
    <dbReference type="InParanoid" id="Q2HG09"/>
    <dbReference type="OMA" id="DYEKCPF"/>
    <dbReference type="OrthoDB" id="10254436at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000008">
        <property type="entry name" value="40S ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0164">Citrullination</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="10" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 16" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="15">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAQ92610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="122" mass="14066" checksum="9EA01ED072579E06" modified="2006-03-21" version="1">MATELTVQSERAFQKQPHIFLNSKTKVKSSRPGKGGRRWYKDVGLGFRTPTTAIEGQYIDKKCPFTGMVSIRGRILTGTVVSTKMHRTIIIRREYLHYIPKYNRYEKRHKNLAAHVSPGFPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG18</accession>
    <name>Q2HG18_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 12 kDa subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_00836</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220057.1">
        <property type="nucleotide sequence ID" value="XM_001220056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG18"/>
    <dbReference type="STRING" id="306901.Q2HG18"/>
    <dbReference type="GeneID" id="4386629"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00836"/>
    <dbReference type="eggNOG" id="ENOG502SBS6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142967_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HG18"/>
    <dbReference type="OMA" id="GYQKNDP"/>
    <dbReference type="OrthoDB" id="10252718at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039993">
        <property type="entry name" value="NDUFB10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE PDSW SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ92601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="12416" checksum="FCE362BD323D0CF4" modified="2006-03-21" version="1">MPTSRIPRAFLAKKPKVAPTFDGVDYDDTKRLKQAQDAVIREQWVQVMMGRLVREELSKCYYREGVNHLEKCGRLRERYLQLLGSAKVKGYLFEQQNYFSKDGAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGB2</accession>
    <name>Q2HGB2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CHGG_00742</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219963.1">
        <property type="nucleotide sequence ID" value="XM_001219962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGB2"/>
    <dbReference type="STRING" id="306901.Q2HGB2"/>
    <dbReference type="GeneID" id="4386947"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00742"/>
    <dbReference type="eggNOG" id="KOG0471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_7_2_1"/>
    <dbReference type="InParanoid" id="Q2HGB2"/>
    <dbReference type="OMA" id="VTNHMAW"/>
    <dbReference type="OrthoDB" id="204980at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF215">
        <property type="entry name" value="ALPHA-AMYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209234" description="alpha-amylase" evidence="17">
        <location>
            <begin position="20"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="18">
        <location>
            <begin position="32"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="14">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="49"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="420"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAQ92507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="462" mass="50231" checksum="0F26DEEBFAC5A27F" modified="2006-03-21" version="1">MRHPLLAAAAALCTSRISALPAASWRSQSIYQVVTDRFARTDLSTSAPCDPAAQVYCGGSWRGLIAKLDYIRGMGFTAVWISPVVAQVEVEGGLADGSSYHGYWAKDIWALNAAFGDENDLVELSAELHARDMYLMVDIVTNHMAWQPQASYYHSPCPIDYDSQTLVEVCWQGSDVVSEAVRSVWNEWVTEMVSKYSIDGLRVDSAKHVETSFWSGFSDAAGVYLLGEVFQGDPLYYWILNAFKSPDGSISELVSGLNTLRGVAQDPSLYGSFLENHDIERFPSFTEDTALVKNCSNRPWKGIPIIYQGQEQHYSGSGTPQNREALWSSGYSETAELYTWIAKLNQIRSQAISQDDGYLSYKSNPIYSDSHTIAMRKGQPGAQVVGVFTNVGTFSSAEATLPSSATGFEAGQALVDVMGCTEHTTDSGGGIAVTLASGLPVVLYPKARLSGSGVCDNSTRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGR2</accession>
    <name>Q2HGR2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_00592</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219813.1">
        <property type="nucleotide sequence ID" value="XM_001219812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGR2"/>
    <dbReference type="STRING" id="306901.Q2HGR2"/>
    <dbReference type="GeneID" id="4387113"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00592"/>
    <dbReference type="eggNOG" id="KOG1477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_500569_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGR2"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="63"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="4">
        <location>
            <begin position="366"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ92357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="544" mass="59781" checksum="6DEB1E1F689E77B7" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGW3</accession>
    <name>Q2HGW3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219762.1">
        <property type="nucleotide sequence ID" value="XM_001219761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGW3"/>
    <dbReference type="GeneID" id="4388074"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00541"/>
    <dbReference type="HOGENOM" id="CLU_1315258_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGW3"/>
    <dbReference type="OrthoDB" id="10375297at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="209" mass="22816" checksum="E2D310FDCD68BE8E" modified="2006-03-21" version="1">MSDSRRGTPRVSTSSQRPMARSWPLPAPPSGRSPKSCGTPARLAARNAAAHALPNARVTHHCPKTPASLPAPRALEPFVLQNLCSPRYPRHSDANNQLRRWAKGENKGSDRQQPTRRVDGRETGALRPASTPLSERHMPDHLSPTSPVLMQRAPTARTPNPPSHPSNRDRPSSMHQTAGSGSWSRGADVTLRVFSGLGRCGMERVVRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HH70</accession>
    <name>Q2HH70_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219655.1">
        <property type="nucleotide sequence ID" value="XM_001219654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HH70"/>
    <dbReference type="GeneID" id="4387682"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00434"/>
    <dbReference type="eggNOG" id="ENOG502S1B6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019843_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HH70"/>
    <dbReference type="OMA" id="SYQCTLR"/>
    <dbReference type="OrthoDB" id="5210591at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="53333" checksum="11C432DF0A2A367B" modified="2006-03-21" version="1">MCQPPTDDVARNMLGPVVPDDIVLGKLQLVPSVRPLRIYEVPIPGGKTLHLVLPPISMWRPLRAEQGMLSSEATTVRWIRETLARETATTEQKASSFSSVTRDITTSLLPLLPTLLRHGRETHLPNSSFAVYKPANGTPLSLLSSEPTPTVRREIDCQLGALFRHLNTLTSPTGRFGPLAAVIDTSSGPGTPQPAGSRAKTPRLPQVLTESGLSATGGAGTWSVAFHSMMEGVLRDGEDMAVVISYPTIRRHFRRLGYLLDDVTTARLVIVEGAGRGNVLVGDLGEQKEDTEKEKEVGDDGKESGKNKGKATDEKVTGEGEDDKEKGETDMTQKGDTQSQQSLKLTGLRDWSSAIFGDPLLASVFSDPHQPLPSSAFLEGFNGEKLESGADSQHTKLPYPLNPTVIENADTAWIRLLFYQVYHTVTRIVSEFYRPRQDSSTRELEARKKLNEVLAKLAEVPDNTKKRQQRPSGEMSPAKRLRGAEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHE2</accession>
    <name>Q2HHE2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_00362</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219583.1">
        <property type="nucleotide sequence ID" value="XM_001219582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHE2"/>
    <dbReference type="STRING" id="306901.Q2HHE2"/>
    <dbReference type="GeneID" id="4387829"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00362"/>
    <dbReference type="eggNOG" id="ENOG502RYSN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031730_4_2_1"/>
    <dbReference type="InParanoid" id="Q2HHE2"/>
    <dbReference type="OMA" id="HFYMAKV"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208960" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="18"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="18"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="169"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ92127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="228" mass="23837" checksum="F898D69CF6C37503" modified="2006-03-21" version="1">MKFASSVALLAAAGAQAHYTFPKTVVDGVTSAEWETIRITENHYSHGPVEDVSSSKMTCYQRDVGTGAAKTVSVKAGGTVGFTVDTSIGHPGPLHFYLAKVPSGQTAATFDGKGAVWFKIYEDGPSGLGTGNLKWPSDGKTQVSVKIPSCVQNGDTPPPKHLTNILPLTELYISCAQLSVTGGSGTINTGSLVSFPGAYKATDPGILFQLYWPIPTSYVNPGPPVVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHK6</accession>
    <name>Q2HHK6_CHAGB</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219519.1">
        <property type="nucleotide sequence ID" value="XM_001219518.1"/>
    </dbReference>
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    <dbReference type="STRING" id="306901.Q2HHK6"/>
    <dbReference type="GeneID" id="4386551"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00298"/>
    <dbReference type="eggNOG" id="ENOG502RA8Z">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1057682_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHK6"/>
    <dbReference type="OrthoDB" id="1523883at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209257" evidence="2">
        <location>
            <begin position="24"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ92063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="263" mass="29077" checksum="590635D810CF8898" modified="2006-03-21" version="1">MPTHPFPGLSLLVALRITPLISTTCTLLYARDQDFFLRLFNHPASHRAKSRPFLPSYWQAFFRRGIYLVVGCLGATFWSSLANLYVRRPMLHAKGRLGVTIVGEVTAAKFIPRTHSSLIVRHSPFILLRALLPILTLRRSQRPNMQVHITSPLRRPRGKEVMILPQRPSLTNIPDGRMGDVLTLAAQCQPFEEKSRGARRESGLLSTRTLHVAAQGGAVGKVGVHPAGEDAEFYRKPGGDLVVWGEGVEGRGRSSGRSGTCRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHP2</accession>
    <name>Q2HHP2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219483.1">
        <property type="nucleotide sequence ID" value="XM_001219482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHP2"/>
    <dbReference type="GeneID" id="4387618"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00262"/>
    <dbReference type="HOGENOM" id="CLU_2277176_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHP2"/>
    <dbReference type="OrthoDB" id="2733590at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="102" mass="11327" checksum="ED9089B75A74F22C" modified="2006-03-21" version="1">MSDLPIAHDRTDTEDGFEWEDAKSQNGVTFRIGRPTASQSQANPPATDSASPQIDPPPVKFQRVSVPVYWPTTAHQQWSKIHGDVRVGGLTDYALWPGGRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI08</accession>
    <name>Q2HI08_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_00146</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219367.1">
        <property type="nucleotide sequence ID" value="XM_001219366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HI08"/>
    <dbReference type="GeneID" id="4387272"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00146"/>
    <dbReference type="eggNOG" id="ENOG502RZVZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079143_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HI08"/>
    <dbReference type="OMA" id="DINFTHG"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="6">
        <location>
            <begin position="49"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ91911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="207" mass="23806" checksum="8591F9CD7A9343B9" modified="2006-03-21" version="1">MEDENGNKRSDGTEPHQYQAGSSTNREEDQWKERPPYKIHDKGQFDVKWKGKCHCGAVQYELSREKPLASKYCHCTTCQRLHGAPFQWATIFQKTDINFTNGHHDLGWYDPTHKSTTHHLPCKVQCAYCRTPIMDEGRNMILLFPTLIEGINTPKGKKAFEVQSHMFYQQRVVDVKDGKPKFEGLADQSARVDEETGEVMGTETLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HI77</accession>
    <name>Q2HI77_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ91842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219298.1">
        <property type="nucleotide sequence ID" value="XM_001219297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HI77"/>
    <dbReference type="GeneID" id="4388283"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00077"/>
    <dbReference type="eggNOG" id="ENOG502RS68">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_438039_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HI77"/>
    <dbReference type="OrthoDB" id="5095644at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="2">
        <location>
            <begin position="297"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ91842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="631" mass="71632" checksum="9C8F3B20ABBAF973" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GM52</accession>
    <name>Q2GM52_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">T-complex protein 1 subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_10952</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226219.1">
        <property type="nucleotide sequence ID" value="XM_001226218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GM52"/>
    <dbReference type="FunCoup" id="Q2GM52">
        <property type="interactions" value="1263"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GM52"/>
    <dbReference type="GeneID" id="4397327"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10952"/>
    <dbReference type="eggNOG" id="KOG0363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_6_2_1"/>
    <dbReference type="InParanoid" id="Q2GM52"/>
    <dbReference type="OMA" id="CAEMVMS"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03336">
        <property type="entry name" value="TCP1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000002">
        <property type="entry name" value="T-complex protein 1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000045">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012716">
        <property type="entry name" value="Chap_CCT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ83134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="529" mass="56803" checksum="C3A6ED6085FD322F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMH3</accession>
    <name>Q2GMH3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226098.1">
        <property type="nucleotide sequence ID" value="XM_001226097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMH3"/>
    <dbReference type="GeneID" id="4397091"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10831"/>
    <dbReference type="eggNOG" id="ENOG502SDNZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_25_0_1"/>
    <dbReference type="InParanoid" id="Q2GMH3"/>
    <dbReference type="OrthoDB" id="3437859at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="41687" checksum="A72C7A4CBF479AA7" modified="2006-03-21" version="1">MPAHQCLFFLHLTAVRKKMKTQIYALTRLAAKTWGCTFARVREIYSKVIRSAIAYGASAFHTPTEVGPPRGAAKELAKIQSECLRVVAGAYKATPIQSLETETYCPPIDLYPNKRLLAFEDRVRISEEARLILQTPATIAAILRRRRRRGRGRPRREVADIATAPAEKGSGEWKKRWAQEWAPLESRPEKEELEPGSTGPGPNHKKQLERWMEEAMRREWIGRWESEVARVVARNPGRALEPADATARFDASIMNRHRSRDPAWELSKAKSTLLVQARTGKIGLRGFLFTRRVPEVVTPVCRCGMARETFKHLVLECNGAADKPQPWPDDGAELLEWLDDVEKAAIVVRWVLGLGRLNEFRLAVELGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMI5</accession>
    <name>Q2GMI5_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_10819</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226086.1">
        <property type="nucleotide sequence ID" value="XM_001226085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMI5"/>
    <dbReference type="STRING" id="306901.Q2GMI5"/>
    <dbReference type="GeneID" id="4397178"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10819"/>
    <dbReference type="eggNOG" id="KOG4534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_880104_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GMI5"/>
    <dbReference type="OMA" id="TDGAWEF"/>
    <dbReference type="OrthoDB" id="3361892at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032931">
        <property type="term" value="F:histone H3K56 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013178">
        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016849">
        <property type="entry name" value="Rtt109"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF2">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE RTT109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08214">
        <property type="entry name" value="HAT_KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51728">
        <property type="entry name" value="RTT109_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="107"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="267"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ83001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="337" mass="37199" checksum="9D32E8E4F2F42921" modified="2006-03-21" version="1">MRAFIPRASASLTNWVIGHPLELISHYTRDFNSVPPRCLIPGYPDDPKSRFRDELDEEVSKQNHNIGAWKSVRSLEQFWEMMAFRQECSSGRLTGFIWLVFDSSEPSSNAPSAGRPETKLTAPKAPSDLSLPPVMPATPPRRQLAISTSDTTPPPRPSKAPAKKPRKKAKKKLLGRIVPRTPKIKTHARSYKANRPTVTAYYYWPREARGDKLVEEAEYKRIVDLLLHLDFSTLDKTVGSSTRWLNEVGMGDGGEWGVVAGKAAIPSSPRVSDTTSNTSGNVTNLTGLIRRKNAPAPSEPGNSQQPDSAAKEPTEPAKVNVLGTNLVRKRKKGAEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMX4</accession>
    <name>Q2GMX4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF829 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228607.1">
        <property type="nucleotide sequence ID" value="XM_001228606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMX4"/>
    <dbReference type="ESTHER" id="chagb-q2gmx4">
        <property type="family name" value="Duf_829"/>
    </dbReference>
    <dbReference type="GeneID" id="4397058"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10680"/>
    <dbReference type="eggNOG" id="ENOG502S6B9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_474863_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GMX4"/>
    <dbReference type="OMA" id="DEFIRPR"/>
    <dbReference type="OrthoDB" id="77878at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265:SF40">
        <property type="entry name" value="DUF829-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="63040" checksum="DA25BF7642FCD0C9" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN53</accession>
    <name>Q2GN53_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Armadillo-like helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_10601</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228528.1">
        <property type="nucleotide sequence ID" value="XM_001228527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN53"/>
    <dbReference type="GeneID" id="4396156"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10601"/>
    <dbReference type="eggNOG" id="KOG4654">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029861_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GN53"/>
    <dbReference type="OMA" id="YEATHLN"/>
    <dbReference type="OrthoDB" id="2012278at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039868">
        <property type="entry name" value="ARMD3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013636">
        <property type="entry name" value="ARMH3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608:SF3">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08427">
        <property type="entry name" value="ARMH3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01158">
        <property type="entry name" value="DUF1741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Armadillo-like helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ84197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="686" mass="75965" checksum="EFE00CD0B8B282FB" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNM2</accession>
    <name>Q2GNM2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228359.1">
        <property type="nucleotide sequence ID" value="XM_001228358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNM2"/>
    <dbReference type="GeneID" id="4396928"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10432"/>
    <dbReference type="HOGENOM" id="CLU_2812126_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GNM2"/>
    <dbReference type="OrthoDB" id="5243754at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="67" mass="7595" checksum="5F586BE8669DEAAC" modified="2006-03-21" version="1">MAKLNTYLHRIKAAPSDQWGNLSFYLGGKSPSDDKDWSPNMRAVRATIRFAIATGRLRTEQQQNEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GP23</accession>
    <name>Q2GP23_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_10281</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228208.1">
        <property type="nucleotide sequence ID" value="XM_001228207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GP23"/>
    <dbReference type="FunCoup" id="Q2GP23">
        <property type="interactions" value="1301"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GP23"/>
    <dbReference type="GeneID" id="4396168"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10281"/>
    <dbReference type="eggNOG" id="KOG0925">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_5_11_1"/>
    <dbReference type="InParanoid" id="Q2GP23"/>
    <dbReference type="OMA" id="MKVYPLY"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17973">
        <property type="entry name" value="DEXHc_DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001148">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15/PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000003">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044756">
        <property type="entry name" value="DHX15_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF109">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="106"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="296"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ83877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="763" mass="86805" checksum="2573BC4F32F64150" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPD2</accession>
    <name>Q2GPD2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_10172</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228099.1">
        <property type="nucleotide sequence ID" value="XM_001228098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPD2"/>
    <dbReference type="STRING" id="306901.Q2GPD2"/>
    <dbReference type="GeneID" id="4396564"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10172"/>
    <dbReference type="eggNOG" id="KOG0884">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_16_3_1"/>
    <dbReference type="InParanoid" id="Q2GPD2"/>
    <dbReference type="OMA" id="VPFHRVM"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01928">
        <property type="entry name" value="Cyclophilin_PPIL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000041">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="6"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ83768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="167" mass="18077" checksum="E25B1FF1005080D2" modified="2006-03-21" version="1">MSVTLHTTHGDLKVEVFCESVPKTAENFLALCASSYYDASPFHRLIPSFMAQTGAPANPNPPDNPKGGRSIYGPTFEDEIRPGLRHHERGVLSMANKGANTNGSQFFVTFAAAPHLDGINTVFGKLLGDESLATLARIEAVEVDKKNRPLEPVRIERVTVHANPLAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2026-01-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPT6</accession>
    <name>CCDC_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetyltransferase ccdC</fullName>
            <ecNumber evidence="1">2.3.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Cochliodone A biosynthesis cluster protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ccdC</name>
        <name type="ORF">CHGG_10018</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2025" name="J. Am. Chem. Soc." volume="147" first="11555" last="11563">
            <title>Mechanism of Unexpected In-Trans Post-PKS Polyketide Reduction in Cochliodone Biosynthesis.</title>
            <authorList>
                <person name="Sarmales-Murga C."/>
                <person name="Sato M."/>
                <person name="Kosaka M."/>
                <person name="Akaoka F."/>
                <person name="Watanabe K."/>
            </authorList>
            <dbReference type="PubMed" id="40111931"/>
            <dbReference type="DOI" id="10.1021/jacs.5c03717"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="1 4">Acetyltransferase; part of the gene cluster that mediates the biosynthesis of cochliodone A, a dimerized azaphilone (PubMed:40111931). Within the pathway, ccdC takes part in the C10 reduction step and more specifically catalyzes the acetylation of the C10/C11 alcohol formed earlier by ccdN and kept unmodified during the azaphilone core formation by ccdF (PubMed:40111931). The pathway begins with the NR-PKS ccdL, the short-chain dehydrogenase ccdN, and the FAD-dependent monooxygenase ccdF that work in sequence to generate the pyranoquinone intermediate of the pathway. CcdL produces a benzaldehyde intermediate from the condensation of 5 malonyl-CoA units and one methylation, ccdN reduces the C11 carbonyl to an alcohol and ccdF completes the azaphilone core formation. The acetyltransferases ccdC, the acetate lyase ccdG and the trans-enoyl reductase ccdH then work in sequence to fully reduce the C10 position. CcdC is responsible for the acetylation of the C10/C11 alcohol formed earlier by ccdN and kept unmodified during the azaphilone core formation by ccdF, ccdG then performs the elimination of the C10 acetate group to generate the C9-C10 olefin, and ccdH eliminates the olefin to effect a full reduction of the polyketide backbone at C10. The O-acyltransferase ccdM is then responsible for the O-acetylation at C7 of the azaphilone core. CcdB might be responsible for the formation of the spiroacetal group. The remaining enzymes ccdO, ccdJ and ccdE catalyze the final steps of the biosynthesis of dimeric cochliodones. The enoyl reductase ccdO performs the reduction of the C1-C8a olefin to generate the enol necessary for dimerization, the multicopper oxidase ccdJ is responsible for the dimerization reaction that results in the formation of cochliodones from azaphilone monomers, and lastly, the FAD-dependent oxidase ccdE catalyzes the elimination of the enol to stabilize the compound for the generation of cochliodone A.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="1">Leads to a complete loss of production of cochliodone A and to the accumulation of the C10- and C10'-hydroxylated derivative of cochliodone J as well as to dihydroxylated cochliodone A.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trichothecene O-acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.-" evidence="1"/>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227945.1">
        <property type="nucleotide sequence ID" value="XM_001227944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPT6"/>
    <dbReference type="STRING" id="306901.Q2GPT6"/>
    <dbReference type="GeneID" id="4395929"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10018"/>
    <dbReference type="eggNOG" id="ENOG502TK9U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029138_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GPT6"/>
    <dbReference type="OMA" id="TGREHWG"/>
    <dbReference type="OrthoDB" id="2548233at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034:SF1">
        <property type="entry name" value="CONDENSATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000462667" description="Acetyltransferase ccdC">
        <location>
            <begin position="1"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="40111931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="40111931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="40111931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ83614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="426" mass="47481" checksum="7BD50AFE08EB5AF0" modified="2006-03-21" version="1">MVWAKTDSGTWRDEYDGAEKVFYQMSQAFKRHYREHGSVYAICRVRTSSGPGPLLGEQLMQAWTRLRFDFPGLAVFEDGGKKTYLEATAANVKSWINDTFWVDDEADAARHVATGLHLRKLPCLVFVSRSSEVLFHCSHWRIDALGTCVVLDRLFSILAQLTEGTVPGALESICWELEREHLPVSLEDAYGSAKEPTPKTEAKAEEIRQRNFITAYPTAGLPYQGDKSDLPRASRCQTVTFSKDQSEQFIQACKARGFTVTAAVHAACAASVLDSITYTLQRSDDFGSWCRQLTSGYRGDWDPPAYMDALRSIYRIHGETLADLAASGARPPASNVTVSSLGVIDHKYLRADHGVVQVEAFHLGSTIMGRQPTLYIWTFRGCLTLSVDFNEAYYSLGQISTLLDNIASCLSKEMGVDMSRSREGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPX0</accession>
    <name>Q2GPX0_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_09984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227911.1">
        <property type="nucleotide sequence ID" value="XM_001227910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPX0"/>
    <dbReference type="GeneID" id="4396539"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09984"/>
    <dbReference type="HOGENOM" id="CLU_2589545_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPX0"/>
    <dbReference type="OrthoDB" id="5130600at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ83580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="80" mass="9677" checksum="D82B2D90B97D4191" modified="2006-03-21" version="1">MGVALHTDARYSVKYVTERITRKLGRWMKSQNPEDQKILDEDLRILAEWSIKLDWHLHCNHQMFDFRFRDPATKKPYGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQA2</accession>
    <name>Q2GQA2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227779.1">
        <property type="nucleotide sequence ID" value="XM_001227778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQA2"/>
    <dbReference type="STRING" id="306901.Q2GQA2"/>
    <dbReference type="GeneID" id="4395989"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09852"/>
    <dbReference type="eggNOG" id="ENOG502S1WE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1331810_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQA2"/>
    <dbReference type="OMA" id="CEFIWIN"/>
    <dbReference type="OrthoDB" id="722566at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12014">
        <property type="entry name" value="Cyclin_D1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="206" mass="23153" checksum="BF99E56FC4E044DF" modified="2006-03-21" version="1">MPRHTCVKIDEDIETYSTLDPAQYTPTPTRPFRGIFVGDYGVHGCEFIWINQPDDDDDDDDDDDDDDDGNTPPSIERAEGESDEDYAARQLHAAIYRGRLEAVKLTGDANVPRGEYTFVVDDLGEAGFVREETKDPFARARLVRSRAQLANNGFRDATFTDAELFIISPDLLAHNWLALGHISYLRRVDIDRFIFPVEHGAGMSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQS4</accession>
    <name>Q2GQS4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PAZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227607.1">
        <property type="nucleotide sequence ID" value="XM_001227606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQS4"/>
    <dbReference type="STRING" id="306901.Q2GQS4"/>
    <dbReference type="GeneID" id="4396438"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09680"/>
    <dbReference type="eggNOG" id="KOG1041">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_652116_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQS4"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="1">
        <location>
            <begin position="68"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="421" mass="47900" checksum="9B0A121B9F19BD4A" modified="2006-03-21" version="1">MHQSYNTGGMGLGVNVDVANQTFWVGQKFEQLARNFLSCMDRKWDNLDYEGLRKALLPVKVGGKGGADAWGMSEAFKALRRLQNIRFEVKHRGDSKASKEHKVKGFAFDVKYGELGANAKAVTFNKKMPDGSTKTYSIADYYLQHYKTRIQHWYLPLIESTNAGLFPMEVCEVHRFNPYPFKLDPNQTSEMIKFAVQRPPQRKAEVLKMVQNLEWGQDRYLAHFGIKINPTMPMIPAKVLPNPVIQYAGRPVDPKMTGRWDLRGVKFVLPNKVPLTSWAFVIVDNCIDKTTAENFAKVFKTTYAGHGGKIVNDPKIYAPPRGVPVDQIVRGCYQRCGQENKFTPQIIFYILRDKTAFVYDRFKQANDCGVACLSQMLQAQHVRKAQGQYCSNVCMKVNSKLGGQTSKIASRARRIFEHIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQV5</accession>
    <name>Q2GQV5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_09649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227576.1">
        <property type="nucleotide sequence ID" value="XM_001227575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQV5"/>
    <dbReference type="GeneID" id="4396075"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09649"/>
    <dbReference type="HOGENOM" id="CLU_2222970_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQV5"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ83245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="106" mass="12434" checksum="B2777449E07CB6D6" modified="2006-03-21" version="1">MDHGYKLRLRFPRALLSYRRSREQWTVPPLPVKVIRNYETWDLTGISFTMSRPISPSKVEGLDIEINCQTHPSGERRTVLESQQLRIDCTKVIGCQKVMKERQPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQX2</accession>
    <name>Q2GQX2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MED9</name>
        <name evidence="10" type="ORF">CHGG_09632</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227559.1">
        <property type="nucleotide sequence ID" value="XM_001227558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQX2"/>
    <dbReference type="STRING" id="306901.Q2GQX2"/>
    <dbReference type="GeneID" id="4396561"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09632"/>
    <dbReference type="eggNOG" id="ENOG502SW8C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1266734_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQX2"/>
    <dbReference type="OrthoDB" id="5414694at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011425">
        <property type="entry name" value="Med9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07544">
        <property type="entry name" value="Med9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="167"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="178"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ83228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="218" mass="22465" checksum="E5407054CF83B8FB" modified="2006-03-21" version="1">MATHLPAGLSPDSVDVRSDTERRQLNPTINNNTNPSSSTTTNQQQHPHPLSHAPNSNTGTTPKPHHPGGTSTTTGPTTTTTSNPDPDAQLLSVKELPSATDGLKHKLQRARAAVRTLGDVRRAVAQQEAEMRALEGRRAAQARALARAQADGSGFCEGGGAWVVGGRGGGGGKGRGRVGGEGDGKDMLVSRGGERETGDGGLRDKKMDGGGNGLVDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GR12</accession>
    <name>Q2GR12_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227519.1">
        <property type="nucleotide sequence ID" value="XM_001227518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GR12"/>
    <dbReference type="GeneID" id="4396127"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09592"/>
    <dbReference type="eggNOG" id="ENOG502SQG8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035845_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GR12"/>
    <dbReference type="OMA" id="GPIYQRR"/>
    <dbReference type="OrthoDB" id="5315820at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="411" mass="42539" checksum="BCCA8CC632C8F144" modified="2006-03-21" version="1">MPVATSGTPTSTTTSLSALSTTAIKDGHRGALHHRGHQHSPSANSLEAERADRISRLTGLSSVSTLRGPPPGLAQYNDNAFQTTPTLAGFNANAISAATAAGLSPAYFNAAGQPVAATKVSTVGSASATESVGGRTNTTTEVGDDNSTLGEDRDEDMLTEMDSVSASGYMGGDNDAMDEDLDNLTSRSVGGYEDRMSDDGNASLVGFGEGAGSTLSGPIYHRRPLPWQNSGASGTGPAPNWGLERSSSGLSETAMASPNPHHTGSGSGRRDFAVRAPTERDTGSDTPVSQSAVRERREARMMDGVTLDNTDPPVSAASSGTAGDVFVDTTTRGPLPVQPTTPATTAAPATANPAQERRRRHGAPHHPHATSQLRHLEPTAPTSPREAAERIVRERLDQGEGRIGKRGLGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRZ0</accession>
    <name>Q2GRZ0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227191.1">
        <property type="nucleotide sequence ID" value="XM_001227190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRZ0"/>
    <dbReference type="STRING" id="306901.Q2GRZ0"/>
    <dbReference type="GeneID" id="4395646"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09264"/>
    <dbReference type="eggNOG" id="ENOG502S3EP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121050_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRZ0"/>
    <dbReference type="OMA" id="WGYRQFA"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="10"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="139" mass="15581" checksum="4165310B649303DE" modified="2006-03-21" version="1">MTNRNQVQSAWKIIPHFRSDNIQATVDFYTQVLGFTVGGVHTDGQSGQQTFCSLYAGDKAAANIYFSRDVAESSAWIALGTTELDDFYRELKSHGNVEIIEEIADKEWGYRQFKIRDTDGNRLTFFKFLAGGNPGVDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSF7</accession>
    <name>Q2GSF7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_09097</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001227023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSF7"/>
    <dbReference type="FunCoup" id="Q2GSF7">
        <property type="interactions" value="243"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GSF7"/>
    <dbReference type="GeneID" id="4395232"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09097"/>
    <dbReference type="eggNOG" id="ENOG502QQXX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006632_1_2_1"/>
    <dbReference type="InParanoid" id="Q2GSF7"/>
    <dbReference type="OMA" id="IAINWWD"/>
    <dbReference type="OrthoDB" id="2264294at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="331"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="692"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="727"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="697"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ85083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="770" mass="84140" checksum="065431CA2409DC96" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSJ6</accession>
    <name>Q2GSJ6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methanethiol oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_09058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226985.1">
        <property type="nucleotide sequence ID" value="XM_001226984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSJ6"/>
    <dbReference type="STRING" id="306901.Q2GSJ6"/>
    <dbReference type="GeneID" id="4395919"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09058"/>
    <dbReference type="eggNOG" id="ENOG502RXCX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028693_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GSJ6"/>
    <dbReference type="OrthoDB" id="10033702at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ85044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="36810" checksum="4D4B6B13872D420F" modified="2006-03-21" version="1">MCRNQGNIMHVSSTRDTFGTLLWITDVPSSGNDPHHLGPSLDGKTLVGGGLLSLLKTQDTAFYFDTTNPYRPTFKKSNRALLSSIADEIRAKPDGGFYITYMGSAVGTSPGRLVETDADFNIIHEWPQDVESTLNILGEQFNPHGLSIDWERKNILTSDFVEPRSLSIRSLMNVQGGGIQDVKHIPGNPEGAALATAVHLGQVWIIYPERKDAHGKPGVAELLFDLGPKARDTVAIYAWTTPTKEQPTIGPHYVKVTPDQKHLVVTDYFVQTGNLGLINTPADFKALYVDILDDGSLSFNRSIDFQREFANRGGAKPHSSVIFDLTDPENPLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GST4</accession>
    <name>Q2GST4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_08970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001226896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GST4"/>
    <dbReference type="GeneID" id="4395381"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08970"/>
    <dbReference type="eggNOG" id="ENOG502SJBC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002786_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GST4"/>
    <dbReference type="OMA" id="WTFYETI"/>
    <dbReference type="OrthoDB" id="361039at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050829">
        <property type="entry name" value="CorA_MIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47685">
        <property type="entry name" value="MAGNESIUM TRANSPORT PROTEIN CORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47685:SF1">
        <property type="entry name" value="MAGNESIUM TRANSPORT PROTEIN CORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="986"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1029"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="343"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="678"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="838"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1123"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="384"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="838"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="864"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1125"/>
            <end position="1138"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ84956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1145" mass="129205" checksum="ECDBB8189F47D533" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSU2</accession>
    <name>Q2GSU2_CHAGB</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">CHGG_08962</name>
    </gene>
    <organism evidence="3 4">
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        <name type="common">Soil fungus</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226889.1">
        <property type="nucleotide sequence ID" value="XM_001226888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSU2"/>
    <dbReference type="GeneID" id="4395891"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08962"/>
    <dbReference type="eggNOG" id="ENOG502RJ7B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_829447_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GSU2"/>
    <dbReference type="OMA" id="WARMQAS"/>
    <dbReference type="OrthoDB" id="4571782at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="277" mass="31303" checksum="08BB7B13F3B4D983" modified="2006-03-21" version="1">MHRCTLFFRLRPRSIPGDDDDEVADAVDGTNINEKCSRRPRDWPALFLTVLRFLQFAYFAFAYFALHGFQRSSYFHEDGPWQQSPHEIRHAQRMMRWARMQASISLIYHAGVLIVPWLLRLLRATKRPFTGLGAVFGDGCAMVALLNTLCTLDTAHEGYCHSPPPRGVITKVLPAGDIEQGVIQGPVREEARASAMHQRRPSPPPSYHSVIPEPAQDDQDYAGRTTPSQELRSRASVETTSSLGLERYGYLVSDGWRAPEQPPMYSSRPPSLRQVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSY4</accession>
    <name>Q2GSY4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rad4 beta-hairpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ84906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001226846.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="Q2GSY4">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GSY4"/>
    <dbReference type="GeneID" id="4395209"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08920"/>
    <dbReference type="eggNOG" id="KOG2179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003639_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GSY4"/>
    <dbReference type="OMA" id="VDEYAMD"/>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="2">
        <location>
            <begin position="558"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="36"/>
        </location>
    </feature>
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        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
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        <location>
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            <end position="371"/>
        </location>
    </feature>
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            <begin position="401"/>
            <end position="410"/>
        </location>
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            <begin position="418"/>
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        </location>
    </feature>
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        <location>
            <begin position="473"/>
            <end position="488"/>
        </location>
    </feature>
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        <location>
            <begin position="498"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="734" mass="80553" checksum="C3FAE44E5AB3F6DE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GT68</accession>
    <name>Q2GT68_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CHGG_08836</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226763.1">
        <property type="nucleotide sequence ID" value="XM_001226762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GT68"/>
    <dbReference type="GeneID" id="4395564"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08836"/>
    <dbReference type="eggNOG" id="ENOG502T1TT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_642494_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GT68"/>
    <dbReference type="OrthoDB" id="4581787at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="427" mass="46839" checksum="193F1A9E3D0CF7ED" modified="2006-03-21" version="1">MANATRKRAGWDPSQKGSWARRHGSAGENKLGGKPLMANNRAISNHPRPLYADHYPSSSSFLGDTSNDEGQIFEANPRGIKTLQLGVGIPKSRTFSVISSLTQSLSHGTIVRQGVSRNVSREPHDQTSNHRLVTQHTLSPKARQASTYQAPATPTLPPGQSNNIEAVSTAMPPQYWAGRFMALHDRFHNELLEPYHLTRLCEAQAAHPLADFTRPASAATQNNPSTSAYSIPRSTAKSQTSHPRQPSSSHSRIPQSATSGAILQSTSYNLQPDPLSNLHATSASSSVRKLTTTTTTASYRRRNPQHHHHPLPTTDENSIPEHPPTGNTTTTTIPKTNKTPPPTHQNPNQNRVLTTHLADDEASRVRRVLLRLEYMCETDAARLSLRQWRVAYARRTGRGEFLPLCHSDGGGRVVQTGRVAGERRAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GT88</accession>
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        <recommendedName>
            <fullName evidence="5">NEK6-subfamily protein kinase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_08816</name>
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    <organism evidence="9 10">
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.34" evidence="5"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226743.1">
        <property type="nucleotide sequence ID" value="XM_001226742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GT88"/>
    <dbReference type="GeneID" id="4394866"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08816"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_363284_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GT88"/>
    <dbReference type="OMA" id="DQCYFDF"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289:SF6">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEKL-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="247"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="577"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="630"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="649"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="698"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="732"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ84802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="769" mass="84195" checksum="029E3E0CAADCFF20" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTE3</accession>
    <name>Q2GTE3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226688.1">
        <property type="nucleotide sequence ID" value="XM_001226687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTE3"/>
    <dbReference type="GeneID" id="4395825"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08761"/>
    <dbReference type="eggNOG" id="ENOG502T27G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068316_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GTE3"/>
    <dbReference type="OMA" id="TAKMQRQ"/>
    <dbReference type="OrthoDB" id="5366332at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="295" mass="33139" checksum="4EAD195DFA1AC074" modified="2006-03-21" version="1">MAATSHLSHLTTIDRPDSRVSLARSDSTYHSFQDIDLPEPEVPSWPVQKPIVCPPRPSPGPKEEPRPMAREMRRQDSGYESIAPQESLPSRQRTSSSNSLSSSTRQRRTRPPNHRSPKSGPVSHRPRNGRHSVSPPGSSRSLASQPQQPVTYFHFPHFTSSDPTLVETDGAVVARQNAKDFASTPSFALEAPAYPLPPQTTHYWTSDRTRRLEYAAIDAASNGVRGWVMRHVVPDCFVPQSKRRVGFEDDRGSVVRYRLELDDREEASAAAAAAEKPDEVRVRGWKGWLFSMRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTG0</accession>
    <name>Q2GTG0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_08744</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226671.1">
        <property type="nucleotide sequence ID" value="XM_001226670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTG0"/>
    <dbReference type="STRING" id="306901.Q2GTG0"/>
    <dbReference type="GeneID" id="4395570"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08744"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_17_8_1"/>
    <dbReference type="InParanoid" id="Q2GTG0"/>
    <dbReference type="OMA" id="WYEMDGD"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001530">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="694"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="737"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="816"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="842"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="924"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="44"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="345"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="698"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ84730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1112" mass="121538" checksum="DF6DB29C476346AB" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GTK7</accession>
    <name>Q2GTK7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_08697</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226624.1">
        <property type="nucleotide sequence ID" value="XM_001226623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GTK7"/>
    <dbReference type="FunCoup" id="Q2GTK7">
        <property type="interactions" value="970"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GTK7"/>
    <dbReference type="GeneID" id="4394968"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08697"/>
    <dbReference type="eggNOG" id="KOG0546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_37_0_1"/>
    <dbReference type="InParanoid" id="Q2GTK7"/>
    <dbReference type="OMA" id="EMEQNCN"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000029">
        <property type="entry name" value="peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000009">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="8 11" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="14"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="311"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ84683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="374" mass="40518" checksum="E8FB7400AC9FB8D9" modified="2006-03-21" version="1">MSTDEAKQARSRVFFDITIGGQSAGRVTFELFNDIVPKTAENFRALCTGEKGIGKAGKPLHFKGSAFHRVIKQFMIQGGDFTAGNGTGGESIYGAKFADENFELKHDRPFLLSMANAGPGTNGSQFFVTTVATPHLDSKHVVFGEVLSGKSVVRQIENLRTQSDKPIKDAVIADCGELSPSEAVAADIKAPDAYGDDYEDFPEDQTTGDEPLSASKIAKIASDCKDFGNKAFKAGDFSVALDKYQKGLRYLNEDPDLDNEPAETKEKLDALRMSLNSNAALMNIKLCAWDETIRAAESGLAVPKISDKDKAKLLYRRGVALVRLKDEDAALESLEQAKKLNPEDAAINAELNSVKKAAAARLAKEKAAYSKFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU91</accession>
    <name>Q2GU91_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_08463</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226390.1">
        <property type="nucleotide sequence ID" value="XM_001226389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GU91"/>
    <dbReference type="STRING" id="306901.Q2GU91"/>
    <dbReference type="GeneID" id="4395349"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08463"/>
    <dbReference type="eggNOG" id="ENOG502SJ6A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024934_0_2_1"/>
    <dbReference type="InParanoid" id="Q2GU91"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF7">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="458"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ84449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="584" mass="66170" checksum="57DD93F290574BF4" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUI4</accession>
    <name>DBP3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent RNA helicase DBP3</fullName>
            <ecNumber>3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DBP3</name>
        <name type="ORF">CHGG_08370</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226297.1">
        <property type="nucleotide sequence ID" value="XM_001226296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUI4"/>
    <dbReference type="SMR" id="Q2GUI4"/>
    <dbReference type="FunCoup" id="Q2GUI4">
        <property type="interactions" value="348"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GUI4"/>
    <dbReference type="GeneID" id="4394736"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08370"/>
    <dbReference type="eggNOG" id="KOG0331">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_5_1"/>
    <dbReference type="InParanoid" id="Q2GUI4"/>
    <dbReference type="OMA" id="KKTHDMY"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000464">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000255992" description="ATP-dependent RNA helicase DBP3">
        <location>
            <begin position="1"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="212"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="433"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box">
        <location>
            <begin position="342"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="225"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="566" mass="61661" checksum="AE3CCB0FD617ACD7" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUI7</accession>
    <name>Q2GUI7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226294.1">
        <property type="nucleotide sequence ID" value="XM_001226293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUI7"/>
    <dbReference type="STRING" id="306901.Q2GUI7"/>
    <dbReference type="GeneID" id="4394733"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08367"/>
    <dbReference type="eggNOG" id="ENOG502T65Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_868787_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUI7"/>
    <dbReference type="OrthoDB" id="4587908at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208638" evidence="2">
        <location>
            <begin position="24"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ84353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="320" mass="31319" checksum="90CDDCB431C1616F" modified="2006-03-21" version="1">MAVAKILPLVSLVLSAFFSGILAEGGGHLGKRTALSDRGVGTCHIEGWVPACPGGVCCSDGTTYALGAETCPEGASPLPGAGSGAGSGAGSGYGSGFGSGSGGNPDSDFAGGPGGPGAQSQDASDPTTTAPPHPHPDPLGPDVGPDFLGFGSNWYTFSMTFHFLSHWYSLIDHTSSVLVSSEIFSCSTVSVSATDAAEASAIFSSISATAALAAPIETQALLPVPGKSQPPSAFPIETHAPVAPPPPVDAVGSLVSVNPVVSDPPAPAATGGWRLPANGTVGTAKPPPSPVVTAGSSRIRGFGGVVVGVAALVLGKVVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUJ9</accession>
    <name>Q2GUJ9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aggrecan core protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226282.1">
        <property type="nucleotide sequence ID" value="XM_001226281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUJ9"/>
    <dbReference type="STRING" id="306901.Q2GUJ9"/>
    <dbReference type="GeneID" id="4394751"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08355"/>
    <dbReference type="eggNOG" id="ENOG502SVUK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013165_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUJ9"/>
    <dbReference type="OMA" id="SVTHMAD"/>
    <dbReference type="OrthoDB" id="6090458at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208639" description="Aggrecan core protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ84341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="653" mass="68401" checksum="D634BAC1BFCCFDE4" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUN7</accession>
    <name>Q2GUN7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ87064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225973.1">
        <property type="nucleotide sequence ID" value="XM_001225972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUN7"/>
    <dbReference type="STRING" id="306901.Q2GUN7"/>
    <dbReference type="GeneID" id="4393912"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08317"/>
    <dbReference type="eggNOG" id="ENOG502SPZ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070871_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GUN7"/>
    <dbReference type="OMA" id="GAMFHDL"/>
    <dbReference type="OrthoDB" id="2378324at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569:SF1">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208209" description="HD domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="29136" checksum="43B5B5AC345C8ED6" modified="2006-03-21" version="1">MLGINFISGVRLILTACLLSSISQASLIPSNPLGARGLKPYPRRTLGGVSVVDTPIVRAAEAFARQNGQDFTYKHIMRSWLFGALVIQHNETLRATIDLEVHAVAALLHDLGWDQTDGSPMVSADRRFEVDGAIAARNFIRDHRDGKRWEERRVQLVWDAIALHTQQSIALFKELDVQVVHKGIITDFDGPQLGITKDEYAAVVKEFPRDDLRDGLNETVIWLCSTKPASTYDTWMQPWGEAYVANYSAVGSRLFDRPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUS2</accession>
    <name>Q2GUS2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptide transporter PTR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_08282</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ87029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225938.1">
        <property type="nucleotide sequence ID" value="XM_001225937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUS2"/>
    <dbReference type="GeneID" id="4393126"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08282"/>
    <dbReference type="eggNOG" id="KOG1237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004790_4_3_1"/>
    <dbReference type="InParanoid" id="Q2GUS2"/>
    <dbReference type="OMA" id="RFKLICW"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="522"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ87029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="68640" checksum="C83C2FA8D456C832" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVG2</accession>
    <name>Q2GVG2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_08042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225698.1">
        <property type="nucleotide sequence ID" value="XM_001225697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVG2"/>
    <dbReference type="STRING" id="306901.Q2GVG2"/>
    <dbReference type="GeneID" id="4394171"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08042"/>
    <dbReference type="eggNOG" id="ENOG502SI41">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1669183_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GVG2"/>
    <dbReference type="OrthoDB" id="294702at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ86789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="158" mass="17279" checksum="10E5D1100A0825A4" modified="2006-03-21" version="1">MATHTNADFLNDPRFNQTFEYIPPVLSTKDALAIKHKIRIISTDRPGMGGTDAVAPKDRLTVWRDAGGVPEGWRAGSVRLEVFYAETDTLTGDGGVASKPGKWFDGLWEGGVRDVVDYGSKTVKGADHDGIWWLRWGAVQQVFEAAGGAGERDEARDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GVL9</accession>
    <name>Q2GVL9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_07985</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peroxin-14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225641.1">
        <property type="nucleotide sequence ID" value="XM_001225640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GVL9"/>
    <dbReference type="GeneID" id="4393582"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07985"/>
    <dbReference type="eggNOG" id="ENOG502S3Q3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044743_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GVL9"/>
    <dbReference type="OMA" id="CDGLIYS"/>
    <dbReference type="OrthoDB" id="441517at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0811">Translocation</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="9">
        <location>
            <begin position="38"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ86732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="349" mass="38512" checksum="4CCE408E304DFB41" modified="2006-03-21" version="1">MGESEEENKQEVLSKPQDQQGAAPAPSPSPEAEQTTPREETLAQAKKFLQDAEVQNTTPERKAEFLKSKGLADSDIEGLLNEVTQDGRQESQPSIPEERIEPPLSKKEDRPPIVTYPEFLTKPERPPPLVTVNRFLNTLYAFGGLSTIVYGASKFVVEPMVHTLTEARISLHDTANQDLAKLVAKLETVVSEIPESKPKDAKATEKHTDDDVVSSYDDPTELFHRDIGIQTSLPSSPNPQYAHHSQQKEAPTTHQSQRLARLTAALKLLNESVGDQTETLGDVHTVMDVLQQDVDKLNAAAATDFVGNFSMYGGPNKNEPDDEIKRAKENIRRVKGALLSTRSFPASSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWE3</accession>
    <name>Q2GWE3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225367.1">
        <property type="nucleotide sequence ID" value="XM_001225366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWE3"/>
    <dbReference type="GeneID" id="4393254"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07711"/>
    <dbReference type="HOGENOM" id="CLU_2454525_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWE3"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="89" mass="9828" checksum="78DFAFDCF29BE71C" modified="2006-03-21" version="1">MKLKRATTSNTTTTRPPQRQQQQQQQQFCQDGGCSPFHGLSSVHDQASQRVFGITQHPELLQTMKISGWAAFRAPDPGARGGTSMATVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWF8</accession>
    <name>Q2GWF8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_07696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225352.1">
        <property type="nucleotide sequence ID" value="XM_001225351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWF8"/>
    <dbReference type="FunCoup" id="Q2GWF8">
        <property type="interactions" value="771"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GWF8"/>
    <dbReference type="GeneID" id="4393593"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07696"/>
    <dbReference type="eggNOG" id="KOG3373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097408_1_2_1"/>
    <dbReference type="InParanoid" id="Q2GWF8"/>
    <dbReference type="OMA" id="YEEFTAV"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ86443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14505" checksum="C3ACD3386AA84AC0" modified="2006-03-21" version="1">MASITRCLRVARPAAFSAVARNSVPRTIGARAFSVTASNAIKRYTKEHEWIDISADKKTGVLGISEYAAKQLGDIVYVELPEEGKDVKVAEDDSHGGGWIAKVQLTEQGVEDFEKMMDVAAYEEFTAVEEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWI1</accession>
    <name>Q2GWI1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_07673</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225329.1">
        <property type="nucleotide sequence ID" value="XM_001225328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWI1"/>
    <dbReference type="GeneID" id="4393909"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07673"/>
    <dbReference type="eggNOG" id="ENOG502SMUF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_758622_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWI1"/>
    <dbReference type="OMA" id="ILLAWPC"/>
    <dbReference type="OrthoDB" id="5401779at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="53"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="265"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ86420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="365" mass="39011" checksum="BF5D42CE62F153CE" modified="2006-03-21" version="1">MSVPAGPDPTAMVGLMPAPLGVTPDFYHTTPVQVAFMAVFGVTYTLATIALILRLYTRVFVVKSVGFDEPLLIAAWAVTLAFFVVSVNAMPAGFGRNMYEVTQTQLVGYLEQLLLLALTYIWPPTLTKLSILVLYWRISPDRIFRVCIVATAVVLIAYTATFTGLFCGPCNPLLGTPESAVCLNNIAVSQAVLNIVTDGVIIVLPIPTIHRLNMGPEAAHHRRPHPRPRISVRVNPVPPTFPFPPTPIPTLQPASTNSPHAALGIASIVRVAYVRAMVANPDVTFTQCSAAVWSLLEMNLGILCNALAALKPFVRQHMPNLFSSNGWGSGGGAGGADGKPQRGVVVVPRPSAARSRAWGAYLSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX02</accession>
    <name>Q2GX02_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_07502</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225158.1">
        <property type="nucleotide sequence ID" value="XM_001225157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX02"/>
    <dbReference type="GeneID" id="4394410"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07502"/>
    <dbReference type="eggNOG" id="ENOG502SQ37">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_12_7_1"/>
    <dbReference type="InParanoid" id="Q2GX02"/>
    <dbReference type="OrthoDB" id="5278984at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="97"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ86249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="369" mass="41089" checksum="E05914728EFE548E" modified="2006-03-21" version="1">MEPPPDPPPGPAPMFPVNERIALLSQVHIGTTIPLLVLCLMPFFARMYIRIWPHSLPSASLDADIIHQLFAITDWALLEEELYFKPQLISFEETMFAVKLAYFAIPVWAIAMTLIKTSIILTLLRLPLKRSYKGMLYALLVIQLTFGTANTIYNFTKCQPFHASWDVTVKDRRCPSGETDLVVSNLMSALNIVTDLLLSVTPMFMFWNLHRPLRERILICSLTSIGLFATFASIMKVVVIAEWTTARDPWATAISIGTWTITEQFVSILAACSPSLKKPIENLLNKFGIPLVEHDPNISFMHIPPDMGSGASRRLARRRLDDGEAQLSPVPSHTATAETSRDRDAEGCGDKSLTCSVTGSTSRTALWGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXL2</accession>
    <name>Q2GXL2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CASP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_07292</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CASP family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224948.1">
        <property type="nucleotide sequence ID" value="XM_001224947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXL2"/>
    <dbReference type="FunCoup" id="Q2GXL2">
        <property type="interactions" value="213"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GXL2"/>
    <dbReference type="GeneID" id="4394272"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07292"/>
    <dbReference type="eggNOG" id="KOG0963">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016758_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GXL2"/>
    <dbReference type="OMA" id="KNARYSC"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012955">
        <property type="entry name" value="CASP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08172">
        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cux N-terminal" evidence="13">
        <location>
            <begin position="26"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="CASP C-terminal" evidence="12">
        <location>
            <begin position="488"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="501"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="565"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="152"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="265"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="423"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="572"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ86039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="688" mass="77471" checksum="C011EA4DF84D204B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXS1</accession>
    <name>Q2GXS1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="3">3.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3-hydroxyisobutyryl-coenzyme A hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CHGG_07233</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224889.1">
        <property type="nucleotide sequence ID" value="XM_001224888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXS1"/>
    <dbReference type="FunCoup" id="Q2GXS1">
        <property type="interactions" value="606"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GXS1"/>
    <dbReference type="GeneID" id="4393937"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07233"/>
    <dbReference type="eggNOG" id="KOG1684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_22_0_1"/>
    <dbReference type="InParanoid" id="Q2GXS1"/>
    <dbReference type="OMA" id="EVFTMEY"/>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000026">
        <property type="entry name" value="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="7">
        <location>
            <begin position="47"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAQ85980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="476" mass="53403" checksum="5E1800775BD4971F" modified="2006-03-21" version="1">MPLRAKLLSQQPQSQRLMSTQQAYDLFKPRDDDEPEDVLFNSLYGLRSVELNRPKKYNALNGSMIRKIAPRMLEWAKSDMANVIVMKGAGEKAFCAGGDVAQLAEWNQSGPEGQAKSKEYFAQEYQLDHLIATYNKPYVAFMDGITMGGGVGLSIHAPFRIATERTVFAMPETNIGFFPDVGGSFFLPRMPGSVGTYLALTSSRLTGANVFYSGVATHYLHSTSLPRLESRLAELRFNDEEDMETRLATINATIEEFVTGLPHDEPILLGGELRRAIDRCFCHNSVDQILSSLKRETGATRQWAEETITTLHARSPTAVHVALRQMRIGVKWSIRDTFIREHSIASKFMASHDFTEGVTALLVDKRPATWKPASLTEISPEQSPKLTEDYFLMSRKEPKLELLTEANYEDYPYAQFGVPTEAQVEKKVSLGTMSRPQIVDAFLRERSQKQGVKEVVEEILARKTTGGSRAVAKWVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GY62</accession>
    <name>Q2GY62_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224748.1">
        <property type="nucleotide sequence ID" value="XM_001224747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GY62"/>
    <dbReference type="GeneID" id="4393881"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07092"/>
    <dbReference type="eggNOG" id="ENOG502S8NN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101051_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GY62"/>
    <dbReference type="OMA" id="WGKIRGM"/>
    <dbReference type="OrthoDB" id="5424462at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF2">
        <property type="entry name" value="DUF3602 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="162" mass="16565" checksum="B475C3BA72674F31" modified="2006-03-21" version="1">MPSLYTITEPHPTVPQDSYTHSGRGGLGNFFRAPATTSPSGVPTPSHTTKTTSNNSSNTPRRFYSGRGGAGNAHQAHTSAATPSFDEEFALRESALTTVVGHVGRGGAGNVFSSSGSKGGATDGGVMLSRRDSASTEGSARSEASSSSSLAGFWGRVKSKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZF2</accession>
    <name>Q2GZF2_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224308.1">
        <property type="nucleotide sequence ID" value="XM_001224307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZF2"/>
    <dbReference type="STRING" id="306901.Q2GZF2"/>
    <dbReference type="GeneID" id="4391962"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05094"/>
    <dbReference type="HOGENOM" id="CLU_1343092_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZF2"/>
    <dbReference type="OrthoDB" id="3543857at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="204" mass="22658" checksum="79DD6AA1DE5C7010" modified="2006-03-21" version="1">MTGTMIAQHDTPSSSTSSVAAGSADSTMPYLTSPDTARTSPDTARTSPDTASASPDTSSIGPYVPGSIPLPKISLLPPENGKTGQIADKILMPRQLPHLPPGHTQTVPMYNISYPDRPGKRELVPFNEILQHVSLRELERWEDQCPHLRKEQKQQKAKARRQELRKQRQKEKEEGPKTRMVTRATRKRTGEVLLDKLNPSVGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZN8</accession>
    <name>Q2GZN8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_05008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224222.1">
        <property type="nucleotide sequence ID" value="XM_001224221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZN8"/>
    <dbReference type="GeneID" id="4391582"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05008"/>
    <dbReference type="HOGENOM" id="CLU_1503279_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZN8"/>
    <dbReference type="OrthoDB" id="10308505at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ88389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="179" mass="19332" checksum="21706BD01F478836" modified="2006-03-21" version="1">MLEAPVPLARSPWRDTGFSFCCVMEKDCAVDSAEHWGGVRLCMKPKSSVAAEVTSFQAQVETNAKIVSVCLNLCSCGASVSGKLLTSCQFRHGETEKRETHDPEPHPAEARVTALSPFPTDHLHGCHTSAPTSLASLILYHSLLSAETLQVPGAQRKIESLKPRCFNPLMVGINDDDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZY4</accession>
    <name>Q2GZY4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_04912</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224126.1">
        <property type="nucleotide sequence ID" value="XM_001224125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZY4"/>
    <dbReference type="STRING" id="306901.Q2GZY4"/>
    <dbReference type="GeneID" id="4391558"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04912"/>
    <dbReference type="eggNOG" id="KOG4192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055491_7_0_1"/>
    <dbReference type="InParanoid" id="Q2GZY4"/>
    <dbReference type="OMA" id="AINISWV"/>
    <dbReference type="OrthoDB" id="2993351at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="68"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ88293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="213" mass="23398" checksum="4B90C46F16043226" modified="2006-03-21" version="1">MGCADDSKARSLEPRGQDVGIPPCPPLSAAINISWVRSNGDTYGTPYAAPPFSGDEPAPAGFEDGKTYHGSCHCGAVTTAVRVKGSLEDGTYDGRLMECNCSYCRTGGFVWIYPQSNQLAIQGRDNLSYYKFGNTIWRKLFCKTCGVYIGSEVNPDLTAEEIAALPEMYQQFRTNHINTQPLNLRLINGLDVKSLKPLRGDGWSKQDPPYVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H091</accession>
    <name>Q2H091_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_04805</name>
    </gene>
    <organism evidence="5 6">
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        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224019.1">
        <property type="nucleotide sequence ID" value="XM_001224018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H091"/>
    <dbReference type="STRING" id="306901.Q2H091"/>
    <dbReference type="GeneID" id="4392820"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04805"/>
    <dbReference type="eggNOG" id="KOG2208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012058_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H091"/>
    <dbReference type="OMA" id="MCFEMHG"/>
    <dbReference type="OrthoDB" id="271862at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22453">
        <property type="entry name" value="KH-I_MUG60_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056553">
        <property type="entry name" value="KH_Mug60-KHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF76">
        <property type="entry name" value="KH DOMAIN-CONTAINING PROTEIN YLL032C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24563">
        <property type="entry name" value="KH_Mug60-KHD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="221"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="321"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="458"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="528"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ88186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="954" mass="106132" checksum="20C1F370E3078154" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0E3</accession>
    <name>Q2H0E3_CHAGB</name>
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        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">CHGG_04753</name>
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    <organism evidence="5 6">
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        <lineage>
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            <taxon>Sordariomycetes</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EAQ88134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001223966.1"/>
    </dbReference>
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    <dbReference type="STRING" id="306901.Q2H0E3"/>
    <dbReference type="GeneID" id="4392078"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04753"/>
    <dbReference type="eggNOG" id="KOG0730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_12_3_1"/>
    <dbReference type="InParanoid" id="Q2H0E3"/>
    <dbReference type="OMA" id="KPPTIHW"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001721">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="245"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="530"/>
            <end position="679"/>
        </location>
    </feature>
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        <location>
            <begin position="436"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ88134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="779" mass="86235" checksum="7460093586FDB275" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0K7</accession>
    <name>Q2H0K7_CHAGB</name>
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        <recommendedName>
            <fullName evidence="8">DUF1014 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">CHGG_04689</name>
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        <name type="common">Soil fungus</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC124 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EAQ88070.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001223902.1"/>
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    <dbReference type="STRING" id="306901.Q2H0K7"/>
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    <dbReference type="HOGENOM" id="CLU_069723_1_1_1"/>
    <dbReference type="InParanoid" id="Q2H0K7"/>
    <dbReference type="OMA" id="FEERMMP"/>
    <dbReference type="OrthoDB" id="76412at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010422">
        <property type="entry name" value="Ccdc124/Oxs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054414">
        <property type="entry name" value="Ccdc124/Oxs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054413">
        <property type="entry name" value="LSO1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06244">
        <property type="entry name" value="Ccdc124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22048">
        <property type="entry name" value="LSO1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LSO1/LSO2" evidence="5">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Coiled-coil" evidence="4">
        <location>
            <begin position="114"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ88070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="24347" checksum="8BFE59701E8F372C" modified="2006-03-21" version="1">MARKGGAEGNSKKAAGQARKAETAAKKAALAEAEKEASESAKWDKGAKSNSKKEAEAEKKAEQARKKAEREALLAEEEKNTPGRSAPKNSKAAVRKTRGLDLSQLDDDGSGGLSALNASGIDNALDALSLTSRTDAKIDRHPERRYKAAYAIFEERRLGEMDADGSGAGLRMNQKKERIKKEFERSPDNPFNQLTARYDTTKEELAQLKEQEKSKIETRLASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0N7</accession>
    <name>Q2H0N7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Isopropylmalate dehydrogenase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_04659</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223873.1">
        <property type="nucleotide sequence ID" value="XM_001223872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0N7"/>
    <dbReference type="STRING" id="306901.Q2H0N7"/>
    <dbReference type="GeneID" id="4391736"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04659"/>
    <dbReference type="eggNOG" id="KOG0786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_3_1"/>
    <dbReference type="InParanoid" id="Q2H0N7"/>
    <dbReference type="OMA" id="CRGVDMM"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF1">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="9">
        <location>
            <begin position="8"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ88040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="316" mass="33821" checksum="82C1F22B9E934087" modified="2006-03-21" version="1">MVTFVHSRQVIAEAIKVIRTVEELSPTAGKFNLEDHLIGGCSIDQTGVPLTDKALAAAKAAHAVLLGAVGGPEWGAGAVRPEQGLLKLRSEMCAYGNLRPCFFPSDALVESSPLKASVCRGTDMMLVRELTSGLYFGERKEYDGINAFDTAVYTKPEVERIARLGGYLARARGESRVISLDKANVLATSRLWRSVVDEVYKNEFPELKVEHQLIDSAAMIMVKNPTKLNGVLIAPNLAGSAPDISGKGIVNPIGTILSVAMMFRYSLDLAHEAKIVEDAVRAAIDAGLRTKDMGGNTTTAEAGDAIVAELVKILKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0Z6</accession>
    <name>Q2H0Z6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Carnitine O-acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="16">2.3.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CHGG_04550</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-carnitine + acetyl-CoA = O-acetyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:21136"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57589"/>
            <dbReference type="EC" id="2.3.1.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.7" evidence="16"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223764.1">
        <property type="nucleotide sequence ID" value="XM_001223763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0Z6"/>
    <dbReference type="FunCoup" id="Q2H0Z6">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H0Z6"/>
    <dbReference type="GeneID" id="4391990"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04550"/>
    <dbReference type="eggNOG" id="KOG3717">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013513_5_1_1"/>
    <dbReference type="InParanoid" id="Q2H0Z6"/>
    <dbReference type="OMA" id="ENHSKGP"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000007">
        <property type="entry name" value="Carnitine O-acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF103">
        <property type="entry name" value="CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 19" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="20">
        <location>
            <begin position="35"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EAQ87931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="611" mass="68974" checksum="85A27A0892A94B78" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H172</accession>
    <name>Q2H172_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_04474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223688.1">
        <property type="nucleotide sequence ID" value="XM_001223687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H172"/>
    <dbReference type="STRING" id="306901.Q2H172"/>
    <dbReference type="GeneID" id="4392406"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04474"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="InParanoid" id="Q2H172"/>
    <dbReference type="OMA" id="LQWESAK"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="354"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="49131" checksum="D3BF9C81FDB72612" modified="2006-03-21" version="1">MVFSSPAWVPDIPWLIPDSIPLGQFSLAGVNDGSDKGDSDVLLVDGLSGKSYSRADLHQRVECVAGGLAKEFGWSPDEGSPWDKVVAIYSLNTIDLFALSWAIHRLNGICLLLQPTSSVNEIVTHMRSAKCGAIFTCQTLISASVEAANCLSIPQTKIFTLPLPDGFLRNPEPTGNFKSLEDLAAIGAQTGPPPPLVWEKGQAKDQVAYLCATSGTSGRQLMLQSVQRYRIERLCLVRLTESVFTATLTGAHDTWAGSSGSLVPLTKARLVGPDGKEIESLNEAGEIFLSSPNLFKGYLGNEEATKESFDESGWLRTGDIGMFKKSPNGAEHLFILDRIKEMIKVKGLQVAPIEIELVLREHPAVADVAVIGVRDESAGERAKAFVVRSQSGKDDYDEDDLMDMLDDYVQERLDETHWLHDRIVFVEALPKSASGKVLKRELRALPLVAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H1E4</accession>
    <name>Q2H1E4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223616.1">
        <property type="nucleotide sequence ID" value="XM_001223615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H1E4"/>
    <dbReference type="GeneID" id="4392726"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04402"/>
    <dbReference type="eggNOG" id="ENOG502SNEG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037663_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H1E4"/>
    <dbReference type="OMA" id="QMAWDEL"/>
    <dbReference type="OrthoDB" id="4570054at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="75"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="400" mass="45870" checksum="AEFF91282B028918" modified="2006-03-21" version="1">MDEEQETEEVAFEHFKKHVDGLGRDVTLIHLAPDGCIISVSTDLINDVTECVYYPQLNLIQLSAGVRTILRSELRELDRFIGNVDLVSYQAESDDSKASVTKTAVFKYYWNSQFVGKIWDEMNLWLRLSHHPNIVPIDRLVLDEVQGGVVGFTTIFIPGGTLEDNVSRTFKLKWCKQLMALVDDLNLRYGIAHQDIVPRNLLVDESTDNIMLFDFDYSAQIGHGRGPLFLSYWYAKPSSSSSHLSTTNLEVRDIRDDVRAVVFTIYEMITRDFHFREEDWEKLDVSLIQDIEWVQHPDVTLDHPVAEYRSLLNAWLKTRAEGKKVTVYTDAPECIDWPILEMPIGEYTTSTGAVRQVQTWTPVDRSQALALGKKTVEWRRPKQSTLKGDYHLLATGELLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H201</accession>
    <name>Q2H201_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223409.1">
        <property type="nucleotide sequence ID" value="XM_001223408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H201"/>
    <dbReference type="GeneID" id="4392969"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04195"/>
    <dbReference type="HOGENOM" id="CLU_032734_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H201"/>
    <dbReference type="OrthoDB" id="5291055at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022025">
        <property type="entry name" value="Amidoligase_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12224">
        <property type="entry name" value="Amidoligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="600" mass="63490" checksum="575646047CA6B3E8" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2B7</accession>
    <name>Q2H2B7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_04079</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223293.1">
        <property type="nucleotide sequence ID" value="XM_001223292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2B7"/>
    <dbReference type="STRING" id="306901.Q2H2B7"/>
    <dbReference type="GeneID" id="4392317"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04079"/>
    <dbReference type="eggNOG" id="ENOG502ST51">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063299_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2B7"/>
    <dbReference type="OMA" id="AQKCNTA"/>
    <dbReference type="OrthoDB" id="5429716at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF33">
        <property type="entry name" value="MEMBRANE PROTEIN WSC4, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ87460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="379" mass="39905" checksum="C31A90CBD198D39E" modified="2006-03-21" version="1">MAFTDRERTILGPLTTVFTPPAPCTIAVGWCKTCDVAWWGQTCGGGGEEDNTSCWPTTTEGVPEPTKLPLYGWGFYSPGLECPAGYTSACSAVEGVTSQWKHQFRMEAEETFVGCCPEGFKCDNLRGQTCLMRAKSTELPTVSCENGASNNFGFTTLPNAAVTTMNLYAPMIQLAWKASDRPETSTLSSSATTSAPTTTTLNPTSAADPNAPTISEPALSTGAIVGIAIGAAALFLLTLAAAIFIWRRRRRHSHPGGVGPGNPLGNGSYAPSYSALRAGSPGMEDTKHYYTGGVMEMAPGHGRVEAPTEGHMRVEMGADRLVSPASPLVEAPGQDHGGGGPYAAHPRQVVIRGEGDMSPPPGYFQPPLGAVEMPVGRYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2G5</accession>
    <name>Q2H2G5_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223245.1">
        <property type="nucleotide sequence ID" value="XM_001223244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2G5"/>
    <dbReference type="GeneID" id="4392405"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04031"/>
    <dbReference type="HOGENOM" id="CLU_2527251_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2G5"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ87412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="84" mass="9154" checksum="19264CFE4C1DCB7F" modified="2006-03-21" version="1">MASNGWVSRPLRSGADPRSGQTCIGIQRHLELRAGDFALHLTVSFPGGVDCRLEVEGQKVDGGMLEVECSARIKIRGMWAWQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2H9</accession>
    <name>Q2H2H9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_04017</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223231.1">
        <property type="nucleotide sequence ID" value="XM_001223230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2H9"/>
    <dbReference type="GeneID" id="4391535"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04017"/>
    <dbReference type="eggNOG" id="KOG1225">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013427_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2H9"/>
    <dbReference type="OMA" id="ACRGDNT"/>
    <dbReference type="OrthoDB" id="10045365at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00053">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003431">
        <property type="entry name" value="B-propeller_Phytase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050969">
        <property type="entry name" value="Dev_Signal_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949:SF56">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7, 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02333">
        <property type="entry name" value="Phytase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50956">
        <property type="entry name" value="Thermostable phytase (3-phytase)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51662">
        <property type="entry name" value="BP_PHYTASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208433" description="EGF-like domain-containing protein" evidence="4">
        <location>
            <begin position="24"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="BPP" evidence="6">
        <location>
            <begin position="9"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="378"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="BPP" evidence="6">
        <location>
            <begin position="404"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ87398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="616" mass="65515" checksum="99BBA53D39E1D458" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2U9</accession>
    <name>Q2H2U9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223111.1">
        <property type="nucleotide sequence ID" value="XM_001223110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2U9"/>
    <dbReference type="GeneID" id="4391564"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03897"/>
    <dbReference type="eggNOG" id="ENOG502S2DU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021934_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H2U9"/>
    <dbReference type="OMA" id="YGFHASI"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF108">
        <property type="entry name" value="DAGKC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="87"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="407" mass="43379" checksum="78CF33A63E0F2720" modified="2006-03-21" version="1">MTTQHVNSAAGESLEDAITKIKREEVVFVVPKDSGSGYRIYSLVEGSTSDGEKPLNLEVVQCEQHQLPEDLSGFLLGQGRLPPAHLGPPREVHVVVSTHSGLKLAEDFYQGVLRSLLGAVGLESSEIKGQGGYQVTVTESSDTIRDFAQGLGRDGYATERTVILLSGDGGVTDFLNGQDRGPPPPDNALLPTIALLPLGTGNALFHSLHKPLYTTTTTTNPTPSPLSDTPAYRVHGAKRFAMAAGELLKLGHVYDVVVGVRRGGDGGGGGSEGESGEGVEGEGGEGGNGFNYILATLVSNLEKTFAISPKSRPLDGRLRLVHFGDVGGAKTMEIMMAAYREGEHVGMPEVGYEDVDEVKVTVAEEDPRWRKVCVDGSIVELERGGWVRVGREERERVKILVDAGVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H2V4</accession>
    <name>Q2H2V4_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_03892</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223106.1">
        <property type="nucleotide sequence ID" value="XM_001223105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H2V4"/>
    <dbReference type="GeneID" id="4391600"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03892"/>
    <dbReference type="eggNOG" id="KOG2262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004965_4_1_1"/>
    <dbReference type="InParanoid" id="Q2H2V4"/>
    <dbReference type="OMA" id="MTFDWAQ"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="465"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="532"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="606"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="707"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="734"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="764"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="816"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="888"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="963"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="650"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ87273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1027" mass="114332" checksum="0EF4900AB4E111D4" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H321</accession>
    <name>Q2H321_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ras-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_03825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223039.1">
        <property type="nucleotide sequence ID" value="XM_001223038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H321"/>
    <dbReference type="STRING" id="306901.Q2H321"/>
    <dbReference type="GeneID" id="4392503"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03825"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_9_8_1"/>
    <dbReference type="InParanoid" id="Q2H321"/>
    <dbReference type="OMA" id="RAVDIWG"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ87206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22297" checksum="3076E7493D1D6C16" modified="2006-03-21" version="1">MTQPLRVRSSKPPLPPLPPPQQLIDILVDSYRKQCMVDDEVALLDVLDTAGQEEYSAMREQYMRTGEGFLLVYSITSRESFEEIRTFQQQILRVKDKDVFPMVVVGNKLDLASERKVSVEEGKMLADEFNCSFLETSAKTNTNVEPAFFEVVRAIRNYNREMQGGPTIGGGLSHNGGGMGKMDMADDDAQAGCCSKCVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H373</accession>
    <name>Q2H373_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="9">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_03773</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="9"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ87154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222987.1">
        <property type="nucleotide sequence ID" value="XM_001222986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H373"/>
    <dbReference type="STRING" id="306901.Q2H373"/>
    <dbReference type="GeneID" id="4391838"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03773"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001613_7_0_1"/>
    <dbReference type="InParanoid" id="Q2H373"/>
    <dbReference type="OMA" id="CEIEYND"/>
    <dbReference type="OrthoDB" id="4580487at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="10">
        <location>
            <begin position="176"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="11">
        <location>
            <begin position="478"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ87154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="521" mass="58105" checksum="AF055798BE72CE0E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3M2</accession>
    <name>Q2H3M2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_06743</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222838.1">
        <property type="nucleotide sequence ID" value="XM_001222837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3M2"/>
    <dbReference type="FunCoup" id="Q2H3M2">
        <property type="interactions" value="235"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H3M2"/>
    <dbReference type="GeneID" id="4390766"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06743"/>
    <dbReference type="eggNOG" id="KOG0062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002848_0_1_1"/>
    <dbReference type="InParanoid" id="Q2H3M2"/>
    <dbReference type="OMA" id="EDHRKFG"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008079">
        <property type="term" value="F:translation termination factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000002">
        <property type="entry name" value="mRNA export factor elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="209"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="468"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="713"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1050"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1068"/>
            <end position="1077"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ90124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1113" mass="121973" checksum="0548FCE4DB995FA3" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3Q8</accession>
    <name>Q2H3Q8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gluconate 5-dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_06707</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222802.1">
        <property type="nucleotide sequence ID" value="XM_001222801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3Q8"/>
    <dbReference type="GeneID" id="4390814"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06707"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_12_0_1"/>
    <dbReference type="InParanoid" id="Q2H3Q8"/>
    <dbReference type="OMA" id="DQKSHIE"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ90088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="31977" checksum="CC4AE1F1D6B04667" modified="2006-03-21" version="1">MSKSVAVASHADFNRNSLFDLKGRVALVTGGGSGIGLMITQALAANGAKVYIVGRTREKLDKVVETYNKDIEGSIIALQGDVTKKDEVARLVKEVESREPCLCILVNNAGISSETVQPESGSATEMKQNLFDTSKSTTQDWLATYETDVVSLYFTTAAFLPLLQRSSERHPHWSGTVVNITSISGLIKTAQHHFAYNAAKGAAQHLTRMLAAEVAAAGHKVRVNGLAPGVFPSEMTAGESDEFQKSHIEKEKYEEKVPAGRPGRDIDMAQGVLGLVCNQYIDGHTLVVDGGYVLAAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H3T8</accession>
    <name>Q2H3T8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_06677</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ90058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222772.1">
        <property type="nucleotide sequence ID" value="XM_001222771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H3T8"/>
    <dbReference type="STRING" id="306901.Q2H3T8"/>
    <dbReference type="GeneID" id="4391459"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06677"/>
    <dbReference type="eggNOG" id="KOG2588">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053009_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H3T8"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208920" description="BHLH domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="242"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="204"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ90058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="390" mass="42029" checksum="352D8B479229E41E" modified="2006-03-21" version="1">MFVTYSCPLFLLSDLVPGAWWGARPVSRLALTMSKQSHPDVPPLTFFDTQDFGIDFPCDSAASSLSSFSPISSAGSSFGPPTTDAWAARDSLQHSQPEKLFEPPMFDLCPPPNANPSSVINPFGLTVPPSLKPPQVMLATIPGQQQPTTTAPSTSPIRPTTCPSASMAATRRYPFRRLKRKSTNDPCDSEPPPKSAAIPPPLNTSTRTRQSSTTSVTPRYKPVTPVTPVTPGTPDTPGTPDLKRTAHNAIEKRYRTNMNDRIAQLRNAVPELRRLAQQRSTVAKGTEGDEGDDRRAGLTGKLNKGIVLTKATQYILQLERKIQRLEADNRALRGRTEWLEASNGALKAQKEGLQMALMGGAAAVGDVGVGVGGVVSVMEEGWMQVLEGCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H4Z7</accession>
    <name>Q2H4Z7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_06268</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222363.1">
        <property type="nucleotide sequence ID" value="XM_001222362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H4Z7"/>
    <dbReference type="GeneID" id="4391317"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06268"/>
    <dbReference type="eggNOG" id="ENOG502RVY9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028617_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H4Z7"/>
    <dbReference type="OMA" id="YWSNETI"/>
    <dbReference type="OrthoDB" id="4696326at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208512" description="Fucose-specific lectin" evidence="3">
        <location>
            <begin position="21"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ89649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="50636" checksum="BA7844CD268C6B66" modified="2006-03-21" version="1">MAPLLSTLLLLGAAASPARASIAAWWTEVGPQIILQNTTTNQIRYSACNSRGQAKYSYTDASVFSLKYKPKVGTPVTGVGWYNKKETEASIWYITEQNTVANGLFICNDNTGRFEPQEEGNWVISPDTATIHSNTGLASVVLGQDTGYRVYYHDSDGAINELHYTRDTGWEHRGIISQDINSLPGLGVAFSGKGNITVAAPRDDQNIAVTRWNSDETWFRTTLPRPLDGGFVNGETIRADIALNETAETNFTLQAWDGKTKNIGVSIDNAYTRSLWYIGNDRNLYTVANQNYTWNKRASQSNAYWPQADEPNAELAVAYEFKSSMVRLYYTVNGQISEITYEDKTWKAWSALEAPPPPQATQSTTPSATNTAVASDTGLSTGAKAGIGVGVSLGVIALGAIIAVVVLARKRKQQALLQHPEDADEGSTTIGGDTPAPSYGSPALARASAAQYEQYGWDQKEAPTHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H562</accession>
    <name>Q2H562_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Myosin type II heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_06203</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Binds to cdc4 and rlc1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222298.1">
        <property type="nucleotide sequence ID" value="XM_001222297.1"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H562"/>
    <dbReference type="GeneID" id="4390387"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06203"/>
    <dbReference type="eggNOG" id="KOG0161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000192_5_3_1"/>
    <dbReference type="InParanoid" id="Q2H562"/>
    <dbReference type="OMA" id="DVRFLHK"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120104">
        <property type="term" value="C:mitotic actomyosin contractile ring, proximal layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902404">
        <property type="term" value="P:mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01377">
        <property type="entry name" value="MYSc_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000001">
        <property type="entry name" value="Myosin heavy chain, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.270.10">
        <property type="entry name" value="Myosin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055914">
        <property type="entry name" value="DUF7491"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24319">
        <property type="entry name" value="DUF7491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="13">
        <location>
            <begin position="61"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="12">
        <location>
            <begin position="115"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="9">
        <location>
            <begin position="688"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1556"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2167"/>
            <end position="2210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2294"/>
            <end position="2320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="860"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1630"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1816"/>
            <end position="1970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1557"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1581"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="2167"/>
            <end position="2202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="208"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ89584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2320" mass="265823" checksum="D63043BF6A99EC2E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H5V1</accession>
    <name>Q2H5V1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_05964</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the sal C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001222059.1">
        <property type="nucleotide sequence ID" value="XM_001222058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H5V1"/>
    <dbReference type="STRING" id="306901.Q2H5V1"/>
    <dbReference type="GeneID" id="4390809"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05964"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036835_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H5V1"/>
    <dbReference type="OMA" id="PMRSTFA"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000793">
        <property type="entry name" value="C2H2 finger domain protein FlbC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051565">
        <property type="entry name" value="Sal_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233:SF84">
        <property type="entry name" value="FI23031P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233">
        <property type="entry name" value="SAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ89345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="394" mass="42382" checksum="E7749BED210DF58E" modified="2006-03-21" version="1">MTMTMTDDHSRRRFGPLSNFHHMPSYSSQPHFSDPWSSYSPTGPAPQGGNQQHPIYAGNQESAGLPHLNIGSLPRQPPNSQHPQHPQHSATTGSSTSMAPYGSLPVTAGSAASAPISGVYRQHEMLSMPQDAFGLNRLQQPTSSAAYDASAYTSSASPVTASYPPASASPYEQLGYAPAQMRGTFAIGQEDNARRYSQQPLQTDDRRTFQDALEASQGMLSMSQDTPRNIYDVRNRARGSADSYGFPSTHSSTSSISSAGFSGYYGGSVDGSVSDYSAAGSDIESLSGRTLPRPQGLMSSQPPAPQSMMGSFSSRVSSSAQKKHKCKVCDKRFTRPSSLQTHMYSHTGEKPFGCEVEGCGRRFSVVSNLRRHKKVHKRGGETPSDTGSETHESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H686</accession>
    <name>Q2H686_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_05829</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
            <topology evidence="1 8">Peripheral membrane protein</topology>
            <orientation evidence="1 8">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221924.1">
        <property type="nucleotide sequence ID" value="XM_001221923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H686"/>
    <dbReference type="FunCoup" id="Q2H686">
        <property type="interactions" value="444"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H686"/>
    <dbReference type="GeneID" id="4390053"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05829"/>
    <dbReference type="eggNOG" id="KOG3489">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141397_1_0_1"/>
    <dbReference type="InParanoid" id="Q2H686"/>
    <dbReference type="OMA" id="NEICWDK"/>
    <dbReference type="OrthoDB" id="344165at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="9">
        <location>
            <begin position="26"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ89210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="96" mass="11020" checksum="DCFFD8542515703B" modified="2006-03-21" version="1">MSSTDFTIDQSDIEKLNDKDKTELRQFFANEEHRSRIQSQTHELTGICWKKCVTSGTFRSGALDKSEQSCLANCVDRFMDANLATMKHLASMRQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6A0</accession>
    <name>Q2H6A0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_05815</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221910.1">
        <property type="nucleotide sequence ID" value="XM_001221909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6A0"/>
    <dbReference type="STRING" id="306901.Q2H6A0"/>
    <dbReference type="GeneID" id="4391291"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05815"/>
    <dbReference type="eggNOG" id="KOG2190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022670_4_2_1"/>
    <dbReference type="InParanoid" id="Q2H6A0"/>
    <dbReference type="OMA" id="SIAKEPH"/>
    <dbReference type="OrthoDB" id="1937934at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070935">
        <property type="term" value="P:3'-UTR-mediated mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903138">
        <property type="term" value="P:negative regulation of cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903753">
        <property type="term" value="P:negative regulation of p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22455">
        <property type="entry name" value="KH-I_Rnc1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22456">
        <property type="entry name" value="KH-I_Rnc1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22457">
        <property type="entry name" value="KH-I_Rnc1_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049786">
        <property type="entry name" value="Rnc1_KH-I_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="48"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="134"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="289"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="227"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ89196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="375" mass="39944" checksum="F9EF334CB1E32483" modified="2006-03-21" version="1">MSAPQDAIPPNGSDLPEALDQLNLNDNEPRLGPDGEPAPKTDEEYAQTQLTLRAIVSSKEAGVIIGKGGKNVADLRDETGVKAGVSKVVQGVYDRVLTITGGCEAISRAYAVVARALLEGAPTIGMGGVVQSNGTHPIKLLISHNQMGTIIGRQGLKIKHIQDVSGVRMVAQKEMLPQSTERIVEVQGTPEGIQRAIWEICKCLVDDWQRGAGTVLYNPVVRTQGAGAAPGVTGTTNFVQDRAPYGGSRVTRTGNGADFSNGGPRPYNRRSDSDAAARGPPTHDENGEEIQTQNISIPADMVGCIIGRGGSKISEIRKTSGARISIAKAPHDETGERMFTIMGSAKANERALFLLYENLEAEKMRRQQQAAQTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6C7</accession>
    <name>Q2H6C7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial import inner membrane translocase subunit TIM14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit tim14</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 13">Presequence translocated-associated motor subunit PAM18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_05788</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TIM14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221883.1">
        <property type="nucleotide sequence ID" value="XM_001221882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6C7"/>
    <dbReference type="STRING" id="306901.Q2H6C7"/>
    <dbReference type="GeneID" id="4390170"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05788"/>
    <dbReference type="eggNOG" id="KOG0723">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_13_3_1"/>
    <dbReference type="InParanoid" id="Q2H6C7"/>
    <dbReference type="OMA" id="EPRMNKR"/>
    <dbReference type="OrthoDB" id="240298at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000001">
        <property type="entry name" value="Import inner membrane translocase subunit tim14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763:SF28">
        <property type="entry name" value="GEO10507P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ89169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="105" mass="11182" checksum="D4D4BDBB251232BC" modified="2006-03-21" version="1">MASAVAIGAGVAVAAFLGRAGLVAWRRSRGGVGALGKAFYKGGFEPRMNKREAALILSLNESGISKDKVRKAHRTLMLLNHPDRGGSPYLATKVNEAKEFLEKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6D3</accession>
    <name>Q2H6D3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221877.1">
        <property type="nucleotide sequence ID" value="XM_001221876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6D3"/>
    <dbReference type="GeneID" id="4390130"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05782"/>
    <dbReference type="eggNOG" id="ENOG502RITC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107714_2_2_1"/>
    <dbReference type="InParanoid" id="Q2H6D3"/>
    <dbReference type="OMA" id="CECMLFG"/>
    <dbReference type="OrthoDB" id="3468019at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39401">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39401:SF1">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ89163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20953" checksum="DE5B050468B94B8D" modified="2006-03-21" version="1">MAMAANDTTQQALDALTKRDMSSNSNLASGSQAIPGGESGYEPLYPNNIPTDSAVKSFITHFFEVSDDPGRNDEWVGFFDENATVIIGNDVAKGKEEIRKLRERMWKEVKARKHRLVKVFPASFSNDRSAIVLMNQAEYMLFGAVAYRMRDDAKEDAVAGWAGHAQLLRDGVAAPWRLGFYRVYIQR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-24" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6G4</accession>
    <name>EIF3A_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Eukaryotic translation initiation factor 3 subunit A</fullName>
            <shortName evidence="1">eIF3a</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Eukaryotic translation initiation factor 3 110 kDa subunit homolog</fullName>
            <shortName evidence="1">eIF3 p110</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Translation initiation factor eIF3, p110 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TIF32</name>
        <name type="ORF">CHGG_05751</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-3 subunit A family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221846.1">
        <property type="nucleotide sequence ID" value="XM_001221845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6G4"/>
    <dbReference type="SMR" id="Q2H6G4"/>
    <dbReference type="FunCoup" id="Q2H6G4">
        <property type="interactions" value="1161"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2H6G4"/>
    <dbReference type="GeneID" id="4391313"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05751"/>
    <dbReference type="eggNOG" id="KOG2072">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002096_2_1_1"/>
    <dbReference type="InParanoid" id="Q2H6G4"/>
    <dbReference type="OMA" id="EHITNKR"/>
    <dbReference type="OrthoDB" id="18884at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.860:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03000">
        <property type="entry name" value="eIF3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027512">
        <property type="entry name" value="EIF3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054711">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22591">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000366358" description="Eukaryotic translation initiation factor 3 subunit A">
        <location>
            <begin position="1"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="339"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="828"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="609"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="789"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="828"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="950"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1000"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="1061" mass="120569" checksum="3E819869C28CE223" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H6Q8</accession>
    <name>Q2H6Q8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucanase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_05657</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ89038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221752.1">
        <property type="nucleotide sequence ID" value="XM_001221751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H6Q8"/>
    <dbReference type="STRING" id="306901.Q2H6Q8"/>
    <dbReference type="GeneID" id="4391247"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05657"/>
    <dbReference type="eggNOG" id="ENOG502QPHV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020817_3_2_1"/>
    <dbReference type="InParanoid" id="Q2H6Q8"/>
    <dbReference type="OMA" id="CDASCTR"/>
    <dbReference type="OrthoDB" id="4563100at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209005" description="Glucanase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ89038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="435" mass="47867" checksum="F1D2C36C49201F15" modified="2006-03-21" version="1">MHWSLLTSPLALGLAAAQQVGKYENEIHPTLQWSSCGADGSCKKVDGGVTIDADFRWLHRVDNPGSCFDGNTWNDRGCDSVDNCTANCALEGADYVRSYGVKTSADTLSQRFRTNFDFAYNVGSRLFLMESQHRYQTFTLRDNELAFDVDLSTVECGINSALYFVSMDADGGMARYPTNAAGAEYGTGYCDASCTRSVKFVGGKANREGWIPSETDEFSGKGNLGSCCPQFSVWNSNAHSFSMSSHVCVKDGPHVCSAGDCLYNEPYAERGPGRCDATGCSYNPYRMGNKEFYGKGKTVDTAQKFTVVTQFTATKVTQFLVQNNTRFDIPAPTFTDLPREAGLSRDMCVKQFDLFAERDIMSELGGWEHHQSQLLDQPLVMVMSIGADVSTPPFLPFDGLGVYGALVEYQVWADRVDGQSLTVHLNILHAFIMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H7J7</accession>
    <name>Q2H7J7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_05368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408031">
        <property type="protein sequence ID" value="EAQ88749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221463.1">
        <property type="nucleotide sequence ID" value="XM_001221462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H7J7"/>
    <dbReference type="GeneID" id="4390421"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05368"/>
    <dbReference type="HOGENOM" id="CLU_1294246_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H7J7"/>
    <dbReference type="OrthoDB" id="10313400at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ88749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="213" mass="23158" checksum="E7DECE827141B489" modified="2006-03-21" version="1">MTSSSITSLSARGGLLLTRIPNNPVEDRGMNRPAIQVSTFTDLAGRESPGRAAGRLTFADALCIDPRSSESQKHPEEARFDNKNRHLRSNGDYLLAGNTSTEAWLLEDALTVRQKSAAGPETRFRHLHVACSPRSSDKKALATKVTIPALVFAQNPIHPRAALRSEVTESSQVLSTPSPSPRFPRHLFRRWSRCTANPQTAHATGQAGGLSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H892</accession>
    <name>Q2H892_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230078.1">
        <property type="nucleotide sequence ID" value="XM_001230077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H892"/>
    <dbReference type="GeneID" id="4388764"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03562"/>
    <dbReference type="eggNOG" id="ENOG502RKN7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2009499_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H892"/>
    <dbReference type="OMA" id="KDAWVAT"/>
    <dbReference type="OrthoDB" id="4590409at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="145" mass="16027" checksum="0D35BB9C7B2E740E" modified="2006-03-21" version="1">MDRKQRKDAWVATLTEVMPLTALDYTAPQNYMMQAFGFPFAKKSYSDTKAAVEYLKARLARTFSLIPGFGGQMIHALDGELPSLVYSAKERDSNLDHFPDEVFGFQVLDATQYPWTFDDLSNLGAQHQATPATQPPSASPSSTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8D7</accession>
    <name>Q2H8D7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_03517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230033.1">
        <property type="nucleotide sequence ID" value="XM_001230032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8D7"/>
    <dbReference type="GeneID" id="4388644"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03517"/>
    <dbReference type="HOGENOM" id="CLU_921334_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8D7"/>
    <dbReference type="OrthoDB" id="10406093at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ91582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="302" mass="32948" checksum="36F4CD9B22D20297" modified="2006-03-21" version="1">MLAKGDSGRRGQGCSPFQFQHCAAGTGKRRPRHGGRPGSSVWLLAARQETSSAAGSSSSSNRKSQSNACKLQLPTPRPRAPPTRRVVKSTSRNHPRLPSLGDKDVLGLLIHAEIHIAEPEEVLSPRHERGKFVEAVTRPSHNLNIIQVHVQVVVIVHIDVSVKLQNASLVMQEERQAEVVDELVDPDRPDEPEPRRSKTSTLEEKEEGLPTVGSLPTSCVTPAVSPAALFMALRKIQVELASSEKLHVRHVNMSLWSTSSSLGYSMLLHSEQNRKVICSAGFLRSSETEAAGDDIVGRVDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8K0</accession>
    <name>Q2H8K0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_03454</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229970.1">
        <property type="nucleotide sequence ID" value="XM_001229969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8K0"/>
    <dbReference type="STRING" id="306901.Q2H8K0"/>
    <dbReference type="GeneID" id="4389813"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03454"/>
    <dbReference type="eggNOG" id="ENOG502SA7D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_343216_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8K0"/>
    <dbReference type="OrthoDB" id="10263401at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13376">
        <property type="entry name" value="OmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="409"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="796"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ91519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="825" mass="92363" checksum="9F609151B51BEC20" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H8L3</accession>
    <name>Q2H8L3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_03441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ91506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001229957.1">
        <property type="nucleotide sequence ID" value="XM_001229956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H8L3"/>
    <dbReference type="GeneID" id="4389473"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_03441"/>
    <dbReference type="HOGENOM" id="CLU_2812118_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H8L3"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ91506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="67" mass="7226" checksum="38AB2CD91B6D2C8D" modified="2006-03-21" version="1">MAVNAVLSMLKGCVLGGLNLRWNTQASLPRSQRLPNTRPLIGTLRFMSSAMHTSGTIVSAWLSLPVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBC6</accession>
    <name>Q2HBC6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_02478</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYG1 (TC 2.A.94) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228994.1">
        <property type="nucleotide sequence ID" value="XM_001228993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBC6"/>
    <dbReference type="FunCoup" id="Q2HBC6">
        <property type="interactions" value="465"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HBC6"/>
    <dbReference type="GeneID" id="4389562"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02478"/>
    <dbReference type="eggNOG" id="KOG1162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006116_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HBC6"/>
    <dbReference type="OMA" id="YANSFEN"/>
    <dbReference type="OrthoDB" id="9970435at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14447">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14475">
        <property type="entry name" value="SPX_SYG1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF103">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 53 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="589"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="677"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="706"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="785"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="9">
        <location>
            <begin position="129"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="8">
        <location>
            <begin position="665"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="175"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="394"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="864"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="971"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="425"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="864"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="972"/>
            <end position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ90543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="990" mass="110308" checksum="BBACE064CD04AE42" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HBZ1</accession>
    <name>Q2HBZ1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_02263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408030">
        <property type="protein sequence ID" value="EAQ90328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228779.1">
        <property type="nucleotide sequence ID" value="XM_001228778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HBZ1"/>
    <dbReference type="STRING" id="306901.Q2HBZ1"/>
    <dbReference type="GeneID" id="4388705"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_02263"/>
    <dbReference type="eggNOG" id="KOG0272">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_6_16_1"/>
    <dbReference type="InParanoid" id="Q2HBZ1"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="97"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ90328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1261" mass="139872" checksum="2565C6F7C3A23B25" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HD77</accession>
    <name>Q2HD77_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CHGG_01827</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="EAQ93592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001221048.1">
        <property type="nucleotide sequence ID" value="XM_001221047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HD77"/>
    <dbReference type="FunCoup" id="Q2HD77">
        <property type="interactions" value="386"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HD77"/>
    <dbReference type="GeneID" id="4386959"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01827"/>
    <dbReference type="eggNOG" id="KOG0064">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007587_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HD77"/>
    <dbReference type="OMA" id="IHDMYLD"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="175"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="529"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="862"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="749"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="885"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="918"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ93592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="929" mass="102816" checksum="5DB8CA5601E29E0E" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDH0</accession>
    <name>Q2HDH0_CHAGB</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001220954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDH0"/>
    <dbReference type="GeneID" id="4386754"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01734"/>
    <dbReference type="HOGENOM" id="CLU_1981399_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HDH0"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="126" mass="13422" checksum="BF267202160BDE50" modified="2006-03-21" version="1">MSLPPMPQILQPSPALFKFSRPMPIPGLLVGGAVYGRAGDTHAGASHVRLQTASSSSARSRYAGAGRPSRRLSALRVEPTGFRLNQQERSNGGYLTIGSSRMVAQTKGFFPCPPPWRVGRVCGSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDK1</accession>
    <name>Q2HDK1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7624 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220924.1">
        <property type="nucleotide sequence ID" value="XM_001220923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDK1"/>
    <dbReference type="STRING" id="306901.Q2HDK1"/>
    <dbReference type="GeneID" id="4387513"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01703"/>
    <dbReference type="eggNOG" id="ENOG502SKIF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014596_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HDK1"/>
    <dbReference type="OMA" id="REGWTQV"/>
    <dbReference type="OrthoDB" id="5230484at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056041">
        <property type="entry name" value="DUF7624"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24616">
        <property type="entry name" value="DUF7624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7624" evidence="2">
        <location>
            <begin position="495"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="632" mass="69786" checksum="C7F566AFB757DC1C" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDM8</accession>
    <name>Q2HDM8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Eukaryotic translation initiation factor 4E-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_01676</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to interact with other partners.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220897.1">
        <property type="nucleotide sequence ID" value="XM_001220896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDM8"/>
    <dbReference type="FunCoup" id="Q2HDM8">
        <property type="interactions" value="1109"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HDM8"/>
    <dbReference type="GeneID" id="4387888"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01676"/>
    <dbReference type="eggNOG" id="KOG1670">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043552_2_2_1"/>
    <dbReference type="InParanoid" id="Q2HDM8"/>
    <dbReference type="OMA" id="QTEFKMM"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000004">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ93441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="28040" checksum="8F6992506652010D" modified="2006-03-21" version="1">MAEQVDLTTIPISPDGGNNPEAAAKEAAEDNDKTVTVFHDKDNFNVKHPLTNRWTLWFTKPASGKGDNWNDLLKEVITFESVEEFWGVYNNISAVSDLALKSDYHLFKEGVRPEWEDPQNKHGGKWSFQFKEKRTVNIDELWLHTMLGAIGETLEDEEDGEVMGVVVNVRKAFYRIGVWTRTTGRHIPGRGDGDIAGGKGRSSEKGKEILMSIGRRFKAVLKLPANEVIEFSGHTDSAHSGSTRAKAKMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDP0</accession>
    <name>Q2HDP0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7492 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_01664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220885.1">
        <property type="nucleotide sequence ID" value="XM_001220884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDP0"/>
    <dbReference type="GeneID" id="4388037"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01664"/>
    <dbReference type="eggNOG" id="ENOG502SABV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019095_0_2_1"/>
    <dbReference type="InParanoid" id="Q2HDP0"/>
    <dbReference type="OrthoDB" id="64281at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055915">
        <property type="entry name" value="DUF7492"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24320">
        <property type="entry name" value="DUF7492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004209144" description="DUF7492 domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7492" evidence="2">
        <location>
            <begin position="23"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ93429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="286" mass="31223" checksum="0765ECCD706D9CA7" modified="2006-03-21" version="1">MKLTFLDRTVAVWLLAALSGTAIAHSWPEQTIRLAPNGKEIGKPGADRAHIETGTGDFLIPPNGGEKVIKPDHKIVRDTQGPLNDASYSDQFPMLSVAQGDFVAIKYRENGHVSRADKSNPEKPVNRGTVYLYGTNENDLSNVNLMDVHLKWTSDGKGGNGKGKLIATRNYDDGQCHEVLPSDGDFEGIVGYRKEFISKADSLLCQNDIQIPSDAPVGKVYTVIWVWDWSSMNEQGVAVPPAEYGADSVLTPGAIHRRGRLQVVEACDDSLGETAIFKSMLNAFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HDU0</accession>
    <name>Q2HDU0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_01614</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220835.1">
        <property type="nucleotide sequence ID" value="XM_001220834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HDU0"/>
    <dbReference type="FunCoup" id="Q2HDU0">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HDU0"/>
    <dbReference type="GeneID" id="4386526"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01614"/>
    <dbReference type="eggNOG" id="ENOG502QQ71">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027506_3_2_1"/>
    <dbReference type="InParanoid" id="Q2HDU0"/>
    <dbReference type="OMA" id="WYIMFGR"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000152">
        <property type="entry name" value="Cell wall glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208819" description="chitinase" evidence="14">
        <location>
            <begin position="25"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="15">
        <location>
            <begin position="5"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAQ93379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="418" mass="43151" checksum="1B7A4C8E939C966F" modified="2006-03-21" version="1">MWFTPGWKGIAATATVLLSRTALAQTWSSCNPLSTTCPANTALGMSINVDFTQGEVNSFVSGGGRPTYGSDGVSFTVAGRGDSPQLASIFYIMFGRVEVTMKAAPGAGIVSSLVLLSDTLDEIDMEWLGSDDSEVQTNYFSKGQTTDYNRGQFNPAANNQAEFITYTIDWTTDRIVWYVGGTVVRTLTFDEAAGQYPQTPMQVKFGAWAGGDPSNPPGTIEWARGPTDYSKGPFSMIVRSAVVTDYSTGKKYTYGDQSGTWQSIRSDGGEINGNVNGAGSVVVTASAPAATGSLSPTIPPGGIIGGTATDGSGGPVRTVGPIPDGWIMTSEGKIVPVGSSTIPPAGSFSLGPSASLSPGFGSDATFTTRVAPGGTATPGVGMVPADAPAANNAVTATGQGLMRVLAVVLAGYSFYYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HE06</accession>
    <name>Q2HE06_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_01548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220769.1">
        <property type="nucleotide sequence ID" value="XM_001220768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HE06"/>
    <dbReference type="GeneID" id="4388001"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01548"/>
    <dbReference type="HOGENOM" id="CLU_2573664_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HE06"/>
    <dbReference type="OrthoDB" id="10560856at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ93313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="81" mass="8591" checksum="5559609C2A8F2567" modified="2006-03-21" version="1">MQSFVELHIHLQTHALPLPIIPLASSDPAALPTALQAFQSSLTTARSACRWPVDAARELLPWCTVTSSNVVRDAGTAVGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HE31</accession>
    <name>Q2HE31_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DUS-like FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_01523</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220744.1">
        <property type="nucleotide sequence ID" value="XM_001220743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HE31"/>
    <dbReference type="STRING" id="306901.Q2HE31"/>
    <dbReference type="GeneID" id="4386211"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01523"/>
    <dbReference type="eggNOG" id="KOG2334">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_3_2_1"/>
    <dbReference type="InParanoid" id="Q2HE31"/>
    <dbReference type="OrthoDB" id="10262250at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052582">
        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="11">
        <location>
            <begin position="121"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="386"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="621"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="419"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="646"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ93288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="655" mass="70110" checksum="66E19CC54BEE9339" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HE92</accession>
    <name>Q2HE92_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_01462</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220683.1">
        <property type="nucleotide sequence ID" value="XM_001220682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HE92"/>
    <dbReference type="STRING" id="306901.Q2HE92"/>
    <dbReference type="GeneID" id="4387057"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01462"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_1"/>
    <dbReference type="InParanoid" id="Q2HE92"/>
    <dbReference type="OMA" id="GMGRNRP"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08243">
        <property type="entry name" value="quinone_oxidoreductase_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="25"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ93227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="356" mass="37896" checksum="EEA1BDECD93B5D7C" modified="2006-03-21" version="1">MSSSSNNNNHTEPTTMKAILITRPGPPSTLQIHTDLPLPQPTPGTVRIRIRAFGVNHAEMHMRRGEWAESVPISGIECVGTVDACPGGEFAVGEPVAAIMGGMGRTVPGSYAQFTVVRVGNVVALGNGAVEGDGGELSLPLSWAELAALPESYCTAWTCLFRNLALQRGQRLLIRGATSAFGRAASNLAVEAGAVVTGTTRSEAKFAELRALGVADVVLEGPGLPERLRESGRAGEKFDRVLELVGNSTVVESLTLVKRDGRVCLAGWLGGLDPIKDFNPLLQMASGVHLNFFGSFVFGNPEFPLSDVPLNSIVRAVADGKFDAKPFKVFRFDEIQEAHQYMEDGRAAGKMVVVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEK1</accession>
    <name>Q2HEK1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">homoisocitrate dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CHGG_01353</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2R,3S)-homoisocitrate + NAD(+) = 2-oxoadipate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:11900"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57499"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.87" evidence="12"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220574.1">
        <property type="nucleotide sequence ID" value="XM_001220573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEK1"/>
    <dbReference type="FunCoup" id="Q2HEK1">
        <property type="interactions" value="530"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HEK1"/>
    <dbReference type="GeneID" id="4386315"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01353"/>
    <dbReference type="eggNOG" id="KOG0785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HEK1"/>
    <dbReference type="OMA" id="DSFVMGE"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047046">
        <property type="term" value="F:homoisocitrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000012">
        <property type="entry name" value="Homoisocitrate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF48">
        <property type="entry name" value="HOMOISOCITRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="13">
        <location>
            <begin position="7"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAQ93118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="357" mass="37782" checksum="A2796FF976B75F6D" modified="2006-03-21" version="1">MATRTLRIGLIPGDGIGKEVIPAGRRLLEALPASLGLKFEFVDLEAGWETFEKQGVALPEKTVSVLKSECDGALFGAVSSPTTAVKGYSSPIVALRKKLDLYANVRPVKTVVSAPKPIDMVIVRENTEDLYVKEETTRDTAEGKVAEAIKRISQRASSRIATIAGEIALRRQKIRAGGSPSIHTGPLVTITHKSNVLSQTDGLFRSTAREALAAPAFAGRVAVEEQIVDSMVYKLFRQPEAYDVIVAPNLYGDILSDGAAALVGSLGLVPSANVGEGFAIGEPCHGSAPDIQGQGISNPIATLRSAALMLEFLNEEAAAAKIYAAVDGNLEDGKLLSPDLGGTAKTEEVVQDILRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEK3</accession>
    <name>Q2HEK3_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_01351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220572.1">
        <property type="nucleotide sequence ID" value="XM_001220571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEK3"/>
    <dbReference type="GeneID" id="4386313"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01351"/>
    <dbReference type="eggNOG" id="ENOG502SU0I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024239_2_0_1"/>
    <dbReference type="InParanoid" id="Q2HEK3"/>
    <dbReference type="OMA" id="NPHHPGV"/>
    <dbReference type="OrthoDB" id="3600083at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="478"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="525"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ93116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="538" mass="56200" checksum="A4D1BC30652C1ADE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HEQ8</accession>
    <name>Q2HEQ8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_01296</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ93061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220517.1">
        <property type="nucleotide sequence ID" value="XM_001220516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HEQ8"/>
    <dbReference type="GeneID" id="4388229"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01296"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009043_1_0_1"/>
    <dbReference type="InParanoid" id="Q2HEQ8"/>
    <dbReference type="OMA" id="IELCADN"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="256"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="334"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ93061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="703" mass="77319" checksum="9922D6D94D89177F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HF81</accession>
    <name>Q2HF81_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nucleotide-diphospho-sugar transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_01123</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220344.1">
        <property type="nucleotide sequence ID" value="XM_001220343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HF81"/>
    <dbReference type="STRING" id="306901.Q2HF81"/>
    <dbReference type="GeneID" id="4387633"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01123"/>
    <dbReference type="eggNOG" id="ENOG502QQ16">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013298_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HF81"/>
    <dbReference type="OrthoDB" id="4484309at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ92888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="43485" checksum="80C83A2D2E3EBDB2" modified="2006-03-21" version="1">MATSPTDTAVLPTPRCQAPMDQTVQGGGVAFLRHFTLRPRRVILRVDKWVGISVPTFERFQWKVLSILVSSFQNVLFLDADCLPILNPDTIFHQGSEPFTSAGLITWPDFWTSTASPLFYKVAGDIDIPPITSRATSESGILVYDKARHADTLLLAAYYNYNGPKHYYPLLSQHGAGEGDKETFLQAALVLEALRQKGVYQQPTAWMRSGAGVGVKKGYYDVKKPPVVHGRSARGKWTGMFLLQMDPMEDYRAVMAAINKVSKRDEAEAIVIEDFLTNSTFLDTLGDLKLEYHGHSMFFHHSGVKPDFTRILDEKWSLVKTDEAGRYVRMWGHIGWVIDTLGRDVEKLLWEDSMQVYCQEDLAQFKRLQDVCAKMRVIHDQLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HFB4</accession>
    <name>Q2HFB4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial</fullName>
            <ecNumber evidence="11">1.14.15.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-methoxy-6-polyprenolphenol 4-hydroxylase</fullName>
            <ecNumber evidence="11">1.14.15.46</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COQ6</name>
        <name evidence="13" type="ORF">CHGG_01090</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)phenol + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81183"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="EC" id="1.14.15.46"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81195"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="1.14.15.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.45" evidence="11"/>
    <dbReference type="EC" id="1.14.15.46" evidence="11"/>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220311.1">
        <property type="nucleotide sequence ID" value="XM_001220310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HFB4"/>
    <dbReference type="FunCoup" id="Q2HFB4">
        <property type="interactions" value="350"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HFB4"/>
    <dbReference type="GeneID" id="4387041"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_01090"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_8_0_1"/>
    <dbReference type="InParanoid" id="Q2HFB4"/>
    <dbReference type="OMA" id="VKQMQVW"/>
    <dbReference type="OrthoDB" id="683240at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120538">
        <property type="term" value="F:2-methoxy-6-polyprenolphenol 4-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106364">
        <property type="term" value="F:4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000021">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03193">
        <property type="entry name" value="COQ6_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000689">
        <property type="entry name" value="UbQ_mOase_COQ6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="3 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="328"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ92855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="472" mass="51357" checksum="09A8C7E902CA660A" modified="2006-03-21" version="1">MNTVIGRRSAYVCRSCTRSFQKQLRRTYASTSAQPDIYDVVCVGGGPAGLSLLTALRANPVTAHLRIALVEAQDLAKTRSWKLPANKFSNRCSSLTPSSVSFLDQIGAWSHLERDRVQAYQEMQVWDGVTGARIEFDWAQSSTPAAGTTIAYMNENLNLTSGLLKRIDELGGVSVFDKAKVERIAYGEETEEVDLREWPVIHLSAQCGRSLASKLAVGTTTVMASSPHLRWKGRDGGGDHLKTAYQRFLPTGPVAMLPLPGNYSTLVWSTTPANASRLKSLSAKDFIATVNAAFRLSPTDLEYMHTQESGQAEEYSWRLEHTPVDHRAIPQVAVGVQEGTVASFPLKLRHADTYIAERVALVGDAAHTIHPLAGQGLNQGQGDVQSLAKAIEYAVRHGQDIGVTMSLEPYASERYAANHLLLGVCDKLHKLYSVGSGPLVPLRSVGLNAVNALRPLKSFFMNQAAGNGIKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG33</accession>
    <name>Q2HG33_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_00821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220042.1">
        <property type="nucleotide sequence ID" value="XM_001220041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG33"/>
    <dbReference type="GeneID" id="4386251"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00821"/>
    <dbReference type="eggNOG" id="ENOG502S6BC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021798_0_1_1"/>
    <dbReference type="InParanoid" id="Q2HG33"/>
    <dbReference type="OMA" id="MLNRDCR"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00083">
        <property type="entry name" value="bHLH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46266">
        <property type="entry name" value="TRANSCRIPTION FACTOR TT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46266:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR TT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="143"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ92586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="385" mass="40682" checksum="DD5BA3A5551C9CA4" modified="2006-03-21" version="1">MPRNTFLPTPASSTDIKGQDGSKMASLQLAFELPPPAVTSEAGANHPNTSATFYPTQASETVKSRRRSSAANPPKDQFALPPPPTRSRKIIQMKPREEPTPETPASTSKTASKGNAGTSSTTQVAGSKRKQPSATSAAGRKIARKTAHSLIERRRRSKMNEEFAVLKGLIPACTGEMHKLAILQASIEYVRYLEDCVTKLKAQCGSEAMLDPEPRLSQSGLPSPSMGDTYNHGHGHNYAGGAVDPCSPDVEMTSSSSAPSPSFTPIAGRSQAPSISPALRPQDPSRHNSYSSVSSDYRLHGGSGGYSTSTTTSPFFGPQHGTATGVSSSHSAFGSALTSPALPPQRDLDQEATTALLMLNQMDRRTSTSTATAPRGMSVRDLLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG35</accession>
    <name>Q2HG35_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220040.1">
        <property type="nucleotide sequence ID" value="XM_001220039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG35"/>
    <dbReference type="GeneID" id="4386249"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00819"/>
    <dbReference type="HOGENOM" id="CLU_1209694_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HG35"/>
    <dbReference type="OrthoDB" id="10533939at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="229" mass="25118" checksum="D21E9D923479A9A1" modified="2006-03-21" version="1">MHPVHAAEQQTAHQPAHELPKSAPPGPESCINNVGQPPEDHSKTTTRQGADACLHAGDATGSGLLMLPETTQTTTPFPHPNLLPARDICTPMNNHCTNPCYAEDDAGSVLHTIHRCSAAHRSDGAAGAAQHAHAMPCMYPFGDSWCGCTHGLTGQHTAYERVLTYAGETVRVEGIWRTLGGQRRDRRAEWRGRARAVSNKRVVPIWTNEIESQLQNMVVIQNNMKRSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HG74</accession>
    <name>Q2HG74_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA splicing factor CLF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_00780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001220001.1">
        <property type="nucleotide sequence ID" value="XM_001220000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HG74"/>
    <dbReference type="STRING" id="306901.Q2HG74"/>
    <dbReference type="GeneID" id="4386879"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00780"/>
    <dbReference type="eggNOG" id="ENOG502SM8T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013054_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HG74"/>
    <dbReference type="OMA" id="FQDQGME"/>
    <dbReference type="OrthoDB" id="5352000at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ92545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="705" mass="74361" checksum="A3C263A8CE1B7E0B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGD6</accession>
    <name>Q2HGD6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_00718</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219939.1">
        <property type="nucleotide sequence ID" value="XM_001219938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGD6"/>
    <dbReference type="STRING" id="306901.Q2HGD6"/>
    <dbReference type="GeneID" id="4386759"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00718"/>
    <dbReference type="eggNOG" id="KOG1681">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_0_1"/>
    <dbReference type="InParanoid" id="Q2HGD6"/>
    <dbReference type="OMA" id="QYVAHVE"/>
    <dbReference type="OrthoDB" id="14970at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000004">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000024">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ92483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="287" mass="30478" checksum="3069EEA9B36687F0" modified="2006-03-21" version="1">MAQQQQPLAAYAHYQHYIVTAPSPLVAHVEINRPAKLNAFHEAMWLELRAVFRQLSADSDVRAVVLSGAGDRAFTAGLDVTAAREGGVLSGAEGLDGARTAARLRRYIAEFQECLSAVERCEKPVICVMHGVAIGLAIDLSCCADIRVCAKDARFAVKEVDIGLAADIGTLARLPKAVGSQSWVKDVCLTARGFDAAEALAVGFVSQVHDSKAAALAAAVKTAGFLASKSPVAVQGTKELLNHSRDHTVEDNLRYTGVWNAAALQTNDVAAALMSGLNKKKPTFEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HGR9</accession>
    <name>Q2HGR9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Multiprotein-bridging factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_00585</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219806.1">
        <property type="nucleotide sequence ID" value="XM_001219805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HGR9"/>
    <dbReference type="FunCoup" id="Q2HGR9">
        <property type="interactions" value="681"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2HGR9"/>
    <dbReference type="GeneID" id="4387213"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00585"/>
    <dbReference type="eggNOG" id="KOG3398">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112609_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HGR9"/>
    <dbReference type="OMA" id="GKNKSCK"/>
    <dbReference type="OrthoDB" id="10253401at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000030">
        <property type="entry name" value="Coactivator bridging factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="8">
        <location>
            <begin position="100"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ92350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="160" mass="17059" checksum="EF652410FF002F88" modified="2006-03-21" version="1">MSAWDTETVKIGKNVSRGGGAARETVVRGQSALNAARRTGAAITTEKKFATGNASSGVEGQRLTMVDRSDDIVKPKTVGVEVGKAIQKARAEFEQANGNKGLTQKELATKCNTTPTIVASFERGDATPDQKVLAAMERVLNVKLRGSDIGKPKFERKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHC4</accession>
    <name>Q2HHC4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rad54 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_00380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408029">
        <property type="protein sequence ID" value="EAQ92145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001219601.1">
        <property type="nucleotide sequence ID" value="XM_001219600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HHC4"/>
    <dbReference type="STRING" id="306901.Q2HHC4"/>
    <dbReference type="GeneID" id="4387946"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_00380"/>
    <dbReference type="eggNOG" id="KOG0390">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094268_0_0_1"/>
    <dbReference type="InParanoid" id="Q2HHC4"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013967">
        <property type="entry name" value="Rad54_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08658">
        <property type="entry name" value="Rad54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad54 N-terminal" evidence="5">
        <location>
            <begin position="63"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="189"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ92145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="258" mass="28508" checksum="C88AEA4D7EE85733" modified="2006-03-21" version="1">MVGWSHLPVGGNTYGNETLWMNIVVCKGQLNTRVNMTVSTSTTPATPAANKENLVSRSRFPTPQSLDRLHRPFKCPGSATRTVATDRPARKRRRVDYGGADGEADADKPYTNADRLALANRDANRFPVFKAKDKDTIFRKAFSVPFVNKDNAAYNPNRPPPTLGLRQGAVFVAKPLHDPCGEFAIVLHDPTVDDKPKETSTPEEKQKEAEAPPKLDAPLMHKSLAEILGIKKKVEGEHPRVPVVIDPRLAKVLRPHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HHD9</accession>
    <name>Q2HHD9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arginase</fullName>
            <ecNumber evidence="3">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_00365</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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                <person name="Birren B.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
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        </source>
    </evidence>
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</entry>
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                <person name="Untereiner W.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
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    <sequence length="689" mass="74315" checksum="2039345D5754D3BE" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="65" xmlns="https://uniprot.org/uniprot">
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        </source>
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        <subcellularLocation>
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        </subcellularLocation>
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        <property type="entry name" value="Znf_CCHC_sf"/>
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        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
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    </feature>
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        <location>
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    </feature>
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        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
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        <location>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50878"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1251" mass="139033" checksum="C3839B8498B55B1B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GLZ9</accession>
    <name>Q2GLZ9_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_11057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408038">
        <property type="protein sequence ID" value="EAQ82881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001230233.1">
        <property type="nucleotide sequence ID" value="XM_001230232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GLZ9"/>
    <dbReference type="STRING" id="306901.Q2GLZ9"/>
    <dbReference type="GeneID" id="4397364"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_11057"/>
    <dbReference type="eggNOG" id="ENOG502S3K9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103010_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GLZ9"/>
    <dbReference type="OMA" id="HLIHYLA"/>
    <dbReference type="OrthoDB" id="5336600at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF4">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ82881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="24346" checksum="5993F15A38AAEEF6" modified="2006-03-21" version="1">MPNPSPIVLILGAGSNVGHHVAQAFRNTGYRVALAARSVNESDNTDEQVYLPSDFSDPDSIVKVFSKLKSSLGVPSVVIYNASAGKANPVDNPLSVPLADFAQALNINTTSAFVAAQQAVLAFEQLPASASKTFIFTGNALNTTILAPLMLGGVGKSATAHIIQSAAAAYADKGYKFYYAGERKADGKPAYMDIDGAAHAEQYVALAEDKSQGPWHYTFVKGVGYKKFPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMH1</accession>
    <name>Q2GMH1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_10833</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226100.1">
        <property type="nucleotide sequence ID" value="XM_001226099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMH1"/>
    <dbReference type="GeneID" id="4397093"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10833"/>
    <dbReference type="eggNOG" id="ENOG502RF8N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015502_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GMH1"/>
    <dbReference type="OMA" id="CHKAMAN"/>
    <dbReference type="OrthoDB" id="2399539at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="533"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ83015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="593" mass="65709" checksum="2CB7356F6178C0C3" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMH2</accession>
    <name>Q2GMH2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_10832</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ83014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226099.1">
        <property type="nucleotide sequence ID" value="XM_001226098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMH2"/>
    <dbReference type="STRING" id="306901.Q2GMH2"/>
    <dbReference type="GeneID" id="4397092"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10832"/>
    <dbReference type="eggNOG" id="KOG2495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021377_8_0_1"/>
    <dbReference type="InParanoid" id="Q2GMH2"/>
    <dbReference type="OMA" id="VDPRSYM"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF45">
        <property type="entry name" value="NADH DEHYDROGENASE-LIKE PROTEIN RV1812C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="7"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ83014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="418" mass="44131" checksum="E538FDCE022F4ACD" modified="2006-03-21" version="1">MAGEQKRIVIIGAGFAGMWSALSARRAIVYNATERASNIDVVVIAPSDDLVVRPRLYEDGPENMKSSLTELFAATGVRFIKGTVDEINTESHEVSVLDPQGTRSSVTYDRLVVAAGSRLVRPKIDGLDEHAFSIDSIDEAVKLDNHLKSVANLPPSPARDTAVVCGGGFTGIEIAAELPARLRAILGPDTNVRVVVVDRNEHIGPELGPGPRPAITEAFKSLGVEMKLGSAVTAVDAEGVTLASGERIETFTAVWTGGVAANALTQQIAGEKDTFGRLHTDRTLRVPSEPHVYATGDTAHAATDDDGNCAMMSCQHANILGRSSGYNAAADLLGVPQVPYEQADYGTCLDLGPWGAVVTKGWEREVQLTGAEAKKVKKWVNGVLIYPPKADAEEALAAADPVYKIPDLADGPATGAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GMK3</accession>
    <name>Q2GMK3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_10801</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408036">
        <property type="protein sequence ID" value="EAQ82983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226068.1">
        <property type="nucleotide sequence ID" value="XM_001226067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GMK3"/>
    <dbReference type="STRING" id="306901.Q2GMK3"/>
    <dbReference type="GeneID" id="4397107"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10801"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_23_6_1"/>
    <dbReference type="InParanoid" id="Q2GMK3"/>
    <dbReference type="OMA" id="THETDHD"/>
    <dbReference type="OrthoDB" id="411871at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="4">
        <location>
            <begin position="241"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="652"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ82983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="851" mass="95453" checksum="AAC301ED341A0BED" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GN87</accession>
    <name>Q2GN87_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_10567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228494.1">
        <property type="nucleotide sequence ID" value="XM_001228493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GN87"/>
    <dbReference type="GeneID" id="4396446"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10567"/>
    <dbReference type="HOGENOM" id="CLU_906143_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GN87"/>
    <dbReference type="OrthoDB" id="4578474at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ84163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="307" mass="35102" checksum="32B0E170ADCCF6BE" modified="2006-03-21" version="1">MHPARTTFVALQPPSLPGAGEPETVIITVKPAEDEADPFAVIGFDITLTEDSELRIKPRRNRINLVLLSTKLMRRAAMEVDQCRALLGNRKRCQLRRNGRDWCPVHREYHQFLHNGELNDRKHLYEQLELHQLKPRTASLALRIMVTEILYAGDEDDNHGTFFHMTKQNRANLSQQLSWNRSDGSNRRPISTFIDDFLAAAREREGKPESRSVWADSAVVNLADVRTMQAFQTQSRYPSVSELFGAAGSLEMRNHLLEKARLNGDLPDLPPRPTPQAPVVVKPLTEEEEREYWVKRGAQCCIDTSDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GNL3</accession>
    <name>Q2GNL3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phenol 2-monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_10441</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ84037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228368.1">
        <property type="nucleotide sequence ID" value="XM_001228367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GNL3"/>
    <dbReference type="GeneID" id="4396992"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10441"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_9_3_1"/>
    <dbReference type="InParanoid" id="Q2GNL3"/>
    <dbReference type="OMA" id="IMAYEPA"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF7">
        <property type="entry name" value="P-HYDROXYBENZOATE-M-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="14"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="424"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ84037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="641" mass="71285" checksum="71F6E619B70820AD" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GP67</accession>
    <name>Q2GP67_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_10237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001228164.1">
        <property type="nucleotide sequence ID" value="XM_001228163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GP67"/>
    <dbReference type="GeneID" id="4396829"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_10237"/>
    <dbReference type="eggNOG" id="ENOG502RJ34">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1058392_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GP67"/>
    <dbReference type="OMA" id="TKVVCAI"/>
    <dbReference type="OrthoDB" id="5239281at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="219" mass="22210" checksum="BD68B463744ECD14" modified="2006-03-21" version="1">MPRPAKTAAAADAAGDGQPCASAGTINGVIPTANDIKFIFAFIGNLKSKPEVNWDELAATMGMGGKKSATERWRLMRQKFNITLAEEAEAPGSARKGGKKATTAKAATKTDNADDDDEYNDKETEPKSAPATPAKRGRKPAAASAAATPPSATPASAAGKKRAAASTAGEGSSPAASDEDMASPTKKAKSSTAMEVDSPLSPVPSMIADEDSGADMAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GPX2</accession>
    <name>Q2GPX2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227909.1">
        <property type="nucleotide sequence ID" value="XM_001227908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GPX2"/>
    <dbReference type="STRING" id="306901.Q2GPX2"/>
    <dbReference type="GeneID" id="4396554"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09982"/>
    <dbReference type="eggNOG" id="ENOG502RXTJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1283130_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GPX2"/>
    <dbReference type="OrthoDB" id="674948at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40129">
        <property type="entry name" value="KETOPANTOATE REDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40129:SF2">
        <property type="entry name" value="KETOPANTOATE REDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ83578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="22292" checksum="A34AB1106E7CFEA7" modified="2006-03-21" version="1">MEELTLLILGAGWTATFLIPLLESRNISFAATTTTGHPVAGAPTLTFKFDPSAPEDQTRAAIAALPRARHVLITFPLKGTGPSKLLLETYANTHRSAAAAEPNSSSPSPSPSPSPSPSTPRFIQLGQRGHLAARLALPTPTPPIPHPPTTPPSNRNPPLENPGTPPTPPTTRAPSPRTSCARSGGCVLVSGRAVGAARAPVRGWAGRVAGDEGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQ73</accession>
    <name>Q2GQ73_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Prefoldin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CHGG_09881</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227808.1">
        <property type="nucleotide sequence ID" value="XM_001227807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GQ73"/>
    <dbReference type="STRING" id="306901.Q2GQ73"/>
    <dbReference type="GeneID" id="4396881"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09881"/>
    <dbReference type="eggNOG" id="KOG3478">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1266735_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GQ73"/>
    <dbReference type="OrthoDB" id="248120at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
        <property type="entry name" value="Prefoldin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000003">
        <property type="entry name" value="Prefoldin subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAQ83477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24854" checksum="38172E806FB49CCE" modified="2006-03-21" version="1">MADTQAKLQALSEEFTKLQQDLQDTVQSRQKLEAQMQENLGVQKEFSKLKEGETIYKLIGPVLLKQEKAEAESTVNGRLEFIEKETVRRRKTKTMPATASTNRHDLSWSSSPAAMRNDFSVTKGADVVSKMEFRMRSRVAGSARMFEGSLRSKICFILLKHWVRRLNRHASDGMDNRPRVRLRKSMDDWMLATRVSRMMDSKATNISTLASEAPRVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GQQ7</accession>
    <name>Q2GQQ7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Structural maintenance of chromosomes protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CHGG_09697</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH408035">
        <property type="protein sequence ID" value="EAQ83293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227624.1">
        <property type="nucleotide sequence ID" value="XM_001227623.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q2GQQ7">
        <property type="interactions" value="747"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GQQ7"/>
    <dbReference type="GeneID" id="4396240"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09697"/>
    <dbReference type="eggNOG" id="KOG0996">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_4_1_1"/>
    <dbReference type="InParanoid" id="Q2GQQ7"/>
    <dbReference type="OMA" id="CPALDNM"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1620:FF:000003">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000481">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000585">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="762"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1143"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1492"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="553"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="641"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1143"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1219"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1506"/>
            <end position="1517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAQ83293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1690" mass="187243" checksum="7E48BE590B33FB57" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GRS8</accession>
    <name>Q2GRS8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227253.1">
        <property type="nucleotide sequence ID" value="XM_001227252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GRS8"/>
    <dbReference type="GeneID" id="4395664"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09326"/>
    <dbReference type="HOGENOM" id="CLU_737698_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GRS8"/>
    <dbReference type="OrthoDB" id="10441030at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="375" mass="40141" checksum="F645FBADD2A59099" modified="2006-03-21" version="1">MESSTTTQSGLSFGLDAFSIDTSPPHSCVSPNSSYPSSVSPNLTYPSCVSPEINDKPQPLSENGFTKAPKAQANGNTKSQATTEQLHHQSNGGVTGIRTQWQPLQDDKNNKQHAPFEPEPLAGLKQKFPPSPSESERAKPQYPDPTNNPAQGINSAGIDLGLQSKTAWWGLLDVTKSMAATKTRLAESARFAQMSVAEVAYASAAIADLEDAVVLAQGELVLRQQVIRRLEEQVKTLVVELEERDNALAGAAADADLIKSLVAELQARERNGDAGNDAKSSAQEGGEPKAGMTRHVKWAADDNDKIVNNVIKLIQDLEYRYSLLRESLESTHTMFREALALAVPAFASHLAETAKKASDAAAQAALDAGEDNAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GS48</accession>
    <name>Q2GS48_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Endoplasmic reticulum chaperone BIP</fullName>
            <ecNumber evidence="4">3.6.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endoplasmic reticulum chaperone BiP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Immunoglobulin heavy chain-binding protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CHGG_09206</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="4"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227133.1">
        <property type="nucleotide sequence ID" value="XM_001227132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GS48"/>
    <dbReference type="FunCoup" id="Q2GS48">
        <property type="interactions" value="1124"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GS48"/>
    <dbReference type="GeneID" id="4395059"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09206"/>
    <dbReference type="eggNOG" id="KOG0100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_7_0_1"/>
    <dbReference type="InParanoid" id="Q2GS48"/>
    <dbReference type="OMA" id="VQRDIKH"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000009">
        <property type="entry name" value="DnaK-type molecular chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208553" description="Endoplasmic reticulum chaperone BIP" evidence="17">
        <location>
            <begin position="33"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="650"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAQ85192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="661" mass="72265" checksum="36EBEF56BCD73C7F" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSG3</accession>
    <name>Q2GSG3_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrodipicolinate synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227018.1">
        <property type="nucleotide sequence ID" value="XM_001227017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSG3"/>
    <dbReference type="STRING" id="306901.Q2GSG3"/>
    <dbReference type="GeneID" id="4395575"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09091"/>
    <dbReference type="eggNOG" id="ENOG502QWNS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_0_2_1"/>
    <dbReference type="InParanoid" id="Q2GSG3"/>
    <dbReference type="OMA" id="IAPKACI"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF52">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="39892" checksum="BED71B8B346D9363" modified="2006-03-21" version="1">MSPHNDAPSPSGSYTAGFNRMQYPSTVTSSLMTGHLNAMEPHSPLSSSYSTTSESSDFHMDRPLVPGVYVPTMCFFDEDTEDVDTDAIASHAVRLARAGVTGLATQGSNGEAVHLTHSERQLVTATTRKALNESGYAHMPIIVGCGSQSTRETIQLCREAWEAGGDYALVLPPSYYAPLFAPASETITSFFTAVADASPIPIVIYNFPGAVGGLDLSSDTILRLAEHPNIVGVKLTCGNTGKLNRVAAATRKLAGPAFNPAKPDFLVLAGSADFTVQSLVAGGHGILAGLANIAPKACIRTMELYGQGKLAEAQAMQEVVAQGDWTAIQGGVVGVKSGLQGWMGYGGHARSPLPRPSAEQARQWKEGFRDLVLLEKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSH6</accession>
    <name>Q2GSH6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase family 43 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_09078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001227005.1">
        <property type="nucleotide sequence ID" value="XM_001227004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSH6"/>
    <dbReference type="STRING" id="306901.Q2GSH6"/>
    <dbReference type="GeneID" id="4395142"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09078"/>
    <dbReference type="eggNOG" id="ENOG502RYYQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010779_0_1_1"/>
    <dbReference type="InParanoid" id="Q2GSH6"/>
    <dbReference type="OMA" id="YRPYEST"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08983">
        <property type="entry name" value="GH43_Bt3655-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF8">
        <property type="entry name" value="ARABINOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208973" description="Glycoside hydrolase family 43 protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="31544" checksum="E4A1D6ED95814781" modified="2006-03-21" version="1">MARIRPGALAILVALLSSWSCLVLGFAIDVPGYNSQVARRADPNLAGYLGVFFLGADPYVYFYLSNGNDPLSFRALNRGSPVIRPTKGTGGVRDPTIIPGGGSEAGKKWYIIGTDLNIGKYPTSDPRHTGSPSNIRIRYAYTNDFQTFSAPQTLIDKNPTNIIDLNFVPLNGTDSTSFLRFMKDETRKAVFVEVSENGLFGSWTRPGGDSAIIQQGVEGPAAYLDNTNPGKVHLLLDFYGDDGYRPFESTNPKSNNGWTASNRGAFPRNLRHGSVLPVGSANYQALGAKWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GSK7</accession>
    <name>Q2GSK7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</fullName>
            <ecNumber evidence="15">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CHGG_09047</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
            <orientation evidence="15">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="15"/>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ85033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226974.1">
        <property type="nucleotide sequence ID" value="XM_001226973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GSK7"/>
    <dbReference type="STRING" id="306901.Q2GSK7"/>
    <dbReference type="GeneID" id="4394724"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_09047"/>
    <dbReference type="eggNOG" id="KOG2658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014881_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GSK7"/>
    <dbReference type="OMA" id="QGDGKPH"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 15" id="KW-0288">FMN</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 15" id="KW-0520">NAD</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="15" id="KW-0813">Transport</keyword>
    <keyword evidence="17" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="16">
        <location>
            <begin position="378"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAQ85033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="495" mass="53785" checksum="966676E231228146" modified="2006-03-21" version="1">MLSRTAAPTKASARAISSAVSTAAAATTPQQCRSFATVQDAGAATVRTYGGLRDQDRIFQNLYGRYPPDLKHAKKMGDWHKTKEIILKGHDWIIGEVKASGLRGRGGAGFPSGLKWDWDKDNKPRYLVVNADEGEPGTCKDREIMRKDPHKLVEGCLVAGRAMNASAAYIYIRGEFIEEAAVLQNAINEAYADGLIGKNACNSGYDFDVYVHRGGGAYVCGEETSLIESLEGKPGKPRLKPPFPAAVGLFGCPSTVANVETVAVAPTICRRGGSWFAGFGRERNQGTKLYCISGHVNNPATVEEEMSIPLRELIDKHCGGVRGGWDNLQAVIPGGSSTPILPKSVCDDQLMDFDALKDSQSGLGTAAVIVMDKSADVVRAISRLSHFYRHESCGQCTPCREGSKWTEQIMQRFEKGLGREREIDMLQELTKQVEGHTICALGEAFAWPIQGLIRHFRPELEARMQQFAKETGGEALAGGWNHDAKLKGQLVSPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GU55</accession>
    <name>Q2GU55_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_08499</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408034">
        <property type="protein sequence ID" value="EAQ84485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001226426.1">
        <property type="nucleotide sequence ID" value="XM_001226425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GU55"/>
    <dbReference type="SMR" id="Q2GU55"/>
    <dbReference type="STRING" id="306901.Q2GU55"/>
    <dbReference type="GeneID" id="4395034"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08499"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_823867_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GU55"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="YTH" evidence="3">
        <location>
            <begin position="195"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ84485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="37960" checksum="3796516D5B43F997" modified="2006-03-21" version="1">MFGTMGYAAPEALGYFDEDDATITYTISVDIWAVGTIALTLLLGRDVFPRQGDLSRYVNQQRALDFAREEGGELSDSCRDFVTRMLAPHPVTRPTAIAALAHPWLKQAILPPPPLDDDNEIHVPQHTSQSDSASPPTAHRIKEESPLRQSPRYSPVKLELYPTRDSASIERINHFLSLDNTLLTPKLRTVLSPENRYFILRSDNATDIETSAAHDVWTSSSRVNNMLDKAYALSGGHVVMLFSVVLSRKFCGIARMTSPLDWDNTDPHWVEDVWEGRFTLEWLSLIELPFDGVKHVPVKESTPGFRAISCYDGTQISRGSAWELFRAYSAEERRQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUV8</accession>
    <name>Q2GUV8_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_08246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225902.1">
        <property type="nucleotide sequence ID" value="XM_001225901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUV8"/>
    <dbReference type="STRING" id="306901.Q2GUV8"/>
    <dbReference type="GeneID" id="4393649"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08246"/>
    <dbReference type="eggNOG" id="KOG2570">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023529_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GUV8"/>
    <dbReference type="OMA" id="MPTQRRG"/>
    <dbReference type="OrthoDB" id="10263741at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10568">
        <property type="entry name" value="SWIB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="248"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ86993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="466" mass="52150" checksum="8CD349AC5F9EFD2F" modified="2006-03-21" version="1">MQPQYRGYGQQHAPPRAGGGGQHVPQRRGGIGPMMSAGPHHSVPMTQAQINQQHHQQQQANHLAKLRSGKPTDKNLPDGVEEGLSAGSDVAACYTQLRDLERRLDATMTRKSNTVEDQFWQGNGLGVDTFDFSSNLESTYRVKIEGRLLDDEDEVEADEEQRKGDDNEAEGDKMETDSPSKTKSKPAAAAKRPRPARQGAEASVEWKKPDRTPAGAGNLPAMADFDEFTFKRNGDENMNITINLFRHEDPERFELTPALADIIDMREATRQEAVMALWEYIKLMNLQEDEEKRNFRCDDLLRKLNDYLTPHLRALPPREAGLHDPRRRGLPQGPPADHLRRARAGRRLAALRGCRPSCTTPQYAGMLKEGRRARRPARRAHPGRRLSPRPSTPFLASMARDPVGFVKGWLSSQKRDLEVIMGEATRGGGEDATGDEWRRGGRDSVWATTNARESVNVLLAKQPTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUY2</accession>
    <name>Q2GUY2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_08222</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225878.1">
        <property type="nucleotide sequence ID" value="XM_001225877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUY2"/>
    <dbReference type="STRING" id="306901.Q2GUY2"/>
    <dbReference type="GeneID" id="4394030"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08222"/>
    <dbReference type="eggNOG" id="KOG0257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034385_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GUY2"/>
    <dbReference type="OMA" id="KNWRYPG"/>
    <dbReference type="OrthoDB" id="2108at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050596">
        <property type="entry name" value="AspAT/PAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383:SF1">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="89"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ86969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="473" mass="52659" checksum="9608306B1007E283" modified="2006-03-21" version="1">MASAAEAFANRKFSINRNTGVPRPARRFSIGEPGLNEASSKIHRQFRAAHEGHLPHAGLDATRASTGVVWCTERAAEFGFLEEPDKWANLGQGAPEVEDDIEGCFARPTHIDISAASREYGPTAGIKPLREAVARLYNEMHRKGKPSQYTWENVAIVPGGRAGLIRIAAVLNNAYVGFFIPDYTAYNEMLSLFKNFAAIPVPLSEEDGYHIHPEKIAEEISRGTGVILTSNPRNPTGRVVQNPELAEIQDICRERATFVSDEFYSGYNYTSNCDGSTISAAENVIDVDEDDVLIIDGLTKRFRLPGWRVAWILGPKEFIKAIGSCGSYLDGGTNVPFQEAAVPMLEPSLVKTEMVALQTHFRHKRDYVVGRLRSMGFVIRHVPDSTFYLWLNLEGLPGPISDGLNFFQACLNEKVIVVPGIFFDLNPARRRDLFDSPCHHFVRFSYGPRMDVLKMGCDGIERVINKFKNLVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GUY8</accession>
    <name>Q2GUY8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_08216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225872.1">
        <property type="nucleotide sequence ID" value="XM_001225871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GUY8"/>
    <dbReference type="GeneID" id="4394249"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08216"/>
    <dbReference type="HOGENOM" id="CLU_2527253_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GUY8"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="84" mass="8807" checksum="25A1D06F244B061E" modified="2006-03-21" version="1">MATFVEDPRSIQQQTLSNLADHLDVCTRAGFLTVGNAAGNGGISTLKSADQSARGWLDLTGENMPPARLPEGFTTKGIVASTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV56</accession>
    <name>Q2GV56_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_08148</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225804.1">
        <property type="nucleotide sequence ID" value="XM_001225803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV56"/>
    <dbReference type="STRING" id="306901.Q2GV56"/>
    <dbReference type="GeneID" id="4393767"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08148"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1331807_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GV56"/>
    <dbReference type="OrthoDB" id="5241802at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF16">
        <property type="entry name" value="ANKYRIN-1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ86895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="206" mass="22457" checksum="A74F040A187735CC" modified="2006-03-21" version="1">MACVKVLVEFGADSDIRTSNGTTALQLCFEMGDGTEEIVHFLLGRGADPNAQVGMSRTMLHMAAAMGLVRVVPLLLSAGVDATRCDSFGQTPWDNATRYGHGEIADALAEAGGRPIISQHSLLDTYQEGYPETLEDYEHHSPAGSMEQPPYSSVMLTPGTQGGEKLLGRMKKHWSRLKKKLRYCTVRGTRGSEWDEKKKVIIGSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV60</accession>
    <name>Q2GV60_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">O-methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CHGG_08144</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin-dependent halogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225800.1">
        <property type="nucleotide sequence ID" value="XM_001225799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV60"/>
    <dbReference type="GeneID" id="4394158"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08144"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_305659_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GV60"/>
    <dbReference type="OMA" id="YEKWDAH"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050816">
        <property type="entry name" value="Flavin-dep_Halogenase_NPB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747">
        <property type="entry name" value="FAD-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAD-binding" evidence="10">
        <location>
            <begin position="7"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="9">
        <location>
            <begin position="852"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="558"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="564"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAQ86891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1013" mass="108613" checksum="521AACA7D0E4662D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV67</accession>
    <name>Q2GV67_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_08137</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225793.1">
        <property type="nucleotide sequence ID" value="XM_001225792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GV67"/>
    <dbReference type="GeneID" id="4394139"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08137"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_20_3_1"/>
    <dbReference type="InParanoid" id="Q2GV67"/>
    <dbReference type="OMA" id="KWINDGS"/>
    <dbReference type="OrthoDB" id="5396311at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="48"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="383"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ86884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="411" mass="46310" checksum="42EB9A47613A4D54" modified="2006-03-21" version="1">MAPEDNIQQAIQAVRDGQSIRKASEAWGVPFSTLRDRVVANAQPKGQYEAQVMQKLSPDQEKHLADWVLAQKALGLPVKHRQIEVFANRILRASGSDQTVGKHWLQKFIRRYPVLKTKKDRRMDIKRLDGASTDVIKAWFHFLAIPVIQTIDPQDRWNMDETGIMEGLGTNGLCVGSSETKEALSKHPESRIWTTIIECISATGKALPPLVIFKGKDIQQQWFPDNGKDLDPLRNWRFSTSQNGWTSNDIALEWLTKIFCPTTATSKKRLLIVDGHGSHETDDFMWTCFSNNIYLFLPGHASHVLQPLDLSVFSPLKTTYRRGINDLTVMTDCVPIGKRLFLRRYAQARKDAIKERNIRSGWKASGLWPVNLDKPLMSRLLLNPTNQPVSQPASQSAGQSAIQPASQPVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GV72</accession>
    <name>Q2GV72_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CHGG_08132</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225788.1">
        <property type="nucleotide sequence ID" value="XM_001225787.1"/>
    </dbReference>
    <dbReference type="GeneID" id="4394003"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_08132"/>
    <dbReference type="eggNOG" id="KOG0502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_2_1"/>
    <dbReference type="InParanoid" id="Q2GV72"/>
    <dbReference type="OMA" id="NIQSKYY"/>
    <dbReference type="OrthoDB" id="4583255at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="5">
        <location>
            <begin position="405"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="837"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="907"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="937"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="970"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1006"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1039"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1072"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1218"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1357"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1220"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1357"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1388"/>
            <end position="1402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAQ86879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1402" mass="154840" checksum="8A22D5BF8CBD7F90" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWD6</accession>
    <name>Q2GWD6_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225374.1">
        <property type="nucleotide sequence ID" value="XM_001225373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWD6"/>
    <dbReference type="GeneID" id="4393377"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07718"/>
    <dbReference type="HOGENOM" id="CLU_2605820_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GWD6"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="79" mass="8461" checksum="8361AC243EDE81CC" modified="2006-03-21" version="1">MKNGVEESQPVSRSRSGLYPPKLGVASLPTYMPMVGIDGRIQVERAPMNYTQGVSSAHASPYASAPPDAMRKPSAPPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GWF0</accession>
    <name>Q2GWF0_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CHGG_07704</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225360.1">
        <property type="nucleotide sequence ID" value="XM_001225359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GWF0"/>
    <dbReference type="FunCoup" id="Q2GWF0">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="306901.Q2GWF0"/>
    <dbReference type="GeneID" id="4393305"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07704"/>
    <dbReference type="eggNOG" id="KOG4709">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067149_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GWF0"/>
    <dbReference type="OMA" id="EWDGFPD"/>
    <dbReference type="OrthoDB" id="551633at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019186">
        <property type="entry name" value="Nucleolar_protein_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09805">
        <property type="entry name" value="Nop25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="42"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAQ86451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="24977" checksum="0F157D531922A03E" modified="2006-03-21" version="1">MFAQPRVRKTAPAPPKKRKTTHAIEEITFDKDARSEYLTGFHKRKQARIKHAQEVAEQKAREERIEVRKQIREERKQAVEDHVQAINKILREAEHAGTGDQDQNDSEGEWGGLSDTDIPEAPIDMEEEYIDEDKYTTVTVEAVSVDRDGLHKPELEKPSEDAGPKQEGASAEEDSKKDAKRPKYPAKKNKKFRYENKFERAVEARKQRSKRRKDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX14</accession>
    <name>Q2GX14_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225146.1">
        <property type="nucleotide sequence ID" value="XM_001225145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX14"/>
    <dbReference type="GeneID" id="4394577"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07490"/>
    <dbReference type="eggNOG" id="ENOG502RAPJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178665_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GX14"/>
    <dbReference type="OMA" id="TERNCKF"/>
    <dbReference type="OrthoDB" id="5361929at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004208540" evidence="1">
        <location>
            <begin position="17"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="101" mass="11242" checksum="893D193A2C4C2190" modified="2006-03-21" version="1">MKASSIFLVALPLVSAWKLELWATGGRHVTMSGTRDSGCKDISFTPVLNVNKAKLNPSTSLYPDPKTFELYVNKGCRGLSYRNGKGTHKMSARKIRSYKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX33</accession>
    <name>Q2GX33_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225127.1">
        <property type="nucleotide sequence ID" value="XM_001225126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX33"/>
    <dbReference type="GeneID" id="4393390"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07471"/>
    <dbReference type="eggNOG" id="ENOG502RJDV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2440645_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GX33"/>
    <dbReference type="OMA" id="KMGCVAW"/>
    <dbReference type="OrthoDB" id="5234213at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ86218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="90" mass="9155" checksum="3E9E5F4AAE93FC48" modified="2006-03-21" version="1">MPHKPLRQLAAEKARGNKPANPSQLGDPIDLKAETSDGEDPVESPSAGGGDNIGRTGLDIPRASLEGGPDGGSGGLRVPKMGCVAWRLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GX46</accession>
    <name>Q2GX46_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aflatoxin biosynthesis ketoreductase nor-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_07458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225114.1">
        <property type="nucleotide sequence ID" value="XM_001225113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GX46"/>
    <dbReference type="GeneID" id="4393574"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07458"/>
    <dbReference type="eggNOG" id="KOG1611">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_1_1"/>
    <dbReference type="InParanoid" id="Q2GX46"/>
    <dbReference type="OMA" id="CDGMMEV"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ86205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="26781" checksum="0239C11824571736" modified="2006-03-21" version="1">MPPLIVLITGGNRGLGQGLVKLFLAQPNYTVIAAVRDPNHTTAQALADLPQGAGSTLITVRYDAGSEQSATDAVSELQTKHNIDHLDIVVANAGISKQWPLVKDVKRADIQEHVEVNVLGVVSLYQATRELLQRSTVGPRFAAIGSMAGSLREQPPVPSGSYGPSKAMLNWYGIRINAEEEWLTAFILDPGWVQTEMGNRAAQVWGVAEAAPDNINDSTEGMFKVLTTAKRETHGGKLVVYTGEIKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXA2</accession>
    <name>Q2GXA2_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_07402</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225058.1">
        <property type="nucleotide sequence ID" value="XM_001225057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXA2"/>
    <dbReference type="GeneID" id="4394339"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07402"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_8_2_1"/>
    <dbReference type="InParanoid" id="Q2GXA2"/>
    <dbReference type="OMA" id="ADFLVWI"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="3">
        <location>
            <begin position="32"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ86149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="305" mass="31794" checksum="69A490C01999435D" modified="2006-03-21" version="1">MAAPQPSYTKVTHSATYPAINPTLPSLSSTGKVVVITGATGGIGRAAALSFAASGPKALVLLGRRKDALAETVLLVRTSHDSLTVESHAVDLVDSGKLRQVFADVAAAHGAIDVVIHAAGVLAPVVPLVDADPATFLDGYKTTVVGTLSLAQALVLGNGKGKEATLVNLTTAGIFFPPFPGMGAYVSSKMAAVKLLQAFGAENPHVRIHHVHPGFLDTAMSAQLSKTTKLPFSFDDISLPADFLVWVVSSEAKFLNGKVVFAAWDVDELKSREKEIVGTSPLTGELWVSYSGFPRYVGGHALGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXA7</accession>
    <name>Q2GXA7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_07397</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225053.1">
        <property type="nucleotide sequence ID" value="XM_001225052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXA7"/>
    <dbReference type="GeneID" id="4394224"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07397"/>
    <dbReference type="eggNOG" id="ENOG502QQPD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031812_1_2_1"/>
    <dbReference type="InParanoid" id="Q2GXA7"/>
    <dbReference type="OMA" id="HRSCAKT"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="180"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ86144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="407" mass="43513" checksum="D76B549F102AB334" modified="2006-03-21" version="1">MTDLTSVINDEIKRRNAEISSINEQIHANPELAYEEYKAHDAFVSVLQALGFEVTPHAFGLETAFSAEYGSGGRLVIYNAEYDALPGIGHACGHNLIASSSFAAFLGAAAALKTSNQPGRVRLLGTPAEEGGGGKLKMIANGAFAGAAACLMVHPGPGHNLPGATRGVAFVRMLANIKTRVHYTGRESHAAIAPWDGVNALDAVCLSYNAISMLRQQIRPYERVHGVFRAAGDRPNVTPADCTVEYYCRSATKRGAEALWARLEKCFEGAATATGCEMRLEPLNSYADVRPSKPLCEAYIEVMPEGTVTMDEPADILAGSTDMGDVCYECPGFHGVFGIDTKEGEANHTKGFAAAAGTPESFERALECGRGMAAVGWRVLSDDAFAEKVKREWEEDMQRAAEGKVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXC7</accession>
    <name>Q2GXC7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CHGG_07377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ86124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001225033.1">
        <property type="nucleotide sequence ID" value="XM_001225032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GXC7"/>
    <dbReference type="STRING" id="306901.Q2GXC7"/>
    <dbReference type="GeneID" id="4393631"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07377"/>
    <dbReference type="eggNOG" id="ENOG502R9AJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041041_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GXC7"/>
    <dbReference type="OMA" id="HNDMGCD"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF54">
        <property type="entry name" value="FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="59"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAQ86124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
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    </evidence>
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</entry>
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                <person name="Untereiner W.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="1947" mass="212006" checksum="A5342BB30E6F8180" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
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                <person name="Untereiner W.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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</entry>
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            <end position="218"/>
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        <location>
            <begin position="467"/>
            <end position="483"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ85965.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="911" mass="102498" checksum="C416FA30349C847B" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
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            <taxon>Sordariomycetidae</taxon>
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            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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    </feature>
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        <location>
            <begin position="123"/>
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        <location>
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    </feature>
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        <location>
            <begin position="384"/>
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        <location>
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        </location>
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    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAQ85920.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1357" mass="147966" checksum="636B348B74B9D391" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GXZ4</accession>
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        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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        </lineage>
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    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
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                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
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        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:protein urmylation"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
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        <property type="project" value="EnsemblFungi"/>
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    </dbReference>
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        <property type="entry name" value="Elp2"/>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
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        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
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        <property type="entry name" value="WD40 repeat-like"/>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="48"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="206"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="356"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="589"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="479"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="499"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAQ85907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="794" mass="85836" checksum="1D7F35EB79C59172" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GY38</accession>
    <name>Q2GY38_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CHGG_07116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224772.1">
        <property type="nucleotide sequence ID" value="XM_001224771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GY38"/>
    <dbReference type="GeneID" id="4393131"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07116"/>
    <dbReference type="HOGENOM" id="CLU_2359514_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GY38"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAQ85863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="96" mass="10622" checksum="66148A8F45BB3E1A" modified="2006-03-21" version="1">MHQPPQQPGRRGFDCALVCEMERANDGEDAPHENRWKEKADAVGLVVGIWNRLEEDIEVAKPMVEIVVNGHGISGLVDVGSSDHVDNSVVKHVEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYC8</accession>
    <name>Q2GYC8_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_07026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224682.1">
        <property type="nucleotide sequence ID" value="XM_001224681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYC8"/>
    <dbReference type="STRING" id="306901.Q2GYC8"/>
    <dbReference type="GeneID" id="4393858"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_07026"/>
    <dbReference type="eggNOG" id="ENOG502RX84">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088128_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GYC8"/>
    <dbReference type="OMA" id="WPTYKES"/>
    <dbReference type="OrthoDB" id="10264870at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070461">
        <property type="term" value="C:SAGA-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024738">
        <property type="entry name" value="Hfi1/Tada1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12767">
        <property type="entry name" value="SAGA-Tad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="229" mass="24973" checksum="78EF1F36FE35CAE1" modified="2006-03-21" version="1">MVDINPAALSRPSISLSTPVLSKQSINVSVPSIHKAPKTSQLIPARIDLEPIYTALKASIGTEQWPTYKESITNFLIGTALPSSAHAEFSERIEPILASPDGSKEHLHNQLIAAIYGNVTREMPDQGLAPWVSTNDKPSPATGSKPVSGDAAERRLKGEVMQLPARDRRRIKDLAHNDVSQGMRWSIAESMLTACLSLIRTSRSRICSRTRPGCDPPRRPRCLPVRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYH9</accession>
    <name>Q2GYH9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_06975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408033">
        <property type="protein sequence ID" value="EAQ85722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224631.1">
        <property type="nucleotide sequence ID" value="XM_001224630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYH9"/>
    <dbReference type="STRING" id="306901.Q2GYH9"/>
    <dbReference type="GeneID" id="4393244"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_06975"/>
    <dbReference type="eggNOG" id="ENOG502S76B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049918_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GYH9"/>
    <dbReference type="OMA" id="YMTGVRN"/>
    <dbReference type="OrthoDB" id="10260017at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ85722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="327" mass="36347" checksum="EEE21870D9BBD9C2" modified="2006-03-21" version="1">MTTLTMDSAYTPSQVDAYLTHIGLPPSFHPSANPTLNLTYLTTLFTHQITTIPYDNLSIHYSPTHTIDLNPQALFTKMITANRGRGGYCMENSILFNHMLRALGFSDAYLAGVRIRPRVAGVPQGEAYTGWVHLVNIVSVPGEAAKYVLDVGFGGDGMTRPMPLVEGAVQHNGIGTQEVRLGRRFIPNQRFRGEGAERMWVYEVRNGVERDWVPFFAFHDRFEFTEADFGNINWYTSQAKESHQTWTTLAIRFLRGVAEDGTAKVVGKVMMAEGVIKENLTGKTRLVKVCKTEEERVAALAELFGIHLTPEEAASIKGRPAELLGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GYZ7</accession>
    <name>Q2GYZ7_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="12">3-ketoacyl-coA thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CHGG_05249</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224463.1">
        <property type="nucleotide sequence ID" value="XM_001224462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GYZ7"/>
    <dbReference type="STRING" id="306901.Q2GYZ7"/>
    <dbReference type="GeneID" id="4392771"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05249"/>
    <dbReference type="eggNOG" id="KOG1389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_1_1_1"/>
    <dbReference type="InParanoid" id="Q2GYZ7"/>
    <dbReference type="OMA" id="RWCASSM"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF10">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="10">
        <location>
            <begin position="30"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="11">
        <location>
            <begin position="293"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="8">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAQ88630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="415" mass="43875" checksum="2F6FD9B14BB1B86F" modified="2006-03-21" version="1">MAVERLGSILKHLSPSSSLSHITSKNADDIVITLALRTPLTKARKGGLKDSSLEYISFALLDEVRKRSNIDPALVEDICLGNVSDGKAAYKLRASALAAGFPNTTSCSSLNRFCSSGLKAVADVAHAISSGSIEVGIAIGVEQMTIGGDALEKPFDEKVTSRSQEAADCMQPMGWTSENVSRDFGITREEMDKYAAESFRRAEQAQKDGLFDDEIVPIKTTVQGPDGEWKEITVSKDDGIRPGTTAESLSKIRVAFPQWGPTTTGGNASQVTDGAAAVLLMKRSMAIKLGQPIMAKYVGSTVAGLAPRIMGIGPTVAIPKLLAQHGITLADIDVVEVNEAFASMAVYCRDTLGLDWAKMNPRGGAIALGHPLGATGARQIVTGLSECRKNGKKLLLTSMCIGTGMGMAGLFVNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZA1</accession>
    <name>Q2GZA1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose receptor Git3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224359.1">
        <property type="nucleotide sequence ID" value="XM_001224358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZA1"/>
    <dbReference type="STRING" id="306901.Q2GZA1"/>
    <dbReference type="GeneID" id="4392220"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05145"/>
    <dbReference type="HOGENOM" id="CLU_024810_2_0_1"/>
    <dbReference type="InParanoid" id="Q2GZA1"/>
    <dbReference type="OrthoDB" id="4575619at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="40884" checksum="0052C2870F8ED086" modified="2006-03-21" version="1">MSKSTLSARCWGWAYCFVCYGGPLALALSHLHVKMPKDVRLHSDVEGWCWGFPGQDMLQIYIPVWGSIGASLIIYLGAVGRILRNTHHNKKEWQSFLSTRCSTSSTLPTARNTVPWRDSVLSLSDWPLSPSSGGVLFGTQCAEAKASGRPRPVTYPSPAYRPSVSATDTWLHSAFAACPRPAPTPPPSKGLFVRNMSWHAKVGDQYLWTGLMLAGSLLVTWLPGTIGLGWKLTHPELPAPLGFRATVAIMLPLQGLWVSGIFLTLNWKDIRQGTIRPPSRTAISGLLEEPLLRLRGTSVSSRGTDHEVEKVKKDLKVTIPWNRQTKSDDWDFVDIGIPSRANTVTRPRPNSEPVISPLLPSPVIRRNGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZE7</accession>
    <name>Q2GZE7_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224313.1">
        <property type="nucleotide sequence ID" value="XM_001224312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZE7"/>
    <dbReference type="GeneID" id="4391615"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05099"/>
    <dbReference type="eggNOG" id="ENOG502ST0G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_513861_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZE7"/>
    <dbReference type="OrthoDB" id="5334244at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="56535" checksum="29EA710F0F6730C5" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZJ1</accession>
    <name>Q2GZJ1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CHGG_05055</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224269.1">
        <property type="nucleotide sequence ID" value="XM_001224268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZJ1"/>
    <dbReference type="STRING" id="306901.Q2GZJ1"/>
    <dbReference type="GeneID" id="4392906"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05055"/>
    <dbReference type="eggNOG" id="ENOG502QPIC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024204_1_0_1"/>
    <dbReference type="InParanoid" id="Q2GZJ1"/>
    <dbReference type="OMA" id="TFWAWNL"/>
    <dbReference type="OrthoDB" id="434240at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAQ88436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="443" mass="47095" checksum="3244AC4FF9459D20" modified="2006-03-21" version="1">MTFKFSDLLLVRVVAGPLCDKFGPRKVFGGLLLVGSIPLGLAPLVHSAEGLYASRFFIGILGGAFVPCQVWTTGFFDNNIVGTANALTGGFGTAGGGITYFIMPAVFNSFVARGFSKGQAWRLTFIVPLSMVIVVGVALLCLCPDTPAGPWGERHHTLSEDHGPHGDSSVAATVTNIPGSITDRFPSDTPENLSAEESDDKKKKETYISAPVIFDQEAQILSQGNLEAAHGEIIAKSTLWDVTFSPQTVFHVCSYMNSFGAELAINAILASYYFKTFPYFSQTDATNRAAIFGFLDFVTRPFGGAVSDLLYKHSGHNLWVKKGWIVGCGIIAGTLLIIFGQLSPHDESTVFALISLVAIFLQAGSGANFSLLPHVHPSANGILSGLTGAGGNLGGVIFSVVFRSMGDGTNYAKGFWVIGVIHVGLTLALSWIPPLPRGQRGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q2GZL1</accession>
    <name>Q2GZL1_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7053 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_05035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224249.1">
        <property type="nucleotide sequence ID" value="XM_001224248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2GZL1"/>
    <dbReference type="STRING" id="306901.Q2GZL1"/>
    <dbReference type="GeneID" id="4391820"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_05035"/>
    <dbReference type="eggNOG" id="ENOG502RW2C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090750_0_0_1"/>
    <dbReference type="InParanoid" id="Q2GZL1"/>
    <dbReference type="OMA" id="DTYWYPP"/>
    <dbReference type="OrthoDB" id="4276610at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055481">
        <property type="entry name" value="DUF7053"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117:SF1">
        <property type="entry name" value="DUF3074 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23155">
        <property type="entry name" value="DUF7053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7053" evidence="1">
        <location>
            <begin position="9"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="190" mass="20822" checksum="CE540F8A631215A8" modified="2006-03-21" version="1">MSPPEPFIVITRVPIPASLPPAAVLASLQTYEALIKPNPYLDRYERRPVEPDEVANDPFFPKDGQELQAYVVYDRVPIIPGVGSWATKEVAIPCAFQRFEHGVRCCAHAQGGVTVRSSYEVRRRGEVTDGPGLVVGPDSGDYELVDISSIECGALVKPFVKMRFSSAHQELLEQVVKNLMQPSGEQSGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H076</accession>
    <name>Q2H076_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CHGG_04820</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2005-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Giovannoni S.J."/>
                <person name="Cho J.-C."/>
                <person name="Ferriera S."/>
                <person name="Johnson J."/>
                <person name="Kravitz S."/>
                <person name="Halpern A."/>
                <person name="Remington K."/>
                <person name="Beeson K."/>
                <person name="Tran B."/>
                <person name="Rogers Y.-H."/>
                <person name="Friedman R."/>
                <person name="Venter J.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 148.51</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2006-02" db="EMBL/GenBank/DDBJ databases">
            <title>Annotation of the Chaetomium globosum CBS 148.51 Genome.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Birren B."/>
                <person name="Lander E."/>
                <person name="Galagan J."/>
                <person name="Devon K."/>
                <person name="Nusbaum C."/>
                <person name="Ma L.-J."/>
                <person name="Jaffe D."/>
                <person name="Butler J."/>
                <person name="Alvarez P."/>
                <person name="Gnerre S."/>
                <person name="Grabherr M."/>
                <person name="Kleber M."/>
                <person name="Mauceli E."/>
                <person name="Brockman W."/>
                <person name="Rounsley S."/>
                <person name="Young S."/>
                <person name="LaButti K."/>
                <person name="Pushparaj V."/>
                <person name="DeCaprio D."/>
                <person name="Crawford M."/>
                <person name="Koehrsen M."/>
                <person name="Engels R."/>
                <person name="Montgomery P."/>
                <person name="Pearson M."/>
                <person name="Howarth C."/>
                <person name="Kodira C."/>
                <person name="Yandava C."/>
                <person name="Zeng Q."/>
                <person name="Alvarado L."/>
                <person name="Oleary S."/>
                <person name="Untereiner W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 148.51</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001224034.1">
        <property type="nucleotide sequence ID" value="XM_001224033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H076"/>
    <dbReference type="STRING" id="306901.Q2H076"/>
    <dbReference type="GeneID" id="4392668"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04820"/>
    <dbReference type="eggNOG" id="ENOG502S0VZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006331_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H076"/>
    <dbReference type="OMA" id="DYCFHVG"/>
    <dbReference type="OrthoDB" id="775571at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF70">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="200"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="606"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="835"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAQ88201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="1014" mass="112044" checksum="F39A70FDB1C1841D" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0J6</accession>
    <name>Q2H0J6_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CHGG_04700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223914.1">
        <property type="nucleotide sequence ID" value="XM_001223913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0J6"/>
    <dbReference type="STRING" id="306901.Q2H0J6"/>
    <dbReference type="GeneID" id="4392208"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04700"/>
    <dbReference type="eggNOG" id="KOG2362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028286_7_0_1"/>
    <dbReference type="InParanoid" id="Q2H0J6"/>
    <dbReference type="OMA" id="VYTACRT"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF23">
        <property type="entry name" value="MOSC DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G05900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="MOSC" evidence="3">
        <location>
            <begin position="342"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAQ88081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="507" mass="56024" checksum="D16928CCADBBC9D5" modified="2006-03-21" version="1">MGKIQGSVPGSEAGCVKSACHSRLVTTHKHNRGRSRTNTGRVKSSMDGSTVPPRGPAIDASSAFILLITIFAFFLPILLYFPPVPPSKRDALLETHTQVGLSPSESGLKGHHSKANNSNGSDNNPTSKIRSLFIYPLKSCRGIEVRQSKVLPTGLEFDRLYTFAQLKSPFPLALPSPSQDQDQDKSTEKEKEAHTWHFITQRQFPLLATIRVDLFTPDPLKTRVVGTTPPPPPPSASASASASAPFLLVRFPWRERGLRGLLGWVGAKLARGWRAQPEREFVLPVAYPTAEEIAARGYGEGEEVVVWRETVRALDMGVEVPEELALYLGVSNRLGLFRVDPGRLREVFRCAPRRGEAGYQPVTGFQDAYPLHLLNLTSVRDFEAKIEKDEALRELDPRRFRANIIVDGDDSPYDEETWKRIRFRPGPSSKRDASEFHVSCRTVRCKLPNVDQDTGSRHPMQPDRALRKFREVDEDLGRAGAGAEGVLLVPTAVEVAAAGGAIVWVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2023-06-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0K9</accession>
    <name>Q2H0K9_CHAGB</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CHGG_04687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223901.1">
        <property type="nucleotide sequence ID" value="XM_001223900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0K9"/>
    <dbReference type="GeneID" id="4392254"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04687"/>
    <dbReference type="HOGENOM" id="CLU_2830990_0_0_1"/>
    <dbReference type="InParanoid" id="Q2H0K9"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAQ88068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001056"/>
        </source>
    </evidence>
    <sequence length="66" mass="7318" checksum="E597A7BA0F3124E9" modified="2006-03-21" version="1">MFGSPTHLSFAHVRSDHLDCAGADAHRHESASVGQGKVARKRKSNTSRFRRIVVRWLGIPNGPAPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q2H0P4</accession>
    <name>Q2H0P4_CHAGB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lon protease homolog</fullName>
            <ecNumber evidence="8">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CHGG_04652</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)</name>
        <name type="common">Soil fungus</name>
        <dbReference type="NCBI Taxonomy" id="306901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0002115" last="E0002115">
            <title>Draft genome sequence of the cellulolytic fungus Chaetomium globosum.</title>
            <authorList>
                <person name="Cuomo C.A."/>
                <person name="Untereiner W.A."/>
                <person name="Ma L.-J."/>
                <person name="Grabherr M."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="25720678"/>
            <dbReference type="DOI" id="10.1128/genomeA.00021-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8 11">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="8"/>
    <dbReference type="EMBL" id="CH408032">
        <property type="protein sequence ID" value="EAQ88033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001223866.1">
        <property type="nucleotide sequence ID" value="XM_001223865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2H0P4"/>
    <dbReference type="STRING" id="306901.Q2H0P4"/>
    <dbReference type="GeneID" id="4392121"/>
    <dbReference type="VEuPathDB" id="FungiDB:CHGG_04652"/>
    <dbReference type="eggNOG" id="KOG2004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004109_4_0_1"/>
    <dbReference type="InParanoid" id="Q2H0P4"/>
    <dbReference type="OMA" id="MPMNQEY"/>
    <dbReference type="OrthoDB" id="2411602at2759"/>
    <dbReference type="Proteomes" id="UP000001056">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000091">
        <property type="entry name" value="Lon protease homolog 2, peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000039">
        <property type="entry name" value="Lon protease homolog 2, peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="ATP DEPENDENT LON PROTEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </db